2018 Grant Instructions & Policies - Tapez ici - ELA international
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2018 Grant Instructions & Policies [Tapez ici]
A. INSTRUCTIONS
I. SCOPE of RESEARCH II. PREPARING YOUR APPLICATION
Before starting to work on your application, please The submission of applications shall be done online
make sure the scope of your research project fits at http://elainternational.eu/site/en/ao-prive. Prepare
with the topics required by ELA International: the application by filling up all the sections.
Read and follow the instructions carefully.
ELA International represents national ELA The document must be filled out in English ONLY
associations from different countries that contribute and must comply with the format specifications and
together to the financing of research on page limits detailed in this document. Do not
leukodystrophies. It is run by parents and /or reformat the forms or exceed the space provided in
patients affected by leukodystrophies. Accordingly, the different sections of the grant application.
ELA International wishes to focus funding on Failure to comply will result in administrative
programs devoted to the improvement of the health withdrawal. Decisions of administrative withdrawal
and welfare of patients. This objective can be are final and not subject to appeal.
achieved through studies aimed at understanding
disease mechanisms, developing natural history A. GENERAL INSTRUCTIONS
studies including outcome measures and Most of the sections in the online application are
biomarkers, and conducting clinical trials. self-explanatory.
Warning, PLEASE READ
Themes proposed in the 2018 call for proposals will • Your application must be submitted online • All
focus on unmet needs in the field of mandatory fields must be completed. • If non
leukodystrophies. applicable, indicate N/A in the field, not to leave it
empty.
Research Topics of Interest include: • Attention: you must save your data before
leaving a page
• Clinical trial / clinical trial readiness for • You can save a draft of your application and
leukodystrophies including the development update it until its final validation.
of longitudinal outcome measures, • Once your application is validated, you will not be
biomarker characterization, imaging able to modify it and your login will be disabled.
modalities and pharmacodynamics • If absolutely necessary, you will have the option to
/pharmacokinetic studies.
address a modification request to elise.vivar@ela-
• Preclinical studies specifically testing
therapies (gene, cell, enzyme or asso.com. Indicate “Call for proposals –
pharmacologic therapies) for modification request” in the subject of your email.
leukodystrophies. • After validation of the online form, the pages
• Developing animal or cell-based models requiring a signature and/or a stamp of your
(e.g. patient derived iPSC) relevant to institution will need to be printed, completed and
human leukodystrophies. sent to ELA office (ELA - Pôle recherche - 14 rue
• Study of mechanisms responsible for La Fayette - 75009 Paris France). These signature
leukodystrophies, in order to identify new fields will only be accessible on the printed version.
therapeutic approaches. • Your login will be valid until the end of the call for
proposals.
Studies should address a knowledge gap in the
field of leukodystrophies and a preference will be Choose the form to fill
given to clinical trials and clinical trial readiness for A Grant Application or Research Fellowship
leukodystrophies. Translational studies using Application can be submitted. Select the
animal models should use genetic models of appropriate value. Attention to select carefully, this
leukodystrophies. Novel gene discovery studies fall choice cannot be modified once confirmed.
outside of this funding opportunity. Joint funding Grant Application
initiatives for clinical trials are encouraged. Select the appropriate values between Individual
project and collaborative project involving 2 or 3
Direct costs cannot exceed 100,000 per year, for a teams. Indicate if the project is a pilot project.
maximum funding period of two years.
2018 ELA Grant Instructions & Policies Page 2/9RESEARCH GRANT APPLICATION the potential impact of your project to advance
Eligibility: The Principal Investigator and co- research on leukodystrophies towards the
investigators must have a faculty appointment development of therapies.
(position equivalent to assistant professor or higher) Personnel involved in the project
in order to be eligible for a grant from ELA List all personnel, including names, degrees,
International. birthdate, institution, % effort and detailed roles on
the project.
Collaborative Projects Recommended format: John Doe, M.D.,
The Principal Investigator of a collaborative project 23.04.1967, Principal Investigator, UCLA (Effort:
will be the contact and manager of the project. 30%), will be responsible for the construction of
Therefore, its name should be entered in the Team PLP-GFP mutants and…
A section. Team A represents the principal
Publications
investigator’s team.
List the 3 main articles published by the principal
Grant Application and Research Fellowship investigator related to this proposal.
A research project/fellowship can be funded for a
maximum of two years. Type the appropriate value: FELLOWSHIP
1 year or 2 years. Pilot projects can only be funded References
for a year. Name three references that are or have been
Select the Research topic of interest addressed by associated with the applicant and that know him/her
your proposal. well. Choose referents primarily outside the
Attention to select carefully, this choice cannot be applicant’s current institution.
modified once confirmed. The format of the
application cannot be modified later on. Research Plan
Enter the text online or upload a 10 pages pdf
B. SPECIFIC INSTRUCTIONS (respecting the format). If you want to paste text
You can now access the sections to be completed. from a Word document, please use the icon "Paste
Either all the sections, or a selection of sections from Word" to keep the layout.
related to the budget, the science or the teams. Page limitations
Click on “ALL”, “Budget”, “Science”, or the “Team” Do not exceed 10 pages. All tables, charts, graphs,
of your choice to access the list of items. figures, diagrams, images, photographs, and
Each section will open a page to be completed. references must be included within the 10-pages
Attention: Remember to save your data before limit.
leaving a page. Unsaved data will be lost. Once
Font
a section is complete, a check mark will be visible in
For the research plan, use Arial font size 11 point.
front of the corresponding line in the general menu.
Greeks letter are allowed. Same font size applies.
Executive Summary Figures
Amount Requested (€) Figures, graphs, charts, tables and figure legends
Warning: The amount in Euros listed as “Amount may be small in size but must be clear and legible.
Requested (€)” representing the contribution Photographs and images must be a part of the
requested to ELA for the entire project will be electronic application file and cannot be sent
automatically calculated once the detailed budget separately.
tables are completed. No applicant should have an advantage over other
Abstract (less than 500 words) applicants by providing more content in his/her
State the general interest of the project, the application by using smaller, denser type.
application’s objectives and specific aims. Describe If terms are not universally known spell out the term
concisely the research design and methods for for the first time it is used and note the appropriate
achieving the stated goals. Describe the rationale abbreviation in parentheses. The abbreviation may
and techniques you will use to pursue these goals. be used thereafter.
Clearly describe the expected results and the
relevance to health and therapy for Structure of the research plan
leukodystrophies. Do not exceed the space A. Specific Aims
provided. List the broad, long-term objectives and the goal of
Rationale the specific research proposed and the rationale.
Describe in less than 500 words the novelty of your B. Background and Significance
Briefly sketch the background leading to the present
project, its relevance with regards to the topics of
application, critically evaluate existing knowledge,
the 2017 call for proposals of ELA International and
2018 ELA Grant Instructions & Policies Page 3/9and specifically identify the gaps that the project is Peer-reviewed publications
intended to fill. List your most significant peer-reviewed
C. Preliminary studies publications in the last five years in chronological
Provide the preliminary studies pertinent to this order starting from the most recent ones. Include
application. accepted manuscripts in press but omit manuscripts
D. Research Design & Methods submitted or in preparation. Follow the following
Describe the research design, procedures, and format: Authors’ names, Title, Journal, Year,
analyses to be used to accomplish the specific aims Volume, Pages and mark the publications obtained
of the project. Indicate how the data will be with ELA funds with an asterisk.
collected, analyzed, and interpreted. Describe any
new methodology, novel concepts, approaches, For Fellows only
tools, or technologies and their advantages over List active, approved, completed and pending
existing ones. fellowships for the last three years using the
Describe the expected results for each aim and following sample:
discuss the potential difficulties and limitations of
the proposed procedures and alternative Project number: ………………………………..
approaches to achieve the aims. State concisely Start date – End date: ……………………………..
the importance and health relevance of the % Effort: ……………………………..
research described in this application by relating the Funding Organization: ……………………………..
specific aims to the broad, long-term objectives. If Award amount: ……………………………..
the aims of the application are achieved, state how Title of the project: ……………………………..
scientific knowledge or clinical practice will be Goals of the project: ……………………………..
advanced in the field of leukodystrophies. In case of Overlap (justify): ……………………………..
a human/clinical study, describe the ethical aspects For pending applications, precise when answers
of the project. are expected.
E. Timeline
Provide the planned milestones by year (and by
team in case of collaborative projects) for the entire For Research Grant Applications
project. Personnel’s Biographical Sketch
A one-page personnel’s biographical sketch is
For Collaborative Projects required for all individuals listed in the Personnel
F. Leadership plan Form(s) to be funded by ELA but the principal
A rationale for choosing a multiple PI approach investigator and co-investigator(s) (if applicable).
should be described. The roles and administrative, Describe education, positions and list publications
technical, and scientific responsibilities for the of the last 3 years.
project should be delineated for the PI and co-
Collaborative Projects: Each team has to provide
investigators.
personnel’s biographical sketches for the personnel
to be funded by ELA.
G. Literature Cited
List all references. It is important to be concise and Budget Forms
to select only the references pertinent to the Use ONLY the Euro currency in these tables.
proposed research. Notes:
Follow the following format: Authors’ names, Title, The maximum budget requested to ELA cannot
Journal, Year, Volume, Pages. If a publication be higher than 100.000 € per year.
contains more than 10 authors, just list the first 3 ELA International neither covers overhead/
authors. indirect costs, nor salaries for principal
PI/Co-Investigator/Fellow/Supervisor Bio Sketch investigators, co-investigators and scientists
Form (2 pages max) with permanent or tenure-track positions.
Education, Training, Positions and Honors
List in chronological order your education, training, Personnel
current and previous positions, starting with your ELA-funded personnel
present position. Include start/end dates, position Salaries for Ph.D. students and postdoctoral fellows
title, name of organization and department. In case or other personnel must match the salary grid of the
of non-permanent/non tenure or fixed term position, applicant’s country. The corresponding grid needs
state the term of the current contract. to be submitted by the applicant. The annual base
Select and list professional memberships and salary represents the salary for a period of 12
academic/professional honors received. months.
2018 ELA Grant Instructions & Policies Page 4/9Enter the name, annual salary base and fringe Lay Summary
benefits of the personnel to be funded by ELA. Describe in a plain, lay language the aims of your
Enter the % of time dedicated to the project effort research project, the means to be used to test your
and the total annual salary requested to ELA. hypotheses and the relevance to health & therapy
Fringe benefits are supported by ELA International for leukodystrophies. Do not exceed the space
and are required for all personnel including Ph.D. provided.
students and postdoctoral fellows. If the application is awarded, the lay summary will
become public information. Therefore, do not
FELLOWSHIP include proprietary/confidential information.
Only Personnel funding can be requested for ONE Research Support
fellow to ELA. No funding can be asked for List active, approved, completed and pending grant
Supplies, Equipment and Travel. supports for the last three years using the following
sample:
Non-ELA funded personnel
List the salaries of all personnel participating to the Project number: ………………………………..
project whose salaries will be covered by other Start date – End date: ……………………………..
means. % Effort: ……………………………..
Equipment Funding Organization: ……………………………..
ELA will participate to the cost of old/new Award amount: ……………………………..
equipment required for the conduct of the project, in Title of the project: ……………………………..
the limit of expenses related to the project. Goals of the project: ……………………………..
Overlap (justify): ……………………………..
For pending applications, precise when answers
Global Budget Justification Form
are expected
Personnel
List all personnel and their detailed roles on the APPENDIX MATERIAL
project. No individual salary information should be Manuscripts accepted for publication but not yet
provided here. published must be submitted (along with the
Supplies acceptation letter) as PDF files. Do not include
Itemize supplies by year in separate categories manuscripts submitted for publication or in
such as glassware, chemicals, radioisotopes, etc… preparation.
and justify their use. If animals are to be purchased, For applications developing clinical trials, the full
state the species and the number to be used. Each protocol, budget of the trial and IRB approval are
category must be accompanied with the required.
corresponding amount of money requested. Each Internet addresses may not be used to provide
yearly amount for supplies must match the amount additional information.
listed in Budget Forms. Do not attach any documents other than those
Equipment specifically requested.
List each item of equipment by year, justify their use
and fill out the provided table documenting the FELLOWSHIP
amount corresponding to the expenses related to Include a letter of recommendation from the
the project. supervisor. This letter should describe the ability of
The total annual amount must match the amount the supervisor as a mentor, the funds available to
listed in Budget Forms. the applicant from the supervisor for the project’s
Provide the company’s estimate for new equipment supplies, equipment and travel (if applicable). It
costing more than 4 000 € (not applicable for should also provide an assessment of the applicant,
fellowship applications). describe the relationship of the proposed project to
ongoing research in the supervisor’s lab, describe
Travel
the supervisor’s plan to develop the applicant’s
Travel can only be requested to cover meetings
research capabilities, describe the relationship of
between partners of a collaborative project. No
the research training with the applicant career goals
travel can be asked for individual projects or
and clarify the role the fellow played in the
fellowships. Travel to scientific congresses is not
development of the research proposal.
eligible for funding. Specify for each year the trip
Include a cover letter documenting the fellowship
destination and names of individuals. The travel
application title. The letter must describe the
amounts must match the amounts listed in Budget
fellow’s career goals.
Forms.
2018 ELA Grant Instructions & Policies Page 5/9SUBMITTING YOUR APPLICATION Acknowledgment of receipt
Electronic submission After reception of the complete grant/fellowship
The electronic research grant application must be application by the ELA Research Department, the
submitted by midnight CET on May, 28th, 2018 PI, co-investigators (if applicable), fellow, supervisor
(Paris time). and legal grant officer(s) will receive an
acknowledgment of receipt to the e-mail addresses
Signed paper pages entered in the grant application.
Original application pages requiring a signature
(and only these) must contain the required Maximum submissions
SIGNATURES AND SEALS and must arrive by A maximum of 2 grant applications can be
June 1st, 2018 to: ELA – Research Department - 14, submitted by the same investigator to ELA
rue La Fayette - 75009 Paris, France. International.
Only one fellowship (either Ph.D. or postdoctoral)
Along with the signed paper pages, include a cover application is allowed per laboratory.
letter documenting the application title, type of Resubmission
research project (individual, collaborative, The same application cannot be resubmitted more
fellowship) and disciplines involved if than 3 times.
multidisciplinary project. For fellowship, the letter
must describe the fellow’s career goals. In this
letter, list referees (with their contact information) IV. SUPPORT
who should not review your application because of For assistance, contact the Scientific Coordinator of
conflict of interest. Mandatory: give three names of ELA at ELA – Research Department - 14, rue La
referee with their contact information (excluding Fayette - 75009 Paris, France.
your project’s collaborators) that you judge qualified
E-mail: elise.vivar@ela-asso.com
to evaluate your project (Yet other experts might be
considered to evaluate your proposal).
III. GENERAL CONSIDERATIONS
No signed paper pages will be returned.
The application must be complete and accurate at
the time of submission. An application is considered
complete only when accurate electronic and signed
paper pages have both been received by their
respective deadlines.
Incomplete applications will be administratively
withdrawn and not returned to the applicant.
Late applications will not be accepted.
Modifications
The electronic and signed paper pages must match
entirely. No modifications are allowed. If changes
are being made, the application will be withdrawn. If
minor administrative changes are needed after
submission (such as budget miscalculations,
incorrect address…), the principal investigator
needs to contact the ELA Scientific Coordinator.
Supplementary material
No supplementary material or updates will be
accepted after the deadline. The only exceptions
are missing documentation requested by ELA
Research Department.
Scientific Overlap
Grant/Fellowship applications showing identical or
significantly similar content will be rejected. Only
applications with strictly different aims may be
funded.
2018 ELA Grant Instructions & Policies Page 6/9B. ELA GRANT POLICIES
with the grant agreements. Grant agreements will
I. GENERAL GUIDELINES ONLY be processed when the Research Support
form will be received by ELA International.
WARNING
The application must be complete and accurate at II. OBLIGATIONS of the APPLICANT &
the time of submission. An application is considered INSTITUTION
complete only when accurate electronic and signed II.1. The grant/fellowship is allocated for the
paper pages have both been received by their execution of the Research Project submitted by the
respective deadlines. Applicants to ELA International (referred to as the
Incomplete applications will be administratively “Research Project”).
withdrawn and not returned to the applicant.
II.2. In return for the grant allocated, the Applicants
I.1. In signing the application, the principal are committed to:
investigator, co-investigators, fellowship applicant
A. Inform ELA International of a possible
and his/her supervisor and legal grant officer(s)
interruption of the Research Project,
(hereinafter referred to as the “Applicants”) agree to
comply with the ELA International policies. B. Ask ELA International for approval before any
changes need to be made to the Research Project,
I.2. On no account does a grant by ELA
International constitute an established right. C. Submit a detailed progress report to ELA
International within a year, and, in all cases, prior to
I.3. Assurances & Ethical Issues
any renewal of the Research Project and at the end
If ethical approval is required for the Research
of the Research Project,
Project, the Applicants and their respective
institutions are responsible for ensuring that D. Submit within a year a lay summary describing
appropriate authorization and assurance for the the progress of the Research Project to ELA
protection of human subjects and animals is being International in view of transparency for the public
contracted. Animal experimentation and use of whose generosity has enabled the funding of the
material of human origin related to the proposed Research Project, under the restriction of
project must be carried out in agreement with the confidentiality when some information in the lay
Applicants’ institutions rules and regulations. summary is likely to be protected by intellectual
property.
I.4. Privileged Communication
Material and information provided by the Applicants E. Submit a financial report to ELA International
in the grant/fellowship application are considered within a year and, in all cases, prior to any renewal
privileged communication with the exception of the of the Research Project or to the submission of new
lay summary that will become public information if grant applications. The financial report will be
the proposal is funded. signed by the manager of the Institution’s
Accounting Services, and will detail the utilization of
I.5. Equipment purchase
the funds awarded under the Grant Agreement.
Equipment bought with ELA funds are considered a
donation made to the Applicant and his/her F. Acknowledge the support of ELA International in
institution. all documents to be published and presented about
the Research Project using the grant number
I.6. Equipment repair & maintenance
provided by ELA International.
ELA International does not cover expenses related
to equipment repair and/or maintenance. G. Participate to the ELA Families-Scientists
Meeting and the ELA Scientific Congress upon
I.7. Missing reports
ELA’s request.
Teams awarded grants from ELA International in
the past are reminded that receipt of missing II.3. All necessary approvals for the conduct of the
reports/documents related to past awards, as Research Project must be obtained by the
indicated in the signed grant agreements, is Applicants from their institutions prior to the start of
awaited. the Research Project.
I.8. Research support II.4. The Applicants commits to inform ELA
If the application is approved by ELA International, International of any other grant applications
a new Research Support form (one per application) submitted to other funding agencies overlapping
will have to be submitted to ELA International along partially or entirely with the Research Project when
2018 ELA Grant Instructions & Policies Page 7/9these applications are submitted. In the event the investigators and scientists with permanent or
Applicants are awarded a grant overlapping with the tenure-track positions.
Research Project, they must notify ELA
VII.2. Grant Agreements & Money transfer
International within one month of receiving the
The grant agreements will be issued by ELA
award notification in order to review the financial
International.
participation of ELA International to the Research
The money transfer related to the Applicants’ grant
Project and establish the co-financing
will be set up upon reception of two original signed
arrangements.
grant agreements issued by ELA International, after
II.5. All resumes of personnel to be hired to work on validation of these documents by ELA International.
the Research Project must be sent to ELA As the funds are allocated to the Institution, the
International shortly after their recruitment. money will be transferred directly to the Institution’s
bank account. Transfer of funds to intermediaries
III. MONITORING (like associations or others) will not be accepted.
ELA International is entitled, at any time, to ask the
VII.3. Budget considerations
Applicants to provide additional information and/or
The Applicants and the Institution are REQUIRED
results about the Research Project underway.
to use the funds of the grant/fellowship according to
These additional information and/or results will be
the budget lines indicated in the signed grant
kept confidentially by ELA International.
agreement.
ELA International authorizes transfers between
IV. PUBLICATIONS
categories (personnel costs, supplies, equipment
ELA International must be informed of any type of
and travel) without being previously informed only
publication or communication regarding the
when the transfer represents less than 20 % of the
execution, development and results of the present
category to be reduced. When the transfer exceeds
Research Project, or its follow-up.
20%, a written authorization from ELA International
These publications and communications must, in
in the form of an amendment modifying the original
every case, mention the contribution provided by
grant agreement is required beforehand. This
ELA International to the execution or follow-up of
written authorization must be granted before the
the Research Project.
end of the period covered by the active agreement.
V. SANCTIONS VII.4. Financial report
ELA International reserves the right to apply The Institution is required to submit to ELA
adequate sanctions as stipulated in the grant International by the end of budget period or upon
agreement (document available upon request). ELA’s request a financial report signed by the
manager of the institution’s accounting services and
VI. AWARD ACTIVATION detailing the utilization of the funds awarded
The date of award activation will be decided by the respecting the budget lines indicated in the signed
Applicants and the Institution but cannot be set prior grant agreement. For all expenses exceeding 4 000
to January 1st, 2019. €, the corresponding invoices must be sent to ELA
International at the time of submission of the
VII. FINANCIAL GUIDELINES financial report.
VII.5. Credit balance
WARNING
Any funds not used according to the grant
The legal grant officer(s) must certify the budget
agreement or any unspent funds will have to be
figures by signing the budget form and stamping it
reimbursed to ELA International.
with the seal of the institution.
VII.6. Credit rollover
VII.1. Salaries & Overheads No credit rollovers will be allowed if at the end of
Salaries for Ph.D. students and postdoctoral fellows the Research Project the funding has not been fully
or other personnel must match the salary grid of the spent.
applicant’s country. The corresponding grid needs
to be submitted by the applicant. VIII. LEGAL DISPUTES
Fringe benefits are supported by ELA International Any and all disputes between ELA International and
and are required for all personnel including Ph.D. the Institution arising concerning the validity,
students and postdoctoral fellows. interpretation or execution of the Grant Agreement,
ELA International neither covers overhead/indirect that could not be settled amicably, shall be
costs nor salaries for principal investigators, co- submitted to the relevant courts.
2018 ELA Grant Instructions & Policies Page 8/9ELA International Research Department 14, rue La Fayette 75009 Paris France Tel: +33 (0)1 40 79.49.35 Fax: +33 (0)3 83 30 00 68 http://elainternational.eu/site/en/ 2018 ELA Grant Instructions & Policies Page 9/9
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