Dexa Laboratories of Biomolecular Sciences - "Connect to Accelerate" - HANNOVER MESSE
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“Connect to
Accelerate”
Dexa
Laboratories of
Biomolecular
Sciences
Indonesia’s Riau-Jambi:
426 species have been
Kalimantan:
Minimum 4000 Southeast Sulawesi:
Natural used for medicines
by traditional Melayu,
species can be used
for herbal medicines
449 species have been used
by local community in many
Heritage Mamakand Anak dalam
tribes
traditional formulas
South Maluku:
216 species have been
Division of East & West as traditional medicines by
Indonesia according to local community.
the Wallace Line 1859
Tasikmalaya (West Java):
188 Species have been used
for herbal medicines
Surakarta (Central Java):
West Nusa Tengara
1734 traditional formulas
40 species have been used for
in Serat Centhini (ancient document
herbal medicines by local community
recording traditional healing methods
at Taman Rinjani national park
Biomolecular Research using Indonesian Biodiversity since 2005
A SUPERIOR
MEDICAL THERAPEUTICS
Indonesia is the second
Indonesian largest biodiversity
resources for herbal
Modern medicines.
Herbal
Medicines
How Indonesian medicinal plants made into drugs using
modern pharmacological techniques
Database Protein Chemical Identify Optimize Test safety/efficacy
/genes targets diversity ‘hit’ ‘hit’ structure
humans
animals
Translating Indonesian biodiversity into a new therapeutic herbal medicines
Bioactive fraction is a fraction
Fraction is the result that has been proven to possess
of extract separation certain pharmacological
according to its activities in line with the
Extract is proposed indications.
the result of chemical properties
simplicia done through
components fractionation
extracted methods.
using specific
solvents with BIO
Simplicia is an detailed FR ACT
unprocessed extraction AC IVE
natural methods. TIO
PURITY
substance N
Natural
used for
medicinal
ingredients. FR
AC
Product TIO
N
Development EX
TR
Based on
AC
T
Chemical SIM
PL
ICI
A
Profiling
COMPLEXITY
The higher the purity of a herbal medicinal product, the more
complex the advanced fractionation process will be.
TCEBS system combines chemistry and gene protein expression bioassay system
Target
Gene / Protein
A B C D E
DLBS
Products 1 2 3 4 5 6 7
3a 3b 3c 3d 3e 3f 3g 3h 3i
F1 F2 F3 F4 F5 F6 F7
AA BB CC DD EE
Ophthalmology
Pain Glaucoma
Neuropathic Pain Diabetic Macular Edema
Chronic Pain Age-Related Macular
Acute Pain Degeneration
Dry Eye
Central Nervous System
Alzheimer’s Disease
Cardiovascular/
Schizophrenia Metabolic Disease
Cognition Atherosclerosis
ADHD Hypertension
Anxiety Thrombosis
Depression Diabetes
Obesity
Osteoporosis
Allergy/Respiratory Muscle Wasting
Areas of Asthma
COPD
Chronic Sinusitis
Infectious Disease
Research Allergic Rhinitis
HIV
HCV
RTI
and Inflammation
Gram (-)
Pathogenesis Inhibitor
Discovery Rheumatoid Arthritis
Osteoarthritis
Inflammatory Pain
Urology/Sex Health
OAB and Stress
Incontinence
Endometriosis
Premature Ejaculation
Gastrointestinal Female Sexual
Indications Dysfunction
GERD Erectile Dysfunction
IBS Oncology Dermatology
IBD Immunotherapy/Vaccines Alopecia
Liver Disease Signal Transduction and Scarring
Anti-angiogenic agents Skin disorders
Cytotoxic Agents
Making Indonesian Evidence-based medicines
Modern Herbal Medicines which are effective and safe.
1 2 3 4 5 6
BIOACTIVE pre-clinical clinical raw Finish WORLD
FRACTION test trial material product WIDE
production PATIENTS
BAF
AAALAC
GCP
AMERICAN ASSOCIATION
TCEBS FOR THE ACCREDITATION PHARMACEUTICALS
cGMP
OF LABORATORY
ANIMAL CARERECON
dlbs1 DLBS
YLTM
033TM 0847TM
DLBS2
411TM SILFAM
Indonesian striat DLBS
INTM
0533TM
Modern DLBS3
233TM DLBS1
DLBS
0333TM
inTM
Herbal 422TM AVOMI
NO LTM
Medicines DLBS
5447TM
Produced from
Indonesian raw
materials using the OBAT NYERI KEPALA HERBAL
Bioactive Fractionation
technology.
OBAT HERBAL UNTUK KEMBUNG DAN MUAL1 strip @ 6 kapsul 100 mg Meeting the International Standards HACCP
Our Intelectual Properties: 42 patents and 1250+ trademarks worldwide
Stimuno®
Helps to restore immune system
STIMUNO is an herbal supplement made of herb’s extract from Phyllanthus niruri. The activity
of the plant on immune system has been evaluated in several preclinical studies. It is shown that
the extract of Phyllanthus niruri L. can modulate the immune system through the proliferation and Phyllanthus
activation of T and B lymphocytes, the secretion of specific cytokines such as interferon-γ, TNF-α
niruri L
(tumor necrosis factor-α), interleukin, as well as the activation of the complement system and
phagocytes such as macrophages and monocytes. The cytotoxic activity of natural killer (NK) cells is
increased.
STIMUNO®is the only immunomodulator certified as a phytopharmaca from Indonesian National Agency for
Drug and Food Control. Phytopharmaca certification is given only to herbal products containing standardized
extract with efficacy proven by clinical trial.. Stimuno is recommended to supports immune system function.
Several clinical studies have also been conducted to assess the immunomodulatory effects in some cases,
such as pulmonary TB (tuberculosis), hepatitis B, upper respiratory tract infections, herpes zoster, acute
exacerbation of chronic obstructive pulmonary diseases (COPD), and vaginal candidiasis.
Direction for use:
Adults and children 12+ years: 1 capsule 3 times daily
Children 1+ years: 1 teaspoonful (5 ml), 3 times dailyLagerstroemia
Inlacin speciosa
Helps to reduce blood glucose level
for Diabetes and PCOS
Cinnamomum
Inlacin, contains proprietary active ingredients, namely DLBS3233 burmannii
50 and 100 mg, herbal bioactive extracts which effectively acts as an
insulin sensitizer. Molecularly, this product upregulates the gene
expression of PPARγ, PI3 Kinase, Akt, and GLUT-4, which are associated
with insulin signal transduction pathway and insulin resistance. Clinical
trial data also shows that it reduces HbA1c significantly by 1.13%.
Inlacin® is recommended not only for diabetics but also for those who with
high risk to diabetes. The product is also safe for long-term use. Addition it
can be used singly or concomitantly with other diabetic medication. Inlacin
is the first anti-diabetic that has been registered as Fitofarmaka, since 2015.
Direction for use:
50 mg once daily for prevention or newly diagnosed
100 mg once daily for diabetic patientsDisolf
Helps to improve blood circulation
Disolf, an enteric-coated tablet contains 490 mg DLBS1033 bioactive
protein extract. It has been shown to have anti-thrombosis activity due to
Lumbricus terrestris
its anti-platelet aggregation and fibrinogenolitic activity. The
thrombolytic activity of the protein extract was seen by clot lysis assay
and its direct fibrinolytic activity also confirmed by zymogram method
and fibrin disk method. In addition, DLBS1033 increased
thrombolytic activity compared to negative control in clot lysis
percentage (pRedacid
Cinnamomum burmannii
Helps to alleviate hyperacidity
in dyspepsia and GERD conditions
Redacid is a product that gives anti-ulcer activity. It contains
DLBS2411 250 mg, which is produced with a standardized and
a patented processed. This product effectively works as a proton
pump (H+/K+ ATPase) expression downregulator that reduces the
excessive gastric acid in the stomach that causes the development
of ulcer. In addition, DLBS2411 also has mucoprotective capacity.
This product is proven to be safe and recommended to be used by
people who have stomach problems related to alcoholism, stress or
drug-induced ulcers. Redacid currently registered as Fitofarmaka in
Indonesia.
Direction for use:
Mild pain: 1 caplet
Moderate to severe pain: 1-3 capletsChanna striata
Herba Asimor
Increases breast
milk production
HERBAASIMOR contains a combination of bioactive fraction GALATONOL
Coleus
amboinicus
300 mg and a bioactive protein fraction STRIATIN 30 mg. Galatonol as a
galactogenic agent could stimulate breast milk production, resulting
in the increased of body weight in pups and also prolactin and
Sauropus
oxytocin released in lactating rats, according to pre-clinical androgynus
studies. In addition, STRIATIN supports lactating mother due to
its nutritional content.
Direction for use:
1 tablet, 2 times dailyHerbapoten Eurycoma
longifolia
Helps to maintain
stamina in men
HerbaPOTEN contains bioactive fraction DLBS0555 200 mg.
This bioactive fraction has been proven to generate sexual
performance, libido, general wellness and stress and mood
parameters. Along with the efficacy, clinical studies have also
recorded the well-tolerated safety profile of HerbaPOTEN.
Direction for use:
1 caplet dailyDismeno Phaleria macrocarpa Helps to relieve menstrual pain (dysmenorrhea) DISMENO contains bioactive extract DLBS1442 100 mg per capsule, which has been proven to help treat endometriosis by inhibiting inflammation and abnormal growth of blood vessels in the endometrium. In vivo study in rats proved reduction in size of cyst in the rat’s endometrium. Another animal study showed reduced oedema using rats-induced carrageenan models. Toxicology studies have ascertained that this drug is safe to be consumed. Direction for use: 1 capsule, 3 times daily
Inbumin Possesses a very good wound healing and provides medical nutrition needs INBUMIN is a second brand of POSAFIT, which also contains bioactive protein fraction STRIATIN 250 mg. It mainly contains non-albumin proteins and also Channa striata amino acids as well as other nutrients which are potential for accelerate wound healing in conditions such as post-surgery and post-partum condition as well as increasing albumin level. Thus, consuming STRIATIN is a better option to improve albumin levels in this condition. The main mechanisms of wound healing effect of STRIATIN are via cell proliferation enhancement and serum albumin level improvement. A preclinical study of STRIATIN has been conducted in vitro and in vivo to show its effect on cell growth, acceleration of wound area recovery, improvement of serum albumin level and the inhibitory activity of HMG-CoA reductase and ACE. Directions for use: 1 tablet, 2 times daily
Vitex
trifolia
Abrus
precatorius
Herbakof
Helps to relieve cough and soothe throat
Phaleria
macrocarpa
HerbaKOF is a cough natural medicine containing a bioactive
extract DLBS08E40 otherwise known “Reconyl” 225 mg/15 ml,
which effective in relieving cough, ease mucus secretion, and
open up respiratory congestion. In addition, HerbaKOF also
available in film-coated tablet dosage form. Herbakof® is
Zingiber
officinale safe for use by adults and children.
Directions for use:
15 ml of syrup, 3 times daily
1 tablet, 3 times dailyPhaleria macrocarpa Herbacold Nigella sativa Helps to relieve cold symptom which is accompanied by sore throat HerbaCOLD is a product that contains bioactive extract DLBS0533. It has effectively stimulates the immune system, which is can lead to prevention and the cold to heal. In addition, HerbaCOLD is also an efficacious anti-inflammation agent. This product is proven to be safe for all ages and recommended to be used for people with cold and sore throat symptoms. Direction for use: 1-2 tablets daily
Herbavomitz Helps to relieve Zingiber officinale bloating and nausea HerbaVOMITZ contains bioactive extract DLBS5447 150 mg, an innovation by DLBS research that combines the benefit of nature and advances technology. It has a direct effect on the gastrointestinal tract to relieve anti-flatulence, nausea and vomit. DLBS5447 is safe for all ages and during pregnancy, as well as breastfeeding. HerbaVOMITZ currently is commercialized in two dosage form: tablet and syrup. Directions for use: 10 ml, 1-3 times daily 1-3 tablets daily
Herbapain Helps to relieve Phaleria macrocarpa headache and muscle pain HerbaPAIN® contains bioactive fraction DLBS1442 200 mg. This bioactive fraction has been proven to generate anti-inflammation activity, which helps to reduce pain. Our study has shown that it has direct effect on headache, muscle pain, and back pain. Furthermore, the safety study also confirmed that DLBS1442 is safe to be consumed. Direction for use: 1-3 tablets daily and when required
DLBS Products Presence & Customers
Therapeutic Classification Customer Therapeutic Classification Customer Therapeutic Classification Customer
Other Drugs used Diabetologist, Internist, Drugs for Peptic Ulcer Gastroenterologist, Antithrombotic Agents Cardiologist, Neurologist,
in Diabetes ObsGyn, GP and Gastro-Oesophageal Internist, GP Internist, Diabetologist. GP
Reflux Disease
Therapeutic Classification Customer Therapeutic Classification Customer Therapeutic Classification Customer
Other Gynecologicals ObsGyn, GP Cough Suppressants GP, Consumer (OTC) All Other Pediatrician, GP,
(Dysmenorrhea) and Expectorants Therapeutic Products Consumer (OTC)
(Immunomodulator)You can also read
