Carlotta Ciaramelli - Bicocca
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Carlotta Ciaramelli
Academic education
Jul 2009 Bachelor degree in Chemistry at University of Naples Federico II.
Thesis in organic chemistry: “Costituenti glicidici e lipidici da Roseivirga ehrenbergii”.
Mentor: Prof. R. Lanzetta, Dr. C. De Castro. Final grade: 110/110 with honours.
Jul 2011 Master degree in Chemical Sciences at University of Naples Federico II.
Thesis in organic chemistry: “Structure determination of membrane saccharidic constituents
from Rhizobium vitis”. Mentor: Prof. R. Lanzetta, Dr. C. De Castro.
Final grade: 110/110 with honours.
Mar 2015 PhD in Chemical Sciences at University of Milano - Bicocca.
“Synthesis and characterization of new small-molecule ligands of LPS binding proteins.”
Mentor: Prof. Francesco Peri.
Research experience
Jan 2015 - Dec 2016 Post-Doc fellow at bio-NMR laboratory, Dept. of Biotechnology and Biosciences,
University of Milano - Bicocca.
Post-Doc fellowship by CARIPLO foundation: “BALf metabolomics in chronic lung
rejection: an innovative approach to identify predictive markers and sub-phenotypes.”
Mentor: Dr. Cristina Airoldi.
Jan - Jun 2017 Post-Doc fellow at bio-NMR laboratory, Dept. of Biotechnology and Biosciences,
University of Milano - Bicocca.
Post-Doc fellowship: “Glycoproteomics: a new combined approach of synthesis and
structural analysis by NMR.”
Mentor: Dr. Cristina Airoldi.
Jul 2017 – Jun 2018 Post-Doc fellow at bio-NMR laboratory, Dept. of Biotechnology and Biosciences,
University of Milano - Bicocca.
Post-Doc fellowship: “Applicazioni della spettroscopia NMR allo studio dei sistemi
biologici.”
Mentor: Dr. Cristina Airoldi.
Jul – Oct 2018 Post-Doc fellow at bio-NMR laboratory, Dept. of Biotechnology and Biosciences,
University of Milano - Bicocca.
“Annalaura Segre” Post-Doc fellowship by GIDRM: “NMR-based screening of cocoa
extracts for the identification of ligands of β-amyloid and Ataxin-3 oligomers.”
Mentor: Dr. Cristina Airoldi.
Nov 2018 Post-Doc fellow at bio-NMR laboratory, Dept. of Biotechnology and Biosciences,
University of Milano - Bicocca.
Post-Doc fellowship: “NMR-driven dissection of the neuroprotective effects of natural
extracts from edible sources and their main constituents: implications for the
prevention of neurodegenerative diseases.” Mentor: Dr. Cristina Airoldi.
1Research activity
During the Bachelor and Master thesis periods in the labs of Prof. Lanzetta and Dr. De Castro, the focus of my
research project was the chemical characterization of glycolipidic Gram-negative bacteria endotoxins
(lipopolysaccharides or LPS), directly purified from different bacteria. To this purpose, I developed good
knowledge in both purification methods and spectroscopic and spectrometric techniques (NMR spectroscopy
and mass spectrometry) for the structural analysis of biomacromolecules.
Then, I moved to the University of Milano - Bicocca for a PhD in Chemical Sciences under the supervision of
Prof. Francesco Peri. The topic of my PhD thesis was the design, synthesis, structural and biological
characterization of bio-active small molecules. These compounds were tested for their activity on LPS binding
proteins. The work was supported by NMR interaction studies between synthetic ligands and purified receptors
that I deepened during my research period abroad in Madrid, in Prof. J. Jimenez-Barbero’s group.
Now I am a Post-Doc fellow, under the supervision of Dr. Cristina Airoldi. My current scientific interest
concerns the application of NMR spectroscopy to both metabolomics and molecular recognition studies. In
particular, my research projects are focused on the identification of metabolic markers of pathologies from
biofluids and on the study of the metabolic profile of food matrices, but also on the NMR characterization of
biologically relevant molecular interactions and recognition processes.
Research experience abroad
Oct – Dec 2012 C.O.S.T. BM1003 STSM (Short Term Scientific Mission): “NMR characterization of the
interaction between natural and synthetic TLR4-active compounds and MD-2.” Prof. Jesús
Jiménez-Barbero, Centro de Investigaciones Biológicas (CIB) - CSIC, Madrid, Spain.
Publications
1) R. Cighetti, C. Ciaramelli, S. E. Sestito, I. Zanoni, Ł. Kubik, A. Ardá-Freire, V. Calabrese, F. Granucci,
R. Jerala, S. Martín-Santamaría, J. Jiménez-Barbero, F. Peri. Modulation of CD14 and TLR4.MD-2
activities by a synthetic lipid A mimetic, ChemBioChem. 2014, 15, 250-8.
2) S. E. Sestito, P. Sperandeo, C. Santambrogio, C. Ciaramelli, V. Calabrese, G.E. Rovati, L. Zambelloni,
R. Grandori, A, Polissi, F. Peri. Functional characterization of E. coli LptC: interaction with LPS and a
synthetic ligand. ChemBioChem. 2014, 15, 734–742.
3) E. Ferri, A. Galimberti, M. Casiraghi, C. Airoldi, C. Ciaramelli, A. Palmioli, V. Mezzasalma, I. Bruni,
M. Labra. Towards a universal approach based on omics technologies for the quality control of food.
BioMed Research International. 2015, Article ID 365794, 1-14.
4) C. Ciaramelli, V. Calabrese, S. E. Sestito, L. Pérez-Regidor, J. Klett, A. Oblak, R. Jerala, M. Piazza, S.
Martín-Santamaría, F. Peri. Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design,
Synthesis, and Biological Properties. Chemical Biology & Drug Design. 2016, 88, 217–229.
5) C. Airoldi, C. Ciaramelli, M. Fumagalli, R. Bussei, V. Mazzoni, S. Viglio, P. Iadarola, J. Stolk. 1H-NMR
to explore the metabolome of exhaled breath condensate in α1-antitrypsin deficient patients: a pilot study.
Journal of Proteome Research. 2016, 15(12), 4569–4578.
6) C. Ciaramelli, M. Fumagalli, S. Viglio, A. M. Bardoni, D. Piloni, F. Meloni, P. Iadarola, C. Airoldi. 1H-
NMR to evaluate the metabolome of bronchoalveolar lavage fluid (BALf) in bronchiolitis obliterans
2syndrome (BOS): towards the development of a new approach for biomarker identification. Journal of
Proteome Research. 2017, 16, 1669-1682.
7) L. Amigoni, M. Stuknytė, C. Ciaramelli, C. Magoni, I. Bruni, I. De Noni, C. Airoldi, M. E. Regonesi, A.
Palmioli. Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis
elegans. Journal of functional foods. 2017, 33, 297-306.
8) Y. Zeinolabediny, F. Caccuri, L. Colombo, F. Morelli, M. Romeo, A. Rossi, S. Schiarea, C. Ciaramelli,
C. Airoldi, R. Weston, L. Donghui, J. Krupinski, R. Corpas, E. García-Lara, S. Sarroca, C. Sanfeliu, M.
Slevin, A. Caruso, M. Salmona, L. Diomede. HIV-1 matrix protein p17 misfolding forms toxic
amyloidogenic assemblies that induce neurocognitive disorders. Scientific Reports. 2017, 7, 10313,
DOI:10.1038/s41598-017-10875-0.
9) A. Palmioli*, C. Ciaramelli*, R. Tisi, M. Spinelli, G. De Sanctis, Elena Sacco, C. Airoldi. Natural
Compounds in Cancer Prevention: Effects of Coffee Extracts and Their Main Polyphenolic Component,
5-O-Caffeoylquinic Acid, on Oncogenic Ras Proteins. Chem. Asian J. 2017, 12, 2457 – 2466.
+
These authors contributed equally to this work.
10) C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C. P. Zoia, M. Salmona, C. Airoldi.
NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts. Food
Chemistry, 2018, 252, 171–180.
11) C. Airoldi, B. La Ferla, G. D’Orazio, C. Ciaramelli, A. Palmioli. Flavonoids in the treatment of
Alzheimer’s and other neurodegenerative diseases. Current Medicinal Chemistry. 2018, 25 (27), 3228-
3246.
12) F. A. Facchini, L. Zaffaroni, A. Minotti, S. Rapisarda, V. Calabrese, M. Forcella, P. Fusi, C. Airoldi, C.
Ciaramelli, J.-M. Billod, A. Schromm, H. Braun, C. Palmer, R. Beyaert, R. Jerala, G. Pirianov, S. Martin
Santamaria, F. Peri. Structure-activity relationship (SAR) in monosaccharide based Toll-like receptor 4
(TLR4) antagonists. J. Med. Chem. 2018, 61 (7), 2895–2909.
13) C. Ciaramelli, A. Palmioli, C. Airoldi. Coffee variety, origin and extraction procedure: Implications for
coffee beneficial effects on human health. Food Chemistry, 2019, 278, 47-55.
14) S. Viglio, C. Airoldi, C. Ciaramelli, P. Iadarola. Nuclear Magnetic Resonance as an Attractive Resource
for Monitoring Surveillance Candidates of Acute and Chronic Lung Disorders Nuclear Magnetic
Resonance as an Attractive Resource for Monitoring Surveillance Candidates of Acute and Chronic Lung
Disorders. Applications of NMR Spectroscopy, 2018, 7, 21-62.
Abstract Publications in journals
C. Airoldi, C. Ciaramelli, M. Fumagalli, S. Magni, S. Viglio, D. Piloni, A. Bardoni, P. Iadarola, F. Meloni.
Optimizing a protocol for the NMR-based metabolic profiling of BALf in bronchiolitis obliterans syndrome.
European Respiratory Journal. 2016, 48, PA4634. DOI: 10.1183/13993003.congress-2016.PA4634.
M. Fumagalli, J. Stolk, C. Ciaramelli, R. Bussei, V. Mazzoni, S. Viglio, P. Iadarola, C. Airoldi. Exploiting the
ability of 1H-NMR to differentiate patients with severe alpha-1-antitrypsin deficiency from controls based on
metabolome profiling of exhaled breath condensate. European Respiratory Journal. 2016 48, OA1971. DOI:
10.1183/13993003.congress-2016.OA1971.
3Awards
Jun 2014 XIV Convegno Scuola sulla Chimica dei Carboidrati, Certosa di Pontignano, Siena, Italy.
Awarded as the best contribution to the Congress by Giotto Biotech: C. Ciaramelli, V.
Calabrese, S. E. Sestito, R. Cighetti, F. Peri, New small molecules active on LPS binding
proteins.
Sep 2018 XXXVIII Convegno Nazionale della Divisione di Chimica Organica della Società Chimica
Italiana, Milano, Italy.
Winner of the ChemPubSoc Poster Award: C. Ciaramelli, A. Palmioli, A. De Luigi, L.
Colombo, G. Sala, C. Riva, C. P. Zoia, M. Salmona, C. Airoldi. NMR-based screening of
green and roasted coffee extracts to identify anti-amyloidogenic compounds.
Fellowships
2012 - 2014 University of Milano – Bicocca.
Fellowship for PhD in Chemical Sciences.
Oct - Dec 2012 Centro de Investigaciones Biológicas (CIB) - CSIC, Madrid, Spain.
Fellowship for a STSM (Short Term Scientific Mission) from C.O.S.T. BM1003 action.
Jun 2014 XXXIX "Attilio Corbella" Summer School on Organic Synthesis, Gargnano (BS), Italy.
Fellowship for school attendance.
Jun 2014 XIV Convegno Scuola sulla Chimica dei Carboidrati, Certosa di Pontignano, Siena, Italy.
Fellowship for congress-school attendance.
Sep 2015 XLIV National Congress on Magnetic Resonance, Roma, Italy.
Full fellowship for congress attendance.
May 2016 V Workshop Applicazioni della Risonanza Magnetica nella Scienza degli Alimenti, Roma,
Italy.
Fellowship for congress attendance.
Sept 2016 XLV National Congress on Magnetic Resonance, Modena, Italy.
Full fellowship for congress attendance.
Sept 2016 Scuola NMR Avanzata, Torino, Italy.
Fellowship for congress attendance.
May 2018 “Annalaura Segre” fellowship by GIDRM
Post-Doc fellowship
Sept 2016 XLVII National Congress on Magnetic Resonance, Torino, Italy.
Full fellowship for congress attendance.
4Schools and congresses
May 2011 Basic NMR School. “Corso teorico pratico di Risonanza Magnetica Nucleare di base per lo
studio di molecole in soluzione”, CIMCF, University of Naples Federico II.
May 2011 Advanced NMR School. “Corso teorico pratico di Risonanza Magnetica Nucleare in alto
campo”, CIMCF, University of Naples Federico II.
Jul 2011 XVI European Carbohydrate Symposium, Sorrento, Italy.
Jun 2012 C.O.S.T. BM1003 Workshop 2012: “Molecular Determinants of bacterial diseases”, Napoli,
Italy.
Jun 2012 XIII Convegno Scuola sulla Chimica dei Carboidrati, Certosa di Pontignano, Siena, Italy.
Poster contribution: C. Ciaramelli, V. Calabrese, F. Peri, New Molecules Active On TLR4-
LPS Signalling: Synthetic Lipid A analogues and chemically modified LPS.
Jul 2012 26th International Carbohydrate Symposium, Madrid, Spain.
Poster contribution: C. Ciaramelli, V. Calabrese, F. Peri, New Molecules Active On TLR4-
LPS Signalling: Synthetic Lipid A analogues and chemically modified LPS.
Oral contribution: Peri, F.; Calabrese, V., Granucci, F.; Zanoni, I.; Weiss, J.; Gioannini, T.;
Ciaramelli, C.; Cighetti, R.; Sestito, S.; Piazza, M.; Carbohydrate-derived synthetic molecules
active on endotoxin/TLR4 signaling.
Jun 2013 XXXVIII "Attilio Corbella" Summer School on Organic Synthesis, Gargnano (BS), Italy.
Poster contribution: C. Ciaramelli, V. Calabrese, S. E. Sestito, F. Peri, Towards new TLR4
active small molecules.
Aug 2013 15th ICI satellite meeting, SM7 “Endotoxin, TLR4 signaling and beyond”, Cinisello Balsamo,
Milano, Italy.
Poster contribution: C. Ciaramelli, V. Calabrese, S. E. Sestito, F. Peri, Fluorescent probes:
TLR4 active small molecules and chemically modified LPS.
Oral contribution: F. Peri, J.Weiss, T. Gioannini, M. Piazza, V. Calabrese, F. Granucci, I.
Zanoni, D. Prosperi, A. Polissi, C. Ciaramelli, S. E. Sestito, R. Cighetti, S. Gugliotta, Toll-like
receptor 4 (TLR4) modulation by synthetic molecules.
Poster contribution: S. E. Sestito, C. Ciaramelli, V. Calabrese, L. Zambelloni, P. Sperandeo,
G.E. Rovati, A, Polissi and F. Peri, LptC-PLS binding: a new target for antibacterial
compounds.
Nov 2013 24th Joint Glycobiology Meeting, Wittenberg, Germany.
Poster contribution: S. E. Sestito, C. Ciaramelli, V. Calabrese, P. Sperandeo, L. Zambelloni,
G.E. Rovati, A, Polissi and F. Peri, LptC-PLS binding: a new target for antibacterial
compounds.
Dec 2013 BtBs Day, University of Milano - Bicocca, Milano, Italy.
Poster contribution: C. Ciaramelli, V. Calabrese, S. E. Sestito, F. Peri, Fluorescent probes:
TLR4 active small molecules and chemically modified LPS.
Oral contribution: V. Calabrese, R. Cighetti, C. Ciaramelli, S. E. Sestito, S. Gugliotta, L.
Zambelloni, D. Zaccarin, M. Claseri, F. Peri. Small molecules: from design to biological
characterization.
5Jun 2014 XXXIX "Attilio Corbella" Summer School on Organic Synthesis, Gargnano (BS), Italy.
Oral and poster contribution: C. Ciaramelli, V. Calabrese, S. E. Sestito, R. Cighetti F. Peri,
Synthesis and characterization of new small molecules active on LPS binding proteins.
Jun 2014 XIV Convegno Scuola sulla Chimica dei Carboidrati, Certosa di Pontignano, Siena, Italy.
Oral and poster contribution: C. Ciaramelli, V. Calabrese, S. E. Sestito, R. Cighetti, F. Peri,
New small molecules active on LPS binding proteins.
Oral contribution: F. Peri, C. Ciaramelli, V. Calabrese, S. E. Sestito, R. Cighetti. New
perspectives in therapeutic targeting of Toll-Like Receptor 4 (TLR4) with synthetic
glycolipids.
Sep 2014 XXV Congresso della Società Chimica Italiana, Arcavacata di Rende (CS), Italy.
Oral contribution: V. Calabrese, F. Peri, C. Ciaramelli, S. E. Sestito, R. Cighetti, From Lipid
A-like structures to simplified small molecules active on TLR4.
Oral contribution: F. Peri, V. Calabrese, C. Ciaramelli, S. E. Sestito, R. Cighetti, Synthetic
glycolipids active on TLR4 receptor: a new generation of therapeutics.
Jun 2015 Bioanalitica 2015: Nuovi approcci bioanalitici per la determinazione di sostanze ad attività
biologica, farmaceutica e nutraceutica, Firenze, Italy.
Poster contribution: A. Palmioli, C. Ciaramelli, M. Stuknytė, L. Colombo, A. De Luigi, M.
Spinelli, E. Sacco, I. Bruni, M. E. Regonesi, I. De Noni, M. Labra, C. Airoldi, Green coffee
bean extracts as potential neuroprotective and chemoprotective dietary supplements: a
molecular point of view.
Poster contribution: V. Mazzoni, A. Palmioli, C. Ciaramelli, L. Colombo, A. De Luigi, E.
Dosoli, C. Airoldi, Natural compounds against Alzheimer’s disease: effects of hop extracts on
Aβ peptide-induced toxicity on neuronal cell lines.
Sep 2015 IV International Conference on Analytical Proteomics, Lisbon, Portugal.
Poster contribution: C. Airoldi, C. Ciaramelli, M. Fumagalli, S. Viglio, A. Bardoni, F. Meloni,
P. Iadarola, A pilot study to evaluate the metabolome of Broncho Alveolar Lavage fluid
(BALf) in Bronchiolitis Obliterans Syndrome.
Sep 2015 XLIV National Congress on Magnetic Resonance, Roma, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, J. Nava, A. De Luigi, L. Colombo, M. Spinelli,
E. Sacco, M. E. Regonesi, C. Airoldi, Green coffee bean extracts as potential neuroprotective
and chemoprotective dietary supplements.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. Bardoni, F. Meloni, P. Iadarola,
C. Airoldi, NMR-based metabolic profiling of Broncho Alveolar Lavage fluid (BALf) in
Bronchiolitis Obliterans Syndrome.
Dec 2015 BtBs Day, University of Milano - Bicocca, Milano, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, J. Nava, A. De Luigi, L. Colombo, M. Spinelli,
E. Sacco, M. E. Regonesi, C. Airoldi, Green coffee bean extracts as potential neuroprotective
and chemoprotective dietary supplements.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. Bardoni, F. Meloni, P. Iadarola,
C. Airoldi, NMR-based metabolic profiling of Broncho Alveolar Lavage fluid (BALf) in
Bronchiolitis Obliterans Syndrome.
Dec 2015 Workshop on metabolomics by HR-MAS NMR: from data acquisition to peak identification
and multivariate analysis, Milano, Italy.
6May 2016 V Workshop Applicazioni della Risonanza Magnetica nella Scienza degli Alimenti, Roma,
Italy.
Oral contribution: C. Ciaramelli, A. Palmioli, R. Bussei, J. Nava, A. De Luigi, L. Colombo,
C. Airoldi, Screening via NMR di estratti di caffè con potenziale attività neuroprotettiva.
Oral contribution: C. Airoldi, C. Ciaramelli, A. Palmioli, V. Mazzoni, R. Bussei,
Caratterizzazione NMR di estratti naturali da piante edibili: dal profiling metabolico
all’identificazione di composti anti-amiloidogenici.
Jun 2016 NMR Day: Industrial applications of proteins: what role of NMR?, Firenze, Italy.
Jun 2016 Second International Meeting of the Milan Center for Neuroscience (NeuroMi), Milano, Italy.
Poster contribution: C. Airoldi, C. Ciaramelli, V. Mazzoni, A. Palmioli, R. Bussei L. Colombo,
A. De Luigi, F. Nicotra, NMR-based identification of anti-Alzheimer’s compounds in edible
plants and foods.
Sept 2016 XLV National Congress on Magnetic Resonance, Modena, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, J. Nava, R. Bussei, A. De Luigi, L. Colombo,
G. Sala, C. P. Zoia, C. Airoldi. Beneficial properties of coffee extracts: an NMR study to
account for potential neuroprotective activity.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. Bardoni, F. Meloni, P. Iadarola,
C. Airoldi, NMR-based metabolomics of Broncho Alveolar Lavage fluid (BALf) to
investigate chronic lung rejection.
Sept 2016 Scuola NMR Avanzata - GIDRM, Torino, Italy.
Dec 2016 BtBs Day, University of Milano - Bicocca, Milano, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, J. Nava, R. Bussei, A. De Luigi, L. Colombo,
G. Sala, C. P. Zoia, C. Airoldi. Beneficial properties of coffee extracts: an NMR study to
account for potential neuroprotective activity.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. Bardoni, F. Meloni, P. Iadarola,
C. Airoldi. NMR-based metabolomics of Broncho Alveolar Lavage fluid (BALf) to
investigate chronic lung rejection.
Jul 2017 International Symposium on Protein Misfolding Diseases, Catania, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, R. Bussei, A. De Luigi, L. Colombo, G. Sala,
C. P. Zoia, C. Airoldi. Potential Neuroprotective Activity of Coffee Extracts and their
Principal Components.
Sep 2017 SMASH – Small Molecule NMR Conference, Baveno (VCO), Italy.
Oral contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. M. Bardoni, D. Piloni, F. Meloni,
P. Iadarola, C. Airoldi. 1H-NMR to evaluate the metabolome of Bronchoalveolar Lavage Fluid
(BALf) in Bronchiolitis Obliterans Syndrome (BOS).
Poster contribution: R. Bussei, S. Castegnaro, C. Ciaramelli, S. Mari, C. Airoldi. Towards the
Optimization of the Identification and Quantification of Serum Metabolites.
Sep 2017 XLVI National Congress on Magnetic Resonance, Salerno, Italy.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. M. Bardoni, D. Piloni, F.
Meloni, P. Iadarola, C. Airoldi. NMR-based metabolomics study of Bronchoalveolar Lavage
Fluid (BALf) from Bronchiolitis Obliterans Syndrome (BOS) patients.
7Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. P. Zoia,
C. Airoldi. Potential neuroprotective activity of coffee extracts and their principal components:
the NMR point of view.
Poster contribution: R. Bussei, S. Castegnaro, C. Ciaramelli, S. Mari, C. Airoldi. NMR-based
metabolomics of serum: an automatic approach for metabolite identification and
quantification.
Dec 2017 BtBs Day, University of Milano - Bicocca, Milano, Italy.
Poster contribution: C. Ciaramelli, M. Fumagalli, S. Viglio, A. M. Bardoni, D. Piloni, F.
Meloni, P. Iadarola, C. Airoldi. NMR-based metabolomics study of Bronchoalveolar Lavage
Fluid (BALf) from Bronchiolitis Obliterans Syndrome (BOS) patients.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. P. Zoia,
C. Airoldi. Potential neuroprotective activity of coffee extracts and their principal components:
the NMR point of view.
Poster contribution: R. Bussei, S. Castegnaro, C. Ciaramelli, S. Mari, C. Airoldi. NMR-based
metabolomics of serum: an automatic approach for metabolite identification and
quantification.
Feb 2018 Workshop “I chimici per le biotecnologie”, Bologna, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C.
P. Zoia, M. Salmona, C. Airoldi. NMR-based identification of anti-amyloidogenic compounds
in green and roasted coffee extracts.
Sep 2018 XXXVIII Convegno Nazionale della Divisione di Chimica Organica della Società Chimica
Italiana, Milano, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C.
P. Zoia, M. Salmona, C. Airoldi. NMR-based screening of green and roasted coffee extracts
to identify anti-amyloidogenic compounds.
Sep 2018 XLVII National Congress on Magnetic Resonance, Torino, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, M. Spinelli, G. De Sanctis, R. Tisi, E. Sacco,
C. Airoldi. Effect of coffee extracts and their main polyphenolic component 5-CQA on
oncogenic RAS proteins.
Poster contribution: C. Ciaramelli, A. Palmioli, C. Airoldi. 1H-NMR to evaluate the influence
of variety, origin and extraction procedure on coffee beneficial effects for human health.
Nov 2018 Fourth International Meeting of the Milan Center for Neuroscience (NeuroMi), Milano, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C.
P. Zoia, C. Ferrarese, M. Salmona, C. Airoldi, Potential nutraceuticals against
neurodegenerative diseases: an NMR-based study to identify anti-amyloidogenic compounds
in coffee extracts.
Nov 2018 The BtBs project of excellence: kick-off meeting (BtBs Day), University of Milano - Bicocca,
Milano, Italy.
Oral contribution: C. Ciaramelli, NMR-driven dissection of the neuroprotective effects of
natural extracts from edible sources and their main constituents: implications for the
prevention of neurodegenerative diseases.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C.
P. Zoia, M. Salmona, C. Airoldi. NMR-based identification of anti-Alzheimer’s compounds
in coffee extracts.
8Feb 2019 Workshop “I chimici per le biotecnologie”, Milano, Italy.
Poster contribution: C. Ciaramelli, A. Palmioli, A. De Luigi, L. Colombo, G. Sala, C. Riva, C.
P. Zoia, M. Salmona, C. Airoldi. NMR-driven identification of anti-amyloidogenic
compounds in coffee extracts.
Didactic activities
2012-2013 Co-professor of Organic Chemistry Lab (Bachelor Degree in Biotechnologies) at the
University of Milano – Bicocca
2013-2014 Co-professor of Organic Chemistry Lab (Bachelor Degree in Biotechnologies) at the
University of Milano – Bicocca
2015-2016 Co-professor of Organic Chemistry Lab (Bachelor Degree in Biotechnologies) at the
University of Milano – Bicocca
2016-2017 Co-professor of Organic Chemistry Lab (Bachelor Degree in Biotechnologies) at the
University of Milano – Bicocca
2016-2017 Co-professor of Organic Chemistry Lab (Bachelor Degree in Biological Sciences) at the
University of Milano – Bicocca
2017-2018 Professor of Organic Chemistry Lab (Bachelor Degrees in Biotechnologies) at the University
of Milano – Bicocca
2018-2019 Professor of Organic Chemistry Lab (Bachelor Degree in Biological Sciences) at the
University of Milano – Bicocca
2018-2019 Professor of Organic Chemistry Lab (Bachelor Degrees in Biotechnologies) at the University
of Milano – Bicocca
2017 Tutor for “Progetto Lauree Scientifiche” for High School students at the University of Milano
– Bicocca
2018 Tutor for “Progetto Lauree Scientifiche” for High School students at the University of Milano
– Bicocca
2013-2014 Co-relator of the thesis: “Sintesi di sostanze attive sul recettore TLR4”, Andrea Sala, bachelor
degree in Chemistry, University of Milano – Bicocca.
2015-2016 Co-relator of the thesis: “Caratterizzazione preliminare dell’effetto dell’acido clorogenico, la
principale componente polifenolica degli estratti di caffè, sull’attività delle proteine RAS”,
Jessica Nava, master degree in Industrial Biotechnologies, University of Milano – Bicocca.
2017-2018 Co-relator of the thesis: “Profiling metabolico via NMR di biofluidi derivanti da pazienti
affetti da patologie polmonari.”, Francesca Chiappano, master degree in Industrial
Biotechnologies, University of Milano – Bicocca.
9Languages
English: Advanced (C1). IELTS level 7.5, June 2011. Spanish: Intermediate.
Professional qualifications
- Qualifying examination for chemist profession (2012).
- NMR operator license both for low and high field instruments, CIMCF of the University of Naples (2011).
- ECDL (European Computer Driving License).
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