BIOSTAT STR Generation 3 and BIOBRAIN Automation Platform - Commercial Manufacturing - Sartorius
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BIOSTAT STR® Generation 3 and BIOBRAIN Automation Platform Commercial Manufacturing
Engineered for Quality
and Precision
The BIOSTAT STR® Generation 3 single-use bioreactor system is now Optimize capital costs
powered by BIOBRAIN, the new automation platform with data-driven Reduce operating
Enhanced safety and expenses
software and a comprehensive suite of analytical tools. The system easily optimized space
integrates into your existing process infrastructure and consistently
delivers outstanding speed, quality, and productivity up to 2,000 L. Improve productivity and
The BIOSTAT STR® system supports the intensification of your seed ease of use
train process. Start working at lower volumes, skip one or two steps in Increase facility throughput
your seed train while still generating an adequate number of cells.
Maximize Quality and Consistency
BIOSTAT STR® system simplifies cell densities. The complete control The Sartorius scaling tool accurately
technology transfer between of the raw materials, the extrusion predicts conditions required to scale
production scales and ensures process and the bag assembly your process by considering volumes,
consistent quality without surprises guarantee consistent lot-to-lot cell process parameters, and any
and re-optimization. growth performance. The thickness, constraints to identify those process
strength and flexibility of the parameters required to achieve your
The Flexsafe STR® bags with polyethylene film enhances the goals. Our technical support team can
optimized resin formulation and mechanical robustness of Flexsafe® assist you with standard operating
minimized additive package bags, making it ideal for all biopro- procedure (SOP) conversion from
lead to cell viability and higher cessing applications. your existing scale or technology.
The BioPAT® toolbox helps you realize the full potential of intensified processing
by improving output through automated feed and bleed, better process
visibility, and by reducing risks associated with manual sampling and control.
01 BioPAT® ViaMass
In-line monitoring of viable biomass
and automated cell bleed control
03
02 BioPAT® Trace
On-line monitoring of glucose and
lactate and automated feed control
03 BioPAT® Foam
05 Monitoring of foam level with alarming
and interlock functionalities
04 Electrochemical single-use pH sensors
04 05 BioPAT® Xgas
Oxygen-carbon dioxide sensor
featuring automatic compensation of
humidity and pressure
BioPAT® Spectro
01 02
Unlock the full potential of Raman
spectroscopy
Flex Your Production
The BIOSTAT STR® system with a organizational racks for pumps options on a magnetically coupled
working volume from 12.5 L to 2000 L and balances together with cable center-line shaft that deliver
and BIOBRAIN automation platform and tubing organizers plus flexible homogenous mixtures quickly, even
provides you the flexibility and power document tray fit in perfectly. at high volumes and low mixing
to adapt on-demand. speeds.
Each bioreactor has a fully scalable,
The fully configurable control tower stirred-tank design and offers high On top of that, BIOSTAT STR® sup-
can be used interchangeably with performance across a range of ports connection to Repligen’s XCell™
any bag holder size. The advanced processes including high-cell density, ATF cell retention devices to
user interface and improved connec- micro carrier and perfusion. The increase the cell density and
tivity make bioreactor operation Flexsafe STR® bags are designed productivity and enables process
more streamlined. Furthermore, the with multiple sparger and impeller intensification.
Attain Operational Excellence
The BIOSTAT STR® system provides
different control options to let you Are you an Emerson DeltaV™ user?
- ---
choose the best integration into your Benefit from the native DeltaV™ solution.
existing process infrastructure.
Technical advantages:
Local management via control Complete mapping of your BIOSTAT® system
-
tower including BIOBRAIN Full access to all process values and controller parameters
automation platform with Sartorius DeltaV™ library to manage sensors, actors and advanced analytics
connection to data historians
Full process management via The integration for native DeltaV™ comes with local support of an experienced
distributed control systems e.g. project team which provides support from initial design to final installation.
Emerson, Siemens or Rockwell
Find out more
For more information, please visit
sartorius.com/biostat-strBIOSTAT STR® Generation 3 Configurations
Our commerical manufacturing solutions have been predesigned into three configurations
with flexible options and easy upgrades. Select the configuration that best fits your current
needs and can conveniently adapt to any future requirements.
Essential Performance Performance Plus
Perfusion ready
Process Analytical Technologies (PAT) Toolbox
BioPAT® Foam Optional Optional
BioPAT Trace
®
Optional Optional
BioPAT ViaMass
®
Optional Optional
BioPAT Xgas
®
Optional Optional
BioPAT Spectro
®
Optional Optional
Electrochemical pH sensor
Peripherals
No. of external pumps 2 4 4
Load cells
Mass flow controller 6 6 6
Flexsafe STR® bags
Sartocheck® bag tester Optional Optional
Integration Capabilities
Recipe editing and execution
Local data storage
Native Emerson DeltaV™
Siemens SIMATIC PCS 7
Process design support and services
Sales and Service Germany USA
Sartorius Stedim Biotech GmbH Sartorius Corporation
Contacts August-Spindler-Strasse 11 565 Johnson Ave.
37079 Goettingen Bohemia, NY 11716
For further contacts, visit Phone +49 551 308 0 Phone +1 631 254 4249
sartorius.com
China Singapore
Sartorius Stedim Biotech (Beijing) Co., Ltd. Sartorius Stedim Singapore Pte. Ltd.
No. 33 Yu’An Road 10 Science Park Rd
Konggang Industrial Zone B The Alpha #02-13/14 Singapore
Shunyi District Science Park II
Beijing 101300 Singapore 117684
Specifications subject to change without notice. Phone +86 10 8042 6300 Phone +65 6872 3966
Copyright Sartorius Stedim Biotech GmbH
DIR: 2577549-000-00
Status: 03 | 2020You can also read
