ELECTROCHEMOTHERAPY BIBLIOGRAPHY - (Up-dated January 2018) - IGEA S.p.A.

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ELECTROCHEMOTHERAPY
    BIBLIOGRAPHY
   (Up-dated January 2018)

Up-dated January 2018

   RANDOMIZED PROSPECTIVE STUDIES ON DRUG VERSUS DRUG PLUS
                     ELECTROPORATION

Byrne CM, Thompson JF, Johnston H et al. Treatment of metastatic melanoma using electroporation therapy
with bleomycin (electrochemotherapy). Melanoma Res, 2005, 15(1), 45–51

Gaudy C, Richard MA, Folchetti G, Bonerandi JJ, Grob JJ. Randomized controlled study of
electrochemotherapy in the local treatment of skin metastases of melanoma. J. Cutan. Med. Surg. 2006,
10(3), 115–121

Glass LF, Pepine ML, Fenske NA, Jaroszeski M, Reintgen DS, Heller R. Bleomycin mediated
electrochemotherapy of metastatic melanoma. Arch. Dermatol 1996, 132 (11), 1353–1357

Heller R, Jaroszeski MJ, Reintgen DS et al. Treatment of cutaneous and subcutaneous tumors with
electrochemotherapy using intralesional bleomycin. Cancer 1998, 83(1), 148–157

Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: clinical experience
in malignant melanoma patients. Clin. Cancer Res.2000, 6(3), 863–867

Clover AJ, Salwa S, McKiernan J, Buckley C, Bourke M, Kelly E.J, O'Sullivan S and Soden DM. Prospective
randomised control trial comparing electrochemotherapy and surgery for the primary treatment of basal cell
carcinoma. Abstract. 12° Congress of the European Association of Dermato‐Oncology (EADO); Vienna, 2016.
(Manuscript in preparation)

                                                                                                          1

Up-dated January 2018

THE EUROPEAN STANDARD OPERATING PROCEDURES FOR
ELECTROCHEMOTHERAPY WITH CLINIPORATOR™

Garbay JR, Billard V, Bernat C et al. Successful repetitive treatments by electrochemotherapy of multiple
unresectable Kaposi sarcoma nodules. Eur J Cancer 2006, Supplement 4:29‐31

Gehl J, Geertsen PF et al. Palliation of haemorrhaging and ulcerated cutaneous tumours using
electrochemotherapy. Eur J Cancer 2006, Supplement 4:35‐37

Marty M et al. Electrochemotherapy – an easy, highly effective and safe treatment of cutaneous and
subcutaneous metastases. Results of ESOPE (European Standard Operating Procedures of
Electrochemotherapy) study. Eur J Cancer Supplement 2006, 4:3‐13

Mir LM et al. Bases and rationale of the electrochemotherapy. Eur J Cancer 2006, Supplement 4:38‐44

Mir LM, Gehl J, Sersa G, et al. Standard operating procedures of the electrochemotherapy: Instructions for
the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by
the CliniporatorTM by means of invasive or non‐invasive electrodes. Eur J Cancer 2006, Supplement 4:14–25

Miklavcic D, Corovic S, Pucihar G et al. Importance of tumour coverage by sufficiently high local electric field
for effective electrochemotherapy. Eur J Cancer 2006, Supplement 4:45‐51

Sersa G. The state‐of‐the‐art of electrochemotherapy before the ESOPE study; advantages and clinical uses.
Eur J Cancer 2006, Supplement 4:52‐59

Snoj M et al. Long lasting complete response in melanoma treated by electrochemotherapy. Eur J Cancer
2006, Supplement 4:26‐28

Whelan MC, Larkin JO, Collins CG et al. Effective treatment of an extensive recurrent breast cancer, which
was refractory to multimodal therapy by multiple applications of electrochemotherapy. Eur J Cancer 2006,
Supplement 4:32‐34

Up-dated January 2018

BREAST CANCER METASTASES

Grischke EM, Röhm C, Stauß E, Taran FA, Brucker SY, Wallwiener D. Electrochemotherapy ‐ Supplementary
Treatment for Loco‐regional Metastasized Breast Carcinoma Administered to Concomitant Systemic
Therapy. Radiol Oncol. 2017 Jul 18;51(3):317‐323.

Bourke M, Soden D, Clover AJP Effective treatment of intractable cutaneous metastases of breast cancer with
electrochemotherapy: a useful contributor to cutaneous disease control. Breast Cancer Res Treat, 2017
163(2):403‐405

Campana LG, Galuppo S, Valpione S. Treatment of cutaneous metastases of breast cancer with
electrochemotherapy: what is the magnitude of clinical benefit? Breast Cancer Res Treat 2017, 163(2):399‐
401

Wichtowski M, Potocki P, Kufel‐Grabowska J, Streb J, Murawa D. Electrochemotherapy in the Treatment of
Massive, Multisite Breast Cancer Metastasis to the Skin and Subcutaneous Tissue: A Case Report. Breast Care
(Basel) 2017, 11(5):353‐355

Bourke MG, Salwa SP, Sadadcharam M, Whelan MC, Forde PF, Larkin JO, Collins CG, O'Reilly S, O'Sullivan GC,
Clover AJ, Soden DM. Effective treatment of intractable cutaneous metastases of breast cancer with
electrochemotherapy: Ten‐year audit of single centre experience. Breast Cancer Res Treat 2017, 161(2):289‐
297

Campana LG, Testori A, Curatolo P, Quaglino P, Mocellin S, Framarini M, Borgognoni L, Ascierto PA, Mozzillo
N, et al. Treatment efficacy with electrochemotherapy: A multi‐institutional prospective observational study
on 376 patients with superficial tumors. Eur J Surg Oncol. 2016, 42(12):1914‐1923.

Denzi A, Strigari L, Di Filippo F, Botti C, Di Filippo S, Perracchio L, Ronchetti M, Cadossi R, Liberti M. Modeling
the positioning of single needle electrodes for the treatment of breast cancer in a clinical case. Biomed Eng
Online 2016, 14 Suppl 3:S1

Cabula C, Campana LG, Grilz G, Galuppo S, Bussone R, De Meo L, Bonadies A, Curatolo P, et al.
Electrochemotherapy in the Treatment of Cutaneous Metastases from Breast Cancer: A Multicenter Cohort
Analysis. Ann Surg Oncol 2016;42(12):1914‐1923

Mercantini P, Lorenzon L, Tarantino G, Balducci G, Ferri M, Mazzuca F, Botticelli A, Marchetti P.
Electrochemotherapy treatment of cutaneous metastases from breast cancer. Am Surg. 2015, 81(5):222‐5

Campana LG, Galuppo S, Valpione S, et al. Bleomycin electrochemotherapy in elderly metastatic breast
cancer patients: clinical outcome and management considerations. J Cancer Res Clin Oncol 2014,
140(9):1557‐65

Agresti R, D’Aiuto M, De Laurentiis M, Cabula C. Electrochemotherapy for skin metastases from breast cancer:
retrospective analysis of a multicentre database (GISEL multidisciplinary group). EJC 2014, Vol 5 Supp 2 Poster
443

Schmidt G, Juhasz‐Boss I, Solomayer EF et al. Electrochemotherapy in Breast Cancer: A Review of References.
Geburtsh Frauenheilk 2014; 74: 557–562

Solari N et al. Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: A series
of 39 patients treated with palliative intent. J Surg Oncol. 2014, 109(3):270‐4

Up-dated January 2018

Kendler M, Micheluzzi M, Wetzig T et al. Electrochemotherapy under Tumescent Local Anesthesia for the
Treatment of Cutaneous Metastases. Dermatol Surg 2013, 1–10

Campana LG, Valpione s, Falci C, Mocellin S, Basso M, Corti L, Balestrieri N, Marchet A, Rossi CR. The activity
and safety of electrochemotherapy in persistent chest wall recurrence from breast cancer after mastectomy:
a phase‐II study. Breast Cancer Res Treat 2012, 134(3):1169‐78.

Matthiessen LW, Johannesen HH, Skougaard K, Gehl J, Hendel HW. Dual time point imaging fluorine‐18
flourodeoxyglucose positron emission tomography for evaluation of large loco‐regional recurrences of breast
cancer treated with electrochemotherapy. Radiol Oncol 2015, 47(4):358‐365

Cabula C. Neoadjuvant electrochemotherapy of breast cancer: our experience on first case treated in Italy.
Updates Surg 2013. 65(4):325‐8

Matthiessen LW, Johannesen HH, Hendel HW, Moss T, Kamby C & Gehl J. Electrochemotherapy for large
cutaneous recurrence of breast cancer: A phase II clinical trial. Acta Oncologica 2012; 51: 713–721

Benevento R, Santoriello A, Perna G et al. Electrochemotherapy of cutaneous metastastes from breast cancer
in elderly patients: a preliminary report. BMC Surg. 2012; 12 Suppl 1:S6.

Sersa G, Cufer T, Snezna MP, Cemazar M, Snoj M. Electrochemotherapy of chest wall breast cancer
recurrence. Cancer Treat Rev. 2012, 38(5):379‐86

Madero MV, Ortega PG Electrochemotherapy for treatment of skin and soft tissue tumours. Update and
definition of its role in multimodal therapy. Clin Transl Oncol. 2011, 13:18‐24

Matthiessen LW et al. Management of cutaneous metastases using electrochemotherapy; Acta Oncol 2011,
50(5):621‐9

Skarlatos I et al. Electrochemotherapy in Cancer Patients: First Clinical Trial in Greece. In vivo. 2011, 25: 265‐
274

Campana LG, Mocellin S, Basso M, et al. Bleomycin‐based electrochemotherapy: clinical outcome from a
single institution’s experience with 52 patients. Ann Surg Oncol 2009, 16(1):191‐9

Guida M, Porcelli G, Montemurro S. Electrochemotherapy (ECT) for the treatment of superficial tumour
metastases. EJC 2008, Supplements 6 132‐133.

Tassinari J, Orlandino G, Ardito R et al. Electrochemotherapy in oncology reconstructive surgery: five cases
preliminary report. Riv. Ital. Chir. Plastica 2008, 40, 55‐60

Larkin JO et al. Electrochemotherapy, aspects of preclinical development and early clinical experience. Ann
Surg 2007; 245: 469‐479

Whelan MC, Larkin JO, Collins CG, Cashman J, Breathnach O, Soden DM, O’Sullivan GC. Effective treatment
of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications
of electrochemotherapy. Eur J Cancer 2006, S4:32‐34

Rebersek M, Cufer T, Cezamar M, Kranjc S, Sersa G. Electrochemotherapy with Cisplatin of cutaneous tumor
lesions in breast cancer. Anti‐cancer drugs. 2004, 15:593‐597

Up-dated January 2018

Rodríguez‐Cuevas S, Barroso‐Bravo S, Almanza‐Estrada J, Cristóbal‐Martínez L, González‐Rodríguez E.
Electrochemotherapy in primary and metastatic skin tumors: phase II trial using intralesional bleomycin.
Arch Med Res. 2001, 32(4):273‐6

Rebersek M, Cufer T, Rudolf Z and Sersa G.Electrochemotherapy with cisplatin of breast cancer tumor
nodules in a male patient. Radiol Oncol. 2000, 34:357‐61

                                                                                                      5

Up-dated January 2018

HEAD AND NECK CANCERS
Plaschke CC, Bertino G, McCaul JA, Grau JJ, de Bree R, Sersa G, Occhini A, Groselj A, Langdon C, Heuveling DA,
Cemazar M, Strojan P, Leemans CR, Benazzo M, De Terlizzi F, Wessel I, Gehl J. European Research on
Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal
cancers. Eur J Cancer. 2017;87:172‐181

Gargiulo M, Cortese A, Pantaleo G, Parascandalo S, Amato M. A relapsed lower lip squamous cell carcinoma
treated with curative electrochemotherapy in elderly patient. Minerva Stomatol. 2017 [Epub ahead of print]

Bertino G, Sersa G, De Terlizzi F, Occhini A, et al. European Research on Electrochemotherapy in Head and
Neck Cancer (EURECA) project: Results of the treatment of skin cancer European Journal of Cancer 2016, 63
(41‐52)

Groselj A, Krzan M, Kosjek T, Bosnjak M, Sersa G, Cemazar M. Bleomycin pharmacokinetics of bolus bleomycin
dose in elderly cancer patients treated with electrochemotherapy. Cancer Chemother Pharmacol 2016,
77(5):939‐47

Montuori M, Santurro L, Feliziani A, DE Sanctis F, Ricciardi E, Gaudio D, Campione E, Bianchi L, Silvi MB, Rossi
P. Electrochemotherapy for basocellular and squamocellular head and neck cancer: preliminary experience
in day surgery unit. G Ital Dermatol Venereol 2016, Jul 5. [Epub ahead of print]

Rotunno R, Marenco F, Ribero S, Calvieri S, Amerio P, Curatolo P, Quaglino P..Electrochemotherapy in non‐
melanoma head and neck skin cancers: a three centers experience and literature review. G Ital Dermatol
Venereol G Ital Dermatol Venereol 2016, 151(6):610‐618

Landström FJ, Reizenstein JA, S Nilsson CO, Beckerath MV, Löfgren AL, Adamsson GB, Möller C
Electrochemotherapy ‐ possible benefits and limitations to its use in the head and neck region Acta
Otolaryngol 2015, 135(1):90‐5

Landström FJ, Nilsson CO, Crafoord S, Reizenstein JA, Adamsson GB, Löfgren LA. Electroporation therapy of
skin cancer in the head and neck area. Dermatol Surg. 2010, 36(8):1245‐50

Domanico R, Trapasso S, Santoro M, Pingitore D, Allegra E. Electrochemotherapy in combination with
chemoradiotherapy in the treatment of oral carcinomas in advanced stages of disease: efficacy, safety, and
clinical outcomes in a small number of selected cases. Drug Des Devel Ther. 2015, 19; 9:1185‐91

Quaglino P, Matthiessen LW, Curatolo P, Muir T, Bertino G, Kunte C, Odili J, Rotunno R, Humphreys AC, Letulé
V, Marenco F, Cuthbert C, Albret R, Benazzo M, De Terlizzi F, Gehl J. Predicting patients at risk for pain
associated with electrochemotherapy. Acta Oncol 2015 Mar; 54(3):298‐306

Campana LG, Mali B, Sersa G et al. Electrochemotherapy in non‐melanoma head and neck cancers: a
retrospective analysis of the treated cases. Br J Oral Maxillofac Surg. 2014, 52(10):957‐64

Cymerman J, Kulkarni R, Panagiotis T et al. Electrochemotherapy in Head & Neck Oncology: Bradford’s
contribution to the EURECA Trial. Br J Oral Maxillofac Surg 2014

Macri GF, Greco A, Gallo A et al. Use of electrochemotherapy in a case of neck skin metastasis of oral
squamous cell carcinoma: Case report and considerations. Head Neck. 201436(9):E86‐90

Seccia V et al. Electrochemotherapy and Its Controversial Results in Patients with Head and Neck Cancer.
Anticancer Research 2014, 34:967‐972

Up-dated January 2018

Solari N et al. Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: A series
of 39 patients treated with palliative intent. J Surg Oncol 2014, 109(3):270‐4

Campana LG, Bertino G, Rossi CR, Occhini A, Rossi M, Valpione S, Benazzo M. The value of
electrochemotherapy in the treatment of peristomal tumors. Eur J Surg Oncol 2014, 40(3):260‐2

De Virgilio A, Fusconi M, Greco A, de Vincentiis M.The role of electrochemotherapy in the treatment of
metastatic head and neck cancer. Tumori 2013, 99(5):634

Kyrgias G, Kostopoulou E, Zafiriou E, Zygogianni A, Skarlatos J, Roussaki‐Schulze A, Theodorou K.
Hidradenocarcinoma of the temporal area successfully treated with concomitantelectrochemotherapy and
radiotherapy Head Neck Oncol 2013, 5(2):14

Benevento R et al. Electrochemotherapy of cutaneous metastases from breast cancer in elderly patients: a
preliminary report. BMC Surgery 2012, 12(Suppl 1):S6

Gargiulo M et al. Electrochemotherapy for Non‐Melanoma Head and Neck Cancers Clinical Outcomes in 25
Patients. Ann Surg 2012, .255:1158–1164

Mevio N et al. Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary
results. Tumori 2012, 98: 308‐313

Madero MV, Ortega PG Electrochemotherapy for treatment of skin and soft tissue tumours. Update and
definition of its role in multimodal therapy. Clin Transl Oncol 2011, 3:18‐24

Matthiessen LW et al. Management of cutaneous metastases using electrochemotherapy; Acta Oncol. 2011,
50(5):621‐9

Skarlatos I, Kyrgias G, Mosa E, Provatopoulou X, Spyrou M, Theodorou K, Lepouras A, Gounaris A,
Koukourakis M. Electrochemotherapy in Cancer Patients: First Clinical Trial in Greece. In vivo 2011, 25: 265‐
274

Landström FJ, Nilsson CO, Crafoord S, et al Electroporation therapy of skin cancer in the head and neck area.
Dermatol Surg 2010, 36:1245‐50

Gargiulo M, Moio M, Monda G, Parascandolo S, Cubicciotti G. Electrochemotherapy:Actual Considerations
and Clinical Experience in Head and Neck Cancers. Annals of Surgery 2010, 251: 4

Campana LG, Mocellin S, Basso M, et al. Bleomycin‐based electrochemotherapy: clinical outcome from a
single institution’s experience with 52 patients. Ann Surg Oncol 2009, 16(1):191‐9

Guida M, Porcelli G, Montemurro S. Electrochemotherapy (ECT) for the treatment of superficial tumour
metastases. EJC 2008, Supplements 6132‐133

Tassinari J, Orlandino G, Ardito R et al. Electrochemotherapy in oncology reconstructive surgery: five cases
preliminary report. Riv. Ital. Chir. Plastica 2008, 40, 55‐60

Larkin JO et al. Electrochemotherapy, aspects of preclinical development and early clinical experience. Ann
Surg 2007, 245: 469‐479

Up-dated January 2018

Bloom DC, Goldfarb PM The role of intratumour therapy with electroporation and bleomycin in the
management of advanced squamous cell carcinoma of the head and neck. EJSO 2005, 31:1029‐1035

Burian M, Formanek M, Regele H Electroporation Therapy in Head and Neck Cancer Acta Otolaryngol 2003,
123:264‐268

Panje WR, Hier MP, Garman GR, Harrell E, Goldman A, Bloch I. Electroporation therapy of head and neck
cancer. Ann Otol Rhinol Laryngol 1998, 107:779‐85.

Mir LM, Glass LF, Sersa G, Teissié J, Domenge C, et al. Effective treatment of cutaneous and subcutaneous
malignant tumours by electrochemotherapy.Br J Cancer 1998, 77(12):2336‐42

Domenge C, Orlowski S, Luboinski B, De Baere T, Schwaab G, Belehradek J Jr,Mir LM. Antitumor
electrochemotherapy: new advances in the clinical protocol. Cancer 1996, 77(5):956‐63

Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J Jr, Mir LM. Electrochemotherapy, a new
antitumor treatment. First clinical phase I‐II trial. Cancer 1993, 15; 72(12):3694‐700

Mir LM, Belehradek M, Domenge C, Orlowski S, Poddevin B, Belehradek J Jr, Schwaab G, Luboinski B, Paoletti
C. Electrochemotherapy, a new antitumor treatment: first clinical trial CRAS 1991, III, 613‐618

Reduced Bleomycin Dose
Rotunno R, Campana LG, Quaglino P, de Terlizzi F, Kunte C, Odili J, Gehl J, Ribero S, Liew SH, Marconato R,
Brizio M, Curatolo P. Electrochemotherapy of unresectable cutaneous tumors with reduced dosages of
intravenous bleomycin: analysis of 57 patients from the InspECT (International network for sharing practices
of ElectroChemoTherapy) registry. J Eur Acad Dermatol Venereol. 2017 [Epub ahead of print]

Groselj A, Bosnjak M, Strojan P, Krzan M, Cemazar M, Sersa G Efficiency of electrochemotherapy with
reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: Preliminary results.
Head & Neck. 2017;1–6

Up-dated January 2018

METASTATIC MELANOMA
Kunte C, Letulé V, Gehl J, Dahlstroem K, Curatolo P, Rotunno R, Muir T, Occhini A, Bertino G, Powell B, et al.
Electrochemotherapy in the treatment of metastatic malignant melanoma: a prospective cohort study by
InspECT. Br J Dermatol 2017, [Epub ahead of print]

Giulia Bertino, Gregor Sersa, Francesca De Terlizzi, Antonio Occhini, et al. European Research on
Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer.
European Journal of Cancer 2016, 63 (41‐52)

Campana LG, Testori A, Curatolo P, Quaglino P, Mocellin S, Framarini M, Borgognoni L, Ascierto PA, Mozzillo
N, Guida M, Bucher S, Rotunno R, Marenco F, De Salvo GL, De Paoli A, Rossi CR, Bonadies A. Treatment
efficacy with electrochemotherapy: A multi‐institutional prospective observational study on 376 patients
with superficial tumors. Eur J Surg Oncol. 2016, 42(12):1914‐1923

Bigi L, Galdo G, Cesinaro AM, Vaschieri C, Marconi A, Pincelli C, Fantini F Electrochemotherapy induces
apoptotic death in melanoma metastases: a histologic and immunohistochemical investigation. Clin Cosmet
Investig Dermatol 2016, 9:451‐459

Tomassini GM, Covarelli P, Tomassini MA, Corsi A, Bianchi L, Hansel K, Stingeni L. Electrochemotherapy with
intravenous bleomycin for advanced non‐melanoma skin cancers and for cutaneous and subcutaneous
metastases from melanoma. G Ital Dermatol Venereol. 2016, 151(5):499‐506

Heppt MV, Eigentler TK, Kähler KC, Herbst RA, Göppner D, Gambichler T, Ulrich J, Dippel E, Loquai C, Schell
B, Schilling B, Schäd SG, Schultz ES, Matheis F, Tietze JK, Berking C. Immune checkpoint blockade with
concurrent electrochemotherapy in advanced melanoma: a retrospective multicenter analysis. Cancer
Immunol Immunother 2016, 65(8):951‐9

Hribernik A, Cemazar M, Sersa G, Bosnjak M, Snoj M. Effectiveness of electrochemotherapy after IFN‐α
adjuvant therapy of melanoma patients. Radiol Oncol 2016, 50(1):21‐7

Mozzillo N, Simeone E, Benedetto L, Curvietto M, Giannarelli D, Gentilcore G et al. Assessing a novel immuno‐
oncology‐based combination therapy: Ipilimumab plus electrochemotherapy. OncoImmunology 2015, 4:6,
1008842

Caracò C, Marone E, Simeone E, Grimaldi AM, Botti G, Del Giudice M, Ascierto PA & Mozzillo N.
Electrochemotherapy in melanoma patients: a single institution experience. Melanoma Manag 2015, 2(2),
127–132

Brizio M, Fava P, Astrua C, Cavaliere G, Savoia P Complete regression of melanoma skin metastases after
electrochemotherapy plus ipilimumab treatment: an unusual clinical presentation. Eur J Dermatol 2015,
25(3):271‐2

Valpione S, Campana LG, Pigozzo J, Chiarion‐Sileni V. Consolidation electrochemotherapy with bleomycin in
metastatic melanoma during treatment with dabrafenib. Radiol Oncol 2015, 3; 49 (1):71‐4

Gatti A, Stinco G, di Meo N, Bergamo S, Trevisan G. Curative Electrochemotherapy in Lentigo Maligna
Melanoma. Skinmed 2015, 13(6):486‐8. eCollection

Up-dated January 2018

Ricotti F, Giuliodori K, Cataldi I, Campanati A, Ganzetti G, Ricotti G, Offidani A. Electrochemotherapy: an
effective local treatment of cutaneous and subcutaneous melanoma metastases. Dermatol Ther 2014,
27(3):148‐52

Solivetti FM, Desiderio F, Guerrisi A, Bonadies A, Maini CL, Di Filippo S, D'Orazi V, Sperduti I, Di Carlo A. HF
ultrasound vs PET‐CT and telethermography in the diagnosis of In‐transit metastases from melanoma: a
prospective study and review of the literature. J Exp Clin Cancer Res 2014, 33(1):96

Mir‐Bonafé JM, Vilalta A, Alarcón I, Carrera C, Puig S, Malvehy J, Rull R, Bennàssar A Electrochemotherapy in
the Treatment of Melanoma Skin Metastases: A Report on 31 Cases.Actas Dermosifiliogr. 2015, 106(4):285‐
91

Carrera C, Bennassar A, Ishioka P et al. Desmoplastic melanoma on the nose: electrochemotherapy as an
alternative treatment to local advanced disease. J Eur Acad Dermatol Venereol. 2014, 28(4):424‐32.

Solari N et al. Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: A series
of 39 patients treated with palliative intent. J Surg Oncol 2014, 109(3):270‐4

Simeone E, Benedetto L, Gentilcore G, Caraco C, Di Monta G, Grimaldi AM, Esposito A, Capone M, Di Marone
U, Curvietto M, Di Madonna G, Di Cecilia M, Di Mori S, Mozzillo N, Ascierto PA. Combination therapy with
ipilimumab and electrochemotherapy: Preliminary efficacy results and correlation with immunologic
parameters. J Clin Oncol 2013, e20031

Caracò C, Mozzillo N, Marone U, Simeone E, Benedetto L, Di Monta G, Di Cecilia ML, Botti G, Ascierto PA.
Long‐lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis. BMC
Cancer 2013, 13(1):564

Gerlini G, Sestini S, Di Gennaro P, Urso C, Pimpinelli N, Borgognoni L. Dendritic cells recruitment in melanoma
metastasis treated by electrochemotherapy. Clin Exp Metastasis 2013, 30(1):37‐45

Kendler M, Micheluzzi M, Wetzig T et al. Electrochemotherapy under Tumescent Local Anesthesia for the
Treatment of Cutaneous Metastases. Dermatol Surg 2013; 1–10

Ferreira DM, Saga YY, Aluicio‐Sarduy E, Tedesco AC Chitosan Nanoparticles for Melanoma Cancer Treatment
by Photodynamic Therapy and Electrochemotherapy Using Aminolevulinic Acid Derivatives Curr Med Chem
2013 20(14):1904‐11

Campana LG et al. Electrochemotherapy for disseminated superficial metastases from malignant melanoma.
British Journal of Surgery 2012, 99(6):821‐30

Gerlini G, Di Gennaro P, Borgognoni L. Enhancing anti‐melanoma immunity by electrochemotherapy and in
vivo dendritic‐cell activation. OncoImmunology 1:9, 1655–1657; 2012

Mozzillo N et al. Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a
patient with melanoma. Journal of Translational Medicine 2012, 10:131

Matthiessen LW et al. Management of cutaneous metastases using electrochemotherapy; Acta Oncol 2011,
0(5):621‐9

Kis E et al. Electrochemotherapy of Cutaneous Metastases of Melanoma ‐ A Case Series Study and Systematic
Review of the Evidence. Dermatol Surg 2011; 37:1–9

Quaglino P, Osella‐Abate S, Marenco F, et al. FoxP3 expression on melanoma cells is related to early visceral
spreading in melanoma patients treated by electrochemotherapy. Pigment Cell & Melanoma Research, 2011,
24 (4), 734‐736

Up-dated January 2018

Madero MV, Ortega PG Electrochemotherapy for treatment of skin and soft tissue tumours. Update and
definition of its role in multimodal therapy. Clin Transl Oncol 2011, 13:18‐24.

Skarlatos I, Kyrgias G, Mosa E, Provatopoulou X, Spyrou M, Theodorou K, Lepouras A, Gounaris A, Koukourakis
M. et al. Electrochemotherapy in Cancer Patients: First Clinical Trial in Greece. In vivo 2011, 25: 265‐274

Gehl J,Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by
electrochemotherapy. Melanoma Res 2010, 10(6):585‐9

Kaehler KC, Egberts F, Hauschild A. Electrochemotherapy in symptomatic Melanoma Skin Metastases: intra
individual comparison with conventional surgery. Dermatol Surg 2010; 36(7):1200‐2

Snoj M, Cemazar M, Srnovrsnik T, Kosir SP, Sersa G. Limb sparing treatment of bleeding melanomarecurrence
by electrochemotherapy. Tumori 2009, 95: 398‐402

Tauceri F, Mura G, Framarin M et al. Treatment with electrochemotherapy of cutaneous or sub‐cutaneous
metastases non responders to conventional therapy: our preliminary experience in 5 patients. Minerva
Chirur 2008, 63(Suppl 1‐3).227‐9.

Testori A, Faries MB, Thompson JF, Pennacchioli E, Deroose JP, van Geel AN, Verhoef C, Verrecchia F, Soteldo
J. Local and Intralesional Therapy of In‐Transit Melanoma Metastases. Journal of Surgical Oncology 2011;
104:391–396

Matthiessen LW, Chalmers RL, Sainsbury DC, Veeramani S, Kessell G, Humphreys AC, Bond JE, Muir T, Gehl J.
Management of cutaneous metastases using electrochemotherapy. Acta Oncol 2011, 50(5):621‐9

Farricha V, Vasques H, Carvalhal S and Mendes deAlmeida JC. Electrochemotherapy: two years of experience
in a cancer center. Melanoma Research 2010, Vol 20 e‐Supplement A

Cavalcanti A, Souadka A, Mateus C, Mir L, Robert C. Clinical experience with eletrochemotherapy (ECT) in the
skin melanoma metastases. European Journal of Surgical Oncology 2010, 36:9 (909)

Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, Kropivnik M, Bracko M, Pecnik T, Gadzijev E, Sersa G.
Towards treatment planning and treatment of deep‐seated solid tumors by electrochemotherapy. Biomed
Eng Online 2010, 9:10

Savoia P et al. Skin metastases of malignant melanoma: a clinical and prognostic survey. Melanoma Research
2009, 19:321–326.

Campana LG, Mocellin S, Basso M, et al. Bleomycin‐based electrochemotherapy: clinical outcome from a
single institution’s experience with 52 patients. Ann Surg Oncol. 2009, 16(1):191‐9

Guida M, Porcelli G, Montemurro S. Electrochemotherapy (ECT) for the treatment of superficial tumour
metastases. EJC 2008, Supplements 6, 132‐133

Quaglino P et al. Electrochemotherapy with Intravenous Bleomycin in the Local Treatment of Skin Melanoma
Metastases. Annals Surg Oncol 2008; 15(8):2215‐22

Larkin JO, Collins CG, Aarons S, Tangney M, Whelan M, O'Reily S, Breathnach O, Soden DM, O'Sullivan GC.
Electrochemotherapy, aspects of preclinical development and early clinical experience. Ann Surg 2007, 245:
469‐479

Snoj M, Cemazar M, Slekovec Kolar B, Sersa G.Effective Treatment of Multiple Unresectable Skin Melanoma
Metastases by Electrochemotherapy‐Croat Med J‐2007, 48:391‐395

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Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, Billard V, Geertsen PF et al. Electrochemotherapy –
an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases. Results of ESOPE
(European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer 2006, Sup 4: 3‐13

Byrne CM, Thompson JF. Role of electrochemotherapy in the treatment of metastatic melanoma and other
metastatic and primary skin tumors. Expert Rev Anticancer Ther 2006, (5):671‐8

Byrne CM, Thompson JF, Johnston H, Hersey P, Quinn MJ, Hughes TM and McCarthy WH.Treatment of
metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma
Research 2005, 15:45–51

Gaudy C, Richard MA, Folchetti G, Bonerandi JJ, Grob JJ Randomized Controlled Study of
Electrochemotherapy in the Local Treatment of Skin Metastases of Melanoma. J of Cutaneous Medicine and
Surgery 2006, 10:1‐7

Gehl J, Geertsen PF. Palliation of haemorrhaging and ulcerated cutaneous tumours using
electrochemotherapy. Eur J Cancer 2006, S4:35‐37

Snoj M, Rudolf Z, Paulin‐Kosir SM, Cemazar M, Snoj R, Sersa G. Long lasting complete response in melanoma
treated by electrochemotherapy. Eur J Cancer 2006; 4 (Suppl):26–28

Glass LF, Pepine ML, Fenske NA, Jaroszeski M, Reintgen DS, Heller R. Bleomycin‐Mediated
Electrochemotherapy of Metastatic Melanoma. Arch Dermatol 2006, 156:1353‐1357

Snoj M, Rudolf Z, Cemazar M et al. Successful sphincter‐saving treatment of anorectal malignant melanoma
with electrochemotherapy, local excision and adjuvant brachytherapy. Anti‐Cancer Drugs, 2005, 16:345–348

Andersen MH, Gehl J, Reker S, Pedersen LO, Becker JC, Geertsen P, Straten P. Dynamic changes of specific T
cell responses to melanoma correlate with IL‐2 administration.Semin Cancer Biol 2003, 13:449‐459

Rodríguez‐Cuevas S, Barroso‐Bravo S, Almanza‐Estrada J, Cristóbal‐Martínez L, González‐Rodríguez E.
Electrochemotherapy in primary and metastatic skin tumors: phase II trial using intralesional bleomycin. Arch
Med Res. 2001, 32(4):273‐6.

Gehl J, Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by
electrochemotherapy. Melanoma Research 2000, 10:585‐589

Rols MP, Bachaud JM, Giraud P, Chevreau C, Rouché H, Teissié J. Electrochemotherapy of cutaneous
metastases in malignant melanoma. Melanoma Research 2000, 10: 468‐474

Sersa G, Stabuc B, Cemazar M, Miclavcic D, and Rudolf Z. Electrochemotherapy with Cisplatin: Clinical
Experience in Malignant Melanoma Patients. Clinical Cancer Research 2000, 6:863‐867

Sersa G, Stabuc B, Cemazar M, Miklavcic D and Rudolf Z. Electrochemotherapy with cisplatin: the systemic
antitumor effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the
treatment of malignant melanoma skin metastases. Melanoma Research 2000, 10:381‐385

Mir LM, Glass LF, Sersa G, Teissié J, Domenge C, Miklavcic D, Jaroszeski MJ, Orlowski S, Reintgen DS, Rudolf
Z, Belehradek M, Gilbert R, Rols MP, Belehradek J Jr, Bachaud JM, DeConti R, Stabuc B, Cemazar M, Coninx
P, Heller R. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.
Br J Cancer 1998, 77(12):2336‐42

Heller R, Jaroszeski MJ, Reintgen DS et al. Treatment of cutaneous and subcutaneous tumors with
electrochemotherapy using intralesional bleomycin. Cancer 1998, 83(1), 148–157

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Glass LF, Pepine ML, Fenske NA, Jaroszeski M, Reintgen DS, Heller R. Bleomycin‐mediated
electrochemotherapy of metastatic melanoma. Arch Dermatol 1996, 132(11):1353‐7

Heller R, Jaroszeski MJ, Glass LF, Messina JL, Rapaport DP, DeConti RC, Fenske NA, Gilbert RA, Mir LM,
Reintgen DS. Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using
electrochemotherapy. Cancer 1996, 77(5):964‐71

Giraud P, Bachaud JM, Teissie J, Rols MP. Effects of electrochemotherapy on cutaneous metastases of human
malignant melanoma. Int J Radiat Oncol Biol Phys. 1996, 1; 36(5):1285

Rudolf Z, Stabuc B, Cemazar M, Miklavcic D, Vodovnic L and Sersa G. Electrochemotherapy with bleomicyn.
The first clinical experience in malignant melanoma patient. Radiol Oncol 1995, 29:229‐35

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Metastatic Melanoma Combined Treatment
Karaca B, Yayla G, Erdem M, Gürler T. Electrochemotherapy with anti‐PD‐1 treatment induced durable
complete response in heavily pretreated metastatic melanoma patient. Anticancer Drugs. 2017 [Epub ahead
of print]

Hribernik A, Cemazar M, Sersa G, Bosnjak M, Snoj M. Effectiveness of electrochemotherapy after IFN‐α
adjuvant therapy of melanoma patients. Radiol Oncol 2016, 50(1):21‐7

Valpione S, Campana LG, Pigozzo J, Chiarion‐Sileni V. Consolidation electrochemotherapy with bleomycin in
metastatic melanoma during treatment with dabrafenib. Radiol Oncol 2015, 3; 49 (1):71‐4

Mozzillo N et al. Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a
patient with melanoma. Journal of Translational Medicine 2012, 10:131

Gerlini G, Sestini S, Di Gennaro P, Urso C, Pimpinelli N, Borgognoni L. Dendritic cells recruitment in melanoma
metastasis treated by electrochemotherapy. Clin Exp Metastasis 2013, 30(1):37‐45

Gerlini G, Di Gennaro P, Borgognoni L. Enhancing anti‐melanoma immunity by electrochemotherapy and in
vivo dendritic‐cell activation. OncoImmunology 1:9, 1655–1657; 2012

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NON MELANOMA SKIN CANCERS
Basal Cell Carcinoma and Squamous Cell Carcinoma
Campana LG, Marconato R, Valpione S, Galuppo S, Alaibac M, Rossi CR, Mocellin S.Basal cell carcinoma: 10‐
year experience with electrochemotherapy. J Transl Med 2017, 15(1):122

Di Monta G, Caracò C, Simeone E, Grimaldi AM, Marone U, Di Marzo M, Vanella V, Festino L, Palla M, Mori S,
Mozzillo N, Ascierto PA. Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III
cutaneous squamous cell carcinoma: a 22‐cases retrospective analysis. J Transl Med 2017, 26; 15(1):82

Sommerlad M, Lock A, Moir G, McGregor J, Bull R, Cerio R, Harwood C. Linear porokeratosis with multiple
squamous cell carcinomas successfully treated by electrochemotherapy. Br J Dermatol 2016, 175 (6), 1342‐
1345

Diociaiuti A, Rotunno R, El Hachem M, Latorre S, Cozza R, Curatolo P. Electrochemotherapy, a potential new
treatment for the management of squamous cell carcinoma in patients with recessive dystrophic
epidermolysis bullosa: report of three cases. J Eur Acad Dermatol Venereol 2016, (7):1195‐6

Ruggeri R, et al. Electrochemotherapy: a good idea in recurrent basal cell carcinoma treatment. Melanoma
Manag. 2015, 2(1), 27–31

Ricci F, Paradisi A, Fossati B, Mancini M, Curatolo P, Guerriero C, Capizzi R. Giant neglected squamous cell
carcinoma of the skin. Dermatol Ther. 2015, 28(4):230‐4

Kreuter A, van Eijk T, Lehmann P, Fischer M, Horn T, Assaf C, Schley G, Herbst R, Kellner I, Weisbrich C, Hyun
J, Wieland U, Schlaak M, Rübben A, Lommel K. Electrochemotherapy in advanced skin tumors and cutaneous
metastases – a retrospective multicenter analysis. J Dtsch Dermatol Ges 2015, 13(4):308‐15

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Landström FJ, Reizenstein J, Adamsson GB, Beckerath Mv, Möller C. Long‐term follow‐up in patients treated
with curative electrochemotherapy for cancer in the oral cavity and oropharynx. Acta Otolaryngol. 2015;
135(10):1070‐8

Ruggeri R, Maurichi A, Tinti MC, Cadenelli P, Patuzzo R, Gallino G & Santinami M. Electrochemotherapy: a
good idea in recurrent basal cell carcinoma treatment. Melanoma Management 2015, 2 (1): 27‐31

Solari N et al. Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: A series
of 39 patients treated with palliative intent. J Surg Oncol. 2014 Mar; 109(3):270‐4

Gatti A, Stinco G, di Meo N, Noal C, Maione V, Trevisan G. Electrochemotherapy for a locally advanced basal
cell carcinoma on the forehead. Indian J Dermatol Venereol Leprol. 2014, 80(4):378‐80

Campana LG et al. Electrochemotherapy Treatment of Locally Advanced and Metastatic Soft Tissue Sarcomas:
Results of a Non‐Comparative Phase II Study. World J Surg. 2014, 38(4):813‐22

Macri GF et al. Use of electrochemotherapy in a case of neck skin metastasis of oral squamous cell carcinoma.
A case report and considerations. Head Neck 2014, (9):E86‐90

Salwa SP et al. Electrochemotherapy for the treatment of ocular basal cell carcinoma; a novel adjunct in the
disease management. J Plast Reconstr Aesthet Surg. 2014, 67(3):403‐6

Seccia V et al. Electrochemotherapy and its controversial results in patients with head and neck cancer.
Anticancer Res. 2014, (2):967‐72

Benevento R et al. Electrochemotherapy of head and neck cancer in elderly patients: a preliminary report.
BMC Surgery 2013, 13(Suppl 1):A5

Kendler M et al. Electrochemotherapy Under Tumescent Local Anesthesia for the Treatment of Cutaneous
Metastases. Dermatol Surg 2013; 1–10

Gargiulo M et al. Electrochemotherapy for Non‐Melanoma Head and Neck Cancers Clinical Outcomes in 25
Patients. Ann Surg 2012, 255:1158–1164

Mevio N et al. Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary
results. Tumori. 2012, 98: 308‐313

Macripò G, Caliendo V, Grassi M et al. Squamous cell carcinoma of the umbilicus: management of an unusual
localization. Tumori. 2011, 97: 236‐238

Madero MV, Ortega PG Electrochemotherapy for treatment of skin and soft tissue tumours. Update and
definition of its role in multimodal therapy. Clin Transl Oncol. 2011, 13:18‐24

Marenco F, Nardò T, Savoia P, Bernengo MG. Effectiveness of electrochemotherapy in treatment of a
recurrent squamous cell carcinoma of the scalp. Eur J Dermatol. 2011, 21(4):618‐9

Matthiessen LW, Chalmers RL, Sainsbury DC, Veeramani S, Kessell G, HumphreysAC, Bond JE, Muir T, Gehl J.
. Management of cutaneous metastases using electrochemotherapy; Acta Oncol. 2011, 5 0(5):621‐9

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Testori A,Faries M, Thompson JF, Pennacchioli E, Deroose JP, van Geel MD AN, Verhoef C, Verrecchia F,
Soteldo J Local and Intralesional Therapy of In‐Transit Melanoma Metastases. Journal of Surgical Oncology
2011, 104:391–396

Campana LG, Mocellin S, Basso M, et al. Bleomycin‐based electrochemotherapy: clinical outcome from a
single institution’s experience with 52 patients. Ann Surg Oncol 2009, 16(1):191‐9

Fantini F, Gualdi G, Cimitan A, Giannetti A. Metastatic basal cell carcinomawith squamous differentiation:
report of a case with response of cutaneousmetastases to electrochemotherapy. Arch Dermatol. 2008,
144(9):1186‐8

Tassinari J, Orlandino G, Ardito R et al. Electrochemotherapy in oncology reconstructive surgery: five cases
preliminary report. Riv. Ital. Chir. Plastica 2008, 40, 55‐60

Larkin JO, Collins CG, Aarons S, Tangney M, Whelan M, O'Reily S, Breathnach O,Soden DM, O'Sullivan GC.
Electrochemotherapy: aspects of preclinical development and early clinical experience. Ann Surg. 2007,
245(3):469‐79

Bloom DC, Goldfarb PM The role of intratumour therapy with electroporation and bleomycin in the
management of advanced squamous cell carcinoma of the head and neck. EJSO 2005, 31:1029‐1035

Burian M, Formanek M, Regele H. Electroporation Therapy in Head and Neck Cancer Acta Otolaryngol 2003,
123:264‐268

Glass LF, Fenske NA, Jaroszeski M, Perrott R, Harvey DT, Reintgen DS, Heller R. Bleomycin‐mediated
electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol. 1996, 34(1):82‐6

Mir LM, Glass LF, Sersa G, Teissié J, Domenge C, et al. Effective treatment of cutaneous and subcutaneous
malignant tumours by electrochemotherapy.Br J Cancer. 1998, 77(12):2336‐42

Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, Glass LF. Treatment of Cutaneous and
Subcutaneous Tumors with Electrochemotherapy Using Intralesional BleomycinCancer 1998, 83:148‐157

Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z.Electrochemotherapy with cisplatin:
potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients.
Eur J Cancer.1998, 34(8):1213‐8

Heller R, Jaroszeski MJ, Glass LF, Messina JL, Rapaport DP, DeConti RC, Fenske NA, Gilbert RA, Mir LM,
Reintgen DS. Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using
electrochemotherapy. Cancer. 1996, 1;77(5):964‐71

Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J Jr, Mir LM. Electrochemotherapy, a new
antitumor treatment. First clinical phase I‐II trial. Cancer 1993, 72(12):3694‐700

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Merkel Cell Carcinoma
Holdsworthb R, SLiewa S. Electrochemotherapy for treatment of Merkel cell carcinoma: A case report JPRAS
Open 6 (2015) 49e52

Solari N, Spagnolo F, Ponte E, Quaglia A, Lillini R, Battista M, Queirolo P, Cafiero F. Electrochemotherapy for
the management of cutaneous and subcutaneous metastasis: a series of 39 patients treated with palliative
intent. J Surg Oncol. 2014 Mar;109(3):270‐4.

Curatolo P, Rotunno R, Miraglia E, Mancini M, Calvieri S, Giustini S. Complete remission of Merkel cell
carcinoma treated with electrochemotherapy and etoposide. G Ital Dermatol Venereol. 2013, 148(3):310‐1

Scelsi D, Mevio N , Bertino G, Occhini A , Brazzelli V, Morbini P , Benazzo B.Electrochemotherapy as a new
therapeutic strategy in advanced Merkel cell carcinoma of head and neck region. Radiol Oncol. 2013,
47(4):366‐369

Mevio N, Bertino G, Occhini A, Scelsi D, Tagliabue M, Mura F, Benazzo M. Electrochemotherapy for the
treatment of recurrent head and neck cancers: preliminary results. Tumori. 2012, 98(3):308‐13

Curatolo P, Mancini M, Clerico R, Ruggiero A, Frascione P, Di Marco P, Frasca M, Calvieri S. Remission of
extensive merkel cell carcinoma after electrochemotherapy. Arch Dermatol. 2009 Apr;145(4):494‐5

Kaposi Sarcoma
Starita N, Di Monta G, Cerasuolo A, Marone U, Anniciello AM, Botti G, Buonaguro L, Buonaguro FM,
Tornesello ML. Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma.
Infect Agent Cancer 2017, 12:35

Di Monta G., Caracò C, Benedetto L et al. Electrochemotherapy as “new standard of care” treatment for
cutaneous Kaposi’s sarcoma. European E Journal of Surgery 2014, 40 (1): 61-66

Latini A, Bonadies A, Trento E, Bultrini S, Cota C, Solivetti FM, Ferraro C, Ardigò M, Amorosi B, Palamara
G, Bucher S, Giuliani M, Cordiali-Fei P, Ensoli F and Di Carlo A. Effective treatment of Kaposi's sarcoma
by electrochemotherapy and intravenous bleomycin administration. Dermatologic Therapy 2012, 25(2): 214–
218

Curatolo P, Quaglino P, Marenco F, Mancini M, Nardo` T, Mortera C, Rotunno R, Calvieri A, Bernengo MG.
Electrochemotherapy in the treatment of Kaposi sarcoma Cutaneous lesions: A two-center prospective phase
II trial. Annals of Surgical Oncology 2012, 19 (1), 192-198

Gualdi G, Monari P, Fantini F, Cesinaro AM, Cimitan. Electrochemotherapy-induced virus disappearance in
HHV-8-positive skin nodules of Kaposi sarcoma: first histological and immunohistochemical demonstration
of efficacy.A.J Eur Acad Dermatol Venereol. 2010, 24(2):239-41

Curatolo P, Mancini M, Ruggiero A, Clerico R, Di Marco P and Calvieri S. Successful Treatment of Penile
Kaposi's Sarcoma with Electrochemotherapy. Dermatologic Surgery 2008, 34, (6): 839–843

Tauceri F et al. Treatment with electrochemotherapy of cutaneous or sub‐cutaneous metastases non‐
responders to conventional therapy: our preliminary experience in 5 patients. Minerva Chirur 2008, 63(Suppl
1‐3).227‐9

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Garbay JR, Billard V, Bernatc C, Mirc LM, Morslic N, Roberte C. Successful repetitive treatments by
electrochemotherapy of multiple unresectable Kaposi sarcoma nodules. EJC 2006, Sup 4: 29‐31

Gorlin-Goltz
Curatolo P, Miraglia E, Rotunno R, Calvieri S, Giustini S. Electrochemotherapy: a valid treatment for Gorlin‐
Goltz syndrome. Acta Dermatovenerol Croat. 2013, 21(2):132‐3

Kis E, Baltás E, Kinyó A, Varga E, Nagy N, Gyulai R, Kemény L, Oláh J. Successful treatment of multiple
basaliomas with bleomycin‐based electrochemotherapy: a case series of three patients with Gorlin‐Goltz
syndrome. Acta Derm Venereol. 2012 92(6):648‐51

B-Cell Lymphoma
Gatti A, Stinco G, Trevisini S, di Meo N, Signoretto D, Leonardo E, Bonin S, Trevisan G. Electrochemotherapy
as a novel treatment for primary cutaneous marginal zone B‐cell lymphomas. Dermatol Ther. 2014,
27(4):244‐7

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Eccrine Porocarcinoma
Marone U, Caracò C, Anniciello AM, Di Monta G, Chiofalo MG, Di Cecilia ML, Mozzillo N. Metastatic eccrine
porocarcinoma: report of a case and review of the literature. World Journal of Surgical Oncology 2011, 9:32

Anal Porocarcinoma
Borgognoni L, Pescitelli L, Urso C, P Brandani P, Sestini S, Chiarugi C, Gelli R, Giannotti V, Gerlini G A rare case
of anal porocarcinoma treated by electrochemotherapy. Future Oncol 2014, 10(15):2429‐34

Xeroderma pigmentosus
Baltás E, Kis E, Nagy N, Sohár N, Varga E, Széll M, Kemény L, Oláh J. Electrochemotherapy for Non‐melanoma
Skin Cancer in a Child with Xeroderma Pigmentosum‐C. Acta Derm Venereol 2017, [Epub ahead of print]

Dermatofibrosarcoma Protuberans
Bonadies A, Elia F, Solivetti FM, Vidiri A, Muscardin L, Bucher S. Electrochemotherapy of a Multirecurrent
Dermatofibrosarcoma Protuberans of the Orbital Margin: A Case Report. Anticancer Res. 2015; 35(11):6121‐
6

Wiater K, Zdzienicki M, Morysinski T, Kosel H, Klimczak A, Obre ̨bski Konrad Ptaszy ́nski M, Rutkowski P:
Effective treatment of recurrent, advanced dermato fibrosarcoma protuberans by electrochemotherapy Eur
J Dermatol 2013, 23(2):260‐1

Angiosarcoma
Guida M, Ruggieri E, Fucci L, Ressa M, D'Aluisio L, Fanelli G, Strippoli S. Image Gallery: A case of cutaneous
giant angiosarcoma treated successfully with electrochemotherapy. Br J Dermatol. 2017 Aug;177(2):e27

Guida M, Campana LG, Curatolo P, Strippoli S, Bonadies A, Grilz G, Cabula C, Rotunno R, Bucher S, Solari N,
Santoriello A, Valpione S, Rossi CR. Local treatment with electrochemotherapy of superficial angiosarcomas:
Efficacy and safety results from a multi‐institutional retrospective study. J Surg Oncol. 2016, 114(2):246‐53

Campana LG, Valpione S, Tosi A, Rastrelli M, Rossi CR, Aliberti C. Angiosarcoma on Lymphedema (Stewart‐
Treves Syndrome): A 12‐Year Follow‐up after Isolated Limb Perfusion, Limb Infusion, and
Electrochemotherapy. J Vasc Interv Radiol. 2016, 27(3):444‐6

Mocerino C, Iannaci G, Sapere P, Luise R, Canonico S, Gambardella A. Multidisciplinary approach to breast
angiosarcoma in an elderly patient: Repeated local relapses and significant objective responses. Int J
Immunopathol Pharmacol. 2016, 29(3):537‐42

Benevento R, Carafa F, Di Nardo D, Pellino G, Letizia A, Taddeo M, Gambardella A, Canonico S, Santoriello A.
Angiosarcoma of the breast: a new therapeutic approach? Int J Surg Case Rep. 2015, 13:30‐2

DESMOID TUMOURS – FIBROMATOSIS
Vitfell‐Rasmussen J, Sandvik RM, Dahlstrøm K, Al‐Farra G, Krarup‐Hansen A, Gehl J. Tumor reduction and
symptom relief after electrochemotherapy in a patient with aggressive fibromatosis ‐ a case report. Acta
Oncol. 2017 Aug 16:1‐4

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                                       VULVAR CARCINOMA
Pellegrino A, Damiani GR, Mangioni C, Strippoli D, Loverro G, Cappello A, Turoli Scd D, Corso S, Tartagni M,
Pezzotta M. Outcomes of Bleomycin‐based electrochemotherapy in patients with repeated loco‐regional
recurrences of vulvar cancer. Acta Oncol 2016, 55(5):619‐24

Perrone AM, Cima S, Pozzati F, Frakulli R, Cammelli S, Tesei M, Gasparre G, Galuppi A, Morganti A G, De iaco
P: Palliative electro‐chemotherapy in elderly patients with vulvar cancer:a phase ii trial. Journal of surgical
oncology, 2015, 112(5):529‐32

Perrone AM, Galuppi A, Cima S et al. Electrochemotherapy can be used as palliative treatment in patients
with repeated loco‐regional recurrence of squamous vulvar cancer: a preliminary study. Gynecol Oncol. 2013;
130(3):550‐3

                                        PROSTATE CANCER
Klein N, Gunther E, Zapf S, El‐Idrissi R, Atta J, Stehling M Prostate cancer infiltrating the bladder sphincter
successfully treated with Electrochemotherapy: a case report.. Clin Case Rep. 2017 Nov 13;5(12):2127‐2132.

                                 VASCULAR MALFORMATIONS
McMorrow L, Shaikh M, Kessell G, Muir T. Bleomycin electrosclerotherapy: new treatment to manage
vascular malformations. Br J Oral Maxillofac Surg. 2017 Oct 18. pii: S0266‐4356(17)30690‐3

                                                                                                            21

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DEEP SEATED TUMOURS
Pancreas
Granata V, Fusco R, Setola SV, Piccirillo M, Leongito M, Palaia R, Granata F, Lastoria S, Izzo F, Petrillo A. Early
radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy. World J
Gastroenterol 2017, 23(26):4767‐4778

Granata V, Fusco R, Piccirillo M, Palaia R, Petrillo A, Izzo F. Electrochemotherapy in locally advanced
pancreatic cancer: Preliminary results. Int J Surg 2015, Int J Surg. 2015, 18:230‐6

Granata V, Fusco R, Piccirillo M, Palaia R, Lastoria S, Petrillo A, Izzo F. Feasibility and Safety of Intraoperative
Electrochemotherapy in locally advanced pancreatic tumor: a preliminary experience. EJI 2014, Volume 12
n. 3

Liver
Gasljevic G, Edhemovic I, Cemazar M, Brecelj E, Gadzijev EM, Music MM, Sersa G. Histopathological findings
in colorectal liver metastases after electrochemotherapy. PLoS One 2017, 12(7):e0180709

Coletti L, Battaglia V, De Simone P, Turturici L, Bartolozzi C, Filipponi F.Safety and feasibility of
electrochemotherapy in patients with unresectable colorectal liver metastases: A pilot study. Int J Surg. 2017
Jun 15;44:26‐32

Tarantino L, Busto G, Nasto A, Fristachi R, Cacace L, Talamo M, Accardo C, Bortone S, Gallo P, Tarantino P,
Nasto RA, Di Minno MN, Ambrosino P. Percutaneous electrochemotherapy in the treatment of portal vein
tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study.
World J Gastroenterol 2017, 23(5):906‐918

Edhemovic I et al. Intraoperative electrochemotherapy of colorectal liver metastases. J Surg Oncol. 2014,
110(3):320‐7

Edhemovic I, Gadzijev EM, Brecelj E et al. Electrochemotherapy: a new technological approach in treatment
of metastases in the liver. Technol Cancer Res Treat. 2011, 10(5):475‐85

Gastric cancer
Campana LG, Scarpa M, Sommariva A, Bonandini E, Valpione S, Sartore L, Rossi CR. Minimally invasive
treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapy. Radiol
Oncol 2013, 47(4): 370‐375

Soft Tissue Sarcomas
Valpione S et al. Phase I/II study of electrochemotherapy with intravenous bleomycin and variable geometry
electric fields for the treatment of deep and large soft tissue tumors. Abstract 1462TiP. Ann of Oncol,
2014,Vol 25, Supplement 4

Campana LG, Bianchi G, Mocellin S, Valpione S, Campanacci L, Brunello A, Donati D, Sieni E, Rossi R.
Electrochemotherapy Treatment of Locally Advancedand Metastatic Soft Tissue Sarcomas: Results of a Non‐
Comparative Phase II Study. World J Surg, 2014, 38(4):813‐22

De Bree R, Tijink BM, van Groeningen CJ, and Leemans CR: Report Electroporation Therapy in Soft Tissue
Sarcoma: A Potentially Effective Novel Treatment Sarcoma 2006, Article ID 85234, Pages 1–

Up-dated January 2018

Lymph Node Metastases
Klein N, Zapf S, Gunther E, Stehling M. Treatment of lymph node metastases from gastric cancer with a
combination of Irreversible Electroporation and Electrochemotherapy: a case report. Clin Case Rep. 2017,
5(8):1389‐1394

Mofid B, Shankayi Z, Novin K, Dehghani S, Shankayi M, Haghighatkhah H, Firoozabadi SM. Effective Treatment
of Cervical Lymph Node Metastasis of Breast Cancer by Low Voltage High‐Frequency Electrochemotherapy.
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