HA Tech 2.0 Hyaluronan: the innovative and valuable ally for multifaceted healthy-ageing approaches - ROELMI HPC
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HA Tech 2.0® Hyaluronan: the
innovative and valuable ally for
multifaceted healthy-ageing
approaches
published by srl
Via delle Azalee, 11
DR. STEFANO MASI 20147 Milano - Italy
Tel. +39 02 4120269
Product Manager, Nutraceutical Actives w w w . b5 s r l . c o m
ROELMI HPC Srl info@b5srl.com
Via Celeste Milani, 24/26
21040 Origgio VA - Italy
Over the years, consumers have become more nutraceuticals offer nowadays a wider and more
and more aware of the importance for preserving targeted range of solutions for healthy-ageing
a healthy status throughout their life span. Time and beauty from-within. Furthermore, products
never stands, and ageing has been put in the can often be combined in an In&Out approach,
spotlight by the increasing life expectancy. Due integrating beauty supplements into the
to that, “healthy-ageing” is nowadays an personal care routine, by acting to the same skin
important trend, interesting both genders. People condition through different, but complementary,
want to preserve youth and feel fully responsible mechanisms of action.
for implementing the correct actions aiming to Nutraceuticals are defined as “any substance
long-term well-being. 40’s are the new 30’s and that provides health benefits” (1). When
along with lifestyle changes and the growing overlapped with cosmeceuticals, they give rise
sense of health and science, more and more to nutricosmetics category (2). Thanks to the
consumers are looking for preventive, non- improved efficacy of cosmetic treatments and
invasive and convenient solutions to preserve further discoveries in the nutraceutical field,
youthful. nutricosmetics currently constitute a relevant
Together with beauty, healthy-ageing category among the wider nutritional
involves joint health and mobility. Indeed, more supplements family, covering the holistic
than before, people feel the need to delay the concept between healthy inner status and
signs of the time, not only reflecting a nicer beautiful outer appearance.
aspect but also enjoying an active life. Pushed by Market size of the global beauty supplements
renewed customer needs, cosmetics and is expected to exceed US$ 9B in 2026 with a
compound annual growth rate of 9.5% per year
(3), with the top 3 regional markets represented
by Japan, China and interestingly Italy (4).
18 Additionally, even the global bone and joint
supplements market is projected to grow and to
JULY/AUGUST 2020
overcome US$ 5 Billion by 2025, with a leading to purest grades (9). Typically used in
significant momentum for joint segment (5). medications, cosmetics and food, HA is widely
Markets forecasts highlight the expected spread in human soft tissues and is present at
ascending trend of healthy ageing sector. different molecular weights (MW) (10). Due to its
Nutricosmetics will offer solutions to satisfy new high polarity, HA is characterized by high
demanding customers’ expectations, providing viscoelasticity, biocompatibility, hygroscopicity
treatments, easy to integrate in daily personal and water retention capacity and is biologically
care routine and with remarkable results involved in several cellular processes, such as
achievable in the short time. differentiation, proliferation, development,
Skin health products are based on different migration and cell-cell recognition (11). In addition,
biologically active compounds, selected for their the macromolecule is even involved in
beneficial impact in counteracting ageing, inflammatory, tissue repair and wounds healing
reconstituting extra-cellular matrix (ECM) and processes (12).
protecting tissues from oxidants. Therefore, For its ability to replenish moisture in the skin,
nutricosmetics for healthy-ageing have to due to its water retention capacity, and
stimulate fibroblasts, leading to hyaluronans considering its endogenous collagen synthesis
(HA), collagen and elastin endogenous promotion, as the result of dermal fibroblasts
production, and to protect from reactive oxygen stimulation, HA is a key ingredient in
species (ROS) denaturising effects. Years of nutricosmetics. Indeed, it is reported to have
researches brought to a series of actives antioxidant effects and to improve skin hydration,
effective in preserving skin properties and smoothness and elasticity, together with
treating wrinkles. Considering skin ECM wrinkles and deep lines formation slowdown (13).
fundamental constituent, the first choice is HA More than 10 years ago, considering
administration. Further nutricosmetics to scientific literature reporting HA to be present in
support skin beauty from-within are collagen, the the body as molecules with different MW and
major insoluble fibrous protein of the ECM, thanks to evidences collected about precise HA
together with vitamin C, retinoids and MW responsible for specific physiological
tocopherols, supporting collagen synthesis (6) processes and physio-chemical properties (11),
and exerting antioxidant effects (7). Moreover, Roelmi HPC started working on a new concept,
botanical extracts (e.g. Aloe vera sterols) that resulted in HA Tech 2.0® and Full Spectrum
integration could support skin health and Hyaluronans (14).
rejuvenation. Finally, omega-3 and omega-6 The Full Spectrum Technology consists in a
intake could lead to a healthier skin repairing fine modulation with defined steps for the bio-
epidermis lipid layers, thus preventing water loss fermentation process, where precise variations
(7) and decreasing skin roughness (8). of temperature, pressure and time are
HA is a linear, flexible, high molecular mass implemented. The obtained HA molecules are
natural polysaccharide, belonging to then finely processed to obtain a specific
glycosaminoglycans, consisting of alternating spectrum (a fingerprint of peaks referred to
disaccharide monomers of N-Acetyl-D- different MW) of hyaluronans, with a MW range
glucosamine and D-glucuronic acid, joined by varying from 20 to 3000 kDa. Despite standard
b-1,4 and b-1,3 glycosidic bonds. Generally called sodium hyaluronate and HA obtained through Full
hyaluronan, in humans HA is present as sodium, Spectrum Technology are the same both from a
calcium, magnesium or potassium hyaluronate chemical and physical point of view, these two
salts, with polar groups that make the type of hyaluronans are characterized by
macromolecule able to bind water. Initially
obtained from animal sources (e.g. rooster
19
comb), HA is nowadays produced by bacterial
fermentation of Streptococcus zooepidemicus,
JULY/AUGUST 2020
al. (17). Even
Kajimoto et al. (18)
showed the results
of a daily
administration of
HA on skin
hydration,
reporting a
significant
increase, but only
after 6 weeks of
administration and
Figure 1. with a high dosage.
completely different MW-related patterns: Furthermore, several studies are open-label (19,
standard HA shows a narrow distribution peak, 20) and often lacking of a control group,
while HA Tech 2.0® profile results in a complex consequently resulting in lower outcomes
fingerprint, characterized by a range of specific solidity.
peaks reflecting a wider array of MW (Figure 1). Considering the scarce evidences from
Roelmi HPC’s technology allows to obtain a previous studies on the effects of traditional HA
complex of MWs that work synergistically as it from animal or bacterial origin, Roelmi HPC carried
happens normally in the body, allowing a subtler
modulation of physiological processes if
compared with what HA molecules could play
with single MW.
Considering that HA content in the skin of a
75-years-old person is lower than one-quarter if
compared with that of a 19-year-old subject, the
need of HA supplementation is evident to cover
HA deficiency (15). Literature shows a lack of
data on bioavailability and consistent efficacy
evidences for the oral intake of HA with
anti/healthy-ageing purpose. In fact, only few
studies reported that ingested HA obtained
through bio-fermentation processes positively
affects skin health, but nutricosmetics out a human study to clinically assess the
requirements of efficacy and quickness of improved effect on skin health and ageing of
results are rarely fully matched. Indeed, Oe et al. ExceptionHYAL® Star, an oral supplement based
(16) reported the results of the 12 weeks on HA Tech 2.0®, after a short administration
administration of HA on wrinkles reduction, period (28 days). Thanks to a greater affinity with
showing active efficacy, but with moderate cell receptors, Full Spectrum HA is designed to
results. The lack of significant differences versus closely meet the composition of soft tissues in
placebo after 6 weeks of oral administration of human body (e.g. skin, mucosa, synovial fluid,
HA was then reported, for example, by Kawada et cartilage), originating a richer pattern of building
block to self-regenerate endogenous HA and
improving cell metabolism promoting elastin
synthesis.
20
The RDBPC clinical trial confirmed the
efficacy of ExceptionHYAL® Star, thanks to Full
JULY/AUGUST 2020
Spectrum HA, which mimics the physiological MW nutraceuticals, and cosmeceuticals. Journal of
pattern, promoting as a rheostat the regulation cosmetic dermatology, 11(1), 51-54.
3) Credence Research.
of internal tissue processes and homeostasis. In
4) Euromonitor.
only 28 days, skin profilometry of treated
5) Global Bone and Joint Health Supplements Industry
subjects resulted significantly improved, with
– Global Industry Analysts - Feb 2020.
reduced wrinkles depth and volume. Furthermore, 6) Borumand M, Sibilla S. Daily consumption of the
greater skin hydration, elasticity and firmness collagen supplement Pure Gold Collagen® reduces
were recorded, and even trans epidermal water visible signs of aging. Clinical interventions in aging.
loss (TEWL) resulted lowered. Positive effects of 2014;9:1747.
the specific spectrum of HA MWs are supposed 7) Khare N, Khare P, Yadav G. Recent advances in anti-
aging–a review. Glob. J. Pharmacol.
to be due to the different HA fragments
2015;9(3):267-71.
supplying cell processes and making cells able to
8) Sibilla S, Godfrey M, Brewer S, Budh-Raja A,
react in a more microenvironment-sensitive
Genovese L. An overview of the beneficial effects
manner. Self-assessment questionnaire of hydrolysed collagen as a nutraceutical on skin
performed by treated subjects allowed to properties: Scientific background and clinical studies.
confirm ExceptionHYAL® Star efficacy and The Open Nutraceuticals Journal. 2015 Feb 27;8(1).
treatment safety and compliance (21). 9) Liu L, Liu Y, Li J, Du G, Chen J. Microbial production of
A further RDBPC clinical trial was carried out hyaluronic acid: current state, challenges, and
perspectives. Microbial cell factories. 2011
to assess the efficacy of a different Full
Dec;10(1):99.
Spectrum HA-based product. ExceptionHYAL ®
10) Kawada C, Kimura M, Masuda Y, Nomura Y. Orally
Jump, Roelmi HPC’s targeted solution to
administered hyaluronan affects skin dryness and
counteract osteoarthritis (OA) progression and epidermal thickening in photoaged hairless mice.
improve joint health and quality of life in subjects Bioscience, biotechnology, and biochemistry. 2016
with knee OA symptoms, confirmed its positive Jun 2;80(6):1192-5.
role in improving pain, joint functionality and 11) Gupta, R. C., Lall, R., Srivastava, A., & Sinha, A.
stiffness and in reducing NSAIDs use (22, 23). (2019). Hyaluronic acid: Molecular mechanisms and
therapeutic trajectory. Frontiers in Veterinary
Both market and consumers are developing a
Science, 6, 192.
higher sensus of scientific awareness,
12) Cyphert, J. M., Trempus, C. S., & Garantziotis, S.
pretending more sophisticated formulations and
(2015). Size matters: molecular weight specificity
innovative technologies to comply with the of hyaluronan effects in cell biology. International
busiest lifestyle, ensuring clinically journal of cell biology, 2015.
demonstrated long term efficacy. Taking the 13) Bukhari SN, Roswandi NL, Waqas M, Habib H, Hussain
distances from standard hyaluronan and focusing F, Khan S, Sohail M, Ramli NA, Thu HE, Hussain Z.
on the reproduction of biological mechanism Hyaluronic acid, a promising skin rejuvenating
biomedicine: A review of recent updates and pre-
naturally occurring in our body, HA Tech 2.0 ®
clinical and clinical investigations on cosmetic and
technology from Roelmi HPC represents the
nutricosmetic effects. International journal of
innovative nutricosmetics solutions for healthy-
biological macromolecules. 2018 Dec 1;120:1682-95.
ageing, paving the way to a wide portfolio of 14) Masi, S., The 2.0 Full Spectrum Hyaluronans
targeted products for beauty from-within and Technology to improve bioavailability and efficacy
joint health applications. performance, Agro Food Industry Hi-Tech, 2020.
15) Oe M, Mitsugi K, Odanaka W, Yoshida H, Matsuoka R,
Seino S, Kanemitsu T, Masuda Y. Dietary hyaluronic
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a novel hydrolyzed chicken sternal cartilage
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