Lung Cancer Prevention and Early Detection

Lung Cancer Prevention and Early Detection

Lung Cancer Prevention and Early Detection

Lung Cancer Prevention and Early Detection Lung cancer is the second most common cancer in both men and women (not counting skin cancer), and is by far the leading cause of cancer death among both men and women. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. Most lung cancers could be prevented, because they are related to smoking (or secondhand smoke), or less often to exposure to radon or other environmental factors. But some lung cancers occur in people without any known risk factors for the disease. It is not yet clear if these cancers can be prevented.

Most lung cancers have already spread widely and are at an advanced stage when they are first found. These cancers are very hard to cure. But in recent years, doctors have found a test that can be used to screen for lung cancer in people at high risk of the disease. This test can help find some of these cancers early, which can lower the risk of dying from this disease. What is lung cancer? Lung cancer is a cancer that starts in the lungs. To understand lung cancer, it helps to know about the normal structure and function of the lungs.

The lungs Your lungs are 2 sponge-like organs found in your chest.

Your right lung is divided into 3 sections, called lobes. Your left lung has 2 lobes. The left lung is smaller because the heart takes up more room on that side of the body.

Lung Cancer Prevention and Early Detection

When you breathe in, air enters through your mouth or nose and goes into your lungs through the trachea (windpipe). The trachea divides into tubes called the bronchi (singular, bronchus), which enter the lungs and divide into smaller bronchi. These divide to form smaller branches called bronchioles. At the end of the bronchioles are tiny air sacs known as alveoli. Many tiny blood vessels run through the alveoli. They absorb oxygen from the inhaled air into your bloodstream and pass carbon dioxide from the body into the alveoli. This is expelled from the body when you exhale. Taking in oxygen and getting rid of carbon dioxide are your lungs’ main functions.

A thin lining layer called the pleura surrounds the lungs. The pleura protects your lungs and helps them slide back and forth against the chest wall as they expand and contract during breathing. Below the lungs, a thin, dome-shaped muscle called the diaphragm separates the chest from the abdomen. When you breathe, the diaphragm moves up and down, forcing air in and out of the lungs.

Lung Cancer Prevention and Early Detection

Start and spread of lung cancer Lung cancers can start in the cells lining the bronchi and parts of the lung such as the bronchioles or alveoli. Lung cancers are thought to start as areas of pre-cancerous changes in the lung.

The first changes in the genes (DNA) inside the lung cells may cause the cells to grow faster. These cells may look a bit abnormal if seen under a microscope, but at this point they do not form a mass or tumor. They cannot be seen on an x-ray and they do not cause symptoms. Over time, the abnormal cells may acquire other gene changes, which cause them to progress to true cancer. As a cancer develops, the cancer cells may make chemicals that cause new blood vessels to form nearby. These blood vessels nourish the cancer cells, which can continue to grow and form a tumor large enough to be seen on imaging tests such as x-rays.

At some point, cells from the cancer may break away from the original tumor and spread (metastasize) to other parts of the body. Lung cancer is often a life-threatening disease because it tends to spread in this way even before it can be detected on an imaging test such as a chest x-ray. Types of lung cancer There are 2 main types of lung cancer: • Small cell lung cancer (SCLC) • Non-small cell lung cancer (NSCLC) Small cell lung cancer About 10% to 15% of all lung cancers are small cell lung cancer (SCLC), named for the size of the cancer cells when seen under a microscope. Other names for SCLC are oat cell cancer, oat cell carcinoma, and small cell undifferentiated carcinoma.

It is very rare for someone who has never smoked to have small cell lung cancer. SCLC often starts in the bronchi near the center of the chest, and it tends to spread widely through the body early in the course of the disease. This cancer is discussed in our document Lung Cancer (Small Cell).

Non-small cell lung cancer About 85% to 90% of lung cancers are non-small cell lung cancer (NSCLC). There are 3 main subtypes of NSCLC. The cells in these subtypes differ in size, shape, and chemical

make-up. But they are grouped together because the approach to treatment and prognosis (outlook) are often very similar. Squamous cell (epidermoid) carcinoma: About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the middle of the lungs, near a bronchus.

Adenocarcinoma: About 40% of lung cancers are adenocarcinomas. These cancers start in early versions of the cells that would normally secrete substances such as mucus. This type of lung cancer occurs mainly in current or former smokers, but it is also the most common type of lung cancer in non-smokers. It is more common in women than in men, and it is more likely to occur in younger people than other types of lung cancer. Adenocarcinoma is usually found in the outer parts of the lung. It tends to grow slower than other types of lung cancer, and is more likely to be found before it has spread outside of the lung.

People with a type of adenocarcinoma called adenocarcinoma in situ (previously called bronchioloalveolar carcinoma) tend to have a better outlook (prognosis) than those with other types of lung cancer. Large cell (undifferentiated) carcinoma: This type of cancer accounts for about 10% to 15% of lung cancers. It can appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer.

Other subtypes: There are also a few other subtypes of non-small cell lung cancer, such as adenosquamous carcinoma and sarcomatoid carcinoma.

These are much less common. For more information about non-small cell lung cancer, see our document Lung Cancer (Non-Small Cell). Other types of lung cancer Along with the 2 main types of lung cancer, other tumors can occur in the lungs. Lung carcinoid tumors: Carcinoid tumors of the lung account for fewer than 5% of lung tumors. Most are slow-growing tumors that are called typical carcinoid tumors. They are generally cured by surgery. Some typical carcinoid tumors can spread, but they usually have a better prognosis than small cell or non-small cell lung cancer. Less common are atypical carcinoid tumors.

The outlook for these tumors is somewhere in between typical carcinoids and small cell lung cancer. For more information about typical and atypical carcinoid tumors, see our document Lung Carcinoid Tumor.

Other lung tumors: Other types of lung cancer such as adenoid cystic carcinomas, lymphomas, and sarcomas, as well as benign lung tumors such as hamartomas are rare. These have different risk factors from the more common lung cancers. They are not discussed in this document. Cancers that spread to the lungs: Cancers that start in other organs (such as the breast, pancreas, kidney, or skin) can sometimes spread (metastasize) to the lungs, but these are not lung cancers. For example, cancer that starts in the breast and spreads to the lungs is still breast cancer, not lung cancer. Treatment for cancer that has spread to the lungs is based on which type of cancer it is.

What are the risk factors for lung cancer? A risk factor is anything that affects a person’s chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed. But risk factors don’t tell us everything. Having a risk factor, or even several risk factors, does not mean that you will get the disease. And some people who get the disease may not have had any known risk factors. Even if a person with lung cancer has a risk factor, it is often very hard to know how much that risk factor may have contributed to the cancer.

Several risk factors can make you more likely to develop lung cancer. Tobacco smoke Smoking is by far the leading risk factor for lung cancer. In the early 20th century, lung cancer was much less common than some other types of cancer. But this changed once manufactured cigarettes became readily available and more people began smoking. At least 80% of lung cancer deaths are thought to result from smoking. The risk for lung cancer among smokers is many times higher than among non-smokers. The longer you smoke and the more packs a day you smoke, the greater your risk. Cigar smoking and pipe smoking are almost as likely to cause lung cancer as cigarette smoking.

Smoking low-tar or “light” cigarettes increases lung cancer risk as much as regular cigarettes. There is concern that menthol cigarettes may increase the risk even more since the menthol allows smokers to inhale more deeply.

Secondhand smoke: If you don’t smoke, breathing in the smoke of others (called secondhand smoke or environmental tobacco smoke) can increase your risk of developing lung cancer by about 30%. Secondhand smoke is thought to cause more than 7,000 deaths from lung cancer each year.

Some evidence suggests that certain people are more susceptible to the cancer-causing effect of tobacco smoke than others. If you or someone you care about needs help in quitting, see our document Guide to Quitting Smoking or call the American Cancer Society at 1-800-227-2345. Radon Radon is a naturally occurring radioactive gas that results from the breakdown of uranium in soil and rocks.

It cannot be seen, tasted, or smelled. According to the US Environmental Protection Agency (EPA), radon is the second leading cause of lung cancer in this country, and is the leading cause among non-smokers. Outdoors, there is so little radon that it is not likely to be dangerous. But indoors, radon can be more concentrated. When it is breathed in, it enters the lungs, exposing them to small amounts of radiation. This may increase a person’s risk of lung cancer. The lung cancer risk from radon is much lower than that from tobacco smoke. However, the risk from radon is much higher in people who smoke than in those who don’t.

Radon levels in the soil vary across the country, but they can be high almost anywhere. Homes in some parts of the United States built on soil with natural uranium deposits can have high indoor radon levels (especially in basements). Studies from these areas have found that the risk of lung cancer is higher in those who have lived for many years in a radon-contaminated house.

If you are concerned about radon exposure, you can use a radon detection kit to test the levels in your home. State and local offices of the EPA can also give you the names of reliable companies that can test your home (or other buildings) for radon and help you fix the problem, if needed. For more information, see our document called Radon. Asbestos Workplace exposure to asbestos fibers is an important risk factor for lung cancer. Studies have found that people who work with asbestos (in some mines, mills, textile plants, places where insulation is used, shipyards, etc.) are several times more likely to die of lung cancer.

In workers exposed to asbestos who also smoke, the lung cancer risk is much greater than even adding the risks from these exposures separately. It’s not clear to what extent low-level or short-term exposure to asbestos might raise lung cancer risk. Both smokers and non-smokers exposed to asbestos also have a greater risk of developing mesothelioma, a type of cancer that starts in the pleura (the lining surrounding the lungs). Because it is not usually considered a type of lung cancer, mesothelioma is discussed in our document called Malignant Mesothelioma.

In recent years, government regulations have greatly reduced the use of asbestos in commercial and industrial products. It is still present in many homes and other older buildings, but it is not usually considered harmful as long as it is not released into the air by deterioration, demolition, or renovation. For more information, see our document called Asbestos. Other cancer-causing agents in the workplace Other carcinogens (cancer-causing agents) found in some workplaces that can increase lung cancer risk include: • Radioactive ores such as uranium • Inhaled chemicals or minerals such as arsenic, beryllium, cadmium, silica, vinyl chloride, nickel compounds, chromium compounds, coal products, mustard gas, and chloromethyl ethers • Diesel exhaust The government and industry have taken steps in recent years to help protect workers from many of these exposures.

But the dangers are still present, so if you work around these agents, you should be careful to limit your exposure whenever possible. Air pollution In cities, air pollution (especially near heavily trafficked roads) appears to raise the risk of lung cancer slightly. This risk is far less than the risk caused by smoking, but some researchers estimate that worldwide about 5% of all deaths from lung cancer may be due to outdoor air pollution.

Radiation therapy to the lungs People who have had radiation therapy to the chest for other cancers are at higher risk for lung cancer, particularly if they smoke. Typical patients are those treated for Hodgkin disease or women who get radiation after a mastectomy for breast cancer. Women who receive radiation therapy to the breast after a lumpectomy do not appear to have a higher than expected risk of lung cancer. Arsenic in drinking water Studies of people in parts of Southeast Asia and South America with high levels of arsenic in their drinking water have found a higher risk of lung cancer.

In most of these studies, the levels of arsenic in the water were many times higher than those typically seen in the United States, even in areas where arsenic levels are above normal. For most

Americans who are on public water systems, drinking water is not a major source of arsenic. Personal or family history of lung cancer If you have had lung cancer, you have a higher risk of developing another lung cancer. Brothers, sisters, and children of those who have had lung cancer may have a slightly higher risk of lung cancer themselves, especially if the relative was diagnosed at a younger age. It is not clear how much of this risk might be due to inherited genes and how much might be from shared household exposures (such as tobacco smoke or radon). Researchers have found that genetics does seem to play a role in some families with a strong history of lung cancer.

For example, people who inherit certain DNA changes in a particular chromosome (chromosome 6) are more likely to develop lung cancer, even if they don’t smoke or only smoke a little. At this time these DNA changes cannot be routinely tested for. Research is ongoing in this area.

Certain dietary supplements Studies looking at the possible role of vitamin supplements in reducing lung cancer risk have not been promising so far. In fact, 2 large studies found that smokers who took beta carotene supplements actually had an increased risk of lung cancer. The results of these studies suggest that smokers should avoid taking beta carotene supplements. Factors with uncertain or unproven effects on lung cancer risk Marijuana smoking There are some reasons to think that marijuana smoking might increase lung cancer risk. Marijuana smoke contains tar and many of the same cancer-causing substances that are in tobacco smoke.

(Tar is the sticky, solid material that remains after burning, and is thought to contain most of the harmful substances in smoke.) Marijuana cigarettes (joints) are typically smoked all the way to the end, where tar content is the highest. Marijuana is also inhaled very deeply and the smoke is held in the lungs for a long time, which gives any cancer causing substances more opportunity to deposit in the lungs. And because marijuana is often an illegal substance, it may not be possible to control what other substances it might contain.

But those who use marijuana tend to smoke less marijuana in a day or week than the amount of tobacco consumed by cigarette smokers. For example, a light smoker may smoke half of a pack (10 cigarettes) a day, but 10 marijuana cigarettes in a day would be very heavy use of marijuana. In one study, most people who smoked marijuana did so 2

to 3 times per month. The lesser amount smoked would make it harder to see an impact on lung cancer risk. It has been hard to study whether there is a link between marijuana and lung cancer because marijuana was illegal in many countries for so long, and it is not easy to gather information about the use of illegal drugs.

Also, in the studies that looked at past marijuana use in people who had lung cancer, most of the marijuana smokers also smoked cigarettes. This can make it hard to know how much of the risk is from tobacco and how much might be from marijuana. More research is needed to know the cancer risks from smoking marijuana.

Talc and talcum powder Talc is a mineral that in its natural form may contain asbestos. Some studies have suggested that talc miners and millers might have a higher risk of lung cancer and other respiratory diseases because of their exposure to industrial grade talc. But other studies have not found an increase in lung cancer rate. Talcum powder is made from talc. By law since 1973, all home-use talcum products (baby, body, and facial powders) in the United States have been asbestos-free. The use of cosmetic talcum powder has not been found to increase the risk of lung cancer. Do we know what causes lung cancer?

We don’t know what causes each case of lung cancer. But we do know many of the risk factors for these cancers and how some of them cause cells to become cancerous. Smoking Tobacco smoking is by far the leading cause of lung cancer. At least 80% of lung cancer deaths are caused by smoking, and many others are caused by exposure to secondhand smoke. Smoking is clearly the strongest risk factor for lung cancer, but it often interacts with other factors. Smokers exposed to other known risk factors such as radon and asbestos are at even higher risk. Not everyone who smokes gets lung cancer, so other factors like genetics likely play a role as well (see below).

Lung cancer in non-smokers Not all people who get lung cancer are smokers. Many people with lung cancer are former smokers, but many others never smoked at all.

Lung cancer in non-smokers can be caused by exposure to radon, secondhand smoke, air pollution, or other factors. Workplace exposures to asbestos, diesel exhaust, or certain other chemicals can also cause lung cancers in some people who do not smoke. A small portion of lung cancers occur in people with no known risk factors for the disease. Some of these might just be random events that don’t have an outside cause, but others might be due to factors that we don’t yet know about.

Lung cancers in non-smokers are often different in some ways from those that occur in smokers. They tend to occur at younger ages. Lung cancers in non-smokers often have certain gene changes that are different from those in tumors from smokers. Gene changes that may lead to lung cancer Scientists now know how some of the risk factors for lung cancer can cause certain changes in the DNA of lung cells. These changes can lead to abnormal cell growth and, sometimes, cancer. DNA is the chemical in each of our cells that makes up our genes – the instructions for how our cells function. We usually look like our parents because they are the source of our DNA.

But DNA affects more than how we look. It also can influence our risk for developing certain diseases, including some kinds of cancer. Some genes contain instructions for controlling when cells grow, divide to make new cells, and die. Genes that help cells grow and divide are called oncogenes. Genes that slow down cell division or cause cells to die at the right time are called tumor suppressor genes. Cancers can be caused by DNA changes that turn on oncogenes or turn off tumor suppressor genes.

Inherited gene changes Some people inherit DNA mutations (changes) from their parents that greatly increase their risk for developing certain cancers. But inherited mutations alone are not thought to cause very many lung cancers. Still, genes do seem to play a role in some families with a history of lung cancer. For example, some people seem to inherit a reduced ability to break down or get rid of certain types of cancer-causing chemicals in the body, such as those found in tobacco smoke. This could put them at higher risk for lung cancer.

Other people may inherit faulty DNA repair mechanisms that make it more likely they will end up with DNA changes.

Every time a cell divides into 2 new cells, it must make a new copy of its DNA. This process is not perfect, and copying errors sometimes occur. Cells normally have repair enzymes that proofread the DNA to help prevent this. People with repair enzymes that don’t work as well might be especially vulnerable to cancer- causing chemicals and radiation.

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