COVER DESIGN - Penn Veterinary Supply, Inc.

 
COVER DESIGN - Penn Veterinary Supply, Inc.
COVER DESIGN
COVER DESIGN - Penn Veterinary Supply, Inc.
Double Defense Uses:
                         Vectra® 3D for Dogs which has a 99.1 %
                         anti-feeding efficacy against mosquitoes 1
                         A heartworm preventive to kill
                         heartworm larvae

                      Dogs protected with Double Defense protocol
                               had no adult heartworms
                                                                                                                                                                                                                       1,2

                                                                                                                                        Number of Dogs                                                                                 Average Number
                                   Groups                                                                                                                                                                                            of Adult Heartworms
                                                                                                                                        with Heartworms
                                                                                                                                                                                                                                           Per Dog

                                                                   Control                                         + + + + + + + +                                                                                                                     41
                                    Vectra® 3D Only                                                                + + +                                                                                                                               1.5
                                Milbemycin Only                                                                    + + + + + + + +                                                                                                                     17.1
                 DOUBLE DEFENSE
                   Vectra® 3D and Milbemycin                                                                                                   0 Dogs                                                                                                  0

                                                                                  Learn why Vectra® 3D and Double Defense
                                                                                  make sense for your practice at
                                                                                  FightHeartwormNow.com
             DO NOT USE VECTRA® 3D ON CATS ©2018 Ceva Animal Health, LLC
             Vectra® and Vectra® 3D logo are registered trademarks of Ceva Animal Health, LLC
             Double Defense logo trademark is the property of Ceva Animal Health, LLC

             1. McCall, J.W., Hodgkins, E., Varloud, M., Mansour, A., DiCosty, U., McCall, S., Carmichael, J., Carson, B., & Carter, J. (2016, August). Blocking of the transmission of Dirofilaria immitis L3 (JYD-34 ML resistant strain) from in-
             fected mosquitoes to dogs and prevention of infection in dogs treated topically with dinotefuran-permethrin-pyriproxyfen and orally with milbemycin oxime alone or in combination. In 61st Annual Meeting Proceedings: American
             Association of Veterinary Parasitologists- 61st Annual Meeting. San Antonio, TX. Abstract No. 21, 61.

             2. McCall, J.W., Hodgkins, E., Varloud, M., Mansour, A., & DiCosty, U. (2015, July). Inhibition of the transmission of Dirofilaria immitis to mosquitoes by weekly exposure to microfilaremic dogs treated topically with
             dinotefuran-permethrin-pyriproxyfen to uninfected Aedes aegypti. In Annual Meeting Proceedings: American Association of Veterinary Parasitologists- 60th Annual Meeting. Boston, MA. Abstract No. 7, 59.

2 | Penn Veterinary Supply | March-April 2019                                                                                        			                                                                                     1-800-233-0210 | www.pennvet.com
COVER DESIGN - Penn Veterinary Supply, Inc.
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COVER DESIGN - Penn Veterinary Supply, Inc.
Ticks and fleas CAN
                                                                                                                         turn my world

                                                                                                   Down          Up s i d e
         Calling All Dogs, BIG and Small! Credelio is available in five convenient SKUs
         for dogs 4.4 to 100 pounds.
         Talk to your Elanco sales representative for more information
         and to place your order today.                                                                                             SKU Available for
         Indications
         Credelio kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the         BIG Dogs
                                                                                                                                    50.1-100 lbs!
         treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American
         dog tick), Ixodes scapularis (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs
         and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

         Important Safety Information
         The safe use of Credelio in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with
         a history of seizures. The most frequently reported adverse reactions are weight loss, elevated blood urea nitrogen,
         excessive urination, and diarrhea. For product information, including complete safety information, see page 44.
                                                                                                                      XX.

         Credelio, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
         © 2019 Elanco or its affiliates. PM-US-19-0027

4 | Penn Veterinary Supply | March-April 2019                                                     			                             1-800-233-0210 | www.pennvet.com
12925_01_Credelio_900_Trade_Ad_PennVet_8.625x11.indd 1                                                                                                     2/1/19 4:02 PM
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COVER DESIGN - Penn Veterinary Supply, Inc.
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COVER DESIGN - Penn Veterinary Supply, Inc.
Please see prescribing Information on page 42.

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COVER DESIGN - Penn Veterinary Supply, Inc.
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COVER DESIGN - Penn Veterinary Supply, Inc.
46.

10 | Penn Veterinary Supply | March-April 2019   			   1-800-233-0210 | www.pennvet.com
For your FREE digital copy of this handout, contact your Penn Vet Rep today!
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LEPTOSPIROSIS
           IS A SMALL
             SIP AWAY
                                                                Get full size
                                                                  protection
                                                               in a half size
                                                                     vaccine

             Nobivac EDGE™ Lepto4 is the FIRST and ONLY 0.5 ml Leptospirosis vaccine
                to help prevent mortality and urinary shedding for dogs of all sizes.1

18 | Penn Veterinary Supply | March-April 2019   			                 1-800-233-0210 | www.pennvet.com
99% Reaction Free
   CUTTING EDGE PROTECTION...                                                                                                 Out of 1583 Doses Given in
                                                                                                                              Clinical Impressions Study1

                                                                                          Applied pressure

          NEW NOBIVAC 0.5 ml VACCINES
                                                                                                                       Purified
             • Full protection, half the injection volume                                                              solution

               (50% less volume than standard vaccines)                                    Filtration membrane                         Filtration membrane

             • Proven protection for dogs of all sizes                                     BEFORE                    Extraneous         AFTER
                                                                                                                      proteins         FILTRATION
                                                                                           FILTRATION
             • VacciPure™ Technology supports vaccine safety
                                                                                          VACCIPURE™ FILTRATION TECHNOLOGY1

               NOBIVAC EDGE™                                    NOBIVAC EDGE™                                          NOBIVAC EDGE™
                  LEPTO4                                          DAPPv + L4                                               DAPPv
      • First 0.5 ml Leptospirosis                    • First 0.5 ml combo vaccine                            • First 0.5 ml combo vaccine
        vaccine shown to be effective                   to include parainfluenza                                to include parainfluenza
        against disease, mortality and                  protection1                                             protection1
        shedding1                                     • First 0.5 ml Leptospirosis
                                                        combo vaccine shown to be
                                                        effective against disease,
                                                        mortality and shedding1

             TOTAL PROTEIN TESTING RESULTS FOR 0.5 ML VACCINES
             Average Total Protein (mg/dose)

             NOBIVAC EDGE™ DAPPv+L4                                                                    5.0 mg/dose

             ULTRA™ DURAMUNE® DAP+4L                                                                                   5.8 mg/dose
             Product is registered trademark
             of respective owner.                 mg            1               2          3                     4                 5                     6

          “While the decrease from 1 ml to 0.5 ml doesn’t sound like a lot, the ease of administration is notable. Not all
          vaccines are equal. The difference between injecting 0.5 ml and 1 ml when you have a puppy and 2-3 vaccines
          to give, you barely notice you’ve injected the volume. With the 0.5 ml vaccine, there was much less vocalization,
          and much less spilled vaccine. Thumbs-up from us for using NOBIVAC EDGE vaccines.”             TM

                                                                                – Dr. Trathan, Oakdale Veterinary Group, Oakdale, CA

   Reference: 1. Data on file, Merck Animal Health.
   Copyright © 2018 Intervet Inc., d/b/a Merck Animal Health, a subsidiary of
   Merck & Co., Inc. All rights reserved. US/NCA/1118/0005

1-800-233-0210 | www.pennvet.com                                                                    Penn Veterinary Supply | March-April 2019 | 19
Introducing
      Elanco Portfolio Rewards
      Valid on cumulative purchases
      Jan 1 - Mar 31, 2019

      A Portfolio That Pays You Back
      Choosing the right products to meet your patients’ needs has never been more rewarding.
      Increasing your use of our best-selling products qualifies you for bigger savings.

                                  Purchase one or a mix of these key Elanco products to receive the following rebates:

       GROUP 1
      PRODUCTS

       GROUP 2
      PRODUCTS

                Cumulative Spend                    $ 5,000-          $15,000-          $ 20,000-          $ 30,000-
              Any combination of products
                                                    $14,999            $19,999           $ 29,999           $ 39,999
                                                                                                                             ≥$40,000
                   from either group

                           Rebate Earned
                                                               1%                                   2%                          3%
      GROUP 1 PRODUCTS

                             SPOTLIGHT
                               BONUS              Purchase $2,500 of Credelio to receive a 1% additional rebate on all group 1 products!

                          Total Rebate Earned
                          with Spotlight Bonus                 2%                                   3%                          4%
                           Rebate Earned
                                                     10%                15%               20%                25%               30%
       GROUP 2 PRODUCTS

                             SPOTLIGHT           Purchase $2,500 of ULTRA Duramune, ULTRA Fel-O-Vax, ULTRA Hybrid FVRCP, ULTRA Duramune
                               BONUS              Lyme and/or Bronchi-Shield ORAL to receive a 5% additional rebate on all group 2 products!

                                                     15%               20%                25%                30%               35%
                          Total Rebate Earned
                          with Spotlight Bonus

      Here’s how it works:
                          • Purchase one product or mix and match multiple Elanco products in group 1 and group 2
                          • Rebates will be issued quarterly
                          • Purchase specific products to unlock Spotlight Bonuses

20 | Penn Veterinary Supply | March-April 2019                                			                             1-800-233-0210 | www.pennvet.com
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 21
22 | Penn Veterinary Supply | March-April 2019   			   1-800-233-0210 | www.pennvet.com
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 23
FEATURED PROMOTIONS
                              PROMOTIONS
VENDOR                END DATE ITEMS                                        PROMOTION
                                                                            Purchase Avagard antiseptic hand prep and get a free wall
3M                    12/31/2019   Avagard
                                                                            bracket and foot pump or a wall bracket and hand pump.
                                                                            Purchase 20 tests, receive a free VUE, cPL Starter Kit, and
Abaxis                3/31/2019    VetScan cPL Rapid Tests
                                                                            Andriod Mobile Device
                                                                            Buy 25 VetScan UA14 strips and get 50% off your VetScan UA
                      3/31/2019    VetScan UA Urine Analyzer
                                                                            analyzer.
Andover Healthcare    4/30/2019    PetFlex                                  Buy any 2 boxes of PetFlex and get one 6‐pack sample box.
                                   Adaptil and Feliway Pheromone
Ceva                  3/31/2019                                             Buy 3, get 1 free. Mix and match.
                                   Products
                      3/31/2019    Catego                                   Buy 3 cartons, get 1 carton free. Mix and match.

                      3/31/2019    Clenz‐a‐dent & Breakables Products       Buy 1, get 1 free. Mix and match.

                      3/31/2019    MilbeGuard                               Buy 1 carton of each size, get 1 carton of each size free.

                      3/31/2019    Vectra & Vectra 3D                       Buy 3 cartons, get 1 carton free. Mix and match.
                                   Fuzion, Hydrogen Peroxide, and
Clorox Healthcare     3/31/2019                                             Buy 2, get 1 free. Kind for kind.
                                   Disinfecting Bio Stain & Odor Remover
Datamars              4/30/2019    PetLink Slim Microchips                  Buy 50 microchips, get 10 microchips free.

Dechra                3/31/2019    Carprofen Injection                      Buy 3, get 1 free.

                      3/31/2019    Carprofen Caplets                        Buy 4, get 1 free. Mix and match.
                                                                            Buy 4, get 1 free plus 1 free bottle of Carprovet Flavored Tablets
                      3/31/2019    Carprofen Chew Tabs
                                                                            100mg.
                      3/31/2019    Carprovet Flavored Tabs                  Buy 3, get 1 free. Mix and match.

                      3/31/2019    Cefpodoxime Proxetil Tabs                Buy 3, get 1 free. Mix and match.

                      3/31/2019    DentAcetic, DenTees, and VetraDent       Buy 2, get 1 free. Mix and match.

                      3/31/2019    Eicosa 3FF, EicosaCaps, and EicosaDerm Buy 5, get 1 free. Kind for kind.

                      3/31/2019    Vetropolycin & Vetropolycin HC           Buy 4, get 1 free. Kind for kind.

Merck                 4/30/2019    Tri‐Heart Plus                           Buy 5 cartons, get 2 cartons free. Mix and match.
                                                                            Buy 4, get 1 free. Mix and match. Includes the new 2x100mL
Norbrook              3/31/2019    Loxicom Oral Suspension
                                                                            size!
                                                                            For every $2,200 in purchases of Nutramax products made
Nutramax              3/31/2019    First Quarter Promotion                  between January 1 , 2019 ‐ March 31, 2019, receive a Nutramax
                                                                            branded LiT Firefly TS‐300 cooler free.
                                                                            Purchase $375 of Denamarin Advanced and get one 21ct. box of
                      3/31/2019    Denamarin Advanced                       Crananidine Chewable Tablets and one 75ct. box of Crananidin
                                                                            Chewable Tablets free.
                                   Vet25 and Vet30 Blood Pressure
SunTech               3/31/2019                                             Receive an extra set of blood pressure cuffs free with purchase.
                                   Monitors
Vedco                 6/30/2019    CeftiFlex Injection                      Buy 11, get 1 free. Kind for kind.

                      3/31/2019    ClotIt                                   Buy 4, get 2 free. Kind for kind.
                                   MicroSpore Leave‐on Lotion, Micro BP
                      3/31/2019                                             Buy 4, get 1 free. Kind for kind.
                                   Shampoo, Micro BP Gel
                      3/31/2019    Novox Caplets                            Buy 4, get 1 free. Mix and match.

                      3/31/2019    Novox Chewable Tablets                   Buy one 180ct. bottle, get one 60ct. bottle free.

Vetoquinol            3/31/2019    pH‐Notix                                 Buy 9, get 3 free.
                                                                            Buy $1,750 cumulatively in Vetprofen before March 31, 2019 and
                      3/31/2019    Vetprofen
24 | Penn Veterinary Supply | March-April 2019                  			         get a pair of BLORX X‐ray1-800-233-0210
                                                                                                      gloves free.     | www.pennvet.com
                                                                            Buy $1,500 of Iverhart, get a 10% rebate; Buy $3,500 of Sentinel,
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 25
26 | Penn Veterinary Supply | March-April 2019   			   1-800-233-0210 | www.pennvet.com
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28 | Penn Veterinary Supply | March-April 2019   			   1-800-233-0210 | www.pennvet.com
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 29
Introducing the

                                                                                                  FLEX4 Rapid Test
                   Now you have a choice. The VetScan Canine FLEX4 Rapid Test delivers all the benefits of the single
                   Rapid Tests in one simple package. With four tests on one cassette, performing a comprehensive heartworm
                        and tick panel has never been easier or more cost-effective. Check out some of the features below:

                                       8 reasons thousands of veterinary
                                     hospitals have switched to the FLEX4

             3 simple, intuitive steps                                                                                                                         Easy-to-read results
                                                                                        Lyme                     Anaplasma

        Room temperature storage                                                                                                                               8 minutes to result

                       1-year shelf life                                                                                                                       Proven lateral flow technology
                                                                            Heartworm                            Ehrlichia
                  2 drops of sample
                  6 drops of 1 buffer                                                                                                                          Staff friendly

                                                    Contact your Authorized Distributor to order today.

                                                                                  www.abaxis.com/flex4
                                     VetScan Rapid Tests are intended for veterinary use only. Abaxis and VetScan are registered trademarks of Abaxis, Inc. © Abaxis 2018.

   | Penn Veterinary Supply | March-April
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                                                                                                                                                                                    7/24/18 4:59 PM
From Norbrook...
                                                                                                                                                                                                                                                                     ®

                                                                                                                                                 Loxicom Oral Suspension
                                                                                                                                                                                                ®

                                                                                                                                                  2 x 100 mL Size
                                                                                                                                                                                                  Each Carton Contains:
                                                                                                                                                                                                  • 2 Bottles of Loxicom Oral Suspension 100 mL
                                                                                                                                                                                                  • 1 Calibrated Syringe for Dogs 30 lbs and Under;
                                                                                                                                                                                                    1 Calibrated Syringe for Dogs 30 lbs and Over
                                                                                                                                                                                                  • 1 Package Insert

                      For More Information Contact
                         Your Distributor or Call
                       Norbrook at (888) 705-0408

                                                                                                                                                                           Key Benef its:
                                                                                                                                                                        ◊ Contains the same active ingredient and is bioequivalent
                                                                                                                                                                          to Metacam® (meloxicam) Oral Suspension
                                                                                                                                                                        ◊ Available in convenient 10 mL, 32 mL, 100 mL and
                                                                                                                                                                          new 2 x 100 mL sizes in 1.5mg strength
                                                                                                                                                                        ◊ Choosing to carry Loxicom® Oral Suspension over
                                                                                                                                                                          Metacam® Oral Suspension allows you to eliminate
                                                                                                                                                                          inventory (i.e. 0.5mg sizes) from your pharmacy
                                                                                                                                                                        ◊ Reduces your dispensing costs across all weight
                                                                                                                                                                          ranges of dogs

                                                                                                            Save versus other meloxicam
                                                                                                            suspension brand econo sizes:

                                                                                                                                               Loxicom® Metacam® *Savings                                                       Meloxidyl® *Savings
                                                                                                                                              2 x 100 mL 180 mL with Loxicom®                                                    200 mL with Loxicom®
                                                                                                                Cost Per Carton                  $92.34                $109.80                     $29.66                         $95.15                 $2.81
                                                                                                                   Cost Per mL                   $0.46                    $0.61                                                     $0.48

     www.norbrook.com                                                                                         *Loxicom savings calculated based on 200 mLs of Metacam
                                                                                                              Source: 2018 DVM list price

     Observe label directions. Do not use Loxicom Oral Suspension in cats. Acute renal failure and death have been associated with the use of meloxicam in cats. As with any medication, side effects may occur. These are usually mild, but may be serious. The most common side
     effects reported in field studies were vomiting, soft stool/diarrhea and decreased appetite. If side effects occur, discontinue treatment immediately and consult a veterinarian. Dogs should be evaluated for pre-existing medical conditions prior to treatment and monitored
     during therapy. See product labeling for full product information.
     The Norbrook logos and Loxicom are registered trademarks of Norbrook Laboratories Limited. Metacam is a registered trademark of Boehringer Ingelheim Vetmedica, Inc. Meloxidyl is a registered trademark of Ceva Sante Animale S.A. 0818-497-I01A

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Want to know more?                                                                                                                                           ERIN
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        for a FREE Lunch & Learn

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                                        Nutritional Management Guide – Canine
                Category           Products                 Indications                                              Key Benefits                                   Life Stage          Top 5 Ingredients
                                                  •    Acute or chronic gastroenteritis       •    Clinically shown to improve stool quality                          Puppy and       DRY FOOD:
                                                  •    Inflammatory bowel disease                  with 23% quicker resolution of diarrhea                              Adult         1. Deboned Chicken
                                                  •    Motility/emptying disorders                                                                                                    2. Chicken Meal
                                                                                              •    Clinically shown to produce ideal fecal

                 GI
                                                  •    Protein-losing enteropathy                                                                                                     3. Oatmeal
                                                                                                   consistency scores
                                                  •    Antibiotic-responsive diarrhea                                                                                                 4. Brown Rice
                                                  •    Small and large bowel diarrhea         •    Prebiotic fibers and fermentation extracts to                     Note: Canned     5. Peas
                                                  •    Exocrine pancreatic                         promote GI health                                                     food not
                                                       insufficiency                          •    Complete and balanced nutrition                                    intended for    WET FOOD:
                                                  •    Colitis                                                                                                         large breed    1. Chicken
             GASTROINTESTINAL                     •    Pancreatitis                                                                                                      puppies      2. Chicken Broth
                                                       (non-hyperlipidemic)                                                                                                           3. Chicken Liver
                 SUPPORT                          •    Constipation                                                                                                                   4. Potatoes
                                                                                                                                                                                      5. Whitefish

                                                  Dermatologic:                               •    Features highly digestible salmon hydrolysate                        Adult         DRY FOOD:
                                                  •   Chronic Otitis Externa                       to help minimize the chances of adverse                                            1. Salmon Hydrolysate
                                                  •   Cutaneous Adverse Food                       reactions to food                                                                  2. Pea Starch
                                                      Reactions (CAFR)                                                                                                                3. Potatoes
                                                                                              •    Enriched with omega-3 fatty acids which have
                                                  •   Chronic Non-Seasonal Pruritic                                                                                                   4. Peas
                                                                                                   been shown to reduce inflammation in skin cells

                HF
                                                      Dermatitis                                                                                                                      5. Pea Protein
                                                                                              •    Complete and balanced nutrition
                                                  Gastrointestinal:
                                                                                                                                                                                      WET FOOD:
                                                  •    Diet-Responsive Chronic
                                                                                                                                                                                      1. Salmon Hydrolysate
                                                       Enteropathy
                                                                                                                                                                                      2. Water
                                                  •    Chronic Gastroenteropathy
             FOOD INTOLERANCE                     •    Intestinal Dysbiosis
                                                                                                                                                                                      3. Potato Starch
                                                                                                                                                                                      4. Natural Flavor
                                                  •    Colitis
                                                                                                                                                                                      5. Pea Fiber
                                                  Other Inflammatory Conditions:
                                                  •   Atopic Dermatitis
                                                  •   Pruritic Dermatitis

                                                  •    Kidney disease                         •    Controlled protein and mineral levels to help                         Adult        DRY FOOD:
                                                  •    Calcium oxalate urolithiasis                manage kidney disease                                                              1. Deboned Chicken

                KS
                                                                                                                                                                                      2. Pea Starch
                                                  Contraindications:                          •    Clinically proven to produce a Calcium Oxalate Supersatu-
                                                                                                                                                                                      3. Potato Starch
                                                  •   Struvite urolithiasis                        ration value of
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                                    Nutritional Management Guide – Feline
              Category        Products                         Indications                                           Key Benefits                                 Life Stage           Top 5 Ingredients
                                                     •    Acute or chronic gastroenteritis    •    Clinically shown to improve stool quality with                     Dry: Adult     DRY FOOD:
                                                     •    Inflammatory bowel disease               29% quicker resolution of diarrhea                                                1. Deboned Chicken
                                                     •    Motility/emptying disorders                                                                                                2. Chicken Meal
                                                                                              •    Clinically shown to produce ideal fecal                         Wet: Kitten

              GI
                                                     •    Protein-losing enteropathy                                                                                                 3. Tapioca Starch
                                                                                                   consistency scores                                              and Adult
                                                     •    Antibiotic-responsive diarrhea                                                                                             4. Peas
                                                     •    Small and large bowel diarrhea      •    Prebiotic fibers and fermentation extracts to promote GI                          5. Turkey Meal
                                                     •    Exocrine pancreatic                      health
                                                          insufficiency                       •    Complete and balanced nutrition                                                   WET FOOD:
                                                     •    Colitis                                                                                                                    1. Chicken
          GASTROINTESTINAL                           •    Pancreatitis                                                                                                               2. Chicken Broth
                                                     •    Constipation                                                                                                               3. Chicken Liver
              SUPPORT                                                                                                                                                                4. Whitefish
                                                                                                                                                                                     5. Potatoes

                                                     Dermatologic:                            •    Features highly digestible salmon hydrolysate                        Adult        DRY FOOD:
                                                     •    Chronic Otitis Externa                   to help minimize the chances of adverse reactions                                 1. Salmon Hydrolysate
                                                     •    Cutaneous Adverse Food                   to food                                                                           2. Peas
                                                          Reactions (CAFR)                    •    Enriched with omega-3 fatty acids which have                                      3. Potatoes
                                                     •    Eosinophilic Granulomatous               been shown to reduce inflammation in skin cells                                   4. Pea Starch

              HF
                                                          Disease                                                                                                                    5. Pea Protein
                                                     •    Chronic Non-Seasonal Pruritic       •    Complete and balanced nutrition
                                                          Dermatitis                                                                                                                 WET FOOD:
                                                     Gastrointestinal:                                                                                                               1. Salmon Hydrolysate
                                                     •    Diet-Responsive Chronic                                                                                                    2. Water
                                                                                                                                                                                     3. Potato Starch
          FOOD INTOLERANCE                           •
                                                          Enteropathy
                                                          Chronic Gastroenteropathy                                                                                                  4. Natural Flavor
                                                     •    Intestinal Dysbiosis                                                                                                       5. Pea Fiber
                                                     •    Colitis
                                                     Other Inflammatory Conditions:
                                                     •   Atopic Dermatitis
                                                     •   Pruritic Dermatitis

                                                     •    Kidney disease                      •    Controlled protein and mineral levels to help                        Adult        DRY FOOD:
                                                     •    Calcium oxalate urolithiasis             manage kidney disease                                                             1. Deboned Chicken
                                                     •    Joint disease                       •    Clinically proven to produce a Calcium Oxalate                                    2. Peas

            KM
                                                                                                                                                                                     3. Pea Starch
                                                     Contraindications:                            Supersaturation value of
NEW LOOK –
       The same product you’ve known to
       trust you can now order by name.

                                                                                                                                             Enroquin
                                                                                                                                                                TM

         OLD LABEL
                                                                                                                                             Flavored Tablets (enrofloxacin)

                                                                           NEW LABEL

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                      01AD-DEC50130-0219

38 | Penn Veterinary Supply | March-April 2019                                                   			                                                      1-800-233-0210 | www.pennvet.com
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 39
40 | Penn Veterinary Supply | March-April 2019   			   1-800-233-0210 | www.pennvet.com
1-800-233-0210 | www.pennvet.com   Penn Veterinary Supply | March-April 2019 | 41
recommended dose of milbemycin oxime (0.5 mg/kg). This product has not been tested in dogs less than 1 kg
                                                                                                                              weight.
                                                                                                                              A rising-dose safety study conducted in rough-coated collies, manifested a clinical reaction consisting of
                                                                                                                              ataxia, pyrexia and periodic recumbency, in one of fourteen dogs treated with milbemycin oxime at 12.5
                                                                                                                              mg/kg (25X monthly use rate). Prior to receiving the 12.5 mg/kg dose (25X monthly use rate) on day 56 of
                                                                                                                              the study, all animals had undergone an exaggerated dosing regimen consisting of 2.5 mg/kg milbemycin
                                   INFORMATION FOR DOSING DOGS                                                                oxime (5X monthly use rate) on day 0, followed by 5.0 mg/kg (10X monthly use rate) on day 14 and 10.0
    The once-a-month tablet that prevents heartworm disease, controls adult hookworm, and removes and controls                mg/kg (20X monthly use rate) on day 32. No adverse reactions were observed in any of the collies treated
    adult roundworm and whipworm infections in dogs and puppies.                                                              with this regimen up through the 10.0 mg/kg (20X monthly use rate) dose.
    Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Keep this and all    How supplied: MILBEGUARD Flavored Tablets are available in four tablet sizes (see Dosage section),
    drugs out of the reach of children.                                                                                       formulated according to the weight of the dog. Each tablet size is available in color-coded packages of 6
                                                                                                                              tablets each, which are packaged 10 per display carton.
    Description: MILBEGUARD (milbemycin oxime) Flavored Tablets are available in four tablet sizes in color-coded
    packages for oral administration to dogs and puppies. Each tablet is formulated to provide a minimum of 0.23 mg/lb        Storage conditions:         MILBEGUARD Flavored Tablets should be stored at room temperature, between
    (0.5 mg/kg) body weight of milbemycin oxime. Milbemycin oxime consists of the oxime derivatives of                        68° and 77°F (20-25°C).
    5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68).
                                                                                                                                                           INFORMATION FOR DOSING CATS
                       Package color                              Milbemycin oxime tablet
                               Yellow                                           2.3 mg*                                       The once-a-month tablet that prevents heartworm disease and removes adult roundworms and
                                Blue                                            5.75 mg                                       hookworms in cats and kittens.
                               Purple                                           11.5 mg                                       Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Keep
                                Red                                             23.0 mg                                       this and all drugs out of the reach of children.
    *for dogs only                                                                                                            Description: MILBEGUARD Flavored Tablets for Cats are available in three tablet sizes in color-coded
    Indications: MILBEGUARD Flavored Tablets are indicated for use in the prevention of heartworm disease caused by           packages for oral administration to cats and kittens. Each tablet is formulated to provide a minimum of 0.9
    Dirofilaria immitis, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult            mg/lb (2.0 mg/kg) body weight of milbemycin oxime. Milbemycin oxime consists of the oxime derivatives
    Toxocara canis and Toxascaris leonina (roundworms) and Trichuris vulpis (whipworm) infections in dogs and in              of 5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3
    puppies four weeks of age or greater and two pounds body weight or greater.                                               (C31H43NO7, MW 541.68).
    Dosage: MILBEGUARD Flavored Tablets are given orally, once a month, at the recommended minimum dosage rate                Indications: MILBEGUARD Flavored Tablets for Cats are indicated for use in the prevention of heartworm
    of 0.23 mg milbemycin oxime per pound of body weight (0.5 mg/kg).                                                         disease caused by Dirofilaria immitis, and the removal of adult Ancylostoma tubaeforme (hookworm) and
    Recommended Dosage Schedule for Dogs                                                                                      Toxocara cati (roundworm) in cats and kittens six weeks of age or greater and 1.5 lbs. body weight or greater.
                         Body Weight                        MILEBEGUARD Flavored Tablets                                      Dosage: MILBEGUARD Flavored Tablets for Cats are given orally, once a month, at the recommended
                              2-10 lbs.                                  One tablet (2.3 mg)                                  minimum dosage rate of 0.9 mg milbemycin oxime per pound of body weight (2.0mg/kg).
                             11-25 lbs.                                 One tablet (5.75 mg)                                  Recommended Dosage Schedule for Cats
                             26-50 lbs.                                 One tablet (11.5 mg)
                                                                                                                                               Body Weight                    MILEBEGUARD Flavored Tablets
                            51-100 lbs.                                 One tablet (23.0 mg)
                                                                                                                                                  1.5-6 lbs.                          One tablet (5.75 mg)
    Dogs over 100 Ibs. are provided the appropriate combination of tablets.                                                                      6.1-12 lbs.                          One tablet (11.5 mg)
    Administration: MILBEGUARD Flavored Tablets are dual-purpose and may be offered in food or administered as                                   12.1-25 lbs.                         One tablet (23.0 mg)
    other tablet medications. Watch the dog closely following dosing to be sure the entire dose has been consumed. If it is
    not entirely consumed, redose once with the full recommended dose as soon as possible.                                    Cats over 25 Ibs. are provided the appropriate combination of tablets.
    MILBEGUARD Flavored Tablets must be administered monthly, preferably on the same date each month. The first dose          Administration: MILBEGUARD Flavored Tablets for Cats may be offered in food or administered as other
    should be administered within one month of the dog’s first exposure to mosquitoes and monthly thereafter until the        tablet medications. The tablets can be broken for ease of administration. Watch the cat closely following
    end of the mosquito season. If a dose is missed and a 30-day interval between dosing is exceeded, administer              dosing to be sure the entire dose has been consumed. If it is not entirely consumed, redose once with the
    MILBEGUARD Flavored Tablets immediately and resume the monthly dosing schedule.                                           full recommended dose as soon as possible.
    If MILBEGUARD Flavored Tablets replaces diethylcarbamazine (DEC) for heartworm prevention, the first dose must be         MILBEGUARD Flavored Tablets for Cats must be administered monthly, preferably on the same date each
    given within 30 days after the last dose of DEC.                                                                          month. The first dose should be administered within one month of the cat’s first exposure to mosquitoes
    Precautions: Do not use in puppies less than four weeks of age or less than two pounds of body weight. Prior to           and monthly thereafter until the end of the mosquito season. If a dose is missed and a 30-day interval
    initiation of the MILBEGUARD Flavored Tablets treatment program, dogs should be tested for existing heartworm             between dosing is exceeded, administer MILBEGUARD Flavored Tablets for Cats immediately and resume
    infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment    the monthly dosing schedule. It is recommended that cats be tested for existing heartworm infection prior
    with MILBEGUARD Flavored Tablets. Mild, transient hypersensitivity reactions manifested as labored respiration,           to starting treatment with MILBEGUARD Flavored Tablets for Cats (See Precautions).
    vomiting, salivation and lethargy, have been noted in some treated dogs carrying a high number of circulating             Precautions: Do not use in kittens less than six weeks of age or less than 1.5 lbs. body weight. Safety in
    microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.              heartworm positive cats has not been established. Safety in breeding, pregnant, and lactating queens and
    Adverse Reactions: The following adverse reactions have been reported following the use of MILBEGUARD                     breeding toms has not been established.
    Flavored Tablets: Depression/lethargy, vomiting, ataxia, anorexia, diarrhea, convulsions, weakness and hypersalivation.   Efficacy: MILBEGUARD Flavored Tablets for Cats eliminate the tissue stage of heartworm larvae and
    Efficacy: MILBEGUARD Flavored Tablets eliminate the tissue stage of heartworm larvae and the adult stage of               hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections when administered orally
    hookworm (Ancylostoma caninum), roundworms (Toxocara canis, Toxascaris leonina) and whipworm (Trichuris                   according to the recommended dosage schedule. The anthelmintic activity of milbemycin oxime is believed
    vulpis) infestations when administered orally according to the recommended dosage schedule.The anthelmintic               to be a result of interference with invertebrate neurotransmission.
    activity of milbemycin oxime is believed to be a result of interference with invertebrate neurotransmission.              Safety: Milbemycin oxime has been tested safely in over 8 different breeds of cats. In well-controlled
    Safety: Milbemycin oxime has been tested safely in over 75 different breeds of dogs, including collies, pregnant          clinical field studies 141 cats completed treatment with milbemycin oxime. Milbemycin oxime was used
    females, breeding males and females, and puppies over two weeks of age. In well-controlled clinical field studies, 786    safely in animals receiving frequently used veterinary products such as vaccines, anthelmintics, anesthetics,
    dogs completed treatment with milbemycin oxime. Milbemycin oxime was used safely in animals receiving frequently          antibiotics, steroids, flea collars, shampoos and dips.
    used veterinary products such as vaccines, anthelmintics, antibiotics, steroids, flea collars, shampoos and dips.         Safety studies were conducted in young cats and kittens and doses of 1X, 3X and 5X the minimum
    Two studies in heartworm-infected dogs were conducted which demonstrated mild, transient hypersensitivity                 recommended dose of 2.0 mg/kg demonstrated no drug- related effects. Tolerability studies at exaggerated
    reactions in treated dogs with high microfilaremia counts (see Precautions for reactions observed). Safety studies in     doses of 10X also demonstrated no drug-related adverse effects in kittens and young adult cats.
    pregnant dogs demonstrated that high doses (1.5 mg/kg =3X) of milbemycin oxime given in an exaggerated dosing             How supplied: MILBEGUARD Flavored Tablets for Cats are available in three tablet sizes (see Dosage
    regimen (daily from mating through weaning), resulted in measurable concentrations of the drug in milk. Puppies           section), formulated according to the weight of the cat. Each tablet size is available in color-coded packages
    nursing these females which received exaggerated dosing regimens demonstrated milbemycin-related effects. These           of 6 tablets each, which are packaged 10 per display carton.
    effects were directly attributable to the exaggerated experimental dosing regimen. The product is normally intended       Storage conditions:           MILBEGUARD Flavored Tablets for Cats should be stored at room temperature,
    for once-a-month administration only. Subsequent studies included using 3X daily from mating to one week before           between 68° and 77°F (20-25°C).
    weaning and demonstrated no effects on the pregnant females or their litters. A second study where pregnant
                                                                                                                              Manufactured for:
    females were dosed once at 3X the monthly use rate either before, on the day of or shortly after whelping resulted in
                                                                                                                              Ceva Animal Health, LLC
    no effects on the puppies.
                                                                                                                              Lenexa, KS 66215
    Some nursing puppies, at 2, 4, and 6 weeks of age, given greatly exaggerated oral milbemycin oxime doses (9.6
    mg/kg = 19X) exhibited signs typified by tremors, vocalization and ataxia. These effects were all transient               Made in Canada.
                                                                                                                                                                                           ©2019 Ceva Animal Health, LLC. Lenexa, KS 66215
    and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies given the                       ANADA #200-629, Approved by FDA               MilbeGuard™ trademark is the property of Ceva Santé Animale S.A.

42 | Penn Veterinary Supply | March-April 2019                                                                      			                                                         1-800-233-0210 | www.pennvet.com
Clinical Pharmacology:
                                                                                                                           Peak fluralaner concentrations are achieved between 2 hours and 3 days following oral administration, and
                                                                                                                           the elimination half-life ranges between 9.3 to 16.2 days. Quantifiable drug concentrations can be measured
                                                                                                                           (lower than necessary for effectiveness) through 112 days. Due to reduced drug bioavailability in the fasted
      Flavored chews for dogs.
                                                                                                                           state, fluralaner should be administered with food.
      Caution:
                                                                                                                           Mode of Action:
      Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
                                                                                                                           Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives.
      Description:                                                                                                         Fluralaner is an inhibitor of the arthropod nervous system. The mode of action of fluralaner is the antagonism
      Each chew is formulated to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight.                              of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor).
      The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-         Effectiveness:
      yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino) ethyl]benzamide.                                                 Bravecto began to kill fleas within two hours after administration in a well-controlled laboratory study. In a
      Indications:                                                                                                         European laboratory study, Bravecto killed fleas and Ixodes ricinus ticks and reduced the numbers of live fleas
      Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides   and Ixodes ricinus ticks on dogs by >98% within 12 hours for 12 weeks. In a well-controlled laboratory study,
      felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor        Bravecto demonstrated 100% effectiveness against adult fleas 48 hours post-infestation for 12 weeks. In well-
      variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and              controlled laboratory studies, Bravecto demonstrated ≥93% effectiveness against Dermacentor variabilis, Ixodes
      puppies 6 months of age and older, and weighing 4.4 pounds or greater.                                               scapularis and Rhipicephalus sanguineus ticks 48 hours post-infestation for 12 weeks. Bravecto demonstrated
                                                                                                                           ≥90% effectiveness against Amblyomma americanum 72 hours post-infestation for 8 weeks, but failed to
      Bravecto is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations       demonstrate ≥90% effectiveness beyond 8 weeks.
      for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.
                                                                                                                           In a well-controlled U.S. field study, a single dose of Bravecto reduced fleas by ≥99.7% for 12 weeks. Dogs
      Dosage and Administration:                                                                                           with signs of flea allergy dermatitis showed improvement in erythema, alopecia, papules, scales, crusts, and
      Bravecto should be administered orally as a single dose every 12 weeks according to the Dosage Schedule              excoriation as a direct result of eliminating flea infestations.
      below to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight.
                                                                                                                           Palatability: In a well-controlled U.S. field study, which included 559 doses administered to 224 dogs, 80.7%
      Bravecto may be administered every 8 weeks in case of potential exposure to Amblyomma americanum ticks               of dogs voluntarily consumed Bravecto within 5 minutes, an additional 12.5% voluntarily consumed Bravecto
      (see Effectiveness).                                                                                                 within 5 minutes when offered with food, and 6.8% refused the dose or required forced administration.
      Bravecto should be administered with food.                                                                           Animal Safety:
      Dosage Schedule                                                                                                      Margin of Safety Study: In a margin of safety study, Bravecto was administered orally to 8- to 9-week-old
                                                                                                                           puppies at 1, 3, and 5X the maximum label dose of 56 mg/kg at three, 8-week intervals. The dogs in the
         Body Weight Ranges (lb)                Fluralaner Content (mg)                 Chews Administered
                                                                                                                           control group (0X) were untreated.
                    4.4 – 9.9                               112.5                                   One
                                                                                                                           There were no clinically-relevant, treatment-related effects on physical examinations, body weights, food
                   >9.9 – 22.0                               250                                    One                    consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross
                  >22.0 – 44.0                               500                                    One                    pathology, histopathology, or organ weights. Diarrhea, mucoid and bloody feces were the most common
                  >44.0 – 88.0                              1000                                    One                    observations in this study, occurring at a similar incidence in the treated and control groups. Five of the twelve
                                                                                                                           treated dogs that experienced one or more of these signs did so within 6 hours of the first dosing. One dog in
                 >88.0 – 123.0*                             1400                                    One
                                                                                                                           the 3X treatment group was observed to be dull, inappetant, with evidence of bloody diarrhea, vomiting, and
      *Dogs over 123.0 lb should be administered the appropriate combination of chews                                      weight loss beginning five days after the first treatment. One dog in the 1X treatment group vomited food 4
                                                                                                                           hours following the first treatment.
      Treatment with Bravecto may begin at any time of the year and can continue year round without interruption.
                                                                                                                           Reproductive Safety Study: Bravecto was administered orally to intact, reproductively-sound male and female
      Contraindications:                                                                                                   Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum label dose) on three to four occasions at
      There are no known contraindications for the use of the product.                                                     8-week intervals. The dogs in the control group (0X) were untreated.
      Warnings:                                                                                                            There were no clinically-relevant, treatment-related effects on the body weights, food consumption,
      Not for human use. Keep this and all drugs out of the reach of children. Keep the product in the original            reproductive performance, semen analysis, litter data, gross necropsy (adult dogs) or histopathology findings
      packaging until use, in order to prevent children from getting direct access to the product.                         (adult dogs and puppies). One adult treated dog suffered a seizure during the course of the study (46 days
      Do not eat, drink or smoke while handling the product. Wash hands thoroughly with soap and water                     after the second treatment). Abnormal salivation was observed on 17 occasions: in six treated dogs (11
      immediately after use of the product.                                                                                occasions) after dosing and four control dogs (6 occasions).
      Precautions:                                                                                                         The following abnormalities were noted in 7 pups from 2 of the 10 dams in only the treated group during
      Bravecto has not been shown to be effective for 12-weeks duration in puppies less than 6 months of                   gross necropsy examination: limb deformity (4 pups), enlarged heart (2 pups), enlarged spleen (3 pups), and
      age. Bravecto is not effective against Amblyomma americanum ticks beyond 8 weeks after dosing (see                   cleft palate (2 pups). During veterinary examination at Week 7, two pups from the control group had inguinal
      Effectiveness).                                                                                                      testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively.
                                                                                                                           No undescended testicles were observed at the time of necropsy (days 50 to 71).
      Adverse Reactions:
      In a well-controlled U.S. field study, which included 294 dogs (224 dogs were administered Bravecto every            In a well-controlled field study Bravecto was used concurrently with other medications, such as vaccines,
      12 weeks and 70 dogs were administered an oral active control every 4 weeks and were provided with a tick            anthelmintics, antibiotics, and steroids. No adverse reactions were observed from the concurrent use of
      collar); there were no serious adverse reactions. All potential adverse reactions were recorded in dogs treated      Bravecto with other medications.
      with Bravecto over a 182-day period and in dogs treated with the active control over an 84-day period. The           Storage Information:
      most frequently reported adverse reaction in dogs in the Bravecto and active control groups was vomiting.            Do not store above 86°F (30°C).
      Percentage of Dogs with Adverse Reactions in the Field Study                                                         How Supplied:
                                             Bravecto Group: Percentage                Active Control Group:               Bravecto is available in five strengths (112.5, 250, 500, 1000, and 1400 mg fluralaner per chew). Each chew
                                             of Dogs with the AR During               Percentage of Dogs with              is packaged individually into aluminum foil blister packs sealed with a peelable paper backed foil lid stock.
           Adverse Reaction (AR)                                                                                           Product may be packaged in 1, 2, or 4 chews per package.
                                                 the 182-Day Study                   the AR During the 84-Day
                                                    (n=224 dogs)                         Study (n=70 dogs)                 NADA 141-426, Approved by FDA
                    Vomiting                                 7.1                                    14.3                   Distributed by:
               Decreased Appetite                            6.7                                    0.0                    Intervet Inc (d/b/a Merck Animal Health)
                    Diarrhea                                 4.9                                    2.9                    Madison, NJ 07940
                    Lethargy                                 5.4                                    7.1                    Made in Austria
                   Polydipsia                                1.8                                    4.3                    Copyright © 2014 Intervet Inc, a subsidiary of Merck & Company Inc.
                   Flatulence                                1.3                                    0.0                    All rights reserved
                                                                                                                           154545 R1
      In a well-controlled laboratory dose confirmation study, one dog developed edema and hyperemia of the
      upper lips within one hour of receiving Bravecto. The edema improved progressively through the day and had
      resolved without medical intervention by the next morning.
      For technical assistance or to report a suspected adverse drug reaction, contact Merck Animal Health at
      1-800-224-5318. Additional information can be found at www.bravecto.com. For additional information about
      adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.
      fda.gov/AnimalVeterinary/SafetyHealth.

1-800-233-0210 | www.pennvet.com                                                                                                                                  Penn Veterinary Supply | March-April 2019 | 43
In addition, one dog experienced intermittent head tremors within 1.5 hours of
                                                                                                    administration of vaccines, an ear cleaning performed by the owner, and its first dose of
                                                                                                    CREDELIO. The head tremors resolved within 24 hours without treatment. The owner
                                                                                                    elected to withdraw the dog from the study.
                                                                                                    In an Australian field study, one dog with a history of seizures experienced seizure activity
                                                                                                    (tremors and glazed eyes) six days after receiving CREDELIO. The dog recovered without
                                                                                                    treatment and completed the study. In the U.S. field study, two dogs with a history of
                                                                                                    seizures received CREDELIO and experienced no seizures throughout the study.
                                                                                                    In three well-controlled European field studies and one U.S. laboratory study, seven dogs
                                                                                                    experienced episodes of vomiting and four dogs experienced episodes of diarrhea
                                                                                                    between 6 hours and 3 days after receiving CREDELIO.
                                                                                                    To report suspected adverse events, for technical assistance or to obtain a copy of the
                                                                                                    Safety Data Sheet (SDS), contact Elanco US, Inc. at 1-888-545-5973. For additional
                                                                                                    information about adverse drug experience reporting for animal drugs, contact FDA at
      Chewable Tablets                                                                              1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth.
      For oral use in dogs                                                                          Clinical Pharmacology:
                                                                                                    Following oral administration of 43 mg/kg (approximately 1X the maximum labeled dose),
      Caution:                                                                                      peak lotilaner concentrations were achieved between 6 hours and 3 days in dogs
      Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.   2 months of age and between 1 and 7 days in dogs 10 months of age. Dogs 2 months
      Description:                                                                                  of age had a shorter elimination half-life (average of 9.6 days) than at 10 months of age
      CREDELIO (lotilaner) is a beef-flavored, chewable tablet for oral administration to dogs      (average of 28.4 days). Due to reduced drug bioavailability in the fasted state, CREDELIO
      and puppies according to their weight. Each chewable tablet is formulated to provide a        must be administered with a meal or within 30 minutes after feeding.
      minimum lotilaner dosage of 9 mg/lb (20 mg/kg).                                               Mode of Action:
      Lotilaner has the chemical composition of 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-      Lotilaner is an ectoparasiticide belonging to the isoxazoline group. Lotilaner inhibits insect
      5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-    and acarine gamma-aminobutyric acid (GABA)-gated chloride channels. This inhibition
      2-thiophenecarboxamide.                                                                       blocks the transfer of chloride ions across cell membranes, which results in uncontrolled
      Indications:                                                                                  neuromuscular activity leading to death of insects and acarines. The selective toxicity of
      CREDELIO kills adult fleas and is indicated for the treatment of flea infestations            lotilaner between insects and acarines and mammals may be inferred by the differential
      (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma         sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.
      americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis    Effectiveness:
      (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs      In well-controlled European laboratory studies, CREDELIO began to kill fleas four hours
      and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.                     after administration or infestation, with greater than 99% of fleas killed within eight hours
      Dosage and Administration:                                                                    after administration or infestation for 35 days. In a well-controlled U.S. laboratory study,
      CREDELIO is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg).           CREDELIO demonstrated 100% effectiveness against adult fleas 12 hours after
      Dosage Schedule:                                                                              administration or infestation for 35 days.
                                        Lotilaner Per                    Chewable Tablets           In a 90-day well-controlled U.S. field study conducted in households with existing flea
             Body Weight                                                                            infestations of varying severity, the effectiveness of CREDELIO against fleas on Days 30,
                                   Chewable Tablet (mg)                    Administered
                                                                                                    60 and 90 compared to baseline was 99.5%,100% and 100%, respectively. Dogs with
            4.4 to 6.0 lbs                  56.25                               One
                                                                                                    signs of flea allergy dermatitis showed improvement in erythema, papules, scaling,
           6.1 to 12.0 lbs                  112.5                               One                 alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating fleas.
          12.1 to 25.0 lbs                   225                                One                 In well-controlled laboratory studies, CREDELIO demonstrated > 97% effectiveness
          25.1 to 50.0 lbs                   450                                One                 against Amblyomma americanum, Dermacentor variabilis, Ixodes scapularis and
         50.1 to 100.0 lbs                   900                                One                 Rhipicephalus sanguineus ticks 48 hours after administration or infestation for 30 days.
           Over 100.0 lbs        Administer the appropriate combination of chewable tablets         In a well-controlled European laboratory study, CREDELIO started killing Ixodes ricinus
                                                                                                    ticks within four hours after administration.
      CREDELIO must be administered with food (see Clinical Pharmacology).                          Palatability: In the U.S. field study, which included 567 doses administered to 198 dogs,
      Treatment with CREDELIO can begin at any time of the year and can continue year round         80.4% of dogs voluntarily consumed CREDELIO when offered by hand or in an empty
      without interruption.                                                                         bowl, an additional 13.6% consumed CREDELIO when offered with food, and 6.0%
      Contraindications:                                                                            required placement of the chewable tablet in the back of the dog’s mouth.
      There are no known contraindications for the use of CREDELIO.                                 Animal Safety:
      Warnings:                                                                                     In a margin of safety study, CREDELIO was administered orally to 24 (8 dogs/group)
      Not for human use. Keep this and all drugs out of the reach of children.                      8-week-old Beagle puppies at doses of 43 mg/kg, 129 mg/kg, and 215 mg/kg
                                                                                                    (approximately 1, 3, and 5X the maximum labeled dose, respectively) every 28 days for
      Precautions:
                                                                                                    eight consecutive doses. The 8 dogs in the control group (0X) were untreated. There were
      The safe use of CREDELIO in breeding, pregnant or lactating dogs has not been
                                                                                                    no clinically-relevant, treatment-related effects on clinical observations, physical and
      evaluated. Use with caution in dogs with a history of seizures (see Adverse Reactions).
                                                                                                    neurological examinations, body weights, food consumption, electrocardiograms, clinical
      Adverse Reactions:                                                                            pathology (hematology, clinical chemistries, coagulation profiles and urinalysis), gross
      In a well-controlled U.S. field study, which included 284 dogs (198 dogs treated with         pathology, histopathology, or organ weights. Blood concentrations of lotilaner confirmed
      CREDELIO and 86 dogs treated with an oral active control), there were no serious adverse      systemic exposure of all treated dogs, although the exposure was less than dose
      reactions.                                                                                    proportional at 5X.
      Over the 90-day study period, all observations of potential adverse reactions were            In a well-controlled field study, CREDELIO was used concurrently with other medications,
      recorded. Reactions that occurred at an incidence of 1% or greater are presented in the       such as vaccines, anthelmintics, antibiotics, steroids, NSAIDS, anesthetics, and
      following table.                                                                              antihistamines. No adverse reactions were observed from the concomitant use of
      Dogs with Adverse Reactions in the Field Study                                                CREDELIO with other medications.
          Adverse Reaction             CREDELIO Group:               Active Control Group:          Storage Information:
                (AR)                 Number (and Percent) of        Number (and Percent) of         Store at 15-25°C (59 -77°F), excursions permitted between 5 to 40°C (41 to 104°F).
                                     Dogs with the AR (n=198)       Dogs with the AR (n=86)         How Supplied:
             Weight Loss                     3 (1.5%)                       2 (2.3%)                CREDELIO is available in five chewable tablet sizes for use in dogs: 56.25, 112.5, 225,
                                                                                                    450, and 900 mg lotilaner. Each chewable tablet size is available in color-coded packages
         Elevated Blood Urea                  2 (1.0%)*                      0 (0.0%)               of 1 or 6 chewable tablets.
            Nitrogen (BUN)
                                                                                                    NADA #141-494, Approved by the FDA
                Polyuria                      2 (1.0%)*                      0 (0.0%)
                                                                                                    Manufactured for: Elanco US Inc
                Diarrhea                      2 (1.0%)                       2 (2.3%)                                       Greenfield, IN 46140 USA
      *Two geriatric dogs developed mildly elevated BUN (34 to 54 mg/dL; reference range:                                   Credelio.com
      6 to 31 mg/dL) during the study. One of these dogs also developed polyuria and a mildly       Credelio, Elanco and the diagonal bar logo are
      elevated potassium (6.5 mEq/L; reference range: 3.6 to 5.5 mEq/L) and phosphorous             trademarks of Eli Lilly and Company or its affiliates.
      (6.4 mg/dL; reference range: 2.5 to 6.0 mg/dL). The other dog also developed a mildly         Rev. date 11/2017
      elevated creatinine (1.7 to 2.0 mg/dL; reference range: 0.5 to 1.6 mg/dL) and weight loss.    PA209456X 12266                                                                         CRE1

44 | Penn Veterinary Supply | March-April 2019                                             			                                              1-800-233-0210 | www.pennvet.com
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Effectiveness: Prevention of the tissue larval stage of heartworm (Dirofilaria immitis) and the
                                                                                                                               elimination of the adult stage of hookworm (Ancylostoma caninum, Uncinaria stenocephala,
                                                                                                                               Anyclostoma braziliense), roundworm (Toxocara canis, Toxascaris leonina), and tapeworm
                                                                                                                               (Dipylidium caninum, Taenia pisiformis) infections in dogs was demonstrated in well-controlled
        Soft Chew                                                                                                              laboratory studies.
                                                                                                                               Palatability: In a field study of 132 dogs, IVERHART MAX Soft Chew was offered once monthly
       For oral use in dogs only.                                                                                              for 3 months. The dogs voluntarily consumed 86.3% of the doses from the owner’s hand or from
                                                                                                                               a bowl within 5 minutes, 13.0% accepted the dose when it was offered in food or administered
       Caution: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
                                                                                                                               by placing onto the back of the dog’s tongue (pilling), and 0.7% of the doses were unable to
       Description: IVERHART MAX® Soft Chew is a combination of three anthelmintics (ivermectin/pyrantel pamoate/              be administered.
       praziquantel). The soft chews are available in four sizes in color-coded packages for oral administration to dogs
                                                                                                                               Animal Safety: Studies with ivermectin indicate that certain dogs of the Collie breed
       according to their weight (see Dosage and Administration).
                                                                                                                               are more sensitive to the effects of ivermectin administered at elevated dose levels
       Indications: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm           (more than 16 times the target dose level of 6 mcg/ kg) than dogs of other breeds.
       larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms      At elevated doses, sensitive dogs showed more adverse reactions, which included
       (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma               mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability,
       braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).                                                    stupor, coma, and death. No signs of toxicity were seen at 10 times the
                                                                                                                               recommended dose (27.2 mcg/lb) in sensitive Collies. Data from these studies
       Dosage and Administration: IVERHART MAX Soft Chew should be administered orally at monhly intervals                     support the safety of ivermectin products in dogs, including Collies, when
       and the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/ lb), 5 mg of pyrantel             used at the label recommended dose.
       (as pamoate salt) per kg (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows:
                                                                                                                               Because ivermectin and praziquantel are approximately 30% more
           Dog Weight        Soft Chew         Soft Chew            Ivermectin      Pyrantel Pamoate       Praziquantel        bioavailable in the IVERHART MAX Soft Chew than in the ivermectin/
            Pounds           per Month            Size                Content           Content              Content           pyrantel pamoate/praziquantel tablets used in the following target
                                                                                                                               animal safety studies, the margin of safety is narrower than reported in
            6.0 to 12             1                Toy                 34 mcg              28.5 mg               28.5 mg       these studies. The potential for adverse reactions may be greater in individual
            12.1 to 25            1               Small                68 mcg                57 mg                57 mg        dogs administered IVERHART MAX Soft Chew than ivermectin/ pyrantel pamoate/
                                                                                                                               praziquantel tablets.
            25.1 to 50            1              Medium               136 mcg              114 mg                114 mg
                                                                                                                               In a target animal safety study using ivermectin/pyrantel pamoate/praziquantel tablets,
           50.1 to 100            1               Large               272 mcg              228 mg                228 mg        doses were administered to 8-week-old Beagle puppies at one, three, and five times
                                                                                                                               the maximum recommended dose of 12.5 mcg/kg ivermectin, 10.47 mg/ kg pyrantel,
       IVERHART MAX Soft Chew is recommended for dogs 8 weeks of age or older. For dogs over 100 lbs, use the                  and 10.47 mg/kg praziquantel. The dogs were treated every 30 days for 6 months.
       appropriate combination of these soft chews.                                                                            Vomiting within 6 hours of dosing and soft or watery feces within 24 hours of dosing
                                                                                                                               were observed. Other observations during the study were: ano-genital swelling, lethargy,
       Remove only one dose at a time from the packaging. Return the remaining soft chew(s) to their box to protect            head movements, shallow, audible or difficult breathing, and salivation. One dog in
       from light. The soft chew can be offered to the dog by hand or added, intact, to a small amount of dog food. Care       the 5X group had tremors and decreased activity. All of these signs were transient.
       should be taken to ensure that the dog consumes the complete dose. The treated dog should be observed for               No treatment was required. Histopathology showed testicular hypoplasia in the 3X
       a few minutes after administration to confirm that none of the dose has been lost or rejected. If it is suspected       and 5X groups (see Warnings).
       that any of the dose has been lost, redosing is recommended.
                                                                                                                               In a laboratory safety study using ivermectin/pyrantel pamoate/praziquantel tablets,
       IVERHART MAX Soft Chew should be given at monthly intervals during the period of the year when mosquitoes               12-week-old Beagle puppies receiving 3 and 5 times the recommended dose once
       (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within           weekly for 13 weeks demonstrated a dose-related decrease in testicular maturation
       a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month             compared to controls. In this study, all treated puppies had significantly higher
       (30 days) after the dog’s last exposure to mosquitoes.                                                                  cholesterol levels compared to untreated controls.
       When replacing another heartworm preventative product in a heartworm disease prevention program, the                    In a reproductive safety study, adult males were treated at 37.5 mcg/ kg ivermectin,
       first dose of IVERHART MAX Soft Chew must be given within a month (30 days) of the last dose of the former              31.4 mg/ kg pyrantel, and 31.4 mg/kg praziquantel every 14 days during two full
       medication. A heartworm test should be performed prior to switching heartworm preventative products.                    spermatogenic cycles (112 days). The quality of semen and reproductive health were
       If the interval between doses exceeds a month (30 days), the effectiveness of ivermectin can be reduced.                not affected by treatment. Treatment-related vomiting and soft feces were reported
       Therefore, for optimal performance, the soft chew must be given once a month on or about the same                       during this study.
       day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with                      In a study of the effectiveness of ivermectin/pyrantel pamoate/praziquantel tablets
       IVERHART MAX Soft Chew and the recommended dosing regimen will minimize the opportunity for the                         for the treatment of Toxocara canis, one 8.1 lb, 72-day-old puppy died 6 days
       development of adult heartworms.                                                                                        after administration of the label dose. This puppy and many other puppies
       Warnings:                                                                                                               in the study had high worm burdens and were reported to have diarrhea,
       For use in dogs only. Keep this and all drugs out of reach of children and pets. In safety studies with                 sometimes bloody, frequently before and after treatment. Dehydration and
       ivermectin/pyrantel pamoate/praziquantel tablets, testicular hypoplasia was observed in some dogs                       signs of anemia (pale mucous membranes) were the only abnormal gross necropsy
       receiving 3 and 5 times the maximum recommended dose monthly for 6 months (see Animal Safety).                          finding observed. No definitive cause was determined. In a 90-day field study
                                                                                                                               using ivermectin/pyrantel pamoate/praziquantel tablets, the most serious adverse
       In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may            reactions (lethargy, limpness, and salivation) were seen in dogs weighing less than
       contact a Poison Control Center for advice concerning cases of ingestion by humans.                                     10 lbs (see Precautions).
       Precautions: Use with caution in sick, debilitated, or underweight animals and dogs weighing less than 10 lbs           Storage Information: Store at 20°C to 25°C (68°F to 77°F), excursions permitted
       (see Animal Safety). The safe use of this drug has not been evaluated in pregnant or lactating bitches.                 between 15°C and 30°C (59°F to 86°F).
       All dogs should be tested for existing heartworm infection before starting treatment with IVERHART MAX Soft             How Supplied: IVERHART MAX Soft Chew is available in four dosage strengths
       Chew, which is not effective against adult Dirofilaria immitis. Infected dogs should be treated to remove adult         (see Dosage and Administration) for dogs of different weights. Each strength
       heartworms and microfilariae before initiating a heartworm prevention program.                                          comes in a package of 6 soft chews.
       While some microfilariae may be killed by the ivermectin in IVERHART MAX Soft Chew at the recommended dose
       level, IVERHART MAX Soft Chew is not effective for microfilariae clearance. A mild hypersensitivity-type reaction,      NADA 141-441, Approved by FDA.
       presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed
       in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
                                                                                                                               Manufactured by:
       Adverse Reactions: In a field study with IVERHART MAX Soft Chew, self-limiting adverse reactions, including
       vomiting, diarrhea, lethargy, difficulty swallowing, excessive salivation, increased water consumption, and             Virbac AH, Inc.
       coughing were reported. Self-limiting adverse reactions, including lethargy, limpness, salivation, shaking,             Fort Worth, TX 76137 USA
       diarrhea, decreased appetite, licking lips, and belching were reported between 20 minutes and 72 hours                  Phone: 1-800-338-3659
       following treatment in a field study with ivermectin/pyrantel pamoate/praziquantel tablets.                             IVERHART MAX is a registered trademark of Virbac Corporation.                              302143-03
       In field studies with ivermectin/pyrantel pamoate tablets, vomiting or diarrhea within 24 hours of dosing was                                                                                                           9/17
       rarely observed (1.1% of administered doses). The following adverse reactions have been reported in dogs
       following the use of ivermectin products: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia,
       staggering, convulsions, and hypersalivation.
       To report suspected adverse events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS),
       contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug
       experience reporting for animal drugs, contact the FDA at 1-888-FDA-VETS or online at http:// www.fda.gov/
       AnimalVeterinary/SafetyHealth.

                                                                                                                 © 2018 Virbac Corporation. All Rights Reserved. IVERHART MAX is a registered trademark of Virbac Corporation.
                                                                                                                    HEARTGARD and the Dog and Hand logo are registered trademarks of Merial, Inc. 3/18 17690 VPD286-18

46 | Penn Veterinary Supply | March-April 2019                                                                       			                                                            1-800-233-0210 | www.pennvet.com
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