PROGRAM October 4-5, 2018 Beaumont Children's Royal Oak, Michigan - Midwest Society for Pediatric Research - Medpub

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PROGRAM October 4-5, 2018 Beaumont Children's Royal Oak, Michigan - Midwest Society for Pediatric Research - Medpub
Midwest Society for Pediatric Research
               PROGRAM
             October 4-5, 2018
              Beaumont Children's
              Royal Oak, Michigan

                  Co-Hosted by:

    Abstract Deadline: Friday, June 8, 2018

   Registration Deadline: September 21, 2018

                  Co-Hosted by:
PROGRAM October 4-5, 2018 Beaumont Children's Royal Oak, Michigan - Midwest Society for Pediatric Research - Medpub
PROGRAM‐AT‐A‐GLANCE

    59th Annual Midwest Society for Pediatric Research Scientific Meeting
                           Beaumont Children's
                  OUWB Auditorium, Beaumont Children's
                          Royal Oak, MI Meeting

       TIME                            ACTIVITY AND LOCATION
                                   WEDNESDAY, OCTOBER 3, 2018
 4:45 pm – 6:15 pm                     MWSPR Council Meeting
                         Beaumont, Royal Oak – John D. Labriola Conference Room
 6:30 pm – 9:30 pm                     MWSPR Council Dinner
                                            TBD, Royal Oak
                                    THURSDAY, OCTOBER 4, 2018
 7:00 am – 8:00 am                       MWSPR Registration
                             Beaumont, Royal Oak ‐ Administration Lobby
 7:00 am – 8:00 am                       Continental Breakfast
                               Beaumont, Royal Oak ‐ OUWB Classrooms
8:00 am – 11:45 am                    MWSPR Plenary Session I
                               Beaumont, Royal Oak ‐ OUWB Auditorium
11:45 am – 12:00 pm            MWSPR Business Meeting for Members
                               Beaumont, Royal Oak ‐ OUWB Auditorium
12:00 pm – 1:30 pm           Founder and Sutherland Award Luncheon
                               Beaumont, Royal Oak ‐ OUWB Classrooms
1:30 pm – 4:30 pm                     MWSPR Plenary Session II
                               Beaumont, Royal Oak ‐ OUWB Auditorium
 4:30 pm – 4:45 pm                           Poster Set‐up
                                    Beaumont, Royal Oak, Suite 100
 4:45 pm – 6:15 pm             Reception and Combined Poster Session
                                   Beaumont, Royal Oak ‐ Suite 100
     6:15 pm                              Poster Take Down
                                    (immediately following Session)
                                      FRIDAY, OCTOBER 5, 2018
 7:00 am – 8:00 am                       MWSPR Registration
                             Beaumont, Royal Oak ‐ Administration Lobby
7:00 am – 8:00 am                        Continental Breakfast
                               Beaumont, Royal Oak ‐ OUWB Classrooms
 7:00 am – 8:00 am                         Trainee Breakfast
                                 Professional Societies and Networking
                                             Brian Berman
                                            Chair, Pediatrics
                                          Beaumont Children’s
                               Beaumont, Royal Oak ‐ OUWB Auditorium
8:00 am – 12:00 pm                   MWSPR Plenary Session III
                               Beaumont, Royal Oak ‐ OUWB Auditorium
12:15 pm – 1:30 pm      Kenny, Metcoff, and Student Research Award Luncheon
                               Beaumont, Royal Oak ‐ OUWB Classrooms

                                       1
PROGRAM October 4-5, 2018 Beaumont Children's Royal Oak, Michigan - Midwest Society for Pediatric Research - Medpub
This meeting has been made possible in part through the generosity of our supporters and the
research efforts of the faculty, fellows, residents, medical and graduate students. We are very proud
of the extent and breadth of our research programs and activities, and we trust that you will enjoy
the activities of the meeting. We would like to thank the abstract reviewers for their time and effort
in the review process in this important endeavor.
Campus Map:

                                   MWSPR Planning Committee
                                  Laura Haneline, MD – President
                                Neal Blatt, MD, PhD – President‐Elect
                                    Carl Backes, MD – Secretary
                                   Noah Hillman, MD – Treasurer

                                     Acknowledgements
The Midwest Society for Pediatric Research would like to thank the following organizations for
their generous support:
                                         Abbott Nutrition
                                       Beaumont Children's
                                      Mead Johnson Nutrition

                                                  2
59th Annual Midwest Society for Pediatric Research Scientific Meeting

                                 THURSDAY, OCTOBER 4, 2018
                                     8:00 am – 6:00 pm

                          OUWB Auditorium, Beaumont Children's

7:00‐8:00 am REGISTRATION AND CONTINENTAL BREAKFAST

8:00‐8:05      WELCOME AND INTRODUCTION
               Laura Haneline, President

8:05     State‐of‐the‐Art Speaker
         CURRENT UPDATE ON FETAL SURGERY.
         Anthony Odibo, MD, MSCE, FRCOG, FACOG
         Professor, College of Medicine Obstetrics & Gynecology, University of South Florida

                                  MWSPR PLENARY SESSION I
                              OUWB Auditorium, Beaumont Children's

Presiding: Sarah Haskell and Steven Olsen

9:00   GENETIC DEFECTS IN SHROOM3 LEAD TO CONGENITAL HEART DEFECTS.
       M Durbin and SM Ware, Indianapolis, IN. Indiana University School of Medicine
                                                                                         Abstract 1

9:15   CARDIAC INJURY CAUSED BY SEPSIS IN A NEONATAL MOUSE MODEL.
       A Rajgarhia, H Menden, S Mabry, A Kats, and V Sampath, Kansas City, MO. Children's Mercy,
       Kansas City ‐ UMKC School of Medicine                                        Abstract 2

9:30   TARGETING RIBONUCLEOTIDE REDUCTASE AND PROTEIN SYNTHESIS IN EWING
       SARCOMA TUMORS.
       DJ Gordon, SL Koppenhafer, KL Goss, and WW Terry, Iowa City, IA. University of Iowa
                                                                                     Abstract 3

9:45   ALTERED FETAL ISLET TRANSCRIPTOME PREDICTS ISLET DYSFUNCTION IN
       OFFSPRING EXPOSED TO IN‐UTERO HYPERGLYCEMIA.
       K Kua and JJ Casasnovas, Indianapolis, IN. Indiana University School of Medicine
                                                                                       Abstract 4

                                     10:00 – 10:15 am BREAK

Presiding: David McCulley and Sara Ramel

10:15 OUTCOMES FOLLOWING TWO DIFFERENT TREATMENT APPROACHES (PROACTIVE
      VERSUS SELECTIVE) FOR INFANTS BORN AT 22 WEEKS OF GESTATION.
      C Mitchell, L Walsh, C Backes, F Soderstrom, J Agren, R Sindelar, C Bartlett, B Rivera, J Iams,
      H Frey, J Richter, E Shepherd, L Nelin, and E Normann, Columbus, OH and Uppsala, Sweden.
      Nationwide Children's Hospital/The Ohio State University                           Abstract 5

                                                  3
10:30 ELEVATED CIRCULATING NEUTROPHIL‐LYMPHOCYTE RATIOS IDENTIFY PRETERM
      NEONATES EXPOSED TO HISTOLOGIC CHORIOAMNIONITIS AND EARLY‐ONSET
      SEPSIS.
      A Singareddy, PL Sweeney, A Lee, P Buchanan, HJ Williams, NJ Hillman, and JM Koenig, Saint
      Louis, MO and Memphis, TN. Saint Louis University                             Abstract 6

10:45 CARDIOMETABOLIC CONSEQUENCES AFTER EXPOSURE TO EXCESS PRENATAL FUELS.
      EJ Louwagie, TD Larsen, and ML Baack, Sioux Falls, SD. University of South Dakota
                                                                                     Abstract 7

11:00 A RETROSPECTIVE SEGMENTATION ANALYSIS OF PLACENTAL VOLUME BY MAGNETIC
      RESONANCE IMAGING FROM FIRST TRIMESTER TO TERM GESTATION.
      RL Leon and BP Brown, Indianapolis, IN. Indiana University School of Medicine
                                                                                    Abstract 8

11:15 PLACENTAL TRANSFUSION IMPLEMENTAION AND OUTCOMES: A SINGLE CENTER
      EXPERIENCE 2010‐2016.
      C Njinimbam, F Soltys, and WA Engle, Indianapolis, IN. Indiana University School of Medicine
                                                                                     Abstract 9

11:30 A GENETIC MODEL OF DIAPHRAGMATIC HERNIA, LUNG HYPOPLASIA, AND
      PULMONARY HYPERTENSION.
      DJ McCulley, M Brix, H Bremer, G Stokes, Y Shen, and W Chung, Madison, WI and New York,
      NY. University of Wisconsin – Madison                                       Abstract 10

11:45 MWSPR BUSINESS MEETING FOR NON‐TRAINEES

12:00 FOUNDER AND SUTHERLAND AWARD LUNCHEON
      Beaumont, Royal Oak ‐ OUWB Classrooms

                                 Founder Award Recipient
                                        Scott C. Denne, MD
                               Indiana University School of Medicine
                             Introduction by: Edward A. Liechty, MD

                                  MWSPR PLENARY SESSION II
Presiding: Lyndsey Harshman and Steven McElroy

1:30   ABNORMAL DIASTOLIC BLOOD PRESSURE TRENDS IN VERY LOW BIRTH WEIGHT
       INFANTS FOLLOWING ACUTE KIDNEY INJURY.
       K Kellner, A Pham, A Schwartz, and N Srinivasan, Chicago, IL. University of Illinois
                                                                                        Abstract 11

1:45   TRANSCATHETER PATENT DUCTUS ARTERIOSUS (PDA) CLOSURE IN LOWER WEIGHT
       INFANTS (
2:00   ADRENOCORTICOTROPIC HORMONE STIMULATES VASCULAR ENDOTHELIAL
       GROWTH FACTOR RELEASE IN HEALTHY CHILDREN AND ADOLESCENTS.
       RA Heksch and RP Hoffman, Columbus, OH. Nationwide Children's Hospital
                                                                              Abstract 13

2:15   NITRIC OXIDE DONOR INCREASES PDE3A PROTEIN EXPRESSION IN HUMAN
       PULMONARY ARTERY SMOOTH MUSCLE CELLS.
       JA Dillard, X Meng, and B Chen, Columbus, OH. Nationwide Children’s Hospital/The Ohio
       State University                                                           Abstract 14

2:45   THE EXPRESSION OF THE ERBB FAMILY IN HUMAN PULMONARY MICROVASCULAR
       ENDOTHELIAL CELLS.
       CS Regan, Y Jin, C Pool, Y Liu, B Chen, and LD Nelin, Dublin, OH and Columbus, OH.
       Nationwide Children's Hospital/The Ohio State University                       Abstract 15

                                     3:00 – 3:15 pm BREAK

3:15   HIGH OSMOLALITY FORMULA INDUCES INTESTINAL INJURY AND MICROBIOME
       SHIFTS SIMILAR TO NEC.
       SR Lueschow, S Kern, H Gong, and SJ McElroy, Elmwood, IL and Iowa City, IA. University of
       Iowa                                                                        Abstract 16

3:30   NOVEL SIGIRR TRANSGENIC MICE ENCODING MUTATION FOUND IN HUMAN NEC HAVE
       DECREASED INTESTINAL EXPRESSION OF THE MICRORNAS MIR146A AND MIR155
       AND INCREASED INFLAMMATION.
       W Yu, HW Menden, SW Xia, A Cuna, and V Sampath, Kansas City, MO. Children's Mercy
       Hospital                                                                 Abstract 17

3:45   THE METABOLOMICS OF NECROTIZING ENTEROCOLITIS: INFLAMMATORY AND
       TRYPTOPHAN METABOLISM PATHWAY DYSREGULATION AND BIOMARKER
       DEVELOPMENT.
       CA Sibbald, MM Goree, WE Lanik, B Mihi, Q Gong, ML Mara, and M Good, St. Louis, MO.
       Washington University in St. Louis                                         Abstract 18

4:00   HUMAN CATHELICIDIN LL‐37 SIGNIFICANTLY DECREASES INTESTINAL INJURY
       SCORES IN EXPERIMENTAL NECROTIZING ENTEROCOLITIS.
       JN Berger, H Gong, and SJ McElroy, Iowa City, IA. University of Iowa Abstract 19

4:15   PANETH CELL DEVELOPMENT STARTS AFTER LIMITS OF VIABILITY.
       AH Stanford, H Gong, MA Mara, WE Lanik, Q Gong, M Good, and SJ McElroy, Iowa City, IA and
       St Louis, MO. University of Iowa                                          Abstract 20

4:30   RECEPTION AND COMBINED POSTER SESSION – Beaumont, Royal Oak ‐ Suite 100

                                     See page 8 for posters

                                                5
FRIDAY, OCTOBER 5, 2018
                          OUWB Auditorium ‐ Beaumont Children's

                                      7:00 am – 1:30 pm

7:00   MWSPR REGISTRATION
7:00   TRAINEE BREAKFAST SESSION

                           Professional Societies and Networking
                                     Brian Berman, MD
                                      Chair, Pediatrics
                                    Beaumont Children’s
                           Beaumont, Royal Oak ‐ OUWB Classrooms

                                 MWSPR PLENARY SESSION III
                                    8:00 am – 12:00 pm

Presiding: Craig Garfield and Ben Kopp

8:00   State‐of‐the‐Art Speaker
       50 Years PERSPECTIVE ON THE TREATMENT OF BABIES WITH JAUNDICE.
       M. Jeffrey Maisels, MD
       Professor, Department of Pediatrics
       Oakland University William Beaumont School of Medicine

9:00   EXOME SEQUENCING IDENTIFIES STAB2 DEFICIENCY AS A GENETIC RISK FOR VENOUS
       THROMBOEMBOLIC DISEASE.
       KC Desch, AB Ozel, and D Ginsburg, Ann Arbor, MI. University of Michigan Abstract 21

9:15   INTRAPLEURAL ADMINISTRATION OF TISSUE PLASMINOGEN ACTIVATOR AND
       DORNASE ALFA IN PEDIATRIC PATIENTS WITH EMPYEMA.
       V Rajanna, JC Chan, PB Khandhar, and NM Novotny, Beverly Hills, MI, Rochester, MI, and
       Royal Oak, MI. Oakland University William Beaumont School of Medicine      Abstract 22

9:30   DYNAMIC REGULATION OF VESICULAR TRAFFICKING BY ALTERED STEROL
       HOMEOSTASIS: IMPLICATIONS FOR CHOLESTEROL SYNTHESIS DISORDERS.
       EH Anderson, JG Kerkvliet, AD Hoppe, and KR Francis, Sioux Falls, SD and Brookings, SD.
       Sanford School of Medicine‐University of South Dakota                        Abstract 23

9:45   USING ACCESSORY GENOMIC ELEMENTS OF PSEUDOMONAS AERUGINOSA TO
       PREDICT ERADICATION FOLLOWING NEW INFECTION IN CYSTIC FIBROSIS.
       M Soneji, E Ozer, M Kandpal, N Mayer‐Hamblett, PK Singh, and AR Hauser, Chicago, IL and
       Seattle, WA. Northwestern University                                       Abstract 24

                                   10:00 – 10:15 am BREAK

                                                6
Presiding: Ulrike Mietzsch and Noah Hillman

10:15 INTERACTIONS BETWEEN ANGIOTENSIN RECEPTORS, TRANSFERRIN RECEPTORS,
      AND MULTI‐LIGAND RECEPTORS IN GROWTH RESTRICTED FETAL KIDNEYS.
      HA Prosek, AS Bauer, SE Blohowiak, BR Pattnaik, and PJ Kling, Madison, WI. University of
      Wisconsin‐Madison                                                           Abstract 25

10:30 ROLE OF ERYTHROPOIETIN IN ACUTE KIDNEY INJURY IN NEONATAL RATS.
      KM Trieglaff, MW Harer, SE Blohowiak, and PJ Kling, Madison, WI. University of Wisconsin‐
      Madison                                                                      Abstract 26

10:45 ACTIVE HYPOTHERMIA DURING TRANSPORT REDUCES TIME TO TREATMENT IN
      NEONATES WITH HIE.
      KE Krause, RL Leon, RA Shope, EA Strait, MB Koch, and U Mietzsch, Indianapolis, IN. Indiana
      University School of Medicine                                               Abstract 27

11:00 ULTRASOUND ASSESSMENT OF BODY COMPOSITION IN THE NEONATAL INTENSIVE
      CARE UNIT.
      M Hickey, E Nagel, L Teigen, E Demerath, C Earthman, T Holm, and S Ramel, Minneapolis,
      MN. University of Minnesota                                                 Abstract 28

11:15 RELATIONSHIPS OF NUTRITION AND ILLNESS IN THE FIRST WEEK OF LIFE TO BODY
      COMPOSITION AT HOSPITAL DISCHARGE IN VERY LOW BIRTH WEIGHT PRETERM
      INFANTS.
      SE Ramel, J Haapala, and EW Demerath, Shoreview, MN and Minneapolis, MN. University of
      Minnesota                                                                Abstract 29

11:30 DUAL SPECIFICITY PHOSPHATASE‐1 DEFICIENCY STRENGTHENS IMMUNE DEFENSE
      AGAINST FUNGAL INFECTION.
      MM Talavera, S Crowell, T Juan, V Kim, LD Nelin, J Zhang, and Y Liu, Dublin, OH and
      Columbus, OH. Nationwide Children's Hospital                                   Abstract 30

11:45 NEONATES ARE UNIQUELY SUSCEPTIBLE TO ESCHERICHIA COLI K1 SEPSIS DUE TO
      EXCESS IRON.
      JR Bermick, K Michels, N Lambrecht, W Carson, S Kunkel, M Schaller, and N Lukacs, Ann
      Arbor, MI. University of Michigan                                           Abstract 31

12:15 pm – 1:30 pm MWSPR Kenny, Metcoff, and Student Research Award Luncheon
                    Sponsored by Abbott Nutrition
                    Beaumont, Royal Oak ‐ OUWB Classrooms

                                                7
RECEPTION AND COMBINED POSTER SESSION
                               THURSDAY, OCTOBER 4, 2018
                                Beaumont, Royal Oak ‐ Suite 100

Poster                                                                            Abstract
Number                                                                            Number
1      GABAPENTIN USE FOR HOSPITALIZED NEONATES.
       HH Abdi, NL Maitre, KL Benninger, ME Hester, and JL Slaughter, Columbus, OH. Nationwide
       Children's Hospital/The Ohio State University                              Abstract 32

2      NOVEL METHOD OF OXYTOCIN EXTRACTION IN HUMAN PLASMA.
       CO Adegboro, NW York, PJ Kling, and BR Pattnaik, Madison, WI. University of Madison‐
       Wisconsin                                                                    Abstract 33

3      UNDERSTANDING PREECLAMPSIA THROUGH COMBINATON DOSING OF ANGIOGENIC
       FACTORS ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS.
       D Adu and DS Boeldt, Madison, WI. University of Wisconsin‐Madison Abstract 34

4      SOUND IN THE NICU: IS A SINGLE ROOM THE ANSWER?
       D Aggarwal, D Rao, and S Chawla, Detroit, MI and Troy, MI. Wayne State University School of
       Medicine                                                                    Abstract 35

5      IMAGING FOR PEDIATRIC BLUNT ABDOMINAL TRAUMA ‐ DIFFERENT PREDICTION
       RULES, IS THE OUTCOME THE SAME?
       TS Ahn, A Ozcan, and M Menoch, Berkley, MI and Royal Oak, MI. Beaumont Children's
       Hospital                                                                  Abstract 36

6      CHILDREN WITH COMPLEX FEBRILE SEIZURES: IS HOSPITAL ADMISSION NECESSARY?
       MC Aldana, B Webb, M Naqvi, R Batshon, C Agu, U Sethuraman, and N Kannikeswaran,
       Dearborn, MI and Detroit, MI. Children's Hospital of Michigan            Abstract 37

7      PLACENTAL PATHOLOGY AND ASSOCIATION WITH PATTERN OF BRAIN INJURY ON
       MAGNETIC RESONANCE IMAGING IN PATIENTS TREATED WITH THERAPEUTIC
       HYPOTHERMIA FOR HYPOXIC ISCHEMIC ENCEPHALOPATHY.
       M Aye, P Agarwal, D Altinok, F Qureshi, S Jacques, A Farooqi, and S Shankaran, Detroit, MI.
       Children's Hospital of Michigan                                                Abstract 38

8      MR IMAGING ASSESSMENT TOOL FOR WHITE MATTER INJURY AFTER DEEP
       MEDULLARY VEIN THROMBOSIS AND INFARCTION IN NEONATES.
       KL Benninger, NL Maitre, L Ruess, and JA Rusin, Columbus, OH. Nationwide Children's
       Hospital/Ohio State University                                             Abstract 39

9      DELAYED PANETH CELL DEVELOPMENT WITH HEREGULIN‐1 IN IMMATURE MICE.
       JN Berger, H Gong, MR Frey, and SJ McElroy, Iowa City, IA and Los Angeles, CA. University of
       Iowa                                                                          Abstract 40

10     SURIVIVAL AND SHORT TERM RESPIRATORY OUTCOMES OF
11   DECREASED ANTIBIOTIC USE IN WELL‐APPEARING INFANTS EXPOSED TO MATERNAL
     CHORIOAMNIONITIS.
     LE Cummings, C Miner, LB Churchman, G Akangire, J Weiner, and J Jackson, Kansas City, MO
     and Shawnee Mission, KS. Children's Mercy Hospital                         Abstract 42

12   PRIMARY BURKITT LYMPHOMA IN A CHILD WITH DOWN SYNDROME.
     I Datta, S Roy, JW Taub, and S Savasan, Northville, MI and Detroit, MI. Wayne State
     University/Children's Hospital of Michigan                                    Abstract 43

13   EARLY FINDINGS OF MYOCARDIAL FIBROSIS ON CARDIAC MRI IN A 9 YEAR OLD
     FEMALE WITH LIMB GIRDLE MUSCULAR DYSTROPHY TYPE 2C.
     A Dupont, I Gonzalez, E McCormick and A Bilolikar, Royal Oak, MI. Beaumont Children's
                                                                                 Abstract 44

14   AN INFANT WITH CARDIAC VALVULAR PROBLEMS AND RESPIRATORY DISTRESS: THE
     HEART MAY NOT BE THE CULPRIT.
     A Dupont, and A Prabhu, Royal Oak, MI. Beaumont Children's Abstract 45

15   THE EFFECT OF STATEWIDE ELECTRONIC REPORTING ON PULSE OXIMETRY
     SCREENING IN NEWBORNS.
     MS Engel, A Phimister, A Gaviglio, L Spector, and JL Lohr, Plymouth, MN, Minneapolis, MN,
     and St. Paul, MN. University of Minnesota                                    Abstract 46

16   OFFSPRING OUTCOMES IN PREGNANCIES COMPLICATED BY MATERNAL CONGENITAL
     HEART DISEASES: A SYSTEMATIC REVIEW AND META‐ANALYSIS OF OBSERVATIONAL
     STUDIES.
     MD Essien, LV Ghimire, C Chen, and F Chou, Kansas City, KS and Laconia, NH. University of
     Kansas Medical Center                                                        Abstract 47

17   MEAN PLATELET VOLUME MAY BE USED TO GUIDE ANTIBIOTICS USE IN NEWBORNS
     WITH THROMBOCYTOPENIA AND LEUKOPENIA.
     MD Essien, C Chen, and F Chou, Kansas City, KS. University of Kansas Medical Center
                                                                                   Abstract 48

18   WEIGHT GAIN DURING PREGNANCY, CHILD BMI AND INFLAMMATION AT ONE YEAR
     OF AGE.
     J Gannon, AJ Pollock, SE Blohowiak, and DB Allen, Madison, WI. University of Wisconsin‐
     Madison                                                                       Abstract 49

19   EFFECTS OF GENETIC MUTATIONS ON THE RISK FOR NEONATAL COMPLICATIONS.
     KM Gnona, WC Stewart, P White, M Klebanoff, and I Buhimschi, Columbus, OH.
     Nationwide Children’s Hospital                                        Abstract 50

20   RESPIRATORY SYNCYTIAL VIRUS: MORE THAN JUST BRONCHIOLITIS.
     R Greene, DR Gurkha, N El‐Wiher, and AS Prabhu, Royal Oak, MI. Beaumont Children's
                                                                               Abstract 51
21   UTILITY OF PREOPERATIVE CRANIAL AND ABDOMINAL IMGAING IN CONGENITAL
     HEART DISEASE INFANTS.
     V Gunasekaran, G Natarajan, and S Aggarwal, Detroit, MI. Wayne State University
                                                                                 Abstract 52

                                              9
22   A 4 YEAR OLD CHILD WITH VIRAL MYOCARDITIS.
     A Gupta, T Eckenswiller and D Nguyen, Royal Oak, MI. Beaumont Children's     Abstract 53

23   ORGANOAXIAL GASTRIC VOVULUS IN A HEALTHY CHILD.
     GK Jones, B Akay and L Adams, Royal Oak, MI. Beaumont Children's             Abstract 54

24   BETA‐PROPELLER PROTEIN‐ASSOCIATED NEURODEGENERATION (BPAN) DETECTED
     IN A CHILD WITH EPILEPTIC SPASMS.
     G Kaleka, A Krishnan, and ME McCormick, Royal Oak, MI. Beaumont Children's
                                                                               Abstract 55

25   PREPUBESCENT PEDIATRIC PATIENT WITH PNEUMOTHORAX IN DIABETIC
     KETOACIDOSIS.
     G Kennady and P Khandhar, Royal Oak, MI. Beaumont Children's Abstract 56

26   SAN LUIS VALLEY SYNDROME IN A NON HISPANIC PATIENT ‐ A CASE REPORT WITH
     NEUROIMAGING FINDINGS.
     G Kennady, A Krishnan, and ME McCormick, Royal Oak, MI. Beaumont Children's
                                                                              Abstract 57

27   ATYPICAL PRESENTATION OF MICROSCOPIC POLYANGIITIS IN A YOUNG MAN WITH
     SHUNTED CONGENITAL HYDROCEPHALUS.
     J Kim, J Shah, and K Cashen, Detroit, MI. Wayne State University Abstract 58

28   PEDIATRIC RESIDENCY GRADUATE PREPAREDNESS FOR NEONATAL‐PERINATAL
     MEDICINE FELLOWSHIP: THE PERSPECTIVE OF FIRST YEAR FELLOWS.
     LJ Korbel, CH Backes, B Rivera, C Mitchell, M Carbajal, KM Reber, and EM Bonachea,
     Columbus, OH and Houston, TX. Nationwide Children's Hospital/The Ohio State University
                                                                                  Abstract 59

29   AN INDIVIDUAL HEALTH PLAN FOR CHILDREN WITH MEDICAL COMPLEXITY ‐ AN
     ASSESSMENT OF CAREGIVER EXPERIENCES.
     J Lammert, A Zabih, A Tanios, D Halloran, S Stricklin, and P Buchanan, Brentwood, MO, St.
     Louis, MO, and Columbia, MO. Saint Louis University                          Abstract 60

30   INCIDENCE AND ETIOLOGY OF EXTREME THROMBOCYTOPENIA IN A NEONATAL
     POPULATION.
     TJ LaRouere and B Berman, Royal Oak, MI. Children's Hospital of Michigan Abstract 61

31   UNDERSTANDING PARENTS’ INFORMATIONAL NEEDS IN THE PEDIATRIC INTENSIVE
     CARE UNIT.
     NM Laudato, L Yagiela, and KL Meert, Detroit, MI. Wayne State University Abstract 62

32   OPTIMAL TIMING OF HYPOTHYROIDISM NEWBORN SCREENS IN VERY LOW
     BIRTHWEIGHT (VLBW) NEONATES.
     S Levin, G Chan, A Molefe, and S Amin, Maywood, IL. Loyola University Medical Center
                                                                                  Abstract 63

33   WEETOS: EDIBLE CANNABINOIDS AND A CHILD WITH LETHARGY.
     J Lim, M Steck and P Khandhar, Royal Oak, MI. Beaumont Children's            Abstract 64

                                             10
34   USE OF NEURALLY ADJUSTED VENTILATORY ASSIST IN INFANTS WITH CONGENITAL
     DIAPHRAGMATIC HERNIA.
     RD Meinen, Y Alali, A Al‐Subu, M Wilhelm, R McAdams, D McCulley, and J Limjoco,
     McFarland, WI and Madison, WI. University of Wisconsin‐Madison              Abstract 65

35   A RISK‐PREDICTIVE MODEL FOR THE DEVELOPMENT OF RETINOPATHY OF
     PREMATURITY USING BIRTH WEIGHT, GESTATIONAL AGE, AND NEWBORN
     SCREENING METABOLITES.
     AT Morgan‐Harris, EA Jasper, SP Oltman, RJ Baer, EE Rogers, JM Dagle, LL Jelliffe‐Pawlowski,
     and KK Ryckman, Iowa City, IA and San Francisco, CA. University of Iowa Hospitals and
     Clinics                                                                        Abstract 66

36   A RIDE OF YOUR LIFE: SPONTANEOUS PNEUMOMEDIASTINUM IN AN ADOLESCENT
     FROM A ROLLER COASTER RIDE.
     D Nolan, and P Khandhar, Royal Oak, MI. Beaumont Children's Abstract 67

37   PERFORATED MECKEL’S DIVERTICULUM IN A NEONATE: CASE REPORT AND
     LITERATURE REVIEW.
     FO Orelaru, NS Reddy, and P Brahmamdam, Royal Oak, MI. Beaumont Children's
                                                                             Abstract 68

38   A 2 YEAR OLD CHILD WITH ECZEMA HERPETICUM.
     A Ozcan, K Kahale and D Nguyen, Royal Oak, MI. Beaumont Children's           Abstract 69

39   SUDDEN ARM SWELLING IN A NEONATE.
     LR Pavlek, and E Braswell, Hilliard, OH and Columbus, OH. Nationwide Children's Hospital
                                                                                 Abstract 70

40   A TEENAGER WITH SEVERE ANXIETY AND CHRONIC FECAL INCONTINENCE.
     A Porto, I Onwuzurike, K Levasseur, and M Menoch, Royal Oak, MI. Beaumont Children's
                                                                               Abstract 71

41   NOT JUST A DELTA WAVE: AN UNCOMMON DIAGNOSIS IN A PATIENT WITH WPW AND
     NEUROLOGIC EVENTS.
     A Prabhu, ME McCormick, and P Khandhar, Royal Oak, MI. Beaumont Children's
                                                                             Abstract 72

42   ROTAVIRUS VACCINATION AMONG NEONATES IN THE NEONATAL INTENSIVE CARE
     UNIT, HOW MANY ARE MISSED?
     CS Regan and PJ Sanchez, Dublin, OH and Columbus, OH. Nationwide Children's
     Hospital/The Ohio State University                                       Abstract 73

43   VENTILATOR ASSOCIATED EVENTS IN THE NEONATAL INTENSIVE CARE UNIT: A
     DESCRIPTIVE COHORT, LESSONS LEARNED, AND OPPORTUNITIES FOR PREVENTION.
     KM Satrom, J Cramer, E Tinjum, D Brown, and S Gupta, Saint Paul, MN and Minneapolis, MN.
     University of Minnesota                                                    Abstract 74
44   PROPOFOL‐ASSOCIATED PRIAPISM IN A PREPUBESCENT PEDIATRIC PATIENT.
     C Savoie, V Rajanna and P Khandhar, Royal Oak, MI. Beaumont Children's     Abstract 75

                                              11
45   MINIMIZING LENGTH OF STAY IN HOSPITALIZATIONS FOR WELL APPEARING FEBRILE
     INFANTS.
     SE Sefcovic, S Smith, and M Mier, Chicago, IL. University of Illinois at Chicago Abstract 76

46   SURFACTANT FOR ACUTE PULMONARY HEMORRAGE IN A NEONATE.
     HN Shah, K Rosburg, E Anderson, J Jones, and E Bonachea, Gahanna, OH and Columbus, OH.
     Nationwide Children's Hospital/The Ohio State University                  Abstract 77

47   WHAT ROLE SHOULD SOCIAL MEDIA PLAY IN CLINICAL DECISION MAKING?
     HN Shah, Gahanna. Nationwide Children's Hospital/The Ohio State University
                                                                                Abstract 78

48   MATERNAL TRANSFERS IMPACT NEONATAL MORTALITY IN VERY PRETERM
     INFANTS.
     K Shah, RO deRegnier, and AC Bennett, Chicago, IL. Northwestern University Medical Center
                                                                                 Abstract 79

49   VARIABILITY IN DIAGNOSTIC FLUOROSCOPY EVALUATION OF BOWEL OBSTRUCTION
     IN HOSPITALIZED INFANTS.
     ZS Shah, M Moallem, BD Kenney, DG Bates, and IK Gulati, Powell, OH and Columbus, OH.
     Nationwide Children's Hospital/The Ohio State University                   Abstract 80

50   VITAMIN D SCREENING IN CHILDREN & YOUNG ADULTS ‐ WHAT ARE WE DOING &
     WHAT SHOULD WE BE DOING?
     B Shannon, A Sawni, and J LaChance, Bloomfield Hills, MI and Flint, MI. Michigan State
     University                                                                    Abstract 81

51   A 4 YEAR OLD CHILD WITH TENSION PNEUMOPERITONEUM.
     S Sonnamaker, A Porto and D Nguyen, Royal Oak, MI. Beaumont Children's
                                                                                   Abstract 82

52   HISTOLOGICAL CHANGES OF BRONCHOPULMONARY DYSPLASIA AND PULMONARY
     HYPERTENSION: AN AUTOPSY SERIES OF 42 PRETERM INFANTS.
     A Stone, J Poulik, Y Xin, A Sharma, and BG Sood, Detroit, MI. Wayne State University
                                                                                    Abstract 83

53   NUP155 REGULATES PLURIPOTENT MICRORNA EXPRESSION.
     EC Storm, CC Preston, TA Bradley, and RS Faustino, Sioux Falls, SD. University of South
     Dakota                                                                         Abstract 84

54   THE INTESTINAL MICROBIOME OF THE LATE PRETERM INFANT IS ALTERED BY DIET
     AND ANTIBIOTIC USE.
     RA Vo, J White, Z Wang, X Wang, and S Marzano, Sioux Falls, SD and Brookings, SD.
     University of South Dakota                                                  Abstract 85

55   PRIMARY PULMONARY VEIN STENOSIS.
     L Walsh, B Rivera, C Mitchell, and C Backes, Columbus, OH. Nationwide Children's
     Hospital/The Ohio State University                                           Abstract 86

                                              12
56   MORAXELLA LACUNATA BACTEREMIA IN A TODDLER WITH ATYPICAL HEMOLYTIC
     UREMIC SYNDROME TREATED WITH ECULIZUMAB: CASE REPORT AND LITERATURE
     REVIEW.
     P Bicoll, A Goyal, NB Blatt, and BJ Freij, Royal Oak, MI. Beaumont Children's
                                                                                   Abstract 87

57   CHRONIC TESTICULAR TORSION IN A HEALTHY NEONATE.
     A Goyal and S Bassel, Royal Oak, MI. Beaumont Children's                    Abstract 88

58   PRENATAL DIAGNOSIS OF SMA WITH SUCCESSFUL INITIATION OF INTRA‐THECAL
     NUSINERSEN INDUCTION ON DAY 3 OF LIFE.
     E Son, G Kennady, and ME McCormick, Royal Oak, MI. Beaumont Children's
                                                                            Abstract 89

                                             13
The James Sutherland Award
        The James Sutherland Award was named after a neonatologist from the University of
Cincinnati, who was instrumental in establishing their neonatal unit. Dr. Sutherland was a
renowned teacher, clinical investigator, and role model for trainees. He was active in the Midwest
Society for Pediatric Research, and encouraged trainees to submit work at the annual meeting.
The award, which recognizes the best investigative work presented by a junior faculty member,
was first given in 1991. To be eligible for this award, the junior faculty candidate must be no more
than five years out of fellowship training.

       The award is accompanied by an honorarium and plaque. The recipient is announced and
honored each year at the Founder and Sutherland Awards Luncheon held during the MWSPR
annual meeting.

                       1994           Thomas Scholz, MD
                       1995           Edward N. Guillery, MD
                       1996           Michael R. Uhing, MD
                       1997           Carol Gilmour, MD
                       1998           Robert H. Lane, MD
                       1999           I. I. Ekekezie, MD
                       2000           D. Balkundi, MD
                       2001           Janine Y. Khan, MD
                       2002           Steven Pipe, MD
                       2003           Shruti M. Phadke, MD
                       2004           J. Carter Ralphe, MD
                       2005           Michael Blake, MD, PhD
                       2006           Matthew I. Goldsmith, MD
                       2007           Jayme D. Allen, MD
                       2008           Alex Huang, MD and Mara Becker, MD, MSCE
                       2009           Michael Wilhelm, MD
                       2010           Celeste Morely, MD
                       2011           Amy VanMorlan, MD
                       2012           Juan Boriosi, MD
                       2013           Craig A. Byersdorfer, MD
                       2014           Naim Alkouri, MD
                       2015           Sarah Haskell, MD
                       2016           Dave McCulley, MD
                       2017           Jennifer Bermick, MD and David Gordon, MD
                       2018           Awarded at the MWSPR Meeting

                                                 14
The Frederic M. Kenny Memorial Award

        Frederic M. Kenny was instrumental in establishing the Pediatric Endocrinology Clinical
and Fellowship Program at the Children’s Hospital in Pittsburgh. Dr. Kenny was a scholarship
student at Princeton University, then a medical school student at The Johns Hopkins University
School of Medicine, where he received his medical degree in 1955. He completed his general
pediatric residency at The Johns Hopkins Hospital in 1958 and then spent two years in the U.S.
Navy. He then returned to The Johns Hopkins Hospital where he completed a pediatric
endocrine fellowship.

        In 1962, Dr. Kenny accepted an invitation to move to Pittsburgh and assume the position
of director of the Pediatric Endocrine Division. He developed an outstanding clinical program in
pediatric endocrinology and laboratory research focused primarily on normal adrenal function
ranges for children and adolescents. He was intensely interested in the pathophysiology of all of
the endocrinopathies, and his work led to the description of the course of endocrine diseases. He
co‐authored approximately 100 papers and made more than 40 presentations at scientific
meetings around the world.

    The Kenny Award is given for outstanding research presentation by a fellow at the
MWSPR, and with sponsorship from Abbott Nutrition includes an honorarium and plaque.

                      1989           Michael S. (Mickey) Caplan, MD
                      1996           Brenda B. Poindexter, MD
                      2001           J. Carter Ralphe, MD
                      2002           Indra D. Chandrasekar, MD
                      2003           Heather Bartlett, MD
                      2004           Eyal Shteyer, MD
                      2005           Peter DeYoung, MD
                      2006           Rinku Mehra, MD
                      2007           Wendy Luce, MD
                      2008           Melissa Agoudemous, MD
                      2009           Suzanne Kingery, MD
                      2010           Misty Good, MD
                      2011           Andrew Harris, MD
                      2012           Brian Becknell, MD
                      2013           Brittany L. Knipstein, MD
                      2014           Jessica White, MD
                      2015           Kok‐Lim Kua, MD
                      2016           Rakhee Bowker, MD
                      2017           Stacy Kern, MD
                      2018           Awarded at the MWSPR Meeting

                                               15
The Jack Metcoff Award

        The Jack Metcoff Award is given for outstanding research presentation by a resident or
fellow at the MWSPR. The recipient receives a plaque and honorarium.

       Jack Metcoff made a major impact on the field of pediatric nephrology and body fluid
physiology. Throughout his career, Dr. Metcoff was the consummate teacher of clinical pediatrics
and pediatric nephrology, of a problem‐oriented approach to patient care, of the use of computers
in medicine, and of investigative attitudes and techniques.

        The Annual Conference on the Kidney, which he edited from 1950 to 1967, reflected the
best of basic and clinical research progress in those years and remains a hallmark of journalistic
excellence. As a leader and catalyst in the development of the Nephrosis Foundation, which
evolved into the National Kidney Foundation and the American Society of Nephrology, he helped
to lay the foundation for current professional and patient education.

                      1994            Bindya S. Singh
                      1995            Genie E. Roosevelt
                      1996            Raghavendra Rao
                      1997            Howard M. Katzenstein
                      1998            Rajeev Dixit
                      1999            Jennifer L. Kloesz
                      2000            Gregory Dalshaug
                      2001            Lisa K. Kelly
                      2002            Nancy B. Aspey
                      2003            Gerhard C. Hildebrandt
                      2004            Aaron K. Olson
                      2005            Christopher Linblade
                      2006            Todd D. Nebesio
                      2007            Nicholas Von Bergen
                      2008            Sundan Rajan
                      2009            Paul Mann
                      2010            Shaun Ashfield
                      2011            Dennis Slagel
                      2012            Brian Stansfield
                      2013            Lauritz Meyer
                      2014            Sophia Patel
                      2015            Jean Dinh
                      2016            Kyle Sabey
                      2017            Katie Satrom, MD
                      2018            Awarded at the MWSPR Meeting

                                                16
The William Segar Award

The William Segar Award was initiated in 2012 to be given annually to a student, resident or
fellow trainee with a hypothesis driven clinical research or behavioral/social or education project
that involves innovative improvement in patient care delivery.

Dr. Segar’s father was the first pediatrician to practice in the state of Indiana. Bill would earn both
his BS (1944) and MD (1947) from Indiana University. Dr. Segar has long been an advocate for
trainees and had served the MWSPR well as its 5th President and 2nd Founder’s Award winner. Dr.
William E. Segar was one of the 38 people who attended the first meeting of the Midwest Society
for Pediatric Research in Iowa City on October 27, 1959. He was present for the first business
meeting and voted on the bylaws of the Society. He became the 5th president of the MWSPR in
1965. He was an active member and organizer of the Salt & Water Club, an active group that met
adjacent to the MWSPR.

Together with Dr. Malcolm Holliday, he developed Holliday‐Segar equation for calculating fluid
therapy. Other than his time in the US Army at Walter Reed Medical Center, he trained and
practiced medicine exclusively in Pediatric Departments within the MWSPR territory, University
of Indiana, University of Illinois, Mayo Medical School, and finally the University of Wisconsin,
where he became Chair of Pediatrics. This award is sponsored by Friends of William E. Segar.

                       2012            Carl Backes, MD
                       2013            Shawna S. Shafer, MD
                       2014            Emma Austenfeld
                       2015            Brock Medsker, MD
                       2016            David Segar, MD
                       2017            John Fiester, MD
                       2018            Awarded at the MWSPR Meeting

                                                  17
Cleveland Clinic Award

The Cleveland Clinic awards Student Award is given for the most outstanding abstract
presentation by a trainee at a level prior to postgraduate training or residency. The Cleveland
Clinic has long supported the role of medical, graduate, undergraduate students, and even high
school students in the MWSPR and provides ongoing support for this award.

                      2001           Anthony Ratanproeksa
                      2002           Liza Cadnapaphornchai
                      2003           Karen Wiseman
                      2004           Emily Segar
                      2005           Amy Hurst
                      2006           Christopher Lux
                      2007           Keri Drake
                      2008           Christa Pittner
                      2009           Katie Meyer
                      2010           Emily Peterson
                      2011           Jeremy Sandgren
                      2012           Brandon Downing
                      2013           Richard C. Godby
                      2014           Micaela Zywicki
                      2015           Raymond Kreienkamp
                      2016           Matthew Murtha
                      2017           Haley Bremer
                      2018           Awarded at the MWSPR Meeting

                                               18
The Stanley Phillips Award

Awarded for the best poster or posters at the MWSPR meeting. This award is named after Stanley
Phillips III, a first year neonatology fellow at University of Wisconsin, who died during a transport
in 2013 from a terrible ambulance accident. Dr. Phillips was a kind and compassionate physician,
whom loved caring for ill newborns. He was looking forward to his research career and presenting
at the MWSPR meeting. However, his research and clinical career was cut short. In the short time
as a fellow, he was admired as an enthusiastic, inquisitive, thoughtful and caring physician. This
award is sponsored by Meriter Foundation and University of Wisconsin Department of Pediatrics,
Neonatology Division.

                       2013           Frances A. Boyle
                       2013           BreAnn Sheehan, MD
                       2014           Michael Thompson, MD
                       2015           Michael Thompson, MD
                       2016           Kristin Kan, MD, MPH
                       2017           June Hu, MD
                       2018           Awarded at the MWSPR Meeting

                                                 19
The Founder’s Award

The Founder’s Award is the highest honor given by the Midwest Society for Pediatric Research to
a senior member in recognition of contributions made in the development of the careers of
academic pediatricians and in the advancement of pediatric research. Since 1986, this award has
recognized some of the leaders in our field of pediatric research and academic medicine.

Mead Johnson Nutritionals has generously provided an honorarium and plaque to the recipients
during an awards luncheon held in honor of the recipient.

                      1986           Samuel J. Fomon, MD
                      1987           William E. Segar, MD
                      1988           Orville C. Green, MD
                      1989           Ira M. Rosenthal, MD
                      1990           Jean Holowach‐Thurston, MD
                      1991           William Weidman, MD
                      1992           Reginald D. Tsang, MD
                      1993           Rosita Pildes, MD
                      1994           Dharmapuir Vidyasagar, MD
                      1995           Fred G. Smith, MD
                      1996           Gunner B. Stickler, MD
                      1997           Dorothy J. Becker, M.B.B.Ch.
                      1998           Laurence A. Boxer, MD
                      1999           Robert T. Hall, MD
                      2000           Sherin U. Devaskar, MD
                      2001           Edward S. Ogata, MD
                      2002           Jean E. Robillard, MD
                      2003           Frank R. Greer, MD
                      2004           Robert P. Kelch, MD
                      2005           John A. Widness, MD
                      2006           James E. Heubi, MD
                      2007           Edward F. Bell, MD
                      2008           William E. Truog, MD
                      2009           Avory A. Fanaroff, MD
                      2010           Michael K. Georgieff, MD
                      2011           Juan F. Sotos, MD
                      2012           Alan H. Jobe, MD, PhD
                      2013           Howard Kilbride, MD
                      2014           Margaret K. Hostetter, MD
                      2015           Jeffrey Segar, MD
                      2016           Francis Sessions Cole, III, MD
                      2017           Valerie Opipari, MD
                      2018           Scott C. Denne, MD

                                               20
MIDWEST SOCIETY FOR PEDIATRIC RESEARCH, INC.

                                  Officers and Council Members
                                               2018

                                                President
                                  Laura S. Haneline, MD (2018-2019)
                                 University of Iowa Children’s Hospital

                                             Past President
                                    Jeffrey Segar, MD (2017-2018)
                                 University of Iowa Children’s Hospital

                                           President-Elect
                                   Neal Blatt, MD, PhD (2018-2019)
                                         Beaumont Children’s

                                             Secretary
                                    Carl Backes, MD (2018-2022)
                                    Nationwide Children's Hospital

                                             Treasurer
                                   Noah Hillman, MD (2016-2020)
                                 Cardinal Glennon Children's Hospital

                                 Council Members (three-year term)

Craig Garfield, MD (2019)                               Steve McElroy (2020)
Northwestern University                                 University of Iowa Hospital and Clinic

Lyndsay Harshman, MD (2020)                             Ulrike Mietzsch, MD (2020)
University of Iowa Hospital and Clinic                  Indiana University

Sarah Haskell, DO (2018)                                Steven Olsen, MD (2018)
University of Iowa Hospital and Clinic                  Children’s Mercy Kansas City

Ben Kopp, MD (2020)                                     Sara Ramel, MD (2019)
Nationwide Children's Hospital                          University of Minnesota

David McCulley, MD (2019)
University of Wisconsin

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