Presentation General A newly-approved safe ingredient for effective weight management - Hermes Consilium
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General Presentation A newly-approved safe ingredient for effective weight management
Table of contents
Designed for consumers
Scientific evidence
Regulatory status
Technological data
Marketing potential
Conclusion
2
Designed for consumers
Designed for consumers
What is Chromax®?
A newly-approved safe ingredient for effective
weight management promotion
Chromax® is a patented form of the nutritional mineral
chromium (Cr3+) and tri-picolinic acid, known as chromium picolinate.
Chromax® is made from pure compounds using proprietary
manufacturing and quality control processes to produce a superior
high purity product.
Some other chromium products on the market actually contain
less than 70% pure chromium picolinate.
Chromax® is the only chromium picolinate approved by the EU. Its
high purity and safety testing makes it superior to other chromium
products on the market.
4
Designed for consumers
Chromax®: A safe and effective
solution you can rely upon
Superior chromium bioavailability and efficacy
The bioavailability of Chromax® has been clinically
demonstrated as significantly better compared to other
sources of chromium.
Chromax® has been clinically demonstrated as a safe and
effective product in over 15 published studies.
Consumers now have a higher confidence that Chromax®
matches the high quality standards used in the efficacy
studies performed over the last 15 years.
On the weight management market, consumers are often eager to find
more reliable solutions . Indeed, they often need to choose between
safety or efficacy: When they choose Chromax®, consumers are ensured
have both a safe and efficient weight management solution.
5
Scientific evidence
Scientific evidence
Chromax®: Clinically proven efficacy
More than 15 clinical studies on over 1,800 volunteers
Chromax®: increased chromium absorption and
bioavailability
2 scientific studies on chromium concentration in urine
1 scientific study on chromium concentration in tissues
Chromax®: carbohydrate metabolism regulation
More than 15 clinical studies on insulin sensitivity and glucose regulation
Chromax®: weight management promotion
4 clinical studies on weight and fat mass loss
1 clinical study on satiety
1 clinical study on carbohydrate craving
7Scientific evidence
Chromax®: Clinically proven efficacy
Increased chromium absorption & bioavailability
1. Stability and absorption of different 2. Comparison of acute absorption of
forms of chromium chromium supplements
(N=6, 48hrs, 200 mcg Cr, Chromax® 1.6 mg/day) (N=12, 24hrs, 200 mcg Cr, Chromax® 1.6 mg/day)
2500
600
* pScientific evidence
Chromax®: Clinically proven efficacy
Increased chromium bioavailability
Dietary chromium effects on tissue
chromium concentrations and chromium
absorption in rats 50
45
Subjects: 55 male Wistar rats
ng/mg dry weight
40
Duration: 3 weeks 35
30
Dosage: 5 µg/g of diet/day of pure chromium, under 25
the form of chromium chloride, chromium nicotinate 20
or chromium picolinate (Chromax®, 0.04 mg/g of 15
diet/day) 10
5
Chromax® is significantly more concentrated in 0
liver, muscle and heart than chromium nicotinate Liver Muscle Heart
and chromium chloride Control CrCl CrNic CrPic
Anderson et al., 1996
These studies demonstrate a significant difference in chromium
bioavailability between Chromax® and other sources of chromium
9Scientific evidence
Glucose Metabolism,
Insulin Resistance & Disease
Genetics Weight Lack of Medications Deficiencies
Gain Exercise
Impaired Glucose Metabolism
“Insulin Resistance”
Muscle & Fat Brain
Cognitive
Obesity
Impairment
Diabetes CVD
Cravings Depression
10Scientific evidence
Chromax®: Clinically proven efficacy
Carbohydrate metabolism regulation
Chromax® potentiates insulin function for a clinical
proven action on carbohydrate metabolism
Chromax® enhances the activity of insulin receptors on
cells membranes and thus increases insulin sensitivity and
glucose storage in muscle cells
Chromax®, by promoting healthy blood sugar metabolism,
reduces the storage of fat and contributes to healthy weight
management
11Scientific evidence
Chromax®: Clinically proven efficacy
Carbohydrate metabolism regulation
Enhancement in Insulin Sensitivity in Healthy
Volunteers following supplementation with
Chromium Picolinate
• Volunteers: 6 healthy subjects
• Duration: 10 weeks
• Dosage: 1.6 mg/day of Chromax®, equivalent
to 200 µg/day of pure chromium
Results:
• Significant increase of fasting levels of plasma
chromium during the 5 first weeks
• Fasting Blood glucose levels tends to decrease Morris et al., 1998
during the supplementation
Chromax® significantly reduces insulin resistance at the dosage of 1.6 mg/day
Chromax® significantly decrease fasting Insulin at the dosage of 1.6 mg/day
12Scientific evidence
Chromax®: Clinically proven efficacy
Carbohydrate metabolism regulation
Others studies on insulin sensitivity and glycemic regulation.
At the dosage of 200µg of chromium per day, 5 clinical studies showed significant results:
Study Volunteers Duration Dosage(1) Results
Lucidi, 2005 10 with PCOS(3) 4 months 1.6 mg (200 µg) glucose tolerance
Ghosh, 2002 50 type 2 diabetics with 3 months 1.6 mg (200 µg) glycated hemoglobin(2) (*pScientific evidence
Chromax®: Clinically proven efficacy
Weight management promotion/Fat mass loss
Effects of chromium picolinate supplementation on
body composition. Kaats et al., 1998.
Volunteers:
• 154 mixed volunteers
• Inclusion criteria: overweight or obese (mean BMI = 30)
Duration: 72 days
Dosage: 1.6 to 3.3 mg/day of Chromax®, equivalent to 200 to 400 µg/day of pure
chromium
14Scientific evidence
Chromax®: Clinically proven efficacy
Weight management promotion/Fat mass loss
Effects of chromium picolinate supplementation on body composition
Weight loss (kg) Fat mass loss (kg) Lean mass loss (kg) Fat mass loss (% body weight) BCI (kg)
8
6 ***
4
**
2
0
-2
-4
* *** * ***
-6
* Placebo 1.6 mg/day of Chromax® 3.3 mg/day of Chromax®
BCI (Body Composition Index) = net difference between lean mass gain and fat mass loss
*pScientific evidence
Chromax®: Clinically proven efficacy
Weight management promotion/Satiety
Effects of chromium picolinate on food intake and satiety.
After 1 week After 8 weeks
Volunteers: 400
350
• 42 women
Food intake reduction (kcal)
300
• Inclusion criteria: BMI 25-40, 250
reporting intense carb craving 200
150
100
Duration: 8 weeks 50
0
Dosage: 8.3 mg/day of Chromax® Placebo Chromax®
equivalent to 1000 µg/day of
chromium Anton et al., 2008.
Chromax® significantly reduces food intake at the dosage of 8.3 mg/day
16Scientific evidence
Chromax®: Clinically proven efficacy
Weight management promotion/ Carbohydrate craving
Exploratory trial of chromium picolinate in atypical depression:
effect on carbohydrate craving
Volunteers:
0 2 weeks 4 weeks 6 weeks 8 weeks
2
• 75 mixed volunteers 1.8
• Inclusion criteria: experiencing 1.6
1.4
atypical depression
1.2
Hunger
Score
1
0.8 Carb craving
Duration: 8 weeks 0.6
0.4
0.2
Dosage: 5 mg/day of Chromax®, 0
equivalent to 600 µg/day of Docherty et al., 2005.
chromium
Chromax® significantly decreases hunger and carb craving from the dosage of 5 mg/day
17Scientific evidence
Chromax®: Clinically proven efficacy
Conclusions
Chromax® has greater absorption of chromium and increased
bioavailability in scientifically validated studies that have been
approved by regulatory authorities worldwide
Chromax® as « chromium picolinate is among the most bioavailable forms of chromium »
(The EFSA Journal (2009) 1113, 1-41)
Chromax® has clinically proven efficacy on the regulation of
carbohydrate metabolism at the dosage of 2 mg/day
Chromax® is a safe and effective ingredient for success in your
weight management products
18Regulatory status
Regulatory status
Is Chromax® authorized for use?
A clear and well-defined regulatory status
A food grade ingredient
Europe*:
• The only Authorized form of chromium picolinate
for use in foodstuffs for particular nutritional uses and foods
intended for the general population (including food supplement)
(The EFSA Journal 2010;8(12):1882)
• Recommended dosage according to the current national regulations
USA:
• Authorized for use in food supplements
• Chromax is the only chromium picolinate authorized
for use in functional bars and beverages;
Generally Recognized as Safe (GRAS status)
Asia:
• Authorized for use in food supplements in most countries: Australia, Indonesia, Malaysia,
Singapore, Taiwan, Thailand,…
• Authorized for use in functional foods in most countries:
Indonesia, Singapore, Taiwan, Thailand,…
20Regulatory status
Is Chromax® authorized for use?
A clear and well-defined regulatory status
A health claim authorization
FDA approval for a qualified health claim regarding the
reduction of risk of insulin resistance and type II diabetes
A clear label
Suggested labeling: « Chromium picolinate » (« Picolinate de chrome »)
Chromax® benefits from our regulatory expertise.
Please feel free to contact us for further information.
21Technological data
Technological data
How can Chromax® be used?
A flexible ingredient
Chromax® is a fine and homogeneous powder. It is
red colored, water-soluble and pH-stable.
Thanks to its high density and to its low dosage (2 mg/day), Chromax® can easily be
implemented into various matrices:
• Food supplements: tablets, capsules, softgels, gums,…
• Functional foods: bars, dairies, chocolate, beverages,…
Several applications have already been tested.
Please feel free to contact us for further information.
Chromax® is a ready-to-use ingredient that will make the
difference in your food supplement or functional food
23How can Chromax® be used?
Recommended dosage
In adherence with WHO (World Health Organisation) and EFSA
conclusions, Hermes Consilium recommends a dosage of 2 mg/day of
Chromax®, which is equivalent to 240 µg/day of pure chromium
The WHO and EFSA concluded that pure chromium is safe up to 250
µg/day and has validated Chromax® as a safe form of chromium
For consumer, only 2 mg/day of Chromax® will provide you with
all the benefits of chromium without any concern for safety
24Marketing potential
Marketing potential
Chromax®: Successful in applications
One bioactive for multiple applications!
Chromax® shot A Newly-Approved Safe Ingredient for Effective Weight
Management. Chromax® is the first chromium picolinate that meets the high
quality standards required in the EU. Chromax® potentiates insulin function for a
clinically proven action on carbohydrate metabolism and weight management
Glycemia optimize Helps you control blood sugar level.
Chromax® acts on the moderation of glucose metabolism by enhancing the
activity of insulin. With optimized glycemic regulation, you can eat the
food you like without concern for poor glucose control.
Fit&Slim Speed’up your metabolism. FIT&SLIM is a drink designed for
people who want to get slim by adding a weight manage system to their
regular physical activity. Chromax® stimulates carbohydrate and fat
metabolism and enables development of a firm, fit and slim body.
26Chromax®: Successful in applications
One bioactive for multiple applications!
Eat Less Helps you reach a healthy diet naturally. Eat less is an original
formulation composed of specific high-end chromium picolinate: Chromax®. It has
a double action both on physical satiety and on hormonal signals. This delicious
beverage allows you to experience satiety and reduce your food intake, in order to
reach you the silhouette of your dreams.
Stop snacking Control food craving for a successfull diet Snacking is the
first cause of failure during long-time diet. Thanks to its exclusive ingredient
Chromax®, which act on the carbohydrate metabolism, Stop snacking will help you
get the strength to resist temptation and achieve a successful diet.
Chromax® BMR (Body Mass Reduction) Your partner for an athletic
body With Chromax®, lose your fat mass while preserving your muscular one.
Coupled with an intense physical activity, Chromax® BMR will help you get rid of
excess body fat without sacrificing your muscles.
27Conclusion
Conclusion
Why choose Chromax®?
The most effective at the best price
The purest and the safest chromium picolinate
on the market of the chrome products
Clinically proven Chromax® is the quality
efficacy on carbohydrate reference and has high
metabolism regulation, safety compared to other
increased bioavailability, products
and weight management Chromax®
Chromax® established its
Easy implementation in dietary proof of efficacy though
supplements and food matrices numerous clinical studies
The best value for money
of the market!
29Hermes Consilium, a reliable partner Blaž Gorjup Managing director (E) info@hermes-consilium.com (W) www.hermes-consilium.com Hermes Consilium d.o.o. Valjhunova 11, SI-1000 Ljubljana, Slovenia (T) +386 1 434 5678 (F) +386 1 430 6649
Conclusion
References
Anderson, R.A. ; Bryden, N.A. ; Polansky, M.M. ; Gautschi, K. (1996). Dietary chromium effects on
tissue chromium concentrations and chromium absorption in rats. The Journal of Trace Elements in
Experimental Medicine ; 9 ; 11-15.
Anderson, R.A. ; Cheng, N. ; Bryden, N.A. ; Polansky, M.M. ; Chi, J. ; Feng, J. (1997). Elevated
intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2
diabetes. Diabetes ; 46 ; 1786-1791.
Anderson, R.A. ; Polansky, M.M. ; Bryden, N.A. (2004). Stability and absorption of chromium and
absorption of chromium histidinate complexes by humans. Biological Trace Element Research ; 101 ;
211-218.
Anton, S.D. ; Morrison, C.D. ; Cefalu, W.T. ; Martin, C.K. ; Coulon, S. ; Geiselman, P. ; Han, H. ;
White, C.L. ; Williamson, D.A. (2008). Effects of chromium picolinate on food intake and satiety.
Diabetes Technology and Therapeutics ; 10(5) ; 405-412.
Bahadori, B. ; Wallner, S. ; Hacker, C. ; Boes, U. ; Komorowski, J.R. ; Wascher, T.C. (1999).
Effects of chromium picolinate on insulin levels and glucose control in obese patients with type-II
diabetes mellitus. Diabetes ; 48 ; A349.
Cefalu, W.T. ; Bell-Farrow, A.D. ; Stegner, J. ; Wang, Z.Q. ; King, T. ; Morgan, T. ; Terry, J.G.
(1999). Effect of chromium tripicolinate on insulin sensitivity in vivo. The Journal of Trace Elements
in Experimental Medicine ; 12 ; 71-83.
31Conclusion
References
Cheng, N. ; Zhu, X. ; Shi, H. ; Wu, W. ; Jiamin, C. ; Jianying, C. ; Anderson, R.A. (1999). Follow-
up survey of people in China with type 2 diabetes mellitus consuming supplemental chromium. The
Journal of Trace Elements in Experimental Medicine ; 12 ; 55-60.
DiSilvestro R.A. ; Dy, E. (2007). Comparison of acute absorption of commercially available
chromium supplements. The Journal of Trace Elements in Medicine and Biology ; 21 ; 120-124.
Docherty, J.P. ; Sack, D.A. ; Roffman, M. ; Finch, M. ; Komorowski, J.R. (2005). A double-blind,
placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on
carbohydrate craving. Journal of Psychiatric Pratice ; 11(5) ; 302-314.
Evans, G.W. (1989). The effect of chromium picolinate on insulin controlled parameters in humans.
Int. J. Biosocial. Med. Res. ; 11 ; 163-180.
Feng, J ; Lin, D. ; Zheng, A. ; Cheng, N. (2002). Chromium picolinate reduces insulin requirement
in people with type 2 diabetes mellitus. Diabetes ; 51 ; A469.
Ghosh, D. ; Bhattacharya, B. ; Mukherjee, B. ; Manna, B. ; Sinha, M. ; Chowdhury, J. ;
Chowdhury, S. (2002). Role of chromium supplementation in Indians with type 2 diabetes mellitus. J.
Nutr. Biochem. ; 13 ; 690-697.
Jovanovic-Peterson, L. ; Gutlerrez, M. ; Peterson, C.M. (1999). Chromium supplementation for
women with gestational diabetes mellitus. The Journal of Trace Elements in Experimental Medicine ;
12 ; 91-97.
32Conclusion
References
Kaats, G.R. ; Blum, K. ; Fisher, J.A. ; Adelman, J.A. (1998). Effects of chromium picolinate
supplementation on body composition: a randomized, double-masked, placebo-controlled study. Current
Therapeutic Research ; 57(10) ; 747-756.
Lucidi, R.S. ; Thyer, A.C. ; Easton, C.A. ; Holden, A.E.C. ; Schenken, R.S. ; Brzyski, R.G. (2005).
Effect of chromium supplementation on insulin resistance and ovarian and menstrual cyclicity in women
with polycystic ovary syndrome. Fertil. Steril. ; 84 ; 1755-1757.
Lydic, M.L. ; McNurlan, M. ; Bembo, S. ; Mitchell, L. ; Komaroff, E. ; Gelato, M. (2006). Chromium
picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome. Fertil. Steril. ;
86 ; 243-246.
Martin, J. ; Wang, Z.Q. ; Zhang, X.H. ; Wachtel, D. ; Volaufova, J. ; Matthews, D.E. ; Cefalu, W.T.
(2006). Chromium picolinate supplementation attenuates body weight gain and increases insulin
sensitivity in subjects with type 2 diabetes. Diabetes Care ; 29(8) ; 1826-1832.
Morris, B.W. ; Kouta, S. ; Robinson, R. ; MacNeil, S. ; Heller, S. (2000). Chromium supplementation
improves insulin resistance in patients with type 2 diabetes mellitus. Diabet. Med. ; 17 ; 684-685.
Rabinovitz, H. ; Leibovitz, A. ; Madar, Z. ; Gabai, G. ; Habot, B. (2000). Blood glucose and lipid
levels following chromium supplementation in diabetic elderly patients on a rehabilitation program.
Gerontologist ; 40.
33Conclusion
References
Ravina, A. ; Slezak, L. ; Rubal, A. ; Mirsky, N. (1995). Clinical use of the trace element chromium
(III) in the treatment of diabetes mellitus. The Journal of Trace Elements in Experimental Medicine ; 8 ;
183-190.
Ravina, A. ; Slezak, L. ; Mirsky, N. ; Bryden, N.A. ; Anderson, R.A. (1999). Reversal of
corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet. Med. ; 16 ; 164-167.
Vrtovec, M. ; Vrtovec, B. ; Briski, A. ; Kocijancic, A. ; Anderson, R.A. ; Radovancevic, B. (2005).
Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus.
American Heart Journal ; 149(4) ; 632-636.
Wang, Z.Q. ; Qin, J. ; Martin, J. ; Zhang, X.H. ; Sereda, O. ; Anderson, R.A. ; Pinsonat, P. ; Cefalu,
W.T. (2007). Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to
chromium supplementation. Metabolism ; 56 ; 1652-1655.
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