BIOTRANS 2019 July 7 - 11, 2019 Groningen, The Netherlands Organized by
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BIOTRANS 2019
July 7 - 11, 2019
Groningen, The Netherlands
Organized by
Conference Program
Sunday, July 7, 2019
14:00–
Registration
16:00
16:45 Marco Fraaije
(chairs) Welcome and introduction
Gerrit Poelarends
René Paas
King's Commissioner in the province of
Groningen
16:55
Welcome address
Intermezzo
Donald Hilvert
ETH Zurich
17:30 Frances Arnold Innovation by evolution: bringing
KL 1 California Institute of Technology new chemistry to life
18:30
Welcome reception/walking dinner
The reception will be offered to you by the University of Groningen,
the Municipality of Groningen and the Province of GroningenMonday, July 8, 2019
Session 1: New enzymes New reactions
Chair: Frank Hollmann (Technical University Delft)
09:00 Wolfgang Kroutil Extending the reaction toolbox for C-C, C- O and C-N bond
KL 2 University of Graz formation
09:45 Todd Hyster Radical biocatalysis – using light to reveal new enzyme
IL 1 Princeton University functions
10:15 Coffee break
Chair: Woody Fessner (TU Darmstadt)
10:45 Tristan de Rond Discovery of oxazolone biosynthetic enzymes through
L1 University of California genome mining
11:05 Xiaoguang Lei Discovery of the first intermolecular [4+2] cyclase in natural
L2 Peking University product biosynthesis
Hannah Brass
11:25 Ligases in natural product synthesis. A bridge between
Heinrich Heine University
L3 chemistry and biology
Düsseldorf
Benoit Desguin
11:45 Biosynthesis and function of the nickel-pincer cofactor of
Université Catholique de
L4 lactate racemase
Leuven
12:05 Poster Pitch Presentations
12:30
Lunch break
14:00 Poster Session I (odd numbers!)
Chair: Maurice Franssen (Wageningen University & Research)
16:00 Alison Narayan
Biocatalysis and complex molecule synthesis
IL 2 University of Michigan
Catalytic promiscuity vs. stereochemical fidelity in dynamic
16:30 David Berkowitz
reductive kinetic resolution (DYRKR) - catalytic and
L5 University of Nebraska
structural biology insights
16:50 Jan Vilím First enzymatic synthesis of nitriles solely from alcohols,
L6 University of Amsterdam ammonia and air
17:10 Lu Shin Wong
Silicateins as biocatalysts in organosiloxane chemistry
L7 University of Manchester
Roser Marin-Valls 3-Methyl-2-oxobutanoate hydroxymethyl-transferase
17:30 Consejo Superior de (KPHMT) catalyzed synthesis of 2-ketopantoate and
L8 Investigaciones Cientificas homologues aldol addition
17:50 Tom Desmet Exploration, engineering and application of sucrose
IL3 Gent University transglycosidasesTuesday, July 9, 2019
Session 2: Cascade reactions
Chair: Ulf Hanefeld (Technical University Delft)
Helen Hailes
09:00
University College Biocatalytic single-step reactions and enzyme cascades
KL 3
London
09:45 Anna Fryszkowska Rivaling nature: constructing a biocatalytic manufacturing
IL 4 Merck & Co, Inc route to an unnatural nucleoside
10:15 Coffee break
Chair: Laurence Hecquet (University Clermont Auvergne)
Fully enzymatic total synthesis of angiopterlactone B
10:45 Jan Deska
exploiting non-natural biocatalysis tools in a complex cascade
L9 Aalto University
design
Chemoenzymatic total synthesis of deoxy-, epi- and
11:05 Mattia Lazzarotto
podophyllotoxin via a biocatalytic C-H activation by 2-
L 10 University of Graz
oxoglutarate dependent dioxygenase
Margit Winkler
11:25
The Austrian Center of In vivo - in - vitro in sequence: aldehyde formation by CARs
L 11
Industrial Biotechnology
James Galman Biocatalytic cascade synthesis of unnatural amino acids and
11:45
Manchester Institute of other valuable building blocks from electron-rich biomass-
L 12
Biotechnology derived substrates
12:05 Poster Pitch Presentations
12:30 Lunch break
14:00 Poster Session II (even numbers!)
Chair: Willem van Berkel (Wageningen University & Research)
Pimchai Chaiyen
16:00 Vidyasirimedhi Institute
Enzymatic cascades for biocatalysis, biodetection and biofuel
IL 5 of Science and
Technology
Ammar Al-Shameri
16:30 Technische Universität Biosynthesis of methylated N-heterocycles from diamines at
L 13 Berlin the expense of H2 and O2
16:50 Florian Seebeck S-adenosylhomocysteine as a methyl transfer catalyst in
L 14 University of Basel biocatalytic methylation reactions
17:10 Jennifer Andexer
Polyphosphate-driven cofactor regeneration
L 15 University of Freiburg
17:30 Nico Bruns Repurposing metalloenzymes to control radical
L 16 University of Strathclyde polymerizations
17:50 Jason Micklefield Discovery, characterisation and engineering synthetic
IL 6 University of Manchester pathways towards bioactive moleculesWednesday, July 10, 2019
Session 3: Metabolic engineering
Chair: Francesco Mutti (University of Amsterdam)
09:00 Claudia Schmidt-
KL 4 Dannert From biosynthesis to functional biomaterials
University of Minnesota
09:45 Huimin Zhao
Directed evolution of pathways and genomes
IL 7 University of Illinois
10:15 Coffee break
Chair: Vladimir Kren (Czech Acadamy of Sciences)
Bruno Bühler
10:45 Helmholtz Centre for Biocatalytic oxygenation driven by photosynthesis
L 17 Enviromental Research
UFZ
Markus Buchhaupt
11:05 Expanding the isoprenoid building block repertoire with an
DECHEMA Research
L 18 IPP methyltransferase from Streptomyces monomycini
Institute
11:25 Vanessa Hubracht
Ruhr-Universität Bochum An enzymatic total synthesis of terpenes
L 19
Biocatalytic synthesis of aliphatic nitriles at a substrate
11:45 Alessa Hinzmann loading of up to 1.4 kg/L: a record achieved with a heme
L 20 Bielefeld University protein
12:05 Rodrigo de Souza Continuous-flow strategies on chemo and enzymatic
IL 8 Federal University of Rio reactions towards API synthesis
de Janeiro
12:35 Lunch break
14:00 Excursions
19:00 Conference Dinner at Ni Hao (Stadspark), Paviljoenlaan 3,
GroningenThursday, July 11, 2019
Session 4: Enzyme Engineering
Chair: Gerard Roelfes (University of Groningen)
09:00 Don Hilvert
Design and evolution of artificial metalloenzymes
KL 5 ETH Zurich
09:45 Elizabeth Gillam Looking to the past to evolve enzymes for the future: thermostable
IL 9 University of Queensland cytochrome P450 enzymes for biocatalysis
10:15 Coffee break
Chair: Sergio Riva (University of Milan)
Markus Dick
10:45 Towards a general biocatalyst for noncanonical amino acids
California Institute of
L 21 synthesis: directed evolution of TrpB
Technology
11:05 Cathleen Zeymer Engineering artificial metalloenzymes based on de novo metal-
L 22 ETH Zurich protein complexes
11:25 Joyce Liu Engineering enzymes for cascade synthesis of a steviol glycoside
L 23 Codexis using CodeEvolver® protein engineering technology
11:45 Jonathan Latham Industrial application of a redox-neutral oxidation/reductive
L 24 GSK amination cascade
12:05 Marco van den Berg
Enzymatic reduction of cystine to cysteine
IL 10 DSM Delft
12:35 Lunch break
Chair: Kurt Faber (University of Graz)
14:00 Roland Ludwig
Depolymerizing cascade reactions of the fungal secretome
IL 11 University of Vienna
14:30 Bernard Hauer Completing the circle: investigations on key mechanistic steps
IL 12 University of Stuttgart unveil the full potential of squalene-hopene cyclase
15:00 Coffee break
BIOTRANS AWARDS & LECTURES
Biotrans Junior Award
Lecture Synthetic enzyme cascades – from scratch to process
15:30
Dörte Rother intensification
Research Center Jülich
Biotrans Senior Award
Lecture Engineered enzymes by computational design and screening of
16:00
Dick Janssen mutant enzyme libraries
University of Groningen
16:45 Poster Prizes & ClosingYou can also read
