Aromatherapy in Obstetrics: A Critical Review of the Literature

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CLINICAL OBSTETRICS AND GYNECOLOGY
                                                            Volume 00, Number 00, 000–000
                                                            Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

                            Aromatherapy in
                            Obstetrics: A Critical
                            Review of the
                            Literature
                            ANNA C. BERTONE, MPH,
                            and REBECCA L. DEKKER, PhD, RN
                            Evidence Based Birth, Lexington, Kentucky

Abstract: Aromatherapy is the use of highly concen-             aromatic essential oils from plants have
trated aromatic plant oils administered in various              been used as perfumes and medicines for
ways for a wide range of therapeutic indications.
The purpose of this review is to present an overview            over 3500 years. René-Maurice Gattefossé,
of the evidence on aromatherapy during the perinatal            a French chemist and perfumer, coined the
period. There is research on the prenatal use of                term, perhaps to distinguish between essen-
aromatherapy to treat nausea and vomiting, reduce               tial oils used in perfumery versus those used
stress, and support immune function; the intrapartum            medicinally to enhance physical and mental
use of aromatherapy for labor pain/anxiety and labor
progress; and the postpartum use of aromatherapy for            wellbeing.1 Unlike herbal medicine, which
postcesarean symptoms, perineal trauma, sleep, and              uses whole plants to achieve a therapeutic
symptoms of depression and anxiety. Overall, the                effect, essential oils used in aromatherapy
evidence suggests that aromatherapy can be adminis-             are highly concentrated extracts derived
tered safely and effectively in obstetrics.                     from plant roots, leaves, bark, seeds, and
Key words: aromatherapy, essential oils, complemen-
tary medicine, parturition, prenatal, labor pain                flowers.2 It can take many pounds/kilo-
                                                                grams of plant material to produce one
The term “aromatherapie” first came into                        bottle of essential oil. The concentrated
use in the early 20th century, although                         chemicals in the oils give them different
                                                                properties (ie, relaxing, stimulating, pain-
Correspondence: Rebecca L. Dekker, PhD, RN, Evi-                relieving) that can be harnessed for a
dence Based Birth, PO Box 4962, Lexington, KY.                  beneficial effect.
E-mail: info@evidencebasedbirth.com
                                                                   Aromatherapy may help with pain
Supplemental Digital Content is available for this              management by activating thought and
article. Direct URL citations appear in the printed text
and are provided in the HTML and PDF versions of                mental processes that interrupt the trans-
this article on the journal’s website, www.clinicalobgyn.       mission of pain signals, taking attention
com.                                                            away from a painful sensation, stimulat-
A.C.B. is a research consultant with Evidence Based             ing the release of endorphins, and helping
Birth. R.L.D. is the founder and CEO of Evidence
Based Birth headquartered in Lexington, KY.                     to reframe thoughts about uncomfortable

CLINICAL OBSTETRICS AND GYNECOLOGY                          /   VOLUME 00          /    NUMBER 00         /     ’’ 2021

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2      Bertone and Dekker

sensations. The theory behind this over-                     CAM therapies, such as aromatherapy,
arching pain management modality is                      deserve attention in obstetrics because
known as “Control of the higher centers                  they have become increasingly popular
of the central nervous system,” or CNSc.3                over recent decades. Studies report prev-
Other pain relief strategies within the                  alence rates of CAM use in pregnancy
CNSc theoretical model include medita-                   ranging between 1% and 87%, with most
tion, yoga, hypnotherapy, continuous                     estimates ranging between 20% and 60%.6
support, breathing/relaxation techniques,                Some of this use is self-prescribed, and
and music. In addition to the CNSc                       some is due to health care providers
mechanism, aromatherapy may also work                    prescribing or offering advice on CAM
by reducing cortisol and increasing sero-                therapies. A survey of 135 health care
tonin levels.4                                           providers (midwives, obstetricians, anes-
   Researchers have theorized that aroma-                thetists) in Northeast Scotland found that
therapy exposes people to scent molecules                a third of respondents had recommended
that attach to olfactory receptors in the                the use of CAM therapy to pregnant
nasal cavity. Electrical signals are then                clients, and of these, 24% had recom-
transmitted to the brain by olfactory sensory            mended aromatherapy.7 In Australia, a
neurons. These electrical signals stimulate              large cross-sectional questionnaire con-
the limbic system (the part of the brain that            ducted in 2009 surveyed a nationally
deals with emotions and memories), and by                representative sample of 8200 women
doing so aromatherapy can decrease anxiety               about self-prescribed use of aromather-
and reduce pain perception.4 In this regard,             apy oils. About 10% (804) of the survey
choosing a fragrance that is personally                  respondents were pregnant at the time of
appealing may offer individualized benefits.             the survey, and 15.2% of these reported
In addition, models have demonstrated that               that they self-prescribed aromatherapy
the components of essential oils (when                   oils during pregnancy.8 However, despite
inhaled or absorbed through the skin) can                its common use in the perinatal popula-
enter the systemic circulation and cross the             tion, some obstetric care providers remain
blood-brain barrier.5                                    unaware of the research evidence on
   Examining complementary and alterna-                  aromatherapy. Therefore, this narrative
tive medicine (CAM) therapies, such as                   review provides a critical synthesis of the
aromatherapy, is important because their                 best available evidence in the current
application can result in significant maternal           literature (from within the last 10 y) on
benefits throughout the peripartum period.               perinatal effects of aromatherapy.
Beneficial effects may be due in part to the
receipt of individualized, woman-centered
care, as this is a philosophy of care inherent           Methods
to all CAM modalities. CAM therapies                     We performed a search on PubMed using
embrace the concept of “holism,” in which                the key words aromatherapy AND (obstet-
the individual is viewed as a whole person               rics or pregnancy or prenatal or labor or
with interlinking physical, mental, and spi-             delivery or postpartum). Results were re-
ritual conditions. Aromatherapy is viewed                trieved from within the last 10 years up to
as a holistic therapy, especially when ad-               October 2020. This review was limited to
ministered with a manual modality such as                studies published in the English language,
massage. The manual effects of the mas-                  and we excluded research studies on aro-
sage, when combined with the psychoemo-                  matherapy and breastfeeding. The search
tional effects of the essential oils, can create         revealed 135 results. Criteria for the inclu-
a sense of wellbeing, thus affecting body,               sion of studies were full-length, peer-re-
mind, and spirit.1                                       viewed meta-analyses, systematic reviews,

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Aromatherapy in Obstetrics               3

randomized controlled trials (RCTs), and               history of gastrointestinal disease. Studies
quasi-experimental trials that evaluated the           were restricted to only those with the
effects of aromatherapy during the prenatal,           strongest methodology per Jadad criteria
intrapartum, or postpartum periods. We                 (a score of 3 or higher of 5). The Jadad
identified 36 studies that met our criteria            score is a tool used to assess the methodo-
for inclusion (10 meta-analyses/systematic             logical quality of controlled trials between
reviews and 26 RCTs/quasi-experimental                 0 (very poor) and 5 (rigorous).
trials). A review of this literature will be               Of the 21 papers included in this review
discussed in the following sections.                   of complementary medicine methods, 2
                                                       assessed peppermint aromatherapy (Ja-
                                                       dad scores of 4 and 5), and one assessed
Results                                                lemon aromatherapy (Jadad score of 5).
                                                           The first of the 2 studies on peppermint
DESCRIPTION OF STUDIES                                 aromatherapy was a double-blinded study
We formulated search terms and screened                by Pasha et al24 that randomly assigned 60
abstracts for all studies meeting the inclu-           pregnant participants with nausea and vom-
sion criteria. Altogether, this review dis-            iting to peppermint essential oil or normal
cusses 1 systematic review9 on nausea and              saline placebo. Women in the peppermint
vomiting during pregnancy; 2 RCTs10,11 on              group slept for 4 consecutive nights with a
stress reduction and immune function dur-              bowl of water containing 4 drops of pure
ing pregnancy; 4 meta-analyses,2,12–14 2               peppermint essential oil placed on the floor
systematic reviews15,16 and 1 quasi-experi-            near their beds, while those in the control
mental trial17 on labor pain/anxiety and               group used 4 drops of saline. The research-
labor progress/outcomes; 1 meta-analysis18             ers mentioned that they attempted to blind
and 2 RCTs19,20 on postcesarean symptoms;              mothers in the control group by pouring
and 2 systematic reviews21,22 and 1 RCT23              some peppermint oil into the inner parts of
on perineal trauma, postpartum sleep, and              the saline container’s lid. The Visual Analog
symptoms of depression and anxiety. Sup-               Scale (VAS) was used to assess the severity
plementary Table 1 (Supplemental Digital               of nausea, and the frequency of vomiting
Content, http://links.lww.com/GRF/A26)                 was recorded before, during, and after the
details notable essential oils that demon-             intervention. There was a decreasing trend
strated a significant effect for each indica-          in the peppermint group that did not reach
tion compared to control in randomized                 statistical significance, possibly due to the
trials.                                                small sample size. During the 4 days of
                                                       intervention, the mean of nausea intensity
PRENATAL USE OF AROMATHERAPY                           was 3.50 ± 1.95 and 4.38 ± 2.18 in the pep-
There is research from RCTs on the                     permint and saline groups, respectively
prenatal use of aromatherapy for nausea                (P = 0.140). The mean of vomiting intensity
and vomiting during pregnancy, as well as              during the 4-day intervention was
for stress reduction and immune function.              2.23 ± 1.88 in the peppermint group and
                                                       2.55 ± 2.55 in the saline group (P = 0.577).
Nausea and Vomiting                                        Joulaeerad et al25 carried out a single-
We found a 2018 systematic review of                   blinded study comparing peppermint oil to
RCTs that investigated different comple-               almond oil (placebo) and similarly found no
mentary medicine methods used to treat                 significant effect on the severity of nausea
nausea and vomiting during pregnancy.9                 and vomiting during pregnancy. A total of
Participants had experienced nausea with               56 participants, all between 6 and 20 weeks
or without vomiting, were overall healthy,             of gestation with mild to moderate nausea
with a single fetus, and without any                   and vomiting, were randomly assigned to

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4      Bertone and Dekker

peppermint oil or placebo. For 4 days, they              from 16 to 36 weeks gestation to determine
were asked to drop 5 drops onto a cotton                 the effects of aromatherapy massage on
ball, hold it 1 cm below the nose, and take 3            participants’ stress levels and immune
deep breaths through the nose. They were                 function.10 Women with high-risk pregnan-
asked to repeat this 4 times per day when                cies were excluded (ie, multiple gestations,
they felt nauseous. Nausea and vomiting                  fetal growth restriction, or other abnormal-
scores were assessed as a single measure                 ities) as well as those with a history of severe
with the Pregnancy Unique Quantification                 illness (including depression) or reported use
of Emesis/Nausea questionnaire. The results              of medications with the potential for abuse.
showed no difference in the severity of                  The intervention group received routine
nausea and vomiting between placebo and                  prenatal care plus 70 minutes of aromather-
intervention groups during the 4-day inter-              apy massage every other week for a total of
vention period. At the end of the 4 days,                10 sessions, while the control group received
mean scores were 5.18 ± 1.90 and                         only routine prenatal care (which did not
5.82 ± 2.14 in the peppermint oil and place-             include aromatherapy or massage). A certi-
bo groups, respectively (P = 0.227).                     fied aromatherapist delivered the massage
   Yavari Kia et al26 found a significant                treatment using a combination of effleurage,
reduction in nausea and vomiting during                  friction, petrissage, and vibration applied
pregnancy with lemon aromatherapy                        with moderate pressure to the head, neck,
compared with placebo. In this double-                   shoulders, arms, waist, back, legs, and feet.
blinded trial, 100 participants with nausea              The massage oil consisted of 2% lavender
and vomiting during pregnancy were ran-                  (Lavandula angustifolia) essential oil; ∼30
domly assigned to a lemon essential oil                  mL was used for each massage.
(Citrus lemon) or placebo (almond oil                        The study authors used salivary cortisol
combined with carrots to match the color                 (μg/dL) as an indicator of stress, and
of lemon oil). The participants had single-              salivary immunoglobulin (Ig) A (μg/mL)
ton pregnancies between 6 and 16 weeks                   as an indicator of immune function. Saliva
gestation, with no major medical prob-                   samples were collected from participants in
lems. They were taught to put 2 drops                    both groups before and after the interven-
onto a cotton ball, hold it 3 cm below the               tion group received aromatherapy massage
nose, and take 3 deep breaths through                    treatment. Analysis of the saliva samples
the nose whenever they felt nauseated.                   revealed that participants in the aroma-
The procedure could be repeated                          therapy massage group had lower salivary
5 minutes later. Nausea and vomiting                     cortisol (P < 0.001) and higher IgA
scores were assessed with the Pregnancy                  (P < 0.001) levels immediately after each
Unique Quantification of Emesis/Nausea                   treatment compared with those in the
questionnaire. The mean scores of nausea                 control group. In the control group, the
and vomiting were significantly lower                    pretest and posttest salivary cortisol and
with lemon aromatherapy on the second                    IgA levels were similar at each time point.
[mean deviation (MD): −1.06 (−1.94 to                    Aromatherapy massage also showed sig-
−0.19), P = 0.017] and fourth [MD: −1.00                 nificant long-term effects in salivary IgA
(−1.95 to −0.05), P = 0.039] days of treat-              levels; the pretest levels at 32 (P = 0.002)
ment. The researchers reported no ad-                    and 36 (P < 0.001) weeks gestation were
verse effects from the treatment and                     higher than the pretest IgA levels at 16
concluded that the results were promising.               weeks (baseline).
                                                             In this study, they found no evidence of
Stress Reduction and Immune Function                     long-term effects of aromatherapy mas-
In the first study of its kind, researchers              sage on salivary cortisol levels. This could
longitudinally followed 52 healthy women                 be due to a physiological increase in stress

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Aromatherapy in Obstetrics               5

as the pregnancy progresses, particularly              (P < 0.05) after the intervention. The in-
after ∼32 weeks gestation. In the control              tragroup comparison suggests that aro-
group, there was a significant increase in             matherapy inhalation with essential oils
pretest salivary cortisol levels between 16            high in linalool and linalyl acetate could
and 36 weeks. The frequency of aroma-                  significantly decrease heart rates and im-
therapy massage may need to be increased               prove anxiety and anger for pregnant
after 32 weeks gestation to once or twice a            women. There were, however, no differ-
week to overcome rising stress levels                  ences observed between intervention and
during pregnancy.10 The findings suggest               control groups, so further research is
that prenatal aromatherapy massage                     required. There is also a need to study
could immediately relieve stress and en-               these effects over longer periods of time.
hance long-term immune function. How-                  In this study, participants were only
ever, this study was limited by the                    assessed 5 minutes postintervention.
inability to separate the effects of aroma-
therapy from those of massage, and blind-              INTRAPARTUM USE OF
ing was not possible given the nature of               AROMATHERAPY
the intervention.                                      We found 2 areas of research in which there
   An earlier, much smaller RCT also                   is evidence from RCTs: labor pain and
assessed the effects of aromatherapy on                anxiety, and labor progress and outcomes.
stress during pregnancy.11 This study used
the Profile of Mood States (POMS) ques-                Labor Pain and Anxiety
tionnaire that measures mood states by 6               Smith et al2 conducted the first systematic
scales and heart rate measurements to                  review and meta-analysis specifically on
examine the physical and psychological                 aromatherapy for pain management in
effects of aromatherapy inhalation. A total            labor and concluded there is a lack of
of 13 pregnant women in week 28 of a low-              research evaluating the role of aromather-
risk pregnancy were assigned to interven-              apy for labor pain management. This
tion (n = 7) or control (n = 6). Participants          Cochrane review included 2 RCTs with
were asked to choose one essential oil out             535 participants. In one trial, women in
of lavender (L. angustifolia), petitgrain              the experimental group could choose
[Citrus aurantium (Fe)], and bergamot                  from 5 essential oils: Roman chamomile
(C. aurantium). All of these essential oils            (Chamaemelum nobile), clary sage (Salvia
are high in linalool and linalyl acetate,              sclarea), frankincense (Boswellia carteri),
which are thought to have relaxing effects.            lavender (Lavandula augustifolium), and
   Pregnant women in both groups filled                mandarin (Citrus reticulata), while the
out the POMS and then rested in a seated               control group received standard care on-
position for 10 minutes while wearing a                ly. In the other trial, the experimental
portable heart rate monitor. During the                group was assigned to the essential oil of
second half of the 10-minute session,                  ginger and the control group received
aromatherapy inhalation was given to                   another essential oil (lemongrass). The
those in the intervention group. All study             trials found no difference between groups
subjects were aware of their group assign-             in pain intensity or epidural use.
ment. In the intervention group, the re-                  A more recent meta-analysis and sys-
searchers observed improvements in the                 tematic review by Lakhan et al12 refer-
Tension-Anxiety Score (P < 0.05) and                   enced the above-mentioned Cochrane
the Anger-Hostility Score (P < 0.05) of                findings and included 2 new clinical trials.
the POMS after aromatherapy inhalation                 The first of these (n = 160) found lower
treatment. There was also an intragroup                mean pain intensity with lavender com-
increase in parasympathetic nerve activity             pared with control at 30 and 60 minutes

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6      Bertone and Dekker

after the intervention (P < 0.001).27 The                damascena), bitter orange (C. aurantium),
second new trial (n = 126) also found                    lavender (L. angustifolia), geranium (Pelar-
reduced pain severity following aroma-                   gonium graveolens), and sweet orange (Cit-
therapy with a bitter orange (C. auranti-                rus sinesis). One study had participants in
um) at 3 to 4 cm (P < 0.05), 5 to 7 cm                   the experimental group select from laven-
(P < 0.05), and 8 to 10 cm (P < 0.05)                    der, geranium rose, citrus, and jasmine,
dilatations compared with control.28 Both                based on their personal preference. Another
of these studies (Kaviani and colleagues;                study with 2 experimental groups assigned
Namazi and colleagues) were included in                  participants to jasmine (Jasminum offici-
the following 2 meta-analyses.                           nale) or salvia (Salvia officinalis).
   A 2020 systematic review and meta-                       Aromatherapy was shown to reduce
analysis of 8 RCTs and 1 quasi-experimen-                pain in latent (cervical dilatation of 3 to
tal study evaluated the effects of aroma-                4 cm), early active (cervical dilation 5 to 7
therapy on anxiety and pain during the first             cm), and late active (cervical dilation 8 to
stage of labor in nulliparous participants.13            10 cm) phases of first-stage labor com-
Full-text trials published in English before             pared with control. The corresponding
January 2019 were eligible for inclusion.                VAS score reductions were MD: −1.88
Study subjects were low-risk primigravida                (−2.98 to −0.78), P = 0.0008 in latent
with a singleton, cephalic pregnancy at                  labor (5 RCTs); MD: −1.78 (−2.83 to
term (gestational age over 37 wk) in spon-               −0.72), P = 0.001 in early active labor (4
taneous first-stage labor (defined as > 3                RCTs); and MD: −1.72 (−2.69 to −0.76),
contractions in 10 min with cervical                     P = 0.0004 in late active labor (4 RCTs).
change). The authors used VAS to measure                 It is worth noting that although aroma-
pain from 0 (no pain) to 10 (worst possible              therapy resulted in significantly lower
pain). To measure anxiety, they used the                 pain scores compared with control, mean
first 20 questions of the Spielberger’s State-           pain scores were still at moderate to
Trait Anxiety Inventory questionnaire,                   severe levels in both groups (∼6.9 vs. 8.6
with possible scores between 20 (no anxi-                in the late active phase). Epidural analge-
ety) and 80 (highest possible anxiety).                  sia was not typically available or used by
Trials were excluded that used different                 participants in these studies; therefore,
case selection criteria and measurement                  more research is required to assess aro-
methods.                                                 matherapy as an addition to pharmaco-
   The 9 included trials were published                  logical analgesia.13,29 High heterogeneity
between 2010 and 2018; 7 were published                  was observed among the studies in each
in Iran, 1 in Taiwan, and 1 in Thailand. The             comparison, which could indicate effect
studies used different methods of adminis-               variation from different essential oils and
tering the aromatherapy intervention. In 5               methods of administering aromatherapy.
RCTs it was given via inhalation, while the              Subgroup analysis of lavender inhalation
control group received distilled water place-            (2 RCTs) found a significant reduction in
bo (4 studies) or usual care (1 study). In 3             pain in the latent phase with moderate
RCTs the experimental group received                     heterogeneity; however, the effect on
drops of essential oils applied to gauzes                early active and late active labor was not
attached to their neck collars, while partic-            statistically significant. An analysis of 4
ipants in the control groups received gauzes             trials did not find a significant difference
with drops of normal saline. Finally, the                between baseline pain scores (on admis-
quasi-experimental study compared with                   sion) in the experimental group and pain
massage with essential oil to massage with               scores after the aromatherapy interven-
carrier oils alone. The essential oils admin-            tion [MD: −0.67 (−2.49 to 1.16),
istered in the studies were rose (Rosa                   P = 0.47]. It may be that the pain-relieving

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Aromatherapy in Obstetrics               7

effect before versus after aromatherapy                   Two systematic reviews in the last few
was masked by an inherent increase in                  years have assessed the effectiveness of
pain intensity with the progression of                 aromatherapy at managing labor pain
active labor, especially since epidurals               and anxiety. Tabatabaeichehr and
were not typically utilized.                           Mortazavi15 evaluated 33 randomized
   Aromatherapy also reduced partici-                  trials conducted in English and Persian.
pants’ anxiety during latent labor com-                Twenty-seven of the 33 studies were
pared with control [MD: −9.29 (−15.88 to               carried out in Iran. Aromatherapy was
−2.69), P = 0.006]. As with pain scores,               administered with inhalation, massage,
the intragroup results comparing anxiety               footbath, birthing pool, acupressure, and
before and after aromatherapy did not                  compress. The essential oil most com-
find a significant effect [MD: −5.64                   monly used in the studies was lavender,
(−16.00 to 4.71), P = 0.29].                           either alone or in combination with other
   Another meta-analysis by Chen et al14               essential oils. Other essential oils used in
also found a significant reduction in pain             the included studies were geranium,
scores with aromatherapy during labor.                 frankincense, rose, chamomile, bitter or-
Lavender was the most common oil used                  ange, jasmine, sweet orange, mandarin,
in these trials. The authors conducted                 peppermint, and clove. The majority of
separate analyses of RCTs with cervical                the studies (29/33) reported that aroma-
dilation info and those without. The 6                 therapy had a significant positive effect
trials with dilation info reported a wide              on reducing labor pain and/or anxiety.
range of dilations but all included the 8 to           No serious side effects to aromatherapy
10 cm transition phase. The aromather-                 were reported in any of the studies. The
apy group reported reduced pain scores in              systematic review concluded that aroma-
the transition phase compared with the                 therapy could help in relieving maternal
control group [MD: −0.82 (−1.55 to                     anxiety and pain during labor.
−0.09), P = 0.03]. Meta-analysis of the 4                 Ghiasi et al16 reviewed 16 randomized
trials without dilation info also showed a             trials, specifically focusing on aromather-
reduction in pain scores postintervention              apy to relieve anxiety during the first
[MD: −2.01 (−3.63 to −0.39), P = 0.02].                stage of labor. Aromatherapy was admin-
   Our literature search also identified a             istered with inhalation in 12 studies and
quasi-experimental trial by Sriasih et al17            by massage in 4 studies. Lavender was the
that was too recent to be included in any of           most frequently studied oil; other oils
the meta-analyses. Participants were ran-              included rose, clary sage, geranium,
domly assigned to massage with frangipani              frankincense, chamomile, bitter orange,
(Plumeria) aromatherapy oil (n = 35) or                sweet orange, peppermint, mandarin or-
massage with virgin coconut oil as control             ange, jasmine, and clove. Of the 16
(n = 35). The massage was applied to the               studies, all but 1 study found that aroma-
back region at thoracic vertebrae 10, 11, 12,          therapy significantly lowered anxiety dur-
and lumbar 1 levels. Midwives began the                ing the first stage of labor. The systematic
massage treatment at 4 cm and continued                review recommended that aromatherapy
the massage for 5 to 6 hours until maximal             could be applied as a complementary
dilation at the end of first-stage labor.              therapy for reducing anxiety during the
Before the massage treatment, both groups              first stage of labor; however, they cited
reported pain scores on a scale of 7 to 9              the need for more methodologically rig-
(considered severe pain). After the treat-             orous studies.
ment, pain scores were significantly reduced              Overall, the available evidence suggests
to a median of 7 in the control group and 6            that aromatherapy reduces pain and anxi-
in the aromatherapy group (P < 0.001).                 ety during the first stage of labor.

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8      Bertone and Dekker

Labor Progress and Outcomes                              Postcesarean Symptoms
Six trials in the Chen et al14 meta-analysis             A Cochrane review on CAM for post-
reported a comparison of the duration of                 cesarean pain found 4 trials that exam-
the active phase of the first stage of labor.            ined the effects of aromatherapy on
The results showed that aromatherapy                     postcesarean pain.18 All 4 studies pro-
consistently reduced the duration of the                 vided pharmacological analgesia in both
active phase (h) compared with control                   the aromatherapy groups and the control
across trials [MD: −0.69 (−1.02 to −0.36),               groups. Two trials tested the effects of
P < 0.0001]. There was also a reduction in               lavender versus sham lavender or place-
the duration of the third stage (min) with               bo, 1 via mask inhalation and the other
aromatherapy [MD: −3.32 (−6.26 to                        using drops applied to cotton; 1 study
−0.38), P = 0.03]; however, high hetero-                 compared chamomile to placebo using
geneity across trials suggests other factors             drops applied to cotton; and 1 study
such as third-stage management could                     compared C. aurantium to saline, also
have influenced this outcome. The analy-                 using drops applied to cotton. Due to
sis showed a nonsignificant trend towards                differences in data collection, data from
the shorter duration of second-stage labor               all 4 studies could not be pooled for most
and shorter total duration of first-stage                of the outcomes. The Cochrane reviewers
labor (early phase, active phase, and                    found low-certainty evidence that aroma-
transition phase) with aromatherapy.                     therapy plus analgesia may slightly de-
   Aromatherapy during labor does not                    crease postcesarean pain as measured by
appear to have an effect on the risk of                  the VAS at 12 hours [MD: −2.63 (−3.48
intrapartum cesarean or newborn Apgar                    to −1.77), P < 0.00001, 3 studies] and
scores, suggesting that aromatherapy can                 24 hours [MD: −3.38 (−3.85 to −2.91),
be safely administered intrapartum. Six                  P < 0.00001, 1 study] compared with pla-
trials in the Chen et al14 meta-analysis                 cebo plus analgesia. One study found
compared the incidence of intrapartum                    lower diastolic blood pressure in the
cesarean between groups and no differ-                   aromatherapy group [MD: −3.62 mm
ences were observed [relative risk (RR):                 Hg (−6.97 to −0.27), P = 0.03], and 2
0.78 (0.48 to 1.26), P = 0.31]. Similarly,               studies found a 42% reduction in RR of
the 2 trials in Smith et al2 found no                    using additional pain medication [RR:
difference in the duration of labor, rate                0.58 (0.45 to 0.75)]. The Cochrane re-
of cesarean, or rate of assisted vaginal                 viewers found uncertain effects of aroma-
birth. Three trials in the Liao et al13 meta-            therapy on postcesarean anxiety (1 study)
analysis investigated aromatherapy’s po-                 and vital signs other than diastolic blood
tential influence on Apgar scores at 1 and               pressure. There were no data on potential
5 minutes after birth. The results did not               adverse events. Only 1 study measured
find a significant effect on Apgar scores.               patient satisfaction; the researchers found
The studies consistently showed no effect                that 90% of the aromatherapy group was
from aromatherapy on the cesarean rate                   satisfied, compared with 50% in the pla-
or Apgar score.                                          cebo group (P = 0.002).
                                                            An additional double-blind RCT on
POSTPARTUM USE OF                                        postcesarean pain published in 2019 by
AROMATHERAPY                                             Abbasijaharomi et al19 was too new to be
We found systematic reviews and                          included in the Cochrane review. Ninety
randomized controlled evidence on aro-                   mothers who gave birth by cesarean were
matherapy for use with postcesarean                      randomly assigned to aromatherapy with
symptoms, perineal trauma, sleep, and                    lavender, aromatherapy with damask
symptoms of depression and anxiety.                      rose, or control with distilled water. The

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Aromatherapy in Obstetrics               9

aromatherapy and control treatments                    Participants in all 3 groups had similar
were administered by asking the mothers                levels of nausea at baseline. The aroma-
to inhale cotton balls imbibed with 3                  therapy and placebo groups inhaled from
drops of oil or water for 30 minutes.                  a mini ziplock bag containing a cotton
Before the intervention or control, there              ball with 1 mL of peppermint spirits or
was no difference in VAS pain levels                   sterile water, respectively. They held the
between groups (P = 0.072). Five minutes               bag 2 inches under the nose and took 3
after the intervention was completed,                  slow, deep breaths. This intervention was
average pain levels were significantly low-            conducted at baseline and again 2 and
er in both aromatherapy groups com-                    5 minutes postbaseline. The nausea levels
pared with the control (damask rose:                   of participants in the peppermint spirits
4.97 ± 1.92; lavender: 5.80 ± 2.01; control:           group were significantly lower than those
6.03 ± 1.43; P = 0.042). Five-minute post-             of participants in the other 2 groups at 2
intervention pain levels were lower in the             and 5 minutes after the initial intervention
damask rose group than the lavender                    [peppermint vs. placebo at 2 min
group; however, the lavender group had                 (P < 0.001) and 5 min (P < 0.001); pepper-
a trend towards the highest pain levels at             mint vs. antimetic therapy at 2 min
baseline, which may explain why lavender               (P = 0.001) and 5 min (P = 0.003)]. Within
did not have postintervention results as               the peppermint aromatherapy group, 17
low as damask rose.                                    of the 22 participants reported no nausea
   Our literature search identified 1 small            or slight nausea at 5 minutes, while every-
RCT on aromatherapy to treat postcesar-                one in the placebo and standard care
ean nausea.20 Participants were invited to             groups still reported moderate to extreme
take part in this study if they were                   nausea or “about to vomit.” The authors
scheduled for a nonemergency cesarean,                 concluded that peppermint spirits could
English speaking, at least 18 years of age,            be a useful adjunct in the treatment of
nonsmoker, and became nauseated after                  postoperative nausea.
their cesarean. Anyone with an allergy to
peppermint or food colorings was ex-                   Perineal Trauma
cluded, as well as those diagnosed with                Tsai et al21 published a systematic review of
persistent vomiting or receiving magnesi-              15 studies evaluating the effects of aroma-
um sulfate therapy. Potential participants             therapy on a variety of postpartum out-
were told they would be randomly as-                   comes. Their paper included 5 RCTs on
signed to 1 of 3 groups: peppermint spirits            postepisiotomy pain and healing. The re-
aromatherapy (Mentha piperita), sterile                sults suggested that regular use of lavender
water placebo (mixed with green food                   inhalation and lavender added to bath-
coloring), or standard antiemetic therapy.             water may have beneficial effects on wound
The “peppermint spirits” consisted of                  healing and pain after an episiotomy. The
ethyl alcohol 82%, peppermint oil, puri-               largest study of postepisiotomy healing
fied water, and peppermint leaf extract.               included in this review was published by
   Thirty-five participants experienced                Vakillian et al.30 This study took place in
postcesarean nausea and were randomly                  Iran, where nearly all primiparous women
assigned to peppermint aromatherapy                    who give birth vaginally have an episiot-
(n = 22), placebo (n = 8), or standard                 omy. Vakillian et al30 randomly assigned
antiemetic therapy (n = 5). Baseline nau-              120 postpartum women to receive lavender
sea was assessed with a 6-point nausea                 oil (distilled in a sitz bath twice daily for 10
scale immediately before administering                 d) versus povidone-iodine wound care,
the interventions and reassessed 2 and                 which is routinely recommended for post-
5 minutes after the initial intervention.              episiotomy care in Iran. Ten days after

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10       Bertone and Dekker

entering the study, there was a trend                     scores on the individual subscales of red-
towards more people with zero pain in                     ness, edema, and discharge.
the lavender oil group (41.7% vs. 28.3%),
and fewer people with severe pain in the                  Sleep
lavender oil group (13.3% vs. 30%), but the               We found 2 systematic reviews on aro-
result was not statistically significant                  matherapy for postpartum sleep. The
(P = 0.063). Examination results from a                   Rezai-Keikhai et al’s22 review included 3
blinded midwife showed more people had                    randomized trials, while Tsai et al21 ex-
zero redness in the lavender oil group                    amined only 2 of those studies and ex-
(51.7% vs. 21.7%, P = 0.001), but there                   cluded the third because it did not test
were no differences between groups in rates               true aromatherapy. In the first study
of edema, dehiscence, or infections.                      included in the Tsai and colleagues’ re-
   We found one study that was not                        view, Keshavarz Afshar et al31 enrolled
published in the Tsai et al’s review; this                158 healthy, nondepressed mothers who
trial took place in Egypt, which also has                 were exclusively breastfeeding their in-
extremely high rates of episiotomy. In                    fants and had poor quality sleep as meas-
this RCT, Marzouk et al23 analyzed data                   ured by the Pittsburgh Sleep Quality
from 60 women who were randomly                           Index score (a scale from 0 to 21 with
assigned to aromatherapy with lavender                    higher scores indicating worse sleep qual-
or placebo with saline. The aromatherapy                  ity). During the first week, postpartum,
group was instructed to use a sitz bath                   participants randomly assigned to the
twice daily for 7 days; women were given                  aromatherapy group were instructed to
a solution of 2% lavender-thymol (1:1)                    put 4 drops of lavender oil on a cotton
dissolved in jojoba oil, and they were                    ball and place it in a container about 20
instructed to mix it with 4 L of warm                     cm away. They took 10 deep breaths, then
water. The control group followed similar                 placed the container by their pillow until
instructions but added a prepared solu-                   morning. The placebo group followed the
tion containing 10 mL of saline to the 4 L                same instructions but used a placebo oil
of warm tap water. All women received a                   instead. Eight weeks after beginning the
postpartum home visit on day 7 and week                   study protocol, sleep quality was signifi-
7 to evaluate incision healing and pain.                  cantly improved in the aromatherapy
The mean VAS pain scores were signifi-                    group (from 8.29 ± 2.12 down to
cantly lower in the aromatherapy group                    6.80 ± 2.37, P < 0.05), but not in the con-
at 7 days (2.1 ± 2.2 vs. 3.5 ± 1.9,                       trol group (8.46 ± 2.3 to 7.57 ± 1.15,
P = 0.011), and dyspareunia was more                      P > 0.05). Eight-week postintervention
severe in the placebo group (5.3 ± 2.7 vs.                sleep quality was also significantly im-
2.7 ± 1.5, P < 0.001).                                    proved in the aromatherapy group com-
   An examination of analgesic use from                   pared with the control group (6.80 ± 2.37
the first 3 days postpartum revealed more                 vs. 7.60 ± 1.15, P = 0.033).
analgesic use in the placebo group than                      In the second randomized trial on
the aromatherapy group. Wound healing                     aromatherapy for postpartum sleep,
was also better in the aromatherapy                       Mirghafourvand et al32 randomly as-
group—on day 7 the aromatherapy group                     signed 96 women in the first week post-
had a significantly better (lower) overall                partum to ingest placebo or essential oils.
Redness, Edema, Ecchymosis, Discharge,                    Women were excluded if they had a
and Approximation (REEDA) score                           diagnosis of depression during pregnancy.
(a measurement of perineal healing) com-                  The aromatherapy intervention consisted
pared with the placebo-treated group                      of drinking a glass of water with 10 drops
(2.03 vs. 3.93, P = 0.013), as well as better             essential orange peel oil (C. sinensis L.), 3

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Aromatherapy in Obstetrics                11

times daily for 8 weeks. The placebo was               The researchers measured stress, anxiety,
similar in appearance and odor to the                  and depressive symptoms (21-item De-
orange peel oil and ingested using the                 pression, Anxiety, and Stress Scale and
same protocol; the study was triple-                   the Edinburgh Postnatal Depression
blinded. Sleep quality was measured with               Scale) at 2 weeks, 1 month, and 3 months
the Pittsburgh Sleep Quality Index. At 8               postpartum. The authors did not report
weeks, after controlling for the baseline              baseline levels of depression and anxiety.
sleep score, sleep quality was significantly           Average scores of stress, depression, and
improved in the aromatherapy group                     anxiety were significantly lower in the
(MD = 5.0, 95% confidence interval: 3.9-               aromatherapy group at all 3 follow-up
6.1, P = 0.001). In terms of side effects,             time points. For example, at 3 months,
study participants reported similar levels             the aromatherapy group had significantly
of dizziness in both groups. The control               lower stress levels (3.81 ± 3.48 vs.
group had reports of heart palpitations                7.27 ± 5.11, P = 0.001), anxiety levels
(9.3%) and nausea (4.2%), while the ar-                (1.23 ± 1.94 vs. 4.13 ± 3.43, P = 0.001),
omatherapy group reported increased uri-               and depressive symptoms (2.13 ± 2.44 vs.
nation (10.4%).                                        5.07 ± 3.97, P = 0.001). Furthermore, the
                                                       distribution of depression was signifi-
Symptoms of Depression and Anxiety                     cantly lower in the aromatherapy group
We found 2 systematic reviews evaluating               at 2 weeks (18.6% vs. 35.7%, P = 0.023),
the effects of aromatherapy on postpar-                1 month (2.9% vs. 30%, P = 0.001), and
tum mental health (Rezaie-Keikhaie and                 3 months (4.3% vs. 24.3%, P = 0.001).
colleagues; Tsai and colleagues), with the             Although the results are significant, this
Tsai and colleagues’ review being more                 study is limited by its lack of a placebo
comprehensive and of higher quality.21,22              treatment.
Tsai and colleagues assessed the quality of               Although 3 of the trials in the Tsai and
studies using the modified Jadad scale, in             colleagues’ review show promising results for
which studies are scored between 0 (the                aromatherapy’s effects on postpartum psy-
lowest quality) and 8 (the highest quality);           chological symptoms, 2 trials—testing a
the review authors considered all studies              lavender-infused bath and citrus-imbibed
scored ≥ 4 to be “high” quality. Tsai and              drink—did not find any significant effects
colleagues found mixed results on the                  from aromatherapy on depression and anxi-
effects of aromatherapy on psychological               ety. In a high-quality study (modified Jadad
health postpartum. Three studies of inha-              score of 6), Mirghafourvand and colleagues
lation aromatherapy of either lavender or              carried out a double-blinded, RCT testing
C. aurantium found improved symptoms                   the effects of ingesting orange peel essential
of depression or anxiety levels. The largest           oil (C. sinensis L.) in 96 postpartum women
of these trials (n = 140) was published by             without a history of depression. The trial
Kianpour et al33 (modified Jadad score of              protocol was previously described in the sleep
4). Immediately after giving birth, partic-            section of this paper; the sleep results were
ipants in Iran were randomly assigned                  published separately from the depression
to aromatherapy or routine care after                  results. In contrast to the findings from
discharge (no placebo was used). The                   Kianpour and colleagues, Mirghafourvand
researchers excluded anyone with preg-                 and colleagues did not find any differences
nancy complications. The aromatherapy                  between aromatherapy and placebo groups
group was instructed to put 3 drops of                 in depression (as measured by the Edinburgh
lavender oil on their palms, rub them                  Postanal Depression Scale) or state/trait
together, and inhale. This process was                 anxiety (as measured by the State-Trait
carried out 3 times daily for 4 weeks.                 Anxiety Inventory questionnaire) at 8 weeks

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12       Bertone and Dekker

postpartum. Depressive symptoms improved                  postpartum periods. Although 2 trials
in both groups over time (aromatherapy:                   have found that peppermint oil did not
8 ± 3.6 to 6.7 ± 4.8; placebo: 8.1 ± 3.3 to               reduce prenatal nausea and vomiting, 1
6.7 ± 4.9; P = 0.005) but there was no differ-            randomized trial found promising results
ence between groups (P = 0.925). State and                for lemon oil inhalation.23 Another
trait anxiety scores were similar at baseline             randomized trial found that prenatal
and 8 weeks postpartum in both groups.                    massage with lavender essential oil had
                                                          immediate effects on stress relief, as well
                                                          as a beneficial effect on long-term im-
Discussion                                                mune function.10
The physiological effects of aromatherapy                     Aromatherapy (administered either via
are best understood from a holistic point of              body massage or inhalation) appears bene-
view, in that the whole “package” should be               ficial at reducing pain throughout the entire
considered instead of just its parts. To start            first stage of labor and reducing anxiety
with, each essential oil contains many                    during the latent phase of first-stage labor.13
chemical constituents in various proportions              The intervention has unknown effects on
to form its chemical profile. The oil’s                   anxiety in second-stage and third-stage la-
chemical profile is affected by climate,                  bor. In addition, aromatherapy may be
altitude, seasons, and the plant’s growing                beneficial in reducing the duration of the
conditions; deterioration occurs over time                active phase of first-stage labor and the
with exposure to air (oxidation), heat, and               duration of the third stage compared with
ultraviolet light.1 Next, the method, dose,               control.14 Aromatherapy during labor has
and frequency of administration influence                 not demonstrated an effect on the risk of
the effects of aromatherapy. For example,                 intrapartum cesarean or newborn Apgar
hot water and steam from a bath or foot-                  scores.13,14
bath encourages greater absorption of es-                     Aromatherapy (administered via drops
sential oils via the skin and via the                     on cotton or with a mask) plus analgesia
respiratory tract; likewise, massage enhan-               may slightly decrease pain at 12 and
ces absorption due to increased blood flow                24 hours after a cesarean compared with
from manipulating the skin and via the                    placebo plus analgesia.18 Lavender oil
inhalation of vaporized molecules.1 Meth-                 added to sitz baths may benefit wound
ods of administration that combine CAM                    healing and pain after an episiotomy.21,23
therapies may have a beneficial synergistic               Aromatherapy has unknown effects on
effect, such as aromatherapy with hydro-                  perineal tears; therefore, more research is
therapy, or aromatherapy with massage                     needed to see if aromatherapy would be
therapy. Importantly, the mother’s involve-               beneficial when caring for tears unrelated
ment in decision-making (autonomy), any                   to episiotomy use. However, given the
additional support from care providers, and               benefits seen in postepisiotomy trials, it’s
the quality of the care provider-patient                  possible that it may be beneficial with
relationship may also influence the thera-                other types of perineal trauma. In terms
peutic effects of aromatherapy. Finally,                  of postpartum sleep, lavender inhalation
individual recipients may respond differ-                 seemed to confer benefits on sleep
ently to aromatherapy because of personal                 quality.31 These results are consistent with
characteristics affecting bioavailability (ie,            research showing a positive effect of
age, metabolism, skin integrity) and because              lavender aromatherapy on sleep quality
of their unique psychology.                               in other populations.34,35
   Overall, we found evidence that aro-                       A growing number of researchers have
matherapy can positively impact out-                      also evaluated the effects of aromatherapy
comes in the prenatal, intrapartum, and                   on symptoms of depression and anxiety

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Aromatherapy in Obstetrics                13

after giving birth. So far, inhalation of              use of pain medication, this could lead to
lavender and C. aurantium have been found              a lower cost of care. The authors reported
to be helpful in randomized trials, while              that a year’s supply of aromatherapy and
lavender-infused baths and ingestion of                massage oils cost about $500 at a center
citrus oils have not been shown to be                  with 3000 births per year. For a compre-
effective.21 More high-quality research on             hensive discussion of aromatherapy in
aromatherapy and postpartum mental                     maternity care and how to implement
health is needed, particularly with placebo-           aromatherapy in practice, see the study by
control, blinding, and transparent reporting           Tiran.1
of randomization techniques.
   Missing from the research are the                   POTENTIAL RISKS AND SAFETY
voices of birthing people, as we were not              PRECAUTIONS
able to find any qualitative studies on the            Essential oils are highly concentrated
use of aromatherapy in the peripartum                  chemicals that work in the same way as
period. However, there are several older               pharmacologic drugs once absorbed in
studies that include some questions re-                the body. In a professional handbook
lated to satisfaction and reasons for using            authored by Tiran, the author writes that
aromatherapy. In 2000, a British prospec-              there is a misconception that aromather-
tive study by Burns et al36 found that                 apy simply involves the use of fragrant
> 50% of mothers (n = 8058) rated aro-                 oils.1 Instead, essential oils are very
matherapy as helpful for coping with                   powerful and can be potentially hazard-
labor. In this study, 10 different essential           ous if used inappropriately. While most
oils were used, based on consultation with             oils are suitable for use in clinical aroma-
an aromatherapist: rose (Rosa centifolia),             therapy, including during pregnancy,
jasmine (Jasminum grandiflorum), chamo-                some are contraindicated.1,38,39 For ex-
mile (C. nobile), eucalyptus (Eucalyptus               ample, oils from sweet birch (Betula lenta)
globulus), lemon (Citrus limonum), man-                and wintergreen (Gaultheria procumbens)
darin (C. reticulata), clary sage (S. sclar-           can cause salicylate toxicity similar to
ea), frankincense (B. carteri), lavender               overdose from aspirin. Oils that contain
(L. angustifolia) and peppermint (Mentha               high levels of phenols, such as cinnamon
piperita). Of these, rose oil was rated most           bark (Cinnamomum camphora) and clove
highly by mothers for coping with labor                bud, leaf, or stem (Syzygium aromati-
(71%), followed by lavender (50%), and                 cum), are also generally contraindicated
frankincense (44%). Peppermint oil was                 because of high potential for skin irrita-
rated as highly effective for nausea and/or            tion.
vomiting during labor. In another study,                  All essential oils are toxic at high doses.
researchers from the UK found in a                     The clinical guidelines by Tiran recom-
retrospective analysis that women who                  mend dosages of 1% to 1.5% in pregnancy
used an aromatherapy and massage intra-                (1 drop of essential oil to 5 mL carrier oil,
partum service (AMIS) had significantly                with grape seed being one of the most
lower rates of epidural anesthesia, spinal             popular and inexpensive carrier oils), and
anesthesia, and general anesthesia com-                2% during labor and the postpartum
pared with those who did not use AMIS                  period (2 drops of essential oil to 5 mL
after adjustment for parity.37 The most                carrier oil).1 No > 3 essential oils should
commonly reported reasons for using                    be used in a blend so that problematic oils
AMIS were for relaxation/calming                       can be quickly identified. For hydrother-
(29.9%, n = 645) and pain relief (29.6%,               apy, 4 to 6 drops of essential oil in 2 mL of
n = 638). The researchers proposed that if             carrier oil can be added while running a
aromatherapy during labor decreases the                bath (not in the presence of ruptured

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14       Bertone and Dekker

membranes), while 3 to 4 drops can be                     reactions, clinicians are advised to take a
mixed into a footbath. It is thought that                 medical history about the client’s skin
vaporizers should be used for no > 10 to                  condition and any sensitivities or
15 minutes at a time (as overuse may                      allergies.1 Taking care to dilute the oil
desensitize the recipient to the effects of               appropriately is for the client’s benefit as
the essential oils and potentially lead to                well as the care provider, who may also be
nausea, headaches, and drowsiness); va-                   at risk of dermatitis from frequent expo-
porizers should only be used after careful                sure. Photosensitivity is a potential side
consideration of all individuals who                      effect of essential oils, especially with
might be exposed to the vapors. Admin-                    citrus oils (including C. lemon and C.
istering essential oils via the mucus mem-                aurantium). Although citrus oils are
branes (oral, vaginal, or rectal) during                  among the safest oils for use in pregnancy,
pregnancy is not recommended. It is                       it is best to avoid strong sun exposure for
important to purchase oils from a repu-                   a few hours after dermal application.1
table supplier to avoid adulteration with                     It is outside the scope of this review to
lower quality substances.                                 provide complete profiles on essential
   There is a lack of evidence on the safety of           oils; more detailed information can be
specific essential oils in the peripartum peri-           found in professional handbooks.1 Aro-
od. However, no adverse events were re-                   matherapy may not be appropriate for
ported in any of the included studies2,9,12,15            people with certain medical or pregnancy-
and there was no evidence of an effect on                 related complications, or with particular
Apgar scores13 or the rate of cesareans.2,14 In           medications. For example, aromatherapy
2000, Burns et al36 published a large pro-                is considered contraindicated with epi-
spective study that followed 8058 mothers                 lepsy, major respiratory disorders, major
who gave informed consent to receive aro-                 cardiac disease, liver/gallbladder/kidney
matherapy during labor at a British teaching              disorders, and insulin-dependent diabetes.
hospital between 1990 and 1998. Overall,                  Note that caution is needed when using
only 1% of mothers reported undesired                     lavender with hypotension or with epi-
effects from aromatherapy. The reports were               dural anesthesia as it may lower blood
typical of symptoms commonly reported                     pressure. Rose oil should be avoided until
during labor, so it is impossible to know                 the late third trimester because of a
whether the symptoms were caused by the                   possible mild emmenagoguic effect (herb-
aromatherapy. Also, the symptoms in this                  al emmenagogues were traditionally used
study might have been related to pharmaco-                as abortifacients). Clary sage, also, should
logic analgesia—when the study began in                   be avoided until term due to a possible
1990, 13% of mothers who used aromather-                  effect on uterine action.1
apy also used pethidine; however, by 1997
this figure was
Aromatherapy in Obstetrics                15

those of combination interventions such                authors called the evidence “low-certainty”
as massage therapy and hydrotherapy.                   due to the risk of bias. The evidence on
Second, the majority of trials on aroma-               using aromatherapy to treat postcesarean
therapy during the peripartum period                   nausea is limited to 1 small RCT. Finally,
were conducted in the Middle East (most                there is limited data on which specific
notably Iran), which may limit general-                essential oils are best for different clinical
izability to other populations with differ-            indications; lavender oil was featured in
ent perinatal practices. Third, another                many studies, however, this may be more
limitation is that very few studies have               a sign of its popularity rather than superior
been conducted for several of the clinical             clinical effectiveness.1 Future trials should
indications. For example, the supportive               be conducted in diverse settings with a large
evidence on aromatherapy to treat nausea               enough sample size to detect effects on
and vomiting during pregnancy comes                    clinical outcomes. Studies with random
from a single trial on lemon oil. Similarly,           assignment to several different essential oils
we identified only one trial on lavender               and methods of administration may be
aromatherapy to reduce stress and en-                  especially useful.
hance immune function during preg-                        However, despite these research limi-
nancy. Stronger evidence from future                   tations, the essential oils covered in the
RCTs and meta-analyses will be neces-                  reviewed studies were not shown to cause
sary to build on current findings.                     harm during the perinatal period. The use
   Furthermore, although researchers have              of aromatherapy appears to be accepted
attempted double-blinded trials of aroma-              by clients as helpful for coping with
therapy (ie, with normal saline placebo,               nausea/vomiting and stress during preg-
almond oil placebo), blinding may have been            nancy, labor pain, and anxiety, and post-
inadequate given the nature of the interven-           cesarean symptoms, perineal trauma,
tion. However, determining the impact of the           sleep quality, and depression/anxiety.
placebo effect on the effectiveness of aroma-
therapy may be less important with this
treatment, as aromatherapy intervention is             Conclusions
low cost and appears to have few adverse               In the past 10 years, a growing body of
effects,40 although few studies have examined          research has demonstrated the potential
specific safety outcomes with aromatherapy             benefits of aromatherapy during the peri-
during the peripartum period.                          natal period. Obstetric providers should
   The authors of the Liao and colleagues’             be aware that pregnant clients in their
meta-analysis described the general quality            care might be using this modality during
of studies on aromatherapy for labor pain              pregnancy, labor, and postpartum. Sim-
and anxiety as “moderate” because of                   ilarly, there is a need for more open
weaknesses in methodology and the imprac-              communication between pregnant people
tical of blinding. None of the 9 included              and care providers about aromatherapy
trials in the Liao et al13 meta-analysis were          use, as well as a need for provider training
double-blinded. There was also high hetero-            on aromatherapy (and other CAM mo-
geneity across the trials, and this limitation         dalities). To attain a more holistic set of
requires further exploration in subgroup               skills and knowledge, obstetric care pro-
analyses. Therefore, more clinical trials with         viders should understand the reasons why
high methodological quality are needed                 clients may seek aromatherapy during the
before strong recommendations regarding                peripartum period, contraindications and
efficacy can be made to expectant parents              precautions regarding aromatherapy, and
and clinicians. As far as using aromatherapy           the evidence on aromatherapy for a vari-
to decrease postcesarean pain, the Cochrane            ety of indications.

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