VACCINATION STRATEGIES TO HELP ENHANCE BOARDING FACILITY SAFETY - Zoetis
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VACCINATION STRATEGIES
TO HELP ENHANCE
BOARDING FACILITY SAFETY
1|
SAFETY FIRST!
By keeping your canine customers
happy and healthy, their owners
should want to bring them back
again and again!
The lost revenue and damage to
credibility from a respiratory
outbreak can be devastating
Help Keep Your Facility Safe by Including Canine Flu
and Bordetella bronchiseptica Vaccination in
Your Boarding Admission Protocols
2|
VACCINATING DOGS AGAINST BORDETELLA
BRONCHISEPTICA (Bb) AND CANINE INFLUENZA VIRUS
MAY HELP REDUCE THE CHANCE OF CO-INFECTION
Sometimes a
Primary
Caused by H3N2 and
Parainfluenza
Pathogen Canine
H3N8 influenza viruses
Canine
Adenovirus
Herpesvirus
type 2
Bb Reovirus
Canine
Adenovirus
H3N2 originated from
an avian influenza
type 1
Canine
Distemper virus and H3N8
originated from an
ETIOLOGY OF CIRD1-6
equine influenza virus
CANINE
Overcrowding
Immuno-
deficiency Pneumovirus CIV INFLUENZA
VIRUS Co-infections were
identified in 33.3% of
Mycoplasma Streptococcus
Stress Humidity
sp. zooepidemicus 4,062 CIRD samples
Respiratory Canine submitted to a
& Anatomical Respiratory
Defects Coronavirus diagnostic laboratory2
3|
CANINE FLU CAN BE HIGHLY CONTAGIOUS FOR DOGS HOUSED TOGETHER AND CAN BE DEADLY7,8 100% of dogs not previously exposed are susceptible9 Deaths typically occur in dogs with severe disease; in outbreak situations the death rate is thought to be 1–5%, or slightly higher8 The cause of a dog's cough can't be distinguished based on symptoms alone. For this reason it is recommended to test symptomatic dogs to determine the cause of their cough. 4|
CIV OUTBREAKS HAVE BEEN
OCCURRING ACROSS THE COUNTRY
H3N210 and H3N811
CIV H3N8 & H3N2 positive cases
CIV H3N2 positive cases
CIV H3N8 positive cases
No positive tests reported
DOGS THAT TRAVEL TO AREAS OF THE US WHERE
! CIV HAS BEEN REPORTED CAN BE AT RISK
5|
REQUIRE YOUR CUSTOMERS TO VACCINATE THEIR
DOGS FOR CIV H3N2 AND H3N8 AT THEIR
VETERINARIAN’S OFFICE
KEEPING CUSTOMERS SAFE CAN BE A COMPETITIVE ADVANTAGE
Vaccination with Vanguard® CIV H3N8 helped reduce clinical signs:12
– Coughing and eye discharge were the most prevalent clinical
observations across all dogs
and treatments
– Incidence of cough in vaccinated dogs was 10% vs. 65% in non-
vaccinated dogs, and incidence
of eye discharge was 25% vs. 60% in non-vaccinated dogs
– Reduction of viral shedding and protection of the lungs from permanent
damage are both critical aspects of helping protect your visiting dogs
Canine Influenza Vaccine, H3N2, Killed Virus* leverages the same
platform as Vanguard® CIV
*This product license is conditional. Efficacy and potency studies are in progress.
BORDETELLA BRONCHISEPTICA CAN BE HIGHLY CONTAGIOUS FOR DOGS CONFINED IN CLOSE CONTACT SUCH AS KENNELS13 B. bronchiseptica is a major part of CIRD as it is commonly found and some dogs carry the bacteria without displaying clinical signs The American Veterinary Medical Association lists CIRD as one of its most common disease risks14 “Stress, poor ventilation, and temperature and humidity extremes are also thought to increase the susceptibility of dogs to kennel cough”13 The many stresses associated with boarding combined with the group setting of most kennels can make it easier to spread infectious organisms, such as Bordetella bronchiseptica15 7|
PARENTERAL VACCINATIONS ARE STANDARD FOR MEMBERS OF THE FAMILY Bordetella pertussis and Bordetella bronchiseptica are closely related16 There is only one option for the Bordetella pertussis vaccine in people 8|
HELP KEEP YOUR GUESTS AND YOUR FACILITY
PROTECTED FROM BORDETELLA BRONCHISEPTICA
DOGS THAT HAVE NEVER BEEN DOGS THAT HAVE BEEN VACCINATED
EXPOSED NOR VACCINATED OR EXPOSED IN THE PAST
Intranasal prime followed by injectable With the exception of one study in 2002, all
boost vaccination gave the best large scale studies of B. bronchiseptica
protection17 vaccination have been focused on puppies
receiving their first vaccination. The 2002
study demonstrated that dogs who have
been previously vaccinated or exposed to
B. bronchiseptica developed a stronger,
faster immune response after injectable
vaccination as opposed to intranasal
vaccination.18
For this reason, after a dog or puppy
receives an initial intranasal vaccine we
recommend that all subsequent
B. bronchiseptica vaccinations be
administered via the injectable route
9|WE STUDIED DATA FROM OUR COMPANION ANIMAL
IMMUNIZATION SUPPORT GUARANTEE (ISG) TO HELP
US UNDERSTAND WHAT’S CAUSING THAT COUGH19
Majority of dogs vaccinated with Bronchicine® CAe, an injectable B. bronchiseptica
vaccine from Zoetis, were carrying a pathogen other than B. bronchiseptica
ODDS OF IDENTIFYING A SINGLE PATHOGEN INFECTION IN A
COUGHING DOG
APPROXIMATE
AGENT PERCENT ODDS
M. cynos 24% 1 in 4
CRCoV 12% 1 in 9
B. bronchiseptica 7% 1 in 14
CPiV 4% 1 in 27
CIV (H3N8) 3% 1 in 40
CAV-2 0.8% 1 in 125
CDV 0.8% 1 in 125
10 |YOU DO EVERYTHING TO MAKE
SURE YOUR CUSTOMERS ARE
HAPPY WHILE THEY ARE AT
YOUR FACILITY…
WHY NOT DO EVERYTHING
YOU CAN TO MAKE SURE
THEY STAY HEALTHY TOO?
PROACTIVELY COMMUNICATE
YOUR BOARDING ADMISSION
PROTOCOLS TO LOCAL
VETERINARY HOSPITALS
All trademarks are the property of Zoetis Inc., its affiliates and/or its licensors.
11 | ©2016 Zoetis Inc. All rights reserved. March 2016. SAB-00221REFERENCES
1. Datz C. Bordetella Infections in Dogs and Cats: Pathogenesis, Clinical Signs and Diagnosis.
Compendium on Continuing Education for the Practicing Veterinarian. 2003; 25(12):896 – 901.
2. Datz C. Bordetella Infections in Dogs and Cats: Treatment and Prevention. Compendium on Continuing
Education for the Practicing Veterinarian. 2003; 25(12):902–914.
3. Ford RB. Bordetella bronchiseptica: Beyond Kennel Cough. In: Bonagura JD & Twedt DC (Eds.) Kirks
Current Veterinary Therapy XIV. Saunders Elsevier, St. Louis. 2009:646-649.
4. Chalker VJ, Toomey C, Opperman S, Brooks HW, Ibuoye MA, Brownlie J, Rycroft AN. Respiratory
disease in kennelled dogs: Serological responses to Bordetella bronchiseptica lipopolysaccharide do
not correlate with bacterial isolation or clinical respiratory symptoms. Clinical and Diagnostic Laboratory
Immunology. 2003; 10(3):352–356.
5. Keil DJ, Fenwick B. Role of Bordetella bronchiseptica in Infectious Tracheobronchitis in Dogs. JAVMA.
1998; 212(2):200–207.
6. Ford, RB. Canine Infectious Tracheobronchitis. In: Greene, C.E. (Ed) Infectious Diseases of the Dog
and Cat. 3rd Edition. Saunders – Elsevier, St. Louis. 2006:54-61.
7. Crosby JT, DVM. Canine Influenza Disease and Vaccination: H3N8 virus highly contagious for dogs
housed together http://vetmedicine.about.com/od/doghealthfaqs/a/h3n8-Disease-And-Vaccination.htm
Accessed November 14, 2015.
8. Iowa State University, Canine Influenza Fact Sheet.
http://www.cfsph.iastate.edu/Factsheets/pdfs/canine_influenza.pdf. Accessed November 14, 2015
9. Dubovi EJ and Njaa BL. Canine influenza. Vet Clin Small Anim. 2008;38:827-835.
10. Canine influenza H3N2 updates. Animal Health Diagnostic Center at Cornell University College of
Veterinary Medicine. https://ahdc.vet.cornell.edu/docs/CIV_Monitoring_20160202.pdf . Accessed
2/3/2016.REFERENCES
11.This map was produced using H3N8 data that was made available to Zoetis (Study Report No. BLOR
40813 and updated in 2014. Data was not obtained from all national and regional veterinary
laboratories. We do not know what the actual percentage of actual cases are captured in this map and
could represent a fraction of confirmed CIV cases.
12. Data on file, Study Report No. 3161R-60-09-383, Zoetis Inc.
13. McLeod L, DVM. Kennel Cough in Dogs Signs, Diagnosis and Treatment of Kennel Cough
http://vetmedicine.about.com/od/dogdiseasesconditions/a/CW-KennelCough.htm. Accessed November
14, 2015.
14. American Veterinary Medical Association. https://www.avma.org/public/PetCare/Pages/Disease-Risks-
for-Dogs.aspx. Accessed November 14, 2015.
15. Bordetella bronchiseptica in dogs. http://www.vetstreet.com/care/bordetella-bronchiseptica-in-dogs.
Accessed November 14, 2015.
16. Parkhill J, Sebaihia M, Preston A, et al. Comparative analysis of the genome sequences of Bordetella
pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 2003;35(1):32-40.
17. Ellis J, Haines D, West K, et al. Effect of vaccination on experimental infection with Bordetella
bronchiseptica in dogs. JAVMA. 2001;218(3):367-375.
18. Ellis J, Krakowka GS, Dayton A, et al. Comparative efficacy of an injectable vaccine and an intranasal
vaccine in stimulating Bordetella bronchiseptica-reactive antibody responses in seropositive dogs.
JAVMA. 2002;220(1):43-48.
19. Data on file, Zoetis Outcomes Research. Identifying pathogen infection in a coughing dog 2008-2009,
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