Apollo's - Singapore Medical ...

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FEATURE

             A &                   pollo’s
                                    rrows
                                                                                           Sun Tzu’s
                                                                                           Stratagem

                                                   Text by Dr Gan Wee Hoe | Photos by SingHealth and SGH

           The culprit causing COVID-19 has been             This is an infection where the fallout       Another epochal event was the 1918
           described as a “very smart virus [that] will   – in terms of mortality, socio-economic     influenza pandemic. It started at the tail
           find ways to remain in the human pop-          consequences and the profound impact        end of World War I (WWI), when the four
           ulation”.1 An infected patient recounted       on the way of living as we know it – is     years of war prior had already resulted
           how battling the disease was akin to           of monumental proportions. By many          in insufferable hardship and depletion
           “running a marathon on the bed”.2              accounts, we may only be at the end of      of resources.
              These are just two of the many              the beginning.
                                                                                                         The H1N1 virus infected one-third
           crippling accounts of COVID-19 that                                                        of the world’s population and was
           have emerged since the tentacles of this       Pandemics in human history                  associated with at least 50 million
           pandemic first surfaced at the turn of         The bubonic plague in the 14th century      deaths. The epidemiological observation
           the decade.                                    wiped out almost a third of Europe’s        of the high mortality in the 20- to
              On 31 December 2019, the Wuhan              population. Caused by Yersinia pestis       40-year-old age group (apart from the
           Municipal Health Commission reported           and spread by infected fleas carried by     young and the elderly) was surprising
           to the World Health Organization (WHO)         rodents to humans, the disease was so       to many. During WWI, the US had joined
           China Country Office on a cluster of pneu-     contagious that it has been described       to aid the Allies’ eventual victory against
           monia cases occurring in the capital city      by the Italian poet Giovanni Boccaccio      Germany. Of the US fatalities on the war
           of Hubei province. Subsequent reports          that “the mere touching of the clothes      front, half were due to influenza and not
           suggest that the first case could be traced    appeared to itself to communicate the       attributed to direct enemy action.6
           back to as early as 17 November 2019.3         malady to the toucher”.4                        Ironically, WWI also shaped the social
               Much has been postulated, re-                 Ships were sailing into ports with       attitudes among the citizenry in many
           searched and written about COVID-19.           crew either severely ill or dead. To        countries, who were by then used to
           At the time of writing, global case count      stem the spread of infection, officials     restrictions in their daily lives. This,
           has crossed the five-million mark with         kept sailors in isolation on their ships    together with the advent of science
           the infection claiming more than 331,000       for 30 days (trentino), which was later     and technology propelled by the war,
           lives. As countries gradually ease lock-       lengthened to 40 days (quarantino).5        ensured equanimity and acceptance as
           down restrictions, reports of second and       This public health concept has proven its   public health measures were applied on
           third waves are already surfacing.             effectiveness even up to the present day.   a large scale.

          06 JUN 2020 SMA News
Apollo's - Singapore Medical ...
Rain of Apollo’s arrows                           The Art of War by Sun Tzu is one of           of large-scale swab and serological
                                               the most well-known guides on military           testing to ascertain their COVID-19
Even with humankind’s experience
                                               warfare. A general from the 5th century BC,      status, and the setting up of community
with past pandemics, it remains almost
                                               Sun Tzu has been widely acknowledged as          care and recovery facilities to allow the
unfathomable how a contagion such as
                                               a master strategist. The Art of War is said to   recuperation of those infected.
a virus, measured only in nanometres,
                                               have shaped Mao Zedong’s thinking and               One may question the political
has thrown the order of life of almost         the Chinese communists’ actions against
everyone topsy-turvy.                                                                           wisdom of the State taking the lead
                                               the Japanese.9                                   at great cost, given that the majority
   With COVID-19, WFH and HBL (which                                                            of migrant workers come under the
stands for work from home and home-            The art of war is of vital importance
                                               to the State. It is a matter of life and         employment of private companies.
based learning, respectively) are now
instantly recognisable acronyms with           death, a road either to safety or to ruin.           The political will for Singapore to take
thematic associations with Singapore’s         The contemporaneous application                  these extraordinary measures is because
circuit breaker measures. Global losses        of Sun Tzu’s teaching on battle                  first and foremost, it is the right thing to
are estimated at up to USD 8.8 trillion7       preparation is to recognise that political       do. Migrant workers have contributed to
(SGD 12.5 trillion) and economic               considerations, policy decisions and             our nation building and development.
                                               ground actions are inextricably linked           Until recently, they belonged to a
repercussions have become a leitmotif
                                               and deterministic to success or failure.         segment of the workforce in Singapore’s
of a COVID-19 Black Swan event.
                                                                                                society that was not often talked about.
    In modern day Singapore and much               Singapore has long relied on migrant
                                               workers for infrastructure building and              Our Government is also keenly
of the developed world, our usually very
                                               other essential services. Today, we have         aware of the policy consideration
low mortality rates from communicable
                                               about 200,000 of them housed in 43               that without addressing the problem
diseases threw the hard truth of
                                               purpose-built dormitories, 95,000 in 1,200       of infection in the migrant worker
COVID-19 deaths into sharp relief. The
                                               factory-converted dormitories, 20,000            population, we cannot win the war
five countries with the highest number                                                          against COVID-19. Many of them work
of fatalities are all in North America and     in construction temporary quarters and
                                               85,000 in Housing and Development                in the community and share the same
Europe, with the US leading the pack. It                                                        social and recreational spaces as fellow
is a surreal situation.                        Board flats and other private residential
                                               premises across the country.10                   Singaporeans. The position statement
  Apollo, a god in the ancient Greek                                                            that Singapore has “a responsibility to
pantheon, shot arrows of plague at the            While much has been debated on                our migrant workers”12 dictated the
Greek army for nine continuous days            whether we can afford to reduce our              decisive actions that unfolded over the
because King Agamemnon captured                dependence on migrant workers,                   last couple of months.
and refused to release the daughter of         what is clear and present today is the
                                               disproportionate impact of COVID-19                  In many aspects, the “dormitory
Chryses, who was Apollo’s priest.                                                               operation” is not only a whole-of-
                                               on this group of residents in Singapore.
    Some scholars in Greek mythology           Since the first cases were diagnosed in          Government endeavour, but a whole-
have drawn a link between plagues              migrant workers in early February 2020,          of-society effort. Ultimately, Singapore
and leadership. King Agememnon’s               dormitory residents now (as at 24 May            is aware that we can overcome our
ill-considered decision resulted in            2020) account for 29,363 of 31,616 cases         current public health crisis only if our
devastating losses in his army. It was         of COVID-19 infections in Singapore.11           migrant workers, too, win the fight
said that “…he [King Agememnon] rages                                                           against COVID-19.
                                                  Close, communal living and the
with baneful mind, and knows not at all
                                               pattern of life are probably significant         If you know the enemy and know
to look both before and after…”. 8 The                                                          yourself, you need not fear the result
                                               factors in disease propagation. There
ability to understand cause and effect                                                          of a hundred battles.
                                               are countries facing the same issues
unpins the ability for effective prevention,   which compartmentalise them away and
preparation and prosecution of an                                                               Shortly after their report of atypical
                                               choose to do nothing, but Singapore is           pneumonia cases to the WHO China
operation. This is manifestly projected in     one of the few governments in the world
the management of a public health crisis.                                                       Country Office, Chinese scientists
                                               which has arguably done the most to              isolated and fully sequenced the virus in
                                               contain COVID-19 in migrant workers.             early January 2020. The gene sequencing
Sun Tzu’s stratagem
                                                  Additional housing arrangements               data was submitted to Virological.org,
Most people will agree that handling           were onboarded to de-densify living              a forum for analysis and interpretation
a public health crisis is akin to waging       quarters. Significant resources were             of virus molecular evolution and
a war against an invisible enemy.              deployed from the public and private             epidemiology. This early access was
Strategies and tactics therefore need to       healthcare sectors to ensure timely              pivotal in allowing scientists around the
be employed, overlaid by political will        access to healthcare for every migrant           world to kickstart research in diagnostics
and underpinned by unity of the people.        worker. These also include the conduct           and therapeutics.

                                                                                                                       JUN 2020 SMA News 07
Apollo's - Singapore Medical ...
from COVID-19 can be
                                                                                                        avoided if there were
                                                                                                        timely access to intensive
                                                                                                        care resources to support
                                                                                                        those with severe disease
                                                                                                        through their most critical
                                                                                                        periods of illness.
                                                                                                            Hospitals have
                                                                                                         concurrently been ramping
                                                                                                  2
 1
                                                                                                         up their intensive care
                                                                                                         capacities. Refresher
                                                                                                         training for healthcare
                                                                                           workers with previous experience in
    WHO also activated its R&D                  scientists from the National University    critical care has been conducted to
 Blueprint soon after. The Blueprint            of Singapore’s School of Public Health     scale up more teams. Ventilators, other
 improves coordination among                    has enabled us to better understand the    life support equipment and medications
 scientists, clinicians and public health       transmission dynamics and apply the        are stockpiled to enable hospitals to
 professionals in research priorities           right interventional strategies.           go into surge capacity when infections
 and the development of public health              To leverage our strengths and exploit   peak nationally.
 response standards – absolutely vital as       the enemy’s vulnerabilities is a time-        To date, Singapore’s fatality rate
 the world comes to grips with a highly         tested stratagem that applies to both      from COVID-19 stands at 0.1%, among
 infectious novel pathogen.                     conventional warfare and the non-          the lowest in the world. In comparison,
     It is estimated that from January to       conventional battleground, such as the     countries such as the UK, Italy and
 April, more than 23,000 scientific papers      COVID-19 pandemic.                         Belgium have fatality rates in excess
 on COVID-19 have been published                                                           of 13%.16
                                                The good fighters of old first put
 at a doubling time of 20 days!13 This
                                                themselves beyond the possibility             Even for our migrant worker
 is an astounding pace that left many
                                                of defeat, and then waited for an          population, generally of the young-
 “drowning in COVID-19 papers”.
                                                opportunity of defeating the enemy.        to-middle age groups and largely free
    While Singapore may be a small nation,                                                 of serious chronic diseases, additional
                                                Merely five months into the pandemic,
 we punch above our weight and are an           we are still a distance away from          measures have been put in place
 undisputed powerhouse for translational        developing an effective cure or vaccine.   to reduce morbidity and prevent
 research in biomedical sciences.               While the “enemy” is holding the           mortality. They are equipped with
     From the early days of the pandemic,       higher ground, one should bid for time,    health monitoring devices, such as
 our hospitals and research agencies            minimise unnecessary confrontations        thermometers and pulse oximeters;
 actively participated in multi-centre          and losses, and await the right            they also have round-the-clock access
 clinical trials on different modalities of     opportunity for a decisive strike.         to medical care, including after-hours
 COVID-19 treatment. We also made major                                                    telemedicine services.
                                                   Primary prevention has been the
 breakthroughs in developing the first-         mainstay of public health strategy            In the absence of effective
 in-the-world rapid COVID-19 detection          against COVID-19. Whether it is safe       therapeutics or vaccines, COVID-19
 system employing the surrogate virus           distancing, the wearing of masks or        remains a significant threat to public
 neutralisation test,14 and using serological   the practice of hand hygiene, these        health. We need to buy time for scientists
 testing to establish a link between two        measures seek to minimise infections in    to do their work. Before we reach there,
 local COVID-19 clusters.15                     the general populace, especially those     the preventive strategy is the best we
                                                from the vulnerable groups.                have in our limited armamentarium.
    In foreign worker accommodation,
 the pattern of disease spread differs             Flattening the curve is what we seek
 depending on local ecological,                 to achieve epidemiologically, which will
                                                                                           Concluding thoughts
 environmental and social factors               translate into lower peaks of infected     A Gallup poll of the most important
 specific to each dormitory. Working            cases that could otherwise overwhelm       events in the 20th century featured,
 with infectious disease modelling              our healthcare system. Many fatalities     among others, the World Wars and Neil

08 JUN 2020 SMA News
Apollo's - Singapore Medical ...
Armstrong’s 1969 historic landing on
the moon.17 Pandemics did not make                    Dr Gan is Head and Senior                      References
                                                      Consultant, Department of
it to the list. COVID-19 may just be the                                                             1. Tan A. Covid-19 caused by a ‘smart virus’ that
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                                                      Medicine at the Singapore General
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    The auntie from the nasi padang                   Hospital. He was seconded to the               at: https://bit.ly/3d161H3.
                                                      Ministry of Health (MOH) from April
store which I frequent predicted that                                                                2. Lee LY. ‘Running a marathon on the bed’:
                                                      to June 2020 and served as the MOH
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Singapore’s economy to turnaround to                  task force to manage and contain               coronavirus. Available at: https://bit.ly/3d7IS5L.
the pre-COVID-19 state. A friend, who is              the spread of COVID-19 in foreign              3. Ma J. Coronavirus: China’s first confirmed
a freelance sports coach, has not been                worker dormitories. The opinions in            COVID-19 case traced back to November 17.
working since the shutters came down                  this paper are those of the author’s           Available at: https://bit.ly/2LZNTkO.
                                                      and do not reflect the positions or
on sports halls throughout the country.               views of MOH or SingHealth.                    4. Mark JJ. Boccaccio on the black death: Text and
                                                                                                     commentary. Available at: https://bit.ly/2LXx9Lg.
    Yet, there are positives out of this.
COVID-19 has accelerated revolutionary                                                               5. History.com Editors. Black death. Available at:
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disruptive technology. My neighbour,
a lawyer, shared with me how he has                                                                  6. Billings M. The influenza pandemic of 1918.
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adapted to working from home using
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to go speedily, “Zoom” has taken on a
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    We need to get ahead of the curve in             Legend                                          9. Kuiper K. Sunzi: Chinese strategist. Available at:
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Sure, there will be new norms to adapt               migrant workers at their place of residence
                                                                                                     10. Ng JS, Ong J. The Big Read: Solving Singapore’s
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Employment landscapes will evolve.                                                                   https://bit.ly/2XsfsJ2.
However, what is immutable is the                    3. Donning personal protective equipment
                                                                                                     11. Ministry of Health, Singapore. 24 May 2020
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fortitude in the face of adversity.                  simulation training with full PPE
                                                                                                     12. Ministry of Manpower. Ministerial statement
   We will overcome.
                                                                                                     by Mrs Josephine Teo, Minister for Manpower.
                                                                                                     Available at: https://bit.ly/3c5Yzcq.

Information is accurate as at time of writing.            4                                          13. Brainard J. Scientists are drowning in COVID-19
                                                                                                     papers. Can new tools keep them afloat? Available
                                                                                                     at: https://bit.ly/36wbZgC.
                                                                                                     14. Duke-NUS Medical School. Duke-NUS,
                                                 3                                                   GenScript and A*STAR launch first-in-the-world
                                                                                                     SARS-CoV-2 serology test to detect neutralising
                                                                                                     antibodies without need of containment facility or
                                                                                                     specimen. Available at: https://nus.edu/2LXFOx8.
                                                                                                     15. Channel NewsAsia. Duke-NUS used COVID-19
                                                                                                     antibody tests to establish link between church
                                                                                                     clusters in a world-first. Available at: https://bit.
                                                                                                     ly/3c7cbUC.
                                                                                                     16. Rajendran S. Singapore’s COVID-19 death rate
                                                                                                     low, but seniors vulnerable. Available at: https://
                                                                                                     bit.ly/2ZEQoRL.
                                                                                                     17. Newport F, Moore DW, Saad L. The most
                                                                                                     important events of the century from the
                                                                                                     viewpoint of the people. Available at: https://bit.
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                                                                                                                                  JUN 2020 SMA News 09
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