2nd DHU 2020 Autumn school - "From systems biology to new targets and therapeutics"
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2nd DHU 2020 Autumn school “From systems biology to new targets and therapeutics” REPORT DHU 2020 Training event 15 – 16 October, 2015 Nantes, France
IMPRINT Publisher DHU 2020 Project Management Karine.cavailles@univ-nantes.fr Authors Karine Cavailles, Antoine Magnan Pictures Matthieu Pichelin, Nantes, France Date 15 February 2016 Please take note that the content of this document is property of the DHU 2020. If you wish to use some of its written content, make reference to: DHU 2020 Autumn School report: “From systems biology to new targets and therapeutics”, Nantes, France, February 2016.
DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
TABLE OF CONTENTS
1. INTRODUCTION .............................................................................................................. 2
2. PROGRAMME ................................................................................................................ 3
3. EVENT OUTCOME ............................................................................................................ 6
3.1. General informations .............................................................................................................. 6
3.2. Survey statistics ....................................................................................................................... 7
3.2.1. Meeting and Workshop ................................................................................................... 7
3.2.2. Open questionnaire ......................................................................................................... 8
3.3. Sytems biology workshops .................................................................................................... 10
3.4. Oral presentations and poster session .................................................................................. 11
4. LIST OF PARTICIPANTS .................................................................................................... 13
5. CONCLUSION ............................................................................................................... 18
6. ACKNOWLEDGEMENTS ................................................................................................... 19
7. APPENDIX ................................................................................................................... 20
7.1. Survey and questionnaire...................................................................................................... 20
7.2. Open questionnaire ............................................................................................................... 21
7.3. Application procedure for EACCME accreditation ................................................................ 22
1
DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
1. Introduction
The DHU 2020 "Personalized medicine for chronic diseases", provider of the organization of 2015
Autumn school, brings together the strengths of healthcare, teaching and biomedical research from 2
Nantes institutes: l’institut du thorax and l’institut des maladies de l’appareil digestif (IMAD), along
with the humanities and social sciences (HSS) strengths of the "Standards, Diseases and Societies"
topic, CNRS team UMR 6297 "Law and Social Change".
These structures are built around a translational project ranging from premature to elderly subjects
and aimed at promoting the development of personalized medicine for chronic diseases.
The present report on the second training event “From systems biology to new targets and
therapeutics” is part of the training initiatives of DHU 2020 to its graduate and post-graduate
students (Science, Medicine and HSS) and staff, focusing on personalized medicine for chronic
diseases and on the transformations induced by this concept.
According to the participants’ opinions, the meeting was an exciting Systems Medicine symposium,
which presented the highlights of interdisciplinary research, bridging biology, medicine and human
and social sciences with bioinformatics and modeling sciences and putting Nantes as an expert center
position in Systems Medicine.
During this 2 days’ workshop, the invited lectures, oral and poster presentation sessions and
workshop sessions provided state of the art information from the above fields and more particularly
on their integration.
In addition to the training event of DHU 2020, the meeting also represented an excellent opportunity
for social networking of young future scientists and doctors with senior colleagues and to share
knowledge and experience. Importantly, the meeting was supported by the CaSyM initiative
(Coordinating Systems Medicine across Europe) whose program was presented during a session. The
European Accreditation Council for Continuing Medical Education (EACCME) also accredited the
event with 11 European CME credits (ECMEC).
108 participants from 5 countries attended the meeting. 21 of them were researchers, 12 were
medical doctors and 6 Technicians or engineers. 38 of them were Master 2 Degree students (medical
and scientists), 8 were PhD students (science and HSS) and 4 post-doctoral researchers. Thus, the
objective to attract graduate and post-graduate students was reached with 46 % of participants.
It is to note that all participants received a certificate of attendance. The certificate helps students
(Master degree and PhD students) to get their training approved by our local University. No
participant asked for CME credits.
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DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
2. Programme
Thursday 15th October 2015
09 :30 Registration
Prof. A. Magnan (Nantes University, France)
10 :00
Welcome
Prof. C. Pison (Grenoble University Hospital, France)
10 :15
The pioneers of health and well-being: a revolution in progress?
SESSION 1 : From cellular to molecular models
Prof. K. Lund (UNC Chapel Hill, US)
10 :45 Intestinal epithelium health and disease: Stem cells, hormones growth factors nutrition
and bugs
11 :15 Oral communication
11:30 Coffee break and Poster Session
Dr S. Virtue (University of Cambridge, United Kingdom)
12:00 Combining metabolomic and transcriptomic data to identify cellular sources of
metabolites in complex tissues
Prof. P-A. Gourraud (University of California, San Francisco, US)
12:30 Precision Medicine in Chronic Disease Management: The Multiple Sclerosis
BioScreen
01:00 Lunch and Poster Session
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DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
WORKSHOP SESSION 1 :
02:30 WS 01 WS 02 WS 03 WS 04
Dr. G. Meurette C. Dina Prof. P-A. X. Prieur
Gourraud
Nantes University Inserm Inserm
Hospital, Nantes, UMR 1087/CNRS University of UMR 1087/CNRS UMR
France UMR 6291, Nantes, California San 6291, Nantes, France
France Francisco, US
Preclinical
Using omics to
research : the
Making sens out Personalized modelise metabolic
porcine model
of GWAs Medicine starter abnormalities
in a box
04:30 Coffee break and Poster Session
Prof. Damjana Rozman, (Ljubljana University, Slovenia)
04:45
Systems Medicine of multifactorial disorders: A vision of CASyM
C. Bourgain (Paris Descartes University, France)
05:15 Description and Action : On the challenges of using a systemic framework for
therapeutic innovation
05:45 End of sessions
4DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Friday 16th October 2015
WORKSHOP SESSION 2 :
9 :00 WS 01 WS 02 WS 03 WS 04
Dr. G. Meurette C. Dina Prof. P-A. X. Prieur
Gourraud
Nantes University Inserm Inserm
Hospital, Nantes, UMR 1087/CNRS University of UMR 1087/CNRS UMR
France UMR 6291, Nantes, California San 6291, Nantes, France
Preclinical research : France Francisco, US Using omics to modelise
the porcine model metabolic abnormalities
Making sens out of Personalized
GWAs Medicine starter in
a box
11 :00 Coffee break and Poster Session
SESSION 2 : Epidemiology and data analysis
B. Gibaud (LTSI Inserm 1099, Rennes, France)
11:15 Representation and sharing of imaging biomarkers in imaging biobanks for biomedical
and translational research
11 :45 Oral communication
L. Franke (University of Groningen, Netherland)
12 :00 Bored by genetic risk factors? Interested in finding environmental risk factors instead?
Recycle genetic data
12:30 Lunch and Poster Session
SESSION 3 : Companion diagnostics and therapeutics
Dr. R. Wehrens (Wageningen University and Research center, Netherland)
02 :00
Merging Modelling Paradigms in Systems Biology
02 :30 Oral communication
Prof. A. Taieb (University of Bordeaux, France)
02:45
Personalized therapeutic strategies in atopic dermatitis
03 :15 Questionnaire delivery and End of meeting
5DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
3. Event outcome
3.1. General information
Analyses of gender balance showed that women were more represented during the meeting with 68
females and 40 males among the 108 participants (Figure 1). 10 invited speakers and 4 tutors from all
over Europe and United States presented highlights of interdisciplinary research, bridging biology,
medicine and human and social sciences with bioinformatics and modeling sciences in the workshop.
Among the participants were researchers, MDs, postdoctoral researchers, PhD students, and master
degree students. The majority of participants were from France.
Figure 1: Workshop participants according to gender, country and position (n = 108).
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
3.2. Survey statistics
Questionnaires were given to each participant (Appendix 7.1) and the outcomes are summarized
below.
3.2.1. Meeting and Workshop
Figure 2: Workshop survey questions and the distribution of answers (n = 32).
7DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Figure 2 (continued): Workshop survey questions and the distribution of answers (n = 32).
3.2.2. Open questionnaire
Outcome of the open questionnaire filled by participants attending the workshop (n = 17).
Answers were grouped and summarized accordingly.
1. What made you chose to attend the current workshop and what was the initial source of
information?
Thematic and topics of interest ; Increase scientific culture and vision ; Networking; Invited lecturer
; Recommendation from university and laboratory ; DHU 2020 mailing
2. What kind of association do you combine with Systems Medicine?
Organisms as a whole ; Statistics modelisation ; Data integration ;
Clinical approach ; Personalized medicine ; Explanatory medicine
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
3. Where do you see the beneficial aspects of Systems Medicine?
Understanding phenomena ;
Better organization of data and collection ;
Holistic view of organisms ;
Treating chronic / multifactorial diseases ;
Basis for decision support and adaptive care in precision medicine ;
Improving Personalized medicine
4. According to your opinion, in which disease area could Systems Medicine have the most impact?
Cancer ; Rare diseases ; Chronic diseases ; Complex and Multifactorial diseases that resist to more
classic ways of investigations
5. Have you visited the DHU 2020 website?
Figure 3 : Open questions and Visit of DHU 2020 website (n = 17).
6. What do the following terms mean to you - please try to give a short definition:
Systems Biology:
Integration of mechanisms ;
Multilevel modelling and approach to understand bio-mechanisms ;
Available tools able to improve scientific discoveries ;
New paradigm for scientific investigation stressing relations and connections rather than
components ;
Scientific discipline aiming at producing explanatory models of biological systems and pathologies
Systems Medicine:
Informatics approach with human data ;
New vision of medicine ;
Multilevel modelling to treat patients, prevent pathologies ;
A holistic view of organisms ;
Association of information on different diseases ;
Systems biology approach to treat patients
Personalized Medicine:
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Adaptive medicine ;
Patient tailored treatment/therapies and diagnostics ;
New vision of medicine putting emphasis on the specifics of each individuals
3.3. Workshops
During the meeting, two series of 4 workshops have been organized successively, to allow
participants to attend at least 2 workshops.
A total of 68 Participants attended the workshops, where 4 tutors were at the student’s disposal. The
tutors were professors from local institutions who were responsible for the preparation of the course
materials for students.
Participants in WS 4 were requested to bring their own laptop computers.
WS 01 WS 02 WS 03 WS 04
Tutors Dr. G. Meurette Dr. C. Dina Prof. P-A. Gourraud Dr. X. Prieur
Thematic Pig model as a new Making sens out of Personalized Using omics to
platform to develop GWAs Medicine starter in modelise metabolic
the neuro- a box abnormalities
intervention in
digestive diseases
Number of 15 18 45 32
participants
Figure 4 : Workshop thematic and number of participants.
The workshop of G. Meurette was about the use of pig model as a preclinical platform to develop
neuro-intervention in dysfunctions of the enteric nervous system. Despite the interest of the topic,
only a few students participated to this tutorial, as it was a very targeted and specific course.
C. Dina presented Genome-wide association studies (GWAS) and discuss how it can help unravel the
molecular mechanisms through which genetic variation causes disease.
Participants could follow step by step a GWAs analysis, evaluate the results and review various tools
(bibliography, public databases) to identify pathways involved in human diseases. It was a good
hands-on tutorial.
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
The general opinion of participants was that P-A Gourraud presented a very stimulating and
interactive workshop session, as evidenced by the number of participants. He dealt with the
personalized medicine tools alike the Multiple Sclerosis Bioscreen developed by UCSF-Neurology and
proposed to advance the assessment of data (existing datasets), Information technology (data
processing, storage and access) and analytics needs (descriptive, comparative and predictive
models).
The last workshop was presented by X. Prieur around metabolic diseases. He also had a great
success. Participants could interactively use omics data from different adipose tissue cell type and
practice to understand how to modelise this pathological state, under tutor supervision.
Overall, the workshop participation was a success (63% of meeting participants) and participants
were very enthusiastic about the topics and how the workshops were conducted.
3.4. Oral presentations and poster session
A part of the interactivity of the event was Oral presentations and poster sessions.
Concerning oral presentations, the selected speakers had 15 minutes for their presentation and
questions. Chairmen were asked to run an active discussion among students and participants.
Dealing with poster session, 8 abstracts were received and reviewed by the local scientific
committee. Among them, 7 abstracts were selected to be presented as poster. 1 abstract was
refused because it was off topic.
Students selected had 5 minutes to present their work and 4 tutors chosen among the local scientific
committee were asked to challenge students with questions.
The common opinion was that presentations selected were on a high scientific level and well-
presented and students participated successfully to the discussion.
One negative point may however be stressed: the low number of abstracts submitted, perhaps due
to the short time between the request mailing and the event.
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Figure 5 : Extract of posters presented during the poster session.
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
4. List of participants
PARTICIPANTS
SURNAME FIRST NAME INSTITUTION
Abramatic Severine Inserm UMR1087 / CNRS UMR6291
Amosse Emeline Inserm UMR1087 / CNRS UMR6291
Bailly Clément CHU de Nantes
Barbarot Sebastien CHU de Nantes
Barrak Elias CHU de Nantes
Basset Aude Université de Nantes
Bessard Anne INSERM UMR 913
Bihouee Audrey Université de Nantes
Bourgain Catherine Cermes3 - Inserm UMR988
Bourgeois Nathalie INSERM
Busson Pierre-François Inserm UMR1087 / CNRS UMR6291
Cariou Bertrand Inserm - CHU de Nantes
Carrere Marine Inserm UMR1087 / CNRS UMR6291
Castan Laure Inserm UMR1087 / CNRS UMR6291
Castro Claire l'institut du Thorax
l'institut du thorax
Charpentier Flavien
Inserm UMR1087 / CNRS UMR6291
Charrier Marine Université de Nantes
Chatel Stephanie Inserm UMR1087 / CNRS UMR6291
Colas Luc CHU de Nantes
Corbille Anne-Gaelle Université de Nantes
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Dansette Delphine Université de Nantes
Daumy Xavier l'institut du thorax
De Visme Sophie INSERM
Desmoulin-Canselier Sonia CNRS
Dina Christian l'institut du thorax
Dubé Justine Université de Nantes
Durand Eugenie Inserm UMR1087 / CNRS UMR6291
Even Amandine Université de Nantes
Fantou Aurélie CHU Nantes
Fauchet Camille CHU Nantes
Fellah Imen l'institut du thorax
Fonteneau Andréa Inserm UMR1087 / CNRS UMR6291
Foureau Aurore CIC Thorax - CHU de Nantes
Department of Genetics
Franke Lude
University Medical Centre Groningen
Freuchet Antoine Université de Nantes
Gaignard Alban CHU de Nantes
Garcon Damien Université de Nantes
Gibaud Bernard Unite U1099 LTSI - Université de Rennes 1
Gourraud Pierre Antoine Inserm UMR 1064
Guillonneau Carole Inserm UMR 1064
Guilloteau Perrine SFR - INSERM UMS 016 - CNRS UMS 3556
Guilluy Christophe Inserm UMR1087 / CNRS UMR6291
l'institut du thorax
Guyomarch Béatrice
Inserm UMR1087 / CNRS UMR6291
Hanf Matthieu CHU de Nantes / Inserm
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Hardy Anne Chantal DCS - CNRS UMR 6297
Henrio Kelly Inserm UMR1087 / CNRS UMR6291
Herbreteau Guillaume Université de Nantes
Hilleriteau Marie-Alice Université de Nantes
Hussler Sophie Université de Nantes
Javaudin François Université Nantes / CHU Nantes
l'institut du thorax
Jouni Mariam
Inserm UMR1087 / CNRS UMR 6291
INSERM UMR_S 999
Jutant Etienne Marie
Centre Chirurgical M.Lannelongue
Karakachoff Matilde l'institut du thorax, UMR Inserm 1087 / CNRS 6291
Lamirault Guillaume l'institut du thorax, UMR Inserm 1087 / CNRS 6291
Lancien Mélanie Université de Nantes
Le Louarn Anne CHU de Nantes
l'institut du thorax
Le May Cédric
Inserm UMR1087 / CNRS UMR6291
Le Tallec Noémie Université de Nantes
Le Vacon Francoise BIOFORTIS
l'institut du thorax
Lemarchand Patricia
Inserm UMR1087 / CNRS UMR6291
Leroy Solène Université de Nantes
Leveque Antoine Inserm UMR1087 / CNRS UMR6291
l'institut du thorax
Loirand Gervaise
Inserm UMR1087 / CNRS UMR6291
Loy Jennifer Inserm UMR1087 / CNRS UMR6291
Lund Pauline University of North Carolina
Magnan Antoine l'institut du thorax - CHU de Nantes
l'institut du thorax
Magre Jocelyne
Inserm UMR1087 / CNRS UMR 6291
Mallard Laëtitia Université de Nantes
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Marche Kévin Université de Nantes
Meurette Guillaume IMAD - CHU de Nantes
Moreau Virginie Université de Nantes
Morice Sarah Université de Nantes
Navarro Anne Sophie Université de Nantes
l'institut du thorax
Papin Mélanie
Inserm UMR1087 / CNRSUMR6291
Persyn Elodie l'institut du thorax
Pichelin Matthieu l'institut du Thorax - CHU de Nantes
Pichon Julien Université de Nantes
Pison Christophe CHU de Grenoble / Inserm U1055
Pochard Camille Inserm UMR 913
Pockpa Zocko Ange Desire Université de Nantes
Pontus Gilyane l'institut du Thorax
Prieur Xavier l'institut du thorax
Rannou Alice Université de Nantes
Renault Sarah LPRO - Inserm UMR 957
Richard Chrystelle CHU de Nantes
Rivière Pauline Université de Nantes
Rolli-Derkinderen Malvyne IMAD - Inserm UMR 913
Rousseau Thomas Université de Nantes
Royer Pierre Inserm UMR1087 / CNRS UMR6291
Royer Moes Anne CHU de Nantes
Institute of Biochemistry
Rozman Damjana
University of Ljubljana
IMAD
Sacher Huvelin Sylvie
CHU de Nantes
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
Sado Pierre-Etienne IMAD
Salam Idriss Inserm UMR1087 / CNRS UMR6291
Simonet Floriane Inserm UMR1087 / CNRS UMR6291
Si-Tayeb Karim Inserm UMR1087 / CNRS UMR6291
Steenman Marja l'institut du thorax
Inserm U1035
Taieb Alain
Université de Bordeaux
Takoudju Céline Université de Nantes
Tossé Lindzy l'institut du thorax
Van Landeghem Laurianne Inserm UMR 913
Vidal Luciano Université de nantes
Violland Mathilde Université de nantes
Institute of Metabolic Sciences
Virtue Samuel
University of Cambridge
Biometris
Wehrens Ronald
Wageningen University
Wiertlewski Sandrine CHU de Nantes
Wyart Vincent IMAD - CHU de Nantes
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
5. Conclusion
To conclude, we can say that the 2nd DHU 2020 Autumn school “from systems biology to new targets
and therapeutics” was a very exciting meeting, with high-level speakers and focus on successful
examples of research and practice of systems medicine.
According to the survey and questionnaire, the attempts were very successful and useful for all
participants and trainees.
Concerning the participation, there were fewer participants than for the first edition (108 vs 120
participants in 2014), but with more graduate and post-graduate students, thus reaching the
teaching objectives of this DHU2020 Autumn school.
Although very fruitful in terms of local and national networking, we can point out that there have
been little foreign participants except invited speakers.
Finally, given the success of this edition and that of the previous year, this event will be renewed
under the same format in autumn 2016, probably by coupling the meeting with European networks
sessions, in order to attract foreign participants.
18 DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
6. Acknowledgements
The event DHU 2020 Autumn School “From systems biology to new targets and therapeutics” was
supported by the CASyM initiative.
Steering Committee
The following officials, as part of the Scientific Steering Committee, are involved in the scientific
coordination of DHU 2020 :
Stanislas Bruley des Varannes – IMAD Director
Bertrand Cariou – l’institut du thorax Director
Dominique Darmaun
Anne Chantal Hardy
Hervé Le Marec
Gervaise Loirand
Antoine Magnan
Michel Neunlist
Patricia Parnet
Richard Redon
Sylvie Sacher-Huvelin
Jean-Noel Trochu
Administrative office (Coordination) of DHU 2020 Autumn school
Karine Botturi-Cavaillès - Project Management DHU 2020
Direction de la Recherche
Département Partenariats et Innovations, Nantes, France
Local scientific and organising committee
Head
Antoine Magnan – DHU 2020, CHU de Nantes, France
Members
Malvyne Rolli-Derkinderen – IMAD, Inserm UMR 913, France
Christian Dina – l’institut du thorax, Inserm UMR 1087, CNRS UMR 6291, France
Anne Chantal Hardy – Law and Social Change, CNRS UMR 6297 "Law and Social Change", France
Guillaume Meurette – IMAD, Inserm UMR 913, France
Xavier Prieur – l’institut du thorax, Inserm UMR 1087, CNRS UMR 6291, France
Christophe Guilly – l’institut du thorax, Inserm UMR 1087, CNRS UMR 6291, France
Guillaume Lamirault – l’institut du thorax, Inserm UMR 1087, CNRS UMR 6291, France
Sébastien Barbarot – IMAD, Inserm UMR 913, France
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
7. Appendix
7.1. Survey and questionnaire
Male undergraduate MD
Female graduate PhD
No statement Master
Please state your nationality
Please state your course of study
I totally I would not
Overall evaluation I agree Neutral I decline
agree recommend it
The training event was helpful for my
future career and I would recommend
it to fellow students
Organisation
The event was well organized
Course rooms were well equipped
with appropriate media technology
I could find specific courses easily
Courses started and ended at time
Speaker/Tutors
Topics were well addressed
Presentations were of high quality
Speakers/Tutors were well prepared
Speakers interacted well with
audience
Discussions
I could follow the discussions
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DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
I did make a contribution to the
discussion
The discussion were well chaired
Practical courses
The offered courses were useful
7.2. Open questionnaire
1- What made you chose to attend the current workshop and what was the initial
source of information?
2- What kind of association do you combine with Systems Biology ?
3- Where do you see the beneficial aspects of Systems Biology?
4- According to your opinion, in which disease area could Systems Biology have the
most impact?
5- Have you visited the DHU 2020 Website?
6- What do the following terms mean to you – please try to give a short definition :
Systems Biology:
Systems Medicine:
Personalized Medicine:
21 DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
7.3. Application procedure for EACCME accreditation
22 DHU 2020 training event
DHU 2020 Autumn school “From systems biology to new targets and therapeutics”
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