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                   Front Matter: Volume 12035

                                  , "Front Matter: Volume 12035," Proc. SPIE 12035, Medical Imaging 2022:
                                  Image Perception, Observer Performance, and Technology Assessment,
                                  1203501 (20 April 2022); doi: 10.1117/12.2638123

                                  Event: SPIE Medical Imaging, 2022, San Diego, California, United States

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PROGRESS IN BIOMEDICAL OPTICS AND IMAGING
                                                                                                                          Vol. 23 No. 51

                   Medical Imaging 2022
                   Image Perception, Observer
                   Performance, and Technology
                   Assessment
                   Claudia R. Mello-Thoms
                   Sian Taylor-Phillips
                   Editors

                   20–24 February 2022
                   San Diego, California, United States

                   21–27 March 2022
                   Online

                   Sponsored by
                   SPIE

                   Cooperating Organizations
                   American Association of Physicists in Medicine
                   International Foundation for Computer Assisted Radiology and Surgery
                   Medical Image Perception Society (United States)
                   Radiological Society of North America
                   Society for Imaging Informatics in Medicine (United States)
                   World Molecular Imaging Society

                   Published by
                   SPIE
                                                                                                                     Volume 12035

                                                                Proceedings of SPIE, 1605-7422, V. 12035

                                 Medical Imaging 2022: Image Perception, Observer Performance, and Technology Assessment, edited by
                                            Claudia R. Mello-Thoms, Sian Taylor-Phillips, Proc. of SPIE Vol. 12035, 1203501
                                                         · © 2022 SPIE · 1605-7422 · doi: 10.1117/12.2638123

                                                                        Proc. of SPIE Vol. 12035 1203501-1
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The papers in this volume were part of the technical conference cited on the cover and title page.
                                   Papers were selected and subject to review by the editors and conference program committee.
                                   Some conference presentations may not be available for publication. Additional papers and
                                   presentation recordings may be available online in the SPIE Digital Library at SPIEDigitalLibrary.org.

                                   The papers reflect the work and thoughts of the authors and are published herein as submitted. The
                                   publisher is not responsible for the validity of the information or for any outcomes resulting from
                                   reliance thereon.

                                   Please use the following format to cite material from these proceedings:
                                   Author(s), "Title of Paper," in Medical Imaging 2022: Image Perception, Observer Performance, and
                                   Technology Assessment, edited by Claudia R. Mello-Thoms, Sian Taylor-Phillips, Proc. of SPIE 12035,
                                   Seven-digit Article CID Number (DD/MM/YYYY); (DOI URL).

                                   ISSN: 1605-7422
                                   ISSN: 2410-9045 (electronic)

                                   ISBN: 9781510649453
                                   ISBN: 9781510649460 (electronic)

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                                        The last two digits indicate publication order within the volume using a Base 36 numbering
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Contents

                               vii       Conference Committee

                                        ARTIFICIAL INTELLIGENCE

                     12035 03           Developing interactive computer-aided detection tools to support translational clinical
                                        research [12035-12]

                     12035 04           Assessment of manual and automated intracranial artery diameter measurements [12035-13]

                     12035 05           Analyzing neural networks applied to an anatomical simulation of the breast [12035-14]

                     12035 06           Using virtual clinical trials to determine the accuracy of AI-based quantitative imaging
                                        biomarkers in oncology trials using standard-of-care CT [12035-15]

                     12035 07           Interpretable deep learning models for better clinician-AI communication in clinical
                                        mammography [12035-16]

                                        IMAGE PERCEPTION I

                     12035 08           Investigating reading strategies and eye behaviours associated with high diagnostic
                                        performance when reading digital breast tomosynthesis (DBT) images [12035-1]

                     12035 09           Satisfaction of search (SOS) error and new lesions identification on imaging in central review
                                        for clinical trials [12035-4]

                                        MODEL OBSERVERS

                     12035 0A           Optimizing model observer performance in learning-based CT reconstruction [12035-6]

                     12035 0B           A deep Q-learning method for optimizing visual search strategies in backgrounds of dynamic
                                        noise [12035-7]

                     12035 0C           Individualized and generalized learner models for predicting missed hepatic metastases
                                        [12035-8]

                     12035 0D           Investigating the limited performance of a deep-learning-based SPECT denoising approach:
                                        an observer-study-based characterization [12035-11]

                                                                                                                                    iii

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OBSERVER PERFORMANCE AND ROC METHODS

                     12035 0E           Identical-test Roe and Metz simulation model for validating multi-reader methods of analysis
                                        for comparing different radiologic imaging modalities [12035-17]

                     12035 0F           Sequestration of imaging studies in MIDRC: a multi-institutional data commons [12035-18]

                     12035 0G           MATLAB toolbox for ROC analysis of multi-reader multi-case diagnostic imaging studies
                                        [12035-19]

                     12035 0H           Diagnostic performances of radiology trainees in reading digital breast tomosynthesis and the
                                        synthesized view [12035-20]

                     12035 0I           Visual grading characteristic (VGC) analysis of uterine artery embolisation (UAE) image quality
                                        assessment by interventional radiologists and interventional radiographers [12035-21]

                     12035 0J           Using reader disagreement index as a tool for monitoring impact on read quality due to reader
                                        fatigue in central reviewers [12035-22]

                                        MONDAY MORNING KEYNOTES

                     12035 0K           In between are the doors of perception (Keynote Paper) [12035-500]

                                        TECHNOLOGY ASSESSMENT

                     12035 0L           Breast density distribution among the Saudi screening population and correlation between
                                        radiologist visual assessment and two automated methods [12035-23]

                     12035 0M           No-gold-standard evaluation of quantitative imaging methods in the presence of correlated
                                        noise [12035-24]

                     12035 0N           Assessment of boundary discrimination performance in a printed phantom [12035-25]

                     12035 0O           Evaluating procedures for establishing generative adversarial network-based stochastic image
                                        models in medical imaging [12035-26]

                                        TRANSLATION OF CAD-AI METHODS TO CLINICAL PRACTICE: ARE WE THERE YET? JOINT SESSION
                                        WITH CONFERENCES 12033 AND 12035

                     12035 0P           Is this good enough? On expert perception of brain tumor segmentation quality [12035-29]

                     12035 0Q           Wait-time-saving analysis and clinical effectiveness of computer-aided triage and notification
                                        (CADt) devices based on queueing theory [12035-30]

                iv

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IMAGE PERCEPTION II

                     12035 0R           The reliability of radiologists' first impression interpreting a screening mammogram [12035-31]

                     12035 0S           Test-set training is linked to increased breast screening cancer detection rates [12035-32]

                     12035 0T           Experience does not protect against missed incidental-findings in radiology [12035-33]

                                        POSTER SESSION

                     12035 0U           Comparison of performance in breast lesions classification using radiomics and deep transfer
                                        learning: an assessment study [12035-35]

                     12035 0V           Case-based repeatability and operating point variability of AI: breast lesion classification
                                        based on deep transfer learning [12035-36]

                     12035 0W           Assessment of a new CAD-generated imaging marker to predict risk of having
                                        mammography-occult tumors [12035-37]

                     12035 0X           Low-dose CT denoising via CNN trained using images with activation map [12035-38]

                     12035 0Y           AI-based analysis of radiologist’s eye movements for fatigue estimation: a pilot study on chest
                                        X-rays [12035-39]

                     12035 0Z           Comparison of deep learning architectures for COVID-19 diagnosis using chest X-ray images
                                        [12035-40]

                     12035 10           A task-informed model training method for deep neural network-based image denoising
                                        [12035-41]

                     12035 11           Predicting human detection performance in magnetic resonance imaging (MRI) with total
                                        variation and wavelet sparsity regularizers [12035-43]

                     12035 12           Learned Hotelling observers for use with multi-modal data [12035-44]

                     12035 13           Performance of list mode Hotelling observer and comparison to a neural network observer
                                        [12035-45]

                     12035 14           Investigation of adversarial robust training for establishing interpretable CNN-based numerical
                                        observers [12035-46]

                     12035 15           Performance evaluation of image quality metrics for perceptual assessment of low-dose
                                        computed tomography images (Cum Laude Poster Award) [12035-47]

                     12035 16           Semi-blinded freehand 3D ultrasound with novice users [12035-48]

                                                                                                                                       v

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12035 17           Varying performance levels for diagnosing mammographic images depending on reader
                                        nationality have AI and educational implications [12035-49]

                     12035 18           Diagnostic efficacy in screening mammograms does not improve with peer reading strategy:
                                        a Sino-Australian study [12035-50]

                     12035 19           Influence of deep learning reconstruction on task-based model observer performance in CT:
                                        an anthropomorphic head phantom study [12035-52]

                     12035 1A           Task-specific evaluation of clinical pediatric fluoroscopy systems (Cum Laude Poster Award)
                                        [12035-53]

                     12035 1B           Visibility of noise texture changes in CT images [12035-54]

                     12035 1C           Noise2Quality: non-reference, pixel-wise assessment of low dose CT image quality [12035-55]

                     12035 1D           Camera-based distance detection and contact tracing to monitor potential spread of
                                        COVID-19 [12035-56]

                     12035 1E           High volume chest radiography to facilitate pulmonary nodule identification on chest
                                        radiographs [12035-58]

                vi

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Conference Committee

                               Symposium Chairs
                                                Metin N. Gurcan, Wake Forest Baptist Medical Center (United States)
                                                Robert M. Nishikawa, University of Pittsburgh (United States)

                               Conference Chairs
                                                Claudia R. Mello-Thoms, University Iowa Carver College of Medicine
                                                  (United States) and University of Pittsburgh (United States)
                                                Sian Taylor-Phillips, The University of Warwick (United Kingdom)

                               Conference Program Committee
                                                Craig K. Abbey, University of California, Santa Barbara (United States)
                                                Mark A. Anastasio, Washington University in St. Louis (United States)
                                                Susan M. Astley, The University of Manchester (United Kingdom)
                                                Jongduk Baek, Yonsei University (Korea, Republic of)
                                                François O. Bochud, Center Hospitalier University Vaudois
                                                    (Switzerland)
                                                Jovan G. Brankov, Illinois Institute of Technology (United States)
                                                Yan Chen, Loughborough University (United Kingdom)
                                                Brandon D. Gallas, U.S. Food and Drug Administration (United States)
                                                Howard C. Gifford, University of Houston (United States)
                                                Stephen L. Hillis, The University of Iowa (United States)
                                                Elizabeth A. Krupinski, Emory University School of Medicine
                                                (United States)
                                                Matthew A. Kupinski, College of Optical Sciences, The University
                                                of Arizona (United States)
                                                Mark F. McEntee, University College Cork (Ireland)
                                                Robert M. Nishikawa, University of Pittsburgh (United States)
                                                Ljiljana Platiša, Universität Gent (Belgium)
                                                Ingrid S. Reiser, The University of Chicago (United States)
                                                Frank W. Samuelson, U.S. Food and Drug Administration
                                                (United States)
                                                Pontus A. Timberg, Scanias Universität Hospital (Sweden)

                                                                                                                          vii

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Proc. of SPIE Vol. 12035 1203501-8
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