What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution

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What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution
What’s the market
pull for E-Health?
Presentation at 9th Berlin
Conference on IP in Life
Sciences – Digital Health
Solution

12th February 2016
What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution
There is clearly a market pull towards digitalization, across industry
and in healthcare
Digitalization is disrupting traditional industries…   …and creates strong pull in
                                                       healthcare

                                                                                                        233.3

                                                                                 +21%

                                                                                 135.9
                                                                                                        233.3
                                                             73.2
                                                                                 135.9
                                                             73.2

                                                            2014                  2017                   2020
                                                            Digital health market [bn USD]

Source: Roland Berger team analysis                                       What’s the market pull for E-Health.pptx   2
What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution
Across industries, a technological and a sociological revolution are
under way
Trend overview

A TECHNOLOGICAL                                                                            A SOCIOLOGICAL
REVOLUTION                                                                                     REVOLUTION

   TECHNOLOGY ADVANCES                                                             CONSUMER/PATIENT
                                                                                   BEHAVIOR CHANGES
   > The world is connected via
     the internet                             DIGITAL                              > Consumers/patients have
                                                                                     increasing access to transparent
   > Powerful computing & communication
     devices are increasingly mobile      TRANSFORMATION                             information
                                                                                   > The 'informed patient' is
                                                                                     transforming to the 'participating
                                                                                     patient'

  DATA VOLUME                             BIG DATA CHANGES
                                                                                   START-UP ACTIVITIES
  INCREASES                               TRADITIONAL BUSINESS
                                                                                   INCREASE
  > More and more digital data is         > Existing businesses must identify
    generated                               the value of data for their industry   > VCs believe in business
                                            if they want to be sustainable in        models that are designed
  > The belief in mutual enrichment by
                                            the future                               for this new environment
    exchange fuels data sharing

Source: Roland Berger                                                                        What’s the market pull for E-Health.pptx   3
What's the market pull for E-Health? - Presentation at 9th Berlin Conference on IP in Life Sciences - Digital Health Solution
The major challenge in modern medicine is the interpretation of
enormous amounts of data within human biological networks
Holistic approach to studying complex biological systems
Multi-Omics                         Complexity and variability of humans         Systems medicine

                                                                                 > Systems medicine evolved from systems biology
                                                                                   – Systems biology is the study of systems of
                                                                                     biological components, which may be
                                     Organisms            Populations                molecules, cells, organisms or entire species
                                                            …
                                                                                   – Systems biology is pioneering actionable
                                                                                     understandings of disease and wellness as a
                                                                                     continuum of network states unique in time
                                     Organs                 50 organs                and space to each individual human being
Microbiome
                                                            100 trillion cells   > Systems medicine aims at better understanding
Cytome
                                     Cells                                         processes within the human body at molecular
Metabolome                                                                         level and its interactions
                                                            20,000 proteins
Proteome                                                                         > The major challenge for systems medicine is to
                                     Molecules                                     find the significant signals within this enormous
Transciptome                                                35,000 orfs
Epigenome                                                                          amount of individual data and enhance the signal-
Genome
                                                            6 bn nucleotides       to-noise ratio
                                     Genes

Source: Hood and Flores; Naylor and Chen; Roland Berger                                                    What’s the market pull for E-Health.pptx   4
In our view, winning Digital Health offerings must fulfill a clear set of
principles to make it attractive
Principles of winning Digital Health offerings
                                               Follow customer journeys – target specific interactions in the healthcare system
                               Interaction
                                               Connect all stakeholders across the healthcare system

                                               Overcome disconnect between healthcare provider and patient
                              Value-added
                                               Use smart solutions, offer tangible value added: time, money, quality, outcomes

                               Platform/       Get the initial patient connection right - ubiquitous digital channels: Social media, website, apps
                               connectivity     as touch points (mobile network of connectivity)

                                               Take advantage of comprehensive user data
                                  Data
                                               Ensure accessibility and security
e-Health                                       Gather meaningful insights
                              Intelligence
Offering                                       Use Big Data to become predictive, not reactive

                                               Use multiple interfaces to suit the patients‘ lifestyle
                                 Device
                                               Link with technology standards and build closed loop system

                                               Give precise measurements
                                Sensor
                                               Considers patient convenience with e.g. wearable sensors

                                               Add new technology dimension to core product
                             Pharmaceutical
                                               Enhance value proposition beyond the molecule

                                               Reflect regulatory & care environment
                                Regional
                                               Understand and accept local pain points – adjust technology and value added

Source: Roland Berger Team                                                                                    What’s the market pull for E-Health.pptx   5
Market pull is mainly driven by new entrants, consumers,
insurances, government and industry – players move to the right
Market pull of selected healthcare players – European perspective

                                                 Pharmacy                              Pharma
Healthcare                                       • Reluctant since                     • Opportunities across
Industry                                           – fear of e-prescriptions             the value chain             Medtech               New entrants
                                                   – investment needed                 • Different priorities        • Some segments • Development of new
                                                 • Some see opportunity to                                             shape digitalization business models and
                                                   drive compliance/ adherence                                         more than others     partnerships
                                                                                           Government
                                                                                           • Embraces                            Patients/ Consumers
Public sector                                                                                                                    • Hybrids with increasing
                                                                                             opportunities to
                                                                                             increase transparency                 digital habits
                                                                                             and efficiency                      • Information needs
                                                                                                                                 Statutory insurances
Payer                                                                                                                            • Strong interest in
                                                                                  Private insurances                               transparent information
organizations                                                                                                                      and improved patient
                                                                                  • Positive but cautious
                                                                                  • Limited market power                           care at lower cost
                                 Office based physicians
                                 • Doubts concerning                 Public
                                                                                                            Private Providers
                                   – patient/ doctor relation        Providers
Care provider                                                        • Reluctant concerning
                                                                                                            • Promising potential
                                   – data security/ protection                                                to improve patient pathways
                                   – medical independence              investment needs
                                                                                                              and efficiencies

                                        Reluctant                                   Neutral                                      Pushing
                                                                             Attitude towards e-Health

Source: Roland Berger Analysis                                                                                             What’s the market pull for E-Health.pptx   6
Industrial healthcare players identifying opportunities across the
    value chain
    Industrial value chain
                        Smart data           Industry 4.0      Digital health      Multichannel management

 Pharma                                    Manufacturing /        Medical /
Company                     R&D                                                                    Sales
                                            Supply chain          Marketing

                                       Industry 4.0               Digital health
 Digital
  tool                                                                           Multichannel management

                              Smart data

              > Biotech > KOLs         > Suppliers           > Physicians > Hospitals   > Consumer > Payers
Target        > Clinical > Patients    > Technical service   > Payers     > Patient     > Patient > Hospitals
groups          centers                  providers             groups     > KOLs        > Pharmacies
              > Diagnostics                                  > Consumers

    Source: Roland Berger                                                                What’s the market pull for E-Health.pptx   7
R&D

Roche decided to exploit the market potential stemming from
digitalization mainly in the R&D area

Roche's strategic transaction regarding Foundation Medicine                          R&D approach
                                                                                      > Focus of the R&D collaboration will
                                                                                        be on developing genomic profile
                                                                                        tests for cancer immunotherapies
                                                                                        and for continuous blood-based
                                                                                        monitoring
                                                                                      > Roche will be able to utilize FMI’s
  > In 2015, Roche acquired a majority stake in Foundation Medicine, a new player       proprietary molecular information
    in the field of molecular information in oncology                                   platform to standardize clinical trial
  > FMI supports physicians by providing comprehensive molecular information to         testing
    characterize a tumor that is being matched with approved targeted therapy         > Roche aims for comparability of
    options and novel treatments under development                                      clinical trial results for R&D
  > Collaboration leverages both companies’ strengths to advance the progress of        purposes to improve decision
    personalized treatments for patients with cancer                                    making and support optimization of
                                                                                        patient care as oncology
  > The partnership includes both a broad R&D collaboration with the potential for      management becomes more
    more than USD 150 million funding by Roche to accelerate FMI’s new product          complex
    development as well as commercial collaboration agreements aimed at
    expanding the global sales efforts for FMI’s current and future products          > Digitalization will further link R&D
                                                                                        with real life treatment data

Source: Roland Berger, Roche press releases                                                       What’s the market pull for E-Health.pptx   8
Mfg. / Supply chain

New technologies have the potential to disrupt the Medtech and
Pharma manufacturing world
Selected Industry 4.0 technologies and use cases
Virtual Manufacturing               Additive Manufacturing           Predictive maintenance           Cyber physical systems

> 3D CT data and the NX-            > In March of 2015, 3D           > ThyssenKrupp uses Microsoft    > On the assembly line at the
  CAD/CAM software from               Bioprinting Solutions became     predictive analytics             Bosch Rexroth plant
  Siemens PLM enable                  the first group to               software for its elevator        Homburg / Saar, an RFID
  simulation and design of            successfully bioprint and        maintenance support              chip on the work piece
  customized and patient-             transplant a thyroid gland     > Elevators are connected to a     steers its own production
  specific artificial joints with     for a mouse                      cloud and transfer data from     steps through nine intelligent
  still a high degree of process                                       sensors to the system for        work stations
  chain automation                                                     predictive and even            > Displays show the employees
                                                                       preemptive maintenance           the appropriate work
                                                                                                        instructions

Source: Roland Berger analysis                                                                          What’s the market pull for E-Health.pptx   9
Medical / Marketing

Digital offerings are manifold and will change the way how people
are treated tremendously – Pharma’s offerings will be impacted

                                    Bayer
Apple Health                        BETACONNECT™                    23 and me                         Proteus digital

> Currently focuses on              > Prescribes injection          > FDA and CE approval             > Available in the USA
  collection of health and            reminders, injection depth    > DNA analyzer that enables       > Marketed as an intelligent
  fitness information from third-     and speed based on patient      users to learn about and          medicine platform integrating
  party apps                          preferences                     explore their DNA                 patients, patients’ relatives
> Glucose monitor in                > Stores and shares injection   > Extrapolates ancestry reports     and treating doctors
  development using non-              information (date, speed,       and raw data from its           > Includes wearable and
  invasive sensors                    volume) and symptoms and        database                          ingestible sensors
> Takes advantage of                  syncs live with smartphone
                                      app                           > Future use for health-related   > Developed in cooperation
  pedometer, blood pressure,                                          genetic information               with Novartis and Otsuka
  hydration and heart rate          > Shares the data with            anticipated                       Pharmaceuticals
  screening                           healthcare providers via an
                                      online dashboard                                                > FDA application for first
                                                                                                        drug/device combination
                                    > FDA approval in 09/2015                                           (ABILIFY) ongoing

Source: Roland Berger                                                                                   What’s the market pull for E-Health.pptx   10
Sales

Digitalization within healthcare sector gives birth to new business
models enabling self-monitoring, higher efficiency & convenience
Major Digital Health trends
               Quantified health                                         Tele-health                                         Medication online

e.ventures "Wearables becoming                                           "Extending the                                       "Pharmacy reinvented"
says:            smarter"                                                 point of care"

> Tracking of physical activity and other               > Telemedicine services connecting patients                > Simplified process of getting
  health indicators due to rise of wearable               directly with doctors via video allow for                  prescriptions or receiving medication
  technologies and sensors                                higher convenience at lower costs                          through faster submission technologies
> Features of new devices going beyond fit-             > Monitoring of at-risk patients simplified
  ness and are more sophisticated than ever               especially in the field of chronic diseases
                           Record memories
                           on the go                                                 Online connection
                                                                                     to your doctor

                                                                                                                      Online pharmacy
  Activity & diet                   Fitness & sports
  tracking                                                    Tele-health platform connecting doctors & patients
                                    activity tracking

Source: e.ventures; Roland Berger                                                                                                  What’s the market pull for E-Health.pptx   11
So for moving forward – what are the guiding questions to be
answered?

  What are the drivers and hurdles for digital transformation of Pharma and
  Healthcare and how does it change the paradigm in modern medicine?

  Where is the potential of the new paradigm in modern medicine and how can
  digital transformation help unlock this potential?

  Which new business models emerge from the associated digital
  transformation?

  How can the opportunities arising from digital transformation in pharma and
  healthcare be addressed?

                                                                   What’s the market pull for E-Health.pptx   12
Strategic collaboration will become more important than ever for
established players to succeed in the new business environment
Conclusion

Challenges              > Implement out-of-the-box innovation
                          into a highly regulated environment
                        > Combine development cycles and
                          know-how from IT and medicine
                        > Open up for partnerships              Strategic cooperation to face
                        > Achieve quick wins to keep going      new business reality
                                                                > Pharma
Exemplary partnerships and initiatives of                       > Medtech
established Pharma players with other industries
                                                                > IT
                        > Google and Sanofi collaborate in      > Consumer industries
                          Diabetes Care
                                                                > Telecommunications
                        > Roche acquires Big Data platform
                          Bina Technologies for next
                          generation sequencing

Source: Roland Berger                                                              What’s the market pull for E-Health.pptx   13
On our first "Digital Health Day" on February 25th at spielfeld we are
connecting industry leaders with promising start-ups

"Digital Hub" in Berlin                                        Digital Health Day
       Strong network of digital-    Several top-companies     > Senior executives will meet innovative
       /tech-partners and start-     working on digital
       ups                           projects, curated by RB     start-ups to discuss disruptive and
                                                                 successful business models
       1,000m2 multi-functional
                                     Digital Academy           > Clients will have the opportunity to
       space
                                                                 develop own ideas through an idea
       Broad portfolio of services                               generation workshop, and to develop
       from inspiration formats to
                                     Big/Smart Data Lab          and implement concepts in follow-on
       prototyping and change
       projects                                                  projects
                                                               > Selected participants:

Source: Roland Berger                                                                    What’s the market pull for E-Health.pptx   14
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