PATHSENSE (Pathogen Sensing) - H2020 MSCA-ITN 2016
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PATHSENSE _ ETN
H2020 MSCA-ITN 2016
PATHSENSE
(Pathogen Sensing)
D8.2 Scientific Publications
Responsible partner: NUI Galway
Authors: Nina L Tuite and Conor O Byrne, National University of Ireland, Galway
Coordinator: Conor O Byrne, National University of Ireland, Galway.
Project website: www.pathsense.eu
Grant Agreement No.: 721456
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.2
D8.2 Scientific Publications PATHSENSE ETN
Project acronym PATHSENSE
Project full title Training Network to Understand and Exploit
Mechanisms of Sensory Perception in Bacteria
Grant Agreement no. 721456
Project start date 1-04-2017
Deliverable Title D8.2 Scientific Publications
Work Package Number WP 8
Work Package Title COMMUNICATION, DISSEMINATION, PUBLIC
ENGAGEMENT AND EXPLOITATION
Lead beneficiary NUI Galway
Author(s) NUI Galway
Date of Submission 29 March 2018
Dissemination level Public
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.3
D8.2 Scientific Publications PATHSENSE ETN
Table of Contents
Executive Summary ................................................................................................................... 4
PATHSENSE Background............................................................................................................ 4
1. PATHSENSE Scientific Publications ........................................................................................ 5
2. Conference Abstracts Submitted ........................................................................................... 5
2.1 European Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale,
Cork, Ireland. 23rd – 25th April 2018. ...................................................................................... 5
2.2 List_Maps Symposium EFB satellite meeting - International Symposium Foodborne
pathogens: from farm to pharmacy! Kinsale, Cork, Ireland. Thursday 26th April 2018. ...... 7
2.3 Annual Conference 2018 of the Association for General and Applied Microbiology ...... 8
3. Conclusion .............................................................................................................................. 8
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.4
D8.2 Scientific Publications PATHSENSE ETN
Executive Summary
Important objectives of the PATHSENSE Network are to ensure dissemination and exploitation of the
Networks activities and to promote public engagement and communication. Key to this is to develop
strategies to achieve optimum communication to different target audiences. These activities will be
managed through Work Package 8, led by NUI Galway.
The purpose of this document is to report on deliverable 8.2, ‘scientific publications’ during the first
12 months of the PATHSENSE project. At this stage a scientific journal or review article has yet to be
published. However, 22 abstracts have been submitted for conference poster presentations that will
take place in Month 13.
PATHSENSE Background
The PATHSENSE (Pathogen Sensing) ETN brings together an interdisciplinary team of world-leading
researchers from Europe to tackle a highly ambitious scientific project, focusing on the molecular
mechanisms of sensory perception in bacterial pathogens. PATHSENSE has established an innovative
doctoral training programme that will deliver 13 PhD graduates and high-impact scientific outputs.
The relationship between molecular structures and biological function is central to understanding any
living system; however the research methodologies required to unravel these relationships are often
complex and fast-changing.
The inter-sectoral team participating in this Network [8 leading Universities, 1 public research
institution, 4 companies (from spin-off to large multi-national) and 1 governmental agency] has the
infrastructure and track-record to train ESRs in these state-of-the art methodologies, including
structural biology, proteomics & protein biochemistry, molecular biology, bacterial genetics, food
microbiology, mathematical modelling, cell biology, microscopy and comparative genomics. The
project will involve extensive inter-sectoral mobility of the ESRs across 7 EU countries to make full use
of the complementary skills available at each of the hosting institutions. PATHSENSE will investigate
the poorly understood structure function relationships that exist within a large multi-protein complex
called a “stressosome”, which acts as a sensory organelle in bacteria.
A major objective of this Network will be to exploit the fundamental research to develop novel
antimicrobial treatments that have applications in the food and public health sectors. This project will
deliver high-impact science, 13 highly-trained innovative researchers and will produce a long-lasting
inter-sectoral network of collaborators who will continue to work together to exploit fundamental
research for the socio-economic benefit of Europe.
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.5
D8.2 Scientific Publications PATHSENSE ETN
1. PATHSENSE Scientific Publications
All 13 Early Stage Researchers for the PATHSENSE project were in place by December 2017. At this
Month 12 of the PATHSENSE programme, the ESRs are between 4 and 7 months into their first
academic year. During this time however, progress has been made towards achieving the projects
goals. So far however, the first scientific manuscript has yet to be prepared for publication.
Milestone 12 – Due Month 18 – (September 2018) ‘First research manuscript submitted for
publication’ – The Network is working towards achieving this milestone and will endeavour to reach it
on time.
2. Conference Abstracts Submitted
As part of the PATHSENSE dissemination plan, research findings will be communicated periodically at
international conferences. The Early Stage Researchers are preparing to present their research at
poster presentation sessions at a conference and a satellite symposium in Cork, Ireland in April of this
year as shown below. ESR6 has also been accepted to attend and present at an additional meeting in
Germany, also shown below.
2.1 European Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale,
Cork, Ireland. 23rd – 25th April 2018.
This conference will gather scientists working in fundamental and applied research and interested in
understanding how microorganisms cope with stress. The meeting welcomes microbiologists,
biotechnologists, system biologists, biochemists and molecular biologist from both academia and
industrial sectors: http://www.efbiotechnology.org/microbialstress/
11 of the individual research projects will be presented at this conference in April 2018. Below lists
the abstracts that have been accepted by the organisers for presentation.
Titles of abstracts submitted to the upcoming European Federation of Biotechnology (EFB) 4th
Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Manisha Pandey and Nicola Stanley-Wall. Genetic study of the molecular mechanisms of sensory
perception in Bacillus subtilis. European Federation of Biotechnology (EFB) 4th Microbial Stress
meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.6
D8.2 Scientific Publications PATHSENSE ETN
Charlotte Dessaux, M. Graciela Pucciarelli and Francisco García-del Portillo. Detecting Listeria
monocytogenes stressosome proteins in response to stress. European Federation of Biotechnology
(EFB) 4th Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Laura Cutugno, Maria Conway, Jan Pané-Farré and Aoife Boyd. Genetic characterisation of the Vibrio
vulnificus stressosome and its role in virulence. European Federation of Biotechnology (EFB) 4th
Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Maria Conway, Kristina Wickes, Laura Cutugno, Sema Ejder, Algirdas Mikšys, Aoife Boyd, Christina
Ziegler, Rick Lewis, Jon Marles-Wright, Mareike Fischer and Jan Pané-Farré. Phylogenetic distribution
of RsbR orthologs and sequence conservation in stressosome proteins and their putative output
modules. European Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale, Cork,
Ireland. 23rd – 25th April 2018.
Inge van Vilsteren and Nicholas Brian Johnson. Influence of osmotic stress on heat resistance in food
products. European Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale, Cork,
Ireland. 23rd – 25th April 2018.
KahYen C. Yeak, Jos Boekhorst, Tjakko Abee, Marjon H.J. Wells-Bennik. Distribution of Sigma B
stressosome and RsbK signalling pathways and predicted regulons in the genus Bacillus. European
Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th
April 2018.
E. Ivanova Stojcheva, E. de la Fuente, F. García-del Portillo and J.C. Quintela. Antilisterial activity
of selected plant extracts in unstressed conditions and in combination with sublethal stresses
of pH, temperature and NaCl. European Federation of Biotechnology (EFB) 4th Microbial Stress
meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Algirdas Miksys, Veronika Heinz, M. Gregor Madej, Susann Kaltwasser, Jan Pané-Farré, Maria Conway,
Rick Lewis, Jon Marles-Wright and Christine Ziegler. Investigation of symmetry breaks in the assembly
of the stress-sensing stressosome complexes of L. monocytogenes and V. vulfnificus by cryo-EM.
European Federation of Biotechnology (EFB) 4th Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd
– 25th April 2018.
Sema Ejder, Jon Marles-Wright and Rick Lewis. Structure-function relationships of the stress sensory
domains in the Listeria monocytogenes stressosome. European Federation of Biotechnology (EFB) 4th
Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Ana Oliveira, Teresa Tiensuu, and Jörgen Johansson. The role of RsbX in the stressosome sensory
system of Listeria monocytogenes. European Federation of Biotechnology (EFB) 4th Microbial Stress
meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
Duarte Guerreiro and Conor O’Byrne. Genetic and phenotypic characterization of the sensory
proteins in the Listeria monocytogenes stressosome. European Federation of Biotechnology (EFB)
4th Microbial Stress meeting, Kinsale, Cork, Ireland. 23rd – 25th April 2018.
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.7
D8.2 Scientific Publications PATHSENSE ETN
2.2 List_Maps Symposium EFB satellite meeting - International Symposium Foodborne
pathogens: from farm to pharmacy! Kinsale, Cork, Ireland. Thursday 26th April 2018.
This symposium is organized by the H2020 funded MSCA project List_MAPS GA no. 649184
http://blog.u-bourgogne.fr/list-maps/conference/.
12 of the PATHSENSE Early Stage Researchers will present their research at this event. Below lists the
abstracts that have been accepted by the organisers for presentation at the List_Maps Symposium.
Titles of abstracts submitted to the upcoming List_Maps Symposium EFB satellite meeting -
International Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Manisha Pandey and Nicola Stanley-Wall. Genetic study of the molecular mechanisms of sensory
perception in Bacillus subtilis. List_Maps Symposium EFB satellite meeting - International Symposium
Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Charlotte Dessaux, M. Graciela Pucciarelli and Francisco García-del Portillo. Detecting Listeria
monocytogenes stressosome proteins in response to stress. List_Maps Symposium EFB satellite
meeting - International Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Laura Cutugno, Maria Conway, Jan Pané-Farré and Aoife Boyd. Genetic characterisation of the Vibrio
vulnificus stressosome and its role in virulence. List_Maps Symposium EFB satellite meeting -
International Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Maria Conway, Kristina Wickes, Laura Cutugno, Sema Ejder, Algirdas Mikšys, Aoife Boyd, Christina
Ziegler, Rick Lewis, Jon Marles-Wright, Mareike Fischer and Jan Pané-Farré. Phylogenetic distribution
of RsbR orthologs and sequence conservation in stressosome proteins and their putative output
modules. List_Maps Symposium EFB satellite meeting - International Symposium Foodborne
pathogens: from farm to pharmacy! 26th April 2018.
Inge van Vilsteren and Nicholas Brian Johnson. Influence of osmotic stress on heat resistance in food
products. List_Maps Symposium EFB satellite meeting - International Symposium Foodborne
pathogens: from farm to pharmacy! 26th April 2018.
KahYen C. Yeak, Jos Boekhorst, Tjakko Abee, Marjon H.J. Wells-Bennik. Distribution of Sigma B
stressosome and RsbK signalling pathways and predicted regulons in the genus Bacillus. List_Maps
Symposium EFB satellite meeting - International Symposium Foodborne pathogens: from farm to
pharmacy! 26th April 2018.
E. Ivanova Stojcheva, E. de la Fuente, F. García-del Portillo and J.C. Quintela. Antilisterial activity
of selected plant extracts in unstressed conditions and in combination with sublethal stresses
of pH, temperature and NaCl. List_Maps Symposium EFB satellite meeting - International Symposium
Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Algirdas Miksys, Veronika Heinz, M. Gregor Madej, Susann Kaltwasser, Jan Pané-Farré, Maria Conway,
Rick Lewis, Jon Marles-Wright and Christine Ziegler. Investigation of symmetry breaks in the assembly
of the stress-sensing stressosome complexes of L. monocytogenes and V. vulfnificus by cryo-EM.
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.8
D8.2 Scientific Publications PATHSENSE ETN
List_Maps Symposium EFB satellite meeting - International Symposium Foodborne pathogens: from
farm to pharmacy! 26th April 2018.
Sema Ejder, Jon Marles-Wright and Rick Lewis. Structure-function relationships of the stress sensory
domains in the Listeria monocytogenes stressosome. List_Maps Symposium EFB satellite meeting -
International Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Ana Oliveira, Teresa Tiensuu, and Jörgen Johansson. The role of RsbX in the stressosome sensory
system of Listeria monocytogenes. List_Maps Symposium EFB satellite meeting - International
Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Duarte Guerreiro and Conor O’Byrne. Genetic and phenotypic characterization of the sensory
proteins in the Listeria monocytogenes stressosome. List_Maps Symposium EFB satellite meeting -
International Symposium Foodborne pathogens: from farm to pharmacy! 26th April 2018.
Torkel Loman and James Locke. Mathematical Modelling as a Tool to investigate environmental
stress response in B. Subtilis. List_Maps Symposium EFB satellite meeting - International Symposium
Foodborne pathogens: from farm to pharmacy! 26th April 2018.
2.3 Annual Conference 2018 of the Association for General and Applied Microbiology
Translates as:
VAAM Jahrestagung 2018 [der Vereinigung für Allgemeine und Angewandte Mikrobiologie]
Wolfsburg, Germany. 15 – 18 April 2018
Maria Conway, Kristina Wicke, Algirdas Mikšys, Sema Ejder, Laura Cutugno, Mareike Fischer, Aoife
Boyd, Christine Ziegler, Jon MarlesWright, Rick Lewis, Katharina Riedel, Jan Pané-Farré. Phylogenetic
distribution of RsbR orthologs and sequence conservation in stressosome proteins and their
putative output modules. der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM)
Wolfsburg, Germany. 15 – 18 April 2018.
3. Conclusion
The Network will continue to drive the dissemination plan and to strive to achieve the objectives of
Work Package 8. The PATHSENSE ESRs are at an early stage of their first academic year yet 22 poster
presentation abstracts have been accepted for presentation at various events in Month 13.
“This project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No 721456”.You can also read
