Hannover Medical School - Hannover Biomedical Research School - Medizinische Hochschule Hannover

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Hannover Medical School - Hannover Biomedical Research School - Medizinische Hochschule Hannover
Hannover Medical School
 Hannover Biomedical Research School

                      Curriculum

          MD/PhD Program “Molecular Medicine”

PhD Programs “Infection Biology” and “DEWIN”: Dynamics of
               Host-Pathogen Interactions

          PhD Program “Regenerative Sciences”

            PhD Program “Auditory Sciences”

               PhD Program “Epidemiology”

            Winter and Summer Semester 2018 / 2019
Hannover Medical School - Hannover Biomedical Research School - Medizinische Hochschule Hannover
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        Hannover Medical School
 Hannover Biomedical Research School

                      Curriculum

          MD/PhD Program “Molecular Medicine”

PhD Programs “Infection Biology” and “DEWIN”: Dynamics of
               Host-Pathogen Interactions

          PhD Program “Regenerative Sciences”

            PhD Program “Auditory Sciences”

               PhD Program “Epidemiology”

            Winter and Summer Semester 2018 / 2019

               www.mh-hannover.de/hbrs.html
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PhD Curriculum                          Hannover Medical School

                               Academic Year

Winter Semester 2018 / 2019

Start:                                           October 8th, 2018
                                                 (Opening ceremony October, 15th)

End:                                             February 25th, 2019

MD/PhD “Molecular Medicine” intermediate examination:         from January 14th to
February 25th, 2019 (students organise the date)
PhD “Infection Biology” / “DEWIN” intermediate examination:   March 27th, 2019
PhD “Regenerative Sciences” intermediate examination:         by March 30th, 2019
PhD “Epidemiology” and PhD “Auditory Sciences” intermediate examination: To be
decided on an individual basis, depending also on status of PhD thesis

Summer Semester 2019

Start:                                           April 1st, 2019

End:                                             July 12th, 2019
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         Organisation of Hannover Biomedical Research School

Members of the International Advisory Board:
Prof. Dr. Nathalie Cartier (INSERM U986 MIRCen CEA, Fontenay aux Roses, France)
Prof. Dr. Michael Carroll (Harvard Medical School, Children’s Hospital, Boston, USA)
Prof. Dr. Joachim R. Kalden (University of Erlangen, Germany)
Prof. Dr. Steve Keyse (University of Dundee, UK)
Prof. Dr. Hans-Gustaf Ljunggren (Karolinska Institute, Stockholm, Sweden)
Prof. Dr. Seppo Meri (University of Helsinki, Finland)
Prof. Dr. Stanislas Pol (Département des maladies du foie, Cochin, University Hospital Paris, France)
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Dean of the HBRS and chairman of MD/PhD program “Molecular Medicine”:
     Prof. Dr. Reinhold E. Schmidt                                        Tel 0049-511-532-6656
     Clinical Immunology and Rheumatology                                 Fax 0049-511-532-9067
     Medizinische Hochschule Hannover
     Carl-Neuberg-Str. 1
     D-30625 Hannover
     E-mail: Immunologie@mh-hannover.de

Coordination of HBRS and MD/PhD program “Molecular Medicine”:
   Dr. Susanne Kruse and Birgit Müller
   HBRS Office of the MHH                        Tel 0049-511-532-6011
   Präsidialamt, OE 9117                         Fax 0049-511-532-2611
   Carl-Neuberg-Str. 1
   D-30625 Hannover
   E-mail: hbrs@mh-hannover.de;
   kruse.susanne@mh-hannover.de; mueller.birgit@mh-hannover.de
   Web: www.mh-hannover.de/md-phd.html

-------------------------------------------------------------------------------------

Chairman of PhD programs “Infection Biology” and “DEWIN”:
   Prof. Dr. Reinhold Förster                    Tel 0049-511-532-9721
   Institute of Immunology                       Fax 0049-511-532-9722
   Medizinische Hochschule Hannover
   Carl-Neuberg-Str. 1
   D-30625 Hannover
   E-mail: foerster.reinhold@mh-hannover.de

Coordination of PhD programs “Infection Biology” and “DEWIN”:
   Dr. Sabine Johann and Simone Zimmer            Tel 0049-511-532-9742
   Zentrum für Infektionsbiologie - ZIB           Fax 0049-511-532-9722
   Institut für Immunologie, OE 5240
   Medizinische Hochschule Hannover
   Carl-Neuberg-Str. 1
   D-30625 Hannover
   E-mail: zib@mh-hannover.de
   Web: www.mh-hannover.de/zib.html
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Chairman of PhD program “Regenerative Sciences”:
   Prof. Dr. Ulrich Martin                     Tel 0049-511-532-8821
   LEBAO                                       Fax 0049-511-532-8819
   Medizinische Hochschule Hannover
   Carl-Neuberg-Str. 1
   D-30625 Hannover
   E-mail: martin.ulrich@mh-hannover.de
Coordination of PhD program “Regenerative Sciences”:
   Dr. Daniela Pelz                               Tel 0049-511-532-5206
   Mariam Kujenya                                 Tel 0049-511-532-5202
   “REBIRTH“, OE 8880                             Fax 0049-511-532-5205
   Medizinische Hochschule Hannover
   Carl-Neuberg-Str. 1
   D-30625 Hannover
   E-mail: phd-regsci@mh-hannover.de
   Web: www.rebirth-hannover.de/en/phd-program.html

-------------------------------------------------------------------------------------

Chairman of PhD program “Auditory Sciences”:
   Prof. Dr. Andrej Kral                                                  Tel 0049-511-532-7272
   Institut für Audio-Neurotechnologie (VIANNA)                           Fax 0049-511-532-7274
   & Abt. für experimentelle Otologie, HNO-Klinik
   Medizinische Hochschule Hannover
   Feodor-Lynen Str. 35
   D-30625 Hannover
   E-mail: kral.andrej@mh-hannover.de

Coordination of PhD program “Auditory Sciences”:
   Dr. Christine Baumhoff                        Tel 0049-511-532-7234
   HNO Clinics, OE 6500
   Medizinische Hochschule Hannover
   Carl-Neuberg Str. 1
   D- 30625 Hannover
   E-Mail: baumhoff.christine@mh-hannover.de

-------------------------------------------------------------------------------------
Chairman of PhD program “Epidemiology”:
      Prof. Dr. Gérard Krause                                             Tel 0049-531-6181-3101
      Head of Department of Epidemiology
      and
      Professor for Infectious Disease Epidemiology at the Medical University Hannover
      Helmholtz Centre for Infection Research
      Inhoffenstr. 7
      D-38124 Braunschweig
      E-mail: gerard.krause@helmholtz-hzi.de
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Coordination of PhD program “Epidemiology”:
   Dr. Stefanie Castell & Dr. Jördis Ott              Tel 0049-531-6181-3115
   Helmholtz Centre for Infection Research            Tel 0049-531-6181-3104
   Department of Epidemiology
   Inhoffenstr. 7
   D- 38124 Braunschweig
   E-Mail: phd-epidemiology@helmholtz-hzi.de;
   joerdis.ott@helmholtz-hzi.de; stefanie.castell@helmholtz-hzi.de
   Web: http://www.helmholtz-hzi.de/de/karriere/phd_studiengang_epidemiologie/ziele/

--------------------------------------------------------------------------------------
Members of the MD/PhD program “Molecular Medicine” Commission:
     Prof. Dr. Reinhold E. Schmidt (Chairman)               Prof. Dr. Dr. Thomas Thum (Vice Chairman)
     Prof. Dr. Georg Behrens                                Prof. Dr. Armin Braun
     Prof. Dr. Mathias Gaestel                              Prof. Dr. Dietmar Manstein
     Prof. Dr. Axel Schambach                               Dr. Siegfried Weiß
     Sven Giese / Claudia Schröder                          Inga Hensel
     Anika Alberts                                          NN
Contact / Coordination: Dr. Susanne Kruse and Birgit Müller, Medizinische Hochschule Hannover, PhD Office, OE
9117, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-6011; Fax. -2611; HBRS@mh-hannover.de

Members of the PhD programs “Infection Biology” and “DEWIN” Commission:
     Prof. Dr. Reinhold Förster (Chairman)                  Dr. Günter Bernhardt
     Prof. Dr. Susanne Häußler                              Prof. Dr. Georg Herrler
     Dr. Matthias Lochner                                   Prof. Dr. Thomas Pietschmann
     Prof. Dr. Reinhold E. Schmidt                          Prof. Dr. Thomas F. Schulz
     Prof. Dr. Sebastian Suerbaum (Vice Chairman)           Prof. Dr. Peter Valentin-Weigand
     Francisco Jose Zapatero Belinchon                      Gwendolyn Patzer

Contact / Coordination: Dr. Sabine Johann and Simone Zimmer, Medizinische Hochschule Hannover. ZIB at
Institute of Immunology, OE 5240, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9742; Fax. -9722;
zib@mh-hannover.de

Members of the PhD program “Regenerative Sciences” Commission:
     Prof. Dr. Ulrich Martin (Chairman)                     Prof. Dr. Ina Gruh (Vice Chairwoman)
     Prof. Dr. Hildegard Büning                             Prof. Dr. Tobias Cantz
     Prof. Dr. Boris Chichkov                               Prof. Dr. Birgit Glasmacher
     Prof. Dr. Heiner Niemann                               Prof. Dr. Axel Schambach, PhD
     Prof. Dr. Dagmar Wirth                                 Dr. Gerald Dräger
     Svitlana Malysheva                                     Denise Klatt
     Karsten Cirksena                                       Lika Drakhlis
     Kathrin Haake                                          Santoshi Biswanath

Contact / Coordination: Dr. Daniela Pelz, Mariam Kujenya, Medizinische Hochschule Hannover, REBIRTH Office,
OE 8880, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-5206 / -5202; Fax. -5205, phd-regsci@mh-
hannover.de
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Members of the PhD program “Auditory Sciences” Commission:
     Prof. Dr. Andrej Kral (Chairman)                          Prof. Dr. Thomas Lenarz
     Prof. Dr. Andreas Büchner                                 Prof. Dr. Peter Behrens
     Prof. Dr. Holger Blume                                    Prof. Dr. Reinhard Dengler
     Prof. Dr. Lilli Geworski (Vice Chairwoman)                PD Dr. Athanasia Warneke
     Mathias Voigt
Advisory: Dr. V. Hamacher, Head Advanced Bionics GmbH ERC

Contact / Coordination: Dr. Christine Baumhoff, Medizinische Hochschule Hannover, OE 6500, Carl-Neuberg-Str.
1, 30625 Hannover; Tel. +49-511-532-7234; Baumhoff.Christine@mh-hannover.de

Members of the PhD program “Epidemiology” Commission:
        Prof.Dr. Gérard Krause (chairman)
        Prof. Dr. M. Marschollek                              Dr. Stefanie Castell & Dr. Jördis Ott (coordinators)
        Prof. Dr. Marie-Luise Dierks                          Daniela Gornyk & M.T. Nguyen (students)
        Prof. Dr. Frank Klawonn
        Prof. Dr. Thomas Pietschmann (guest)
        Prof. Dr. Reinhold Schmidt (guest)
        Prof. Dr. Thomas Schulz (guest)

Program Coordination:
Dr. Stefanie Castell & Dr. Jördis Ott
Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7,
D- 38124 Braunschweig; joerdis.ott@helmholtz-hzi.de; stefanie.castell@helmholtz-hzi.de

Program Assistance:
Sylvia Richter; Helmholtz Centre for Infection Research, Department of Epidemiology, Inhoffenstr. 7,
D- 38124 Braunschweig; phd-epidemiology@helmholtz-hzi.de; phone: +49-531-6181-3105
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Content:
                                                                                                                                    Page
Obligatory seminars for PhD programs, Good Scientific Practice ............................. 14
1st Semester MD/PhD „Molecular Medicine“ ............................................................... 15
- in-depth seminars for medical students ...................................................................... 18
- in-depth seminars for life scientists............................................................................. 18
2nd Semester MD/PhD „Molecular Medicine“ .......................................................20
3rd Semester MD/PhD “Molecular Medicine” .......................................................... 22
- Focus Immunology ........................................................................................................ 22
- Focus Genetics and Cell Biology ................................................................................. 25
4th Semester MD/PhD “Molecular Medicine” .......................................................... 28
- Focus Infection and Immunity ...................................................................................... 28
- Focus Differentiation and Oncology ............................................................................ 30

1st Semester PhD “Infection Biology / DEWIN”.................................................... 32
2nd Semester PhD “Infection Biology / DEWIN” ................................................... 35
3rd Semester PhD “Infection Biology/ DEWIN”........................................................ 36
4th Semester PhD “Infection Biology/ DEWIN” ........................................................ 38

1st Semester PhD “Regenerative Sciences” ............................................................ 40
2nd Semester PhD “Regenerative Sciences” ........................................................... 43
3rd Semester PhD “Regenerative Sciences” ............................................................ 46
4th Semester PhD “Regenerative Sciences” ............................................................ 48
Additional Offers PhD “Regenerative Sciences” .................................................... 50

PhD program “Auditory Sciences” ........................................................................... 51

PhD program “Epidemiology” ................................................................................... 56

Specific seminars ............................................................................................................ 57
- organised by HBRS ....................................................................................................... 57
Optional courses .............................................................................................................. 58

Rules and Requirements ................................................................................................. 59

Map .................................................................................................................................... 66
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                               Curriculum MD/PhD “Molecular Medicine”
1st year
                   1st sem.                            2nd sem.

       Immunology /Stem Cell Biology /                                                       Basics in Molecular Medicine (Focus on
       Bacteriology / Virology                  Cell Biology / Genetics/
                                                Biochemistry/ Methods                        Methods); Seminar, 2hrs

                                                                                             Tutorial, 1h

 In parallel: special in-depth seminars for medical                             Tutorial for the respective seminar/tutorial series
 Students, respectively students from life sciences

2nd year                3rd sem.                       4th sem.

                                                                                              1. Focus: Immunology
                  or
                                                                                              2. Focus: Genetics & Cell Biology

                                                                                              3. Focus: Infection
                                                                  or
                                                                                              4. Focus: Differentiation & Oncology
                                                                           For all: Seminar, 2hrs and Tutorial, 1h

3rd year: concentration on individual research projects

               Structure of the MD/PhD program „Molecular Medicine“

               Year 1                                                  Year 2                                                 Year 3

• Sem. + Lect. in basic sciences
Monday (4.30 - 6.00 pm; 6 cp)
• Tutorials Mondays; until
Christmas separate tutorials for
medical students and life                             • Complex and clinical system;
scientists                                            choice between the foci
(3.15- 4.15 pm; 2 cp)                                 Immunology, Infection, Oncology
                                                      and Differentiation, Cell Biology /
                                                      Genetics, Biochemistry
                                                      Mondays, Seminar and Tutorial
                                                      (3.00 - 6.00 pm; 8 cp)

• 3-year PhD project work (125 cp)
• Three presentations in department over three years (10 cp)
• Three presentations of manuscripts at the departments Journal Club over three years (3 cp)
• Public annual presentation / project report (10 cp)
• Talk / presentation at international congress (2 cp)
• Project-orientated seminars / courses; including practicals (80 h, 8 cp)
• Participation in summer schools / interdisciplinary seminars (e. g. soft skills) / congress (60 h, 6 cp)

                                                                                 Intermediate exam after 18 months
 cp: credit points
                                                                                     PhD thesis and final exam after 3 years
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                    Curriculum PhD “Infection Biology” and “DEWIN”

                                                        1st Year

                              1st Semester                              2nd Semester
                                 Weekly seminars:
                                                                               Project reports &
                             Immunology / Microbiology /
                                                                             special topic lectures
                               Virology / Cell Biology

                                                        2nd Year

                             3rd Semester                               4th Semester
                                Presentation of
                             original manuscripts
                                                                          Project reports
                                       &
                                research topics

          Structure of the PhD Program “Infection Biology“ and “DEWIN”

              Year 1                                     Year 2                                  Year 3

• Sem. + Lect. Monday                       • Seminar based on reviews and
    (4.30 – 6.00 pm; 6 cp)                   original manuscripts
• Journal Club in students own               (Monday 4.30 – 6.00 pm) (4 cp)
 department (15 h) + attendance             • Presentation of one original
 of 15 scientific lect. at MHH /             manuscript and one research topic
HZI / TiHo (such as SFB-Sem. or              during these seminars (4 cp)
 Immunol. Colloquium; 2 cp)                  Journal Club in students own
                                             department (15 h) + attendance
                                             of 15 scientific lect. at MHH / HZI /
                                             TiHo (such as SFB-Sem. or
                                             Immunol. Colloquium; 2 cp)

•    3-year PhD project work (125 cp)
•    Public presentations/project reports (i.e. Retreat) (10 cp)
•    Three presentations in department over three years (10 cp)
•    Three presentations of manuscripts at the departments Journal Club over three years (3 cp)
•    Talk / presentation at international congress (2 cp)
•    Practical courses (80 hours) (10 cp)
•    Participation in summer schools / interdisciplinary seminars (e. g. soft skills) / congress (20h) (2 cp)

                                                                 Intermediate exam after 18 months
cp: credit points
                                                                        PhD thesis and final exam after 3 years
12
              Structure of the PhD-Program “Regenerative Sciences”

            Year 1                                     Year 2                                 Year 3

•   Seminars + Lectures in basic          •   Seminars + Lectures in basic        Focus on experimental work
    sciences                                  sciences
    Thursday (4.15 - 5.45 pm)                 Thursday (4.15 - 5.45 pm)
•   Tutorials                             •   Tutorials
    Thursday (3.00- 4.00 pm)                  Thursday (3.00 - 4.00 pm)

•   3-year PhD project work
•   Three presentations in department within three years (regular attendance)
•   3 Presentations of manuscripts at the department’s Journal Club within three years (regular participation,
    i. e. 10 times per year)
•   Public annual presentation/project report (i. e. retreat)
•   Talk / presentation at international congress
•   Project-orientated seminars / courses; including practicals and summer schools (80 h)
•   Participation in interdisciplinary seminars (e.g. soft skills / congresses) (40h)

                                                                      Intermediate exam after 18 months

                                                                      PhD thesis and final exam after 3 years

You may replace up to 30 hours of the Thursday seminars and
tutorials by the additional offers

”Meet the Investigator” or “Method based seminar”

see page 50
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- three year research project
- three project presentations over the three year time period
- active participation in Journal Clubs, i.e. presentation of manuscripts or workshop outcomes
- active participation in scientific conferences, i. e. poster or oral presentation
- annual PhD-Retreats
- soft skill courses
- program modules (lectures, field work, and courses)
 total accompanying program of a minimum of 300 hrs
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!!Obligatory!!

Good Scientific Practice

For all HBRS PhD and StrucMed students

Introduction, Overview, Basics, Data Management, Ethics

Lecturers: Dr. Beate Schwinzer, Dr. Stephan Halle and Dr. Olga Halle

Tuesday, 23 October 2018
9.00 am     First Seminar: Good Scientific Practice
- 10.30 am Introduction and Data Management; Beate Schwinzer
            Lecture Hall A, building J2

Wednesday, 24 October 2018
9.00 am     Second Seminar: Good Scientific Practice
- 10.30 am Scientific Misconduct and Plagiarism; Beate Schwinzer
            Lecture Hall A, building J2

Thursday, 25 October 2018
9.00 pm     Third Seminar: Good Scientific Practice
- 10.30 am Ethics and Statistics; Dr. Stephan and Dr. Olga Halle
            Lecture Hall A, building J2
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MD/PhD ”Molecular Medicine”
1st Semester
Note: The curriculum of the first year is more orientated towards basics and methods in the different
diciplines.

MD/PhD “Molecular Medicine”: There are some alternative in-depth seminars / tutorials on Mondays for
medical students and students from life sciences until Christmas (see pages 17 / 18) and the respectives
tutorial for the seminars.

  Episode I – The hematopoetic
  wonderland                                         Monday,
                                         Seminar                        4.30 – 6.00 pm     Christine Falk
  (Focus Immunology I)                               08.10.2018

            HBRS Opening: Monday, 15 October 2018, 5.00 pm (building J6, Level S0, lecture hall R)

  What innate immune cells can do for
                                                     Monday,
  you                                    Seminar                        4.30 – 6.00 pm     Inga Sandrock
                                                     22.10.2018
  (Focus Immunology II)

  B cells and antibody responses                     Monday,
                                         Seminar                        4.30 – 6.00 pm     Siegfried Weiß
  (Focus Immunology III)                             29.10.2018

  T cells and T cell response
                                                     Monday,
  (Focus Immunology IV)                  Seminar                        4.30 – 6.00 pm     Francesca Rampoldi
                                                     05.11.2018

  Cytotoxic T cell response                          Monday,
                                         Seminar                        4.30 – 6.00 pm     Berislav Bosnjak
  (Focus Immunology V)                               12.11.2018

  Now you have the choice between either Oncology *or * Microbiology:

  In HBRS Seminar room (Oncology):

  Gene expression analysis in cancer                 Monday,
                                         Seminar                          4.30 – 6.00 pm   Adrian Schwarzer
  research (Focus Oncology I)                        19.11.2018

  Genetic modification with lentiviral
                                                     Monday,
  vector technologies                    Seminar                          4.30 – 6.00 pm   Tobias Mätzig
                                                     26.11.2018
  (Focus Oncology II)

  Design and application of shRNA-
                                                     Monday,
  based methods in biomedical            Seminar                          4.30 – 6.00 pm   Marc Jens Klepper?
                                                     03.12.2018
  research (Focus Oncology III)
16
Disease modeling and drug
                                                Monday,
discovery with the CRISPR-Cas9        Seminar                4.30 – 6.00 pm   Dirk Heckl
                                                10.12.2018
system (Focus Oncology IV)

Induced pluripotent stem cell
resources for the treatment of                  Monday,
                                      Seminar                4.30 – 6.00 pm   Nico Lachmann
congenital diseases                             17.12.2018
(Focus Oncology V)

Mouse models                                    Monday,
                                      Seminar                4.30 – 6.00 pm   Arnold?
(Focus Oncology VI)                             07.01.2019

In lecture hall B (Microbiology):

                                                Monday,
Common themes in bacterial            Seminar                4.30 – 6.00 pm   Günter Graßl
                                                19.11.2018
pathogenesis (Focus Microbiology I)

Paradigms of Infection Biology:                 Monday,
                                      Seminar                4.30 – 6.00 pm   Fritz Bange
Myobacteria                                     26.11.2018
(Focus Microbiology II)

Paradigms of Infection Biology:
                                                Monday,
Chlamydia and Listeria                Seminar                4.30 – 6.00 pm   Andreas Klos
                                                03.12.2018
(Focus Microbiology III)

Paradigms of Infection Biology:
                                                Monday,                       Peter
Streptococci and Staphylococci        Seminar                4.30 – 6.00 pm
                                                10.12.2018                    Valentin-Weigand
(Focus Microbiology IV)

Paradigms of Infection Biology:
                                                Monday,
Toxoplasma                            Seminar                4.30 – 6.00 pm   Dirk Schlüter
                                                17.12.2018
(Focus Microbiology V)

Paradigms of Infection Biology:
                                                Monday,
Salmonella                            Seminar                4.30 – 6.00 pm   Günther Graßl
                                                07.01.2019
(Focus Microbiology VI)
17
Taxonomy of Viruses and Viral                        Monday,
Diseases                                 Seminar                         4.30 – 6.00 pm   Anke Kraft
                                                     14.01.2019
(Focus Virology I)
                                                     Monday,
                                         Tutorial                        3.15 – 4.15 pm   Anke Kraft
                                                     21.01.2019
                                                     Monday,
                                         Seminar                         4.30 – 6.00 pm   Thomas Krey
Virus Cell Entry + Structural                        21.01.2019
Virology (not Flaviviridae)
(Focus Virology II)                                  Monday,
                                         Tutorial                        3.15 – 4.15 pm   Thomas Krey
                                                     28.01.2019

                                                     Monday,
Transcription + Replication of RNA       Seminar                         4.30 – 6.00 pm   Thomas Pietschmann
                                                     28.01.2019
viruses (not Flaviviridae)
(Focus Virology III)                                 Monday,
                                         Tutorial                        3.15 – 4.15 pm   Thomas Pietschmann
                                                     04.02.2019

                                                     Monday,
                                         Seminar                         4.30 – 6.00 pm   Jens Bohne
Transcription + Replication of DNA                   04.02.2019
(not Herpesviridae)
(Focus Virology IV)                                  Monday,
                                         Tutorial                        3.15 – 4.15 pm   Jens Bohne
                                                     11.02.2019

                                                     Monday,
                                         Seminar                         4.30 – 6.00 pm   Gisa Gerold
Virus assembly, maturation, egress                   11.02.2019
(not Flaviviridae7Herpesviridae)
(Focus Virology V)                                   Monday,
                                         Tutorial                        3.15 – 4.15 pm   Gisa Gerold
                                                     18.02.2019

                                                     Monday,
Pathogenesis, Host Defense, Viral        Seminar                         4.30 – 6.00 pm   Abel Viejo-Borbolla
                                                     18.02.2019
Interference
(not Herpes)                                         Monday,
(Focus Virology VI)                      Tutorial                        3.15 – 4.15 pm   Abel Viejo-Borbolla
                                                     25.02.2019

The cell cycle and its implications in
                                                     Monday,
diseases                                 Seminar                         4.30 – 6.00 pm   Hans J. Hauser
                                                     25.02.2019
(Focus Cell Biology I)

Location seminar: Lecture hall B, building J2
Location tutorial: HBRS seminar room 1140, building J4, level 01 (2nd floor)
18

*For MD/PhD “Molecular Medicine” medical students only: Some more basics in life
sciences

As there are not many medical students this year, we will arrange an individual program for you!
Or you visit the tutorials for life scientists
Mondays, 3.15 - 4.15 pm

** For PhD students from life sciences only: Some basics in medicine / techniques

 For MD/PhD “Molecular Medicine”                    Monday,
                                       Seminar                     3.30 – 4.15 pm     Susanne Kruse
 only:                                              08.10.2018
 General introduction, lectures,
 expectations etc.: answering of all   No seminar
 last questions, election of class     because of   Monday,
 speaker                               opening      15.10.2018
                                       ceremony

                                                    Monday,
 Electron Microscopy                   Seminar                     3.15 – 4.15 pm     Stephanie Groos
                                                    22.10.2018

                                                    Monday,
 No tutorial                           Seminar                     3.15 – 4.15 pm
                                                    29.10.2018
                                       No seminar
                                       because of   Monday,
                                       animal       05.11.2018
                                       course

 Clinical Immunology: pathogenesis
                                                    Monday,
 of an autoimmune disease (Lupus       Seminar                     3.15 – 4.15 pm     Torsten Witte
                                                    12.11.2018
 erythematosus)

                                                    Monday,
 Hannover Unified Biobank              Seminar                     3.15 – 4.15 pm     Thomas Illig
                                                    19.11.2018

                                                    Monday,
 Super resolution light microscopy     Seminar                     3.15 – 4.15 pm     Rudolf Bauerfeind
                                                    26.11.2018
19

                                                  Monday,
Gene Technology and Biosafety        Seminar                         3.15 – 4.15 pm     Ruth Knorr
                                                  03.12.2018

                                                  Monday,
FACS analysis                        Seminar                         3.15 – 4.15 pm     Roland Jacobs
                                                  10.12.2018

                                                  Monday,
Chip cytometry                       Seminar                         3.15 – 4.15 pm     Christian Hennig
                                                  17.12.2018

                                                  Monday,
Cell sorting                         Seminar                         3.15 – 4.15 pm     Matthias Ballmaier
                                                  07.01.2019

Immunotherapy and cancer                          Monday,
                                     Seminar                         3.15 – 4.15 pm     Tetyana Yevsa
vaccines                                          14.01.2019

Location: Hannover Biomedical Research School, HBRS seminar room 1140, building J4, level 01 (2nd floor)
20

MD/PhD Molecular Medicine

2nd Semester
MD/PhD MM: Please attend all of the seminars and tutorials listed below.

  4.) General Cell Biology

                                                          Monday,
                                         Tutorial                          3.15 – 4.15 pm   Hans J. Hauser
                                                          01.04.2019

                                         Seminar          Monday,
                                                                           4.30 – 6.00 pm   Melanie Brinkmann
                                         lecture hall B   01.04.2019
  Intracellular trafficking
                                         Tutorial
                                                          Monday,
                                         HBRS                              3.15 – 4.15 pm   Melanie Brinkmann
                                                          08.04.2019
                                         seminar room

                                         Seminar          Monday,
                                                                           4.30 – 6.00 pm   Theresia Stradal
                                         lecture hall B   08.04.2019
  The structure of the cell’s interior
                                                          Monday,
                                         Tutorial                          3.15 – 4.15 pm   Theresia Stradal
                                                          15.04.2019
                                         No seminar
                                         on April 15th,
                                         only tutorial!
                                         Public
                                         holiday on
                                         April 22nd

  (Now for MD/PhD MM only)
  All seminars and tutorials in
  HBRS seminar -room

  5.) Biochemistry and Genetics;
  methods

                                                          Monday,
                                         Seminar                           4.30 – 6.00 pm   Robert Geffers (HZI)
                                                          29.04.2019
  Next generation sequencing
                                                          Monday,
                                         No tutorial
                                                          06.05.2019

  Transcriptomics                                         Monday,                           Oliver Dittrich-
                                         Seminar                           4.30 – 6.00 pm
                                                          06.05.2019                        Breiholz
  (seminar / tutorial in building J3,
                                                                                            Oliver Dittrich-
  level 01, room 2020)                   Tutorial         13.05.2019       3.15 – 4.15 pm
                                                                                            Breiholz
21
                                         Seminar /    Monday,
                                                                       4.30 – 6.00 pm    Achim Gossler
                                         tutorial     13.05.2019
Strategies to analyse gene function
in vivo
                                         Tutorial     20.05.2019       3.15 – 4.15 pm    Achim Gossler

                                                      Monday,
Proteomics                               Seminar                       4.30 – 6.00 pm    Andreas Pich
                                                      20.05.2019

                                                      Monday,
Metabolomics                             Tutorial                      3.15 – 4.15 pm    Heike Bähre
                                                      27.05.2019

                                                      Monday,
                                         Seminar                       4.30 – 6.00 pm    Ute Curth
                                                      27.05.2019
Physical Methods in Biochemistry
                                                      Monday,
                                         Tutorial                      3.15 – 4.15 pm    Ute Curth
                                                      03.06.2019

                                                      Monday,
                                         Seminar                       4.30 – 6.00 pm    NN
                                                      03.06.2019
NN
                                                      Monday,
                                         Tutorial                      3.15 – 4.15 pm    NN
                                                      17.06.2019
                                         No
                                         seminar /
                                         tutorial,
                                         public
                                         holiday on
                                         June 10th
                                                      Monday,                            Christian Wahl-
tba                                      Seminar                       4.30 – 6.00 pm
                                                      17.06.2019                         Schott
(seminar only - building J6, level S0,
room 76)                                              Monday,                            Christian Wahl-
                                         Tutorial                      3.15 – 4.15 pm
                                                      24.06.2019                         Schott
                                                      Monday,
                                         Seminar                       4.30 – 6.00 pm    Axel Schambach
                                                      24.06.2019
Stem cells
                                                      Monday,
                                         Tutorial                      3.15 – 4.15 pm    Axel Schambach
                                                      01.07.2019
                                         Seminar /    Monday,
                                                                       4.30 – 6.30 pm    Jan Fiedler
                                         Tutorial     01.07.2019
Techniques of miRNAs and IncRNAs

Location: Hannover Biomedical Research School, HBRS seminar room 1140, building J4, level 01 (2nd floor)
22

MD/PhD program “Molecular Medicine”

3rd Semester
Note: The curriculum of the second year is more orientated towards research and applied aspects in the
different disciplines. Every student has the choice between two major foci each semester. You may vary in
the choice of modules between the two foci. Please, choose the ones most appropriate for you and your
project!

1. Focus: Immunology

                               Opening Ceremony of HBRS, Monday, 15 October 2018, 5.00 pm

  1. Immune cells and organs

                                                      Monday,
                                        Seminar                           3.00 – 5.00 pm    Roland Jacobs
                                                      22.10.2018
  Regulation and function of NK cells
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm    Roland Jacobs
                                                      29.10.2018

                                                      Monday,
                                        Seminar                           3.00 – 5.00 pm
                                                      29.10.2018
  No seminar
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm
                                                      05.11.2018

  Calcium signalling and autoimmune                   Monday,             3.00 – 5.00 pm
                                        Seminar                                             Georgios Sogkas
  inflammation                                        05.11.2018

                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm    Georgios Sogkas
                                                      12.11.2018
23

2. Autoimmunity

                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Fatih Noyan
Transplantation, Tolerance and                    12.11.2018
Tregs
                                                  Monday,
                                      Tutorial                 5.00 – 6.00 pm   Fatih Noyan
                                                  26.11.2018

                                      Seminar /   Monday,                       Fritz Melchers
T and B cell differentiation                                   3.00 – 6.00 pm
                                      Tutorial    19.11.2018                    (Basel)

                                                  Monday,                       Constanza Ferreira
                                      Seminar                  3.00 – 5.00 pm
Major histocompatibility complex in               26.11.2018                    de Figueiredo
tolerogenic cell therapies
                                                  Monday,                       Constanza Ferreira
                                      Tutorial                 5.00 – 6.00 pm
                                                  03.12.2018                    de Figueiredo

3. Allergy and Asthma,
Immunological diseases

                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Thomas Werfel
                                                  03.12.2018
Immunodermatology
                                                  Monday,
                                      Tutorial                 5.00 – 6.00 pm   Lennart Rösner
                                                  10.12.2018

                                                  Monday,                       Armin Braun
                                      Seminar                  3.00 – 5.00 pm
Neuroimmune interactions in                       10.12.2018                    (Fraunhofer Institute)
asthma bronchiale                                 Monday,                       Armin Braun
                                      Tutorial                 5.00 – 6.00 pm
                                                  17.12.2018                    (Fraunhofer Institute)

                                                  Monday,                       Olga Halle /
                                      Seminar                  3.00 – 5.00 pm
Studying allergic airway                          17.12.2018                    Anna-Maria Dittrich
inflammation: of mice and man                     Monday,                       Olga Halle /
                                      Tutorial                 5.00 – 6.00 pm
                                                  07.01.2019                    Anna-Maria Dittrich

                                                  Monday,                       Ulrich Kalinke /
                                      Seminar                  3.00 – 5.00 pm
                                                  07.01.2019                    Annett Ziegler
Adjuvants
                                                  Monday,                       Ulrich Kalinke /
                                      Tutorial                 5.00 – 6.00 pm
                                                  14.01.2019                    Annett Ziegler
24

4. Signalling and therapy

                                                   Monday,
                                      Seminar                          3.00 – 5.00 pm   Christine Herzog
                                                   14.01.2019
Fibulin 6 affects TGF signalling in
context of cardia remodelling
                                                   Monday,
                                      Tutorial                         5.00 – 6.00 pm   Christine Herzog
                                                   21.01.2019

                                                   Monday,
Inhibitory receptor-ligand            Seminar                          3.00 – 5.00 pm   Reinhard Schwinzer
                                                   21.01.2019
interactions as targets for
transplantation tolerance                          Monday,
                                      Tutorial                         5.00 – 6.00 pm   Reinhard Schwinzer
                                                   28.01.2019

                                                   Monday,
                                      Seminar                          3.00 – 5.00 pm   Andreas Klos
                                                   28.01.2019
The complement system and its
regulation
                                                   Monday,
                                      Tutorial                         5.00 – 6.00 pm   Andreas Klos
                                                   04.02.2019

                                                   Monday,
Acute kidney injury in                Seminar                          3.00 – 5.00 pm   Faikah Güler
                                                   04.02.2019
transplantation - molecular
mechanisms                                         Monday,
                                      Tutorial                         5.00 – 6.00 pm   Faikah Güler
                                                   11.02.2019

                                                   Monday,
                                      Seminar                          3.00 – 5.00 pm   Christine Falk
Tumor immunity and oncogenic                       11.02.2019
signalling                                         Monday,
                                      Tutorial                         5.00 – 6.00 pm   Christine Falk
                                                   18.02.2019

Location: Hannover Biomedical Research School, building J4, level S0 (ground floor), seminar room S 1400
(right to the main entrance)
25
2. Focus: Genetics and Cell Biology

 1. Techniques and diagnostics /
 therapy

                                        Seminar /    Monday,
                                                                         3.00 - 6.00 pm   Heiner Niemann
 Embryonic and somatic cloning in       Tutorial     08.10.2018
 mammals

                         Opening Ceremony, Monday, 15 October 2018, 5.00 pm, lecture hall R

                                                     Monday,
                                        Seminar                          3.00 – 5.00 pm   Yulia Kiyan
 Molecular mechanisms of vascular                    22.10.2018
 aging in health and disease
                                                     Monday,
                                        Tutorial                         5.00 – 6.00 pm   Yulia Kiyan
                                                     29.10.2018

 2. Genetics

                                                     Monday,
                                        Seminar                          3.00 – 5.00 pm   Dirk Heckl
                                                     29.10.2018
 Application of genome editing in
 biomedical research
                                                     Monday,
                                        Tutorial                         5.00 – 6.00 pm   Dirk Heckl
                                                     05.11.2018

                                        Seminar /    Monday,
                                                                         2.00 – 5.00 pm   Roland Schmitt
                                        Tutorial     05.11.2018
 Stem cells in renal injury

                                                     Monday,
                                        Seminar                          3.00 – 5.00 pm   Melanie Ricke-Hoch
 Molecular mechanisms of heart                       12.11.2018
 failure
                                                     Monday,
                                        Tutorial                         5.00 – 6.00 pm   Melanie Ricke-Hoch
                                                     19.11.2018

 3. Signalling

                                        Seminar /    Monday,
 Interactions between signalling,                                        2.00 – 5.00 pm   Asha Balakrishnan
                                        Tutorial     19.11.2018
 metabolic pathways and miRNAs in
 HCC
26
                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Frank Echtermeyer
Functions of sodium channel Nav1.3                26.11.2018
in neutrophil extravasation during
ischemia                                          Monday,
                                      Tutorial                 5.00 – 6.00 pm   Frank Echtermeyer
                                                  03.12.2018

                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Harald Genth
Small GTPases as targets of                       03.12.2018
bacterial toxins
                                                  Monday,
                                      Tutorial                 5.00 – 6.00 pm   Harald Genth
                                                  10.12.2018

                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Hans Bakker
                                                  10.12.2018
Glycosylation and diseases
                                                  Monday,
                                      Tutorial                 5.00 – 6.00 pm   Hans Bakker
                                                  17.12.2018

4. Cell Biology and disease

                                                  Monday,
                                      Seminar                  3.00 – 5.00 pm   Maren Leifheit-Nestler
Molecular mechanisms in                           17.12.2018
cardiorenal syndrome
                                                  Monday,
                                      Tutorial                 5.00 – 6.00 pm   Maren Leifheit-Nestler
                                                  07.01.2019

                                                  Monday,                       Elena Lopez-
                                      Seminar                  3.00 – 5.00 pm
Looking closely at the lung and its               07.01.2019                    Rodriguez
surfactant system
                                                  Monday,                       Elena Lopez-
                                      Tutorial                 5.00 – 6.00 pm
                                                  14.01.2019                    Rodriguez

                                      Seminar /   Monday,
                                                               5.00 – 7.00 pm   Dietmar Manstein
                                      Tutorial    21.01.2019
How molecular motors work
27

                                                    Monday,
                                      Seminar                           3.00 – 5.00 pm    Robert Lindner
                                                    21.01.2019
Membrane domains
                                                    Monday,
                                      Tutorial                          5.00 – 6.00 pm    Robert Lindner
                                                    28.01.2019

                                                    Monday,
                                      Seminar                           3.00 – 5.00 pm    Thomas Thum
Micro RNAs from disease                             28.01.2019
mechanisms to therapeutic
approaches                                          Monday,
                                      Tutorial                          5.00 – 6.00 pm    Jan Fiedler
                                                    04.02.2019

                                                    Monday,
                                      Seminar                           3.00 – 5.00 pm    Beate Vajen
                                                    04.02.2019
Epigenetics and Cancer
                                                    Monday,
                                      Tutorial                          5.00 – 6.00       Beate Vajen
                                                    11.02.2019

                                                    Monday,
                                      Seminar                           3.00 – 5.00 pm    Ingmar Mederacke
                                                    11.02.2019
Liver fibrogenesis - basic
mechanisms and clinical
implications
                                                    Monday,
                                      Tutorial                          5.00 – 6.00       Ingmar Mederacke
                                                    18.02.2019

Location: Hannover Biomedical Research School, building J4, level 01 (2nd floor), seminar room 1031
28

MD/PhD program “Molecular Medicine”

4th Semester
3. Focus: Infection and Immunity

 1. Innate Immunity; Infection and
 disease

                                                       Monday,
                                         Seminar                           3.00 – 5.00 pm   Siegfried Weiß
                                                       08.04.2019
 Evolutionary aspects of the immune
 system
                                                       Monday,                              Siegfried Weiß
                                         Tutorial                          5.00 – 6.00 pm
                                                       15.04.2019

                                                       Monday,                              Thomas
                                         Seminar                           3.00 – 5.00 pm
                                                       15.04.2019                           Pietschmann
 Virus replication, antivirals and
 resistence
                                                       Monday,                              Thomas
                                         Tutorial                          5.00 – 6.00 pm
                                                       29.04.2019                           Pietschmann

                                 No seminars on 22 April 2019 due to public holiday

                                                       Monday,
                                         Seminar                           3.00 – 5.00 pm   Reinhold E. Schmidt
                                                       29.04.2019
 Immune response in HIV
                                                       Monday,
                                         Tutorial                          5.00 – 6.00 pm   Reinhold E. Schmitt
                                                       06.05.2019

                                                       Monday,
 Acute and chronic bacterial infection   Seminar                           3.00 – 5.00 pm   Ulrich Maus
                                                       06.05.2019
 of the lung (Location: Experimental
 Pneumology, Feodor-Lynen-Str. 21;
 building M05, level 02, room 213)                     Monday,
                                         Tutorial                          5.00 – 6.00 pm   Ulrich Maus
                                                       13.05.2019

                                                       Monday,
                                         Seminar                           3.00 – 5.00 pm   Christine Goffinet
                                                       13.05.2019
 Innate Immunity to viral infections
                                                       Monday,
                                         Tutorial                          5.00 – 6.00 pm   Christine Goffinet
                                                       20.05.2019

                                                       Monday,
                                         Seminar                           3.00 – 5.00 pm   Thomas Wirth
 Role of CD8 T cells in acute and                      20.05.2019
 chronic infections
                                                       Monday,
                                         Tutorial                          5.00 – 6.00 pm   Thomas Wirth
                                                       27.05.2019
29
2. Genetics and disease, infection
and immune system

                                                     Monday,
                                        Seminar                           3.00 – 5.00 pm   Dagmar Wirth (HZI)
                                                     27.05.2019
Genetic engineering of cells and
mice for development of disease
models                                               Monday,
                                        Tutorial                          5.00 – 6.00 pm   Dagmar Wirth (HZI)
                                                     03.06.2019

                               No seminars on 10th June 2019 due to public holiday

                                        Seminar /    Monday,
                                                                          5.00 – 7.00 pm   Renata Stripecke
                                        Tutorial     17.06.2019
Viral vectors for gene transfer in
vitro and vivo

                                                     Monday,
                                        Seminar                           3.00 – 5.00 pm   Carlos Guzman (HZI)
                                                     17.06.2019
Basic concepts in vaccinology
                                                     Monday,
                                        Tutorial                          5.00 – 6.00 pm   Carlos Guzman (HZI)
                                                     24.06.2019

                                                     Monday,
                                        Seminar                           3.00 – 5.00 pm   Peggy Riese (HZI)
                                                     24.06.2019
Innate lymphoid cells and their role
in viral infection and vaccine design
                                                     Monday,
                                        Tutorial                          5.00 – 6.00 pm   Peggy Riese (HZI)
                                                     01.07.2019

                                                     Monday,
                                        Seminar                           3.00 – 5.00 pm   Eva Medina (HZI)
                                                     01.07.2019
Host-pathogen interactions
                                                     Monday,
                                        Tutorial                          5.00 – 6.00 pm   Eva Medina (HZI)
                                                     08.07.2019

Location: Hannover Biomedical Research School, building J4, level S0 (ground floor), seminar room S 1400
(right to the main entrance)
30

4. Focus: Differentiation and Oncology

 1. Development and cancer

                                                      Monday,
                                        Seminar                           3.00 – 5.00 pm   Tetyana Yevsa
                                                      08.04.2019
 Cellular senescence as a barrier for
 cancer development
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Tetyana Yevsa
                                                      15.04.2019

                                                      Monday,                              Michael Ott
                                        Seminar                           3.00 – 5.00 pm
 Liver organogenesis and hepatic                      15.04.2019
 stem cell
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Michael Ott
                                                      29.04.2019

                                No seminars on 22 April 2019 due to public holiday

                                                      Monday,
                                        Seminar                           3.00 – 5.00 pm   Ulrich Lehmann
                                                      29.04.2019
 Epigenetics in cancer
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Ulrich Lehmann
                                                      06.05.2019

 2. Stem cells and cancer

 Onco-Immunology: Translational                       Monday,
 research at the interface between      Seminar                           3.00 – 5.00 pm   Friedrich Feuerhake
                                                      06.05.2019
 immunology and oncology
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Friedrich Feuerhake
                                                      13.05.2019

                                                      Monday,
                                        Seminar                           3.00 – 5.00 pm   Anuhar Chaturvedi
 Metabolism and cancer: concept,                      13.05.2019
 players, therapy
                                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Anuhar Chaturvedi
                                                      20.05.2019

                                                      Monday,
 Adoptive T cell therapies in           Seminar                           3.00 – 6.00 pm   Martin Sauer
                                                      20.05.2019
 hematopoietic stem cell
 transplantation                                      Monday,
                                        Tutorial                          5.00 – 6.00 pm   Martin Sauer
                                                      27.05.2019
31
                                                    Monday,
                                        Seminar                         3.00 – 5.00 pm   Dirk Heckl
                                                    27.05.2019
Application of genome editing in
biomedical research
                                                   Monday,
                                        Tutorial                        5.00 – 6.00 pm   Dirk Heckl
                                                   03.06.2019

3. Signalling (and cancer)

                                                    Monday,
                                        Seminar                         3.00 – 5.00 pm   Matthias Eder
                                                    03.06.2019
Oncogenes and myeloproliferation
                                                   Monday,
                                        Tutorial                        5.00 – 6.00 pm   Matthias Eder
                                                   17.06.2019

                              No seminars on 10 June 2019 due to public holiday

                                                    Monday,
                                        Seminar                         3.00 – 5.00 pm   Andreas Kispert
T-box genes in development and                      17.06.2019
disease
                                                   Monday,
                                        Tutorial                        5.00 – 6.00 pm   Andreas Kispert
                                                   24.06.2019

                                                    Monday,
                                        Seminar                         3.00 – 5.00 pm   Manoj Menon
Physiological functions of the septin               24.06.2019
cytoskeleton
                                                   Monday,
                                        Tutorial                        5.00 – 6.00 pm   Manoj Menon
                                                   01.07.2019

                                                    Monday,
                                        Seminar                         3.00 – 5.00 pm   Adrian Schwarzer
                                                    01.07.2019
Molecular basis of leukemogenesis
                                                   Monday,
                                        Tutorial                        5.00 – 6.00 pm   Adrian Schwarzer
                                                   08.07.2019

Location: Hannover Biomedical Research School, building J4, level 01 (2nd floor), seminar room 1031
32

PhD programs “Infection Biology / DEWIN”

                                               1st Semester
Tutorials: Mondays, 15:15-16:15 hrs                               Seminars: Mondays, 16:30-18:00 hrs
Location: Room 1140, Building J4, level1                          Location: Lecture Hall B, Building J2

DATE         TYPE         FOCUS                LECTURER          SUBJECT

08.10.2018   Seminar      Immunology I         Falk              Episode I - The hematopoetic wonderland

16.10.2017   HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R)

22.10.2018   Seminar      Immunology II        Sandrock          Innate Immunity

29.10.2018   Seminar      Immunology III       Weiß              B cells and antibody responses

05.11.2018   Seminar      Immunology IV        Rampoldi          T cells and T cell response

12.11.2018   Seminar      Immunology V         Bosnjak           Cytotoxic T cell response

19.11.2018   Seminar      Microbiology I       Graßl             Common Themes in Microbial Pathogenesis

26.11.2018   Seminar      Microbiology II      Bange             Paradigms in Infection Biology: Mycobacteria

                                                                 Paradigms in Infection Biology: Chlamydia and
03.12.2018   Seminar      Microbiology III     Klos
                                                                 Listeria
33

DATE         TYPE      FOCUS             LECTURER         SUBJECT

                                         Valentin-        Paradigms in Infection Biology: Streptococci and
10.12.2018   Seminar   Microbiology IV
                                         Weigand          Staphylococci

17.12.2018   Seminar   Microbiology V    Schlüter         Paradigms in Infection Biology: Toxoplasma

07.01.2019   Seminar   Microbiology VI   Graßl            Paradigms in Infection Biology: Salmonella

14.01.2019   Seminar   Virology I        Kraft            Taxonomy of Viruses and Viral Diseases

21.01.2019   Seminar   Virology II       Krey             Structural Virology + Virus Cell Entry

                                                          RNA Virus Transcription + Replication (not
28.01.2019   Seminar   Virology III      Pietschmann
                                                          Flaviviridae)

                                                          DNA Virus Transcription + Replication (not
04.02.2019   Seminar   Virology IV       Bohne
                                                          Herpesviridae)

                                                          Virus assembly, maturation and egress (not
11.02.2019   Seminar   Virology V        Gerold
                                                          Flavi/Herpesviridae)

                                                          Viral Pathogenesis and Host Defenses (not
18.02.2019   Seminar   Virology VI       Viejo-Borbolla
                                                          Flavi/Herpesviridae)

25.02.2019   Seminar   Cell Biology I    Hauser           The cell cycle and its implications in diseases
34
  PhD Programs “Infection Biology / DEWIN”

                                                  2nd Semester
Tutorials: Mondays, 15:15-16:15 hrs                                Seminars: Mondays, 16:30-18:00 hrs
Location: Room 1140, Building J4, level1                           Location: Lecture Hall B, Building J2

DATE         TYPE                   FOCUS              LECTURER    SUBJECT

01.04.2019   Seminar                Cell Biology II    Brinkmann   Intracellular trafficking

08.04.2019   Seminar                Cell Biology III   Stradal     The structure of the cell's interior

 Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420

DATE         FOCUS                  SUPERVISOR         STUDENT     SUBJECT

                                                                   Functional characterization of the chemokine
             Project Presentation
                                    Viejo-Borbolla     Jürgens     enhancing activity of varicella zoster virus
15.04.2019                                                         glycoprotein C
                                                                   Identification of viral factors modulating neuronal
             Project Presentation   Viejo-Borbolla     Sun
                                                                   outgrowth and infection

                                                                   The role of interferon gamma in the control of
             Project Presentation   Kalinke            Mulenge
                                                                   herpes simplex virus-1 induced encephalitis
29.04.2019
                                                                   Molecular basis and early predictors of non-
             Project Presentation   Kalinke            Bruhn
                                                                   responsiveness to hepatitis B vaccination

                                                                   Microtubule motor binding of the large tegument
             Project Presentation   Sodeik             Cornelius
                                                                   protein pUL36 of Herpes-Simplex Virus
06.05.2019
                                                                   Dynamics of Herpes-Simplex Virus spread in skin
             Project Presentation   Sodeik             Richardo
                                                                   and to the peripheral nervous system

                                                                   Monitoring of human γδ T cell repertoires in
             Project Presentation
                                                                   healthy individuals and during chronic viral
                                    Ravens             Adriawan
                                                                   infections using next generation sequencing
13.05.2019
                                                                   technologies
             Project Presentation   Prinz              Binz        Investigating the specificity of γδ TCR

                                                                   Airway microbial metagenomics in health,
             Project Presentation   Tümmler            Pust
                                                                   bronchiectasis and COPD
20.05.2019
                                                                   Role of Salmonella invasion mechanisms for
             Project Presentation   Graßl              Alvarez
                                                                   disease development
35

DATE         FOCUS                  SUPERVISOR   STUDENT       SUBJECT

                                                               Characterisation of a novel small molecule
             Project Presentation
                                    Schulz       Tikla         inhibitor of Kaposi Sarcoma Herpesvirus
                                                               Replication
27.05.2019
                                                               Deep Sequencing of Human Cytomegalovirus
             Project Presentation
                                    Schulz       Götting       and Epstein-Barr Virus on the genome and
                                                               trancriptome level

                                                               Characterization and functional analysis of
             Project Presentation   Bernhardt    Abdulsemed
                                                               follicular T cells from wild type and mutant mice
03.06.2019                                                     2-Photon imaging of the immune response
             Project Presentation
                                    Halle        Zargari       following infection with murine
                                                               gammaherpesvirus 68 in vivo

                                                               Characterisation of the colitogenic candidate
             Project Presentation   Bleich       Villarreal
                                                               gene Alpk1 during infection
17.06.2019                                                     Mimicking intestinal microbiome using defined
             Project Presentation
                                    Bleich       Odum          bacterial consortia to define and modulate
                                                               disease paths in a susceptible host

                                                               Cure of chronic hepatitis C – Long-term effects
             Project Presentation   Cornberg     Kumaresan
                                                               on heterologous immune responses
24.06.2019
                                                               Investigations on the T cell response to skin
             Project Presentation   Werfel       Mikolajczyk
                                                               microbiota in atopic dermatitis

                                                               Interference of mouse cytomegalovirus M25
             Project Presentation   Messerle     Szymanska
                                                               proteins with the tumor suppressor protein p53
01.07.2019
             Topic Focus            n.n.
36
PhD Programs “Infection Biology / DEWIN”

                                                3rd Semester
   Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420

DATE         FOCUS                 SUPERVISOR           STUDENT              SUBJECT

                                                                             The CRISPR/Cas system and its
08.10.2018   Topic Focus           Bosnjak                                   potential in manipulating the immune
                                                                             system.

15.10.2018                    HBRS Opening: 17:00 - 19:00 hrs (Building J6, Level S0, Lecture Hall R)

             Topic                                      Kesthely             Post transcriptional modifications
22.10.2018                         Tümmler                                   Chen et al. 2018, Cell Reports: Genome-
             Original Paper                             Elsheikh             wide Translation Profiling by Ribosome-
                                                                             Bound tRNA Capture

                                                                             Initiating the gene expression program of
29.10.2018   Topic Focus           Kropp
                                                                             DNA viruses

05.11.2018   Topic Focus           Häußler                                   Bacterial Biofilms

                                                                             Cellular restriction factors interfering with
             Topic                                      Anagho
                                                                             HIV infection
12.11.2018                         Gerold                                    Besnard et al. 2016, Cell Host &
             Original Paper                             Freise               Microbe: The mTOR Complex Controls
                                                                             HIV Latency

                                                                             Common cellular entry pathways used by
             Topic                                      Kirui
                                                                             different virus families
19.11.2018                         Sodeik                                    Zhang et al. 2017, J Virol: West Nile
             Original Paper                             Möller               Virus NS1 Antagonizes Interferon Beta
                                                                             Production by Targeting RIG-I and MDA5

                                                                             Innate immune responses against
             Topic                                      Deseke
                                                                             infections
                                                                             Nadjsombati et al. 2018, Immunity,
26.11.2018                         Lochner
                                                                             Detection of Succinate by Intestinal Tuft
             Original Paper                             Ospina
                                                                             Cells Triggers a Type 2 Innate Immune
                                                                             Circuit

                                                                             Gut-Microbe Interactions in health and
             Topic                                      Elsheikh
                                                                             disease
03.12.2018                         Graßl                                     Donaldson et al. 2018, Science: Gut
             Original Paper                             Lanfermann           microbiota utilize immunoglobulin A for
                                                                             mucosal colonization
37

DATE         FOCUS            SUPERVISOR    STUDENT       SUBJECT

                                                          Maintenance of latency by alpha-
             Topic                          Freise
                                                          herpesviruses
10.12.2018                    Messerle                    Murer et al. 2018, PLOS Pathogens:
             Original Paper                 Passos        EBV persistence without its EBNA3A and
                                                          3C oncogenes in vivo

17.12.2018   Topic Focus      Klos                        Pathogens and complement

                                                          Role of cytotoxic T cells and NKs in
07.01.2019   Topic Focus      Halle
                                                          controlling virus infections.

                                                          The biology of gamma/delta T cells and
14.01.2019   Topic Focus      Ravens
                                                          their role in infection control

             Topic                          Ospina        B cell responses during infection
                                                          Tan et al., Nature Medicine, A public
21.01.2019                    Weiß
                                                          antibody lineage that potently inhibits
             Original Paper                 Deseke
                                                          malaria infection through dual binding to
                                                          circumsporozoite protein

                                                          Viral interference with the innate immune
             Topic                          Möller
                                                          response
28.01.2019                    Brinkmann                   Lauber et al. 2017, Cell Host & Microbe:
             Original Paper                 Anagho        Deciphering the Origin and Evolution of
                                                          Hepatitis B Viruses

                                                          Antiviral Inhibitors (mode of action,
             Topic                          Pietschmann   limitations in clinical use; focus on HIV
                                                          inhibitors)
04.02.2019                    Pietschmann
                                                          Zhang et al. 2018, Nature: Mxra8 is a
             Original Paper                 Kirui         receptor for multiple arthritogenic
                                                          alphaviruses

                                                          In vivo bacterial evolution and strain
             Topic                          Lanfermann
                                                          diversity
                              Valentin-
11.02.2019                                                Sela et al. 2018, PLoS Pathogens:
                              Weigand
             Original Paper                 Kesthely      Strains of bacterial species induce a
                                                          greatly acute adaptive immune response

18.02.2019   Topic Focus      Suwandi                     Gut-microbiota interaction

                                                          Pattern recognition receptors in innate
25.02.2019   Topic Focus      Becker
                                                          immune defense.
38
PhD Programs “Infection Biology / DEWIN”

                                              4th Semester
  Times & Location: Mondays, 16:30-18:00 hrs, MHH, TPFZ/I-11, Seminar Room S0-1420

DATE         FOCUS                  SUPERVISOR       STUDENT      SUBJECT

             Topic Focus            n.n
01.04.2019
             Topic Focus            n.n

                                                                  Targeting biofilm resistance
             Project Presentation   Häußler          Elsheikh
                                                                  mechanisms
08.04.2019
             Topic Focus            Häußler

                                                                  The role of TIM-1 and TSPAN9 in
             Project Presentation   Gerold           Kirui
                                                                  alphavirus host cell entry
15.04.2019
             Topic Focus            Gerold

                                                                  Immune mechanisms controlling latent
             Project Presentation   Förster          Ospina
                                                                  MCMV infections in mice
29.04.2019
             Topic Focus            Förster

                                                                  Harnessing cell-encoded factors to
             Project Presentation   von Hahn         Anagho       block replication of hepatitis D virus
06.05.2019                                                        (HDV)
             Topic Focus            von Hahn

                                                                  Functional characterization of
                                                                  Chlamydia trachomatis 166
             Project Presentation   Klos             Lanfermann   homologous effector proteins of C.
13.05.2019                                                        psittaci, C. muridarum and other
                                                                  chlamydia species
             Topic Focus            Klos

                                                                  In vivo study of the interaction of
             Project Presentation   Prinz            Deseke       dendritic cells and γδ T cells in skin
20.05.2019                                                        immunity, memory, and tolerance
             Topic Focus            Prinz
39

DATE          FOCUS                  SUPERVISOR   STUDENT    SUBJECT

                                                             Bacterial adaptation strategies to
              Project Presentation   Häußler      Kesthely
                                                             chronic biofilm-associated infections
27.05.2019
              Topic Focus            Häußler

                                                             Characterization of hepatitis C virus
              Project Presentation   Gerold       Möller
                                                             and arenaviruses co-infection
03.06.2019
              Topic Focus            Gerold

                                                             Regulation of Kaposi Sarcoma
              Project Presentation   Schulz       Freise     Herpesvirus Latency through
17.06.2019                                                   Interferon-Dependent Mechanisms
              Topic Focus            Schulz

              Topic Focus            n.n
24.06.2019
              Topic Focus            n.n

              Topic Focus            n.n
01.07.2019
              Topic Focus            n.n

Retreats:
November 14th, 2018 for the Class of 2017
February 26th, 2019 for the Class of 2016

Intermediate Exam for the Class of 2017:
March 27th, 2019

PhD Final Exams:
January 18th, 2019
June 28th, 2019
40
PhD Program “Regenerative Sciences”

Chairman of program committee:      Professor Ulrich Martin
Vice-chairwoman:                    PD Dr. Ina Gruh

Times (in general):
Tutorials        Thursday, 3.00 – 4.00 pm
Seminars         Thursday, 4.15 – 5.45 pm

30th May 2019 is Ascension Day (‘Christi Himmelfahrt’) which is a public holiday. Therefore, this week’s teaching is
shifted to 28th May 2019 (4th semester only).

Exceptions in day and time are printed in bold.

Locations (in general)
Semester 1 & 2 MHH, building I/J 04, level 01, HBRS seminar room 1140
Semester 3 & 4 MHH, building I/J 11, Hans-Borst-Zentrum (HBZ), level S0, seminar room 6040

Exceptions in location are marked **.
  1st semester

  Introductory lecture 1
                                                              Monday,
  Welcome address, the curriculum of         seminar                               12.30 –1.30 pm     Ulrich Martin
                                                              08.10.2018
  REBIRTH & HBRS, Q & A

  Introductory lecture 2
                                                              Monday,
  Principles of regenerative sciences and    seminar                               1.30 – 2.30 pm     Ulrich Martin
                                                              08.10.2018
  the REBIRTH approach

                                                              Thursday,
  Principles of growth factor                seminar                               4.15 – 5.45 pm     Rainer Niedenthal
                                                              18.10.2018
  signalling 1
  - Paracrine and juxtacrine signaling
  - Signalling pathways involved in the
                                                              Thursday,
    regulation of growth                     tutorial                              3.00 – 4.00 pm     Rainer Niedenthal
                                                              25.10.2018

                                                              Thursday,
                                             seminar                               4.15 – 5.45 pm     Michael Morgan
  Principles of growth factor                                 25.10.2018
  signalling 2
  Cytokines, hormones, and their
  receptors                                                   Thursday,
                                             tutorial                              3.00 – 4.00 pm     Michael Morgan
                                                              01.11.2018

                                                              Thursday,
                                             seminar                               4.15 – 5.45 pm     Siegfried Weiß
  Basic mechanisms of                                         01.11.2018
  inflammation 1
  Innate and adaptive immunity and
  differentiation                                             Thursday,
                                             tutorial                              3.00 – 4.00 pm     Siegfried Weiß
                                                              08.11.2018
41

                                                       Thursday,                     Ulrich Lehmann-
                                          seminar                   4.15 – 5.45 pm
                                                       08.11.2018                    Mühlenhoff
Basic mechanisms of
inflammation 2
Infection & cancer
                                                       Thursday,                     Ulrich Lehmann-
                                          tutorial                  3.00 – 4.00 pm
                                                       22.11.2018                    Mühlenhoff

Principles of developmental biology                    Thursday,
and organogenesis 1                       seminar *                 3.00 – 4.30 pm   Andreas Kispert
                                                       15.11.2018
- Commitment, differentiation,
  apoptosis, patterning
- Morphogenetic gradients and cell-cell
  communication                                        Thursday,
                                          tutorial *                4.45 – 5.45 pm   Andreas Kispert
- Genetic and epigenetic mechanisms
                                                       15.11.2018

Principles of developmental biology                    Thursday,
                                          seminar                   4.15 – 5.45 pm   Achim Gossler
and organogenesis 2                                    22.11.2018
- Model systems in developmental
  Biology
- Embryogenesis and fetal                              Thursday,
  development                             tutorial                  3.00 – 4.00 pm   Achim Gossler
                                                       06.12.2018

                                                       Thursday,
                                          seminar *                 3.00 – 4.30 pm   Thomas Müller
                                                       29.11.2018
Principles of stem cell biology 1
- Embryonic derivation of stem cells
- Culture methods
                                                       Thursday,
                                          tutorial *                4.45 – 5.45 pm   Thomas Müller
                                                       29.11.2018

                                                       Thursday,
                                          seminar                   4.15 – 5.45 pm   Amar Deep Sharma
Principles of stem cell biology 2                      06.12.2018
- Tumor stem cells and mechanisms of
  transformation
- Principles of cell cycle regulation                  Thursday,
                                          tutorial                  3.00 – 4.00 pm   Amar Deep Sharma
                                                       13.12.2018

                                                       Thursday,
                                          seminar                   4.15 – 5.45 pm   Gudrun Göhring
                                                       13.12.2018
Principles of chromosomal
instability
                                                       Thursday,
                                          tutorial                  3.00 – 4.00 pm   Gudrun Göhring
                                                       20.12.2018
42

                                                           Thursday,
                                           seminar                              4.15 – 5.45 pm    Anette Melk
                                                           20.12.2018
  Cellular senescence, tumor
  suppression and organismal aging
                                                           Thursday,
                                           tutorial                             3.00 – 4.00 pm    Anette Melk
                                                           10.01.2019

  Principles of cell engineering 1
  - MicroRNAs (miRNA) and downstream                       Thursday,
                                           seminar                              4.15 – 5.45 pm    Thomas Thum
    targets - technical approaches                         10.01.2019
  - Use of miRNA target identification
    software
  - Design of miRNA                                        Thursday,
  - Luciferase-gene reporter assays        tutorial                             3.00 – 4.00 pm    Jan Fiedler
                                                           17.01.2019
    (tutorial)

  Principles of cell engineering 2                         Thursday,
                                           seminar                              4.15 – 5.45 pm    Axel Schambach
  - Transient DNA delivery                                 17.01.2019
  - Episomal maintenance
  - Stable DNA delivery
  - Homologous recombination                               Thursday,
  - Site-specific DNA modification         tutorial                             3.00 – 4.00 pm    Axel Schambach
                                                           24.01.2019

                                                           Thursday,
                                           seminar                              4.15 – 5.45 pm    Dagmar Wirth
  Synthetic biology and options for                        24.01.2019
  regeneration
                                                           Thursday,
                                           tutorial                             3.00 – 4.00 pm    Dagmar Wirth
                                                           31.01.2019
                                                           Thursday,
  Principles of cell engineering 3         seminar *                            3.00 – 4.30 pm    Thomas Scheper
                                                           07.02.2019
  - Cell expansion
  - Bioreactors                                            Thursday,                              Thomas Scheper /
                                           tutorial * **                        4.45 – 5.45pm
                                                           07.02.2019                             Frank Stahl

Please note the following changes:

* The seminars on 15th and 29th November 2018 and 7th February 2019 will be immediately followed by the
associated tutorial.

** The tutorial (Thomas Scheper) on Thursday, 7th February 2019 will NOT take place at MHH but at the
Institute of Technical Chemistry
Leibniz Universität Hannover (LUH)
Callinstr. 3
30167 Hannover
Callinstr. 3 (LUH) can easily be reached by tram no. 4 directly from MHH to stop Schneiderberg/Wilhelm-Busch-
Museum (20 minutes tram)
43
PhD Program “Regenerative Sciences”
 2nd semester

 Principles of materials sciences for                        Thursday,
                                             seminar *                     3.00 – 4.30 pm   Annette Barchanski
 regenerative medicine 1                                     11.04.2019
 - Nanoparticles (NPs) in medicine
   (seminar)
 - Nano-manufacturing & nanoanalytics                        Thursday,
                                             tutorial * **                 4.45 – 5.45 pm   Annette Barchanski
   using lasers (tutorial)                                   11.04. 2019

 Principles of materials sciences for                        Thursday,
 regenerative medicine 2                     seminar *                     3.00 – 4.30 pm   Peter Behrens
                                                             18.04. 2019
 Introduction to biomaterials
 - Ceramic materials (seminar)                               Thursday,
 - Chemistry (tutorial)                      tutorial *                    4.45 – 5.45 pm   Peter Behrens
                                                             18.04. 2019

 Principles of materials sciences for                        Thursday,
 regenerative medicine 3                     seminar *                     3.00 – 4.30 pm   Birgit Glasmacher
                                                             25.04.2019
 - Polymeric and metallic materials
   (seminar)
 - Cell-biomaterial interactions (seminar)                   Thursday,
                                             tutorial *                    4.45 – 5.45 pm   Birgit Glasmacher
 - Scaffold technologies (tutorial)                          25.04.2019

                                                             Thursday,
 Principles of growth factor                 seminar *                     3.00 – 4.30 pm   Michael Morgan
                                                             02.05.2019
 engineering
 Engineering growth factors and their
 receptors for regenerative medicine                         Thursday,
                                             tutorial *                    4.45 – 5.45 pm   Michael Morgan
                                                             02.05.2019

 Laser technology in medicine 1                              Thursday,                      Alexander
                                             seminar *                     3.00 – 4.30 pm
 Imaging                                                     09.05.2019                     Heisterkamp
 - Basics of microscopy
 - Contrast mechanisms
 - Modern approaches in imaging                              Thursday,                      Alexander
                                             tutorial*                     4.45 – 5.45 pm
 - Superresolution microscopy                                09.05.2019                     Heisterkamp

 Laser technology in medicine 2                              Thursday,
                                             seminar *                     3.00 – 4.30 pm   Boris Chichkov
 Laser manipulation/machining                                16.05.2019
 - Surface treatment, structuring,
   polymerization
 - Laser-tissue interaction                                  Thursday,
                                             tutorial * **                 4.45 – 5.45 pm   Boris Chichkov
 - Laser manipulation of cells                               16.05.2019

                                                             Thursday,
                                             seminar                       4.15 – 5.45 pm   Achim Gossler
                                                             23.05.2019
 Animal models of human disease 1
 Murine models of human disease
                                                             Thursday,
                                             tutorial                      3.00 – 4.00 pm   Achim Gossler
                                                             06.06.2019

                                                             Thursday,
                                             seminar                       4.15 – 5.45 pm   Andres Hilfiker
 Cardiovascular tissue engineering:                          06.06.2019
 Principles
                                                             Thursday,
                                             tutorial                      3.00 – 4.00 pm   Andres Hilfiker
                                                             13.06.2019
44
                                                             Thursday,
                                              seminar                               4.15 – 5.45 pm      Axel Haverich et al.
  Principles of organ transplantation 1                      13.06.2019
  Heart, lung, and vessels                                   Thursday,
                                              tutorial                              3.00 – 4.00 pm      Axel Haverich et al.
                                                             20.06.2019

                                                             Thursday,
                                              seminar                               4.15 – 5.45 pm      Michael Ott
  Principles of organ transplantation 2                      20.06.2019
  Liver, pancreas, and ß-cells                               Thursday,
                                              tutorial                              3.00 – 4.00 pm      Michael Ott
                                                             27.06.2019

                                                             Tuesday,
  Stem cell based organ regeneration          seminar                               4.15 – 5.45 pm      Robert Zweigerdt
                                                             02.07.2019
  - Heart and ß-cells
  - clinical translation                                     Thursday,
                                              tutorial                              3.00 – 4.00 pm      Robert Zweigerdt
                                                             04.07.2019

                                                             Thursday,
  Animal models of human disease 2            seminar                               4.15 – 5.45 pm      Thomas Moritz
                                                             04.07.2019
  - Primate models
  - Humanized mouse models                                   Thursday,
                                              tutorial                              3.00 – 4.00 pm      Thomas Moritz
                                                             11.07.2019

  Animal models of human disease 3                           Thursday,
                                              seminar                               4.15 – 5.45 pm      Heiner Niemann
  - Transgenic pigs                                          11.07.2019
  - Xenotransplantation                                      Thursday,
  - Donor animal engineering                  tutorial                              3.00 – 4.00 pm      Heiner Niemann
                                                             18.07.2019

Please note the following changes
* The seminars on 11th, 18h, 25th April 2019 and 2nd, 9th, 16th May 2019 will be immediately followed by the
associated tutorial. The seminars and tutorials on 11th, 18th, 25th April 2019 and 9th, 16th May 2019 will NOT take
place at MHH, please find the respective addresses below.

** the following seminars require prior registration:
           Register until 4th April for the seminar on 11th April 2019 (Anette Barchanski)
           Register until 9th May for the seminar on 16th May 2019 (Boris Chichkov)
Please register with phd-regsci@mh-hannover.de, you may of course register for both seminars at the same time.
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