NRG Renew - Colorado Chiropractic Association
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FUNCTIONAL HEALTH SERIES
NRG Renew
Supportive Functions: Energy, performance, stress and aging, along
with nerve, immune and brain function; general balancing of
homeostatic functions.
NRG Renew is a unique combination of adaptogenic herbs that support energy processes
(for instance the energy-producing mitochondria). Energy is needed for all biochemical
reactions that take place, whether it is in the central nervous system, the immune system,
endocrine system, or simply
our ability to perform daily
activities, age gracefully, or
get through a workout. These
herbs “adapt”, or help bring
organ systems into balance,
from either a high or low
status quo. Balancing systems
that are hindered by non-
homeostatic mechanisms is
sometimes what is needed to
allow energy processes to
flow. In addition to balancing
out of sync systems, adaptogens also possess individual characteristics (because of their
unique components) that affect these various pathways in a positive manner.
The Synergy of it all: Three of the adaptogens in the NRG formula (eleuthero,
schisandra, rhodiola) along with individual components (eleutheroside E, schizandrin
B, salidroside, triandrin, and tyrosol) are key players in regulating NF-kB-mediated
responses. NF-kB is noted for disrupting cellular environments, while the adaptogens
are noted for supporting a homeostatic, calm cellular environment (Front Neurosci. 2013 Feb
20;7:16 Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of
Other common targets of these adaptogens were
Isolated Neuroglial Cells. Panossian A et al).
observed by the researchers (Panossian et al. 2013) to include genes encoding for: an
estrogen receptor, cholesterol ester transfer protein, heat shock protein, serpin peptidase
inhibitor (neuroserpin), and the 5-HT3 receptor of serotonin. The findings were
believed to be associated with the observed beneficial support effects of the adaptogens
in behavioral, mental, and age related scenarios.
NRG Renew Synergy (cont’d)
In the Panossian study, combining two or more active substances in one mixture affected gene
profiles in a way that that none of the individual substances affected the profiles - demonstrating
the epigenetic and synergistic interactions of the adaptogens (Panossian et al. 2013) Epigenetic
means “above genetics”, describing environmental influences on gene activity.
Rhodiola Rosea (root) contains several compounds, including epicatechin gallate (ECG), 1,2,3,4,6-O-
pentagalloylglucose (PGG), rhodionin, herbacetin and rhodiosin, which all have high biological
activity.
One of the things that these compounds are responsible for is
having an inhibitory effect on acetylcholinesterase, which is the
enzyme that breaks down the anti-inflammatory
neurotransmitter, acetylcholine (Ach) (Int J Biol Macromol. 2017
Nov;104(Pt A):527-532. Molecular interaction studies of acetylcholinesterase with potential
acetylcholinesterase inhibitors from the root of Rhodiola. Li FJ et al.)
When the enzyme is inhibited, it leaves more of the Ach
circulating, and that is a good thing.
Rhodiola rosea “has been used extensively in traditional
medicine” to support physical and mental performance,
heart function, mood, cognitive function, osteoblast activity
(bones), immune system and guard against stress (J Med
Food. 2016 Mar;19(3):318-23. Extension of Drosophila Lifespan by Rhodiola rosea.
Schriner SE et al.; Phytomedicine. 2016 Jun 15;23(7):763-9. …Rhodiola rosea, a natural
selective estrogen receptor modulator. Gerbarg PL & Brown RP).
Eleuthero is another herb that has an outstanding
reputation for stress support. It is believed that both
Eleuthero and panax ginseng affect stress hormone
receptors which function to redistribute the body’s
energy reserves, and it may even be this characteristic
that betows the reputation on these herbs for such
excellent energy support (Med Hypotheses. 2001 May;56(5):567-72.
Panax ginseng and Eleutherococcus senticosus may exaggerate an already
existing biphasic response to stress via inhibition of enzymes which limit the
binding of stress hormones to their receptors. Gaffney BT et al.)
Rhodiola and Healthy Aging:
Recent evidence has strongly supported the fact that
the rate of aging is controlled, at least to some extent,
by evolutionarily conserved nutrient sensing path-
ways. Some nutritional agents, such as rhodiola,
target these nutrient sensing pathways and are believed
to be able to reprogram the energy metabolism of
cells, and confer multiple systematic metabolism
benefits (Curr Pharmacol Rep. 2015 Dec 1;1(6):420-433. …Can …Aging
Agent Kill Two Birds with One Blow? Yokoyama NN et al.)
Rholiola and Metabolic Lipid Stability/Blood Sugar: Rhodiola may possess the ability to affect
alpha-glycosidase activity, and support blood sugar, cholesterol and triglyceride pathways. In fact
clinical trials have demonstrated a
homeostatic blood sugar effect (Zhongguo Zhong
Yao Za Zhi. 2013 May;38(9):1411-5. Investigation of a
compound, compatibility of Rhodiola … on metabolic syndrome…
Tian JY et al.; J Ethnopharmacol. 2012 Aug 1;142(3):782-8.
Rhodiola crenulata root ameliorates derangements of glucose and
Wang et al. also point
lipid metabolism...Wang, J et al.)
out that rhodiola is traditionally used for
tonics and stimulants because of its effect
on energy metabolism. Rhodiola favorably
changes something called the “endogenous
antioxidant enzyme response” (AER)
and energy pathways during adipogenesis (fat
production). This favorable change raises superoxide dismutase activity, which reduces reactive free
radicals, and by this mechanism supports lipid and weight balance (Phytother Res. 2011 Jan;25(1):106-15. Rhodiola-
induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway. H et al.)
Rhodiola and Exercise Performance: In a double blinded, crossover study in 10 males, ingestion of
rhodiola rosea “favorably influenced RPE (rated perceived exertion) and exercise effect without
changes in energy expenditure or substrate utilization during 30-minute submaximal cycling
performance” (J Sports Med (Hindawi Publ Corp) 2014;2014:563043. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate,
Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. Duncan MJ & Clarke ND.)
Rhodiola and Exercise Performance (cont’d)
A seven-hour continuous physical loading test (bicycle ergometry) was used to assess effects of rhodiola
on the human cardiorespiratory system. Compared with the control, the preparation facilitated activation
of the energy-supplying mechanisms during physical work. In
addition, it supported the cardiovascular and respiration systems and
helped with fatigue (Aviakosm Ekolog Med. 2009 Nov-Dec;43(6):52-6. Effect of
cryopowder Rhodiola rosae L. on cardiorespiratory parameters and physical performance of humans.
Evdokimov VG.)
Rhodiola has been shown to be helpful in studies involving exhaustive
swimming, and it was able to affect glycogen levels to support optimal
performance (Am J Chin Med. 2009;37(3):557-72. Chronic Rhodiola rosea extract
supplementation enforces exhaustive swimming tolerance. Lee FT et al.) Rhodiola may even
help shift anaerobic metabolism to aerobic metabolism (Food Chem
Toxicol. 2009 Jun;47(6):1239-45. Mechanism of action of Rhodiola imbricata Edgew during exposure
to cold, hypoxia and restraint... Gupta V et al.)
Gotu kola (Centella asiatica) has been used for thousands of years in India, Indonesia and China,
where it has been called "the fountain of life" and used to maintain immune, nervous system and brain
function. Gotu kola has been used as well “in scientifically oriented medicine... The active compounds
include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids... The
mechanism of action involves promoting fibroblast
proliferation”, along with supporting the synthesis of
collagen, intracellular fibronectin content, and the tensile
strength of newly formed skin, demonstrating its role in
the healthy aging process of skin (Postepy Dermatol Alergol. 2013
Feb;30(1):46-9. Centella asiatica in cosmetology. Bylka W et al.)
Gotu kola has also been used for respiratory, liver and
circulation support, especially when veins start to lose
their elasticity. The efficacy for maintaining the
homeostasis of venous circulation was reported by
researchers who noted that gotu kola presented an
“option for patients prone to microcirculation
disturbances during long flights” (Angiology. 2001 Oct;52 Suppl
2:S33-7. Flight microangiopathy in medium- to long-distance flights: prevention
of edema and microcirculation alterations with total triterpenic fraction
of Centella asiatica. Cesarone MR et al.)
Gotu kola (Centella asiatica) (cont’d)
The mechanism for providing circulation support is believed to be the effect that gotu kola
triperpenoids (and other active components) have on the metabolism in the connective tissue of the
vascular wall (Int J Clin Pharmacol Res. 1990;10(4):229-33. Effects of Centella asiatica extract on mucopolysaccharide metabolism in
subjects with varicose veins. Arpaia MR et al.) The circulation and antioxidant activity of gotu kola active
components, in addition to its collagen support qualities contribute to its reputation for use in support
of the wound healing process (Postepy Dermatol Alergol. 2013 Feb;30(1):46-9. Centella asiatica in cosmetology. Bylka W et al.;
Biswas TK, Mukherjee B. Plant medicines of Indian origin for wound healing activity: a review. Int J Low Extrem Wounds. 2003;2(1):25-39.)
These components are also credited with helping to maintain a calm environment under stress (Jana U, et
al. A clinical study … with Centella asiatica. Nepal Med Coll J. 2010 Mar;12(1):8-11; Bradwejn J, et al. A double-blind, placebo-controlled study on
the effects of Gotu Kola on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000;20(6):680-684.)
Korean Ginseng (Panax Ginseng) is well-known as one of
the best and most popular adaptogenic herbs. It has many
active constituents that have a reputation for supportive use
in cardiovascular health, arterial blood vessel elasticity and
brain health, bone health, blood sugar homeostasis, and cell-
cycle regulation, in addition to being widely used as support
in the recovery process after brain and lung injury (J
Ethnopharmacol. 2019 Feb 22;236:443-465. Analytical methods and biological
activities of Panax notoginseng saponins: Recent trends. Xu C et al.)
Additionally, ginsengs are noted for optimizing endurance
performance (J Int Soc Sports Nutr. 2018 Mar 15;15:14. Herbal medicine for
sports: a review. Sellami M. et al.)
Eleuthero (Eleutherococcus senticosus with standardized eleutherosides) sometimes called
Siberian ginseng, also has a reputation as an adaptogenic
herb that provides excellent support for many systems
including sports activity. For instance, the effect that
eleuthero has on the fatty acid β-oxidation energy
changes in skeletal muscle are believed to be helpful in
the recovery process from exercise fatigue (Nat Prod J. 2016
Mar;6(1):49-55. Effects of Eleutherococcus senticosus Cortex on Recovery.
Sumiyoshi M & Kimura Y.)
Eleuthero (Eleutherococcus senticosus) (cont’d)
One of the proposed mechanisms for successful brain and cognitive support of eleuthero comes from
the influence eleuthero has on acetylcholine, the neurotransmitter associated with the calm,
parasympathetic nervous system, as opposed to epinephrine and the sympathetic nervous
(Neuroreport. 2019 Feb 6;30(3):188-194. Eleutheroside E attenuates isoflurane-induced… dysfunction by regulating the α7-nAChR-NMDAR
Specific attention has focused on Eleutheroside E, one of the very bioactive
pathway. Lu X & Xiao-Qing C.)
components of eleuthero.
Adaptogens are natural compounds or plant extracts that increase adaptability and
survival of organisms under stress. Adaptogens stimulate cellular and organismal
defense systems by activating intracellular and extracellular signaling pathways and
expression of stress-activated proteins and neuropeptides.
The effects that adaptogens have on mediators
of adaptive stress response and longevity
signaling pathways are balancing, adaptogenic
\ and homeostatic.
Schisandra (fruit) has been utilized for a wide variety of support, most notably for that of the liver,
and every function of the liver. As an effective adaptogen, schisandra supports the homeostasis of all
liver irregularities (Molecules. 2017 Sep 28;22(10). pii: E1617. A Network Pharmacology-Based Study on the Hepatoprotective Effect of
Fructus Schisandrae. Hong M et al.)
Schisandra polysaccharides have high levels of medicinal sugars, such as mannose, galactose, and
arabinose that exhibit many health benefits. The extremely high antioxidant power is instrumental in
the health benefits as well. Benefits include support of the immune system, nervous system,
cardiovascular system, mitochondria, cognition, inflammation, cartilage health, insulin secretion, lipid
balance, aging, physical endurance, etc. etc. (Int J Biol Macromol. 2019 Mar 20;131:744-751. Chen X et al.;Molecules. 2019
Mar 20;24(6). pii: E1090. Shen Z et al.; J Ethnopharmacol. 2019 Mar 14;237:28-38. Qi Y et al.; J Ethnopharmacol. 2019 Mar 4. pii: S0378-
8741(18)33839-X. Xu M et al.; Am J Transl Res. 2019 Jan 15;11(1):199-209. Zhou F et al.; Front Pharmacol. 2019 Jan 29;10:41. Tu, C et al.;
Nutrients. 2019 Feb 4;11(2). pii: E333. Nowak A et al.)
Schisandra is also helpful in gastric cell regulation (Pharm Biol. 2015 Feb;53(2):212-9. Kim HS et al.), and has been
lauded by researchers for excellent support of neuronal cells (Fitoterapia. 2019 Feb 20;134:108-112. Aromatic
monoterpenoid glycosides from Schisandrachinensis and their neuro… activities. Liu Y et al.)
Ashwaganda (root) Ashwaganda (root) is another multi-talented herb that possesses many health properties. Researchers have noted that it is “a well-known adaptogen for reducing stress in humans”, and stress is notorious for creating multiple imbalances. A double-blind, randomized, placebo-controlled trial with 52 subjects was conducted on ashwagandha and stress-affected individuals. Primary efficacy measures were the Perceived Stress Scale and the Food Cravings Questionnaire. Secondary efficacy measures were the Oxford Happiness Questionnaire, the Three-Factor Eating Questionnaire, serum cortisol, body weight, and body mass index. Each subject was assessed at the start and at four and eight weeks. The ashwagandha group was supported in all primary and secondary measures (J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106. … Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. Choudhary D. et al.) One of the states of imbalance caused by stress can be thyroid activity. A prospective, randomized, double-blind, placebo-controlled study was conducted on fifty subjects for 8-weeks. Efficacy variables measured were serum thyroid values. The study concluded that the group receiving ashwagandha was more fully supported for homeostasis of thyroid function (J Altern Complement Med. 2018 Mar;24(3):243-248. Efficacy and Safety of Ashwagandha Root Extract … Patients: A Double-Blind, Randomized Placebo-Controlled Trial. Sharma AK. et al.) Ashwagandha “has long been used in the traditional Ayurvedic system of medicine” for support of brain function and cognition (J Diet Suppl. 2017 Nov 2;14(6):599-612. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract … Choudhary D. et al.) In this prospective, randomized, double-blind, placebo-controlled study that was conducted in 50 adults for eight weeks, ashwagandha was found to be excellent support for brain executive function, attention, and information processing (Choudhary D. et al. ibid) Ashwagandha has a reputation for nerve support, however mechanisms of action have been fairly elusive to scientists. In an attempt to identify mechanisms of action, researchers initiated activity- based protein profiling studies with withanolide A, a constituent of Withania somnifera root (ashwagandha). Molecular probes were designed and synthesized, and led to the discovery of the glucocorticoid receptor as a potential target for mechanism of action. Molecular modeling calculations did predict a binding affinity of withanolide A for the glucocorticoid receptor. The conclusion drawn was that the mechanism of action was not through a direct effect on the glucocorticoid receptor, but that it might be mediated through a closely related pathway. “Further experiments should evaluate a possible role of glucocorticoid receptor modulators and/or related signaling pathways such as ERK, Akt, NF-κB, TRα, or Hsp90 as potential targets” in withanolide A-mediated effects on nerve support (Bioorg Med Chem. 2019 Mar 13. pii: S0968-0896(19)30232-9. Profiling withanolide A for therapeutic targets … Crane EA. et al.)
NRG RENEW™
NRG Renew is a formula of adaptogenic herbs with the diverse ability to help organisms “adapt”
or maintain homeostasis in various systems (immune, CNS,
endocrine) including the energy-producing mitochondria, and offers
exceptional support for sports activities.
Each Tablet Contains: Proprietary blend 800 mg* of:
Rhodiola Rosea (root), Eleuthero (root), Panax Ginseng
(root), Schisandra Chinensis (fruit), Ashwagandha (root)
Extract, Gotu Kola (herb) Extract.
90 – Tablets Per Bottle 2848*** - Product Order Number
Contraindications: Avoid use during pregnancy and lactation;
Gotu kola may induce menstruation.
***No Frees with this product
Compliments of
NUTRI-WEST
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1-800-443-3333; FAX 1-307-358-9208
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www.NutriWest.com
The above statements have not been evaluated by the FDA. The nutritional information, suggestions, and research provided are not
intended to diagnose, treat, cure, or prevent disease and should not be used as a substitute for sound medical advice. Please see your
health care professional in all matters pertaining to your physical health.
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