FUTURE HEALTH - SPECIAL REPORT - Julius Baer

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FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE
HEALTH

 SPECIAL REPORT
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
1

                                   FOREWORD
By Dr Damien Ng                    The healthcare system as we know it today can trace its            eating and sleeping habits) and also more efficient ways
Next Generation Research Analyst   origins to the beginning of the 20th century. Based predo-         to manage all aspects of our health, such as the remote
                                   minantly on a sick-care model, the system is essentially one       monitoring of blood pre ssure and the adhe re nce to
                                   that waits until we have fallen ill before it kicks into action.   medication.
                                   In other words, acute care sits at the centre of the conven-
                                   tional approach, at the e xpe nse of pre ve ntion and e arly       Another change will come in the form of genomics. There
                                   intervention. The way medical care is delivered to patients        are still many diseases in the world today that do not have
                                   has change d surprisingly little , de spite the tre me ndous       cures. Medical professionals and scientists are increasingly
                                   progress that has been achieved. The majority of ill people        turning to genomics, artificial intelligence, and big data to
                                   continue to be seen and treated by medical professionals           better predict individuals’ risk of contracting certain types
                                   in brick-and-mortar clinics and hospitals.                         of dise ase s, with the ultimate aim of de riving preve ntive
                                                                                                      measures and tailor-made treatments depending on their
                                   However, healthcare costs have been rapidly rising over the        unique genetic make-up. In the meantime, genomics will
                                   past few decades. This unsustainable increase can be largely       also change the way we treat many of these illnesses when
                                   attributed to the growth of the human tide in the form of          they do develop.
                                   population ageing and a resulting higher incidence of chron-
                                   ic diseases. Together with the advance of rapidly evolving         With so many new developments in the field and a sharp-
                                   digital technologies and shifting consumer preferences for         e ne d focus on the we akne sse s of our curre nt he althcare
                                   convenience and affordability, demand for a more efficient         systems following the outbreak of Covid-19, it is clear that
                                   delivery model is growing ever louder. One of the major            the healthcare system of the future needs to look very dif-
                                   trends presently under way is the transition away from a           ferent from today’s approach. The purpose of this report is
                                   volume-based care model to a value-based one, in which             to explore the ways in which healthcare might change in
                                   patients are more likely to receive the best available care        the coming decades. We start by looking at the situation
                                   from the ir provide rs without ove rpaying. Having an in-          today be fore pre se nting pote ntial route s forward, ne w
                                   depth understanding of the patient through the collection          te chnological and me dical developments, societal shifts,
                                   and exchange of data is key for this transition.                   and the views of industry experts.

                                   The focus of healthcare will gradually shift to a more in-         Healthcaresystems havebeen slow to change, resisting the
                                   dividual approach. Instead of focusing on sickness, the            disruption that has swept through so many other industries.
                                   emphasis will be on the personal experiences and overall           But now could be the time to accelerate an evolution – if
                                   well-being of the consumer. This could come in the form            not a revolution – in the way we think about looking after
                                   of invaluable support for our lifestyle patterns (including        ourselves. So, are you ready for the future of health?
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
CONTENTS

                     4 FUTURE HEALTH
                How to improve modern healthcare

                      10 GOING VIRAL
        The digital world is reinventing medical treatment

                  14 TECH’S HEALTHY FUTURE
    Artificial intelligence is emerging as a major force in health

        18 INNOVATION IN THE TIME OF CORONA
A range of industries have adapted to produce medical equipment

                    20 HOME DISPENSARY
    A series of portraits by photographer Gabriele Galimberti

             34 WHO WANTS TO LIVE FOR EVER?
  A rise in life expectancy is kick-starting the longevity business

              40 A HEALTHCARE REVOLUTION
 The life sciences are coming to the fore in a variety of disciplines

                     46 BINARY CHOICES
The challenge of blending the data revolution with medical practice

       50 BETTER RELATIONSHIPS, BETTER HEALTH
         Why companionship is crucial to a healthy life

           56 IMPORTANT LEGAL INFORMATION

                         58 MASTHEAD
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE
                                                                           5

     HEALTH
               By Dr Damien Ng and Emily Rookwood

     The Covid-19 pandemic has exposed a number of problems
in our healthcare systems that have been bubbling under the surface
for years. The good news is that the crisis will help to supercharge the
              technological progress the industry needs.
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
6                                                                 FUTURE HEALTH

  “We are experiencing a
perfect storm of outdated,
      under-resourced
     infrastructure, and
increased demand that has
   left the failings in our
 global healthcare systems
          exposed.”

Our healthcare systems have never been in sharper focus
than today. Face d with a pande mic on a scale not se e n
since 1918, me dical infrastructure is be ing pushe d to
breaking point – and its dedicated staff with it. The signs
that our systems are not working as well as they could have
been there for decades, but the Covid-19 crisis means it is
no longer possible to ignore them.

We are experiencing a perfect storm of outdated, under-
resourced infrastructure, and increased demand that has
left the failings in our global healthcare systems exposed.
This is de spite global spe nding on he althcare incre asing
at a considerable rate since 1980 because of government
policies and lifestyle changes.

There are several reasons why these costs are on the rise.
First, life expectancies are increasing all over the world. For
the first time in human history, by 2030 the numbe r of
people aged 60 and above will surpass those under the age
of 10. This global demographic change is putting health-
care systems everywhere under extreme stress as they try
to cater to the needs of ageing populations; in the United
States, for example, people over 60 account for nearly half
the total healthcare costs, despite making up just 22 per
cent of patients.

Second, our modern lifestyles have brought about an in-
crease in chronic, non-communicable or ‘lifestyle’ diseases
driven by behaviours such as poor diet, smoking, lack of
exercise, and overconsumption of drugs and alcohol. These
conditions, once conside re d dise ase s of high-income
countries, havespread rapidly around theworld, correlating
strongly with incre asing urbanisation and e conomic de -
velopment. They have replaced infectious diseases as the
le ading global cause s of de ath, and the World He alth
Organization (WHO) estimates that by 2030 total global
de aths from non-communicable dise ase s will re ach 52
million a year, exerting extreme pressure on already over-
worked healthcare systems.

Third, de clining fe rtility rate s have le d to a shortage of
workforce caused by demographic squeeze. This pheno-
me non has the e ffe ct of alte ring the sustainability of
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
FUTURE HEALTH   7
FUTURE HEALTH - SPECIAL REPORT - Julius Baer
8                                                                  FUTURE HEALTH

    “Healthcare has improved vastly in the past 50 years,
       but expectations of what should be provided
      as standard have increased at a far higher rate.”

he althcare syste ms due to the unbalance d supply and        Economist Intelligence Unit reported that this model is
demand of resources in high and middle-income coun-           still in the early stages but countries such as Sweden are
tries. The labour situation is further exacerbated by the     starting to align the ir he althcare with a more out-
wave s of baby-boome r he althcare worke rs who are           come-based system.
beginning to retire, intensifying global competition for
skille d he alth worke rs. According to the WHO the re        The Organisation for Economic Co-operation and De-
will be a worldwide shortfall of around 18 million health     ve lopme nt (OECD) and Europe an Commission both
workers by 2030, with deficits already striking particu-      produced reports on VBHC in 2019, and consulting groups
larly hard in low to middle-income economies.                 and medical companies such as Boston Consulting Group
                                                              (BCG) and Medtronic are highlighting the effectiveness
Lastly, our expectations have changed. Healthcare has         of this new model. One case study by BCG highlighted
improved vastly in the past 50 years, but expectations        reductions of up to 30 per cent in unnecessary inpatient
of what should be provided as standard have increased         stays and up to 74 per cent in the rate of re-operation
at a far higher rate. As our incomes have increased, we       afte r complications in bre ast cance r patie nts afte r the
have come to expect an ever-higher level of healthcare        hospital group Santeon introduced a VBHC approach.
– which obviously comes at a cost.
                                                              Anothe r mode l that could significantly improve avail-
What can be done to improve the situation? Luckily,           ability and efficiency of global healthcare systems, and
the re are many opportunitie s and positive de ve lop-        is currently proving valuablein thebattleagainst corona-
ments on the horizon. One of the first areas to consider      virus, is telemedicine. Switzerland began exploring the
is the model our healthcare systems run on. In the ma-        potential of telemedicine in 2003, and today many he-
jority of countries, healthcare is based on the traditional   alth insurers provide telemedicine services as standard.
fee-for-service reimbursement model, where the incen-
tives are skewed towards performing procedures rather         Tests have also begun of video medicine and smart self-
than making correct diagnoses. However, governments           measurement devices that patients can use in their own
and insurers are increasingly shifting towards an outco-      home s. In China, te le me dicine has be e n promote d
me -base d mode l, such as the value -base d he alth care     by the gove rnme nt since 2014, and Ping An’s Good
(VBHC) model which is based on the research of Har-           Doctor application is now the world’s le ading online
vard Professor Michael Porter. This model compensates         healthcare platform. As well as offering telemedicine, it
he althcare provide rs for the he alth and we ll-be ing of    works with pharmacie s and hospitals as a hub for
their patients, rather than for the services they provide.    medical services. Although Europe has been slow to ad-
In a recent study on the adoption of VBHC globally, the       opt such se rvice s be cause of patie nt and re gulatory
                                                              reticence, the use of telemedicine is increasing: in 2018
                                                              the Europe an Commission e stimate d that the global
                                                              market would grow to EUR 37 billion by 2021, and the
                                                              current crisis is likely to accelerate that growth.

                                                              Which brings us to the broader topic of technology. New
                                                              de ve lopme nts could hold the ke y to many he althcare
                                                              improvements and offer a number of exciting opportuni-
                                                              ties for patients and investors, with digital data helping
                                                              to build robust syste ms that de live r value -base d care .
                                                              While you might assume that developed countries such
                                                              as the US, Germany, or the UK might be leading the way,
                                                              in fact China, India, and Russia are adopting the most
                                                              revolutionary approach when it comes to incorporating
                                                              te chnology into me dicine . The 2019 Philips Future
FUTURE HEALTH                                                                              9

                                    Health Index revealed that 94 per cent of Chinese, 88
                                    per cent of Indian, and 81 per cent of Russian healthcare

                                                                                                       “Switzerland began
                                    professionals use some form of digital health technolo-
                                    gies or mobile health apps, compared with a global aver-
                                    age of 78 per cent. This is compared to 75 per cent in
                                    Brazil, 64 per cent in Germany and only 48 per cent in          exploring the potential of
                                    South Africa (see chart below). Following the Covid-19
                                    crisis, the already booming medtech sector has ramped
                                                                                                   telemedicine in 2003, and
                                    up its developments at a phenomenal pace (read more            today many health insurers
                                                                                                      provide telemedicine
                                    about telemedicine and the medtech boom on page 10).

                                    These technological developments are not the only po-
                                    sitives to look forward to when it comes to future health.        services as standard.”
                                    Longevity science is becoming a multibillion-dollar in-
                                    dustry (se e more on page 34) and the bre akthroughs
                                    coming out of this sector mean that we can live not only
                                    longer, but healthier, fuller lives. A boom in life sciences   On a more pe rsonal note , ne w re se arch showing how
                                    driven by global hubs such as Geneva’s Campus Biotech,         good re lationships can boost our he alth is he lping to
                                    the European Medicines Agency in Amsterdam, and the            drive a social health revolution. One recent report from
                                    Life Sciences Institute in Singapore are exploring myriad      Harvard Medical School says: “Social connections…not
                                    ways to improve our health, from AI support for stroke         only give us pleasure, they also influence our long-term
                                    patients to unlocking new developments in genomics.            health in ways every bit as powerful as adequate sleep, a
                                                                                                   good diet, and not smoking.” Governments, non-profit
                                                                                                   organisations, and communities are coming together to
                                                                                                   boost inte rge ne rational e xchange s, from nurse rie s in
USE OF HEALTHCARE TECHNOLOGIES                                                                     re tire me nt home s to me ntoring sche me s for young
BY HEALTHCARE PROFESSIONALS, 2019                                                                  e ntre pre ne urs run by re tire d CEOs. Efforts to re build
                                                                                                   the sense of community that had all but disappeared in
                                                                                                   many areas have doubled since the enforced isolation of
CHINA                                                                                              the recent pandemic, and have highlighted the medical
                                                                                            94 %   concerns associate d with loneliness. As we look to the
                                                                                                   future of health and healthcare it is clear to see that we,
INDIA                                                                                              the community, have a very large and important role to
                                                                                     88 %          play as we take more responsibility for our wellbeing.

RUSSIA                                                                                             Last, but not le ast, we turn to the me dical profe ssion.
                                                                              81 %                 The one une quivocal stre ngth of he althcare syste ms
                                                                                                   around the world is their staff. The coronavirus outbreak
GLOBAL AVERAGE                                                                                     has pushed the profession to its very limits, but day after
                                                                            78 %                   day, doctors, nurses, porters, and all manner of medical
                                                                                                   workers are risking their lives to help others. While there
BRAZIL                                                                                             are many areas of our systems that need to improve in
                                                                            75 %                   ye ars to come , one thing that we hope re mains a ke y
                                                                                                   feature is a dedicated workforce who really put the care
GERMANY                                                                                            in healthcare.
                                                                    64 %

SOUTH AFRICA                                                                                                    NEXT GENERATION RESEARCH
                                                  48 %
                                                                                                     We are currently experiencing a significant shift in global
                                                                                                     lifestyles. Around the world people are living longer and
   lobal average of healthcare professionals currently using some
  G                                                                                                  the proportion of elderly citizens is increasing year on year.
  form of digital health technologies or mobile health apps                                          This is having a significant effect on our healthcare sys-
                                                                                                     te ms and how we manage our he alth on a daily basis.
   ountry-specific healthcare professionals currently using some
  C                                                                                                  Digital he alth, longe vity, ge nomics, and global he alth
  form of digital health technologies or mobile health apps                                          aware ne ss are all ke y compone nts of the ‘Shifting Life -
                                                                                                     style s’ me gatre nd, one of five me gatre nds curre ntly
                                                                                                     cove re d by Julius Bae r’s Ne xt Ge ne ration Inve stme nt
                                                                                                     approach, which identifies the structural trends that will
                                                                                                     shape the world in the coming years.
GOING
                                                                        11

The Covid-19 pandemic has fast-forwarded the spread of health tech.
Once distinctly different areas – telemedicine, wearables, smartphone
 apps, and the Internet of Things – are converging to revolutionise
                  the way we think about healthcare.

                          By John Arlidge

            VIRAL
12                                                                FUTURE HEALTH

                                                             markably slow to e xploit ne w te chnology. Although
                                                             some countrie s have we ll-e stablishe d te le me dicine
                                                             se rvice s – notably Switze rland and China, whe re Ping
       “The Covid-19 crisis                                  An’s Good Doctor offers more than 300 million users

          is acting as a                                     access to remote consultations as well as a number of
                                                             other medical services including appointments, referrals,

      catalyst for the whole                                 and prescription delivery – the majority still rely almost
                                                             e xclusive ly on the me dical practice approach. That’s
        digital healthcare                                   large ly down to re gulation and conce rns for patie nt
                                                             privacy (see panel). The Covid-19 pandemic has forced
        and telemedicine                                     governments around the world to rethink radically their

            industry.”                                       approach to telemedicine. It is no longer a ‘nice to have’,
                                                             but a ‘need to have’.

                                                             Med-tech firms can scarcely believe their good fortune.
                                                             “The Covid-19 crisis is acting as a catalyst for the whole
                                                             digital healthcare and telemedicine industry,” says Luke
Big shocks change things dramatically overnight. Take        Buhl-Nie lse n, vice pre side nt of busine ss de ve lopme nt
9/11. It transformed security, government surveillance,      and operations at Kry, a leading telemedicine operator
and air travel in a heartbeat. The Covid-19 pandemic is      base d in Swe de n. “Le gislation is moving at bre akne ck
doing the same in health. It has prompted the most rapid     spe e d,” adds Joost Brugge man, co-founde r and chie f
and radical innovation in long-distance , te ch-base d       e xe cutive of Siilo, a Dutch communications tool for
public he althcare the world has e ve r se e n. What te ch   medical professionals. “It usually takes 12-18 months to
e vange lists have spe nt ye ars lobbying for has be e n     convince middle management to approve innovations.
approve d almost ove rnight, cre ating unpre ce de nte d     Right now they’re saying, ‘Give it to us, we’ll figure out
growth and investment opportunities.                         the contracts later.’”

Following the outbreak in the UK, the notoriously slow       Teleme dicine isn’t simply about real-time interactions.
National He alth Se rvice (NHS) chose 11 supplie rs to       It also includes mHealth, which covers the use of emer-
provide video consultations in just 48 hours. More than      ging te chnologies to create a new virtual health space
7,000 doctors’ offices were ordered to conduct as many       for both patients and telemedicine providers. mHealth
video and phone consultations as possible. The propor-       taps into the Internet of Things, such as environmental
tion of NHS healthcare delivered through video calls or      sensors, wearable devices, and mobile apps, for tracking
text messages increased from a meagre 1 per cent to 5        and measuring patients’ health and well-being conditions.
pe r ce nt in a matte r of days, according to the Digital
Health Council, a trade body. Previously, online consul-     This is where the tech giants are trying to get in on the
tations were practically non-existent.                       game. Apple has launched Health Kit, which integrates

Ove r in the US, he alth-privacy le gislation has be e n
amended to allow companies such as Apple, Google, and

                                                                   “Over in the US,
Microsoft to facilitate virtual doctors’ visits through
FaceTime and Skype . Microsoft also plans to launch a
new booking tool for hospitals and doctors, who already
use its Te ams collaboration software to vide o-call pa-
                                                               health-privacy legislation
tients. Hospitals everywhere are testing out Microsoft’s
HoloLens technology to reduce the number of doctors
                                                                  has been amended
exposed to patients with Covid-19. A doctor wearing the           to allow companies
                                                                such as Apple, Google,
augme nte d-re ality goggle s can broadcast image s and
audio from a patie nt e xamination back to colle ague s
outside the room using the Teams app. This minimises
the numbe r of he althcare worke rs who are e xpose d,
                                                                   and Microsoft to
re duce s the amount of prote ctive e quipme nt ne e de d,
and helps patients get better access to specialists, who
                                                               facilitate virtual doctors’
can dial in remotely.                                                 visits through
The te le me dicine re volution has not come a mome nt           FaceTime and Skype.”
too soon. For an industry of its size – global healthcare
is worth an estimated USD 11.9 trillion – it has been re-
GOING VIRAL                                                                         13

                                                                                                       data from wearable devices, including the Apple Watch,
                                MOBILE (PHONE) HEALTH                                                  to enable care teams to spot – or even predict – illness.
                                                                                                       The latest Apple watches have ECG sensors that can alert
Since the coronavirus first began to spread,        if it’s designed with the best intentions,” says   users if they have potentially dangerous irregular heart
smartphones havebecomevital tools in track-         Matt Blaze, a professor at Georgetown Law          rhythms. The Cupertino giant is also rolling out its He-
ing the spread of the disease. Some develop-        who specialises in computer science and pri-
me nts are aime d at he lping individuals to        vacy. “It’s not to say you should never collect    alth Records feature, which is designed to make it easier
ide ntify first symptoms of the illne ss. The       or use data – only that you should be ve ry        to store and use medical data on iPhones. “If you zoom
fe rtility tracke r app Natural Cycle s, for e x-   humble about what assurance s you offe r           out into the future, and look back and ask the question
ample, has added in new vital signs monito-         about privacy.”
ring options. More ge ne ral apps have be e n                                                          ‘What was Apple’s greatest contribution to mankind?’,
updated to monitor and analyse user behavi-         The pote ntial and the pitfalls are ve ry we ll    It will be about health,” says the firm’s CEO, Tim Cook.
our in an attempt to slow the spread of the         illustrated by the controversy around efforts
virus. The se range from apps like We Chat          by Apple and Google to cre ate a Covid-19
and Alipay that now share pe rsonal data            track-and-trace app to he lp to e nsure that       In Seattle, Amazon is working on something inevitably
with the Chinese government, to the use of          the re is no se cond spike in infe ctions. The     dubbed Amazon Prime health, which will have more of
anonymised mobile data to monitor popula-           upside is cle ar. He re are two usually bitte r    a supporting role for healthcare providers. It starts with
tion movements during containment.                  Silicon Valle y rivals coope rating with e ach
                                                    other for the common good.                         Alexa, the firm’s voice-controlled virtual assistant. ‘She’
In the short term, these measures are proving                                                          has begun using US government information to answer
invaluable in the fight to contain the pan-         However, privacy activists and many of the         health queries. Ask her what your symptoms mean and
demic. But there’s a big ‘but’, which Dr Tehilla    firms’ customers say that plans to share with
Shwartz Altshuler, head of the democracy in         gove rnme nts the location and he alth data        she ’ll te ll you. She can e ve n call 911 in an e me rge ncy.
the information age programme at the Israel         the app generates are an unacceptable inva-        Face book is trying to do some thing similar, cre ating a
Democracy Institute, puts well. “We can use         sion of privacy. Apple and Google have come        tool called Preventive Health to encourage users to at-
any technology to fight this horrible disease.      down on the side of privacy, which means the
The question is, who will supervise it and who      app will not be much he lp in combating a          te nd che ck-ups. Use rs can book appointme nts on the
will promise that after this is over, we won’t      future outbreak.                                   Facebook platform and opt to receive personalised pre-
become a surveillance democracy?”
                                                                                                       ventive healthcare recommendations and check-up re-
                                                    Health authorities in some US states, as well
Privacy advocate s worry that the curre nt          as in countries such as Canada and Britain,        minders, including routine health exams, mammograms,
measures already represent too great an in-         urged the two firms to give them more con-         flu shots, and blood pressure screenings.
trusion into our private lives. Hong Kong uses      trol over the kinds of information their apps
phone apps and smart brace le ts that show          can collect. So far, that has not been forth-
where citizens and visitors are. Spreadsheets       coming. Some governments have reacted by           What other trends are emerging? Remote health moni-
and lists ide ntifying pe ople living in or         trying to create their own apps but the prob-      toring technology for hospitals looks set to boom. Many
re turning home from Wuhan, the Chine se            lem is, they don’t work very well on Google        hospitals, notably in the US, are already using it to treat
city whe re the virus first took hold, have         and Apple handsets because they have not
be e n circulating on social me dia in China.       be e n de signe d by Google or Apple . And         Covid-19 patie nts with milde r symptoms in the ir
Singapore ’s he alth ministry has poste d           round and round the debate goes.                   homes. Most are giving patients wearable devices that
information online about e ach coronavirus
                                                                                                       are worn 24/7 to track vital signs. Artificial intelligence
patient, often in great detail.                     The key question is: what’s more important
                                                    in an emergency – privacy or the state? It’s       establishes a baseline reading for each patient and data
Such pe rsonal information can have major           not an acade mic que stion any more . It’s a       from the wearable is transmitted to the hospital, where
implications for an individual’s safe ty and        matter of life and death.                          doctors can quickly spot anomalies, such as a decrease
economic and social well-being.
                                                    “We need to have a discussion on how Silicon       in oxygen levels.
“One of the things we have learned over time        Valley is increasingly taking over the job of a
is that some thing that se e ms anonymous,          nation state,” said one German official. “But      New tech – and the global race to develop a Covid-19
more often than not, is not anonymous, even         we don’t need to have it amid a pandemic.”
                                                                                                       vaccine – will also accelerate clinical trials, a market that
                                                                                                       is worth USD 65 billion according to CB Insights. The
                                                                                                       trial process can take an average of 7.5 years and cost up
                                                                                                       to USD 2 billion per drug, according to the research firm.

                                                                                                       “If you’re a physician working on a clinical trial, your ex-
                                                                                                       pe rie nce is probably no diffe re nt than 20 or 30 ye ars
                                                                                                       ago,” says Gary Hughe s, chie f e xe cutive of Te ckro, a
                                                                                                       software platform that tries to make the process of par-
                                                                                                       ticipating in trials e asie r for doctors and patie nts. “It’s
                                                                                                       still a people and paper process.” Ireland-based Teckro
                                                                                                       has raised USD 25 million from investors, including Peter
                                                                                                       Thiel’s Founders Fund. US biotech firm Amgen is using
                                                                                                       artificial intelligence to improve trial planning so that it
                                                                                                       does not waste time and money setting them up in pla-
                                                                                                       ces where there will be few participants.

                                                                                                       One thing is certain. As telemedicine spreads, we will all
                                                                                                       spend less time in germ-filled waiting rooms. And even
                                                                                                       themost confirmed Ludditewould agreethat is progress.
TECH’S
                                                             15

HEALTHY
FUTURE

                    By Rhymer Rigby

Artificial intelligence was already becoming a key part of
healthcare in the 21st century even before the Covid-19
 pandemic made technological advances more urgent.
16                                                                  FUTURE HEALTH

The coronavirus pandemic means that healthcare is at           Martin Ciupa is an expert in AI. He is CEO of the start-
the top of everyone’s minds. Governments, healthcare           up Me ntal Image ry, CTO of Kimbocare , a blockchain-
providers, and businesses are focusing as never before         enabled tech platform, and has served as chief AI officer
on doing more, faster, and better. This often means using      at Mindmaze, a Swiss unicorn that builds intuitive human
new technologies, one of which is artificial intelligence.     machine interfaces. Recently, he was also elected leader
                                                               of the Ame rican Association of Pre cision Me dicine ’s
When we think of artificial intelligence, we tend to think     Data Science Coronavirus Taskforce. He believes there
of highly inte llige nt robots or compute rs that would        are four main areas where AI will improve medicine: pro-
pass theTuring test – that is, you cannot distinguish them     ductivity, quality, personalisation, and discovery.
from a human. This is sometimes called ‘Strong AI’ and
is de cade s from be coming a re ality. The good ne ws is      The first, productivity, is about making healthcare more
that lesser forms of AI such as machine learning and deep      e fficie nt. “AI can re lie ve pre ssure s on he althcare and
learning are here now and being used in healthcare.            also augment people, allowing them to do more work in
                                                               a given day,” says Ciupa. This is a potentially huge de-
In fact, AI re cognise d the coronavirus e pide mic ve ry      velopment. To take the first statement, according to the
early on. The AI platform BlueDot spotted and flagged          ‘Harvard Business Review’, labour is the single biggest
a cluster of ‘unusual pneumonia’ cases on 30 December          cost in US healthcare. Moreover, productivity has been
last ye ar, ne arly a we e k be fore any official announce -   de clining for de cade s and it is e stimate d that of the
ments weremade. BlueDot takes its data from thousands          USD 3 trillion spent annually on healthcare in the US, a
of sources, ranging from airline ticketing to public health    third is wasted.
announce me nts. Inde e d, this is one place whe re AI
come s to the fore – the ability to take unimaginable          This wastage is often most visible in areas such as poor
amounts of data in different formats.                          be d allocation and othe r administrative ine fficie ncie s.
                                                               But it also manife sts itse lf in having e xpe nsive pe ople
                                                               such as doctors doing administrative or mundane medi-
                                                               cal tasks, the kind of things AI excels at. Use it to replace

      “Martin Ciupa believes                                   people and not only do you save money, but also doctors
                                                               can spend more time with patients.
     there are four main areas
                                                               When it comes to productivity, it is worth remembering
       where AI will improve                                   that healthcare is very different from other industries. In

      medicine: productivity,                                  he althcare syste ms across the world, de mand consis-
                                                               te ntly outstrips supply (or affordable supply). Thus, if

      quality, personalisation,                                you can provide more service for the same expenditure
                                                               you are likely to have a healthier population, not greater
          and discovery.”                                      numbers of unemployed doctors or nurses. People will
                                                               ‘consume’ more healthcare and the world will be a better,
                                                               fitter place for it.

In the US, a project involving organisations such as Micro-    The second area is quality. “An example of this is examin-
soft Research, the National Library of Medicine, and the       ing X-rays and MRI scans,” says Ciupa. “Deep learning
Allen Institute for AI is under way to mine useful infor-      is really good at looking at medical images and already
mation and gain insights from around 30,000 research           performs at similar radiological levels to human experts.”
papers on the novel coronavirus and its wider family.
                                                               In late 2018, Stanford University announced it had de-
Othe r AI applications are also be ing mobilise d in the       veloped a new algorithm that could read chest X-rays as
fight against the virus. Examples include facial recogni-      well as radiologists. Crucially, this algorithm was reading
tion syste ms that can de te ct the symptoms of fe ve r,       them for 14 different pathologies, not just one, represen-
sophisticate d monitoring e quipme nt, AI chatbots for         ting huge potential efficiency gains. Te chnology could
online consultations, and software for pandemic model-         e ve n le ad to digital consultations; me d-te ch company
ling. Israe li company Nanox has de ve lope d an e asily       Babylon has claime d its chatbots can alre ady surpass
portable digital X-ray syste m that conne cts to cloud-        doctors in terms of the accuracy of diagnosis.
based AI to diagnose infections and help prevent future
outbreaks.                                                     The benefits of automating routine tasks such as initial
                                                               consultations range from vastly reduced waiting times in
But what about healthcare more generally? What possi-          the developed world to access to medical services for the
bilitie s doe s AI hold for a he althie r world once we ge t   first time in the developing world. Huge strides are al-
through the current crisis?                                    ready being made with telemedicine in Africa.
TECH’S HEALTHY FUTURE                                                                     17

                   “AI can relieve pressures on healthcare
                  and also augment people, allowing them
                      to do more work in a given day.”

The use of AI to dige st huge amounts of data could             treating it.” Nor is it just the obvious stuff. AI might mean
result in other discoveries too. “There’s a trial at London’s   tailore d, virtual re ality physiothe rapy, for e xample .
Moorfields Eye Hospital where AI is being used to look          Again, this would be likely to deliver better, faster, and
at thousands of e ye scans,” says Kim Nilsson, CEO of           cheaper results.
Pivigo, a data sciencemarketplaceand training company.
The scans are compare d and cross-re fe re nce d with an        The last and pe rhaps most e xciting are a whe re AI will
individual’s medical history to see if they can show that       be a game -change r is the discove ry of ne w drugs.
patie nts are at risk of othe r conditions. “For instance ,     “De ve loping a ne w drug can cost USD 1 billion,” says
does your scan indicate you are at risk of diabetes?”           Nilsson. “AI could cut that in half.” It can do this in all
                                                                sorts of ways. The obvious ones, perhaps, are sequencing
Nilsson adds that the use of AI to analyse and interpret        the DNA or RNA of new viruse s and mapping the m to
huge amounts of data will become ever more important            suggest which treatments are likely to be most effective.
as the Inte rne t of Things take s off and smart de vice s      Others include screening and monitoring participants in
proliferate. With wearables that constantly stream infor-       medical trials.
mation on your health, people could be monitored in real
time and AI could pick up problems such as heart con-           One of the most promising possibilities is re purposing
ditions while they are minor and easily treatable – and         existing drugs to treat new conditions. AI’s ability to find
even before any conditions develop.                             needles in haystacks of data is key here. Existing drugs
                                                                do not ne e d the same sort of clinical trials; the ir side
While AI can discern patterns in the data of millions of        effects areknown, they arealready FDA or EMA-approv-
patie nts, it can also make tre atme nt on an individual        ed, and they are cheaper and more efficient. “You might
basis much more personal. This will result in better out-       look at an existing drug for arthritis that also has possi-
comes and lower costs because people receive treatment          bilities for treating high blood pressure,” says Nilsson.
tailore d spe cifically to the m. In a re ce nt note , Giulia
Besana, an analyst at IDC Health Insights, wrote: “Euro-        Ultimately, the future that AI and associated technolo-
pean healthcare providers are betting on AI to support          gie s hold for me dicine is one of vastly more data and
greater personalisation of healthcare services.”                vastly more use ful knowle dge gle ane d from that data.
                                                                “You will go about your daily business while wearing your
What does this mean in practice? “If you think of current       watch and your smartphone,” says Ciupa. “Thedata from
healthcare as Healthcare 3.0, it’s set up a bit like one of     these devices will allow AI to detect problems and rec-
Henry Ford’s factories,” says Ciupa. “You come into hos-        omme nd pe rsonalise d tre atme nts be fore you know
pital and get on a production line. You are given a stan-       anything is wrong.”
dard battery of tests until the hospital discovers what is
wrong with you. However, AI will result in Healthcare 4.0.      You will suffer from fewer illnesses and you will recover
This, like Industry 4.0 more generally, will mean greater       quicke r. Inde e d, some , such as Babylon’s Dr Ali Parsa,
automation, cyberphysical systems, data exchange and            have predicted that AI and associated technologies will
proliferation of AI.”                                           be so revolutionary for healthcare that in a decade or so
                                                                the issue of funding will no longer be a problem.
For patients this will deliver a far more tailored, person-
alised service from the word go. The business of health-        But all this is some way in the future . Right now, all
care will become more efficient, and far more factors will      e ne rgie s are focuse d on the coronavirus. And he re , AI
betaken into account during consultation and treatment.         doe s have an important role to play. It won’t stop this
“For e xample , a pe rson who has Alzhe ime r’s may also        pandemic but, by crunching vast amounts of data, it may
have depression and anxiety,” says Ciupa. “At the mo-           spe e d up the race to find a vaccine and he lp pre dict
me nt the se ofte n cannot be take n into account whe n         future outbreaks.
INNOVATION
18                                                               FUTURE HEALTH

        IN THE TIME
       OF CORONA

                 COMPANY Nike, US                              COMPANY Sharp, Japan                          COMPANY Beiersdorf, Germany
        PRINCIPAL OUTPUT Sporting goods              PRINCIPAL OUTPUT Electronics manufacturer     PRINCIPAL OUTPUT Skincare product manufacture
               and clothing manufacturer                PIVOT Pivoted a TV plant manufacturing          PIVOT Simultaneously producing medical
     PIVOT Repurposing existing elements used to        LCD display panels to produce face masks      disinfectants alongside skincare products from
       produce Nike trainers to make face shields               for Japanese population                    brands including Nivea and La Prairie
      PRODUCTION Distributed across Oregon,            PRODUCTION From 150,000-500,000                PRODUCTION 500 tonnes to be distributed
         Massachusetts, Tennessee, Missouri,                 a day as production ramps up                  across Europe from production sites in
      Ohio, as well as Belgium, Netherlands, China                                                                  Germany and Spain

                   FACE SHIELD                                      FACE MASK                                        SANITISER
19

Need is one of the most powerful drivers when it comes to innovation. The urgent need
   for medical equipment and supplies caused by the Covid-19 pandemic has led to
 an unprecedented response not only from the medical sector, but also from myriad
    other industries. From hospitality and motoring to cosmetics and luxury fashion,
  businesses have come together to bridge the gap between supply and demand in
     a remarkable show of global solidarity. While hotels and restaurants have been
supplying accommodation and meals for medical staff, industries with manufacturing
   capabilities have transformed their production lines to make medical equipment,
  such as ventilators and CPAP (continuous positive airway pressure) machines, and
    PPE (personal protective equipment), including face shields, masks, and gloves.
  Here we illustrate some of the innovative pivots that companies around the world
            have made in their drive to contribute towards the relief efforts.

           COMPANY Prada, Italy                        COMPANY LVMH, France                                   COMPANY JCB, UK
        PRINCIPAL OUTPUT Luxury           PRINCIPAL OUTPUT Luxury goods conglomerate             PRINCIPAL OUTPUT Manufacturing equipment
            fashion manufacturer         PIVOT Perfume production lines of Dior and Guerlain          including earth excavators and diggers
       PIVOT Diverted production to              switched to producing hand sanitiser in           PIVOT Producing steel casing for emergency
        medical overalls and masks for        72 hours; jeweller Bvlgari turned its factory in       CoVent ventilators designed with Dyson
          hospitals across Tuscany           Lodi (Italy) from producing perfumes and hotel       PRODUCTION 10,000 initial order from UK
      PRODUCTION 80,000 medical                      amenities to hand sanitiser gels                government, now no longer required due
      overalls, 110,000 masks produced   PRODUCTION 12 tonnes of sanitiser to 39 hospitals                   to specification changes
           at the factory in Perugia      in France, plus expansive global response; hundreds
                                             of thousands of sanitiser gel bottles distributed
                                                             in Italy and the UK

          MEDICAL OVERALLS                                   SANITISER                                     COVENT VENTILATOR
HOME
                                                                                                                                                          21

DISPENSARY
    By 2023, it is estimated that the global pharmaceutical market will
   exceed USD 1.5 trillion, with key growth coming from ‘pharmerging’
   markets. But medicines are not just mere commodities: they offer an
     insight into differing behaviours and cultures around the world.

                                             Photos by Gabriele Galimberti

By 2023, it is estimated that the global pharmaceutical market will exceed       style trends among the global population. As a much broader approach
USD 1.5 trillion, with key growth coming from ‘pharmerging’ markets in-          to health – one that encompasses our diet, fitness, lifestyle, and overall
cluding the BRIC countries, Mexico, Turkey, Thailand, and South Africa.          wellness – is increasingly adopte d, the use of immune boosting supple -
The highe r-income countrie s, howe ve r, maintain the highe st pe r capita      ments as well as integrated traditional and complementary medicine is on
consumption of pharmaceuticals, and as new treatments become available           the rise.
this continues to rise: global medicine use has increased by 3 per cent a year
since 2014, and by 2019 global defined daily doses stood at 1.822 billion.       Photographer Gabriele Galimberti’s ‘Home Pharma’ series offers intimate
                                                                                 portraits of the personal and cultural differences in medicine consumption
Me dicine s are not just commoditie s; the y offe r an insight into diffe ring   across the globe, while reinforcing the fact that whatever your approach to
behaviours and cultures around the world and speak to wellness and life-         health and lifestyle, medicines are a part of everyone’s daily life.
22                                                  FUTURE HEALTH

         Arnaud Brunel and his wife Candelita in their house in Lausanne, Switzerland. Arnaud is CEO of Tectona.
     He is also an avid collector of photography and supporter of various photographic institutions. In the photograph,
            some of the works he owns are visible, including by Richard Avedon, Andres Serrano, and Vik Muniz.
HOME DISPENSARY                                                                      23

Marco Segato, 47, Vittoria Ruzzi, 30, Gherardo, 4, and Pietro, 1, are Italians but live in a high-end condo in Miami, USA. Marco is an agent
    for luxury yachts built in Italy, while Vittoria is an architect. They travel, often to exotic destinations, both for pleasure and work.
     Many of the medicines in their house come from Italy where, in contrast to the USA, there is a single-payer healthcare system.
24                                                                      FUTURE HEALTH

          Susan Fisher, 35, is a yoga teacher and has a popular yoga studio just under her apartment in a trendy area of Zurich, Switzerland. She does not
         use allopathic medicines, only homeopathic remedies. She also uses Ayahuasca wine, which can be seen in the red jar at the centre of the photo.
     Ayahuasca is a traditional brew of leaves and roots consumed as a spiritual medicine in ceremonies among the indigenous peoples of the Amazon basin.
       Its effects include hallucinations, spiritual revelations, and vomiting, considered to be an essential part of the experience as it represents the release
                                      of negative energy and emotions. It has become increasingly popular among Westerners.
HOME DISPENSARY                                                                 25

Henri Caillet, 92, getting some exercise in his home in Bretigny, Switzerland. Henri was a manager in a factory in the German part
  of Switzerland and a very keen player of pétanque. He is in very good health and does not have many medicines in his home.
                         The only one he regularly uses is syrup for catarrh, since he used to smoke heavily.
27

  Yasumasa, 70, and his wife Nobuko, 66, in their bedroom. They live in the Honatsugi district of Tokyo, Japan. They are both retired
and have two sons, who visit with their families at weekends. Yasumasa has a heart condition, for which he takes multiple daily medicines
         (seen in the small transparent sachets in the photo). Nobuko takes calcium for osteoporosis and aspirin for her heart.
28

       Noorjaha Sagri, 56, her husband Abbas Ali Sagri, 67, and, from left to right, their children Faisal, 24, Heena, 17 and Rafiq, 22. They live in a one-room flat
     in the Dharavi slum of Mumbai, India. At night they pull out a mattress and all sleep in one room. The parents do not work, while the children do sporadically
                      and are the only source of income for the family. Abbas has suffered a stroke, so most of the medicines visible are for his use.
30                                                              FUTURE HEALTH

        Arunas Andriejauskas, 53, and his wife Aliona Andriejauskaite, 52, in their home in Preila, Lithuania. Arunas is an engineer and Aliona
        teaches science. They deeply believe in the curative powers of nature and do not use industrial pharmaceuticals. Instead they produce
     their own remedies, foraging in the woods around their house for herbs, mushrooms, and berries and harvesting from their vegetable garden
                and honey production. They have a large selection of essential oils that have specific applications for different ailments.
HOME DISPENSARY                                                             31

Isidro Flores Gonzales, 48, and his son Adrian Flores Mendoza, 25, in their house in Xochimilco, a borough of Mexico City.
     Isidro is a biologist and founder of the conservation group Santuario del Ajolote, which tries to protect the axolotl,
                                    a rare kind of salamander that lives in the nearby lakes.
32                                                     FUTURE HEALTH

        Paola Agnelli, 62, and Roberto Galimberti, 68, with their cat Nina in their apartment in Castiglion Fiorentino, Italy.
      They are both retired: Paola was a schoolteacher and Roberto a surveyor. Roberto suffers from a weak heart, for which
     he takes enalapril and Xarelto every day, while Paola has had three operations to remove cancers and has to take Femara
        (an anti-tumour drug) daily and Dibase twice a month, to counteract the negative effects of the anti-tumour drug.
WHO WANTS
34

       TO LIVE
      FOR EVER?

                        By Rhymer Rigby

     Advances in technology mean life expectancy is growing
      rapidly – but are we all prepared for how living to 150
               will transform and challenge society?
36                                                                  FUTURE HEALTH

          “How long would you like to live if you were
        healthy – if you had the anatomy and physiology
                      of when you were 25?”

When people talk about longevity, they tend to focus on        we re crazy – that it just doe sn’t happe n in biote ch for
the exciting scientific and social side of things – technol-   early-stage assets.”
ogie s that e nable pe ople to live to 150 or e ve n 250.
Multiple careers. Families with eight living generations.      This feeling of change in the sector has been helped by
But what about the business side of things? What is it like    well-known individuals ranging from serial entrepreneur
to be working in the longe vity fie ld, and what are the       Peter Thiel to Amazon CEO Jeff Bezos either investing
prospects for longevity businesses?                            in longevity-related businesses or making significant do-
                                                               nations to research foundations. As Bailey says, “This is
Juvenescence is a global biotech company that develops         going to come as a big surprise, but ultra-high-net-worth
therapies to treat diseases of ageing and increase human       individuals want to live longer – who’d have thought it?”
longevity. Dr Greg Bailey, its CEO and co-founder, says
he sees the commercial opportunities as being largely in       Juvenescence’s own investors include everyone from fam-
improving old age.                                             ily offices to financial institutions; there are roughly 120
                                                               in total. Although a doctor by training, Bailey has a long
“The goal of our company is to modify ageing,” he says.        track record in the industry. This is his fourth senior bio-
“We are le ss conce rne d about incre asing your life span     te ch company. Othe rs include Me divation, which was
than we are about improving your he alth.” The point,          bought by Pfizer for USD 14 billion, and Biohaven, which
he continue s, is to incre ase your ‘he althspan’ – your       trade s on the Ne w York Stock Exchange and curre ntly
healthy lifespan. The average lifespan in the developed        has a market capitalisation of more than USD 4 billion.
world has increased enormously in recent decades, but
the ave rage he althy life span has not. In fact, in many      The Bank of America has said it expects longevity to be
countries it is decreasing. We live longer, but with more      a USD 610 billion industry by 2025. In a 2019 state -
years of ill health.                                           ment, two of its analysts wrote, “Medical knowledge will
                                                               double e ve ry 73 days by 2020 vs. e ve ry 3.5 (ye ars) in
“Nobody wants to live to 120 if for the last 60 years of       2010, and ge nomic se que ncing costs have falle n
that you are in a wheelchair or have Alzheimer’s,” Bailey      99.999 pe r ce nt since 2003. This has e nable d a ne w
says. “So the question we’re asking at Juvenescence is:        frontie r in pre cision me dicine to furthe r e xte nd life
how do you live healthily? How long would you like to live     expectancy, heralding a ‘techmanity’ [technology meets
if you were healthy – if you had the anatomy and physio-       humanity] revolution.”
logy of when you were 25?” Huge leaps in longevity tech-
nologie s are happe ning now, he adds. We are le arning        The pre dictions for what an e xte nde d life span might
about the genes that control ageing and how to manipu-         entail vary hugely. At the moment, the world’s longest-
late them, we are learning to regenerate tissue, and we        live d outlie rs max out at just ove r 120. But change is
are developing better drugs. “This is going to take place      coming. Profe ssor Sarah Harpe r of Oxford Unive rsity
so much faster than people think.” We are, he believes,        recently said that a baby born today would be looking at
at an inflection point.                                        an expected lifespan of 104 years.

He means this in a business sense too. “For the first time,    We are also se e ing incre asing gains in life span, the
pe ople are re cognising that this is re al and capital is     coronavirus notwithstanding. Between 2000 and 2016,
beginning to flow into this sector – and the more money        according to the World He alth Organization, global
that flows into the sector the faster the technologies are     e xpe ctancy rose by 5.5 ye ars – the gre ate st incre ase
going to develop. If anyone had told me that we would          since the 1960s. This ope ns up a tantalising prospe ct;
raise USD 168 million in two years, I would have said you      that the rate of medical advance means that if you can
WHO WANTS TO LIVE FOR EVER?                                                                                 37

make it to, say, 2050, you may be able to live more or less              proper placebo-controlled clinical trials. “Our reputation
indefinitely. The biomedical theorist Aubrey de Grey has                 is everything. We would pull a product if we found out
suggested that some people already born will live for up                 the science wasn’t strong, even if it was making GBP 100
to 1,000 years.                                                          million a year.”

“I disagree with Aubrey,” says Bailey. “But I think 120 to               But what about the social implications of all this ageing?
150 is on the cards for most people and that means we                    There’s a perception – perhaps aided by the interest of
have to sort out things like Alzheimer’s and Parkinson’s                 Silicon Valley billionaires in this area – that longevity is a
and arthritis or it’s not going to be viable . Right now,                luxury good. In fact, this is unlikely to be the choice. “My
we’re working on the prevention of Alzheimer’s because                   first company madea prostatecancer drug, and 240,000
I think that’s more likely to be successful than treatment.”             men in Europe will get prostate cancer – but 400 million
Alzhe ime r’s, he adds, is a difficult one be cause it has               Europeans are going to age, so it’s a completely different
multiple causes, so a cure or treatment for arthritis is likely          proposition,” says Baile y. “If the drug can be made for
to be found earlier.                                                     5 pence, I don’t need to charge more than a pound becau-
                                                                         se the patient population who can afford a pound a day
Juve ne sce nce , howe ve r, is not just about the type of               is probably a billion pe ople globally, which of course
medicine found in hospitals. “Juvenescence is pursuing                   would translate to USD 365 billion per year, thus the Bank
standard pharmace utical products and IP-prote cte d                     of America number. But it will not be one drug; it will be
supple me nts or me dical foods base d on rigorous sci-                  a cocktail, probably unique to that patient or person.”
ence,” explains Bailey. “We have a division that is creating
young stem cells frozen in a simple syringe that could be                The sheer breadth of what ageing and longevity cover is
used for someone who damages their lungs or for spinal                   ofte n surprising too. “We lice nse d a ne w te chnology
cord regeneration, but we will also sell products that are               out of a university in January and it’s based on the fact
validated scientifically to protect your brain or your heart,            that if you’re under the age of seven and you lose the tip
for example, directly to consumers.” However, he adds,                   of your finge r, in a significant numbe r of case s it will
the science behind these supplements will be based on                    spontane ously re grow,” says Baile y. “I think in pe rhaps

                                                        ALTERED INTRACELLULAR
                                                            COMMUNICATION
                                                     With age, cells increasingly transmit
                                                    self-preserving signals that contribute
                                                      to decline in tissue health. This is
      STEM CELL EXHAUSTION                                                                                GENOMIC INSTABILITY
                                                     related to diseases such as diabetes
      Grey hair is an example of an                                                                      One of the principal signs of
                                                             and atherosclerosis.
  outward sign of ageing caused by an                                                                genomic instability is compromised
   inward one; stem cells that have lost                                                             DNA repair. Chromosomes become
  their ability to divide or replace those                                                             less stable with age, but are also
  that have migrated, differentiated, or                                                              more affected by environmental
   died. This is also linked to frailty and                                                          factors such as physiological stress
       weakened immune systems.                                                                         or disrupted circadian rhythms.

       CELLULAR SENESCENCE                                                                                TELOMERE ATTRITION
    As cells age, they lose the ability to                                                                During the ageing process,
    divide and grow, due to damage or                                                                   telomeres, sections of DNA at
      lack of necessary components.                                                                      the end of chromosomes, are
   They eventually stop completely in a
   phenomenon called senescence that                        AGEING AS                                   progressively shortened by the
                                                                                                      process of cell division and become
   increases the risk of carcinogenesis.                    A DISEASE                                          prone to damage.

           MITOCHONDRIAL                                                                                EPIGENETIC ALTERATIONS
             DYSFUNCTION                                                                              Over time, changes in the genome
  Cells lose mitochondrial integrity due                                                              of a cell occur through exposure to
   to age and oxidative stress. This is a                                                             environmental factors, increasing
    characteristic of diseases such as                                                                     chromosome fragility and
      Huntington’s and Parkinson’s.                                                                  transcriptional noise in ageing cells.

                                         DEREGULATED                                     LOSS OF
                                      NUTRIENT SENSING                               PROTEOSTASIS
                                 The by-products of a functioning              The process that regulates cell
                                 metabolism damage cells, causing           proteins declines due to exposure to
                                them to age faster. These molecules        environmental stresses and can result
                                 can affect our nutritional balance         in Alzheimer’s, cancer, and diabetes.
                                  and lead to age-related obesity.
38                                                              FUTURE HEALTH

     “We are less concerned
        about increasing
      your lifespan than we
      are about improving
          your health.”

10 years’ time, we will have unravelled this ability to turn
on the switch in the body that allows you to regrow a limb
or an organ.”

The possibility this holds out is of people over 100 living
as if they are much younger because their worn-out parts,
such as kidneys, have been replaced. These parts will also
be ‘young’ – you will be getting a one-day-old kidney even
if you are 80. Humans, like cars, would be able to run in-
definitely as long as spares were available.

As for the wider business implications of millions of healthy
ce nte narians, the se are almost limitle ss. It will affe ct
e ve rything from human re production and pe nsions to
property and food production. “The key takeaway from
this is that what we have all thought of as crazy science
fiction is happe ning now: scie nce fiction has be come
today’s scie nce ,” says Bailey. “It’s going to have a huge
impact on a varie ty of industrie s, pe ople ’s live s, and
gove rnme nt policy – all in all it’s going to be ve ry dis-
ruptive but equally incredibly exciting.”
WHO WANTS TO LIVE FOR EVER?   39
40   FUTURE HEALTH
A
                                                                                                                                                 41

     HEALTHCARE
     REVOLUTION
Technological advancements are having a profound effect in the world
of life sciences, with new therapies across a range of areas promising to
                      change healthcare dramatically.

                                                     By Janet Anderson

Life scie nce s are re volutionising he althcare by providing solutions    Clément, President of BioAlps, an association that supports life scien-
whe re traditional me dicine is failing or simply too e xpe nsive . From   ces in Switzerland, has been directly involved in the rapid emergence
ne uroscie nce , biote ch, and me dte ch to smart digital solutions,       of the se ctor. “Whe n you think that our unde rstanding of the brain
life sciences cover a burgeoning new field with enormous potential. Take   today is at about the same level as our knowledge of the heart 40 years
ne uroscie nce s as an e xample . Ne w the rapie s for age -re late d      ago, this can only be the beginning of the revolution,” he says. To find
brain diseases and conditions such as Alzheimer’s and Parkinson’s are      out more, over the next four pages we explore one of the world’s leading
alre ady e nte ring the marke t and re volutionising tre atme nt. Claude   life sciences hubs...
42                                                           FUTURE HEALTH

        LIFE SCIENCES IN
     WESTERN SWITZERLAND:
      MORE THAN THE SUM
          OF ITS PARTS
                                                     BASEL
                                                                         ZURICH

                                             BERNE
                                                                                           CHUR

                       LAUSANNE

                                  MONTREUX

              GENEVA

                                                                                  LUGANO

       Switzerland has emerged as the European leader in life sciences in terms of
     scientific research output, biomedical patent activity, presence of biomedically
      focused venture capitalists, and availability of human capital. Since the early
     2000s, Western Switzerland has witnessed the convergence of biotechnology
      and medical technologies to form what is today known as the Health Valley.

     Thomas Bohn, Executive Director of the Greater Geneva Berne area (GGBa),
       the official promotion agency for Western Switzerland, has been closely
         involved. “This initiative was spearheaded and promoted by political
       authorities and industry support organisations, as well as academics and
     philanthropists,” he says. “Their vision and dedication have enabled Western
      Switzerland’s life sciences ecosystem to become one of the most advanced
                 and most diversified in the world in just over 15 years.”
A HEALTHCARE REVOLUTION                                     43

“At BioAlps we try to understand the globality of health and anticipate what is coming
next and prepare to be leaders in it. The future will be less about new drugs and more
  about digital solutions, smart devices in the shape of wearables, mass data-driven
      understanding of trends, the development of tailored treatments, and the
     prevention of diseases on a global scale. The life sciences have the potential
                   to deliver health improvements across the globe.”
                                 Claude Clément — President, BioAlps

                                        1,000
                               INDUSTRY MEMBERS
                                    varying in size
                               from one-man start-ups
                                   to multinational
                                    conglomerates

                                     BIOALPS
                               BioAlps brings together
                             start-ups, universities, and
                              industry through regular
                                 networking events.
              SECTORS                                                           100
                Biotech                                                  INSTITUTIONS
             Digital health                                                 including:
               Medtech                                                 Research foundations
           Science suppliers                                               Universities
              Incubators                                                 Technical schools
           Investment funds                                               Nursing schools
               Nutrition                                                       EPFL
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