Poster Presentation Day 2 - OMICS International
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1816th Conference
Annual Cardiology 2018
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018| Atlanta, Georgia, USA
Poster Presentation
Day 2
Page 49
Xiaojing Zhao, J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Perilipin1 deficiency in whole body or bone Marrow-Derived cells attenuates lesions in
atherosclerosis-prone mice
Xiaojing Zhao
Chinese PLA General Hospital
Aims: The objective of this study is to determine the role of perilipin 1 (Plin1) in whole body or bone marrow-derived cells on
atherogenesis.
Methods and Results: Accumulated evidence have indicated the role of Plin1 in atherosclerosis, however, thesefindings are
controversial. In this study, we showed that Plin1 was assembled and colocalized with CD68 in macrophages in atherosclerotic
plaques of ApoE-/- mice. We further found 39% reduction of plaque size in the aortic roots of Plin1 and ApoE double
knockout (Plin1-/-ApoE-/-) females compared with ApoE-/- female littermates. In order to verify whether this reduction
was macrophage-specific, the bone marrow cells from wild-type or Plin1 deficient mice (Plin1-/-) were transplanted into
LDL receptor deficient mice (LDLR-/-). Mice receiving Plin1-/- bone marrow cells showed also 49% reduction in aortic
atherosclerotic lesions compared with LDLR-/- mice received wild-type bone marrow cells. In vitro experiments showed
that Plin1-/- macrophages had decreased protein expression of CD36 translocase and enhanced cholesterol ester hydrolysis
upon aggregated-LDL loading, with unaltered expression of many other regulators of cholesterol metabolism, such as cellular
lipases, and Plin2 and 3. Given the fundamental role of Plin1 in protecting LD lipids from lipase hydrolysis, it is reasonably
speculated that the assembly of Plin1 in microphages might function to reduce lipolysis and hence increase lipid retention in
ApoE-/- plaques, but this pro-atherosclerotic property would be abrogated on inactivation of Plin1.
Conclusion: Plin1 deficiency in bone marrow-derived cells may be responsible for reduced atherosclerotic lesions in the mice.
Biography
Xiaojng zhao, MD, PhD, She is the researcher of Chinese PLA General Hospital and her main research direction is heart disease and atherosclerosis . She has
published more than 10 papers in reputed journals.
xjingzhao@126.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 50Vivianne Chandrakesuma et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Safety of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial
fibrillation after PCI: Evidence-based case report
Vivianne Chandrakesuma1 and Muhadi2
1
Universitas Indonesia, Indonesia
2
Cipto Mangunkusumo National Hospital, Indonesia
Introduction & Aim: Atrial Fibrillation (AF) patients undergoing coronary stenting require both anticoagulant and antiplatelet
for prevention of thrombosis and stroke. The standard triple therapy with vitamin K antagonist and Dual Antiplatelets Therapy
(DAPT) reduces risk of stroke and thrombosis but carries high bleeding risk. Non-vitamin K Antagonist Oral Anticoagulants
(NOACs) has proved to significantly reduce risk of bleeding in AF patients with similar efficacy to warfarin. Therefore, this
report aims to learn whether NOACs lead to lower rates of bleeding compared to warfarin in AF patients after PCI.
Method: A literature search was performed using PubMed, Cochrane Library and Ovid databases. Studies were included if
they are written in English, published within the last 5 years, and are meta-analysis, RCTs, clinical trials or systematic review.
The search resulted in 188 articles and two articles were considered eligible. The articles were critically appraised for their
validity, importance and applicability.
Result: In PIONEER-AF PCI trial, rivaroxaban 15 mg plus P2Y12 inhibitor and rivaroxaban 2.5 mg plus DAPT showed
significantly lower rates of major and minor bleeding compared to warfarin DAPT. RE-DUAL PCI trial showed dabigatran
(110 mg and 150 mg) plus P2Y12 inhibitor led to significantly lower rates of major, clinically relevant nonmajor and total
bleeding.
Conclusion: Antithrombotic therapy with NOACs (Rivaroxaban 15 mg, Dabigatran 110 mg and 150 mg) plus P2Y12 inhibitor
or Rivaroxaban 2.5 mg plus DAPT can be considered for AF patients after PCI as opposed to the standard triple therapy
considering their lower rates of bleeding.
Biography
Vivianne Chandrakesuma is currently a 5th year Medical Student from University of Indonesia. She has completed her Bachelor of Medicine from University of
Indonesia and Bachelor of Medical Science from University of Melbourne, Australia.
vivianne.ch@hotmail.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 51Jiacheng Sun et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Targeted therapy using engineered mesenchymal stem cells-derived exosomes for myocardial infarction
Jiacheng Sun, Zhenya Shen and Junjie Yang
Soochow University, China
E xosomes are membranous vesicles generated by almost all cells. Recent studies demonstrated that MSCs derived exosomes
possessed many effects including anti-apoptosis, anti-inflammatory, stimulation of angiogenesis, anti-cardiac remodeling
and recovery of cardiac function on cardiovascular diseases. However, targeting of exosomes to recipient cells precisely in
vivo still remains a problem. Ligand fragments or homing peptides discovered by phage display and in vivo bio-panning
methods fused to the enriched molecules on the external of exosomes have been exploited to improve the ability of exosomes
to target specific tissues or organs carrying cognate receptors. It is briefly elucidated that effective targeting of exosomes to
ischemic myocardium can be achieved by engineering exosomal enriched membrane protein (Lamp2b) fused with a peptide
motif CSTSMLKAC (IMTP). In vitro results showed that IMTP-Exos could be internalized by hypoxia injured H9C2 cells
more efficiently than Blank-Exos. Compared with Blank-Exos, IMTP-Exos was observed to be increasing accumulated in
ischemic heart area (PDanish Abbasi et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Rare cardiac manifestation of a commonly prescribed drug: Takotsubo cardiomyopathy caused by
allopurinol induced Dress Syndrome
Danish Abbasi, Hina Mannan, VineshKumar Patel and Syed Farhan Hasni
Atlanti Care Regional Medical Center, USA
T akotsubo syndrome from allopurinol has been rarely reported. Our case is unusual presentation of stress induced
cardiomyopathy from allopurinol induced dress syndrome. We present a case of 42-year-old male with history of chronic
kidney disease stage with rash, itching and swelling. Two weeks before he was started on allopurinol for hyperuricemia.
Examination showed swelling of face, extremities with diffuse papular rash. Temperature was 99.3°F, BP 122/93, RR 18.
Blood work showed worsening renal function (Cr 3.10), transaminitis (LDH 184, AST 104, ALT 136) and eosinophilia of
13.6%. RegiSCAR score of 6 was highly suggestive of Dress Syndrome. Patient’s allopurinol was discontinued. Patient was
started on steroids and showed improvement. Patient returned three weeks later with chest pain and shortness of breath. BP
110/68, pulse rate 132, respiratory rate 30 breaths/min, Sat O2 87%.CK-MB 30 and troponin 10. Eosinophil count 19%. EKG
showed sinus tachycardia and diffuse ST elevation. Emergent cardiac catheterization showed no coronary artery disease, severe
LV systolic dysfunction with apical dilation. Ejection fraction was 20% (EF of 55-60%- baseline). Findings were consistent
with Takotsubo Cardiomyopathy (TS). He was continued on steroids and lasix. Skin biopsy showed superficial perivascular
dermatitis. Subendocardial biopsy showed mild perivascular and subendocardial infiltrates not suggestive of active eosinophilic
myocarditis. Patient condition stabilized and EF improved to 45-50%. He was discharged on prednisone taper. DRESS syndrome
is rare, potentially life-threatening hypersensitivity reaction. Early recognition is important as it has associated mortality of
10%. European Registry (RegiSCAR) is the most commonly used diagnostic criteria. Drug induced Takotsubo cardiomyopathy
is mostly associated with medication causing direct or indirect catecholamine stimulation. Although a common association
with Dress Syndrome, allopurinol induced Takotsubo cardiomyopathy is extremely rare. We aim to highlight the importance of
clinical suspicion for takotsubo cardiomyopathy in patients with new onset heart failure treated with allopurinol that remains
a common prescription medication.
Biography
Danish Abbasi is currently working as a Hospitalist in AtlantiCare Regional Medical Center, NJ. He is involved with Internal Medicine Residency Program and
currently part of Residency Teaching Faculty. He has been appointed as Clinical Assistant Professor (Adjunct) in the Lewis Katz School of Medicine at Temple
University, Department of Medicine. My area of interest is Cardiology and I hope to pursue a cardiology fellowship for 2019.
danisheperwaiz@gmail.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 53Aaon Nana Frimpong, J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Risks and causes of heart failure in our contemporary world
Aaon Nana Frimpong
Cyprus International University
W hen a thrombus forms within an artery, this is known as an arterial thrombosis. Clot formation is typically triggered
by the rupture of an atherosclerotic plaque, a highly thrombogenic event, with platelets rapidly recruited to the site.
The fibrin content of the clot slowly increases as the thrombus extends into the arterial lumen. Thus, an arterial thrombus is
typically platelet-rich, fast growing and exposed to fast blood flow. AF-related thrombi are also categorized as arterial clots,
but more closely resemble ‘venous-type’ clots, fulfilling Virchow’s triad for thrombogenesis. AF-related thrombi form in low-
flow, low-pressure environments, producing slow-growing, fibrin-rich clots. Important risk factors for arterial thrombosis
include: (1) Smoking (2) Obesity (3) High blood pressure (4) Increased levels of cholesterol (5) Diabetes (6) Increasing age
(7) Family history (8) Physical inactivity (9) Increased concentrations of blood coagulation factors and (10) Blood serum
lipid abnormalities. Incidence and prevalence in thrombogenesis is atherosclerotic lesions develop throughout the arterial
system and, depending on the vascular bed most affected, disease can manifest as CAD, PAD or cerebrovascular disease. CAD
is the most commonly diagnosed form of cardiovascular disease, in which atherosclerosis damages the coronary artery wall
predisposing to thrombus formation. The symptoms and severity of ACS (unstable angina and MI) vary depending on the
degree to which thrombi occlude the coronary arteries.The incidence and prevalence of the clinical manifestations of arterial
thrombosis is high. The annual incidence (number of new and recurrent cases per year) of symptomatic or fatal MI and
stroke in the US has been estimated to be 915,000 and 795,000, respectively. Estimates place the overall prevalence of MI in
the US at 7.6 million and stroke at 6.8 million. Complications include arterial-type clots can result in MI and unstable angina
(ACS events), ischaemic stroke and some manifestations of PAD, such as acute limb ischaemia. Thrombi characteristics are an
important consideration for the development of treatment/prevention strategies (i.e. anticoagulant/antiplatelet).
Biography
Aaon Nana Frimpong is currently studying his Master’s from Cyprus International University.
aarongymmy@yahoo.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 541816th Conference
Annual Cardiology 2018
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018| Atlanta, Georgia, USA
e-Poster Presentations
Page 55Cynthia L Murray, J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Preventing fetal programming of cardiovascular diseases: Insights from the stories of pregnant
women gaining weight above national guidelines
Cynthia L Murray
Memorial University of Newfoundland, Canada
Background & Aim: Research on fetal programming of chronic diseases demonstrates that cardiovascular diseases (CVDs)
have roots in prenatal life. For instance, higher maternal gestational weight gain before 36 weeks of gestation is associated with
greater adiposity and adverse cardiovascular risk factors in the offspring. Prevalence rates of high gestational weight gain are
steadily increasing in many countries, including the United States and Canada. From 2000-2009, 44% of American pregnant
women gained above the Institute of Medicine (IOM) recommendations, with a biennial 0.8% point increase in women gaining
above IOM recommendations. Little qualitative research has been conducted to investigate pregnant women’s perspectives
and experiences of high gestational weight gain. The purpose of this hermeneutic phenomenological study was to explore the
meaning and experience of weight gain for pregnant women with high gestational weight gain.
Method: In-depth interviews were conducted with seven pregnant women from St. John’s, Newfoundland and Labrador,
Canada who gained more weight than medically recommended according to Health Canada/IOM guidelines. In order to
examine a lived experience in-depth, phenomenological studies have a sample size of 6-10 participants. The data were analyzed
using van Manen’s method of hermeneutic phenomenology.
Findings: The themes in the data indicated that the women swiftly gained weight and were caught off guard by their high
weight gains. They were confused about their weight gain status because they received contradictory messages from their
health care providers. They perceived their weight gain as being outside of their control and resorted to hoping for healthy
pregnancy outcomes.
Conclusion: The participants painted a picture of helplessness in their accounts of high gestational weight gain. Recommendations
for health care professionals are made to support pregnant women in gaining within the IOM guidelines.
Biography
Cynthia L Murray is an Associate Professor in the School of Nursing at Memorial University of Newfoundland in St. John’s, Canada. She obtained her PhD in
Nursing from the University of Alberta and both her Bachelor of Nursing degree and Master of Nursing degree from Memorial University. She conducts quantitative,
qualitative and mixed methods research. Her qualitative methodological expertise is in phenomenology, particularly hermeneutic interpretive phenomenology based
on the philosophical underpinnings of Heidegger, Ricoeur and Gadamer. She has extensive experience in community health nursing.
cindym@mun.ca
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 56Saeed Razaq et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
LVSD in high risk patients with acute myocardial infarcation
Saeed Razaq, Khudija Nayab, Dave Whitfield and Sara Fadali
Kabir Medical College of Medicine, Pakistan
Aim: The aim of this study was to determine the frequency of Left Ventricular Systolic Dysfunction (LVSD) following an acute
ST Segement Elevation Myocardial Infarction (STEMI) in patients with cardiovascular disease risk factors such as gender,
increasing age, smoking, hypertension, diabetes, obesity and dyslipidemia.
Method: This study was conducted in the department of cardiology, Hayatabad Medical Complex, Peshawar from March
2014-August 2014. Through a descriptive cross sectional study design, a total of 379 high risk patients of acute Myocardial
Infarction (MI) were included in the study in a consecutive manner and subjected to echocardiography to detect LVSD under
informed consent and approval from the hospital ethical and research committee.
Result: Of the 379 patients in this study 56.3% were males and 43.8% were females. The mean age of the patients was 52.2 years
with a standard deviation of 8.08 years. 57.3% were smokers, 52.8% were Hypertensive (HTN), 43% were diabetics, 23.5% were
classed as obese and 53.8% had dyslipidemia. 37.7% of these patients were found to have LVSD after echocardiography.
Conclusion: LVSD has an occurence rate of greater than 1/3 in people with a meang age of 52.2 years, favoring slightly more
men than women with cardiovascular disease risk factors, who have suffered a STEMI.
Biography
Saeed Razaq recieved his Bachelor of Medicine and Bachelor of Surgery at Kabir Medical College in Peshawar, Pakistan. He has completed a Residency in
Internal Medicine and Cardiology at Hayatabad Medical Complex. Upon completion of USMLE examinations he has embarked upon multiple research projects,
attended several workshops in research methodology, biostatistics and dissertation writing in collaboration with World Health Organization along with volunteereing
in flood releif and raising awarness for polio vaccine in Pakistan.
saeedrazaq@live.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 57Benoit Coutu et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
From clinical trials to general cardiology practice: How many patients could benefit from each
NOAC?
Benoit Coutu1, Jean G Diodati2, Katia Dyrda3 and Jean-François Roux4
1
Centre Hospitalier Universitaire de Montréal, Canada
2
Hôpital du Sacré-Coeur de Montréal-Université de Montréal, Canada
3
Montreal Heart Institute-Université de Montréal, Canada
4
Centre Hospitalier Universitaire de Sherbrooke, Canada
Statement of the Problem: The availability of Novel Oral Anticoagulants (NOACs) has caused a paradigm shift in non-Valvular
Atrial Fibrillation (NVAF) management over the last few years. Clinical trials and evidence-based medicine are growing. New
indications and/or new data from different patient profiles are becoming available. The goal of this study was to evaluate how
many patients, evaluated through a general cardiovascular clinic, could benefit from a treatment with a NOAC (apixaban,
dabigatran, edoxaban and rivaroxaban) based on the data available and on the patient’s medical conditions.
Methodology & Theoretical Orientation: The main inclusion/exclusion criteria from completed and ongoing phase III-IV
clinical trials were identified for each NOAC from the source clinicaltrials.gov. Data forms were completed for 103 consecutive
patients seen in a general cardiology ambulatory clinic and statistical analysis was performed to evaluate the proportion of
patient who could theoretically benefit from each NOAC.
Findings: Out of 103 patients, 33 (32%) could benefit from apixaban, dabigatran or edoxaban vs. 65 patients (63%) from
rivaroxaban (pHaitham Mazek et al., J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Takotsubo cardiomyopathy and Atrial Myxoma, is there association.
Haitham Mazek, Nandini Nair
Texas Tech University Health Sciences Center, Lubbock, Texas.
T akotsubo cardiomyopathy is characterized by transient LV dysfunction, EKG changes that can mimic acute myocardial
infarction (MI), and minimal release of myocardial enzymes in the absence of obstructive coronary artery disease. A
72-year-old active female with history of hypothyroidism presented with acute onset of nausea, vomiting, and diarrhea started
one day. She presented to ER and received 2 L of intravenous fluid. She then developed acute shortness of breath while in
the ER. Chest exam revealed crackles both sides. Initial labs remarckable for Troponin 0.22 and BNP 898. Initial EKG shows
no ST elevations, or depressions. Chest x-ray showed mild interstitial edema. Patient was treated with diuretic and started
on ACS protocol for possible acute coronary syndrome. She underwent LHC shows normal coronary arteries with severe
depression of systolic function with ejection fraction 21% Regional wall motion: Hypokinesia of the mid ventricle and apex
with hypercontractile basilar segments consistent with Takotsubo cardiomyopathy. Transthoracic echocardiography revealed
ejection fraction 35-39%. RV apical segment sever hypokinetic, global hypokinesis, and mobile echogenic mass in left atrium
5.5 x 2.2 attached to intra-arterial septum consistent with left atrial myxoma. Patient underwent surgery 8 days later and
myxoma was removed. Patient was doing well and discharged home. Her TTE repeated 4 months later and showed significant
improvement of LVEF 65-69% with no regional wall motion abnormalities. Takotsubo cardiomyopathy is typically preceded
by exposure to emotional or physical stressors, although in some cases, precipitant stressors have not been identified. Cardiac
myxomas, although rare, are the most common, primary benign tumors of the heart. They occur more frequently in women
commonly between the ages of 30 and 60. In our case report, patient was diagnosed with atrial myxoma which could be one of
participating factors, reviewed literature showed only 2 cases reports with same presentation like our case.
Biography
Dr Mazek has graduated from Texas Tech University Health Sciences Center; currently he is Assistant Professor with department of family medicine at Texas Tecch
University Health Sciences Center, Lubbock, Texas and working as Academic Hospitalist. Dr Mazek interest is in cardiology.
Haitham.Mazek@ttuhsc.edu
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 591816th Conference
Annual Cardiology 2018
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018| Atlanta, Georgia, USA
Accepted Abstracts
Page 60J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Simulation based learning for cardiac residents and fellows
Sawsan Al Yousef
King Saud Bin Abdulaziz University, Saudi Arabia
M edical simulations aim to imitate real patients, anatomic regions, clinical tasks, virtual reality devices and electronic manikins or
to mirror real-life situations in which medical services are rendered. Simulation-Based Learning (SBL) applies these modalities.
Benefits of medical simulation includes safe environment, mistake forgiving, trainee focused vs. patient focused, controlled,
structured, proactive clinical exposure, reproducible, standardized, debriefing, deliberate and repetitive practice. Medical simulation
can assess professional competence as patient care, medical knowledge, practice-based learning & improvement, communication
skills, professionalism and systems-based practice. Patient safety priorities are at the forefront of health providers concerns. The see
one, do one, teach one philosophy certainly should be eliminated. This is best summarized by “simulators have the potential to take the
early and dangerous part of the learning curve away from patients”. Simulation has rapidly evolved as a learning tool and technology
over the past 15 years, and has been shown to be an effective method for teaching. Despite this, the field of cardiovascular medicine is
still in the primitive stages of adopting simulation. The reasons cited for this include: the high cost of simulators, a dearth of didactic
curricula to accompany the psychomotor skill learned on a simulation, the wide variability and/or lack of consistency that exists
among the simulation platforms, and a complete absence of large trials showing that this expensive technology actually improves
operators' skill in the angiography suite and presumably enhances patient outcomes. Despite all this, the ACGME now mandates
that cardiovascular fellowship training programs must have simulation as part of fellow training. Cardiac simulation training ranges
from as simple as training on listening to normal and abnormal heart sounds, differentiating different types of heart murmurs,
interpreting ECG findings, utilizing high fidelity manikins for different cardiac scenarios such as heart failure and cardiogenic shock
apply team work as crew resource management, practicing transthoracic echocardiogram plus Trans Esophageal Echo (TEE), cardiac
catheterization and central line insertion up to different cardiac interventional procedures. On 2016, we conducted a survey for
pediatric and adult cardiac residents whom had attended different cardiac simulation courses at CRESENT, KFMC. We received
130 responders. 100% of the candidates found these courses are enjoyable, safe, not stressful and very useful training methods, 98%
enjoyed it mostly because it is repetitive and mistakes are forgiven with zero hazards to patients.100% feels video briefing following
cardiac medical scenarios is very helpful as it clarify areas for improvement much better than conventional training. In conclusion,
although cardiac Simulation courses is expensive but it plays important role in patient safety so at the end it is cost effective so would
encourage to make it mandatory in the curriculum for cardiac residents and fellows.
sawsan_35@hotmail.com
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 61J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes using various
preconditioning strategies
Asmat Salim, Irfan Khan, Anwar Ali, Kanwal Haneef, Nadia Naeem, M Aleem Akhter and Hana’a Iqbal
University of Karachi, Pakistan
C ardiovascular Diseases (CVDs) are the number one cause of death globally. According to WHO, an estimated 17.7 million
people die annually from CVDs, representing 31% of all global deaths. One of the major cardiovascular disorders is Myocardial
Infarction (MI), during which cardiomyocytes have limited self-renewal capacity and therefore, their functional ability is compensated.
Conventional therapies offer limited improvement in terms of cardiac function. Cell based therapeutics with the potential of cardiac
regeneration, hold significant promise as an alternative therapeutic approach. Mesenchymal Stem Cells (MSCs) are considered as one
of the best candidates for cellular therapy because of their immense potential in the regenerative medicine and tissue engineering.
However, large number of transplanted MSCs does not survive in the ischemic environment of the infracted heart with inadequate
blood supply and increased inflammation. To ensure the survival of engrafted stem cells, a number of preconditioning strategies
have been adopted including hypoxic shock and genetic modifications using growth factors. We used 2, 4, Dinitrophenol (DNP)
for hypoxia and a number of cell survival, angiogenic and cardiomyogenic growth factors for genetic modification of MSCs. These
preconditioned MSCs were transplanted in the rat model of myocardial infarction. Cardiac function was assessed by echocardiography
while histological analysis was performed to analyze reduction in the fibrotic region. Promising results were obtained in case of these
modifications and significant improvement in the cardiac function was observed. In this talk, potential role of preconditioned MSCs
on cardiac differentiation will be highlighted.
asmat.salim@iccs.edu
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 62J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Impact of hospital management process re-engineering on patients with ST segment elevation myocardial
infarction: A single center experience of China-Japanese union hospital of Jilin University
Bohan Xiao
Jilin University, China
C hina-Japan Union Hospital of Jilin University (CJUH) is located in the center of Jilin Province, Northeast of China. As one of the
central affiliation hospitals attached to the national health and family planning commission of the people’s republic of China, CJUH
receives patients with high critically illness in the whole province and the annual inpatients and outpatients 119,859 and 1,612,413
(in 2016) respectively. While the number of patients with cardiovascular diseases accounts a large proportion (41,000 inpatients,
120,000 outpatients). Therefore, in order to find a quick and reliable management process, CJUH has experienced unprecedented
changes gradually during the recent five years. Firstly, after one-year preparatory work, in January 2015, CJUH successfully set up
Chest Pain Center (CPC) via the authentication of China Chest Pain Center. According to statistics analysis with data of patients with
ST-segment-elevation myocardial infarction (STEMI) in CPC during 2015, 2016 and 2017 (up to July), average time of Symptom-On
To First Medical Contact (SO-FMC), First Medical Contact To Balloon (FMC2B), cardiogram to diagnosis time, door to balloon
time (D2B) and hospital days decreased with statistical significance. Secondly, considering ambulances in the city are dispatched
by Municipal First-Aid Center (MFAC) for the past few decades that cause a long Pre-Hospital-Transferring Delaying Time (PDT).
Therefore, August 2017, an emergency station allocated with ambulances was set up and all emergency personnel are taken alternating
shifts by CJUH staff, in order not only to decrease SO-FMC and PDT, yet to have better cooperation between pre-and in-hospital
treatment.
ELLLLLLLLLLE@hotmail.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 63J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
50 cases of surgical repair of VSD and their short term outcome
Kazi Zahidul Hoque1, Makbul Hossein1, Ashik Imon1and Devprasad Baishnab2
1
Dhaka Shishu Hospital, Bangladesh
2
Northern International Medical College, Bangladesh
Background & Aim: Ventricular Septal Defect (VSD) is the commonest congenital cardiac anomaly in Bangladesh. For this reason,
patch repair of VSD is commonly performed cardiac surgery here. The aim is to observe the short term outcome of patch repair of
VSD.
Method: 50 consecutive patients were enrolled in the study by purposive sampling who received treatment for isolated VSD in
Department of Pediatric Cardiac Surgery of Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. They underwent VSD patch
repair from January to December, 2017. A prospective observational cross-sectional study was conducted for this 12 months
period. A pre-structured, interview and observation based, peer reviewed data collection sheet was prepared. Data regarding socio-
demographic, clinical-surgical and outcome profile were recorded. Data were compiled, edited and analyzed with SPSS version 23.
Data were presented as mean and standard deviation, frequency percentage and median with range.
Result: The mean birth weight of 50 patients was 2.8 kg (range: 2.1-3.5 kg) whereas the median of gestational age was 38 weeks.
Among these 50 patients, 22 (44%) and 28 (56%) were boys and girls respectively. The only indication of surgery was volume load.
Out of 50 patients, 46 (92%) had peri-membranous variety. On the contrary, 4 (8%) experienced double committed type of VSD. The
mean bypass time and aortic cross-clamp time were recorded as 70±13.7 minutes and 35±6.85 minutes respectively. Out of 50 patients
who underwent PTFE patch repair, 2 (4%) experienced pneumothorax, 1 (2%) got chylothorax and 1 (2%) had transient heart block.
Total 45 (90%) patients showed uneventful outcome.
Conclusion: Contemporary results of PTFE patch repair in case of VSD showed unparalleled outcome with extremely low morbidity
in our perspective.
debubaishnab@gmail.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 65J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
The association between cardiorespiratory fitness and physical activity levels of central obese adults in
Enugu state (eastern part), Nigeria
Iwezu Happy Nonso
University of Nigeria-Nsukka, Nigeria
C entral obesity and its implicated adverse health conditions are a major concern of some people. Central obesity is one of the
predisposition factors to cardiovascular disease, respiratory conditions, type-II diabetes mellitus, cancer and others. The purpose
of this study was to determine the relationship between central obesity, cardio respiratory fitness and physical activity level among
adults in Enugu State. Three hundred and seventeen subjects (158 obese and 159 non-obese) who met the inclusion criteria and gave
their informed consent participated in the study. Their waist to hip ratio was determined using measuring tape. Body Mass Index
measured with stadiometer and weighing scale. Cardio respiratory fitness was determined using Harvard Step Test and International
Physical Activity Questionnaire (IPAQ) was used to determine their physical activity level. Data collected was analyzed descriptively
and inferentially using correlation test. The level of significance was set at p=0.01. The physical activity level of obese adults in Enugu
state increases in an ascending order of vigorous, low, moderate while the cardiorespiratory fitness decreases in reverse direction
as low, average, good, excellence and very low. There was a significant relationship between cardio respiratory fitness and physical
activity (r=0.146, sig=0.009). There was also a significant relationship between waist-hip ratio and cardiorespiratory fitness (r=-0.221,
sig=0.000). The discussion will be on the effect of central obesity on cardio-respiratory fitness and physical activity on adults and its
pathophysiology.
iwezuhappy@yahoo.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 66J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Detection of cardiac arrest using deep learning for automated external defibrillator
Minh Tuan Nguyen and Kiseon Kim
Gwangju Institute of Science and Technology, South Korea
V entricular Fibrillation (VF) and Ventricular Tachycardia (VT), known as shockable rhythms, are the main cause of Sudden
Cardiac Arrests (SCA), which can be properly treated by electronic defibrillators. Recently, Convolutional Neural Networks
(CNN) has emerged as a useful approach. Moreover, CNNs are also used to extract a set of informative features, which is then used
as the input of the Machine Learning (ML) classifiers. Here, we use two databases, which are the Creighton University Ventricular
Tachyarrhythmia Database (CUDB) and the MIT-BIH Malignant Ventricular Arrhythmia Database (VFDB), divided into training and
testing sets. Firstly, the CNNs and CNN-extractor models are selected on training data using fully CNNs and CNNs in combination
with ML classifiers. Then, the fully CNNs and set of feature extracted by CNN-extractor are validated on the testing data. Therefore,
the performance of fully CNNs and CNN-extractor is investigated to construct a novel algorithm, which can be effectively applied for
the Automated External Defibrillators (AEDs).
nguyenminhtuan@gist.ac.kr
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
Page 67J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
The role of Dobutamine dose on the cardiac parameters
Rabindra Nath Das
University of Burdwan, India
Introduction: The report presents the effects of dobutamine dose on the cardiac parameters such as blood pressures (basal, systolic,
diastolic and maximum), heart rates (basal, peak and maximum), baseline cardiac ejection fraction and ejection fraction on
dobutamine dose. There is a little literature about the effects of dobutamine dose on the cardiac parameters.
Method: The effects of dobutamine dose on the cardiac parameters have been examined based on a real echocardiography stress data
set, collected at University of California, Los Angeles on 558 patients with 31 explanatory variables/factors. The distribution of the
considered cardiac parameters is gamma with non-constant variance. So, they have been analyzed by joint generalized linear gamma
models.
Result: The mean Basal Blood Pressure (BBP) decreases as the double product of maximum Heart Rate (MHR) and Maximum Blood
Pressure (MBP) at Dobutamine Dose (DPMAXDO) (PJ Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C7-108
25th Annual Congress on
Cardiology and Medical Interventions
July 16-17, 2018 | Atlanta, Georgia, USA
Diabetic keto acidosis as a deceiving presentation to simultaneous aortic and tricuspid infective endocarditis
V P Rambhujun1, J Ciancerelli1, R Daggubati1 and D Silber2
1
NYU Winthrop Hospital, USA
2
Columbia Medical Centre, USA
I nfection remains a common cause for DKA, though its association with endocarditis is rare. The incidence of Infective Endocarditis
(IE) ranges between 1.5-1.6 per 100 000 prosthetic valve endocarditis occurs in 1-6% of patients and rarely is it bilateral, as this
case is. 71 year old female patient admitted with diabetic ketoacidosis and low grade fevers. She had an infectious work up in which
the blood cultures grew streptococcus mitis. The patient, subsequently, had a transthoracic echocardiogram that was negative for
any vegetation’s; but considering the fact that she had a prosthetic valve and she was persistently bacteremic, she underwent a TEE
that showed simultaneous aortic (bio prosthetic valve) and tricuspid infective endocarditis. The patient was treated conservatively
with surgery being the next step if she didn’t improve. She improved astoundingly rapidly with IV antibiotics. This case is interesting
because our patient had vegetation’s on both side of the heart which is very rare. We were able to find only two such cases; the first
was an IV drug user with persistent bacteremia and the second patient had a Ventricular sepal defect with aortic and tricuspid
endocarditis. There are too few reported cases of patients with right and left endocarditis to have guidelines for management of such
patients. We opted for a non-surgical management of our patient in view of her comorbidities with surgery as the option if she did
not improve. Our case is probably the only case of simultaneous two valve endocarditis was managed conservatively with the patient
making a complete recovery, making it a unique case.
Vikash_rambhujun@hotmail.com
Notes:
Journal of Clinical and Experimental Cardiology | ISSN: 2155-9880 | Volume 9
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