2021 Graduate Programs - THE MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
THE MAX PLANCK FLORIDA
INSTITUTE FOR NEUROSCIENCE
2021
Graduate
Programs
Contact imprs@mpfi.org for any application
inquiries or visit mpfi.org/graduate-programs/
OUR SCIENCE
Research Groups at the
Max Planck Florida Institute for Neuroscience More information at mpfi.org
Disorders of neural circuit function Neuroenergetics
PI: MCLEAN BOLTON PI: VIDHYA RANGARAJU
Research in the Bolton Lab employs electrophysiological The Rangaraju Lab is interested in how neurons with their
and imaging techniques to study alterations in circuit structure unsurpassed morphological complexity manage their energy
and function in mouse models of neurological and psychiatric landscapes. We focus on the proteins that comprise and regulate
disorders. mitochondria and the other energy supplies.
Neuronal control of locomotion Integrative neural circuits and behavior
PI: SALIL BIDAYE PI: SARAH STERN
The Bidaye lab studies the neural circuit logic of locomotor
The Stern Lab studies how learning mechanisms and diverse
decisions using the fruit-fly (Drosophila melanogaster) as a model
environmental stimuli alter innate brain circuits to drive both
system and a combination of techniques including behavioral
adaptive and maladaptive behavioral outcomes.
assays, optogenetics, multiphoton imaging, and electrophysiology.
Functional architecture and development of cerebral cortex Neuronal mechanisms of episodic memory
PI: DAVID FITZPATRICK PI: YINGXUE WANG
The Wang Lab integrates electrophysiological, imaging, and
Research in the Fitzpatrick Lab utilizes state-of-the-art in
optogenetic approaches with computational modeling to reveal
vivo imaging techniques to probe the functional synaptic
the circuit underpinnings of the sequential neuronal activity
architecture of circuits in primary visual cortex.
underlying our ability to remember, think, and plan.
Neural dynamics and cognitive functions Neuronal signal transduction
PI: HIDEHIKO INAGAKI PI: RYOHEI YASUDA
The main goal of Inagaki lab is to develop a cellular and The Yasuda Lab is interested in the operation principles of
network-level understanding of how internal states, such as signaling networks in dendritic spines. They have been developing
internal drives and urgency, modify dynamics in the frontal techniques to image activity of various proteins in single dendritic
cortex to influence cognitive functions. spines using 2pFLIM in combination with new biosensors.
“When I was considering graduate schools, the
collaborative space that was cultivated was a
major factor drawing me to MPFI because I knew
how much more I could learn because of it. Also
GRADUATE PROGRAM my supervisor had provided an excellent training
IMPRS
environment where I could work with experienced
scientists using leading-edge techniques to
address important questions”
for Synapses and Circuits Daniel Wilson, Ph.D., IMPRS Program Alumnus Publication-inspired artwork featured on
the cover of Nature Neuroscience
Currently Postdoctoral Fellow at Harvard Medical School
International Max Planck Research School
Scholl, B., Wilson, D.E., Jaepel, J., and Fitzpatrick, D. (2019). Functional Logic of Layer 2/3 Inhibitory Connectivity
in the Ferret Visual Cortex. Neuron 104, 451-457.e3.
Wilson, D.E.*, Scholl, B.*, and Fitzpatrick, D. (2018). Differential tuning of excitation and inhibition shapes direc-
tion selectivity in ferret visual cortex. Nature 560, 97–101.
Wilson, D.E., Smith, G.B., Jacob, A.L., Walker, T., Dimidschstein, J., Fishell, G., and Fitzpatrick, D. (2017). GABAer-
gic Neurons in Ferret Visual Cortex Participate in Functionally Specific Networks. Neuron 93, 1058–1065.
Scholl, B., Wilson, D.E., and Fitzpatrick, D. (2017). Local Order within Global Disorder: Synaptic Architecture of
Visual Space. Neuron 96, 1127-1138.
Wilson, D.E., Whitney, D.E., Scholl, B., and Fitzpatrick, D. (2016). Orientation selectivity and the functional clus-
tering of synaptic inputs in primary visual cortex. Nat Neurosci . 19, 1003-1009.
The International Max Planck Research School (IMPRS) for Synapses and Circuits
provides comprehensive Ph.D. training coupled with cutting-edge technology,
resources, and collaborations with the world-renowned Max Planck Society. The “ I am very thankful to my supervisor for
IMPRS for Synapses and Circuits is a partnership between MPFI and Florida Atlantic all the support and understanding during
University (FAU) and is the only IMPRS program in the United States. the last few years, so I could focus on
my ambitious project and take care of
• Advanced Scientific Training my family at the same time. I also felt
• International Networking and Conference Opportunities privileged to work at an institute like
• Interdisciplinary World-class Program MPFI that supports and invests in the
• Career Education and Professional Development development of novel methods”.
Ye Sun, Ph.D., IMPRS Program Alumna
APPLICATION PERIOD*: September 01, 2021 - December 01, 2021 Currently Staff Scientist at NHLBI, NIH
* You must complete the Florida Atlantic University Integrative Biology - Neuroscience (IBNS)
Ph.D. program application before December 11, 2021.
Sun, Y., Smirnov, M., Kamasawa, N., Yasuda, R. (2021). Rapid Ultrastructural Changes in the PSD and Surrounding
Membrane after induction of structural LTP in Single Dendritic Spines. Journal of Neuroscience 41, 33, 7003-
7014.
STARTING DATE: August 2022 Sun Y., Thomas C., Mikuni T., Guerrero-Given D., Yasuda R., Kamasawa N. (2020) Correlative Ultrastructural
Analysis of Functionally Modulated Synapses Using Automated Tape-Collecting Ultramicrotome and SEM
Array Tomography. In: Wacker I., Hummel E., Burgold S., Schröder R. (eds) Volume Microscopy.
Neuromethods, vol 155. Humana, New York, NY.
Mikuni, T., Nishiyama, J., Sun, Y., Kamasawa, N., and Yasuda, R. (2016). High-Throughput, High-Resolution
CONTACT Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing. Cell.165, 1803–1817.
mpfi.org/graduate-programs/ or email imprs@mpfi.org Kamasawa, N., Sun, Y., Mikuni, T., Guerrero-Given, D., and Yasuda, R. (2015). Correlative Ultrastructural
Analysis of Functionally Modulated Synapses Using Automatic Tape-Collecting Ultramicrotome - SEM Array
Tomography. Microscopy and Microanalysis 21, 1271–1272.
SELECTED
PUBLICATIONS
authored by MPFI Ph.D. Students
Wilson, D.E.*, Scholl, B.*, and Fitzpatrick, D. (2018). Differential tuning of excitation and inhibition shapes Mikuni, T., Nishiyama, J., Sun, Y., Kamasawa, N., and Yasuda, R. (2016). High-Throughput, High-Resolution
direction selectivity in ferret visual cortex. Nature 560, 97–101. Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing. Cell.165, 1803–1817.
Lee, K-S., Huang, X., Fitzpatrick, D. (2016). Topology of ON and OFF inputs in visual cortex enables an invariant
columnar architecture. Nature. 533, 90–94.
Sun, Y., Smirnov, M., Kamasawa, N., Yasuda, R. (2021). Rapid Ultrastructural Changes in the PSD and Surround-
ing Membrane after induction of structural LTP in Single Dendritic Spines. Journal of Neuroscience 41, 33,
7003-7014.
Wilson, D.E., Whitney, D.E., Scholl, B., and Fitzpatrick, D. (2016). Orientation selectivity and the functional
clustering of synaptic inputs in primary visual cortex. Nat Neurosci . 19, 1003-1009.
Scholl, B., Wilson, D.E., Jaepel, J., and Fitzpatrick, D. (2019). Functional Logic of Layer 2/3 Inhibitory Connectivi-
ty in the Ferret Visual Cortex. Neuron 104, 451-457.e3.
Chang, J.-Y., Nakahata, Y., Hayano, Y., and Yasuda, R. (2019). Mechanisms of Ca²+/calmodulin-depen- Wilson, D.E., Smith, G.B., Jacob, A.L., Walker, T., Dimidschstein, J., Fishell, G., and Fitzpatrick, D. (2017). GABAer-
dent kinase II activation in single dendritic spines. Nature Communications 10, 2784. gic Neurons in Ferret Visual Cortex Participate in Functionally Specific Networks. Neuron 93, 1058–1065.
Scholl, B., Wilson, D.E., and Fitzpatrick, D. (2017). Local Order within Global Disorder: Synaptic Architecture of
Visual Space. Neuron 96, 1127-1138.
Montesinos, M.S., Dong, W., Goff, K., Das, B., Guerrero-Given, D., Schmalzigaug, R., Premont, R.T., Satterfield, R.,
Kamasawa, N., and Young, S.M., Jr. (2015). Presynaptic Deletion of GIT Proteins Results in Increased Synaptic
Lee, D., Creed, M., Jung, K., Stefanelli, T., Wendler, D.J., Oh, W.C., Mignocchi, N.L., Lüscher, C., and Strength at a Mammalian Central Synapse. Neuron 88, 918–925.
Kwon, H.-B. (2017). Temporally precise labeling and control of neuromodulatory circuits in the mam-
malian brain. Nat Meth, 14, 495-503. Chang, J.-Y., Parra-Bueno, P., Laviv, T., Szatmari, E.M., Lee, S.-J.R., and Yasuda, R. (2017). CaMKII Autophosphor-
ylation Is Necessary for Optimal Integration of Ca2+ Signals during LTP Induction, but Not Maintenance. Neuron
94, 800–808.e4.
Lee, K.-S., Vandemark, K., Mezey, D., Shultz, N., and Fitzpatrick, D. (2019). Functional Synaptic Architecture of
Callosal Inputs in Mouse Primary Visual Cortex. Neuron 101, 421-428.E5.
M.A., Rowan*, Bonnan, A.*, Zhang, K.*, Amat, S.B., Kikuchi, C., Taniguchi, H., Augustine, J.G., and Christie, J.M.
(2018). Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.
Neuron, 99, 999-1015.e6.
Tu, X., Yasuda, R., and Colgan, L.A. (2020). Rac1 is a downstream effector of PKCa in structural synaptic
plasticity. Scientific Reports 10, 1–9.
Living in Palm Beach County 47 miles of coastline 78 degrees average year-round temperature 200+ performing arts organizations and museums 31,000 acres of nature preserves 250+ miles of biking and hiking trails
FACILITIES AND CAMPUS:
MPFI’s 100,000-square-foot research facility SCIENTIFIC DIRECTORS:
is built on six acres of land at Florida Atlantic David Fitzpatrick, Ph.D.
University’s (FAU) John D. MacArthur Cam-
pus. This new, LEED Gold state-of-the-art Ryohei Yasuda, Ph.D.
building includes 58,000 square feet of
laboratory space, wet and dry bench re-
SCIENTIFIC
search, instrumentation labs, computational
ADVISORY BOARD:
research, core imaging facilities, microscope
suites and information technology services. Ann Graybiel, Ph.D.
Massachusetts Institute of Technology
On-site Core Facilities:
Michael Hausser, Ph.D.
• Electron Microscopy University College London
• STED Microscopy
• Light Microscopy and Optical Imaging Anthony Movshon, Ph.D.
• Mechanical Workshop New York University
• Molecular Biology Elly Nedivi, Ph.D.
Massachusetts Institute of Technology
JUPITER NEUROSCIENCE Bernardo Sabatini, M.D., Ph.D.
COMMUNITY: Harvard Medical School
The Jupiter Neuroscience Community is a Carla Shatz, Ph.D.
collaboration among neuroscientists from Stanford University
Max Planck Florida Institute for
Gary Westbrook, M.D.
Neuroscience, Florida Atlantic University,
Vollum Institute, OHSU
and the Scripps Research Institute, Florida,
with an extended network of research
excellence in neighboring institutions in
Palm Beach County and throughout Florida.
The collaborative exchange of scientific
10/11
ideas between faculty, postdocs and
students benefits from a broad range of
seminar series, symposia, poster sessions
and networking events.
MP Neuro
BRAIN DISORDERS AND INJURY COGNITION DEVELOPMENT
INTEGRATIVE PHYSIOLOGY AND BEHAVIOR MOTIVATION AND EMOTION
MOTOR SYSTEMS NEURAL EXCITABILITY, SYNAPSES, AND GLIA
SENSORY SYSTEMS TECHNIQUES Max Planck Florida’s
Neurotransmissions
Podcast
The Max Planck Society brings together hundreds of neuroscience researchers, Neuroscience stories from the
lab and life
equipping them with the best tools and resources to explore some of the most
complex issues facing all facets of brain science.
This collective knowledge and expertise promotes creative, interdisciplinary
approaches, allowing Max Planck scientists to make significant advances in
Listen at: neuropodcast.org
the field and develop innovative technologies and techniques to advance
neuroscience research across the globe.
Come see and share the future of neuroscience at
Ma xPl a n c k Ne u rosc ie n c e . o r g
You can also read
