PROTON THERAPY MADE EASY - Proteus ONE
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Proteus ONE
COMPACT IMPT SOLUTION
®
PROTON THERAPY
MADE EASY
Some features are
under development and
will be subject to review
by competent authorities
(FDA, Notified bodies,
et al...)
www.iba-proteusone.com
PROTON THERAPY.
A TRUE SUCCESS IN CANCER CARE Proteus ONE ®
Proton therapy is used today to treat many cancers and is particularly appropriate in PROTON THERAPY MADE EASY
situations where treatment options are limited or conventional radiotherapy presents an
ProteusONE is IBA’s compact single-
unacceptable risk to the patient.
room proton therapy solution that can
These situations include eye and brain cancers, tumors close to the brain stem, spinal cord be integrated easily into many kinds
or other vital organs, prostate cancers, recurring cancers and pediatric cancers. of healthcare settings. Much smaller
and more affordable than conventional
multi-room proton systems, but with the
Proton therapy vs X-ray radiation same clinical applications, ProteusONE
makes proton therapy more accessible
to clinical institutions worldwide and to
their cancer patients.
Benefiting from IBA’s unrivalled
experience in proton therapy,
ProteusONE delivers the latest
advance in proton radiation therapy,
Intensity Modulated Proton Therapy
(IMPT). IMPT combines the precise
dose delivery of Pencil Beam Scanning
HEAD AND NECK (PBS) with the dimensionally accurate
imaging of 3D Cone Beam Computed
Tomography (CBCT), enabling
physicians to truly track where protons
will be targeting tumor cells.
ProteusONE was inspired by everyday
clinical practice. Its patient-centered
design was developed in collaboration
with Philips Healthcare to foster a
soothing patient environment while
helping the medical staff work more
PROSTATE CARCINOMA efficiently.
The powerful combination of smaller
system size, clinical capabilities
and patient-centered design is why
ProteusONE is being adopted by
For a general overview
of the clinical aspects of
more community-based and advanced
proton therapy, refer to the institutions around the world.
following works:
- “Proton and charged
particle radiotherapy”
by Thomas F. Delaney,
Hanne M. Kooy
- “Proton Therapy”,
Series: Radiation
Medicine Rounds Images with the courtesy of Stefan Both, Ph D. PEDIATRIC CHORDOMA
Volume 1 Issue 3 by
James M. Metz and
Charles R. Thomas, Jr.
1 // IBA Proteus ONE
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TREATING WITH
Proteus ONE ®
IBA’s ProteusONE is a compact single
room proton therapy solution offering all
the clinical capabilities of a conventional
multi-room proton system, including
IMPT, the latest advance in proton
treatment methods.
IMPT lets radiation oncologists adjust the
precision, depth and intensity of a proton
beam to the peaks and valleys of complex
tumors while sparing nearby healthy
tissue. Tumors like these are typically
found in the neck, head and spine. The
precision and adaptability of IMPT makes
it particularly well suited for treating
tumors that are adjacent to vital organs.
ProteusONE enables IMPT by combining
the fine precision of the Pencil Beam
Scanning delivery mode with the accuracy
Y
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of 3D Cone-Beam Computed Tomography
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(CBCT) imaging. TH
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TREATING WITH INTENSITY
MODULATED PROTON THERAPY
ProteusONE delivers the proton beam to WHAT IS PENCIL BEAM SCANNING ?
DELIVER ACCURATE PROTON TREATMENTS
the tumor using the Pencil Beam Scanning PBS is a proton beam delivery mode. Trea t ment
Sui te WITH EASE
(PBS) modality. The proton beam paints the target volume,
IBA presents its integrated proton therapy
Thanks to its advanced technical and one layer at a time, pixel by pixel, to
software suite, adapt Treatment Suite.
clinical capabilities, PBS enables a precisely match the shape of the tumor.
This modular software platform is proposing a truly integrated treatment environment
clinician’s delivery of Intensity Modulated IMPT treats a small section of the tumor
for safe and efficient proton therapy delivery.
Proton Therapy to cancer patients. at a time, adjusting the proton beam dose
IMPT precisely targets the tumor while and depth to wider and narrower contours
is the front-end of the treatment delivery. It incorporates
controlling the intensity and spatial of the tumor, section by section. Combined
the different delivery techniques, such as Pencil Beam Scanning, and it offers
distribution of the dose with fine precision. with the appropriate imaging devices and
ergonomic screens for streamlined control of the patient treatment, along with full
With ProteusONE IMPT capabilities, you treatment strategies, IMPT is capable of
integration of the TPS and OIS through DICOM connectivity.
will have the ability to precisely model the treating moving tumors.
dose on the target tumor, reaching high The key advantages of PBS:
allows editing of treatment plans and prescriptions for
levels of conformality and dose uniformity, — It sculpts the dose with very high levels
standalone or QA modes.
especially for complex tumors, with fewer of conformality and dose uniformity,
treatment beams. even in complex-shaped tumors, thanks
to its fine precision.
— It enables Intensity Modulated Proton
Therapy (IMPT).
— It makes treatment planning
easier, while eliminating the need
for individualized aperture and
compensator devices.
— It delivers the smallest possible neutron
dose to the patient during treatment.
“At the Willis-Knighton Cancer Center in Shreveport, LA, we wanted to offer the latest
form of proton therapy, pencil beam scanning, while taking advantage of advances in
image guidance and remaining within the budget of our hospital system.
We needed assurances that our partner had experience in designing, installing, and
maintaining a proton therapy facility but had also had the financial strength to invest in
research and development for the future.
IBA has continually demonstrated innovation in the field of proton therapy and they
were chosen for their unique ability to meet our department needs.”
Lane R Rosen MD
Director of Radiation Oncology, Willis Knighton Cancer Center
IBA Proteus ONE // 4
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DELIVERING THE BEAM TO
THE NEAREST MILLIMETER
ProteusONE brings together the most Its smooth, deliberate motion positions
advanced techniques of patient positioning the patient so that the target is precisely
for proton therapy treatments. It enables placed for receiving the treatment beam.
your treatment procedures to optimize Adjustments to the patient’s position are
proton beam precision — in dose, depth automatically transferred from the IGPT
and contour. Developed over the years by system to the positioning controller.
IBA and our clinical partners, our proton IBA’s Robotic Patient Positioning System
beam technology has proven successful (RPPS) offers:
in delivering the proton beam with — Treatment flexibility: Patient positioner
fine precision. with 6 degrees of freedom (horizontal,
ROBOTIC PATIENT lateral, vertical, rotation, pitch and roll
POSITIONING SYSTEM movements are possible).
Properly positioning the patient with the — Treatment precision: High positioning
utmost care while to ensure the precise accuracy and reproducibility.
delivery of proton fractions is a key to —P atient comfort: Increased smoothness
clinical effectiveness. and reliability.
The Robotic Patient Positioning System
incorporated into ProteusONE is a safe,
robust and accurate device equipped
with interchangeable treatment tabletops.
IBA Proteus ONE // 6
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TOWARDS ADAPTIVE IMAGE-GUIDED
PROTON THERAPY
IBA’s ProteusONE incorporates the latest 2.5D ORTHOGONAL X-RAY 3D CONE-BEAM CT IMAGE-GUIDED treatment through anatomical modification
imaging technologies so clinicians can AND FLUOROSCOPY* PROTON THERAPY (IGPT) assessment, the first step towards adaptive
deliver Image-Guided Proton Therapy Oblique stereoscopic X-Ray imaging and 3D volumetric X-Ray imaging, Cone-Beam radiation therapy.
(IGPT) to cancer patients. IGPT relies on fluoroscopy allow accurate patient position Computed Tomography (CBCT), can be With the advanced imaging technologies
high-resolution and high-sensitivity X-Ray verification and monitoring. directly acquired in the treatment room built into ProteusONE, clinical users can
digital imaging systems that provide Fluoroscopy is an imaging technique that at isocenter. It can then be compared now apply similar advanced positioning
low-dose stereoscopic and 3D imaging in produces a real-time x-ray video of internal with treatment planning CT for patient and Quality Assurance protocols as those
various geometrical arrangements. body structures. The system enables the position verification and anatomical used in their Image-Guided Radiation
The advanced imaging technologies medical staff to observe the position of the modification assessment. Therapy (IGRT) practice.
integrated in ProteusONE ensure quick tumor relative to the treatment target area Advanced acquisition software, shading IBA’s ProteusONE brings the
and accurate patient position verification during treatment. For clinical indications correction, accelerated inline and offline advantages of:
by comparison with diagnostic CT imaged that are sensitive to movements of the image reconstruction algorithms support — Acquiring CBCT image in room and
during the treatment planning process. patient’s organs, fluoroscopy enables direct high-speed, high-resolution, uniform and at isocenter.
intra-fraction motion monitoring. low-dose CBCT. — Ensuring accurate patient positioning
CBCT offers excellent soft-tissue contrast, during treatment.
providing much more information than — Enabling the detection of anatomic
is the IBA imaging platform. It is part of IBA’s integrated a conventional stereoscopic alignment modifications within the patient along
proton therapy software suite, adapt Treatment Suite. It incorporates image-guidance system, and allowing more accurate patient the radiological path.
features such as 3D CBCT and stereoscopic X-Ray imaging for highly accurate patient
treatment, as well as tight integration with adapt deliver. An open architecture and
programmable workflow configurability builds a solid foundation for the development of
future proton specific image-guided solutions.
* Fluoroscopy is
CE marked.
IBA Proteus ONE // 8
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A DESIGN
INSPIRED BY
CLINICAL CARE
Working with clinicians and nurses in the
development of proton therapy worldwide
over the last 25 years has led IBA to
understand that successful treatment
does not just depend upon the successful
application of proton beam physics. The
everyday treatment experience is also
important — for the patient and clinician.
ProteusONE is designed to enhance the
patient experience by fostering a soothing
environment. At the same time, all care
has been taken to facilitate medical staff
daily practice.
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TURNING HEALTHCARE
OPTIMIZED STAFF EXPERIENCE INTO HUMAN CARE
BENEFITS OF AMBIENT EXPERIENCE
—F
or the patients and families:
• Reduced anxiety and
increased comfort.
• Higher patient satisfaction.
—F
or the staff:
• Increased working comfort.
• Better patient interaction.
• Higher job effectiveness with improved
staff experience and satisfaction.
—F
or the hospital management:
While focusing on clinical efficiency • Improved workflow and throughput.
and interoperability, ProteusONE also • Improved patient satisfaction leading to
incorporates environmental features to word-of-mouth endorsement.
help keep patients relaxed and comfortable • Attracting and retaining highly
during imaging and treatment. trained clinical staff and reducing
Based on insights from proton patients, overhead costs.
healthcare staff and experts, Philips
Healthcare and IBA integrated a solution
that improves the overall patient and staff
experience; turning a cold, impersonal
environment into one that comforts and
reassures.
Philips received the “International Red
OPEN TREATMENT ENCLOSURE staff as the gantry rotates around the Dot Award : Product design 2014” for the
isocenter (220°). The GRF ensures staff Ambient Experience associated to the
ProteusONE is designed with an open
safety during clinical operations, allowing ProteusONE.
treatment enclosure. It allows the
them to focus on their core tasks and tend
physicians and nurses to have easy Acknowledged as the best quality
to patient wellbeing.
access to the patient during positioning, and groundbreaking design, Ambient
imaging and treatment. This facilitates IN-ROOM IMAGING CONTROL Experience helps enhance the overall
patient care and comfort, and improves experience for oncology patients and staff. AMBIENT EXPERIENCE IN FIGURES*
ProteusONE permits radiation therapists
positioning procedures especially during — 76% increase in staff satisfaction
and clinicians to access and control
non-coplanar treatments. —4 % overall decrease in
patient imaging from inside the treatment
procedure duration
GANTRY ROLLING FLOOR (GRF) room. This permits improved patient care,
— 6% overall patient increase
greater ease of use and efficient patient
Thanks to the highly functional design of * Philips installed base survey “What do our In partnership with
positioning.
our Gantry Rolling Floor (GRF), the patient customers say”, 100 customers interviewed,
27 countries (excl.NA) in September 2011.
remains very accessible to the treatment
IBA Proteus ONE // 12
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PROTON
THERAPY
MADE COMPACT WHEN SIZE MATTERS
Through the development of proton In many areas, size matters. This is COMPACT
SYNCHRO-CYCLOTRON
therapy projects worldwide with many particularly true in a high-tech medical
different clinical institutions, IBA has facility where every square foot
learned that the biggest challenge is is invaluable. There is a common
neither advancing this leading-edge misconception that proton therapy requires
technology, nor convincing clinicians 220° COMPACT GANTRY
a large — and costly — facility in which TREATMENT ROOM
of its clinical effectiveness. The biggest to operate. As a consequence, too many
challenge is making this vital technology facility executives look at the space and
accessible to more cancer patients around capital they have available and quickly
the world. deem a proton center to be impossible.
This is the challenge that IBA has taken on.
The IBA team has worked relentlessly to
ProteusONE is our response — a proton prove this belief to be false. 220° OF TREATMENT FREEDOM
therapy system that is smaller, more FOR IMPROVED PATIENT AND
affordable, easier to install, easier to The result is ProteusONE: a proton therapy
solution with a footprint limited to the size STAFF EXPERIENCE
operate and ultimately easier to finance.
of two typical linac vaults. IBA offers the first compact gantry on
With ProteusONE, the power of protons is
the market that extends the treatment
possible for more patients worldwide.
COMPACT ACCELERATION WITH MINIMAL angle to 220°. In doing so, your clinicians
NEUTRON DOSE benefit from 220° of treatment freedom
Acceleration of the proton beam in and uncompromised treatment options.
ProteusONE is performed by IBA’s The open treatment enclosure allows
specially designed Superconducting physicians and nurses to have easy
Synchro-Cyclotron*. This technology access to the patient in treatment position.
reduces the accelerator weight and This facilitates patient care and comfort,
energy consumption by a factor of four. and improves positioning procedures
especially during non-coplanar treatments.
In order to ensure the safest treatment
at all time, the scanning controller The IBA 220° Compact Gantry provides the
performs 1 million measurements per perfect equilibrium associating the strength,
second, allowing to take 60,000 safety reliability and speed in a compact and
decisions per second. patient-friendly treatment solution.
Our compact accelerator is mounted The IBA Open Compact Gantry Treatment
outside of the treatment room which Room combines a compact gantry design
* IBA’s Superconducting
dramatically reduces neutron exposure. with the following advantages: Synchro-Cyclotron,
S2C2, is under
—O ptimized access and comfort for development. The
On average, it releases 7 times less
patients and staff. marketing approval will
neutron dose to the surrounding be subject to review by
— Accurate patient positioning systems. competent authorities
healthy tissues compared to a (FDA, Notified bodies,
—R educed cost and shorter et al…).
Scattering Gantry Mounted accelerator**.
installation time.
** Based on Monte Carlo
Simulations.
IBA Proteus ONE // 14
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LEADING INSTITUTIONS HAVE
ALREADY CHOSEN IBA. JOIN THEM
TO DEVELOP THE FUTURE OF
CANCER CARE TOGETHER
STAY FOCUSED ON PATIENT CARE,
OPERATION AND MAINTENANCE SERVICES
WE CAN RUN THE SYSTEM FOR YOU IN A NUTSHELL
Our experience installing proton systems at With the largest team of proton experts
more than half of the clinical proton therapy around the world, you can have access
centers worldwide has led us to understand to our qualified field support team at
the worries and clinical complexities any time, day and night. In addition
that arise when treating cancer. to personalized support, other key
Our commitment is to ensure your clinical services are provided:
success by providing reliable systems — 24/7 remote support service,
with the highest availability possible — online or over the phone, is an
over 95% uptime. The dependability and important component to keep your
reliability of IBA proton systems means you equipment’s high uptime.
can schedule patient treatments — and — A team of IBA trained specialists
necessary clinical staff — with confidence. will operate the system onsite
To date, being part of the IBA proton to ensure the highest level of
therapy client network and benefiting availability for clinical treatment.
from our technical expertise has helped — In case of emergency, we can
centers around the world to treat over deliver spare parts the same
25,000 cancer patients worldwide. day via our extensive spare parts
worldwide network with hubs in
Your team can focus on the clinical aspects
America, Asia and Europe.
of cancer care while IBA’s team keeps
— Because technology changes
your proton therapy system running at top
quickly, IBA develops both update
performance and meets the highest safety
and upgrade packages tailored
and reliability standards.
to your center’s configuration and
training programs to increase your
Lane R Rosen MD, Director of
team’s efficiency.
Radiation Oncology, Willis Knighton
NEW SERVICE FEATURES INCLUDE: Cancer Center, tells us about
— Remote Service Connections to ProteusONE installation processes :
proton therapy accelerator systems;
“IBA has placed staff locally to
— Worldwide Computerized
assure the process remains fluid.
Maintenance Management
They have demonstrated that they can
Systems.
efficiently deliver this support within
our hospital budget.
We are confident that IBA will assist
with the operation and maintenance
of our facility in the same manner in
which they have behaved thus far.”
IBA Proteus ONE // 16
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®IBA HAS DESIGNED AND INSTALLED
THE MAJORITY OF CLINICALLY
OPERATING PROTON THERAPY
CENTERS IN THE WORLD.
NORTH AMERICA NETWORK EUROPE NETWORK ASIA NETWORK
4 3 3 4 4 4 3
ROOMS ROOMS ROOMS ROOMS ROOMS ROOMS ROOMS
CDH PROTON THERAPY THE PROTON THERAPY CENTER LLC MASSACHUSETTS GENERAL HOSPITAL UNIVERSITY OF FLORIDA WESTDEUTSCHES PROTON THERAPY CENTER NATIONAL CANCER CENTER
CENTER, A PROCURE CENTER (TPTC) PROVISION HEALTHCARE BURR PROTON THERAPY CENTER PROTON THERAPY INSTITUTE PROTONENTHERAPIEZENTRUM CZECH S.R.O. Ilsan, Korea
Warrenville, IL, USA Knoxville, TN, USA Boston, MA, USA Jacksonville, FL, USA ESSEN (WPE) Prague, Czech Republic Treating since 2007
Treating since 2010 Treating since 2014 Treating since 2001 Treating since 2006 Essen, Germany Treating since 2012
3
5 4 3 Treating since 2013 ROOMS
ROOMS
4
ROOMS ROOMS ROOMS
2 2
ROOMS ROOMS
APOLLO
UNIVERSITY OF PENNSYLVANIA PROCURE PROTON THERAPY SCCA PROTON THERAPY TEXAS CENTER PROTON THERAPY CENTER
HEALTH SYSTEM ROBERTS CENTER IN OKLAHOMA CITY A PROCURE CENTER FOR PROTON THERAPY AZIENDA PROVINCIALE PER I CENTRE DE PROTONTHÉRAPIE Chennai, India
PROTON THERAPY CENTER Oklahoma City, OK, USA Seattle, WA, USA Dallas, TX, USA SERVIZI SANITARI (APSS) DE I’INSTITUT CURIE Opening in 2016
Philadelphia, PA, USA Treating since 2009 Treating since 2013 Opening in 2015 Trento, Italy Paris (Orsay), France
Treating since 2009
2
Opening in 2014 Treating since 2009 ROOMS
1 4
5 ROOM ROOMS 1 2
ROOMS ROOM ROOMS
WANJIE
WILLIS-KNIGHTON PROCURE PROTON PROTON THERAPY CENTER
HAMPTON UNIVERSITY CENTRE ANTOINE SKANDIONKLINIKEN Zibo, China
CANCER CENTER THERAPY CENTER
PROTON THERAPY INSTITUTE LACASSAGNE Uppsala, Sweden Treating since 2004
Shreveport, LA, USA Somerset, NJ, USA
Hampton, VA, USA Opening in 2014 Treating since 2012 Nice, France Opening in 2015
Treating since 2010 Opening in 2015
1
ROOM
2 1
ROOMS ROOM
CHC TAIPEI
PROTON THERAPY CENTER
BRONOWICE CYCLOTRON UNIVERSITATKLINIKUM
Taipei, Taiwan
CENTER CARL GUSTAV CARUS Opening in 2016
Kraków, Poland Dresden, Germany
Treating since 2013 Opening in 2014 1
ROOM
4
ROOMS
NATIONAL
FEDERAL HIGH-TECH PROTON THERAPY CENTER
MEDICAL CENTER Japan
Opening in 2017
Dimitrovgrad, Russia, Europe
Opening in 2015 1
ROOM
COMPACT
PROTON THERAPY CENTER
Proteus®PLUS Japan
Opening in 2017
Proteus®ONE
This map has been last updated in August 2014.
IBA Proteus ONE // 18
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®CONTACT US
AMERICAS While all care has been taken to ensure
Toll-free: 1 877 IBA 4 PBT that the information contained in this
T +1 904 491 6080 publication is correct, we accept no
responsibility for any inaccuracy and
EUROPE, MIDDLE EAST AND AFRICA reserve the right to modify this information.
T +32 10 203 342 Technical specifications are based on
F +32 10 475 923 standard operating conditions and may be
subject to variations.
RUSSIA & CIS Pictures and illustrations are
T/F +7 495 648 69 00 not contractual.
E-mail: info@iba-russia.ru
ProteusONE is the brand name of a new
ASIA PACIFIC configuration of the Proteus 235 including
T +86 10 8080 9186 some new developments subject to review
by competent authorities before marketing.
Empath is a registered trademark of IBA
Particle Therapy.
E-mail: info-pt@iba-group.com AdaPT insight is the brand name of
Visit us online at: the I2C software suite applicable to the
www.iba-proteusone.com IBA Proton Therapy solutions.
IBA, a Belgian company, is listed on
the pan-European stock exchange
EURONEXT and its annual reports can be
downloaded on the website:
www.iba-worldwide.com
Published by IBA S.A.,
Chemin du Cyclotron, 3
1348 Louvain-la-Neuve, Belgium.
This brochure is printed on ECF woodfree
uncoated paper. It was produced with
plants that comply with ISO 14001,
the environmental management standard.
IBA Proteus ONE // 20
®IBA Group | 2014 | IBAL01/4024 | ProteusONE | August 2014
IBA, THE HIGH WAY TO PROTON THERAPY
In proton therapy, the development of practical and patient-centered
solutions is only possible through constant collaboration, open engagement
and shared research objectives. With more than 25 years of experience
designing and developing proton therapy systems across the globe, IBA
has grown a strong and vital community of proton therapy professionals.
Together, this unprecedented community - of clinical leaders and
distinguished technological experts - is advancing proton beam technology
and clinical innovations.
By entering the IBA Proteus community:
— Your clinicians and researchers will leverage the latest outcome-
driven practices being advanced on a common technological
platform. Sharing with a community of experienced clinical proton
beam users will give them the capacity of your team to be trained
with the utmost care and the highest standards of quality.
— Your
project management team will be able to collaborate with
the world’s most experienced team of proton therapy experts
(600+), cutting-edge technology and robust processes in system
installation and operation.
— Your
executive team will leverage the know-how and clinical
understanding built on 25+ projects and 25,000+ patients treated to
secure the institutions’ investment.
Together with our people, by sharing our passion for innovation and patient
care, you can take comfortably the highway to the future of cancer care.
The IBA Proteus Community includes among others Massachusetts General Hospital
Burr Proton Therapy Center, ProCure Proton Therapy Centers, University of Florida
Proton Therapy Institute, University of Pennsylvania Health System Roberts Proton
Therapy Center… in North America; or Centre de Protonthérapie Orsay de I’Institut Curie,
Universitätsklinikum Carl Gustav Carus …in Europe; and Korean National Cancer Center,
Appolo Health Group… in Asia.
VISIT US ONLINE AT:
www.iba-protontherapy.com
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