RAP RIKEN Center for Advanced Photonics 2021 2022
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RAP
RIKEN Center for Advanced Photonics
2021 - 2022
RIKEN Center for Advanced Photonics
2-1, Hirosawa, Wako, Saitama, 351-0198, Japan
https://rap.riken.jp/en/
RIKEN 2021-016
Opening up new horizons with photonics
RIKEN Center
RIKEN Center for Advanced Photonics (RAP) is helping ever seen before. Being able to see objects helps us to for Advanced Photonics
to realize the dream of making the invisible visible. understand and manipulate them.
As one example, stroboscopes, which allow us to see The work of the Center for Advanced Photonics Extreme Photonics Research Group
high-speed phenomena by pulsing light in a short focuses not simply on making discoveries that will be Attosecond Science Research Team .......................................... 04
duration, cannot catch the movements of molecules or recognized by the research community, but rather on Team Leader Katsumi
Midorikawa
atoms because they simply move too fast. However, contributing to society by developing practical
Ultrafast Spectroscopy Research Team ..................................... 05
thanks to research in photonics, lasers developed to applications of advanced photonics. Team Leader Tahei Tahara
generate pulses at even shorter duration such as 10-15
Just as our social infrastructure was transformed by Space-Time Engineering Research Team ................................... 06
second (1 femtosecond) or 10-18 second (1 attosecond)
the steam engine in the 19th century and by electronics Team Leader Hidetoshi
Katori
now allow us to see the movements of electrons in
in the 20th century, photonics technology will lead to
atoms or molecules. Quantum Optoelectronics Research Team ................................. 07
another transformation of social infrastructure in the Team Leader Yuichiro
Kato
Electron microscopy makes it possible for us to current century.
observe objects at extremely high resolution. However
it requires the specimen to be put in a vacuum, making
The possibilities opened by photonics are expanding. Subwavelength Photonics Research Group
We are still in the very early stage of this new
it impossible to see living cells. Using an optical Live Cell Super-Resolution Imaging Research Team ................. 08
revolution.
microscope opens up that possibility. It was generally Team Leader Akihiko
Nakano
thought that it was impossible to picture objects RIKEN Center for Advanced Photonics is committed to
Biotechnological Optics Research Team .................................... 09
smaller than half of the wavelength of light in the visible expanding the horizons of photon science. Team Leader Atsushi
Miyawaki
spectrum, but the super-resolution microscopes break
Image Processing Research Team ............................................. 10
this barrier and allow us to access the nanoworld.
Team Leader Hideo
Yokota
We sometimes need to inspect the inner structure of a Innovative Photon Manipulation Research Team ....................... 11
device or look for contamination in foods without Team Leader Takuo Tanaka
destroying a sample. Terahertz wave makes this
Advanced Laser Processing Research Team ............................. 12
possible. Terahertz wave, which has been called the
Team Leader Koji
Sugioka
“unexplored spectrum of light,” is now moving into the
application phase thanks to advances in light sources
and detectors. Terahertz-wave Research Group
In addition, applications in the field of photonics are Tera-Photonics Research Team ................................................. 13
Team Leader Hiroaki
Minamide
expanding in areas such as light wave manipulation Center Director
with metamaterials, relativistic geodesy using Katsumi Midorikawa Terahertz Sensing and Imaging Research Team ....................... 14
ultraprecision optical lattice clocks, nondestructive Team Leader Chiko
Otani
inspection of concrete structures with a compact Terahertz Quantum Device Research Team ............................... 15
neutron source, all making visible what nobody has Team Leader Hideki
Hirayama
Advanced Photonics Technology Development Group
Photonics Control Technology Team .......................................... 16
Team Leader Satoshi
Wada
Ultrahigh Precision Optics Technology Team ............................ 17
Team Leader YutakaYamagata
Neutron Beam Technology Team ................................................ 18
Team Leader Yoshie
Otake
Advanced Manufacturing Support Team .................................... 19
Team Leader Yutaka
Yamagata
Office of the Center Director Director Akihiko Nakano
Extreme Photonics Research Group Extreme Photonics Research Group
Attosecond Science Research Team Ultrafast Spectroscopy Research Team
Team Leader Katsumi Midorikawa Dr.Eng. Team Leader Tahei Tahara D.Sci.
Fields Fields
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Interdisciplinary Science and Engineering, Expanding the horizon of optical science Elucidating complex molecular dynamics Chemistry, Physics, Biology / Biochemistry
Engineering, Physics, Chemistry
by attosecond photonics with femtosecond light Keywords
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Keywords
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Ultrafast spectroscopy, Nonlinear spectroscopy,
Attosecond Science, Ultrafast Lasers, Strong Field Nonlinear optical process in the XUV region is of paramount importance not only in the Most of the phenomena in nature are realized by the dynamic behavior of molecules. Single molecule spectroscopy,
Physics, Nonlinear Optics, Multiphoton Microscopy Dynamics, Interface
field of quantum electronic but also in ultrafast optics. From the viewpoint of quantum Among them, chemical reactions are critically important, which dynamically cause the
Publications Publications
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electronics, new features of the interaction between intense XUV photons and matters cleavage and formation of chemical bonds and alter the nuclei arrangement within the
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1. Kanda, N., Imahoko, T., Yoshida, K., Tanabashi, A., are expected to be revealed through observation of those nonlinear phenomena. On the molecules. Even non-reactive molecules are vibrating, which provides rich information 1. Kusaka, R., Nihonyanagi, S., and Tahara, T.: “The
Eilanlou, A. A., Nabekawa, Y., Sumiyoshi, T., photochemical reaction of phenol becomes
Kuwata-Gonokami, M., and Midorikawa, K.: other hand, those nonlinear processes in the XUV region is indispensable for progress about the molecular properties. Because the timescale of such molecular motion is ultrafast at the air–water interface” , Nat. Chem.
"Opening a new route to multiport coherent XUV 13, 306 (2021).
sources via intracavity high-order harmonic of attosecond science including attosecond atomic/molecular physics and chemistry, femtosecond (quadrillionth), femtosecond spectroscopy is essential for elucidating 2. Inoue, K., Ahmed, M., Nihonyanagi, S. and Tahara,
generation” , Light: Sci & Appl. 9, 168 (2020). T.: “Reorientation-induced relaxation of free OH at
2. Lin, Y-C., Nabekawa, Y., and Midorikawa, K.: because it is very useful for investigating ultrafast phenomena directly in attosecond chemical phenomena. Our team investigates the dynamics of molecules from the air/water interface revealed by ultrafast
“Optical parametric amplification of sub-cycle heterodyne-detected nonlinear spectroscopy” ,
shortwave infrared pulses” , Nat. Commun. 11, time scale. Using high harmonic generation by intense femtosecond laser technology, fundamental to complex systems, as well as the molecules in special environments Nat. Commun. 11, 5344 (2020).
3413 (2020). 3. Ahmed, M., Inoue, K., Nihonyanagi, S., and Tahara,
we are pursuing extreme optical science including XUV nonlinear optics and attosecond such as interfaces. We extend the frontier of molecular science through the
3. Fu, Y., Nishimura, K., Shao, R., Susa, A., T.: “Hidden isolated OH at the charged
Midorikawa, K., Lan, P., and Takahashi, E. J.: “High physics/chemistry. development and use of advanced spectroscopic methods. hydrophobic interface revealed by
efficiency ultrafast water-window harmonic two-dimensional heterodyne-detected VSFG
generation for single-shot soft x-ray spectroscopy” , Angew. Chem. Int. Ed. 59, 9498
spectroscopy” , Commun. Phys. 3, 92 (2020). (2020).
4. Xue, B., Tamaru, Y., Yuan, H., Lan, P., Mücke, O. D., 4. Kuramochi, H., Takeuchi, S., Iwamura, M., Nozaki,
Suda, A., Midorikawa, K., and Takahashi, E. J.: K., and Tahara, T.: “Tracking photoinduced Au–Au
“Fully stabilized multi-TW optical waveform bond formation through transient terahertz
synthesizer: Toward gigawatt isolated attosecond vibrations observed by femtosecond time-domain
pulses” , Science Advances 6, eaay2820 (2020). Raman spectroscopy” , J. Am. Chem. Soc. 141,
5. Nagata, Y., Harada, T., Watanabe, T., Kinoshita, H., 19296 (2019).
and Midorikawa, K.: “At wavelength coherent 5. Tahara, S., Kuramochi, H., Takeuchi, S., and
scatterometry microscope using high-order Tahara, T.: “Protein dynamics preceding
harmonics for EUV mask inspection” , Int. J. photoisomerization of the retinal chromophore in
Extrem. Manuf. 1, 032001 (2019). bacteriorhodopsin revealed by deep-UV
femtosecond stimulated Raman spectroscopy” ,
J. Phys. Chem. Lett. 10, 5422 (2019).
Member
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Yasuo Nabekawa / Eiji Takahashi / Member
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Yutaka Nagata / Keisuke Isobe /
Kunihiko Ishii / Satoshi Nihonyanagi /
Tomoya Okino / Takashige Fujiwara /
Korenobu Matsuzaki / Ahmed Mohammed
Yu-Chieh Lin / Kaoru Yamazaki /
Takayuki Michikawa / Tohru Kobayashi /
Bing Xue / Lu Xu / Giang Nahan Tran /
Akihiro Tanabashi / Tomohiro Ishikawa /
High-energy three-color optical waveform synthesizer
Kotaro Nshimura / Takiko Wakabayashi
for generating GW isolated attosecond pulses
Coherent nuclear motion of the chromophor of a protein in reaction
04 05
Extreme Photonics Research Group Extreme Photonics Research Group
Space-Time Engineering Research Team Quantum Optoelectronics Research Team
Team Leader Hidetoshi Katori D.Eng. Team Leader Yuichiro Kato Ph.D.
Fields Fields
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Interdisciplinary Science and Engineering, Relativistic Space-Time Engineering Towards optoelectronic devices that utilize Interdisciplinary Science and Engineering,
Engineering Engineering, Mathematical and physical sciences,
with Ultra Precise Atomic Clocks the quantum nature of electrons and photons Chemistry
Keywords
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Keywords
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Quantum electronics, Atomic clock, Quantum Clocks have served as a tool to share time, based on universal periodic phenomena; Advances in device fabrication techniques have enabled integration of individual
metrology, Optical lattice clock, Relativistic geodesy Optoelectronics, Quantum devices, Nanoscale
humankind relied upon the rotation of the earth from antiquity. The radiation from an nanomaterials, where single electrons and single photons could be addressed. We devices, Carbon nanotubes, Photonic crystals
Publications atom provides us with far more accurate periodicity. The state-of-the-art atomic clocks exploit state-of-the-art nanofabrication technologies to develop and engineer
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Publications
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1. Takamoto, M., Ushijima, I., Ohmae, N., Yahagi, T.,
sense the relativistic space-time curved by gravity, which reveal the difficulty of sharing optoelectronic devices with novel functionalities that can only be achieved by utilizing
Kokado, K., Shinkai, H., and Katori, H.: "Test of general 1. Ishii, A., Machiya, H., Kato, Y. K.: “High efficiency
relativity by a pair of transportable optical lattice dark-to-bright exciton conversion in carbon
time with others. Moreover, such clocks may be used to investigate the constancy of the quantum nature of electrons and photons at the nanoscale. We investigate devices
clocks", Nat. Photonics 14, 411-415 (2020). nanotubes” , Phys. Rev. X 9, 041048 (2019).
2. Ushijima, I., Takamoto, M., and Katori, H.: “Operational fundamental constants, where the foundation of the atomic clocks is anchored. that would allow for control over the interactions between electrons and photons at the 2. Ishii, A., Uda, T., Kato, Y. K.: “Room-temperature
magic intensity for Sr optical lattice clocks” , Phys. single-photon emission from micrometer-long
Rev. Lett. 121, 263202 (2018). Optical lattice clocks raised the possibility of ultra-stable and accurate timekeeping by quantum mechanical level, which would lead to quantum photon sources and air-suspended carbon nanotubes” , Phys. Rev.
3. Takano, T., Takamoto, M., Ushijima, I., Ohmae, N., Applied 8, 054039 (2017).
Akatsuka, T., Yamaguchi, A., Kuroishi, Y., Munekane, H., applying the "magic wavelength" protocol on optical lattices. Since the proposal of the optical-to-electrical quantum interfaces. 3. Uda, T., Yoshida, M., Ishii, A., Kato, Y. K.:
Miyahara, B., and Katori, H.: “Geopotential “Electric-field induced activation of dark excitonic
measurements with synchronously linked optical scheme in 2001, the optical lattice clocks are being developed by more than 20 groups in states in carbon nanotubes” , Nano Lett. 16, 2278
lattice clocks” , Nat. Photonics 10, 662-666 (2016). (2016).
the world, and the clocks are surpassing the uncertainty of the current SI second, becoming
4. Yamanaka, K., Ohmae, N., Ushijima, I., Takamoto, M., 4. Jiang, M., Kumamoto, Y., Ishii, A., Yoshida, M.,
and Katori, H.: “Frequency ratio of 199Hg and 87Sr one of the most promising candidates for the future redefinition of the second. Shimada, T., Kato, Y. K.: “Gate-controlled
optical lattice clocks beyond the SI limit” , Phys. Rev. generation of optical pulse trains using individual
Lett. 114, 230801 (2015). Our team develops highly precise and transportable optical lattice clocks capable of carbon nanotubes” , Nature Commun. 6, 6335
5. Ushijima, I., Takamoto, M., Das, M., Ohkubo, T., and (2015).
Katori, H.: “Cryogenic optical lattice clocks” , Nat. long time operation by introducing advanced techniques in the field of atomic physics 5. Miura, R., Imamura, S., Ohta, R., Ishii, A., Liu, X.,
Photonics 9, 185-189 (2015). Shimada, T., Iwamoto, S., Arakawa, Y., Kato, Y. K.:
and quantum optics; we thus explore applications of "space-time engineering" that fully “Ultralow mode-volume photonic crystal
nanobeam cavities for high-efficiency coupling to
Member utilize the novel time resource provided by such clocks. For example, a transportable
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individual carbon nanotube emitters” , Nature
Commun. 5, 5580 (2014).
Masao Takamoto / Atsushi Yamaguchi ultraprecise atomic clock, which may be taken out into the field, will function as a
gravitational potential meter. We experimentally investigate the impact of such Member
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relativistic geodesy and new roles for clocks in the future. Daichi Kozawa / Shun Fujii / Zhen Li /
Daiki Yamashita
Scanning electron micrograph of a suspended carbon nanotube field effect transistor
Remote frequency comparison of optical lattice clocks between RIKEN and the University
of Tokyo (UTokyo) reveals their different tick rates as predicted by general relativity.
06 07
Subwavelength Photonics Research Group Subwavelength Photonics Research Group
Live Cell Super-Resolution Imaging Research Team Biotechnological Optics Research Team
Team Leader Akihiko Nakano D.Sci. Team Leader Atsushi Miyawaki M.D., Ph.D
Fields Fields
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Biological Sciences, Complex systems, Observe nano-scale activities within a living cell Bioimaging Technologies Medicine, dentistry, and pharmacy,
Interdisciplinary science and engineering, Engineering, Biological Sciences,
Biology / Biochemistry by sub-wavelength high-speed imaging by use of glowing proteins Biology / Biochemistry
Keywords Keywords
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Light is a cutting-edge tool for life science research. Development of useful fluorescent We label a fluorescent probe on a specific region of a biological molecule and bring it
Membrane traffic, Vesicular transport, Bio-imaging, Fluorescence protein,
Super-resolution live imaging, probes and the advancement of light microscope technologies have brought us a new back into a cell. We can then visualize how the biological molecule behaves in response Chromophore group
Confocal microscopy, Organelles
world of “live” imaging within a cell. We are developing super-resolution confocal live to external stimulation. Since fluorescence is a physical phenomenon, we can extract
Publications
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Publications imaging microscopy (SCLIM) by the combination of a high-speed confocal scanner and a various kinds of information by making full use of its characteristics. For example, the
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1. Katayama, H., Hama, H., Nagasawa, K., Kurokawa, H.,
1. Shimizu, Y., Takagi, J., Ito, E., Ito, Y., Ebine, K., Sugiyama, M., Ando, R., Funata, M., Yoshida, N.,
high-sensitivity camera system. With this method we will observe membrane trafficking excited energy of a fluorescent molecule donor transfers to an acceptor relative to the Homma, M., Nishimura, T., Takahashi, M., Ishida, Y.,
Komatsu, Y., Goto, Y., Sato M., Toyooka, K., Ueda,
T., Kurokawa, K., Uemura, T., and Nakano, A.: Hioki, H., Tsujihata, Y., Miyawak,i A.: “Visualizing and
and organellar dynamics in living cells at high-speed and sub-wavelength space resolution distance and orientation between the two fluorophores. This phenomenon can be used Modulating Mitophagy for Therapeutic Studies of
“Cargo sorting zones in the trans-Golgi network
visualized by super-resolution confocal live Neurodegeneration” , Cell 181(5), 1176-1187 (2020).
(4D) and elucidate underlining molecular mechanisms. We will also try to extend this to identify interaction between biological molecules or structural change in biological
imaging microscopy in plants” , Nat. Commun. 2. Yoshioka-Kobayashi, K., Matsumiya, M., Niino, Y.,
12:1901 (2021). technology to medical and pharmacological applications. molecules. Besides, we can apply all other characteristics of fluorescence, such as Isomura, A., Kori, H., Miyawaki, A., Kageyama, R.:
2. Rizzo, R., Russo, D., Kurokawa, K., Nakano, A., “Coupling delay controls synchronized oscillation in
Corda, D., D’ Angelo, G., Luini, A. et al.: “Golgi polarization, quenching, photobleaching, photoconversion, and photochromism, in the segmentation clock” , Nature 580(7801), 119-123
maturation-dependent glycoenzyme recycling (2020).
controls glycosphingolipid biosynthesis and cell experimentation. Cruising inside cells in a super-micro corps, gliding down in a 3. Iwano, S., Sugiyama, M., Hama, H., Watakabe, A.,
growth via GOLPH3” , EMBO J. 40:e107238 Hasegawa, N., Kuchimaru, T., Tanaka, KZ., Takahashi,
(2021). microtubule like a roller coaster, pushing our ways through a jungle of chromatin while M., Ishida, Y., Hata, J., Shimozono, S., Namiki, K.,
3. Rodriguez-Gallardo, S., Kurokawa, K., Fukano, T., Kiyama, M., Okano, H., Kizaka-Kondoh, S.,
Sabido-Bozo, S., Cortes-Gomez, A., Ikeda, A.,
hoisting a flag of nuclear localization signal --- we are reminded to retain a playful and McHugh, TJ., Yamamori, T., Hioki, H., Maki, S.,
Zoni, V., Aguilera-Romero, A., Perez-Linero, A.M., Miyawaki, A.: “Single-cell bioluminescence imaging of
Lopez, S., Waga, M., Araki, M., Nakano, M.,
adventurous perspective at all times. What matters is mobilizing all capabilities of deep tissue in freely moving animals” , Science, 359
Riezman, H., Funato, K., Vanni, S., Nakano, A., (6378): 935-939. (2018).
and Muñiz, M.: “Ceramide chain
science and giving full play to our imagination. 4. Sakaue-Sawano, A., Yo, M., Komatsu, N., Hiratsuka, T.,
length-dependent protein sorting into selective Kogure, T., Hoshida, T., Goshima, N., Matsuda, M.,
endoplasmic reticulum exit sites” , Sci. Adv. Miyawaki, A.: “Genetically encoded tools for optical
6:eaba8237 (2020). dissection of the mammalian cell cycle” , Mol. Cell, 68:
4. Tojima, T., Suda, Y., Ishii, M., Kurokawa, K., and 626-640. (2017).
Nakano, A.: “Spatiotemporal dissection of the 5. Hama, H., Hioki, H., Namiki, K., Hoshida, T., Kurokawa,
trans-Golgi network in budding yeast” , J. Cell H., Ishidate, F., Kaneko, T., Akagi, T., Saito, T., Saido, T.,
Sci. 132:jcs231159 (2019). Miyawaki A.: “ScaleS: an optical clearing palette for
5. Kurokawa, K., Osakada, H., Kojidani, T., Suda, Y., biological imaging” , Nat. Neurosci., 18 (10):
(Left) SCLIM2 microscope. 1518-1529. (2015).
Asakawa, H., Haraguchi, T., and Nakano, A.:
“Visualization of secretory cargo transport (Right) Yeast trans-Golgi network (red) and clathrin-coated vesicles (green) assembling and
within the Golgi apparatus in living yeast cells” , leaving there. Captured from a high-speed 3D movie taken by SCLIM2. Member
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J. Cell Biol. 218:1602-1618 (2019).
Masahiko Hirano / Asako Tosaki
Member
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Kazuo Kurokawa / Takuro Tojima / Natsuko Jin /
Wataru Yamamoto / Daisuke Miyashiro /
Tomohiro Uemura / Yasuyuki Suda / Yoko Ito /
Emi Ito / Kumiko Ishii / Miho Waga / Cultured HeLa cells expressing the photoconvertible fluorescent protein, Keade.
Yutaro Shimizu Before (left) and after (right) multiple, local irradiation of violet laser light,
green-to-red color conversion occurred in the cytosol or nucleus of targeted cells.
08 09
Subwavelength Photonics Research Group Subwavelength Photonics Research Group
Image Processing Research Team Innovative Photon Manipulation Research Team
Team Leader Hideo Yokota D.Eng. Team Leader Takuo Tanaka D.Eng.
Fields Fields
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Engineering, Informatics, Computer Science Image processing research Lightwave manipulation Engineering, Complex systems,
Interdisciplinary science and engineering
Keywords for scientific information by subwavelength structures
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Keywords
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Multi dimensional image processing,
Multi dimensional imaging, Bioengineering, Our goal is to develop original RIKEN data processing technology and multidimensional Our team intensively studies novel photon manipulation technologies using knowledge Metamaterials, Plasmonics, Nanophotonics,
Image analysis, Medical engineering Near-field Optics, Applied Optics
measurement technology in order to contribute to understanding biological phenomena. and experiences obtained from the researches on light wave interaction with
Publications
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Publications
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We are especially contributing to the fields of mathematical biology, bio-medical sub-wavelength fine structures. These photon manipulation technologies will be applied
1. An, G., Akiba, M., Omodaka, K., Nakazawa, T.,
Yokota, H.: "Hierarchical deep learning models simulations as well as medical diagnostic and treatment technology by researching and for three-dimensional nanofabrication systems, ultra-high sensitive molecular sensing 1. Olaya, C. M., Hayazawa, N., Hermosa, N., and
using transfer learning for disease detection and Tanaka, T.: "Angular Goos-H nchen shift sensor
classification based on small number of medical developing new data and image processing technologies and establishing new tools for devices, and so on. Figure (a) shows a scanning electron microscope image of RIKEN’ s using gold film enhanced by surface plasmon
images", Scientific Reports resonance", J. Phys. Chem. A 125, 451-458 (2021).
10,1038/s41598-021-83503-7 (2021). quantification of biological phenomena, intended for researchers both inside and outside logo consists of a sub-wavelength aluminum structure, which absorbs light of certain 2. Balois, M. V., Hayazawa, N., Yasuda, S., Ikeda, K.,
2. Inoue ,J., Okada, M., Nagao, H., Yokota, H., Adachi, Y.: Yang, B., Kazuma, E., Yakota, Y., Kim, Y., and
“Development of Data-Driven System in Materials RIKEN. wavelength determined by its size and shape. Figure (b) shows an observed image of Tanaka, T.: “Visualization of subnanometric local
Integration” , Materials Transactions 61(11), 2058-2066, phonon modes in a plasmonic nanocavity via
DOI: 10.2320/matertrans.MT-MA2020006 (2020). the RIKEN’ s logo under white light illumination. Figure (c) shows a demonstrated color tip-enhanced Raman spectroscopy in ambient” ,
NPJ 2D Mater. Appl. 3, 38 (2019).
3. Sato, D., Takamatsu, T., Umezawa, M., Kitagawa, Y.,
Maeda, K., Hosokawa, N., Okubo, K., Kamimura, M.,
palette covering a broad gamut of colors. 3. Su, D.-S., Tsai, D. P., Yen, T.-J., and Tanaka, T.:
Kadota, T., Akimoto, T., Kinoshita, T., Yano, T., “Ultrasensitive and Selective Gas Sensor Based on
Kuwata, T., Ikematsu, H., Takemura, H., Yokota, H., a Channel Plasmonic Structure with an Enormous
Soga, K.: “Distinction of surgically resected Hot-spot Region” , ACS Sensors 4, 2900-2907
gastrointestinal stromal tumor by near-infrared (2019).
hyperspectral imaging” , Scientific Reports 10(1), 4. Le, H.-H.-T., Morita, A., Mawatari, K., Kitamori, T.,
DOI: 10.1038/s41598-020-79021-7 (2020). and Tanaka, T.: "Metamaterials-Enhanced Infrared
4. Yamashita, N., Morita, M., Yokota, H., Mimori-Kiyosue, Y.: Spectroscopic Study of Nanoconfined Molecules
"Digital Spindle: A New Way to Explore Mitotic Functions by Plasmonics-Nanofluidics Hydrid Device", ACS
by Whole Cell Data Collection and a Computational Photonics 5, 3179-3188 (2018).
Approach", Cells Vol. 9(5), 1255 (2020). 5. Mudachathi, R. and Tanaka, T.: “Up Scalable Full
5. Sera, T., Higa, S., Zeshu, Y., Takahi K., Miyamoto, S., Colour Plasmonic Pixels with Controllable Hue,
Fujiwara, T., Yokota, H., Sasaki, S., Kudo, S.: “A Brightness and Saturation” , Sci. Rep. 7, 1199
metabolic reaction–diffusion model for PKCα (2017).
translocation via PIP2 hydrolysis in an endothelial
cell” , Biochem J.477 (20): 4071–4084 (2020).
Member
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Member
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Norihiko Hayazawa / Maria Vanessa Balois /
Shin Yoshizawa / Satoshi Oota / Shigeho Noda / Bikas Ranjan / Shun Hashiyada /
Takashi Michikawa / Satoko Takemoto / Cheng-Hung Chu /
Image Processing Cloud
Masahiko Morita / Norio Yamashita / Zhe Sun / Maria Herminia Marallag Balgos /
Sakiko Nakamura / Yuki Tsujimura / Takashi Yamaguchi / Nobuyuki Takeyasu /
Masaomi Nishimura / Xianping Zhang / Taka-aki Yano / Yuto Moritake
Hiroaki Iwase / Takashi Uematsu
Colors created by metamaterial absorber that consists of subwavelength aluminum structure.
10 11
Subwavelength Photonics Research Group Terahertz-wave Research Group
Advanced Laser Processing Research Team Tera-Photonics Research Team
Team Leader Koji Sugioka D.Eng. Team Leader Hiroaki Minamide D.Eng.
Fields
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Fields
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Engineering, Materials Sciences, Femtosecond Laser 3D Micro/Nanofabrication: Leading Terahertz science & applications Engineering,
Interdisciplinary science and engineering
Interdisciplinary science and engineering,
Multidisciplinary Creation of 3D Structures Made of Pure Protein with innovative Tera-photonics technology
Keywords
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Keywords
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Our research team is developing advanced laser processing techniques which realize Our team develops state-of-the-art frequency-tunable THz-wave sources which exploit Development of kilo-watt-power Terahertz-wave
Femtosecond laser, Laser processing, source, Sensitive Terahertz-wave detection,
Micro/nanofabrication, 3D fabrication, Biochip low environmental load, high quality, high efficiency fabrication of materials. In new THz-wave application fields. A nonlinear optical process is utilized for realizing the Terahertz-wave applications,
Nondestructive measurements, Nonlinear optics
particular, by using femtosecond lasers, novel material processing techniques including THz-wave source which lights up the THz-wave gray zone, and our original design and
Publications
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Publications
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3D fabrication, surface nanostructuring, novel nanomaterial synthesis, and tailored method will be demonstrated. We develop THz sources with high output, wide tunability,
1. Notake, T., Iyoda, T., Arikawa, T., Tanaka, K., Otani,
1. Sima, F., Kawano, H., Hirano, M., Miyawaki, A., C., and Minamide, H.: "Dynamical visualization of
Obata, K., Serien, D., and Sugioka, K.: “Mimicking beam processing are developed, which are applied for fabrication of functional high stability and narrow linewidth.
anisotropic electromagnetic re-emissions from a
intravasation–extravasation with a 3D glass single metal micro-helix at THz frequencies",
nanofluidic model for the chemotaxis-free micro/nanodevices. As one of examples of the 3D fabrication, our team successfully Active collaboration with both internal and external research groups is carried out for
Scientific Reports 11, Article number: 3310, pp. 1-7
migration of cancer cells in confined spaces” , (2021).
Adv. Mater. Technol. 5, 2000484 (2020). created a 3D complex shape of pure protein such as bovine serum albumin (BSA). exploring new applications by development of instrument combined with new THz-wave
2. Takida,* Y., Nawata,* K., and Minamide, H.:
2. Serien, D., and Sugioka, K.: “Three-dimensional sources. Advanced THz-wave technologies are also being developed in cooperation “Security screening system based on
printing of pure proteinaceous microstructures by
Furthermore, enhanced green fluorescent protein and enhanced blue fluorescent protein
terahertz-wave spectroscopic gas detection” , Opt.
femtosecond laser multi-photon crosslinking” , with industry to establish practical THz-wave sources and technologies in the world. Express Vol. 29 Issue 2, pp. 2529-2537 (2021).
ACS Biomater. Sci. Eng. 6, 1279-1287 (2020).
were formed on a single substrate to realize a two-color fluorescence image exhibiting a
(*equal contribution)
3. Bai, S., Serien, D., Hu, A., and Sugioka, K.: RIKEN logo. The 3D proteinaceous micro and nanostructures fabricated by this 3. Han, Z., Ohno, S., and Minamide, H.: “Spectral
“Three-dimensional microfluidic SERS chips phase singularity in a transmission-type
fabricated by all-femtosecond-laser- processing technique will offer many applications including cell culture, tissue engineering, double-layer metamaterial” , Optica Vol. 7 No. 12,
for real-time sensing of toxic substances” , Adv. pp.1721-1728 (2020).
Funct. Mater. 28, 1706262 (2018). biochips, micromachines, etc. 4. Takida, Y., Suzuki, S., Asada, M., and Minamide, H.:
4. Wu, D., Xu, J., Niu, L., Wu, S., Midorikawa, K., and “Sensitive terahertz-wave detector responses
Sugioka, K.: “In-channel integration of designable originated by negative differential conductance of
microoptical devices using flat resonant-tunneling-diode oscillator” , Appl. Phys.
scaffold-supported femtosecond-laser Lett. Vol. 117 Issue 2, 021107 (2020).
microfabrication for coupling-free optofluidic cell
5. Takida, Y., Nawata, K., and Minamide, H.:
counting” , Light Sci. Appl. 4, e228 (2014).
“Injection-seeded backward terahertz-wave
5. Sugioka, K., and Cheng, Y.: “Femtosecond laser parametric oscillator” , APL Photonics Vol. 5 Issue
three-dimensional micro- and nanofabrication” , 6, 061301 (2020).
Appl. Phys. Rev. 1, 041303 (2014).
Member
▲
Member
▲
Takashi Notake / Kouji Nawata /
Kotaro Obata / Francesc Caballero Lucas /
Yuma Takida / Seigo Ohno /
Shi Bai / Kazunari Ozasa / Felix Sima
Yoshikiyo Moriguchi
Backward terahertz parametric oscillator（left）and organic nonlinear crystals（right）
(Left) Complex 3D microstructure of Bovine serum albumin (BSA）fabricated by femtosecond laser
3D printing
(Right) RIKEN logo fabricated by femtosecond laser 3D printing of EBFP and EGFP.
12 13
Terahertz-wave Research Group
Terahertz-wave Research Group
Terahertz Sensing and Imaging Research Team Terahertz Quantum Device Research Team
Team Leader Chiko Otani D.Sci
Team Leader Hideki Hirayama D.Eng.
Fields
▲
Fields
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Interdisciplinary science and engineering, Terahertz Sensing, Development of Optical Devise Engineering, Quantum Electronics,
Engineering, Space Science, Semiconductor Physics
Molecular Biology / Genetics, Chemistry Imaging and Applications compact and potable terahertz laser source
Keywords
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Keywords
▲
Terahertz (THz) wave has the unique characteristics such as the transparency to many
Terahertz science, Terahertz spectroscopy,
Terahertz light having both the transparency of radio wave and the high resolution of light Terahertz, Quantum cascade lasers,
Inter-subband transition,
Terahertz imaging, Terahertz control, soft materials and their spectral absorption features. These characteristics can be utilized
Superconducting detector
is expected to be used in a wide range of application fields as a light source for various Nitride semiconductors lasers,
Molecular-beam epitaxy
for many applications in various scientific and industrial fields. In this team, we are
perspective and nondestructive inspections. We are developing THz-QCL (terahertz
Publications
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developing novel technology, science and applications in THz sensing and imaging. Publications
▲
quantum-cascade laser), which is expected to be a very compact, portable, high power
1. Momiyama, H., Sasaki, Y., Yoshimine, I., Nagano,
S., Yuasa, T., Otani, C.: “Depth super-resolved Especially, we have promoted the research of THz spectroscopy of macromolecules, the 1. Wang, L., Lin, T., Wang, K., Grange, T., Birner, S. and
terahertz light source. Through the introduction of a new quantum subband structure Hirayama, H.: “Short-period scattering-assisted
imaging of infrastructures defects using a
terahertz-wave interferometer” , NDT&E challenge to the control of molecular structures and functions by the strong THz fields, terahertz quantum cascade lasers operating at
and/or nitride semiconductors, THz-QCL aiming for implementation in society is being high temperatures” , Scientific Reports Vol. 9, No.
International, in press (2021).
and the development of high-sensitivity imaging detectors for the CMB polarization 9446 (2019).
2. Yamashita, M., Otani, C.: “Intrinsic and extrinsic effects developed by performing room temperature oscillation and enlarging the operating
on intraband optical conductivity of hot carriers in 2. Wang, L., Lin, T., Wang, K., and Hirayama, H.:
measurements as well as the collaborative research and development for its practical “Parasitic transport paths in two-well
photoexcited graphene” , Physical Review Research 3, frequency region which have been impossible so far. By developing the next generation
013150 (2021). scattering-assisted terahertz quantum cascade
applications. lasers” , Applied Physics Express Vol. 12, No. 8, pp.
3. Feng, C. H., Otani, C.: “Terahertz Spectroscopy compact terahertz imaging devices, we would like to contribute to the realization of a
082003-1-5 (2019).
Technology as an Innovative Technique for Food:
Current State-of-the-Art Research Advances” , Critical prosperous society in the near future. 3. Lin, T., Wang, L., Wang, K., Grange T. and Hirayama, H.:
Reviews in Food Science and Nutrition, published “Optimization of terahertz quantum cascade lasers by
online (2020). suppressing carrier leakage channel via high-energy
state” , Appl. Phys. Express vol. 11, No. 11, 112702 1-5
4. Yamazaki, S., Harata, M., Ueno, Y., Tsubouchi, M., (2018).
Konagaya, K., Ogawa, Y., Isoyama, G., Otani, C.,
Hoshina, H.: “Propagation of THz irradiation energy 4. Wang, K., Grange, T., Lin, T., Wang, L., Jehn, Z.,
through aqueous layers: Demolition of actin filaments Birner, S., Yun, J., Terashima, W. and Hirayama, H.:
in living cells” , Scientific Reports 10, 9008 (2020). “Broading mechanisms and self-consistent gain
calculation for GaN quantum cascade laser
5. Kutsuma, H., Sueno, Y., Hattori, M., Mima, S., Oguri, S., structures” , Appl. Phys. Lett. vol. 113, No. 6,
Otani, C., Suzuki, J., Tajima, O.: “A method to measure 061109 1-5 (2018).
superconducting transition temperature of microwave
kinetic inductance detector by changing power of 5. Wang, K., Lin, T., Wang, L., Terashima, W. and
readout microwaves” , AIP Advances 10, 095320 Hirayama, H.: “Controlling loss of waveguides for
(2020). potential GaN terahertz quantum cascade lasers
by tuning the plasma frequency of doped layers” ,
Jap. J. Appl. Phys. Vol. 57, No. 8, 081001 1-5
Member (2018).
▲
Masatsugu Yamashita / Hiromichi Hoshina /
Member
▲
Yoshiaki Sasaki / Javier Miguel Hernandez /
Mingxi Chen / Yuya Ueno/ Rosalena Irma Alip (Left) Fluorescent microscope images of biopolymer (actin filaments). TsungTse Lin / Masafumi Jo / Li Wang /
(Right) The number of actin filaments with or without THz irradiation. Ke Wang
Schematic structure and operating properties of terahertz quantum-cascade laser (THz-QCL)
14 15
Advanced Photonics Technology Development Group Advanced Photonics Technology Development Group
Photonics Control Technology Team Ultrahigh Precision Optics Technology Team
Team Leader Satoshi Wada Ph.D. Team Leader Yutaka Yamagata D.Eng.
Fields Fields
▲
▲
Engineering, Mathematical and physical sciences, Development of photonics control technology Developing advanced optical components Engineering,
Interdisciplinary science and engineering
Biology / Biochemistry, Agricultural Sciences,
Medicine, dentistry, and pharmacy for science and social issues by ultrahigh precision technology Keywords
▲
Keywords
▲
Particle control and measurement, Medical and Our team investigates new optical technologies for solving world-wide environmental Our team develops advanced ultrahigh-precision/micro fabrication technologies and their Ultrahigh Precision Machining,
agricultural measurement, Trace gas measurement, Ultrahigh Precision Metrology, Aspherical Optics,
Natural energy, Space applications and energy problems. We are mainly developing remote-sensing system of poisonous application to scientific apparatuses and devices to support advanced scientific research Production Technology, Neutron Optics
Publications gas, lidar as an atmospheric monitor for high energy cosmic ray observation, and at RIKEN. Research and development plans of our team include the following four topics: Publications
▲
▲
1. Louchev, O. A. and Wada, S.: “Short-pulsed solar-pumped laser for advanced energy source. We are also developing tunable (1) Development of ultrahigh-precision optics including design, fabrication, metrology and
laser-induced breakdown in dielectrics with 1. Yamada, N., L., Hosobata, T., Nemoto, F., Hori,
strong electron superheating:diffusion-controlled K., Hino, M., Izumi, J., Suzuki, K., Hirayama, M.,
kinetics of impact ionizationand recombination” ,
laser-based biosensors for biomedical and agricultural applications. These researches computational simulation; (2) Development of ultrahigh-precision/micro fabrication
Kanno, R., and Yamagata, Y.: “Application of
Journal of the Optical Society of America B Vol. precise neutron focusing mirrors for neutron
38 Issue 4, pp. 1416-1434 (2021). will contribute to build and to maintain social environment that humans can live safely. technologies; (3) Development of materials and devices for biology or biochemistry such
reflectometry: latest results and future
2. Yasui, H., Kabayama, S., Tachibana, T., Yumoto, M., prospects” , J. Appl. Cryst. 53 (2020).
Ogawa, T., Watanabe, Y., and Wada, S.: “Evaluation Moreover, we are investigating fundamental research topics including particle control as microfluidic immunoassay devices.
of effect of platinum nanoparticles in aqueous 2. Saiki, T., Hosobata, T., Kono, Y., Takeda, M., Ishijima,
dispersion on hydrogen bonding state using with high power Lyman α coherent source, and development of laser pumped neutron In all R&D topics, our team collaborates with laboratories inside and outside of RIKEN and A., Tamamitsu, M., Kitagawa, Y., Goda, K., Morita, S.,
attenuated total reflectance infrared Ozaki, S., Motohara, K., Yamagata, Y., Nakagawa, K.,
spectroscopy” , International State-of-the-art in source. New applied researches were performed on the basis of basic research of laser helps them to construct the most advanced experimental apparatuses, which will lead to and Sakuma, I.:"Sequentially timed all-optical
Surface and Interface Fabrication Technologies I mapping photography boosted by a branched 4f
pp.78-86 (2021). materials, and nonlinear optics. innovative scientific research results. system with a slicing mirror", Opt. Express 28,
3. Wang, K.L., Jiang, J.C., Jhu, C.H., Wada, S., Sassa, 31914-31922 (2020).
T., and Horie, M.: “High-performance organic
photorefractive materials containing 2-ethylhexyl 3. Duan, H., Morita, S., Hosobata, T., Takeda, M.,
plasticized poly (triarylamine)” , J. Mater. Chem. C and Yamagata, Y.: “Profile measurement using
Vol. 8, pp. 13357-13367 (2020). confocal chromatic probe on ultrahigh precision
4. Tsuno, K., Wada, S., Ogawa, T., Ebisuzaki, T., machine tool” , Int. J. of Automation
Fukushima, T., Hirata, D., Yamada, J., and Itaya, Y.: Technology, accepted in press (2020).
(a) (b) (c) (d)
“Impulse measurement of laser induced ablation 4. Hosobata, T., Yamada, N., L., Hino, M., Yoshinaga, H.,
in vacuum” , Optics Express Vol.28 No.18, pp.
Nemoto, F., Hori, K., et al.: “Elliptic neutron-focusing
25723-.5729 (2020).
supermirror for illuminating small samples in
5. Koike, K., Fujii, K., Kawano, T., and Wada, S.: neutron reflectometry” , Optics Express Vol. 27, Issue
“Bio-mimic energy storage system with solar light
19, pp. 26807-26820 (2019),
conversion to hydrogen by combination of
photovoltaic devices and electrochemical cells https://doi.org/10.1364/OE.27.026807
inspired by the antenna-associated photosystem 5. Notake, T., Takeda, M., Okada, S., Hosobata, T.,
II” , Plant Signaling & Behavior Vol. 15 No.3, Yamagata, Y., Minamide, H.: “Characterization of
e1723946 (2020).
all second-order nonlinear-optical coefficients
of organic N-benzyl-2-methyl-4-nitroaniline
Member
▲
crystal” , Scientific Reports 9(1) (2019), DOI:
Norihito Saito / Kiwamu Kase / 10.1038/s41598-019-50951-1
Tomoki Matsuyama / Takafumi Sassa / (a) Sodium LIDAR
Takayo Ogawa / Masaki Yumoto / Katsushi Fujii / (b) Coherent Lyman-α resonance radiation source for ultra-slow muon generation An elliptic neutron focusing mirror with metallic substrate used in J-PARC BL-16(SOFIA) Member
▲
Kentaro Miyata / Masayuki Maruyama / (c) Laser inspection of infrastructure by courtesy of Shizuoka Pref. and Topcon Corp. Koichiro Shirota / Yusuke Tajima /
Takeharu Murakami / Masato Otagiri / (d) Application of photonics control technology to plant cultivation
Yoshiyuki Takizawa / Tetsuya Aoyama /
Yotaro Saito / Takane Kobayashi / LanLan Bai /
Noboru Ebizuka / Hiroyoshi Aoki /
Akinori Taketani / Michio Sakashita /
Katsuhiko Tsuno / Yukinori Kunimoto / Takuya Hosobata / Satoru Egawa /
Kei Taneishi / Kei Morishita / Yasushi Kawata / Masahiro Takeda / Yuko Sato
Toshihiro Okashita / Yoko Ono
16 17
Advanced Photonics Technology Development Group Advanced Photonics Technology Development Group
Neutron Beam Technology Team Advanced Manufacturing Support Team
Team Leader Yoshie Otake D.Sci. Team Leader Yutaka Yamagata D.Eng.
Fields Fields
▲
▲
Physics, Engineering,
Interdisciplinary science and engineering
Research and development of compact neutron system Example of manufactured parts Engineering,
Interdisciplinary science and engineering
Keywords for practical use at anytime, anywhere for scientific apparatus and number of requests
▲
Keywords
▲
Accelerator-based compact neutron system,
Characterization of microstructure and texture RIKEN has developed accelerator-driven compact pulse neutron systems for practical It is inevitably required to devise and/or maintain variety of advanced research Production technology, Mechanical machining,
evaluation in steels, Research and development of Laser machining, CAD/CAM/CAE, 3D printer
non-destructive inspection for infrastructures, use in industrial applications and non-destructive infrastructure inspection. They are instruments and equipments to promote and support laboratories for wide ranges of
Visualization of water and air hole in concrete slabs, Publications
research fields from fundamental to practical phases. The main duty of our team is to
▲
Detection of salt damage in the concrete by called RIKEN accelerator-driven compact neutron source RANS and RANS-II. RANS has
prompt-gamma neutron activation analysis 1. Ishizuka, M., Mikami, M., Leys, J. F., Shao, Y.,
succeeded to develop non-destructive inspection methods with slow and fast neutrons. develop those instruments required by researchers, and also this duty should be
Yamada, Y., and Heidenreich., S.: “Power law
Publications relation between size-resolved vertical dust flux
▲
One is the visualization method of the corrosion and its related water movement of conducted consequently from concept design to manufacture through detailed design
1. Kobayashi, T., Ikeda, S., Otake, Y., Ikeda, Y., and and friction velocity measured in a fallow wheat
Hayashizaki, N.: “Completion of a new accelerator-driven field” , Aeolian Research, 12, pp.87-99, (2014).
painted steels and the analytical method of the quantitative estimation of the water and instrumentation. Our team also deals with improvement and maintenance of working
compact neutron source prototype RANS-II for on-site 2. Abulaiti, A., Kimura, R., Shinoda, M., Kurosaki, Y., Mikami,
use” , NUCL INSTRUM METH PHYS RES A Vol.994,
movement in the painted steels, the other is the neutron engineering diffractometer for scientific experimental equipments. For these purposes, we are constantly making efforts M., Ishizuka, M., Yamada, Y., Nishihara, E., Gantsetseg,
165091 pp1-6 (2021). B.: “An observational study of saltation and dust
2. 藤田 訓裕, 岩本 ちひろ, 高梨 宇宙, 大竹 淑恵, 野田 秀作, the texture evaluation and the austenite volume fraction estimation of iron and steel. to improve our design, manufacturing and engineering capabilities for rapid services. emission in a hotspot of Mongolia” , Aeolian Research,
井田 博之.: “散乱中性子を用いた床版内欠陥の非破壊検 2014.05.002, pp.169-176, (2014).
査システム” , Proceedings of The 11th Symposium on The others are the fast neutron imaging applications. Novel scattered neutron imaging 3. Yamazawa, K., Teshima, Y., Watanabe, Y., Ikegami,
Decks of Highway Bridge JSCE pp47-52 (2020). Y., Fujiyoshi, M., Oouchi, S., Kaneko, T.:
3. Otake, Y.: “RIKEN Accelerator-driven compact neutron method to see through the fracture in the concrete slab has been successfully “Three-Dimensional Model Fabricated by Layered
systems” , EPJ Web Conf. 8th International Meeting of Manufacturing for Visually Handicapped Persons
Union for Compact Accelerator-Driven Neutron Sources developed. The compact neutron systems are expected to be widely used on-site. to Trace Heart Shape” , Springer, LNCS 7383,
(UCANS-8) Vol. 23, 01009 pp1-5 (2020). 505-508, (2012).
4. Wakabayashi, Y., Hashiguchi, T., Yoshimura, Y., Mizuta, M., 4. Oouchi, S., Yamazawa, K., Secchi, L.: “Reproduction of
Ikeda, Y., and Otake, Y.: “Study of a collimation method as a Tactile Paintings for Visual Impairments Utilized
nondestructive diagnostic diagnostic technique by PGNAA Three-Dimensional Modeling System and the Effect of
for salt distribution in concrete structures at RANS” , EPJ Web Difference in the Painting Size on Tactile Perception” ,
Conf. 8th International Meeting of Union for Compact Springer, LNCS 6180, 527-533, (2010).
Accelerator-Driven Neutron Sources (UCANS-8) vol.231, 5. Yamazawa, K., Hashizume, D., Nakao, A., Anzai, M.,
05007 pp1-7 (2020). Narahara, H., Suzuki, H.: “Proposal for Artificial
5. Xu, P.G., Ikeda, Y., Hakoyama, T., Takamura, M., Otake, Y., Bone Formation using Powder-layered
and Suzuki, H.: “In-house texture measurement using a Manufacturing: Surface and Internal Chemical
compact neutron source” , J Appl Crystallogr Vol.53, Composition of Formed Artificial Bone” ,
pp444-454 (2020). Transactions of the Japanese Society for Medical
and Biological Engineering, Vol.47 No. 4, 359-365,
(2009).
Member
▲
Member
▲
Atsushi Taketani / Masato Takamura /
Tomohiro Kobayashi / Yasuo Wakabayashi / Kenji Yamazawa / Shigeru Ikeda /
Maki Mizuta / Takaoki Takanashi / Kunihiro Fujita / Kei Sunouchi / Takeshi Fujimoto /
Chihiro Iwamoto / Mingfei Yan / Shota Ikeda /
Masahiro Takeda / Masaharu Watanuki /
Makoto Fujino / Makoto Goto/ Yoshio Matsuzaki /
Junko Ito
Haruhiko Hashikura
Examples of manufactured components for
The future imaging of compact neutron non-destructive test system on-site
scientific apparatuses and number of requests in FY2020
18 19Memo
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