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Programme Epidemiology and Public Health
Programmes
Epidemiology and Public Health
10 115 38 258
Research Professionals Research Publications
groups projects
Programme Directors
Jordi Alonso Caballero Jaume Marrugat de la Iglesia
RESEARCH GROUPS Research Group in Nursing Care
Silvia Esteban
Barcelona Research Infertility Group
Miguel Ángel Checa Social Epidemiology and Occupational Health
Consol Serra
Cardiovascular Epidemiology and Genetics
Roberto Elosua
Cardiovascular Risk and Nutrition ASSOCIATED GROUPS
Montserrat Fitó
Healthy Cities and Environmental Justice
Clinical and Molecular Epidemiology of Cancer Isabelle Anguelovski
Miquel Porta
Epidemiology and Evaluation
Maria Sala
Girona Heart Registry
Jaume Marrugat
Health Services
Jordi Alonso
2 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY
Epidemiology and Public Health Programme The Epidemiology and Public Health Programme (EPISAP) is formed by 10 research groups and has approximately 120 members. Our mission is to apply advanced epidemiologic methods for a better understanding of: a) the individual and societal burden of disease; b) major risk factors and underlying mechanisms; and c) the role of health services and interventions on health outcomes. Our research focuses on cancer, cardiovascular diseases, mental disorders, and on environmental and occupational exposures. We translate our research into public health and clinical practice and we innovate in the preventive and health care assessment fields. Outstanding scientific achievements in 2019 • Anguelovski I, Connolly J, Pearsall H, et al. Why green “climate gentrification” threatens poor and vulnerable populations. PNAS 2019; 116 (52): 26139-43. • Román M, Hofvind S, von Euler-Chelpin M, Castells X. Long-term risk of screen- detected and interval breast cancer after false-positive results at mammography screening: joint analysis of three national cohorts. Br J Cancer 2019; 120(2): 269-275. • Sayón-Orea C, et al. Effect of a Nutritional and Behavioral Intervention on Energy- Reduced Mediterranean Diet Adherence Among Patients with Metabolic Syndrome: Interim Analysis of the PREDIMED-Plus Randomized Clinical Trial. JAMA 2019; 322(15): 1486-99. EPISAP researchers directed 10 PhD theses defended in 2019, and obtained competitive funding for 6 national research projects, one H2020 project, one intensification grant, and 6 private contracts. Impact of our research in 2019 • Programme researchers have co-authored the European Guides for Screening and Diagnosis of Breast Cancer (EC Initiative on Breast Cancer). • Jordi Alonso received the Presidential Award from the International Society for Quality of Life Research (ISOQOL) for his contribution to the advancement of research into Health-Related Quality of Life. > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 3
Barcelona Research Infertility Group
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Miguel Ángel Checa Vizcaino
Mireia González Comadrán (Researcher)
91685@parcdesalutmar.cat Maria Prat Om (Researcher)
Ana Beatriz Robles Corchado (Researcher)
Biomedical care in fertility disorders has gained recognition as has the diagnosis and
treatment of a disease, infertility, where an essential biological function to achieve a life
plan is impaired. Taking this into consideration, since 1995, the diagnosis and treatment
of infertility has been included as a basic benefit within the Catalog of Services of the
National Health System (Royal Degree 63/1995, 20 January, health benefits under the
social security program).
The overall objective is to carry out research in a multidisciplinary group, and to
combine collective expertise to extend knowledge of the loss of fertility observed in
our society, as well as to offer preventive, diagnostic and therapeutic solutions that will
either minimize the impact of this disorder or successfully overcome it.
Epidemiological research aims to analyze various air pollutants and environmental
factors and assess their impact on reproductive outcomes, including sperm quality,
which may lead to guidelines for the prevention or reduction of human exposure to
environmental pollutants.
Clinical research in human model will allow us to assess strategies that may potentially
improve reproductive functions and thereby increase live birth rate when ART are
required.
4 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY
Epidemiology and Public Health Barcelona Research Infertility Group
Evidence Based Medicine research: We collaborate with the Cochrane Gynecology and
Fertility group evaluating the evidence in reproductive medicine in international studies.
We aim to develop translational recommendations for best clinic practice.
Main Publications
• Bellver J, Bosch E, Espinós JJ, Fabregues F, Fontes J, García-Velasco J, Llácer J,
Requena A, Checa MA; Spanish Infertility SWOT Group (SISG). Second-generation
preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT
analysis. Reprod Biomed Online 2019; 39(6): 905-915. IF 2.930. Q1.
• Moreno-Sepúlveda J, Checa MA. Risk of adverse perinatal outcomes after oocyte
donation: a systematic review and meta-analysis. J Assist Reprod Gen 2019; 36(10):
2017-2037. IF 2.820. Q1.
• Mañé L, Flores-Le Roux JA, Pedro-Botet J, Gortázar L, Chillarón JJ, Llauradó G, Payà A,
Benaiges D. Is fasting plasma glucose in early pregnancy a better predictor of adverse
obstetric outcomes than glycated haemoglobin? Eur J Obstet Gynecol Reprod Biol
2019; 234: 79-84. IF 2.024. Q3.
• Mañé L, Flores-Le Roux JA, Benaiges D, Chillarón JJ, Prados M, Pedro-Botet J,
Llauradó G, Gortázar L, Payà A. Impact of overt diabetes diagnosed in pregnancy in a
multi-ethnic cohort in Spain. Gynecol Endocrinol 2019; 35(4): 332-336. IF 1.406. Q4.
See all Publications
Participation in Research Networks
• CIBER Cancer
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB16/12/00244)
- Period: from 2017 to 2019
- Principal investigator: Bigas Salvans, Anna
Clinical Trials Signed in 2019
• Ensayo clínico fase III, aleatorizado, abierto, multicéntrico y de grupos paralelos para la
detección, en segundo trimestre del embarazo, de los falsos positivos del cribado de
preeclampsia de primer trimestre (StopPRE)
- Sponsor: Fundació Institut Recerca Hospital Vall d’Hebron
- Budget: No economic compensation
- Principal investigator: Prat Om, Maria
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 5
Epidemiology and Public Health Barcelona Research Infertility Group
Theses
• Lattes K. Resultados reproductivos en mujeres sometidas a ciclos de fecundación
in vitro en fresco versus ciclos segmentados (freeze-all). Universitat Autònoma de
Barcelona
- Directors: Checa Vizcaíno, Miguel Ángel; Vassena, R
- Date of defense: 11/07/2019
• Moreno JA. Impacto de los tratamientos de reproducción asistida sobre los resultados
maternos y perinatales. Universitat Autònoma de Barcelona
- Directors: Checa Vizcaíno, Miguel Ángel; Moreno, JA
- Date of defense: 19/09/2019
• Vidal M. Resultats perinatals en tècniques de reproducció assistida. Estudi de la
cohort catalana. Universitat Autònoma de Barcelona
- Directors: Checa Vizcaíno, Miguel Ángel; Carreras Collado, Ramón
- Date of defense: 23/05/2019
Outreach
Conferences, Seminars and Courses
• Miguel Ángel Checa, organizer. Ist International Symposium on Diet, Lifestyle and
Fertility. PRBB. Barcelona, 29 November 2019.
6 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY
Cardiovascular Epidemiology and Genetics
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Roberto Elosua Llanos
Albert Clarà Velasco (Researcher)
relosua@imim.es María Grau Magaña (Researcher)
Alina Velescu (Researcher)
Maria del Mar Vila Muñoz (PhD Student)
Marta Cabañero Marimon (Technician)
Alba Fernández Sanlés (Technician)
Isaac Subirana Cachinero (Technician)
Esmeralda Gómez Pires (Research Assistant)
The group focuses on the study of the epidemiology and genetic basis of cardiovascular
disorders and their risk factors. The group participates in international consortia using
genome-wide and exome sequencing approaches to identify common and rare genetic
variants associated with cardiovascular traits. We are also interested in the study of
epigenetic signatures, mainly DNA methylation, related to these diseases.
The research team comprises a multidisciplinary group of epidemiologists, biologists,
biochemists, clinicians and biostatisticians who work together to tackle these topics.
We use this knowledge to identify new mechanisms and new predictive biomarkers of
cardiovascular risk, and to define instrumental variables to assess the causal relationship
between a biomarker and a cardiovascular phenotype.
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 7
Epidemiology and Public Health Cardiovascular Epidemiology and Genetics
The members of the group also participate in the REGICOR (REgistre GIroní del
COR) study to determine the burden of cardiovascular disease and its risk factors at
the population level, and to develop and improve cardiovascular risk functions. We
are also actively exploring the dose-response relationship between physical activity
and cardiovascular disease, and the mechanisms by which physical activity reduces
cardiovascular risk. Finally, we are also exploring, developing and evaluating new
approaches to improve cardiovascular prevention by using new information-technology
tools.
Main Publications
• Grau M. Lipid parameter thresholds: The debate continues. Eur J Prev Cardiol
2019;26(14):1493–1495. IF 5.64. Q1.
• Subirana I, Fernández Avilés F, Elosua R, Lidón RM, García-Dorado D, Marrugat
J; investigadores del estudio ATHOS. Interhospital Variability in Acute Coronary
Syndrome Management in the ATHOS Study. Rev Esp Cardiol (Engl Ed) 2019; 72:
691-693. IF 5.126. Q1.
• Sayols-Baixeras S, Fernández-Sanlés A, Prats-Uribe A, Subirana I, Plusquin M, Künzli
N, Marrugat J, Basagaña X, Elosua R. Association between long-term air pollution
exposure and DNA methylation: The REGICOR study. Environ Res 2019; 176:
108550. IF 5.026. Q1.
• De Gonzalo-Calvo D, Elosua R, Vea A, Subirana I, Sayols-Baixeras S, Marrugat J,
Llorente-Cortés V. Soluble low-density lipoprotein receptor-related protein 1 as a
biomarker of coronary risk: Predictive capacity and association with clinical events.
Atherosclerosis 2019; 287: 93-99. IF 4.255. Q1.
• Fa-Binefa M, Clará A, Pérez-Fernández S, Grau M, Dégano IR, Martí-Lluch R, Ramos R,
Marrugat J, Elosua R. Early smoking-onset age and risk of cardiovascular disease and
mortality. Prev Med 2019; 124: 17-22. IF 3.499. Q1.
See all Publications
Ongoing Research Projects
• Eficacia de una aplicación móvil para la prevención de las enfermedades
cardiovasculares a través del empoderamiento individual y comunitario
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI17/00250)
- Period: from 2018 to 2020
- Principal investigator: Grau Magaña, María
8 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY
Epidemiology and Public Health Cardiovascular Epidemiology and Genetics
• Seguiment de la cohort poblacional de l’estudi REGICOR: tendències en la incidència
de malaltia cardiovascular, en la prevalença de factors de risc, identificació de nous
mecanismes i biomarcadors predictius, i avaluació d’estratègies de prevenció
- Financing institution: Departament de Salut, Generalitat de Catalunya
(SLT002/16/00088)
- Period: from 2017 to 2019
- Principal investigator: Elosua Llanos, Roberto
See all Projects
Participation in Research Networks
• CIBER Enfermedades Cardiovasculares
- Fondo de Investigación Sanitaria. ISCIII (CB16/11/00246)
- Principal investigators: Elosua Llanos, Roberto; Clará Velasco, Albert; Velescu, Alina
• CIBER Epidemiología y Salud Pública
- Fondo de Investigación Sanitaria. ISCIII (CB06/02/0029)
- Principal investigator: Grau Magaña, María
Clinical Trials Signed in 2019
• Preparación e implementación del protocolo del estudio “Ensayo clínico abierto,
no aleatorizado en dos conglomerados constituidos por dos poblaciones urbanas
distintas, compartivo de una intervención preventiva con un grupo control
sin intervención sobre el control de factores de riesgo cardiovascular. Healthy
Communities”.
- Fundació Privada SHE
- Principal investigator: Elosua Llanos, Roberto
Theses
• Sayols-Baixeras S. DNA methylation and its relationship with lifestyle, environmental
and cardiovascular risk factors. Universitat Pompeu Fabra
- Director: Elosua Llanos, Roberto; Lluís-Ganella, C
- Date of defense: 18/02/2019
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 9
Epidemiology and Public Health Cardiovascular Epidemiology and Genetics
• Vázquez Oliva, G. El síndrome coronario agudo: tendencias en la magnitud del
problema, en el manejo hospitalario y en la aparición de complicaciones en un estudio
de base poblacional y mejoras en las estrategias de prevención individual. Universitat
de Girona
- Director: Elosua Llanos, Roberto
- Date of defense: 08/02/2019
Awards
• María Grau Magaña. Prize for the best publication in primary care. Col·legi Oficial de
Metges de Barcelona. 27/11/2019.
• Roberto Elosua Llanos. Second prize for the most cited long-term article in Revista
Española de Cardiología 2019. Sociedad Española de Cardiología (SEC). 18/10/2019.
Appointments
• Roberto Elosua Llanos. Professor of Medicine. Universitat de Vic-Universitat Central
de Catalunya. Date: 12/07/2019.
Outreach
Dissemination to Society and Initiatives of Citizen Participation
• Roberto Elosua Llanos, María Grau Magaña, Alba Fernández Sanlés. Workshop
Mesure your cardiovascular health. Open Day of the Parc de Recerca Biomèdica de
Barcelona (PRBB), 5 October 2019.
• Roberto Elosua Llanos. Excursion through the different stages of a research project.
Students of the Secretary Coloma Institute visit the Laboratory of Cardiovascular
Epidemiology and Genetics Group. ACCÉS Project (Bringing Science Closer to
Secondary Schools) included in the Escolab Project. Barcelona Science Programme of
the Institute of Culture. 21 March 2019.
10 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYCardiovascular Risk and Nutrition
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Montserrat Fitó Colomer
David Benaiges Boix (Researcher)
mfito@imim.es Olga Castañer Niño (Researcher)
Juan José Chillarón Jordán (Researcher)
Juana Antonia Flores Le Roux (Researcher)
Albert Goday Arno (Researcher)
Camille Lassale (Researcher)
Gemma Llauradó Cabot (Researcher)
Helmut Schröder (Researcher)
Montserrat Villatoro Moreno (Researcher)
Albert Sanllorente Melenchón (PhD Student)
Gemma Blanchart Cuella (Technician)
Daniel Muñoz Aguayo (Technician)
Ana Isabel Quindós Sendino (Technician)
María Dolores Zomeño Fajardo (Technician)
Anna Maria Blasco Lapuente (Research Assistant)
The Mediterranean diet, its foods and the interaction of its nutrients, have healthy
effects on morbidity and mortality related to chronic degenerative diseases, such as
cardiovascular disease.
In this context, the main objective of our research is to determine the benefit of a
healthy diet pattern and some characteristic foods (including olive oil and wine) on
different cardiovascular risk factors. We also focus on lifestyle habits including diet and
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 11Epidemiology and Public Health Cardiovascular Risk and Nutrition
physical activity on obesity (both in children and adults), diabetes, and cardiovascular
diseases. The health effects of bariatric surgery on cardiovascular risk factors and
cardiometabolic diseases, are also among our aims.
Based on the knowledge of underlying mechanisms beyond the diet benefits, progress
is being made in research of the classical and emerging risk factors for cardiovascular
and neurodegenerative diseases. One of our main research lines is focused on HDL and
ApoB-containing particles.
Firstly, it is becoming increasingly more accepted that the biological functions of HDL
are more indicative of the cardioprotective role of these particles than the quantity
of HDL cholesterol. Reduced values of the most relevant HDL function (its ability to
pick up cholesterol from peripheral cells, the cholesterol efflux) have been shown to
be linked to a high risk of sub-clinical atherosclerosis and high incidence of coronary
events. Our group was the first to report the protective effect of a healthy dietary
pattern (a Mediterranean Diet enriched with virgin olive oil) and real-life doses of virgin
olive oil on HDL functions.
Secondly, we are also interested in the residual risk factor linked to the atherogenicity of
ApopB-containing particles such as LDL and triglyceride-rich lipoproteins.
Main Publications
• Hernáez A, Sanllorente A, Castañer O, Martínez-González MÁ, Ros E, Pintó X,
Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez ÁM, Serra-Majem L, Fiol M,
Lapetra J, Gómez-Gracia E, de la Torre R, Lamuela-Raventós RM, Fitó. M. Increased
Consumption of Virgin Olive Oil, Nuts, Legumes, Whole Grains, and Fish Promotes
HDL Functions in Humans. Mol Nutr Food Res 2019; 63(6): e1800847. IF 4.653. D1.
• Cárdenas-Fuentes G, Subirana I, Martínez-González MA, Salas-Salvadó J, Corella
D, Estruch R, Fitó M, Muñoz-Bravo C, Fiol M, Lapetra J, Aros F, Serra-Majem L, Tur
JA, Pinto X, Ros E, Coltell O, Díaz-López A, Ruiz-Canela M, Schröder H. Multiple
approaches to associations of physical activity and adherence to the Mediterranean
diet with all-cause mortality in older adults: the PREvención con DIeta MEDiterránea
study. Eur J Nutr 2019; 58(4): 1569-1578. IF 4.449. Q1.
• Farràs M, Arranz S, Carrión S, Subirana I, Muñoz D, Blanchart G, Kool M, Solà R,
Motilva MJ, Escolà-Gil JC, Rubió L, Fernández-Castillejo S, Pedret A, Estruch R, Covas
MI, Fitó M, Hernáez A, Castañer O. A Functional Virgin Olive Oil Enriched with Olive
Oil and Thyme Phenolic Compounds Improves the Expression of Cholesterol Efflux-
Related Genes: A Randomized, Crossover, Controlled Trial. Nutrients 2019; 11(8):
E1732. IF 4.171. Q1.
• Julià H, Benaiges D, Mollà P, Pedro-Botet J, Villatoro M, Fontané L, Ramon JM, Climent
E, Flores Le Roux JA, Goday A. Changes in Thyroid Replacement Therapy after Bariatric
Surgery: Differences between Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic
Sleeve Gastrectomy. Obes Surg 2019; 29(8): 2593-2599. IF 3.603. Q1.
See all Publications
12 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Cardiovascular Risk and Nutrition
Ongoing Research Projects
• Integridad neurovascular y desarrollo de demencia: Efecto neuroprotector de las
lipoproteínas de alta densidad y marcadores asociados
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI17/00214)
- Period: from 2018 to 2020
- Principal investigator: Castañer Niño, Olga
• Efecto de intervenciones sobre el estilo de vida, basadas en dieta y actividad física,
sobre la dislipemia aterogénica en pacientes con síndrome metabólico
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI18/00020)
- Period: from 2019 to 2021
- Principal investigator: Fitó Colomer, Montserrat
• Ensayo clínico controlado con grupos paralelos para evaluar el efecto in vivo del pan
EliasBoulanger de larga fermentación (pan EBLF) comparado con pan industrial de
corta fermentación (pan CF) en pacientes con síndrome metabólico
- Financing institution: Agencia Estatal de Investigación. Convocatoria RETO-
Colaboración
- Period: from 2018 to 2020
- Principal investigator: Fitó Colomer, Montserrat
• Microbiota intestinal como mecanismo implicado en el efecto “halo” en familiares de
pacientes con obesidad grave
- Financing institution: Societat Catalana d’Endocrinologia i Nutrició
- Period: from 2019 to 2020
- Principal investigator: Goday Arno, Albert
See all Projects
Participation in Research Networks
• CIBEROBN: Fisiopatología de la Obesidad y Nutrición
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB06/03/0028)
- Period: from 2013
- Principal investigator: Fitó Colomer, Montserrat
• CIBERESP: Fisiopatología de Salud Pública y Epidemiología
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB06/03/0028)
- Period: from 2013
- Principal investigator: Schröder, Helmut
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 13Epidemiology and Public Health Cardiovascular Risk and Nutrition
Theses
• Soria-Florido MT. Role and predictive value of the HDL function for cardiovascular
disease in a high risk population. HDL function-linked markers and mechanisms.
Universitat de Barcelona
- Director: Fitó Colomer, Montserrat
- Date of defense: 11/01/2019
• Parri A. Influencia de la educación nutricional, hábitos de estilo de vida obesogénicos
y predictores de pérdida de peso en pacientes con obesidad grave incluidos en un
programa de cirugía bariátrica. Universitat de Barcelona
- Director: Goday Arno, Albert
- Date of defense: 13/11/2019
• Cárdenas-Fuentes G. Association of physical activity with cardiovascular risk factors
and all-cause mortality in older Spanish individuals. Universitat Pompeu Fabra
- Director: Schröder, Helmut
- Date of defense: 24/04/2019
Awards
• PREDIMEDPlus Team (IP: Montserrat Fitó Colomer). Second prize “NAOS Strategy
Award to all PREDIMED-PLUS” Team within the Health Sector. Agencia Española de
Seguridad Alimentaria y Nutrición. 2019.
Outreach
Conferences, Seminars and Courses
• Montserrat Fitó Colomer. Session group: Gastronomy: great driver of fish
consumption. Forum pesca dieta mediterránea. Organització de Productors Pesquers
de Sant Carles de la Ràpita and Confraria de Pescadors Verge del Carme de Sant
Carles de la Ràpita, in collaboration with Ajuntament de Sant Carles de la Ràpita and
Fundació Dieta Mediterrània. Sant Carles de la Ràpita, 4-5 April 2019.
Dissemination to Society and Initiatives of Citizen Participation
• Montserrat Fitó Colomer. Health benefits of the Mediterranean diet: Myth or reality?
Closing speech of the Curs de Nutrició del programa Bojos per la Ciència. Hospital
Universitari de Bellvitge, 30 November 2019.
• Workshop on Mediterranean Diet and Cardiovascular Risk. CARIN Group. Open Day
of the Parc de Recerca Biomèdica de Barcelona (PRBB), 5 October 2019.
14 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Cardiovascular Risk and Nutrition • Montse Fitó, Dolors Zomeño, Alejandra Pérez, Olga Castañer, Dani Muñoz, Helmut Schröder. Open seminar to the altruistic public of the call regarding the current project of “La Marató TV3”. 19 March and 21 May 2019. • Nutritional session and the Nutriscore for the PRBB Staff. Health week at the Parc de Recerca Biomèdica de Barcelona (PRBB). 8-17 November 2019. • Montse Fitó, Dani Muñoz, Albert Sanllorente. Excursion through the different stages of a research project. Students of the Secretary Coloma Institute visit the Laboratory of Cardiovascular Risk and Nutrition Group. ACCÉS Project (Bringing Science Closer to Secondary Schools) included in the Escolab Project. Barcelona Science Programme of the Institute of Culture. 21 March 2019. • Theatre play organized by the CARIN Group for nutritional advice and lifestyle for the PREDIMEDplus Study participants. October 2019. > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 15
Clinical and Molecular Epidemiology
of Cancer
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Miquel Porta Serra
Immaculada Collet Diví (Technician)
mporta@imim.es Magda Gasull Panadès (Technician)
José Antonio Pumarega Rodríguez (Technician)
Yolanda Rovira Pons (Research Assistant)
We conduct integrative scientific research on human pancreatic cancer at all causal
and mechanistic levels, from genomics to clinical medicine to the social and physical
environment. Our aim is to achieve an optimal integration of professional cultures,
scientific knowledge, methodologies and techniques from epidemiology and public
health, clinical medicine and the biological sciences. We are a team that has worked
across disciplines for more than three decades, one of the pioneer groups in Europe on
clinical and molecular epidemiology. Cancer is a complex set of processes that result
from the accumulation of genetic, epigenetic and other alterations during the lifecourse.
Thus, integrative studies on the causes of cancer are a natural meeting point between
molecular biology and epidemiology. We are also a world-recognized research group on
the biomonitoring of internal body concentrations of environmental chemical agents
(‘internal contamination’) in representative samples of the general population.
16 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Clinical and Molecular Epidemiology of Cancer
Main Publications
• Camargo J, Pumarega J, Alguacil J, Sanz-Gallén P, Gasull M, Delclos GL, Amaral
AF, Porta M. Toenail concentrations of trace elements and occupational history in
pancreatic cancer. Environ Int 2019; 127: 216-225. IF 7.943. Q1.
• Gasull M, Pumarega J, Kiviranta H, Rantakokko P, Raaschou-Nielsen O, Bergdahl
IA, et al. Methodological issues in a prospective study on plasma concentrations
of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.
Environ Res 2019; 169: 417-433. IF 5.026. Q1.
• Porta M, Vandenberg LN. There are good clinical, scientific, and social reasons to
strengthen links between biomedical and environmental research. J Clin Epidemiol
2019; 111: 124-126. IF 4.65. Q1.
• Llorente C, Revuelta G, Carrió M, Porta M. Scientists’ opinions and attitudes towards
citizens’ understanding of science and their role in public engagement activities. PLoS
One 2019; 14(11): e0224262. IF 2.776. Q2.
• Gómez-Tomás Á, Pumarega J, Alguacil J, Amaral AFS, Malats N, Pallarès N, Gasull
M, Porta M; PANKRAS II Study Group. Concentrations of trace elements and KRAS
mutations in pancreatic ductal adenocarcinoma. Environ Mol Mutagen 2019; 60(8):
693-703. IF 2.528. Q2.
See all Publications
Ongoing Research Projects
• Influencia de las concentraciones de compuestos tóxicos persistentes sobre la
mortalidad, la incidencia de trastornos crónicos y la expresión de miARN en población
general
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI17/00088)
- Period: from 2017 to 2020
- Principal investigator: Porta Serra, Miquel
See all Projects
Participation in Research Networks
• CIBERESP: Epidemiología y salud pública
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB06/02/0034)
- Period: from 2006 to 2019
- Principal investigator: Porta Serra, Miquel
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 17Epidemiology and Public Health Clinical and Molecular Epidemiology of Cancer
• NCD Risk Factor Collaboration (NCD-RisC)
- Financing institution: NCD Risk Factor Collaboration (NCD-RisC) (13078)
- Period: from 2014
- Principal investigator: Porta Serra, Miquel
• European Prospective Investigation into Cancer and Nutrition (EPIC)
- Financing institution: IARC (13080)
- Period: from 2014
- Principal investigator: Porta Serra, Miquel
• Pancreatic Cancer Case-Control Consortium (PanC4)
- Financing institution: Pancreatic Cancer Case-Control Consortium (PanC4)
(13079)
- Period: from 2014
- Principal investigator: Porta Serra, Miquel
Theses
• Gasull M. Anàlisi de la contaminació de la població general per compostos tòxics
persistents i d’alguns dels seus efectes adversos per a la salut. Universitat Autònoma
de Barcelona
- Director: Porta Serra, Miquel
- Date of defense: 27/11/2019
Appointments
• Miquel Porta. Adjunct Professor, Center for the Investigation of Environmental
Hazards, Department of Pediatrics, New York University (NYU). December 2019.
Outreach
Conferences, Seminars and Courses
• Miquel Porta Serra. Workshop “Anthropocene and Public Health”. Max Planck Institute
for the History of Science. Berlin, October 2019.
• Miquel Porta Serra. CEHS Special Cancer and Environmental Epidemiology Seminar.
University of North Carolina at Chapel Hill. North Carolina, October 2019.
• Miquel Porta Serra. Methodological Issues in a Prospective Study on Organic
Pollutants and Pancreatic Cancer Risk. University of North Carolina at Chapel Hill.
North Carolina, October 2019.
18 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Clinical and Molecular Epidemiology of Cancer • Miquel Porta Serra. Methodological Issues in a Prospective Study on Organic Pollutants and Pancreatic Cancer Risk. Harvard University, October 2019. • Miquel Porta Serra. Internal Contamination of Human Bodies from Toxic Chemicals: What are the Relevant Frames of Thought? Langone Health, Division of Environmental Pediatrics. October 2019. • Miquel Porta Serra. A prospective European Study on Persistent Pollutants and Pancreatic Cancer Risk. Participation in the Environmental Public Health seminar. Columbia University, NYC. November 2019. Dissemination to Society and Initiatives of Citizen Participation • Miquel Porta Serra. Epidemiology seminar on Biomedical Writing. Universidad de Santiago de Compostela. January 2019. • Miquel Porta Serra. Nuestra contaminación interna por residuos de plásticos y otros compuestos ambientales. Ateneu de Maó, November 2019. • Miquel Porta Serra. Aliments Salud i Tòxics. Universitat de Vic. December 2019. • Miquel Porta Serra, Magda Gasull Panadès, Jose Pumarega Rodríguez. Collaboration with the REZERO campaign “Salut de plàstic”. 2019 > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 19
Epidemiology and Evaluation
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Maria Sala Serra
Andrea Buron Pust (Researcher)
92601@parcdesalutmar.cat Xavier Castells Oliveres (Researcher)
Mercè Comas Serrano (Researcher)
Francesc Cots Reguant (Researcher)
Laia Domingo Torrell (Researcer)
Francesc Assís Macià Guilà (Researcher)
Margarita Posso Rivera (Researcher)
Anna Renom Guiteras (Researcher)
Marta Román Expósito (Researcher)
Roser Terradas Robledo (Researcher)
Cristina Hernández Rodríguez (Technician)
Anna Jansana Riera (Technician)
Diego Juárez Rodríguez (Technician)
Javier Louro Aldamiz-Echevarría (Technician)
Pietro Chiarello (Research Assistant)
Irene Fernández García (Research Assistant)
Priscila Giraldo Matamoros (Research Assistant)
Esther Martínez Amor (Research Assistant)
This is a group with multidisciplinary training (epidemiology, health economy, statistics
and nursing), which has carried out research activity in the field of health services
research (HSR), specifically in the evaluation of the effectiveness and costs of health
services and interventions; the evaluation of the needs and use of health services; and
20 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Epidemiology and Evaluation
the development of instruments for HSR. Current research areas focus mainly on the
evaluation of the health care process in cancer patients, focusing on breast and colon
cancer screening, also using real world data, and the impact of the process on survival,
specifically in the study of cancer screening personalization and on health care of long-
term survivors.
The group is recognized by AGAUR (Agència de Gestió d’Ajuts Universitaris i de
Recerca, Generalitat de Catalunya) as a research group in epidemiology and evaluation
(2017 SGR 213; from 2018 to 2021; Principal investigator: Xavier Castells Oliveres).
Main Publications
• Burón A, Román M, Augé JM, Macià F, Grau J, Sala M, Louro J, Martínez-Alonso M,
Álvarez C, Andreu M, Bessa X, Zaffalon D, Castells A, Pellisé M, Aldea M, Rivero L,
Hernández C, Torá-Rocamora I, Castells X. Changes in FIT values below the threshold
of positivity and short-term risk of advanced colorectal neoplasia: Results from a
population-based cancer screening program. Eur J Cancer 2019; 107: 53-59. IF 6.68.
Q1.
• Louro J, Posso M, Hilton Boon M, Román M, Domingo L, Castells X, Sala M. A
systematic review and quality assessment of individualised breast cancer risk
prediction models. Br J Cancer 2019; 121(1): 76-85. IF 5.416. Q1.
• Román M, Hofvind S, von Euler-Chelpin M, Castells X. Long-term risk of screen-
detected and interval breast cancer after false-positive results at mammography
screening: joint analysis of three national cohorts. Br J Cancer 2019; 120(2): 269-275.
IF 5.416. Q1.
• Jansana A, Posso M, Guerrero I, Prados-Torres A, Del Cura M, Castells X, Sala M.
Health care services use among long-term breast cancer survivors: a systematic
review. J Cancer Surviv 2019; 13(3): 477-493. IF 3.585. Q2.
• Román M, Sala M, Baré M, Posso M, Vidal C, Louro J, Sánchez M, Peñalva L, Castells
X, BELE study group. Changes in mammographic density over time and the risk of
breast cancer: An observational cohort study. Breast 2019; 46: 108-115. IF 3.494.
Q1.
See all Publications
Ongoing Research Projects
• Estimating individual breast cancer risk according to women’s known risk factors for
personalised population-based mammographic screening
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI17/00047)
- Period: from 2018 to 2020
- Principal investigator: Román Expósito, Marta
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 21Epidemiology and Public Health Epidemiology and Evaluation
• Evaluation of the sequential pattern of faecal occult blood and its relationship
with the risk of colorectal neoplasia: towards the optimization of population-based
colorectal cancer screening programs
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/00239)
- Period: from 2017 to 2019
- Principal investigator: Burón Pust, Andrea
• Comorbidity and patterns of heald care use in women who have survived a breast
cancer for at least five years
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI16/00244)
- Period: from 2017 to 2019
- Principal investigator: Sala Serra, Maria
• Benign breast disease, breast density and association with breast cancer in a
population-based breast cancer screening program
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI15/00098)
- Period: from 2016 to 2020
- Principal investigator: Castells Oliveres, Xavier
• Randomized, comparison of risk-stratified versus standard breast cancer screening In
European women aged 40-74
- Financing institution: European Commission (Topic D: SC1-PM-10-2017)
- Period: from 2018 to 2025
- Principal investigators: Castells Oliveres, Xavier; Román Expósito, Marta
See all Projects
Participation in Research Networks
• Research network on health services in chronical diseases – REDISSEC (Red de
Investigación en Servicios de Salud en Enfermedades Crónicas)
- Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS (RD12/0001/0015)
- Period: from 2017 to 2021
- Principal investigator: Sala Serra, Maria
• Breast Cancer Screening Guidelines Development Group
- Financing institution: European Commission Initiative on Breast Cancer (ECIB)
- Period: from 2015 to 2020
- Principal investigator: Castells Oliveres, Xavier
22 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Epidemiology and Evaluation Awards • Javier Louro García-Aldámiz. XV Research Grant “Alicia Llacer” for young researchers. Sociedad Española de Epidemiología, SEE. 2019 • Anna Jansana. Award for research on breast cancer survivors to the work “Use of health services and comorbidities in long-term breast cancer survivors: protocol of the SURBCAN project”. The 10 best oral communications in the XXXIX Congress of the Spanish Society of Family and Community Medicine (semFYC). Málaga, 8-10 May 2019. Appointments • Andrea Burón Pust. Member of the Steering Committee. International Cancer Screening Network, (ICSN). 2019 Outreach Conferences, Seminars and Courses Events • Francesc Macià Guilà. Event organiser and coordinator of the Scientific Committee. XXII Workshop on Breast Cancer: What about after cancer? Chronicity and quality of life of patients after breast cancer. Hospital del Mar, Barcelona, 22 March 2019. • Maria Sala. Member of the Scientific and Organisational Committee. VII REDISSEC Workshop: Towards research with an impact on society. REDISSEC (Research network on health services in chronical diseases). Barcelona, 7 November 2019. • Andrea Burón, Xavier Castells, Francesc Macià. Speakers and members of the Scientific Committee. Workshop 10 years preventing colon and rectal cancer in Barcelona. Colon and Rectal Cancer Early Detection Program, Health Department, Generalitat de Catalunya. Barcelona, 13 December 2019. Lectures • Xavier Castells. Critical reflections: Is it time to propose changes in the Programs by establishing more personalized approaches? Breast image update workshop. Sociedad Española de Diagnóstico por Imagen de la Mama (SEDIM). Madrid, February 2019. • Maria Sala. Projects to improve the quality of healthcare in the Parc de Salut Mar Quality Programme: involve and evaluate. Innovation in process improvement: challenges and opportunities. ITEMAS Meeting. Parc Taulí, Sabadell, 11 Desember 2019. > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 23
Epidemiology and Public Health Epidemiology and Evaluation • Andrea Burón. Where are we? Workshop 10 years preventing colon and rectal cancer in Barcelona. Colon and Rectal Cancer Early Detection Program, Health Department, Generalitat de Catalunya. Barcelona, 13 December 2019. Presentations • Vernet-Tomas MM, Louro J, Román M, Saladie F, Posso M, Prieto M, Vázquez I, Baré M, Peñalva L, Vidal C, Bargalló X, Sánchez M, Ferrer J, Espinàs JA, Quintana MJ, Rodríguez-Arana A, Castells X. Le risque de diagnostiguer un càncer pendant les deux ans qui suivent une biopsie benigne du sein est relié à l’image décrite en mammographie qui a subi la biopsie. 41es Journées de la Société Française de Sénologie et de Pathologie Mammaire. Marseille, 6-8 November 2019. • Posso M, Louro J, Román M, Domingo L, Castells S, Sala M. Individualized breast càncer risk prediction models in average-risk women: a systematic review and quality assessment. International Cancer Screening Conference. Rotterdam, The Netherlands, 3-5 June 2019. • Román M, Domingo L, Posso M, Louro J, Castells X, Sala M. A systematic review of personalized breast cancer screening strategies. International Cancer Screening Conference. Rotterdam, The Netherlands, 3-5 June 2019. • Louro J, Castells X, Quintana MJ, Posso M, Sala M, Román M. An individualized breast cancer risk prediction model to personalized mammography screeningInternational Cancer Screening Conference. Rotterdam, The Netherlands, 3-5 June 2019. Dissemination to Society and Initiatives of Citizen Participation • Sala M, Castell X, Posso MC, Roman M, Louro J, Domingo L, et al. with the participation of the Associació AGATA (Catalan Association of Women Affected by Breast Cancer). Report: Evidence on personalising the population-based breast cancer screening. Barcelona: Agència de Qualitat i Avaluació Sanitàries de Catalunya. Departament de Salut. Generalitat de Catalunya; 2019 (Health Technology Assessment Reports). • Andrea Burón, Francesc Macià. Dissemination of the Early Detection of Colon and Rectal Cancer Program by participating in the Bicycle Party. Agència de Salut Pública de Barcelona (ASPB), 24 March 2019. • Dissemination of the Early Detection of Colon and Rectal Cancer Program by participating in the Urban Walk. Ajuntament de Barcelona and Associació d’Entitats Excursionistes del Barcelonès. Barcelona, 12 May 2019. • Dissemination of the Early Detection of Colon and Rectal Cancer Program by participating in the La Mina Entity Fair. CAP La Mina. Barcelona, 29 May 2019. 24 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY
Girona Heart Registry
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Jaume Marrugat de la Iglesia
Irene Román Dégano (Researcher)
jmarrugat@imim.es Silvia Pérez Fernández (Technician)
Pau Raduà Roy (Technician)
Sussanna Tello Rovira (Technician)
Joan Salvador Vila Domènech (Technician)
Sandra Farré Anton (Research Assistant)
Yolanda Ferrer Campo (Research Assistant)
Sonia Gaixas Vasallo (Research Assistant)
The mission of the Girona Heart Registry Research Group is to increase our knowledge
of the magnitude of the populational problem of cardiovascular diseases, their
molecular, cellular, and environmental mechanisms, and to design the best strategies for
preventing them.
The ultimate goal for this knowledge is to significantly reduce this disease’s burden on
society, creating tools (such as cardiovascular risk funcions) that allow us to transfer the
knowledge we acquire to clinical practice.
The REGICOR Group also has the mission of training new researchers in this area of
knowledge, and has been accredited with the Recognition for Advanced Research by
the Catalan Government every two years since 1996.
The REGICOR project is well known for having recruited some 11,000 participants
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 25Epidemiology and Public Health Girona Heart Registry
in population surveys and over 3,000 consecutive acute myocardial infarction (AMI)
patients and for having compiled a biobank of DNA and plasma samples between 1995
and 2005 in Girona. The first-ever description of AMI incidence among the population
in Spain was published by the REGICOR team.
The cardiovascular research project of the REGICOR has yielded over 500 international
scientific publications. The REGICOR team has extensive experience in leading
collaborative research at the international level. REGICOR promotes a multidisciplinary
approach to research from different perspectives (biochemical, molecular,
epidemiological, clinical, and genetic) that enriches the study of multifactorial processes
such as cardiovascular disease.
The group’s research lines focus on descriptive and clinical epidemiology with follow-up
of the incidence of AMI and classic risk factors. They have analysed prognostic factors
and the incidence of AMI, including biochemical and epigenetic markers, as well as
cardiovascular risk, with the development and improvement of cardiovascular risk
functions adapted to our environment.
Main Publications
• Hernáez Á, Zomeño MD, Dégano IR, Pérez-Fernández S, Goday A, Vila JS, Civeira
F, Moure R, Marrugat J. Exceso de peso en España: situación actual, proyecciones
para 2030 y sobrecoste directo estimado para el Sistema Nacional de Salud. Rev Esp
Cardiol 2019; 72(11): 916-924. IF 5.126. Q1.
• Subirana I, Fernández-Avilés F, Elosua R, Lidón RM, García-Dorado D, Marrugat J,
investigadores del estudio ATHOS. Variabilidad interhospitalaria del tratamiento del
síndrome coronario agudo en el estudio ATHOS. Rev Esp Cardiol 2019; 72(8): 691-
693. IF 5.126. Q1.
• Sayols-Baixeras S, Fernández-Sanlés A, Prats A, Subirana I, Plusquin M, Künzli N,
Marrugat J, Basagaña X, Elosua R. Association between long-term air pollution
exposure and DNA methylation: The REGICOR study. Environ Res 2019; 176:
108550. IF 5.026. Q1.
• De Gonzalo D, Elosua R, Vea A, Subirana I, Sayols-Baixeras S, Marrugat J, Llorente-
Cortés V. Soluble low-density lipoprotein receptor-related protein 1 as a biomarker of
coronary risk: Predictive capacity and association with clinical events. Atherosclerosis
2019; 287: 93-99. IF 4.255. Q2.
• García-Gil M, Comas-Cufí M, Ramos R, Martí R, Alves-Cabratosa L, Parramon D,
Prieto-Alhambra D, Baena-Díez JM, Salvador-González B, Elosua R, Dégano IR,
Marrugat J, Grau M. Effectiveness of Statins as Primary Prevention in People With
Gout: A Population-Based Cohort Study. J Cardiovasc Pharmacol Ther 2019; 24(6):
542-550. IF 2.57. Q2.
See all Publications
26 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Girona Heart Registry
Ongoing Research Projects
• Role of micro RNAs expressed by human endothelial and vascular smooth muscle cells
in myocardial infarction. (MIRMID: micro RNAs in Myocardial Infarction Disease)
- Financing institution: Fundación BBVA (PR-16_BIO_CAR_0041)
- Period: from 2016 to 2019
- Principal investigator: Marrugat de la Iglesia, Jaume
• Validation of a coronary heart disease risk calculator adapted to Human
Immunodeficiency Virus infected patients. The COMVIH-COR project
- Financing institution: Gilead Sciences S.L.U (GLD17-00224)
- Period: from 2018 to 2020
- Principal investigator: Marrugat de la Iglesia, Jaume
• Optimization and assessment of high-, intermediate- and low-risk cut-points of
cardiovascular risk functions used in primary prevention
- Financing institution: Instituto de Salud Carlos III (PI18/00030)
- Period: from 2019 to 2021
- Principal investigator: Marrugat de la Iglesia, Jaume
• PrevCardio: Desarrollo de una herramienta para la prevención personalizada de la
enfermedad cardiovascular en población general
- Financing institution: Sociedad Española de Cardiología
- Period: from 2019 to 2020
- Principal investigator: Marrugat de la Iglesia, Jaume
See all Projects
Participation in Research Networks
• CIBER Enfermedades Cardiovasculares
- Financing institution: Fondo de Investigación Sanitaria. ISCIII (CB16/11/00229)
- Period: from 2003
- Principal investigator: Marrugat de la Iglesia, Jaume
> SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 27Epidemiology and Public Health Girona Heart Registry
Clinical Trials Signed in 2019
• Preparation and implementation of the study protocol “Ensayo clínico abierto, no
aleatorizado en dos conglomerados constituidos por dos poblaciones urbanas
distintas, comparativo de una intervención preventiva con un grupo control
sin intervención sobre el control de factores de riesgo cardiovascular. Healthy
Communities”.
- Sponsor: Fundació Privada SHE
- Budget: 62,600 €
- Principal investigator: Marrugat de la Iglesia, Jaume
• A standardized comparison of cardiovascular risk factor prevalence between HIV-
infected patients and general population & cost-effectiveness of treating dyslipemia in
high cardiovascular risk patients
- Protocol: IN-ES-985-5373
- Sponsor: Gilead Sciences, S.L.U.
- Budget: 72,360 €
- Principal investigator: Marrugat de la Iglesia, Jaume
Awards
• Marrugat de la Iglesia, Jaume; Román Dégano, Irene. 2019 Second prize for the most-
cited article, long-term in Revista Española de Cardiología Journal. Sociedad Española
de Cardiología (SEC). 18/10/2019.
• Marrugat de la Iglesia, Jaume; Román Dégano, Irene. Prize for the best Primary Care
article. Col·legi Oficial de Metges de Barcelona. 27/11/2019.
Appointments
• Jaume Marrugat. Member of Scientific Committee. CODI IAM. Departament de Salut
de la Generalitat de Catalunya. 2018 to date.
• Jaume Marrugat. Member of Scientific Committee. Agència de Qualitat i Avaluació
Sanitàries de Catalunya (AQUAS). 2018 to date.
28 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Girona Heart Registry Outreach Dissemination to Society and Initiatives of Citizen Participation • Gaixas Sònia, Román Dégano Irene, Pérez-Fernández Sílvia. Workshop Mesure your cardiovascular health. Open Day of the Parc de Recerca Biomèdica de Barcelona (PRBB), 5 October 2019. • Irene Román, Susanna Tello. Excursion through the different stages of a research project. High school students form the Institut Secretari Coloma. Escolab Project. Barcelona Science Programme of the Institute of Culture. 21 March 2019. • Jaume Marrugat. Conference on risk and fears. Biblioteca Can Fabra, Barcelona, 14 February 2019. > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 29
Health Services
> Epidemiology and Public Health RESEARCH GROUP
Group Leader Members
Jordi Alonso Caballero
María Jesús Blasco Cubedo (Researcher)
jalonso@imim.es Olatz Garin Boronat (Researcher)
Montserrat Ferrer Forés (Researcher)
Antón López Alfonso (Researcher)
Philippe Mortier (Researcher)
Yolanda Pardo Cladellas (Researcher)
Gemma Vilagut Saiz (Researcher)
Laura Ballester Coma (PhD Student)
Ana de Inés Trujillo (PhD Student)
Karina Mayoral Ortiz (PhD Student)
Beatriz Puértolas Gracia (PhD Student)
Itxaso Alayo Bueno (Technician)
Javier Gómez Sánchez (Technician)
Àngels Pont Acuña (Technician)
Purificación Barbas López (Research Assistant)
Carme Gasull Planes (Research Assistant)
Luisa Aurea Martín Morris (Research Assistant)
Our research focuses on methods for measuring perceived health, patient-reported
outcomes (PROs), disability and the burden of disease. Our main areas of research
apply these methods to assessing the burden of common mental health disorders
and to evaluating the comparative effectiveness of interventions for chronic diseases,
especially in cancer and asthma. Our research is carried out in collaboration with several
30 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARYEpidemiology and Public Health Health Services international research networks, including the World Mental Health (WMH) Surveys Consortium, and TrueNTH Global Registry – Prostate Cancer Outcomes, a Movember Foundation international initiative. Knowledge transfer is also an important focus for the group, which plays a leading role in BiblioPRO, the online library of PROs in Spanish containing more than 2300 instruments, which is now going to cover all languages with the new website BiblioPRO International. We have developed a tool to evaluate the quality of these instruments (EMPRO) and a “Procedure and system to evaluate the quality of life related to the health of an individual” (patent n P200600211, May 1999). In addition, we collaborate as partners in international research initiatives and projects, such as SISAQOL, PROMIS- Health Organization, ICHOM, OECD-PaRIS, IQOD, MHADIE, KIDSCREEN, ASTRO- LAB, or EuroQol. We are engaged in a number of educational and mentoring activities, including the Master’s programme in Public Health, the degree in Medicine, and other official education from both Pompeu Fabra University (UPF) and the Autonomous University of Barcelona (UAB), as well as the PSMAR Teaching Unit of Specialists in Preventive Medicine and Public Health. Our team comprises some 15 professionals with different backgrounds, such as life sciences, psychology, statistics, and others; it is part of the CIBER de Epidemiología y Salud Pública (CIBERESP) of the Instituto de Salud Carlos III, and is recognized as a consolidated research group by the Generalitat de Catalunya. Main Publications • Soto-Sanz V, Castellví P, Piqueras JA, et al. Internalizing and externalizing symptoms and suicidal behavior in young people: a systematic review and meta-analysis of longitudinal studies. Acta Psychiatr Scand 2019; 140(1): 5-19. IF 4.984. Q1. • Hernández G, Garin O, Dima AL, et al. EuroQol (EQ-5D-5L) Validity in Assessing the Quality of Life in Adults With Asthma: Cross-Sectional Study. J Med Internet Res 2019; 21(1): e10178 IF 4.945. D1. • Mayoral K, Rajmil L, Murillo M, et al. Measurement Properties of the Online EuroQol- 5D-Youth Instrument in Children and Adolescents with Type 1 Diabetes Mellitus: Questionnaire Study. J Med Internet Res 2019; 21(11): e14947. IF 4.945. D1. • Miranda-Mendizábal A, Castellví P, Alayo I, et al. Gender commonalities and differences in risk and protective factors of suicidal thoughts and behaviors: A cross- sectional study of Spanish university students. Depress Anxiety 2019; 36(11): 1102- 1114. IF 4.935. D1. • Blasco-Cubedo MJ, Vilagut G, Almenara J, et al. Suicidal Thoughts and Behaviors: Prevalence and Association with Distal and Proximal Factors in Spanish University Students. Suicide Life Threat Behav 2019; 49(3): 881-898. IF 3.032. Q1. See all Publications > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 31
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