IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA

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IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
IMPACT OF SARS-CoV-2 ON
CARDIOVASCULAR DISEASES
                  Gianfranco Parati

  Dept of Medicine and Surgery, University of Milano-Bicocca
 Dept of Cardiovascular, Neural and Metabolic Sciences, St. Luca
          Hospital, Istituto Auxologico Italiano, IRCCS,
                          Milan, Italy
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
DISCLOSURES
          Gianfranco Parati

No confict of interest in relation
          to this topic
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
COVID-19 and Cardiovascular Diseases

1. Direct Impact of SARS-CoV-2 on Cardiovascular
   System
2. Impact of COVID-19 on CV Diseases
   Management
3. Role of Telemedicine for CV Patients Care.
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
COVID-19 and Cardiovascular Diseases

1. Direct Impact of SARS-CoV-2 on Cardiovascular
   System
2. Impact of COVID-19 on CV Diseases
   Management
3. Role of Telemedicine for CV Patients Care.
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
Possible Mechanisms of Acute Cardiac Injury in COVID-19
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
Cardiovascular complications in COVID-19

Lulu Ma, et al. Coronavirus Disease-2019 (COVID-19) and Cardiovascular Complications. Journal of Cardiothoracic and
Vascular Anesthesia DOI: 10.1053/j.jvca.2020.04.041
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
Spectrum of cardiovascular syndromes and echocardiographic abnormalities in patients with
COVID-19 infection.

Capotosto L, et al. Heart, COVID-19, and echocardiography. Echocardiography. 2020;00:1–11.
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
IMPACT OF SARS-COV-2 ON CARDIOVASCULAR DISEASES - GIANFRANCO PARATI DEPT OF MEDICINE AND SURGERY, UNIVERSITY OF MILANO-BICOCCA
COVID-19 thromboembolic complications
                                                               DECT. Multiple iodine map
                                                               “perfusion defects” in a case of
                                                               CTEPH (white stars). Note also
                                                               an increased RV:LV ratio with
                                                               mild paradoxical bowing of the
                                                               interventricular septum (black
                                                               arrows).

R. McStay et al. / Clinical Radiology 76 (2021) 74.e1e74.e14
JACC: BASIC TO TRANSLATIONA L SCIENCE VOL. 6, NO. 3, 2021 Canzano et al.
MARCH 2021:202 – 218   COVID-19: Platelet and Endothelial Activation
COVID-19 and Cardiovascular Diseases

1. COVID-19 and Cardiovascular Patients Care in
    Milano
2. Direct impact of SARS-CoV-2 on Cardiovascular
   System
3. Impact of COVID-19 on CV Diseases
   Management
4. Role of Telemedicine for CV Patients Care.
Social Isolation
  No Access to
Cardiology Clinics
Cardiac Ultrasounds Test performed in Heart
Failure Patients - Lombardy Region
Courtesy of G.Corrao and F.Rea

                                                1,0                                                                                               0,0020
Proporzione di pazienti senza ecocardiogramma

                                                                                                              Hazard del primo ecocardiogramma
                                                0,9
                                                                                                                                                  0,0015

                                                0,8
                                                                                                                                                  0,0010
                                                0,7

                                                                                                                                                  0,0005
                                                0,6

                                                0,5                                                                                               0,0000
                                                      0         100          200          300          400                                                0          100          200            300         400
                                                 gen      feb   mar   apr     mag   giu    lug   ago    set                                             gen   feb   mar    apr    mag     giu    lug   ago    set
                                                                        dic-19      dic-18                                                                                 dic-19       dic-18

                                                                                                                                                 2020

                                                                                                                                                 2019
Clinic Cardiology Consultation of Hypertensive
Patients under Antihypertensive Treatment -
Lombardy Region
Courtesy of G.Corrao and F.Rea
                                         1,0                                                                                          0,0012
  Proporzione di pazienti senza visita

                                                                                                         Hazard della prima visita
                                         0,9
                                                                                                                                      0,0008

                                         0,8

                                                                                                                                      0,0004
                                         0,7

                                         0,6                                                                                          0,0000
                                               0         100            200           300         400                                         0         100         200          300         400
                                          gen      feb   mar   apr       mag   giu    lug   ago    set                                      gen   feb   mar   apr   mag    giu   lug   ago    set
                                                                     2020      2019                                                                            2020       2019

                                                                                                                                     2020

                                                                                                                                     2019
Proportion of Hypertensive Patients with an
Antihypertensive Drug Available - Lombardy
Region
Courtesy of G.Corrao and F.Rea
                                                              0,85
     Proporzione di pazienti con un farmaco antiipertensivo

                                                              0,80

                                                              0,75
                                                                   0     30    60    90   120     150    180    210
                                                                gen    feb    mar   apr   mag      giu    lug    ago

                                                                                           2020

                                                                                           2019
COVID-19 and Cardiovascular Diseases

1. COVID-19 and Cardiovascular Patients Care in
    Milano
2. Direct impact of SARS-CoV-2 on Cardiovascular
   System
3. Impact of COVID-19 on CV Diseases
   Management
4. Role of Telemedicine for CV Patients Care.
TELEMEDICINE
               AT THE TIME OF COVID-19
• Need of maintaining continuous link with patients unable
  to come to Cardiology or Hypertension clinics for regular
  visits and checks

• Need to reassure on safety of ongoing antihypertensive
  and cardiovascular treatment

• Importance of counseling and empowerment through
  remote connection

• Importance of data teletransmission

• -> Home BPM combined with telemonitoring and tele-
  consultations
• -> Role of Digital Health and Mobile Health
“ESH-CARE” app
 • Storage and graphs of
   BP and anthropometric
   data
 • Link to Doctor
 • Education
 • Research
 • ESH centres location
1 year                         1            Lockdown
                         before                         month
                                                        before
Uncontrolled BP

Unstable BP

Controlled BP

                  HOME BLOOD PRESSURE DURING COVID-19 RELATED LOCKDOWN
                              IN PATIENTS WITH HYPERTENSION
                                       Pengo M, Parati G et al.
                                Eur.J.Prev.Cardiology 2021, in press
Moving back from lockdown darkness to light
and health

Milano, Italy
Istituto Auxologico Italiano, IRCCS, Ospedale
San Luca, Milano.
                                                gianfranco.parati@unimib.it

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