PROTON THERAPY MADE EASY - Proteus ONE

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PROTON THERAPY MADE EASY - Proteus ONE
Proteus ONE
COMPACT IMPT SOLUTION
                          ®

PROTON THERAPY
MADE EASY

                              Some features are
                              under development and
                              will be subject to review
                              by competent authorities
                              (FDA, Notified bodies,
                              et al...)

 www.iba-proteusone.com
PROTON THERAPY MADE EASY - Proteus ONE
PROTON THERAPY.
                               A TRUE SUCCESS IN CANCER CARE                                                                     Proteus ONE            ®

                                                                                                                             

                               Proton therapy is used today to treat many cancers and is particularly appropriate in             PROTON THERAPY MADE EASY
                               situations where treatment options are limited or conventional radiotherapy presents an
                                                                                                                                 ProteusONE is IBA’s compact single-
                               unacceptable risk to the patient.
                                                                                                                                 room proton therapy solution that can
                               These situations include eye and brain cancers, tumors close to the brain stem, spinal cord       be integrated easily into many kinds
                               or other vital organs, prostate cancers, recurring cancers and pediatric cancers.                 of healthcare settings. Much smaller
                                                                                                                                 and more affordable than conventional
                                                                                                                                 multi-room proton systems, but with the
                                                        Proton therapy vs X-ray radiation                                        same clinical applications, ProteusONE
                                                                                                                                 makes proton therapy more accessible
                                                                                                                                 to clinical institutions worldwide and to
                                                                                                                                 their cancer patients.
                                                                                                                                 Benefiting from IBA’s unrivalled
                                                                                                                                 experience in proton therapy,
                                                                                                                                 ProteusONE delivers the latest
                                                                                                                                 advance in proton radiation therapy,
                                                                                                                                 Intensity Modulated Proton Therapy
                                                                                                                                 (IMPT). IMPT combines the precise
                                                                                                                                 dose delivery of Pencil Beam Scanning
                                                                                                       HEAD AND NECK             (PBS) with the dimensionally accurate
                                                                                                                                 imaging of 3D Cone Beam Computed
                                                                                                                                 Tomography (CBCT), enabling
                                                                                                                                 physicians to truly track where protons
                                                                                                                                 will be targeting tumor cells.
                                          	
                                        	
                                           ProteusONE was inspired by everyday
                                                                                                                                 clinical practice. Its patient-centered
                                                                                                                                 design was developed in collaboration
                                                                                                                                 with Philips Healthcare to foster a
                                                                                                                                 soothing patient environment while
                                                                                                                                 helping the medical staff work more
                                                                                                  PROSTATE CARCINOMA             efficiently.
                                                                                                                                 The powerful combination of smaller
                                                                                                                                 system size, clinical capabilities
                                                                                                                                 and patient-centered design is why
                                                                                                                                 ProteusONE is being adopted by
For a general overview
of the clinical aspects of                 	
                                       	
                                           more community-based and advanced
proton therapy, refer to the                                                                                                     institutions around the world.
following works:
- “Proton and charged
   particle radiotherapy”
   by Thomas F. Delaney,
   Hanne M. Kooy
- “Proton Therapy”,
   Series: Radiation
   Medicine Rounds                           Images with the courtesy of Stefan Both, Ph D.       PEDIATRIC CHORDOMA
   Volume 1 Issue 3 by
   James M. Metz and
   Charles R. Thomas, Jr.

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PROTON THERAPY MADE EASY - Proteus ONE
TREATING WITH
                           Proteus ONE                      ®

                           IBA’s ProteusONE is a compact single
                           room proton therapy solution offering all
                           the clinical capabilities of a conventional
                           multi-room proton system, including
                           IMPT, the latest advance in proton
                           treatment methods.
                           IMPT lets radiation oncologists adjust the
                           precision, depth and intensity of a proton
                           beam to the peaks and valleys of complex
                           tumors while sparing nearby healthy
                           tissue. Tumors like these are typically
                           found in the neck, head and spine. The
                           precision and adaptability of IMPT makes
                           it particularly well suited for treating
                           tumors that are adjacent to vital organs.
                           ProteusONE enables IMPT by combining
                           the fine precision of the Pencil Beam
                           Scanning delivery mode with the accuracy

                                                                                                      Y
                                                                                                    AP
                           of 3D Cone-Beam Computed Tomography
                                                                                       ER

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PROTON THERAPY MADE EASY - Proteus ONE
TREATING WITH INTENSITY
                       MODULATED PROTON THERAPY

                       ProteusONE delivers the proton beam to           WHAT IS PENCIL BEAM SCANNING ?
                                                                                                                                                                       DELIVER ACCURATE PROTON TREATMENTS
                       the tumor using the Pencil Beam Scanning         PBS is a proton beam delivery mode.                                     Trea t ment
                                                                                                                                                Sui te                 WITH EASE
                       (PBS) modality.                                  The proton beam paints the target volume,
                                                                                                                                                                       IBA presents its integrated proton therapy
                       Thanks to its advanced technical and             one layer at a time, pixel by pixel, to
                                                                                                                                                                       software suite, adapt Treatment Suite.
                       clinical capabilities, PBS enables a             precisely match the shape of the tumor.
                                                                                                                       This modular software platform is proposing a truly integrated treatment environment
                       clinician’s delivery of Intensity Modulated      IMPT treats a small section of the tumor
                                                                                                                       for safe and efficient proton therapy delivery.
                       Proton Therapy to cancer patients.               at a time, adjusting the proton beam dose
                       IMPT precisely targets the tumor while           and depth to wider and narrower contours
                                                                                                                                                 is the front-end of the treatment delivery. It incorporates
                       controlling the intensity and spatial            of the tumor, section by section. Combined
                                                                                                                       the different delivery techniques, such as Pencil Beam Scanning, and it offers
                       distribution of the dose with fine precision.    with the appropriate imaging devices and
                                                                                                                       ergonomic screens for streamlined control of the patient treatment, along with full
                       With ProteusONE IMPT capabilities, you           treatment strategies, IMPT is capable of
                                                                                                                       integration of the TPS and OIS through DICOM connectivity.
                       will have the ability to precisely model the     treating moving tumors.
                       dose on the target tumor, reaching high          The key advantages of PBS:
                                                                                                                                                   allows editing of treatment plans and prescriptions for
                       levels of conformality and dose uniformity,      — It sculpts the dose with very high levels
                                                                                                                       standalone or QA modes.
                       especially for complex tumors, with fewer            of conformality and dose uniformity,
                       treatment beams.                                     even in complex-shaped tumors, thanks
                                                                            to its fine precision.
                                                                        — It enables Intensity Modulated Proton
                                                                            Therapy (IMPT).
                                                                        —	It makes treatment planning
                                                                            easier, while eliminating the need
                                                                            for individualized aperture and
                                                                            compensator devices.
                                                                        — It delivers the smallest possible neutron
                                                                            dose to the patient during treatment.

                         “At the Willis-Knighton Cancer Center in Shreveport, LA, we wanted to offer the latest
                         form of proton therapy, pencil beam scanning, while taking advantage of advances in
                         image guidance and remaining within the budget of our hospital system.
                         We needed assurances that our partner had experience in designing, installing, and
                         maintaining a proton therapy facility but had also had the financial strength to invest in
                         research and development for the future.
                         IBA has continually demonstrated innovation in the field of proton therapy and they
                         were chosen for their unique ability to meet our department needs.”
                         Lane R Rosen MD
                         Director of Radiation Oncology, Willis Knighton Cancer Center

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PROTON THERAPY MADE EASY - Proteus ONE
DELIVERING THE BEAM TO
                       THE NEAREST MILLIMETER

                       ProteusONE brings together the most          Its smooth, deliberate motion positions
                       advanced techniques of patient positioning   the patient so that the target is precisely
                       for proton therapy treatments. It enables    placed for receiving the treatment beam.
                       your treatment procedures to optimize        Adjustments to the patient’s position are
                       proton beam precision — in dose, depth       automatically transferred from the IGPT
                       and contour. Developed over the years by     system to the positioning controller.
                       IBA and our clinical partners, our proton    IBA’s Robotic Patient Positioning System
                       beam technology has proven successful        (RPPS) offers:
                       in delivering the proton beam with           — Treatment flexibility: Patient positioner
                       fine precision.                                  with 6 degrees of freedom (horizontal,
                       ROBOTIC PATIENT                                  lateral, vertical, rotation, pitch and roll
                       POSITIONING SYSTEM                               movements are possible).
                       Properly positioning the patient with the    — Treatment precision: High positioning
                       utmost care while to ensure the precise          accuracy and reproducibility.
                       delivery of proton fractions is a key to     —P   atient comfort: Increased smoothness
                       clinical effectiveness.                          and reliability.
                       The Robotic Patient Positioning System
                       incorporated into ProteusONE is a safe,
                       robust and accurate device equipped
                       with interchangeable treatment tabletops.

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PROTON THERAPY MADE EASY - Proteus ONE
TOWARDS ADAPTIVE IMAGE-GUIDED
                         PROTON THERAPY

                         IBA’s ProteusONE incorporates the latest     2.5D ORTHOGONAL X-RAY                          3D CONE-BEAM CT IMAGE-GUIDED                  treatment through anatomical modification
                         imaging technologies so clinicians can       AND FLUOROSCOPY*                               PROTON THERAPY (IGPT)                         assessment, the first step towards adaptive
                         deliver Image-Guided Proton Therapy          Oblique stereoscopic X-Ray imaging and         3D volumetric X-Ray imaging, Cone-Beam        radiation therapy.
                         (IGPT) to cancer patients. IGPT relies on    fluoroscopy allow accurate patient position    Computed Tomography (CBCT), can be            With the advanced imaging technologies
                         high-resolution and high-sensitivity X-Ray   verification and monitoring.                   directly acquired in the treatment room       built into ProteusONE, clinical users can
                         digital imaging systems that provide         Fluoroscopy is an imaging technique that       at isocenter. It can then be compared         now apply similar advanced positioning
                         low-dose stereoscopic and 3D imaging in      produces a real-time x-ray video of internal   with treatment planning CT for patient        and Quality Assurance protocols as those
                         various geometrical arrangements.            body structures. The system enables the        position verification and anatomical          used in their Image-Guided Radiation
                         The advanced imaging technologies            medical staff to observe the position of the   modification assessment.                      Therapy (IGRT) practice.
                         integrated in ProteusONE ensure quick        tumor relative to the treatment target area    Advanced acquisition software, shading        IBA’s ProteusONE brings the
                         and accurate patient position verification   during treatment. For clinical indications     correction, accelerated inline and offline    advantages of:
                         by comparison with diagnostic CT imaged      that are sensitive to movements of the         image reconstruction algorithms support       — Acquiring CBCT image in room and
                         during the treatment planning process.       patient’s organs, fluoroscopy enables direct   high-speed, high-resolution, uniform and         at isocenter.
                                                                      intra-fraction motion monitoring.              low-dose CBCT.                                — Ensuring accurate patient positioning
                                                                                                                     CBCT offers excellent soft-tissue contrast,      during treatment.
                                                                                                                     providing much more information than          — Enabling the detection of anatomic
                                                   is the IBA imaging platform. It is part of IBA’s integrated       a conventional stereoscopic alignment            modifications within the patient along
                          proton therapy software suite, adapt Treatment Suite. It incorporates image-guidance       system, and allowing more accurate patient       the radiological path.
                          features such as 3D CBCT and stereoscopic X-Ray imaging for highly accurate patient
                          treatment, as well as tight integration with adapt deliver. An open architecture and
                          programmable workflow configurability builds a solid foundation for the development of
                          future proton specific image-guided solutions.

      * Fluoroscopy is
           CE marked.

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PROTON THERAPY MADE EASY - Proteus ONE
A DESIGN
                            INSPIRED BY
                            CLINICAL CARE
                            Working with clinicians and nurses in the
                            development of proton therapy worldwide
                            over the last 25 years has led IBA to
                            understand that successful treatment
                            does not just depend upon the successful
                            application of proton beam physics. The
                            everyday treatment experience is also
                            important — for the patient and clinician.
                            ProteusONE is designed to enhance the
                            patient experience by fostering a soothing
                            environment. At the same time, all care
                            has been taken to facilitate medical staff
                            daily practice.
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PROTON THERAPY MADE EASY - Proteus ONE
TURNING HEALTHCARE
                        OPTIMIZED STAFF EXPERIENCE                                                                  INTO HUMAN CARE

                                                                                                                                                                  BENEFITS OF AMBIENT EXPERIENCE
                                                                                                                                                                  —F
                                                                                                                                                                    or the patients and families:
                                                                                                                                                                    • Reduced anxiety and
                                                                                                                                                                       increased comfort.
                                                                                                                                                                    • Higher patient satisfaction.
                                                                                                                                                                  —F
                                                                                                                                                                    or the staff:
                                                                                                                                                                   • Increased working comfort.
                                                                                                                                                                   • Better patient interaction.
                                                                                                                                                                   • Higher job effectiveness with improved
                                                                                                                                                                      staff experience and satisfaction.
                                                                                                                                                                  —F
                                                                                                                                                                    or the hospital management:
                                                                                                                    While focusing on clinical efficiency          • Improved workflow and throughput.
                                                                                                                    and interoperability, ProteusONE also          • Improved patient satisfaction leading to
                                                                                                                    incorporates environmental features to            word-of-mouth endorsement.
                                                                                                                    help keep patients relaxed and comfortable     • Attracting and retaining highly
                                                                                                                    during imaging and treatment.                     trained clinical staff and reducing
                                                                                                                    Based on insights from proton patients,           overhead costs.
                                                                                                                    healthcare staff and experts, Philips
                                                                                                                    Healthcare and IBA integrated a solution
                                                                                                                    that improves the overall patient and staff
                                                                                                                    experience; turning a cold, impersonal
                                                                                                                    environment into one that comforts and
                                                                                                                    reassures.

                                                                                                                    Philips received the “International Red
                        OPEN TREATMENT ENCLOSURE                      staff as the gantry rotates around the        Dot Award : Product design 2014” for the
                                                                      isocenter (220°). The GRF ensures staff       Ambient Experience associated to the
                        ProteusONE is designed with an open
                                                                      safety during clinical operations, allowing   ProteusONE.
                        treatment enclosure. It allows the
                                                                      them to focus on their core tasks and tend
                        physicians and nurses to have easy                                                          Acknowledged as the best quality
                                                                      to patient wellbeing.
                        access to the patient during positioning,                                                   and groundbreaking design, Ambient
                        imaging and treatment. This facilitates       IN-ROOM IMAGING CONTROL                       Experience helps enhance the overall
                        patient care and comfort, and improves                                                      experience for oncology patients and staff.     AMBIENT EXPERIENCE IN FIGURES*
                                                                      ProteusONE permits radiation therapists
                        positioning procedures especially during                                                                                                    — 76% increase in staff satisfaction
                                                                      and clinicians to access and control
                        non-coplanar treatments.                                                                                                                    —4 % overall decrease in
                                                                      patient imaging from inside the treatment
                                                                                                                                                                      procedure duration
                        GANTRY ROLLING FLOOR (GRF)                    room. This permits improved patient care,
                                                                                                                                                                    — 6% overall patient increase
                                                                      greater ease of use and efficient patient
                        Thanks to the highly functional design of                                                                                                   * Philips installed base survey “What do our   In partnership with
                                                                      positioning.
                        our Gantry Rolling Floor (GRF), the patient                                                                                                    customers say”, 100 customers interviewed,
                                                                                                                                                                       27 countries (excl.NA) in September 2011.
                        remains very accessible to the treatment

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PROTON THERAPY MADE EASY - Proteus ONE
PROTON
                        THERAPY
                        MADE COMPACT                                   WHEN SIZE MATTERS

                        Through the development of proton              In many areas, size matters. This is                                                                        COMPACT
                                                                                                                                                                         SYNCHRO-CYCLOTRON
                        therapy projects worldwide with many           particularly true in a high-tech medical
                        different clinical institutions, IBA has       facility where every square foot
                        learned that the biggest challenge is          is invaluable. There is a common
                        neither advancing this leading-edge            misconception that proton therapy requires
                        technology, nor convincing clinicians                                                                                                          220° COMPACT GANTRY
                                                                       a large — and costly — facility in which                                                            TREATMENT ROOM
                        of its clinical effectiveness. The biggest     to operate. As a consequence, too many
                        challenge is making this vital technology      facility executives look at the space and
                        accessible to more cancer patients around      capital they have available and quickly
                        the world.                                     deem a proton center to be impossible.
                        This is the challenge that IBA has taken on.
                                                                       The IBA team has worked relentlessly to
                        ProteusONE is our response — a proton          prove this belief to be false.                  220° OF TREATMENT FREEDOM
                        therapy system that is smaller, more                                                           FOR IMPROVED PATIENT AND
                        affordable, easier to install, easier to       The result is ProteusONE: a proton therapy
                                                                       solution with a footprint limited to the size   STAFF EXPERIENCE
                        operate and ultimately easier to finance.
                                                                       of two typical linac vaults.                    IBA offers the first compact gantry on
                        With ProteusONE, the power of protons is
                                                                                                                       the market that extends the treatment
                        possible for more patients worldwide.
                                                                        COMPACT ACCELERATION WITH MINIMAL              angle to 220°. In doing so, your clinicians
                                                                        NEUTRON DOSE                                   benefit from 220° of treatment freedom
                                                                        Acceleration of the proton beam in             and uncompromised treatment options.
                                                                        ProteusONE is performed by IBA’s               The open treatment enclosure allows
                                                                        specially designed Superconducting             physicians and nurses to have easy
                                                                        Synchro-Cyclotron*. This technology            access to the patient in treatment position.
                                                                        reduces the accelerator weight and             This facilitates patient care and comfort,
                                                                        energy consumption by a factor of four.        and improves positioning procedures
                                                                                                                       especially during non-coplanar treatments.
                                                                        In order to ensure the safest treatment
                                                                        at all time, the scanning controller           The IBA 220° Compact Gantry provides the
                                                                        performs 1 million measurements per            perfect equilibrium associating the strength,
                                                                        second, allowing to take 60,000 safety         reliability and speed in a compact and
                                                                        decisions per second.                          patient-friendly treatment solution.

                                                                        Our compact accelerator is mounted             The IBA Open Compact Gantry Treatment
                                                                        outside of the treatment room which            Room combines a compact gantry design
                                                                                                                                                                       * IBA’s Superconducting
                                                                        dramatically reduces neutron exposure.         with the following advantages:                     Synchro-Cyclotron,
                                                                                                                                                                          S2C2, is under
                                                                                                                       —O  ptimized access and comfort for               development. The
                                                                        On average, it releases 7 times less
                                                                                                                          patients and staff.                             marketing approval will
                                                                        neutron dose to the surrounding                                                                   be subject to review by
                                                                                                                       — Accurate patient positioning systems.           competent authorities
                                                                        healthy tissues compared to a                                                                     (FDA, Notified bodies,
                                                                                                                       —R  educed cost and shorter                       et al…).
                                                                        Scattering Gantry Mounted accelerator**.
                                                                                                                          installation time.
                                                                                                                                                                       ** Based on Monte Carlo
                                                                                                                                                                           Simulations.

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PROTON THERAPY MADE EASY - Proteus ONE
LEADING INSTITUTIONS HAVE
                        ALREADY CHOSEN IBA. JOIN THEM
                        TO DEVELOP THE FUTURE OF
                        CANCER CARE TOGETHER

                        STAY FOCUSED ON PATIENT CARE,
                                                                        OPERATION AND MAINTENANCE SERVICES
                        WE CAN RUN THE SYSTEM FOR YOU                   IN A NUTSHELL
                        Our experience installing proton systems at     With the largest team of proton experts
                        more than half of the clinical proton therapy   around the world, you can have access
                        centers worldwide has led us to understand      to our qualified field support team at
                        the worries and clinical complexities           any time, day and night. In addition
                        that arise when treating cancer.                to personalized support, other key
                        Our commitment is to ensure your clinical       services are provided:
                        success by providing reliable systems           — 24/7 remote support service,
                        with the highest availability possible —           online or over the phone, is an
                        over 95% uptime. The dependability and             important component to keep your
                        reliability of IBA proton systems means you        equipment’s high uptime.
                        can schedule patient treatments — and           — A team of IBA trained specialists
                        necessary clinical staff — with confidence.        will operate the system onsite
                        To date, being part of the IBA proton              to ensure the highest level of
                        therapy client network and benefiting              availability for clinical treatment.
                        from our technical expertise has helped         — In case of emergency, we can
                        centers around the world to treat over             deliver spare parts the same
                        25,000 cancer patients worldwide.                  day via our extensive spare parts
                                                                           worldwide network with hubs in
                        Your team can focus on the clinical aspects
                                                                           America, Asia and Europe.
                        of cancer care while IBA’s team keeps
                                                                        — Because technology changes
                        your proton therapy system running at top
                                                                           quickly, IBA develops both update
                        performance and meets the highest safety
                                                                           and upgrade packages tailored
                        and reliability standards.
                                                                           to your center’s configuration and
                                                                           training programs to increase your
                                                                                                                  Lane R Rosen MD, Director of
                                                                           team’s efficiency.
                                                                                                                  Radiation Oncology, Willis Knighton
                                                                        NEW SERVICE FEATURES INCLUDE:             Cancer Center, tells us about
                                                                        — Remote Service Connections to          ProteusONE installation processes :
                                                                           proton therapy accelerator systems;
                                                                                                                  “IBA has placed staff locally to
                                                                        — Worldwide Computerized
                                                                                                                  assure the process remains fluid.
                                                                           Maintenance Management
                                                                                                                  They have demonstrated that they can
                                                                           Systems.
                                                                                                                  efficiently deliver this support within
                                                                                                                  our hospital budget.
                                                                                                                  We are confident that IBA will assist
                                                                                                                  with the operation and maintenance
                                                                                                                  of our facility in the same manner in
                                                                                                                  which they have behaved thus far.”

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IBA HAS DESIGNED AND INSTALLED
                         THE MAJORITY OF CLINICALLY
                         OPERATING PROTON THERAPY
                         CENTERS IN THE WORLD.

                         NORTH AMERICA NETWORK                                                                                                        EUROPE NETWORK                                              ASIA NETWORK
                         4                             3                                3                                  4                          4                               4                            3
                        ROOMS                         ROOMS                            ROOMS                             ROOMS                       ROOMS                           ROOMS                       ROOMS

                         CDH PROTON THERAPY            THE PROTON THERAPY CENTER LLC    MASSACHUSETTS GENERAL HOSPITAL    UNIVERSITY OF FLORIDA       WESTDEUTSCHES                   PROTON THERAPY CENTER       NATIONAL CANCER CENTER
                         CENTER, A PROCURE CENTER      (TPTC) PROVISION HEALTHCARE      BURR PROTON THERAPY CENTER        PROTON THERAPY INSTITUTE    PROTONENTHERAPIEZENTRUM         CZECH S.R.O.                Ilsan, Korea
                         Warrenville, IL, USA          Knoxville, TN, USA               Boston, MA, USA                   Jacksonville, FL, USA       ESSEN (WPE)                     Prague, Czech Republic      Treating since 2007
                         Treating since 2010           Treating since 2014              Treating since 2001               Treating since 2006         Essen, Germany                  Treating since 2012
                                                                                                                                                                                                                  3
                         5                             4                                                                  3                           Treating since 2013                                        ROOMS
                        ROOMS
                                                                                        4
                                                      ROOMS                            ROOMS                             ROOMS
                                                                                                                                                      2                               2
                                                                                                                                                     ROOMS                           ROOMS

                                                                                                                                                                                                                  APOLLO
                         UNIVERSITY OF PENNSYLVANIA    PROCURE PROTON THERAPY           SCCA PROTON THERAPY               TEXAS CENTER                                                                            PROTON THERAPY CENTER
                         HEALTH SYSTEM ROBERTS         CENTER IN OKLAHOMA CITY          A PROCURE CENTER                  FOR PROTON THERAPY          AZIENDA PROVINCIALE PER I       CENTRE DE PROTONTHÉRAPIE    Chennai, India
                         PROTON THERAPY CENTER         Oklahoma City, OK, USA           Seattle, WA, USA                  Dallas, TX, USA             SERVIZI SANITARI (APSS)         DE I’INSTITUT CURIE         Opening in 2016
                         Philadelphia, PA, USA         Treating since 2009              Treating since 2013               Opening in 2015             Trento, Italy                   Paris (Orsay), France
                         Treating since 2009
                                                                                                                                                                                                                   2
                                                                                                                                                      Opening in 2014                 Treating since 2009        ROOMS
                                                       1                                4
                          5                           ROOM                             ROOMS                                                          1                               2
                        ROOMS                                                                                                                        ROOM                            ROOMS

                                                                                                                                                                                                                  WANJIE
                                                       WILLIS-KNIGHTON                  PROCURE PROTON                                                                                                            PROTON THERAPY CENTER
                         HAMPTON UNIVERSITY                                                                                                           CENTRE ANTOINE                  SKANDIONKLINIKEN            Zibo, China
                                                       CANCER CENTER                    THERAPY CENTER
                         PROTON THERAPY INSTITUTE                                                                                                     LACASSAGNE                      Uppsala, Sweden             Treating since 2004
                                                       Shreveport, LA, USA              Somerset, NJ, USA
                         Hampton, VA, USA              Opening in 2014                  Treating since 2012                                           Nice, France                    Opening in 2015
                         Treating since 2010                                                                                                          Opening in 2015
                                                                                                                                                                                                                  1
                                                                                                                                                                                                                 ROOM
                                                                                                                                                      2                               1
                                                                                                                                                     ROOMS                           ROOM

                                                                                                                                                                                                                  CHC TAIPEI
                                                                                                                                                                                                                  PROTON THERAPY CENTER
                                                                                                                                                      BRONOWICE CYCLOTRON             UNIVERSITATKLINIKUM
                                                                                                                                                                                                                  Taipei, Taiwan
                                                                                                                                                      CENTER                          CARL GUSTAV CARUS           Opening in 2016
                                                                                                                                                      Kraków, Poland                  Dresden, Germany
                                                                                                                                                      Treating since 2013             Opening in 2014              1
                                                                                                                                                                                                                 ROOM
                                                                                                                                                      4
                                                                                                                                                     ROOMS

                                                                                                                                                                                                                  NATIONAL
                                                                                                                                                      FEDERAL HIGH-TECH                                           PROTON THERAPY CENTER
                                                                                                                                                      MEDICAL CENTER                                              Japan
                                                                                                                                                                                                                  Opening in 2017
                                                                                                                                                      Dimitrovgrad, Russia, Europe
                                                                                                                                                      Opening in 2015                                              1
                                                                                                                                                                                                                 ROOM

                                                                                                                                                                                                                  COMPACT
                                                                                                                                                                                                                  PROTON THERAPY CENTER
                                                                                               Proteus®PLUS                                                                                                       Japan
                                                                                                                                                                                                                  Opening in 2017
                                                                                            Proteus®ONE

                                                                                       This map has been last updated in August 2014.

IBA Proteus ONE // 18
           ®
                                                                                                                                                                                                                                    19 // IBA Proteus ONE
                                                                                                                                                                                                                                                   ®
CONTACT US

                        AMERICAS                         While all care has been taken to ensure
                        Toll-free: 1 877 IBA 4 PBT       that the information contained in this
                        T +1 904 491 6080                publication is correct, we accept no
                                                         responsibility for any inaccuracy and
                        EUROPE, MIDDLE EAST AND AFRICA   reserve the right to modify this information.
                        T +32 10 203 342                 Technical specifications are based on
                        F +32 10 475 923                 standard operating conditions and may be
                                                         subject to variations.
                        RUSSIA & CIS                     Pictures and illustrations are
                        T/F +7 495 648 69 00             not contractual.
                        E-mail: info@iba-russia.ru
                                                         ProteusONE is the brand name of a new
                        ASIA PACIFIC                     configuration of the Proteus 235 including
                        T +86 10 8080 9186               some new developments subject to review
                                                         by competent authorities before marketing.
                                                         Empath is a registered trademark of IBA
                                                         Particle Therapy.

                        E-mail: info-pt@iba-group.com    AdaPT insight is the brand name of
                        Visit us online at:              the I2C software suite applicable to the
                        www.iba-proteusone.com           IBA Proton Therapy solutions.

                                                         IBA, a Belgian company, is listed on
                                                         the pan-European stock exchange
                                                         EURONEXT and its annual reports can be
                                                         downloaded on the website:
                                                         www.iba-worldwide.com

                                                         Published by IBA S.A.,
                                                         Chemin du Cyclotron, 3
                                                         1348 Louvain-la-Neuve, Belgium.

                                                         This brochure is printed on ECF woodfree
                                                         uncoated paper. It was produced with
                                                         plants that comply with ISO 14001,
                                                         the environmental management standard.

IBA Proteus ONE // 20
           ®
IBA Group | 2014 | IBAL01/4024 | ProteusONE | August 2014

                                                            IBA, THE HIGH WAY TO PROTON THERAPY
                                                            In proton therapy, the development of practical and patient-centered
                                                            solutions is only possible through constant collaboration, open engagement
                                                            and shared research objectives. With more than 25 years of experience
                                                            designing and developing proton therapy systems across the globe, IBA
                                                            has grown a strong and vital community of proton therapy professionals.
                                                            Together, this unprecedented community - of clinical leaders and
                                                            distinguished technological experts - is advancing proton beam technology
                                                            and clinical innovations.

                                                            By entering the IBA Proteus community:

                                                                  — Your clinicians and researchers will leverage the latest outcome-
                                                                     driven practices being advanced on a common technological
                                                                     platform. Sharing with a community of experienced clinical proton
                                                                     beam users will give them the capacity of your team to be trained
                                                                     with the utmost care and the highest standards of quality.

                                                                  — Your
                                                                        project management team will be able to collaborate with
                                                                    the world’s most experienced team of proton therapy experts
                                                                    (600+), cutting-edge technology and robust processes in system
                                                                    installation and operation.

                                                                  — Your
                                                                       executive team will leverage the know-how and clinical
                                                                    understanding built on 25+ projects and 25,000+ patients treated to
                                                                    secure the institutions’ investment.

                                                            Together with our people, by sharing our passion for innovation and patient
                                                            care, you can take comfortably the highway to the future of cancer care.
                                                            The IBA Proteus Community includes among others Massachusetts General Hospital
                                                            Burr Proton Therapy Center, ProCure Proton Therapy Centers, University of Florida
                                                            Proton Therapy Institute, University of Pennsylvania Health System Roberts Proton
                                                            Therapy Center… in North America; or Centre de Protonthérapie Orsay de I’Institut Curie,
                                                            Universitätsklinikum Carl Gustav Carus …in Europe; and Korean National Cancer Center,
                                                            Appolo Health Group… in Asia.

                                                            VISIT US ONLINE AT:
                                                            www.iba-protontherapy.com

                                                             www.iba-proteusone.com
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