EU Health research : A decade of EU efforts on epilepsy research - Dr Karim Berkouk. Acting Head of Unit - epiXchange
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EU Health research :
A decade of EU efforts on epilepsy
research
Dr Karim Berkouk. Acting Head of Unit
Non-Communicable Diseases & the Challenge
of Healthy Ageing
Health Directorate
Directorate General Research and Innovation
European Commission
Epilepsy – Why are we here today?
Burden
• 68 million people affected worldwide
• Epilepsy puts a significant economic burden on
societies worldwide – EUR 16 billion/year
Current challenges
• Lack of early intervention/proper diagnosis
• Lack of effective treatment for 30-40% of patients
• Large spectrum of disorders - Lack of personalised approach
• Strong link to other disorders (TBI, depression, mental
disability, etc.)
• Social stigma
Image credit: © luaeva, #104643250, 2018. Source: Fotolia.com.
Over a decade of EU efforts in epilepsy research
200
H2020 FP7
180
160
140
Millions in EUR
120
100
80
60
40
20
0
FP H2020
7
EU epilepsy research funded in FP7 & Horizon 2020
Key Figures
4 • 104 projects
17
• 431 participations
• Over 50 countries
57 In Health Programme (7
26 Closed projects)
• 260 publications
• 6,6 average Impact Factor
Training & mobility Frontier research
• 2 SMEs; 1 patent
Collaborative research Innovation
€ 178 million (2007-2018)
EC Contribution by region (FP7 only)
EC Initiatives
6
epiXchange – emerging global leader in epilepsy research
Global partners
US: 4; AU: 2; IL: 1, BR: 1
EpiTarget
EpimiRNA 20 participants
19 participants
EpiPGX
15 participants
EpiSTOP
17 participants
EpiCARE
28 participants
DESIRE
28 participants
epiXchange
4 participants
2011 - EpiPGX, epiXchange
2013 - DESIRE, EpiSTOP,
EpiTarget, EpimiRNA
2016 - ERN EpiCARE
EC initiatives: Public partnerships
• Build the European dimension in MS
research activities
• Support and align national strategies
• Co-invest in brain, cancer & cardiovascular
diseases
• Provide best practises to MS
Creating research infrastructures
Building a research infrastructure to help advance
neuroscience, medicine and computing.
• Over 500 scientists at nearly 120 universities,
teaching hospitals and research centres across
Europe
• Optimise use of available resources (data and
knowledge)
• Accelerate data analysis
• Provide sustainable infrastructure for
neuroscience data
• Broaden the knowledge-base
• Accelerate innovation for patients
• Speed up clinical validation
EC initiatives: Public-private partnerships
• The world's biggest PPP in life sciences
• Aims to improve the development of
medicines, vaccines etc.
Total funding in brain • Open to other industries
research: 250 Million EUR • Unprecedented inter-industry
collaboration and with academia,
patients, regulators, authoritiesOur initiatives: Global co-operation
• International funders
• Flexible arrangements
• Common goal
• Mobilisation of a critical mass of
researchers
• Sharing of tasks, costs, research
infrastructures and data
• Taking advantage of different practicesSome successes: Detecting early DESIRE, EpiSTOP EpimiRNA, EpiTarget
Some successes: Anticipating patients' seizures
Main objective:
To develop an intelligent alarming system for a
patient which measures brain dynamical activity and
is capable of predicting the seizures to increase
patient's safety.
Outcomes:
• Development of EPILAB - a software package for
studies on the prediction of epileptic seizures
• Development of the European database on epilepsy
patients which includes EEG recordings, MR, etc.
• Development of the first portable devices for
monitoring seizures at home by MICROMEDSome successes: Picturing the inside
functioning of the brain
NEUROPT
Main objective:
The development of advanced non-invasive imaging
methodologies for in vivo diagnosis, monitoring and
prognosis of major neurological diseases.
Outcomes:
• Improvement of the spatial resolution of imaging
techniques
• Employment of the time-resolved techniques to
offer greater sensitivity while imaging surface
tissues (e.g. skin and skull) and brain tissue.
• Development of the novel photonic devices as well
as device prototypes for use in the clinical setting,
including a specialised helmet for attaching the
optical fibres to the head.Current funding opportunities for epilepsy research
WP 2019 - 2020
• Understanding causative mechanisms in co- and multimorbidities
• New therapies for NCDs
• Management of multimorbidities (elderly)
• Digital health and care services
• International cooperation in digital solutions and robotics for independent living
EC Coordination and support actions
• Coordinating European brain research and developing global initiatives
• Building international efforts on population and patient cohorts
Other opportunities:
• Translational Safety Biomarker Pipeline (TransBioLine): Enabling development
and implementation of novel safety biomarkers in clinical trials and diagnosis of
disease (IMI2)
• Testing pathophysiological models of brain diseases - Medical Informatics
Platform (HBP)
• Federated analysis of human intracerebral stimulation and recording data
• 2018 "Mental Disorders" Call (NEURON)Horizon Europe: Proposed structure
Horizon Europe: Budget Proposal Proposed budget: €97.9 billion
TOWARDS Horizon Europe: MISSIONS
HIGH LEVEL
GROUP
CHAIRED BY
PASCAL LAMY
Adopt a mission-oriented, impact-focused
approach to address global challenges
Action: Set research and innovation missions that address
global challenges and mobilise researchers, innovators and
other stakeholders to realise them.Criteria for selecting R&I missions Proposed by Prof. Mazzucato • Bold, inspirational, with wide societal relevance • A clear direction: Targeted, measurable and time-bound • Ambitious but realistic R&I actions • Cross-disciplinary, cross-sectoral and cross- actor innovation • Multiple bottom-up solutions
Conclusions
A decade of achievements
• Advances in brain imaging, genetic and metabolic investigations
• Identification of over 130 subcategories of epilepsy
• Impacting clinical practice: better diagnosis and care of patients
• Europe as a strong contributor to epilepsy research
EU research shows that together we can
achieve better, more and faster!
The new decade starts now with the end of
H2020 and the beginning of Horizon EuropeThank you!
@EUScienceInnov
#InvestEUresearch
#EUHealthResearch
http://ec.europa.eu/research/health
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