A Research Protocol to Evaluate the Efficacy of Powerball versus Mulligan Mobilization with Movement on Pain and Function in Patients with Lateral ...

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Journal of Pharmaceutical Research International

                            33(45B): 491-500, 2021; Article no.JPRI.74474
                            ISSN: 2456-9119
                            (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919,
                            NLM ID: 101631759)

            A Research Protocol to Evaluate the Efficacy of
               Powerball versus Mulligan Mobilization with
               Movement on Pain and Function in Patients
                                 with Lateral Epicondylitis
                                              Shivani Uttamchandani1 and Pratik Phansopkar1*
                 1Department     of Musculoskeletal Physiotherapy, Ravi Nair Physiotherapy College, Datta
                                     Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, India.

                                                                                             Authors’ contributions

                This work was carried out in collaboration between both authors. The study's design was
        recommended by author SU. The study was created and designed by authors SU and PP. This
 article's draft was written by author SU. The final text was examined and authorized for publication by
                               authors SU and PP. Both authors read and approved the final manuscript.

                                                                                                  Article Information

                                                                                   DOI: 10.9734/JPRI/2021/v33i45B32831
                                                                                                                  Editor(s):
                                               (1) Dr. Francisco Cruz-Sosa, Metropolitan Autonomous University, México.
                                                                                                                Reviewers:
                                                                     (1) Yenew Alemu Mihret, Injibara University, Ethiopia.
                                                            (2) Sabah Abdellatif Hussein Ali Beza, Cairo University, Egypt.
                                            Complete Peer review History: https://www.sdiarticle4.com/review-history/74474

                                                                                           Received 28 July 2021
  Study Protocol                                                                       Accepted 04 October 2021
                                                                                       Published 09 October 2021

ABSTRACT

 Background: Amongst the most frequently repeated stress conditions within the elbow joint
 includes lateral epicondylitis (LE). The extensor carpi radialis brevis muscle attachment is affected
 mostly. The management of an individual with LE that manifests itself in repetitive upper extremity
 motions is the purpose of this research. There seems to be no study on the effects of PowerBall
 device training on the pain and function in individuals with Lateral Epicondylitis. “PowerBall device”
 practice is a type of strength training.
 Methods / Design: After conducting initial evaluations and allocation, the subjects (n=50) with LE
 will be involved in a randomized controlled study and classified either in an intervention group or a
 conventional group. The interventional group will do “PowerBall device” exercises, while others in
 the control group, doing MMWM. These groups will receive basic movements and ultrasound in
 accordance with the procedures.
_____________________________________________________________________________________________________

*Corresponding author: E-mail: drpratik77@gmail.com;
Uttamchandani and Phansopkar; JPRI, 33(45B): 491-500, 2021; Article no.JPRI.74474

 Discussion: The PRTEE scale measured the intervention's impact on pain and function in patients
 with LE, and a Hand-held Dynamometer was utilized to quantify grip strength. The findings will give
 considerable support for the use of the "PowerBall device" exercise and MMWM on LE patients.
 Conclusion: Conclusion will be drawn post study so as to see whether PowerBall device is more
 helpful or Mulligan Mobilization with Movement on pain and function in patients with LE. This study
 will give better approach to the therapist in managing the condition.

Keywords: “PowerBall device”; MMWM; LE; extensor carpi radialis brevis muscle; pain & function;
          grip strength.

ABBREVIATIONS                                           Frequent upper - limb activities, such as
                                                        computer use, dominant forearm pronation and
MMWM :     Mulligan mobilization with movement          supination, lifting heavy, and repeated vibration,
LE     :   Lateral Epicondylitis                        are perhaps the most common causes in men
PRTEE:     Patient Rated Tennis Elbow Evaluation        and women [7]. Since this upper limb relies on
RCT :      Randomised Control Trial                     peripheral muscles, ligaments, and capsules to
QOL :      Quality Of Life                              direct action, it is frequently seen [8]. Despite its
AVBRH:     Acharya Vinobha Bhave Rural Hospital         name, commonly found in sports such as
OPD :      Out-patient Department                       badminton, swimming, squash, baseball, and
IPD  :     In-patient Department                        throwing activities.

1. INTRODUCTION                                         Although the typical presentation of LE are
                                                        obvious and simple to identify, no optimum
Amongst the most common arm lesions is                  treatment has yet been discovered. According to
Lateral Epicondylitis (LE), also known as Lateral       evidence, corticosteroid injections are associated
Elbow Tendinopathy (LET) or Tennis Elbow [1].           with lower results in the intermediate and long-
Morris was the only one to coin the term "lawn          term compared to controls [9]. Several more
tennis arm" in 1882 [2]. The word tendinopathy          practitioners recommend for a conservative
refers to a collection of pathologies, comprising       approach as the possible treatment for LE.
recurrent overuse tendon conditions. This               Physiotherapy is a conservative treatment option
condition can affect the extensor tendons mostly        for those who have LE. The exercise regimen for
on lateral side of the forearm which is most            LE is the most common physical therapy
common in middle-aged people, with a highest            rehabilitation. In general, an exercise program
incidence of 40 to 60 years [3].                        consists of exercises conducted in a therapy
                                                        room as well as activities completed at home
It's usually a job or sports-related ailment            [10].
characterized by extended, consistent, repetitive
eccentric contractions and wrist grasping. In the       There is a higher frequency among individuals
normal community, a reported incidence of 1-3           engaged in high-risk sectors involving loading,
percent is found, with the dominant arm being           frequent gripping, and/or wrist extension
the most commonly afflicted [4]. Whereas the            activities, as well as racquet sports participants
name "tennis elbow" is misleading as tennis             [11]. Extreme loading hastens the transition from
players account for just 5 to 10% of cases, racket      healthy tendons to degenerative tendinosis,
sports involvement raises the risk of this issue        irrespective of individual risk factors including
and therefore can trigger it in 40 to 50% of            age, occupation, hobbies, or previous injury [12].
athletes [5].
                                                        In addition, the impact of resistance training on
Both men and women have similar rates of                increasing shoulder and elbow muscular strength
incidence. Approximately 75% of the people is           is being investigated, although eccentric
afflicted in their dominant arms, according to          exercises have previously demonstrated some
studies. Diagnostically and therapeutically, the        relief in the symptoms of tennis elbow [13].
extensor carpi radialis brevis muscle with              Recent research has discovered that vibrating
episodic participation of the extensor digitorum        instruments (PowerBall device) had a greater
communis, extensor carpi radialis longus, and           influence on muscular strength, pain, ROM, and
extensor carpi ulnaris muscles is perhaps the           health quality in patients with tennis elbow
most commonly pulled in muscle [6].                     injuries than dumbbell exercise [14]. Throughout

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the chronic stage, using a "PowerBall device" to             2. Between the ages of 20 and 50
impart extrinsic and intrinsic strain to the wrist,          3. Pain present on elbow’s lateral side
elbow, and shoulder muscles is believed                      4. Tenderness persists on palpation over
beneficial resistance training [6].                             the forearm extensor carpi radialis
                                                                tendon.
According to research, using the "PowerBall                  5. Diagnosis confirmed on the basis of
gadget" resulted in enhanced power. Despite the                 physical test (Cozens Test, Mill’s Test,
fact that using a dynamic PowerBall has been                    Maudsley’s Test)
demonstrated to enhance strength, function,
range of motion, tennis elbow discomfort, and           2.3.2 Exclusion criteria are as follows:
quality of life in overhead sportsmen, the majority
of frequent concerns have yet to be validated                1. Fractures present around elbow
[15].                                                        2. Any old surgical history around elbow
Mulligan Mobilisation with movement (MMWM) is                3. Any previous pathology of bone around
a kind of manual treatment that integrates                      elbow.
continuous lateral glide with physiological elbow            4. Absence of clinical signs of tennis elbow.
mobility [16]. MMWM concentrates on mobilizing               5. Any underlying deformities (Increased
the joint during physiological movements, as                    carrying angle/ hyperextended elbow)
compared       to    conventional      mobilisation          6. Steroid injection taken recently for LE
approaches that concentrate on mobilisation in a                within 3 months.
static posture. According to studies, MMWM is                7. Any history of acute trauma
effective in reducing pain and improving the                 8. Having neurological involvement.
functional capacity of elbow joints in LE patients           9. Any other systemic illness like metabolic,
[17].                                                           metastatic, infective disorders.

1.1 Aim                                                 2.4 Recruitment
The purpose of this research is to see how the
PowerBall Device, when compared to Mulligan             The orthopaedician working under AVBRH
Mobilisation with Movement, affects pain and            (DMIMSU) are invited to refer the prospective
function in patients with Lateral Epicondylitis.        patients to our in-patient department (IPD).
                                                        Patients having Lateral Epicondylitis that are
2. METHODOLOGY                                          currently undergoing physiotherapy in the IPD
                                                        will be carefully screened for research criteria.
2.1 Study Setting                                       Once the study's eligibility requirements are
                                                        fulfilled, the participants are randomly assigned
Trial will be carried out in Ravi Nair                  to one of two groups. Approval from patients will
Physiotherapy College, Musculoskeletal OPD,             indeed be accumulated before the allocation and
AVBRH Sawangi, Meghe, Wardha.                           after elaborating the purpose, nature, procedure,
2.2 Study Design and Sample Size                        prospective benefits and aftereffects of the
                                                        intervention.
The study design for patients who have been
diagnosed with Lateral Epicondylitis is a single-       2.5 Procedure
blinded RCT method. The total number of
subjects in this experimental study is 50 (n=50).       2.5.1 Participant Timeline
For three weeks, the participants would be
randomly assigned to one of the two groups: an          Study duration is of 1 year and intervention
experimental group (Group A) and a                      duration is of 3 weeks so participants will be
conventional group (Group B). Goals and                 enrolled and three weeks of intervention will be
methods of the study will be informed to the            completed successfully. Assessment will be done
Participants before being accepted, and written         on 1st day of the visit and on the 21st day i.e.
patient consent form will be signed by them.            completion or at the end of the intervention.
2.3 Participants                                        2.5.2 Implementation
2.3.1 Inclusion criteria are as follows:
                                                        Randomization will be supervised by the
    1. All subjects having symptoms for more            research coordinator and principal investigators.
       than 2 weeks                                     Participants will be asked to hand-pick a sealed

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group allocation for the recruitment into either        or her shoulder and the forearm of the sufferer,
group from the envelope.                                near to the elbow joint. While doing prolonged
                                                        lateral glides with the belt, the participants are
2.5.3 Blinding                                          told to create a fist and release it without
Tester(s) will be blinded to assign the subjects to     discomfort. In a single session, the therapist did
the group. To ensure binding, subjects will be          the technique 30 times. After ten repeats, there
mandated not to reveal any details of their             will be a one-minute rest time. Each session is
treatment to the tester.                                30-60 minutes long. Mobilizations with movement
                                                        were conducted in three sets every session, five
                                                        sessions planned every week for the following
3. STUDY PROCEDURE
                                                        three weeks. The Exercise protocol of MMWM
The individuals, divided in two groups where            which will be performed is present below in the
Group A would be the experimental group, and            Table 2.
Group B will become the conventional group.
                                                        4. OUTCOME MEASURES
Prior to conducting Powerball exercises and
MMWM, both Groups will always get ultrasound            4.1 Primary Outcome Measure
[18] and the exercises [19]. Pulsed mode will be
used for Ultrasound at 1 w/cm 2 for 10 minutes            1. Patient-Rated Tennis Elbow Evaluation
using gel Binder on lateral epicondyle or at the             (PRTEE)
site of tenderness [20,21].
                                                           Before and after therapy, the PRTEE score is
     Exercises                                            used in LE patients for pain and functional
                                                           impairment     assessment.     The  PRTEE
  i. Clenching the fist powerfully                         measure is segregated into two: pain and
 ii. Resisted exercises to wrist flexor and                functional impairment [22].
     extensor muscles.
iii. Wrist pronation and supination.                      2. Hand Dynamometer
iv. Stretching wrist flexors and extensors for 30
                                                           Grip strength is measured using Hand held
     seconds at the end range
                                                           dynamometer, a special clinical tool to
                                                           determine and calculate the most intense
Each exercise written above will be performed in
                                                           isometric properties of the hand and forearm
3 series for 10 times.
                                                           muscles. Dynamometers are used to measure
                                                           hand strength in sports like baseball and
3.1 Group A (Experimental)                                 tennis, where the hand is used for flipping or
“PowerBall device”, utilized for this group for a          lifting.
strength training program that will be delivered          3. VAS
for 5 sessions per week, following 3 weeks, each
session lasts fora 20-64 minutes. Then frequency           Visual Analogue Scale (VAS), tool used for
of the "PowerBall device" will be set by total             evaluating a trait or behaviour that is
rounds per minute, which will range from 2000 to           thought to vary across a number of values
10000, depending on the subject's capacity.                and cannot be calculated directly. It is often
                                                           used in observational and clinical studies to
The exercise protocol of Powerball which will be           assess the severity or duration of pain
performed is presented below in the Table 1.               while at rest or while moving.

3.2 Group B (Control Group)                             4.2 Secondary Outcome Measure
                                                          1. Range of Motion
In this group, Mulligan Mobilisation with
movement (MMWM) will be performed in the                       It will be measured using the goniometer
patients with LE. This is a kind of manual                     instrument. It will help in measuring wrist
treatment wherein the participants lie in a supine             and elbow movements. Subjects will be
manner with their elbow extending and their                    assessed in sitting position as well as
forearm pronated, while performing continuous                  supine position with full support to the
lateral glides with concomitant physiological                  elbow. During assessment subjects should
movement to the elbow joint. The clinician stays               uncover the forearm and arm and should
by the patient's side, wrapping the belt over his              not have accessories.

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Fig. 1. Show’s the flow chart of the study

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Uttamchandani and Phansopkar; JPRI, 33(45B): 491-500, 2021; Article no.JPRI.74474

               Table 1. The Exercise protocol of PowerBall (Levels of exercise, where A - Mild, B - Moderate, C – Severe)

Weeks      Type of    Exercise (set*time)   Name of training      Rest between    Rest between        Situation Implementation           Total
           group                                                  sets            each                of Exercise                        duration of
                                                                                  exercise                                               the exercise
           A          Exercise 1:           Wrist Flexion         1 min           2 min               Sitting on the table
                      (3*30s)
           A          Exercise 2:                                                 2 min               Sitting on the table
                      (3*30s)               Wrist Extension       1 min
1st week   A          Exercise 3:           Elbow Flexion         1 min           2 min               Standing
                      (3*30s)                                                                                                            20 mins
           A          Exercise 4:           Elbow Extension                                           Standing
                      (3*30s)                                     1 min           2 min               (Trunk flexion)
           B          Exercise 1:           Wrist Flexion         1min
                      (4*45s)                                     30 sec          3 min               Sitting on the table
           B          Exercise 2:           Wrist Extension       1min            3 min               Sitting on the table
                      (4*45s)                                     30 sec
2nd week   B          Exercise 3:           Elbow Flexion         1min            3 min               Standing                           39 mins
                      (4*45s)                                     30 sec
           B          Exercise 4:           Elbow Extension       1min            3 min               Standing
                      (4*45s)                                     30 sec                              (Trunk flexion)
           C          Exercise 1:           Wrist Flexion         2 min           4 min               Sitting on the table
                      (5*60s)
           C          Exercise 2:           Wrist Extension       2 min           4 min               Sitting on the table
                      (5*60s)
3rd week   C          Exercise 3:           Elbow Flexion         2 min           4 min               Standing                           64 mins
                      (5*60s)
           C          Exercise 4:           Elbow Extension       2 min           4 min               Standing
                      (5*60s)                                                                         (Trunk flexion)

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                             Table 2. The Exercise protocol of MMWM

Week           Exercise     Rest between sets         Situation Implementation of Exercise                 Total duration
               (set*reps)
1st week       (3*10)       1 min                     Sitting on the table                                 32 mins
(5 sessions)
2nd week       (3*15)       1 min                     Sitting on the table                                 47 mins
(5 sessions)
3rd week       (3*20)       1 min                     Sitting on the table                                 62 mins
(5 sessions)

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5. DATA    COLLECTION                           AND       device and Mulligan Mobilization with movement
   MANAGEMENT                                             on patients who are having tennis elbow or LE.

5.1 Data Collection                                       3. Student’s unpaired t-test

The initial parameters variable will be used to           This test is applied on the unpaired data of the
obtain assessment information from a pre-                 independent observation made on individuals to
created database. Testing data will be put into a         see the difference between means of the control
secure REDCap database. Paper records of                  and the experimental groups.
evaluation forms, signed permission forms, and
other data will be securely maintained in the             6. DISCUSSION
research setting. Electronic information -
collected from the Hand-held dynamometer in               Our study aims to estimate the efficacy of
DMIMSU’s electronic repository as per                     PowerBall device exercises compared to the
participant ID. To enhance participant retention,         MMWM, conventional physiotherapy on LE
financial incentives will be given for attending          patients' pain and function. According to Babaei-
testing sessions. Additionally, the employment of         Mobarakeh et al. [6] resistance training with the
regular feedback concerning adherence and                 "PowerBall" increased grip strength, shoulders
reminder phone-calls (for attending the in-person         and wrists strength, performance of upper
therapy) will be done. The administrator access           extremity also proprioception in patients with
rights will lie with the principal investigators (PI).    Tennis Elbow aged 22-28 years. According to
                                                          researchers, using the "PowerBall device"
5.2 Data Management                                       resulted in enhanced power. Although it has
                                                          been proven that utilizing a dynamic PowerBall
The primary researchers will be in charge of              improves strength, function, range of motion,
collecting data and documentation. The integrity          pain due to Tennis Elbow, and QOL among
of the research information will be extensively           overhead athletes, the bulk of common concerns
examined. The Excel spreadsheet will be                   have yet to be verified. The primary (i.e. PRTEE
released at the end of the study to an allocation         index, Hand held dynamometer and VAS) and
blinded statistician for conducting the necessary         secondary (i.e. Range of motion) outcome
analysis, following which unblinding of the groups        measures will assess the efficacy PowerBall
will be done. Checklists are used to prevent              device exercises compared to the MMWM,
missing data due to the improper staff procedure.         conventional      physiotherapy      in    Lateral
                                                          epicondylitis patients pain and function. The
5.3 Statistical Analysis                                  survey's benefits provide a customized approach
                                                          to the rehabilitation protocol and the ability to
The SPSS 24.0 V software will be used and                 adapt to the individuals' improved competencies
Graph Pad Prism 7.0 V with level of significance,         during the treatment. The results of the study will
p
Uttamchandani and Phansopkar; JPRI, 33(45B): 491-500, 2021; Article no.JPRI.74474

There is no conflict of interest between the            COMPETING INTERESTS
writers and manufacturers of the goods because
we do not aim to use them as a means of                 Authors have        declared     that   no competing
pursuing legal action, but rather to promote            interests exist.
knowledge. Furthermore, the study was not
financed by the production business, but rather         REFERENCES
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