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Meeting Update 2019 www.microscopy.orgMandM/2019 - Microscopy Society of America
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   Plenary Sessions &
    Program Highlights
   Registration Fees
   Special M&M
    Hotel Rates

                        Meeting Update

                                                       2019

                         www.microscopy.org/MandM/2019
               Registration Opens: March 2019 | Book Your Hotel Starting: February 2019
Meeting Update 2019 www.microscopy.orgMandM/2019 - Microscopy Society of America
Join Us August 4-8, 2019 in Portland, Oregon!

                                                    On behalf of the Microscopy Society of
                                                    America (MSA), the Microanalysis Society
                                             2019   (MAS), and the International Field Emission
                                                    Society (IFES), we are excited to invite you
                                                    to Microscopy & Microanalysis 2019 in
                                                    Portland, Oregon.

                                                    As many of you who have previously visited Portland know, this
                                                    city is a terrific location for our meeting: set between Mt. Hood
    Questions?                                      and the Pacific coast, Portland (PDX to locals) presents a variety
    TECHNICAL MEETING CONTENT:                      of attractions for everybody. Infused with the awesome Pacific
    2019 Program Chair                              Northwest culture of environmental conservation and organic
    Alice Dohnalkova,                               local food sourcing, you will find a lot of wonderful restaurants
    Pacific Northwest National Laboratory
                                                    here, plus a myriad of microbreweries, distilleries and wineries!
    MM2019ProgramChair@microscopy.org
                                                    Don’t forget to visit famous PDX staples like Powell’s Books and
    REGISTRATION:                                   the charismatic Voodoo Donuts. Don’t forget your hiking shoes or
    Registrar                                       beachwear if you’re planning to explore the great outdoors like
    MMRegistration@conferencemanagers.com           the Columbia Gorge area or the Oregon Coast beaches.
    EXHIBITS & EXHIBITORS:
                                                    The meeting itself will be preceded by our usual array of
    Exhibits Manager
    doreen@corcexpo.com                             Sunday Short Courses, two Pre-Meeting Congresses, and our
                                                    Sunday evening Opening Welcome Reception. We will once
    SPONSORS & SPONSORSHIPS:                        again hold a Pre-Meeting Congress featuring outstanding
    Sponsorship Manager                             work by students and early-career researchers.
    mary@corcexpo.com
                                                    The technical program will kick off with our annual Monday
    GENERAL:
    Meeting Manager                                 morning plenary session, featuring the major awards
    meetingmanager@microscopy.org                   ceremonies for the sponsoring societies, the M&M meeting
                                                    awards, and two exciting plenary talks of the 2017 Nobel Prize
    Are You a Member?                               laureates Joachim Frank and Richard Henderson.

    Join Today and Save on M&M 2019                 Immediately following the plenary session, the largest
    Registration Fees                               microscopy/ microanalysis instrument exhibition in the world
                                                    opens to participants. Plan to visit the more than 100 companies
    Visit http://microscopy.org                     displaying their latest technology and services. The social
    to join the Microscopy Society                  activities of the opening reception, and daily “happy hours”
    of America online, or call
                                                    accompanying each day’s poster and awards sessions, have
    1-703-234-41152 for more information about
                                                    become “can’t-miss” events of learning and fellowship.
    the benefits of MSA membership.
                                                    For a complete description of all the symposia, contributed
    Visit
    http://microanalysissociety.org                 sessions, educational opportunities and the multiple award
    to find out the benefits                        possibilities from the three organizing societies, please see
    of MAS membership.                              the Call for Papers (distributed with the November Microscopy
                                                    Today) or go to: http://www.microscopy.org/MandM/2019/.
    Visit
    http://www.fieldemission.org/index.php
                                                    Alice Dohnalkova		              Huolin Xin
    to join the International                       Program Chair			                Program Co-Chair
    Field Emission Society.
                                                    Assel Aitkaliyeva		             Baptiste Gault
                                                    MAS Co-Chair			                 IFES Co-Chair
2         2019
                 August 4-8 | Portland, OR
Meeting Update 2019 www.microscopy.orgMandM/2019 - Microscopy Society of America
Registration & Housing Information
Registration Information for M&M 2019
 • Online registration for the meeting will be available beginning March 4, 2019 at www.microscopy.org/MandM/2019/registration.
 • A valid credit card will be required to register.
 • For questions, please contact MMregistration@conferencemanagers.com.

                                                                                                               Early Rate                                Regular Rate
 Registration Type (see below for details on registration types)
                                                                                                          On or before June 24                         Beginning June 25
                                                                                                         Member*/Non-Member                         Member*/Non-Member

 Full Meeting**                                                                                                $ 480 / $ 595                              $ 595 / $ 720

 Student Full Meeting**†                                                                                        $ 50 / $ 50                                 $ 50 / $ 50

 Emeritus Full Meeting** (requires Emeritus membership in MSA — see below)                                     $195 / $195                                 $ 195 / $ 195

 Post-Doctoral Researcher Full Meeting**                                                                       $ 195 / $ 195                               $ 195 / $ 195

 Partial Meeting – One Day Only              (Monday, Tuesday, Wednesday or Thursday)                          $ 260 / $ 260                              $ 285 / $ 285

 Sunday Short Course        (separate registration required to attend)                                         $ 229 / $ 299                               $ 269 / $ 319

 Student – Sunday Short Course              (separate registration required to attend)                          $ 75 / $ 75                                $ 109 / $ 109

 Pre-Meeting Congresses          (separate registration required)                                              $ 159 / $ 209                              $ 209 / $ 259

 Student – Pre-Meeting Congress†              (separate registration required)                                  $ 75 / $ 75                                $ 109 / $ 109

 Exhibit Hall Only                                                                                                 N/A                                      $ 35 / $ 35

* Member rate applies to any member of MSA, MAS, or IFES. Membership will be verified.
** Emeritus members are for MSA only. To inquire about becoming an MSA Emeritus Member, please contact associationmanagement@microscopy.org
** All Full Meeting Registrations (Regular, Student, Post-Doc, Emeritus) for M&M 2019 include:
   • Copy of (or digital access to) meeting proceedings;
   • Four full days’ access to exhibits, plenary sessions, symposia, tutorials, poster presentations/happy hours, and all vendor tutorials.
      Vendor Tutorials are free and require registration onsite in Oregon at the MSA MegaBooth.
   • Admission ticket + two (2) drink tickets to the Sunday Welcome Reception on Sunday, August 4.
† Student rate is available to full-time undergraduate and graduate students only. Post-doctoral researchers are not considered students.

Book your hotel room in Portland at: http://www.microscopy.org/MandM/2019/hoteltravel/hotel.cfm
Reservations will open February 4, 2019. Special rates are guaranteed until July 5, 2019.
                                                                                                                                                                            Hotel rooms
Book your room through the M&M 2019 Housing and get an immediate reservation confirmation. A valid credit card                                                              will sell fast.
                                                                                                                                                                             Book early
is required to reserve a room. You must book through M&M Housing to get the special meeting rates.                                                                          for the best
                                                                                                                                                                            availability!
Maps showing the location of the hotels and convention center are available on the M&M 2019 site.

 Hotel Name                                 M&M Rate                 Internet     Nightly Parking Rate                    Distance                              Location
                                                                    Included             (subject to change)       from Oregon Convention
                                                                                                                           Center

 Doubletree Portland                       $203–$223                                 $27–self; $37–valet                    4 blocks                   Convention Center/Eastside

 Eastlund Hotel                                 $259                                         $40–valet               1 block / Across street           Convention Center/Eastside

 Crowne Plaza                                   $195                                         $22–self                       4 blocks                   Convention Center/Eastside

 Courtyard by Marriott                          $224                                          $27–self                    2 ½ blocks                   Convention Center/Eastside

                                                                                                                            1.1 miles
 Embassy Suites                                 $252                                 $42–self; $49–valet
                                                                                                                  (15 minutes – MAX light rail)
                                                                                                                                                                 Downtown

                                                                                                                            1.3 miles
 The Benson (historic)                          $224                                         $40–valet
                                                                                                                  (17 minutes – MAX light rail)
                                                                                                                                                                 Downtown

                                                                                                                            2.0 miles
 Portland Marriott Waterfront                   $229                                         $44–valet
                                                                                                                  (17 minutes – MAX Streetcar)
                                                                                                                                                                 Downtown

                                                                                                                            2.1 miles
 Hilton Portland                                $195                                         $50–valet
                                                                                                                  (17 minutes – MAX light rail)
                                                                                                                                                                 Downtown

 Residence Inn / Lloyd Center                   $189                                         $22–self                  8 blocks (.8 mile)              Convention Center/Eastside

                                                                                                                                            www.microscopy.org/MandM/2019
                                                                                                                                                                                  2019        3
Meeting Update 2019 www.microscopy.orgMandM/2019 - Microscopy Society of America
MARK YOUR

    Reminder!                                                          CALENDAR!
                                                                          SUBMISSION
                                                                           DEADLINE:
    Submit your 2-page paper online at:                                 February 15,
    http://microscopy.org/MandM/2019                                       2019

    Look in your November 2018 Microscopy Today to find a printed copy of the
    M&M 2019 Call for Papers, or go to the link below for a downloadable PDF.

    https://www.microscopy.org/MandM/2019/meetings/c4p.pdf

    M&M 2019 sessions will begin Monday, August 5 at 8:30 AM and will end on Thursday, August 8 at 5:00 PM.
    A complete list of symposia and their presentation days will be available on or before May 1, 2019. Presenters
    will receive their presentation day/time information by the end of April. A full scientific program with all
    presentation days and times will be posted around July 1. Please plan your travel accordingly.

    Join your scientific colleagues at these and
    other symposia at M&M 2019, which will
                                                                 Sunday Evening
    showcase the latest innovative applications                  Welcome Reception
    and instrumental developments in the
    biological, physical, and analytical sciences.
                                                                 Sunday, August 4, 2019
    Visit the M&M 2019 website (https://microscopy.              6:30 – 9:00 pm
    org/MandM/2019) for a complete list of symposia,             Oregon Convention Center, Portland Ballroom
    posters, tutorials, workshops, sessions, and pre-meeting
    educational events.                                          One ticket included with most registrations (see
      • Cryo-EM—from Physics to Cell Biology: Honoring the       registration info for details). See registration form
        Remarkable Legacy of Ken Downing                         for additional tickets for adults and children 12 & up
                                                                 (children under 12 are free).
      • The Success of TMBA: TEM and STEM Developments
        in Techniques, Applications and Education                *PLEASE NOTE: Onsite availability of tickets is not
      • Cutting Edge Microscopy in the Pacific Northwest         guaranteed. Buy additional tickets early to be sure
      • Theory and Applications of Electron                      your guests are able to attend.
        Tomography in the Materials Sciences
                                                                 The Sunday Welcome Reception will be
      • Utilizing Microscopy for Research and Diagnosis of
                                                                 held at the Oregon Convention Center
        Diseases in Humans, Plants and Animals
                                                                 in the Portland Ballroom. Find old
      • Electron Crystallography of Nano-structures in           friends and introduce yourself to new
        Nanotechnology, Materials and Bio-Sciences               ones, while enjoying a hearty Pacific
      • New Frontiers in Atom Probe Tomography Applications      Northwest-inspired supper buffet and
      • Current Trends and Challenges in Electron                some of Portland’s favorite locally-
        Energy-Loss Spectroscopy                                 brewed beverages.
      • Data Acquisition Schemes, Machine Learning
        Algorithms, and Open Source Software
        Development for Electron Microscopy
      • Current and Emerging Microscopy for Quantum
        Information Sciences
      • Light and Fluorescence Microscopy for Imaging
        Cell Surface and Structure
      • Low Voltage, Low Energy Electron Microscopy
        Imaging and Analysis
      • Advances in Cryo-EM Technology

4       2019
               August 4-8 | Portland, OR
Meeting Update 2019 www.microscopy.orgMandM/2019 - Microscopy Society of America
Pre-Meeting Congresses & Sunday Short Courses
PRE-MEETING CONGRESSES                                    SUNDAY SHORT COURSES                                 will be discussed, as well as effects of the stage
                                                                                                               and chamber on the detected signals as related
• Registration and additional fee required (register      ORGANIZER:                                           to VPSEM imaging. Brief presentations on their
  online along with your M&M registration)                Donovan Leonard, Oak Ridge National Laboratory       detection systems by Invited manufacturers will be
• See below for details on which meals are                • These full-day courses run from 8:30 AM to         followed by a general discussion. Effects of sample
  included with each event.                                 5:00 PM on Sunday, August 4, 2019                  types, coatings and cleaning will be reviewed.
                                                          • A certificate of participation will be issued      Techniques for resolution measurement, and
X60 Third Annual Pre-Meeting Congress                       to each requesting participant, following          sourcing of suitable samples, will be presented, using
    for Students, Post-Docs, and Early-                     the conclusion of the M&M 2019 meeting.            software provided in the course notes. Questions
    Career Professionals in Microscopy and                • Two (2) Continuing Microscopy Education            are encouraged throughout the day and can also be
    Microanalysis                                           Units are available (registration fee $10          submitted prior to the course, following enrollment.
                                                            for members).
Saturday, August 3, 2019 l 8:30 AM – 5:00 PM              • Morning and afternoon coffee breaks                X13    Modern Electron Crystallography for
Separate registration required.                             are included (breakfast and lunch are                     Materials Sciences and Biology
INCLUDED IN REGISTRATION FEE: Reception,
                                                            on your own).
                                                                                                               LEAD INSTRUCTORS:
                                                          • Separate registration with additional fees
Breakfast, AM Break, Lunch, PM Break, Banquet                                                                  Sergei Rouvimov, University of Notre Dame
                                                            is required (see registration info on M&M
Organized by the MSA Student Council                                                                           Peter Moeck, Portland State University
                                                            website for more information).
                                                                                                               Electron crystallography has many applications in
ORGANIZERS:                                                                                                    nanotechnology, materials and biological sciences.
Ethan L. Lawrence, Arizona State University               X10    High-Resolution Structure                     Due to recent developments in TEM instrumentation,
 (Program Chair)                                                 Determination by Cryo-EM: What                electron crystallography became readily available
Mike Casasanta, Virginia Tech                                    Could Possibly Go Wrong?                      to study nanostructures and biological materials
 (Biological Sciences Co-Chair)                           LEAD INSTRUCTORS:                                    at the nanoscale. This course will address recent
Eric Hoglund, University of Virginia                      Anchi Cheng, New York Structural Biology Center      developments in instrumentation and electron
 (Physical Sciences Co-Chair)
                                                          Steve Ludtke, Baylor College of Medicine             diffraction methods, both experimental techniques
Jeana Owens, Kansas State University                                                                           and computer-based data processing, that allow
                                                          In this one-day course, it is not possible to
 (Activities & Social Events Co-Chair)                    explain and cover all the methods required for       research of a wide range of materials, including
This pre-meeting congress is organized by and for         successfully determining a structure. However,       beam-sensitive materials. The goal is to bring
students, postdocs, and early-career professions,         an overview of the steps, and particularly           together and provide updates for researchers from
and provides:                                             advice on pitfalls to be avoided, will be            both materials and biological sciences on novel
• A unique opportunity to sample award-winning            especially of interest to those who will wish to     techniques for a wide range of materials systems,
   research across diverse areas of research.             employ this method. We will identify the range       and new data analyses and computational methods
                                                          of methods, instrumentation, and software            including their application for cryo-EM.
• A forum for early-career professionals to deliver
   presentations to peers ahead of the meeting.           available, and we will illustrate by means of
• Opportunities to share research and data in an          recent successful results.                           X14    In Situ and Operando Approaches to TEM
   engaging, non-intimidating, and interactive setting.                                                        LEAD INSTRUCTORS:
• Expanded professional networking, and career            X11    Super-Resolution Microscopy:                  Robert Sinclair, Stanford University
   development mentoring from recent graduates.                  Potential, Mechanics, Implementation,         Peter Crozier, Arizona State University
• Exposure to M&M vendors, and attendees affiliated              and Practicalities                            In situ and operando transmission electron
   with various societies represented at M&M.             LEAD INSTRUCTORS:                                    microscopy are becoming increasingly important
• The opportunity to win awards, determined by            Bryan Millis, Vanderbilt University                  in advanced materials characterization. Being
   peer voting.                                           Simon Watkins, University of Pittsburgh              able to observe materials in state that are similar
Visit https://microscopy.org/students/x60.cfm for         Super-resolution microscopy is becoming a            to real world applications is now recognize as
details, or email ellawren@asu.edu                        mainstream approach in both individual and           vital for relating structure to functionality. The
Check out the 2019 Preliminary Program at https://        core biomedical research laboratories. The           ability to perform atomic level analysis while
www.microscopy.org/MandM/2019/program/                    diversity and overall capabilities of these          the sample is exposed to different stimuli/
congress.cfm                                              techniques are evolving rapidly. As such, the        environments such as heat, strain, gas, liquids,
                                                          term “super-resolution microscopy” can describe      electric field, magnetic field, light, etc.…is a key
                                                          very different fundamental approaches, all           part of the in-situ approach. Operando approach
X61   NexTEM: Next-Generation Transmission
                                                          quite distinct with respect to implementation, and   require simultaneous measurement of some
      Electron Microscopy
                                                          each with specific strengths and weaknesses.         technologically relevant functionality such as
Sunday, August 4, 2019 l 8:30 AM - 5:00 PM                For the researcher looking to get into super-        current flow, deformation or catalysis.
Separate registration required.                           resolution microscopy, the aforementioned
                                                          can be overwhelming. This workshop primarily         X15    Data Analysis in Materials Science
INCLUDED IN REGISTRATION FEE:
Breakfast, AM Break, Lunch, PM Break                      attempts to clarify many of the questions that       INSTRUCTORS:
                                                          typically go along with getting started with         Duncan Johnstone, University of Cambridge,
ORGANIZERS:                                               super-resolution microscopy, as well as pairing        United Kingdom
Steven R. Spurgeon, Pacific Northwest                     the right technology with the biological             Katherine E. MacArthur, Forschungszentrum
 National Laboratory                                      question of interest.                                  Jülich, Germany
Mitra L. Taheri, Drexel University
                                                                                                               Magnus Nord, University of Antwerp, Belgium
Demie Kepaptsoglou, SuperSTEM, United Kingdom             X12    Selecting and Optimizing Image                Francisco de la Peña, University of Lille, France
Topics covered within this PMC include:                          Information in the SEM and VPSEM              Eric Prestat, University of Manchester,
• Integration of advanced instrumentation, in situ        LEAD INSTRUCTOR:                                       United Kingdom
  environments, and data analytics tools for more         Brendan Griffin, University of Queensland,           Joshua Taillon, National Institute of Standards
  comprehensive characterization of real-world            Australia                                              and Technology
  materials                                               Below-lens, through-lens and above-lens              This short course will introduce the use of
• Emerging instrumentation and approaches to              detection and imaging systems provide complex        HyperSpy and related Python libraries (atomap,
  examine nanoscale systems with high spatial             and exciting imaging options. For making the best    pixStem, pyXem) for analysis of microscopy
  resolution and chemical sensitivity                     choice, each will be explained and compared          datasets. No prior Python knowledge is required.
• Novel in situ and operando methods to study the         by means of a set of standard samples. This          Attendees will learn how to perform basic machine
  dynamics of complex materials systems, including        will include the effects of angular selectivity on   learning, multi-dimensional curve fitting for EELS
  alloys, thin films, nanoparticles, and liquids          annular backscattered-electron detection. Stage      and EDS quantification, atomic resolution image
• Machine learning and analytics approaches for           biasing, beam deceleration, stage isolation          analysis and big data processing (such as 4D
  high-throughput data collection, processing, and        and the effects of contact-protection systems        STEM) on desktop computers.
  feature classification
                                                                                                                        www.microscopy.org/MandM/2019
                                                                                                                                                           2019       5
Events and Activities Hosted and Organized by the
    Pacific Northwest Microscopy Society (Local Host Committee)
    Reservations Now Available! https://squareup.com/market/pacific-northwest-microscopy-society

                                                       This event is
                                                   made possible by the
                                                   generous support of
                                                   Stacie Kirsch at EMS
                                                   and Paul DeGeorge
                                                      at Marine Reef
                                                      International.

     Pub Crawl                                     Willamette River                                Portland
                                                   Dinner Cruise                                   Segway Tour
     Tuesday, August 6, 2019
     8:00–10:30 PM                                 Wednesday, August 7, 2019                       Discover Portland on a Segway!
     Meet at the Oregon Convention Center          7:00–9:30 PM
     (specific location TBA)
                                                                                                   Tuesday August 6, 2019
                                                   (6:30 PM boarding from the Salmon St./ Naito
                                                   Parkway embarkation in downtown Portland)       4:00–6:00 PM
     $6/person                                                                                     meet at Lovejoy Fountain Park
                                                   $45/person; $25 /person (students               (find it on Google Maps)
     Advance registration required!
                                                   only – will be verified)                        $30/person
     Join your PNMS host committee for an
                                                   Space is limited! Advance reservations
     evening of local beer and socializing. We                                                     Advance registration required
                                                   required!
     will visit 3 Portland breweries, all within                                                   (limited to 15 people)!
     walking distance of the Convention            Fresh Northwest cuisine, grand scenery
     Center, that serve a variety of beers from    and a warm summer evening are the main
     sours to stouts. Your first round is free!    ingredients for a memorable dinner cruise.
                                                   Join fellow M&M attendees for a chartered
                                                   2.5-hour dinner cruise aboard the Portland
                                                   Spirit (www.Portlandspirit.com), a 150’ yacht
                                                   with panoramic views from your climate-
                                                   controlled dining deck (exclusive to M&M)
                                                   and an upper observation deck. The cruise
                                                   will take you on a unique tour through
                                                   downtown Portland on the Willamette
                                                   River while you enjoy your meal. A full-
                                                   service cash bar provides wine and other
                                                   beverage service.

6         2019
                 August 4-8 | Portland, OR
Exhibit Hall
Open Monday, August 5 through Thursday, August 8
Oregon Convention Center, Halls B-C-D
Commercial Exhibits - The M&M exhibitor companies are an integral and exciting part of the meeting, showcasing
the latest in equipment and service offerings. To find out more about specific exhibitors, or to see a complete exhibitor
list, go to the Exhibits & Sponsors page at http://microscopy.org/MandM/2019/index.cfm

Vendor Tutorials – These popular events are arranged and produced by exhibiting companies at the end of the day
after the expo hall has closed. Exhibitors have the opportunity to demonstrate their products and equipment to a select
group of interested attendees. There is no cost to attendees, who can sign up onsite at the MSA MegaBooth.

Daily Coffee Breaks and Lunch Concessions – grab a hot or cold beverage, or something inexpensive to eat
while you visit the large exhibit hall each day.

Poster Presentations – Join the crowd for Poster Happy Hours, held daily Monday through Wednesday. Thursday’s
posters are presented along with a morning coffee break. All events are in the exhibit hall. Daily Student Poster Awards
are presented in the poster area.

MSA Megabooth – Visit the Megabooth for all things MSA! The Microscopy Society’s member center showcases
information on Membership, Outreach, Resources, Education, Publications, and more!

Plenary Speakers
The M&M 2019 Executive Program Committee is pleased to present two of the three 2017 Laureates of the
Nobel Prize in Chemistry “for developing cryo-electron microscopy for the high-resolution structure determination
of biomolecules in solution” and shared with Jacques Dubochet.

Joachim Frank, Ph.D.                                                           Richard Henderson, Ph.D.
Professor of Biochemistry, Molecular Biophysics, and                           Medical Research Council Laboratory of Molecular
Biological Sciences, Columbia University                                       Biology (MRC LMB) – Cambridge, United Kingdom

Single-Particle CryoEM: Information on                                         Single Particle CryoEM: Potential for
Structure and Motions of Macromolecules                                        Further Improvement
Dr. Joachim Frank’s major contribution to the field has                        Dr. Richard Henderson developed TEM into a
been developing mathematical and computational methods for                     tool for the direct determination of the structure
processing and analyzing cryo-EM images of multiple randomly-oriented          of proteins, and applied it most notably to two-dimensional (2D)
molecules within a sample and compiling them into a representative 3D          crystals of the purple light-harvesting protein, bacteriorhodopsin.
structure. Dr. Frank used his algorithms to generate the first 3D images       Images and electron diffraction patterns of many 2D crystals of
of the ribosome – a large structure made of several proteins and RNA           bacteriorhodopsin from multiple angles were acquired using low-
strands, which is responsible for translating RNA into proteins inside cells   dose electron exposures, and combined to generate a 3D image
in all organisms. With this distinctive technique, when combined with          of the protein. He continued to refine this technique over many
Dubochet’s method of ice-embedding, information on conformational              years until he produced images at similar resolutions as those
changes of macromolecules in their native states can be obtained,              from X-ray diffraction. Later, Dr. Henderson turned his attention
which enables a deeper understanding of the way ‘molecular machines’           to the development and improvement of methods of high-
function in cells. Structures of many molecules that resist crystallization    resolution electron cryo-microscopy and single particle structure
and hence cannot be studied by X-ray crystallography can now be                determination. With colleagues, he advanced these techniques
elucidated. Initially, the resolution that could be obtained was limited by    for exploring high resolution ultrastructure of membrane proteins,
the poor performance of recording media. This technical problem was            protein complexes and other non-crystalline biomolecules
solved 7 years ago with the introduction of cameras capable of detecting       in solution. During this journey, Dr. Henderson made critical
single electrons. The development of cryo-electron microscopy has              contributions to many of the single particle electron microscopy
revolutionized the imaging of biomolecules and propelled biochemistry          approaches, including pioneering the development of direct
into a new era. By now, about 1500 structures of proteins and RNA-protein      electron detectors.
complexes have been solved and entered in a public database, making
this knowledge a fast growing and increasingly important contribution to       Dr. Richard Henderson was presented with MSA’s Distinguished
molecular medicine and the development of drug therapies.                      Biological Scientist award in 2005, and was named as an MSA
                                                                               Fellow in 2009.
Dr. Frank’s achievements were recognized with MSA’s Distinguished Biological
Scientist award in 2003, and he was named an MSA Fellow in 2009.

                                                                                                             www.microscopy.org/MandM/2019
                                                                                                                                             2019    7
CALL FOR PAPERS

                                                         2019

2019 Exhibitors              (as of November 25, 2018)

Anton Paar USA                    Gatan, Inc.                       Protochips, Inc.

Angstrom Scientific Inc.          HIROX-USA, Inc.                   RMC Boeckeler
Barnett Technical Services        Hitachi High Technologies         Renishaw, Inc.

Bruker Corporation                Herzan, LLC                       Springer

Cambridge University Press        Integrated Dynamics Engineering   SPI Supplies

Direct Electron, LP               IXRF Systems, Inc.                Tousimis

Denton Vacuum, LLC                JEOL USA, Inc.                    Tescan USA

Duniway Stockroom Corp.           Leica Microsystems                Ted Pella, Inc.

EXpressLO, LLC                    Microscopy Innovations, LLC       Thermo Fisher Scientific

EMS/Diatome                       Oxford Instruments                Zeiss Microscopy

EDAX                              PNDetector GmbH                   XEI Scientific, Inc.

Fischione Instruments             PNSensor GmbH
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