Forever. heartbreak Beat - British Heart Foundation

 
Beat
heartbreak
           forever.
Research Grant
Awards 2018      bhf.org.uk
Contents

      02 Introduction

      03 BHF Chairholders

      06 Awards made during the year
         April 2016 – 31 March 2017
      06    Non-clinical Fellowships
      10    Clinical Fellowships
      12    Regenerative Medicine Centres
      12    Infrastructure Grants
      13	Special Project Grants
      14	Clinical Study Grants
      14    Programme Grants
      16	New Horizons Grants
      16    Translational Awards
      16    Project Grants
2            British Heart Foundation                                           Research Grant Awards 2017/18                                                                                                           BHF Chairholders   3

Introduction                                                                                                                        BHF chairholders
                                                                                                                                    Listed by town
In the year April 2017 to March 2018 the British                                                                                      University of Birmingham                           University of Cambridge
Heart Foundation (BHF) awarded grants                                                                                                 The Chair of Cardiovascular Sciences and           The Chair of Epidemiology and Medicine
                                                                                                                                      Cellular Pharmacology                              Held by: Professor J N Danesh MBChB MSc
totalling £108.4 million* for research into the                                                                                       Held by: Professor S P Watson                      DPhil FMedSci
causes, prevention, diagnosis and treatment                                                                                           BSc PhD FMedSci
                                                                                                                                                                                         Major interests: Cardiovascular epidemiology;
of diseases of the heart and circulation.                                                                                             Major interest: Cellular and molecular biology     large-scale studies of genetic and biochemical
                                                                                                                                      of blood platelets in haemostasis and              factors.
                                                                                                                                      thrombosis.
                                                                                                                                                                                         University of Cambridge
                                                                                                                                      University of Bristol                              The Chair of Cardiovascular Medicine
             The BHF has five research grant committees,                        The Clinical Studies Committee held its first         The Chair of Cardiac Surgery                       Held by: Professor Z Mallat MD PhD
             each of which meets up to four times a year.                       meeting in May 2017 to support clinical trials of     Held by: Professor G D Angelini
                                                                                                                                      MD MCh FRCS FETCS FMedSci                          Major interest: Cellular and molecular control
             The members of each committee are experts in                       treatments, diagnostics and other interventions
                                                                                                                                                                                         of immune processes in atherosclerosis
             various aspects of basic and clinical                              and certain observational studies of specific
                                                                                                                                      Major interests: Coronary artery bypass surgery,   and vascular inflammation.
             cardiovascular research. Applications are sent                     patient groups. The Committee awarded £3.6
                                                                                                                                      including off-pump techniques and methods to
             to independent reviewers before being                              million to three applications.
             assessed by the committee. Judgements are
                                                                                                                                      reduce restenosis; improving surgery for heart     University of Cambridge
                                                                                The Translational Awards Committee awarded            defects in infants.
             made on factors such as scientific merit,                                                                                                                                   The Chair of Cardiopulmonary Medicine
             relevance to cardiovascular disease, timeliness,                   £1.2 million to five applications for the
             relationship to other work in the field, and value                 development of cardiovascular research                University of Bristol                              Held by: Professor N W Morrell MBBS BSc
                                                                                                                                                                                         MA MD FRCP FMedSci
             for money. Shortlisted applicants for                              through early pre-clinical milestones, with the
                                                                                                                                      The Chair of Congenital Heart Surgery
             intermediate and senior Fellowships are                            aim of advancing the research to be attractive                                                           Major interest: Molecular and genetic
                                                                                                                                      Held by: Professor M Caputo MD MCh FRCS
             interviewed.                                                       for larger follow-on investment.                                                                         mechanisms of pulmonary arterial hypertension.
                                                                                                                                      from 1 October 2017
             In 2017-2018 the Chairs and Programme Grants                       The Fellowships Committee awarded £32.2
             Committee awarded £50.4 million to Personal                        million to 82 applications, and the Project
                                                                                                                                      Major interests: Cardiac surgical research,        University of Edinburgh
                                                                                                                                      particularly in congenital heart disease.
             Chairs, Programme Grants, Infrastructure                           Grants Committee awarded £21.3 million to 98                                                             The Chair of Translational
             Grants and other major projects. This included                     applications.                                                                                            Cardiovascular Sciences
             £7.5 million to provide a second round of                                                                                University of Bristol                              Held by: Professor A H Baker BSc PhD FMedSci
                                                                                The pages that follow list BHF chairholders in
             funding to three BHF Centres of Regenerative                                                                             The Chair of Cardiovascular Science
                                                                                post, and new awards made for Fellowships,                                                               Major interest: Gene- and cell-based
             Medicine, £3 million towards the National                                                                                Held by: Professor C Emanueli BSc PhD
                                                                                Regenerative Medicine Centres, Infrastructure                                                            therapies to combat vascular disease.
             Prevention Research Initiative, and £2 million
                                                                                Grants, Special Project Grants, Clinical Study        Major interest: Growth and repair of adult
             towards Health Data Research UK awards for
                                                                                Grants, Programme Grants, New Horizons
             the analysis of big data. It also included
                                                                                Grants, Translational Awards and Project
                                                                                                                                      blood vessels: roles of stem cells and             University of Edinburgh
             £327,054 towards six data science awards                                                                                 angiogenic factors.
                                                                                Grants.                                                                                                  The John Wheatley Chair of Cardiology
             jointly funded with The Alan Turing Institute.

             There were 31 chairholders (also referred to as
                                                                                Full details of all types of award offered by the     University of Cambridge                            Held by: Professor D E Newby BA BSc PhD
                                                                                                                                                                                         BM DM DSc FRSE FESC FACC FMedSci
                                                                                BHF and the application process appear on the
             BHF Professors) in post on 31 March 2018. Each                                                                           The Chair of Cardiovascular Sciences
                                                                                BHF website bhf.org.uk/research                                                                          Major interest: Experimental cardiovascular
             chairholder is site-visited every five years to                                                                          Held by: Professor M R Bennett BSc MBChB
             assess past research performance, future plans                                                                           PhD MA FRCP FAHA FMedSci                           medicine, including studies of air pollution
             and proposed expenditure. The visiting team                                                                                                                                 as a risk factor for cardiovascular disease.
             includes internationally renowned scientists.                                                                            Major interest: Molecular mechanisms
                                                                                                                                      controlling smooth muscle cell proliferation,      University of Glasgow
                                                                                                                                      ageing and death in atherosclerosis.
                                                                                                                                                                                         The Chair of Cardiovascular Medicine
                                                                                                                                                                                         Held by: Professor R M Touyz BSc MBBCh
                                                                                                                                                                                         MSc PhD FMedSci

                                                                                                                                                                                         Major interest: Vascular mechanisms
                                                                                                                                                                                         of hypertension, particularly the role
                                                                                                                                                                                         of reactive oxygen species.

All of the figures above include supplements made to new and existing grants.

* This figure includes only the expected payments to the next milestone for grants which are conditional upon the
   successful achievement of project milestones.
4   British Heart Foundation                         Research Grant Awards 2017/18                                                                                                     BHF Chairholders   5

    University of Leeds                              King’s College London                            University College London                         University of Oxford
    The Chair of Cardiovascular                      The Chair of Cardiology                          The Vandervell Chair of Congenital Heart          The Chair of Medicine and Epidemiology
    and Diabetes Research                            Held by: Professor K Otsu MD PhD FAHA            Disease (to 30th September 2017)                  Held by: Professor Sir Rory Collins MSc MBBS
    Held by: Professor M T Kearney                   FMedSci                                          Held by: Professor J E Deanfield BA BChir         LMSSA FRCP FMedSci FRS
    MB ChB FRCP DM                                                                                    MB FRCP FMedSci
                                                     Major interest: Inflammatory mechanisms                                                            Major interests: Meta-analysis and large-scale
    Major interest: Mechanisms by which insulin      in heart failure.                                Major interest: Evaluating the risk factors for   trials in cardiovascular disease; large-scale
    resistance and diabetes exacerbate                                                                atherosclerosis and quantifying the progression   epidemiological studies of risk factors
    atherosclerosis.                                 King’s College London                            of vascular disease in children                   and biomarkers.
                                                                                                      and young adults.
                                                     The Chair of Cardiology
    University of Leeds                                                                                                                                 University of Oxford
    The Chair of Cardiovascular Imaging
                                                     Held by: Professor A M Shah MD FRCP
                                                     FESC FMedSci
                                                                                                      University of Manchester                          The Chair of Regenerative Medicine
    Held by: Professor S Plein MRCP MD PhD                                                            The Chair of Cardiac Physiology                   Held by: Professor P R Riley BSc PhD FMedSci
                                                     Major interest: Cellular and molecular biology   Held by: Professor D A Eisner MA DPhil
    Major interest: Innovative cardiac magnetic      of production of reactive oxygen species in      FMedSci                                           Major interests: Developmental biology of the
    resonance imaging for patient diagnosis          the cardiovascular system and their roles                                                          heart and its applications to cardiac
    and assessment.                                  in atherosclerosis, cardiac hypertrophy          Major interest: Cellular and molecular            regenerative medicine.
                                                     and heart failure.                               physiology of the role of calcium in control
    University of Leicester                                                                           of heart rhythm.                                  University of Oxford
    The Chair of Cardiac Surgery
                                                     King’s College London                                                                              The Chair of Cardiovascular Medicine
    Held by: Professor G J Murphy BSc                The John Parker Chair of
                                                                                                      University of Manchester                          Held by: Professor H C Watkins MD PhD
    MBChB MD FRCS                                    Cardiovascular Sciences                          The Chair of Cardiology                           FRCP FMedSci FRS
                                                     Held by: Professor Q Xu MBBS MD PhD              Held by: Professor B D Keavney BSc BM BCh
    Major interest: Strategies to reduce distal                                                       MRCP DM FRCP                                      Major interests: Genetics and underlying
    organ injury occurring during cardiac surgery.   Major interest: Cellular and molecular biology                                                     molecular mechanisms in hypertrophic
                                                     of stem cells and their importance in            Major interest: Genetics of heart disease.        cardiomyopathy; genetics of coronary
    Imperial College London                          modulating atherosclerosis and restenosis.                                                         artery disease.

    The Simon Marks Chair of
                                                                                                      University of Oxford
    Regenerative Cardiology
                                                     King’s College London                            The Chair of Cardiovascular Medicine
                                                                                                                                                        University of Southampton
    Held by: Professor M D Schneider                 The Chair of Cardiovascular Proteomics           Held by: Professor S Bhattacharya MBBS            The Chair of Cardiovascular Science
    MD FMedSci                                       Held by: Professor M Mayr MD PhD from            MD MRCP MSc FESC FMedSci                          Held by: Professor M A Hanson MA DPhil
                                                     1 May 2017                                                                                         CertEd FRCOG
    Major interests: Molecular control of cardiac                                                     Major interests: Developmental biology of the
    myocyte growth and death; strategies for         Major interest: Novel methods to detect          heart; cardiovascular drug target discovery.      Major interest: Molecular mechanisms for
    regenerative cardiac medicine.                   and measure biomarkers of cardiovascular risk.                                                     developmental and neonatal origins of adult
                                                                                                      University of Oxford                              cardiovascular disease.
    King’s College London                            Queen Mary, University                           The Chair of Cardiovascular Medicine
    The Chair of Molecular Cardiology                of London                                        Held by: Professor B Casadei MD DPhil
                                                                                                                                                        University of Swansea
    Held by: Professor M Gautel MD PhD FMedSci                                                        FRCP FESC FMedSci                                 The Sir Thomas Lewis Chair of
                                                     The Chair of Cardiovascular Immunology
                                                                                                                                                        Cardiovascular Science
    Major interest: Cellular and molecular biology   Held by: Professor F M Marelli-Berg MD PhD       Major interest: Redox signalling in               Held by: Professor A J Williams BA PhD
    of the contractile proteins in heart muscle.                                                      cardiovascular disease, particularly atrial
                                                     Major interest: Control of T lymphocyte homing
                                                                                                      fibrillation.                                     Major interests: Molecular biology of calcium
                                                     to the heart in rejection, autoimmunity and
                                                                                                                                                        flux through the ryanodine receptor in cardiac
                                                     inflammation.
                                                                                                      University of Oxford                              myocytes and its disturbance in arrhythmia.

                                                                                                      The Field Marshal Earl Alexander
                                                                                                      Chair of Cardiovascular Medicine
                                                                                                      Held by: Professor K M Channon MD FRCP
                                                                                                      FMedSci

                                                                                                      Major interests: Redox signalling in
                                                                                                      atherosclerosis; using genetics and genomics
                                                                                                      to discover novel molecular pathways in
                                                                                                      atherosclerosis.
6           British Heart Foundation                           Research Grant Awards 2017/18                                                                                                                                      Fellowships                7

Awards made during the year
1 April 2017 – 31 March 2018
Fellowships                                                                                                                  Immediate Postdoctoral Basic Science Research Fellowships

Listed alphabetically by Institute                                                                                           Reference number   Name               Institution           Grant title                                              Total

                                                                                                                             FS/18/5/33319      Dr M Katsoulis     University            Weight change and the onset and progression of           £246,519
Non-clinical Fellowships                                                                                                                        PhD                College London        cardiovascular diseases in large-scale electronic
Senior Basic Science Research Fellowships                                                                                                                                                health records. 4 years
Reference number      Name               Institution      Grant title                                           Total
                                                                                                                             FS/17/59/33117     Dr D Tsiantoulas   University of         The role of APRIL (A Proliferation Inducing Ligand)      £240,221
FS/18/1/33234         Dr J Johnson       University       The role of the GM-CSF receptor CSF2RA in             £1,046,617                      BSc PhD            Cambridge             in myocardial infarction. 3 years
                      MSc PhD            of Bristol       inflammatory cardiovascular diseases. 5 years
                                                                                                                             FS/18/24/33424     Dr R Tyser         University            Initiation of the first heartbeat: from single cell      £267,013
FS/18/19/33371        Dr M Clarke        University of    Do IL-1R2 and inflammatory caspases regulate          £479,983                        BSc PhD            of Oxford             calcium oscillations to propagating waves. 4 years
                      BSc PhD            Cambridge        IL-1 in senescence and atherosclerosis? 4 years
                                                                                                                             FS/17/37/32937     Dr P Collings      University            Combined associations of sleep duration,               £198,344
FS/17/35/32929        Dr S De Val        University       Determining the regulatory pathways controlling       £1,150,716                      BSc MSc MPhil      of York               sedentariness and intensity-specific physical activity
                      BSc PhD            of Oxford        venous and lymphatic vessel growth and their role                                     PhD                                      with non-communicable disease risk markers in
                                                          during heart development and regeneration.                                                                                     childhood. 4 years
                                                          5 years
                                                                                                                             4-year PhD Studentships
FS/17/55/33100        Dr D Sparrow       University       Investigation of the mechanisms of environmental      £940,865     Reference number   Name               Institution           Grant title                                              Total
                      BSc PhD            of Oxford        causes of congenital heart disease. 5 years
                                                                                                                             FS/17/64/33476     Prof S Harding     Imperial College      ICL 1st intake 2017 – 4-year PhD Studentship (4th)       £669,224
Intermediate Basic Science Research Fellowships                                                                                                 BSc PhD            London                Scheme: Mr Alexander Ainscough; Ms Julia Garcia;
                                                                                                                                                                                         Ms Jennifer Veneta Todorova; Ms Tamzin Zawadzki.
Reference number      Name               Institution      Grant title                                            Total                                                                   4 years

FS/17/36/32874        Dr R Charles       King's College   Activation of soluble epoxide hydrolase by intra-      £672,733    FS/17/65/33481     Prof M Mayr        King's College        KCL 1st intake 2017 – 4-year PhD Studentship (4th)       £661,580
                      PhD                London           protein disulfide formation: role in regulating                                       MD PhD             London                Scheme: Ms Jessica Chandler; Mr Daniel Koch; Mr
                                                          cardiovascular function in health and disease.                                                                                 Mihai Pruna; Ms Ella Reed. 4 years
                                                          5 years

                                                                                                                             FS/17/69/33484     Prof A Ahluwalia   Queen Mary,           QMUL 1st intake 2017 – 4-year PhD Studentship (4th) £649,024
FS/17/57/32934        Dr M Stroud        King's College   Understanding the role of the nuclear envelope in      £719,417                       BSc PhD            University of         Scheme: Mr Joshua Dignam; Ms Shireen Mohammad;
                      BSc PhD            London           cardiovascular development and disease. 5 years                                                          London                Ms Nur Mousa; Mr Stefan Russo.
                                                                                                                                                                                         4 years
FS/18/20/33449        Dr M Nixon         University       Adipose glucocorticoid exposure is regulated by        £675,929
                      BSc PhD            of Edinburgh     proteolytic cleavage of corticosteroid binding                     FS/17/70/33482     Prof A Hughes      University            UCL 1st intake 2017 – 4-year PhD Studentship (4th)  £663,924
                                                          globulin (CBG). 5 years                                                               BSc MBBS PhD       College London        Scheme: Ms Annalisa Bettini; Ms Jasmine Gratton; Ms
                                                                                                                                                                                         Maria Maranon; Mr Michael Magnussen. 4 years
FS/17/56/32925        Dr N Helassa       University       CALM HEART. Investigating the role of calmodulin       £578,581
                      PhD                of Liverpool     in cardiac arrhythmia. 5 years                                     FS/17/60/33474     Prof A Poole       University            Bristol 1st intake 2017 – 4-year PhD Studentship (4th)   £610,876
                                                                                                                                                MA PhD VetMB       of Bristol            Scheme: Ms Tessa Forbes; Mr Michael Mosley; Ms
FS/18/4/33310         Dr C Pinali        University of    An ultrastructural study to elucidate how             £723,660                        FBPhS MRCVS                              Audrys Pauza; Mr Kurt Taylor. 4 years
                      PhD                Manchester       proteoglycans determine the elastic properties of the
                                                          cardiac extracellular matrix in health and disease.                FS/17/61/33473     Dr M Bennett       University            Cambridge 1st intake 2017 – 4-year PhD Studentship       £664,424
                                                          5 years                                                                               BSc MBChB PhD      of Cambridge          (4th) Scheme: Ms Anna Francis; Ms Alice Sowton;
                                                                                                                                                MA FRCP FAHA                             Ms Jennifer Leggat; Ms Robyn Macrae. 4 years
FS/17/58/33072        Dr L Heather       University       Lipids: dysregulated signalling molecules in the       £628,379                       FMedSci
                      BSc DPhil          of Oxford        type 2 diabetic heart? 5 years                                     FS/17/62/33477     Prof M Bailey      University            Edinburgh 1st intake 2017 – 4-year PhD Studentship (4th) £624,376
                                                                                                                                                BSc PhD FRSB       of Edinburgh          Scheme: Ms Viktoria Balogh; Ms Loes Elemans; Ms Iris
FS/18/3/33292         Dr A Lewandowski   University       Cardiac remodelling in preterm-born offspring:         £658,359                                                                Prunonosa-Cervera; Mr Benjamin Thomas. 4 years
                      BSc DPhil          of Oxford        defining the importance of early postnatal changes
                                                          and potential for neonatal dietary interventions to                FS/17/63/33485     Prof R Touyz       University            Glasgow 1st intake 2017 – 4-year PhD Studentship         £607,316
                                                          reduce long-term risk. 5 years                                                        BSc MBBCh MSc      of Glasgow            (4th) Scheme: Mr Simon Fisher; Ms Erin Higgins; Ms
                                                                                                                                                PhD FMedSci                              Alice Main; Ms Kayley Scott. 4 years
FS/18/2/33221         Dr J Serbanovic    University       Role of the mechanoreceptor Pkd1 in endothelial        £389,932
                      Canic              of Sheffield     dysfunction and atherosclerosis. 5 years
                      PhD
8          British Heart Foundation                               Research Grant Awards 2017/18                                                                                                                                   Fellowships               9

4-year PhD Studentships (continued)                                                                                             PhD Studentships (continued)
FS/17/66/33480      Prof P Stewart      University           Leeds 1st intake 2017 – 4-year PhD Studentship (4th) £611,348      FS/17/76/33286     Mr M Hudda          St George's,     Improving assessments of body fatness, overweight        £94,199
                    MD FRCP FMedSci     of Leeds             Scheme: Mrs Yilizila Abudushalamu; Mr Michael Bell;                                   BSc MSc PhD         University of    and obesity in UK children and adolescents of
                                                             Ms Holly Foster; Ms Heba Shawer. 4 years                                                                  London           different ethnic origins. 3 years

FS/17/67/33483      Dr E Cartwright     University           Manchester 1st intake 2017 – 4-year PhD Studentship £607,876       FS/17/28/32807     Ms C Lewis          University       Inhibiting angiogenesis in aortic valves via S1P         £107,465
                    BSc Msc PhD         of Manchester        (4th) Scheme: Ms Abimbola Akerele; Ms Cali                                            BSc                 of Aberdeen      receptors: a new therapeutic target. 3 years
                                                             Anderson; Mr Ryan Potter; Ms Katie Ryding. 4 years
                                                                                                                                FS/17/29/32828     Mr P Harrison       University       Measurement of preplatelets in inherited and             £107,497
FS/17/68/33478      Prof D Greaves      University           Oxford 1st intake 2017 – 4-year PhD Studentship         £659,464                      BSc PhD FRCPath     of Birmingham    acquired thrombocytopenia. 3 years
                    BSc PhD             of Oxford            (4th) Scheme: Ms Lucija Fleisinger; Mr Oliver
                                                             Neely; Ms Helen Potts; Ms Agata Rumianek. 4 years
                                                                                                                                FS/18/9/33388      Miss C Koo          University       Identifying the tetraspanin/ADAM10 ‘molecular            £120,670
                                                                                                                                                   BSc MSc             of Birmingham    scissor’ for the platelet collagen and fibrin receptor
PhD Studentships                                                                                                                                                                        GPVI. 3 years
Reference number    Name                Institution          Grant title                                             Total
                                                                                                                                FS/18/11/33443     Miss R Stapley      University       Investigating the role of SLFN14 in megakaryocyte        £150,698
                                                                                                                                                   BSc                 of Birmingham    and platelet biology. 3 years
FS/17/75/33257      Miss Y Chan         Cardiff University   Investigation of the anti-atherogenic actions of        £107,553
                    BSc                                      (+)-catechin in vivo. 3 years
                                                                                                                                FS/17/38/32935     Miss Z Adams        University       Sex differences in the role of sympathetic nerve         £107,372
                                                                                                                                                   BSc                 of Bristol       activity in the development of hypertension in
FS/17/41/32976      Mr W Bonneuil       Imperial College     Chemokine transport dynamics and vascular disease. £115,303
                                                                                                                                                                                        humans. 3 years
                                        London               3 years

                                                                                                                                FS/17/46/33121     Miss L Reolizo      University       Exploiting the inhibition of vascular smooth muscle      £107,340
FS/17/73/33186      Miss A Francis      Imperial College     The effect of oestrogen on the function and local       £130,822
                                                                                                                                                   BSc                 of Bristol       cell proliferation and intimal thickening by PRH/
                    BSc                 London               environment of the L-type Ca2+ channel. 3 years
                                                                                                                                                                                        HHEX. 3 years

FS/17/74/33192      Ms E Pchenlintseva Imperial College      Acoustic patterning for next-generation drug            £115,558
                                                                                                                                FS/17/42/32978     Ms A Rioja          University       Mechanisms of neovascularisation: signalling from        £107,413
                    BSc                London                screening and cardiac engineering. 3 years
                                                                                                                                                   BSc MSc             of Bristol       VEGFR1 to the cytoskeleton through RhoA. 3 years

FS/17/39/32938      Miss Q Toe          Imperial College     Endothelial cell uptake of decompartmentalised          £118,928
                                                                                                                                FS/18/7/33697      Student to          University       Joint NC3Rs/BHF PhD Studentship: Recreating              £90,000
                    BSc                 London               iron species in Eisenmenger syndrome: implications
                                                                                                                                                   be appointed        of Cambridge     thrombosis models using tissue-engineered arterial
                                                             for disease pathogenesis and treatment. 3 years
                                                                                                                                                   (Supervisor: Dr A                    constructs: a novel method to reduce and replace
                                                                                                                                                   Harper)                              mice used in platelet research. 3 years
FS/17/71/32953      Miss K Dalrymple    King's College       The influence of a complex intervention of diet and     £112,228
                                        London               physical activity in obese pregnant women on the
                                                                                                                                FS/17/32/32916     Mr S Ahmed          University       Does enhanced smooth muscle cell contraction             £105,522
                                                             cardiometabolic phenotype of 3 year old children:
                                                                                                                                                   BSc                 of East Anglia   increase local matrix stiffness and promote smooth
                                                             analysis of the UPBEAT trial. 3 years
                                                                                                                                                                                        muscle cell proliferation? 3 years

FS/17/44/33022      Miss A Wright       Lancaster            Unravelling the mechanisms of apolipoprotein and        £106,353
                                                                                                                                FS/17/27/32698     Miss R Sanders      University       Assessing the regulation and function of long non-       £107,498
                    MSci                University           serum amyloid A aggregation in atherosclerosis.
                                                                                                                                                   BSc MRes MPhil      of Edinburgh     coding RNA LINC00961 in vascular endothelial cell
                                                             3 years
                                                                                                                                                                                        function. 3 years

FS/18/8/33698       Student to be       Manchester           Joint NC3Rs/BHF PhD Studentship: Development            £90,000
                                                                                                                                FS/18/10/33413     Ms F Vacante        University       The functional consequence of miR-143HG loss on      £67,715
                    appointed           Metropolitan         of E-Sense: a flexible in vitro platform to determine
                                                                                                                                                   BSc MSc             of Edinburgh     the development of atherosclerosis. 1 year, 9 months
                    (Supervisor: Dr S   University           cardiovascular risk. 3 years
                    White)
                                                                                                                                FS/17/43/33003     Miss K Miteva       University       The role of Ca2+ signalling in the regulation            £107,808
                                                                                                                                                                       of Leeds         of Weibel-Palade Body trafficking and cargo
FS/17/72/33181      Miss A Bishop       St George's,         Stanniocalcin-1 and vascular remodelling at the         £115,919
                                                                                                                                                                                        secretion. 3 years
                    BSc                 University           maternal / fetal interface. 3 years
                                        of London
                                                                                                                                FS/17/30/32832     Mr B Roper          University       Targeting the LOX-1 (SR-E1) scavenger receptor           £107,879
                                                                                                                                                   MBiolSci            of Leeds         and atherosclerosis using synthetic proteins called
FS/17/40/32942      Ms S                St George's,         Investigations into calcium-sensing receptor            £130,820
                                                                                                                                                                                        Affimers. 3 years
                    Carlton-Carew       University           mechanisms in the vasculature. 3 years
                    BSc                 of London
                                                                                                                                FS/17/45/33102     Miss R Dinsdale     University       Understanding the molecular pharmacology of              £114,803
                                                                                                                                                                       of Oxford        vascular calcium-activated chloride channels.
                                                                                                                                                                                        3 years
10         British Heart Foundation                                 Research Grant Awards 2017/18                                                                                                                                       Clinical Fellowships      11

PhD Studentships (continued)                                                                                                      Clinical Research Training Fellowships (continued)
FS/17/31/32848      Ms G Little          University            Study of the molecular mechanisms that allow the      £116,868     FS/17/82/33322      Dr R Hughes           University College   The extended spectrum of apical hypertrophic          £225,735
                    BSc                  of Reading            collagen-binding chaperone protein HSP47 to                                                                  London               cardiomyopathy. 3 years
                                                               modulate platelet responses to collagen. 3 years
                                                                                                                                  FS/17/34/32901      Dr K Knott            University College   Perfusion mapping in ischaemic heart disease.         £206,139
FS/18/6/33696       Student to be        University            Joint NC3Rs/BHF PhD Studentship: Using                £90,000                          MA MBBS MRCP          London               3 years
                    appointed            of Sheffield          zebrafish embryos to identify genes that protect
                    (Supervisor: Prof                          against atherosclerosis. 3 years
                                                                                                                                  FS/18/18/33522      Dr T Hinton           University           Investigating the role of the carotid body in young   £116,203
                    P Evans)
                                                                                                                                                      BMedSci MBChB         of Bristol           onset hypertension. 2 years
                                                                                                                                                      MRCP
FS/17/33/32931      Mr R Johnson         University of Surrey Investigating arrhythmogenic risk from cardiac         £107,854
                    BSc MBiol                                 cell therapy; scrutinising the effects of human
                                                              myofibroblasts on iPSC-derived cardiomyocyte                        FS/17/49/32917      Dr K Hope             University           Comparing the mechanistic role of carotid bodies      £220,320
                                                              function. 3 years                                                                       BM BS BMedSci         of Bristol           in human heart failure with and without preserved
                                                                                                                                                      MSc FRCA                                   ejection fraction. 3 years

Clinical Fellowships
                                                                                                                                  FS/17/51/33096      Dr J Andrews          University           Early clinical development of a thrombus              £168,504
                                                                                                                                                      MBChB                 of Edinburgh         18
                                                                                                                                                                                                    F-radiotracer. 3 years
Intermediate Clinical Research Fellowships                                                                                                            MRCP
Reference number    Name                  Institution           Grant title                                          Total
FS/18/21/33447      Dr M Fontana          University College    The pathophysiology of cardiac AL amyloidosis:       £717,044     FS/17/79/33226      Dr M Doris            University           Combined positron emission tomography and             £120,628
                    PhD                   London                phenotypic spectrum and clinical significance.                                        MBChB                 of Edinburgh         magnetic resonance imaging of coronary
                                                                5 years                                                                                                                          atherothrombosis. 1 year

FS/18/12/33270      Dr M Bailey           University            Vascular smooth muscle cell Orai1 in abdominal       £515,929     FS/17/50/33061      Mr J Kaczynski        University            F-fluoride positron emission tomography-
                                                                                                                                                                                                 18
                                                                                                                                                                                                                                                   £293,665
                    BSc PhD MB ChB        of Leeds              aortic aneurysm. 5 years                                                                                    of Edinburgh         magnetic resonance imaging in patients with acute
                    PG Cert (Health                                                                                                                                                              neurovascular syndrome. 2 years
                    Research) MRCS
FS/18/22/33479      Dr A Jones            University            Reversibility of early cardiometabolic dysfunction in £763,253    FS/18/25/33454      Dr K Lee              University           High-sensitivity cardiac troponin I and risk          £263,693
                    BSc BM PhD            of Oxford             sedentary and obese adolescents. 5 years                                              MBChB MRCP            of Edinburgh         stratification of patients with suspected acute
                                                                                                                                                                                                 coronary syndrome. 3 years

FS/18/23/33512      Dr M Holmes           University            Drug target validation and risk prediction for       £1,026,833
                    BSc MBBS MRCP         of Oxford             coronary heart disease using targeted                             FS/17/53/33119      Dr T Moullaali        University           Does blood pressure variability (BPV) affect          £168,553
                    MSc PhD                                     blood-based metabolomics and proteomics.                                              MBBS                  of Edinburgh         outcome after stroke due to intracerebral
                                                                5 years                                                                                                                          haemorrhage?. 3 years

FS/18/13/33281      Dr R Thompson         University            The role of double-stranded RNA in pulmonary         £722,505     FS/18/14/33330      Dr A Jackson          University           The epidemiology of peripartum cardiomyopathy         £186,095
                    BMedSci MB ChB        of Sheffield          vascular remodelling. 4 years                                                         BSc MBChB             of Glasgow           in a Western European country: an analysis of the
                    MRCP (UK) PhD                                                                                                                                                                Scottish population 1990-2016. 3 years

                                                                                                                                  FS/17/78/33180      Dr T Slater           University           Examining the effect of increasing endothelial cell £196,816
                                                                                                                                                      MMBS MRCP             of Leeds             insulin like growth factor-1 receptor expression in the
Clinical Research Training Fellowships                                                                                                                                                           endothelium on blood pressure homeostasis and
Reference number    Name                  Institution           Grant title                                          Total                                                                       endothelial cell function in health and diet induced
                                                                                                                                                                                                 type 2 diabetes mellitus. 3 years
FS/18/15/33518      Dr J Kelly            King's College        The role of inflammation in the development of       £144,900
                    BSc MBChB             London                spinal cord ischaemia after thoracoabdominal
                    MRCS                                        aneurysm repair. 2 years                                          FS/18/26/33501      Dr L Athithan         University           Cardiac rest and stress metabolism in patients with £136,122
                                                                                                                                                      MBBCh MRCP            of Leicester         type 2 diabetes. 2 years, 6 months
FS/17/77/33128      Dr F Papalia          King's College        Iron status and cardiac mechano-energetics in        £226,286
                    BMedSci MBBS          London                heart failure. 3 years                                            FS/17/54/33126      Mr N Denham           University           An experimental study regarding the effectiveness     £238 301
                                                                                                                                                      BMBM                  of Manchester        of PDE5 inhibition to prevent atrial fibrillation.
                                                                                                                                                                                                 3 years
FS/18/16/33396      Dr M Ryan             King's College        Evaluation of a novel physiological biomarker of       £245,683
                    BSc MBChB MRCP        London                hibernation in ischaemic left ventricular dysfunction.
                                                                3 years                                                           FS/17/47/32805      Dr J Lagan            University           Why is COPD associated with heart failure?            £126,854
                                                                                                                                                      MA MRCP AFHEA         of Manchester        2 years
FS/17/81/33318      Dr Z Raisi            Queen Mary,           Broken bones and broken hearts: relationships     £231,716
                    Estabragh             University of         between osteoporosis and cardiovascular structure
                                          London                and function in UK Biobank. 3 years
12         British Heart Foundation                              Research Grant Awards 2017/18                                                                                Regenerative Medicine Centres / Infrastructure Grants / Special Project Grants             13

Clinical Research Training Fellowships (continued)                                                                                Special Project Grants
FS/17/52/33113      Dr C Pius             University of      An experimental study on the impact of myocyte       £271,190        Listed alphabetically by Institute
                    MBChB                 Manchester         ultrastructural remodelling on cellular function and
                                                             arrhythmogenesis following an ischaemic episode.                     Reference Number Name                     Location               Grant title                                              Total
                                                             3 years
                                                                                                                                  SP/18/6/33805        Dr S Niederer        The Alan Turing        The BHF-Turing Cardiovascular Data Science Awards £49,310
                                                                                                                                                       DPhil                Institute and King's   (First call): Quantifying functional co-variation in
FS/17/80/33317      Dr S Lockhart         University         Examining the direct vascular actions of the            £200,411                                               College London         calcium handling proteins in cardiac myocytes (joint
                                          of Oxford          glucagon-like peptide-1 analogue liraglutide in                                                                                       funding with The Alan Turing Institute). 1 year
                                                             obese patients with coronary atherosclerosis.
                                                             3 years
                                                                                                                                  SP/18/7/33806        Dr W Astle           The Alan Turing        The BHF-Turing Cardiovascular Data Science Awards £47,362
                                                                                                                                                       MA MMath PhD         Institute and          (First call): Looking for cardiovascular risk factors
FS/18/17/33514      Dr S Monga            University         The effect of altering myocardial lipid content on      £290,431                                               University of          in blood smear images (joint funding with The Alan
                    MBChB MMed            of Oxford          cardiac physiology in patients with aortic stenosis.                                                           Cambridge              Turing Institute). 1 year
                    MRCP DPhil                               3 years

                                                                                                                                  SP/18/5/33804        Dr A Butterworth     The Alan Turing        The BHF-Turing Cardiovascular Data Science               £26,481
FS/17/48/32907      Dr W Watson        University            Altering substrate selection as a potential             £253,679                          BA PhD MSc           Institute and          Awards (First call): Flexible fine-mapping of multiple
                    BSc MBBChir PGCert of Oxford             therapeutic target in heart failure. 3 years                                                                   University of          intermediate traits at cardiovascular disease loci
                    (MedEd) MRCP                                                                                                                                            Cambridge              (joint funding with The Alan Turing Institute). 1 year

                                                                                                                                  SP/18/3/33801        Dr E Di Angelantonio The Alan Turing        The BHF-Turing Cardiovascular Data Science Awards £54,848
                                                                                                                                                       MD PhD MSc           Institute and          (First call): Using machine learning for personalised
                                                                                                                                                                            University of          CVD risk management (joint funding with The Alan
Regenerative Medicine Centres                                                                                                                                               Cambridge              Turing Institute). 1 year
Reference number    Name                  Institution        Grant title                                             Total
                                                                                                                                  SP/18/2/33800        Prof N Mills         The Alan Turing        The BHF-Turing Cardiovascular Data Science Awards £80,529
RM/17/1/33377       Prof S Harding        Imperial College   BHF Centre of Regenerative Medicine (renewal)           £2,500,000
                                                                                                                                                       MBChB BSc PhD        Institute and          (First call): Machine learning in myocardial infarction
                    BSc PhD               London             4 years
                                                                                                                                                       FESC FRCP            University of          to improve risk prediction and inform treatment
                                                                                                                                                                            Edinburgh              decisions (joint funding with The Alan Turing Institute).
RM/17/3/33381       Prof A Baker          University of      BHF Centre of Regenerative Medicine (renewal)           £2,500,000                                                                    1 year
                    BSc PhD               Edinburgh          4 years
                                                                                                                                  SP/18/4/33803        Dr A Doherty         The Alan Turing        The BHF-Turing Cardiovascular Data Science Awards £68,524
RM/17/2/33380       Prof P Riley          University         BHF Centre of Regenerative Medicine (renewal)           £2,500,000                                             Institute and          (First call): Unsupervised learning of physical activity
                    BSc PhD FMedSci       of Oxford          4 years                                                                                                        University of          markers and their association with cardiovascular
                                                                                                                                                                            Oxford                 disease (joint funding with The Alan Turing Institute).
                                                                                                                                                                                                   1 year

                                                                                                                                  SP/17/11/32885       Prof S Cook          Imperial College       Defining the genetics, biomarkers and outcomes           £1,999,834
Infrastructure Grants                                                                                                                                  PhD MRCP             London                 for dilated cardiomyopathy: a prospective multi-
                                                                                                                                                                                                   centre study (GO-DCM). 4 years
Reference number    Name                  Institution        Grant title                                               Total
IG/17/2/32993       Prof S Nourshargh     Queen Mary,        Funds towards the purchase of a multiphoton               £314,211   SP/17/10/33219       Prof M Mayr          King's College         ERA-CVD 'transnational research projects on              £249,492
                    BSc PhD FMedSci       University of      confocal microscope. 1 year                                                               MD PhD               London                 cardiovascular diseases': non-coding RNAs in
                                          London                                                                                                                                                   cardiac macrophages and their role in heart failure.
                                                                                                                                                                                                   3 years
IG/18/2/33544       Prof S Watson         University of      Funds towards six items of imaging equipment at           £754,233
                    BSc PhD FMedSci       Birmingham         the Centre of Membrane Proteins and Receptors                        SP/18/1/33797        Health Data          Medical Research       Joint funding towards Health Data Research UK            £2,000,000
                                                             (COMPARE) at the Universities of Birmingham and                                           Research UK          Council                (HDRUK) awards. 5 years
                                                             Nottingham. 1 year

                                                                                                                                  SP/17/9/33243        UK Prevention        Medical Research       Joint funding towards the National Prevention            £3,000,000
IG/18/1/33458       Prof D Newby       University of         Funds to upgrade and expand a radiochemistry              £700,000                        Research             Council                Research Initiative. 3 years
                    BA BSc PhD BM DM   Edinburgh             facility to deliver current and future cardiovascular                                     Partnership
                    DSc FRSE FESC FACC                       PET research. 2 years
                    FMedSci
                                                                                                                                  SP/17/12/32960       Prof D Newby         University of          Duration of dual anti-platelet therapy in acute          £630,845
                                                                                                                                                       BA BSc PhD BM        Edinburgh              coronary syndrome across Scotland: the DUAL-
IG/17/3/33201       Dr S Semple           University of      Funds to upgrade a BHF-funded 3T magnetic                 £393,225                        DM DSc FRSE FESC                            ACS2 trial. 5 years
                    BSc PhD MSc           Edinburgh          resonance imaging scanner. 1 year                                                         FACC FMedSci
14         British Heart Foundation                              Research Grant Awards 2017/18                                                                                            Special Project Grants / Clinical Study Grants / Programme Grants         15

Special Project Grants (continued)                                                                                                Programme Grants (continued)
                                                                                                                                  RG/17/16/33294    Prof P Eaton          King's College         Furthering our understanding of PKGIα in              £999,700
SP/18/8/33620        Dr T Webb           University of        ERA-CVD 'transnational research projects on            £249,829
                                                                                                                                                    BSc PhD               London                 cardiovascular health and disease. 5 years
                     BSc MRes PhD        Leicester            cardiovascular diseases': druggable MI genes:
                                                              utilising myocardial infarction genes for better
                                                              treatment. 3 years                                                  RG/17/15/33106    Prof M Shattock       King's College         The Na/K ATPase in cardiovascular health              £1,199,974
                                                                                                                                                    BSc PhD FRCP (Edin)   London                 and disease. 4 years
SP/17/15/33490       Dr P Quinlan        University of        Joint funding with MRC: UKCRC Tissue Directory         £75,000
                                         Nottingham           and Coordination Centre Phase II. 3 years                           RG/17/7/33217     Prof P Mortimer       Medical Research       Joint funding with MRC: Deep phenotyping to           £750,000
                                                                                                                                                    MD FRCP               Council                improve understanding of causal mechanisms and
                                                                                                                                                                                                 underlying gene mutations in primary lymphoedema
SP/17/16/33519       Prof K Channon      University of        The NIHR-BHF Cardiovascular Partnership.               £112,705
                                                                                                                                                                                                 and lymphatic malformations. 5 years
                     MD FRCP FMedSci     Oxford               3 years

                                                                                                                                  RG/17/5/32936     Dr S Sinha            University             New therapeutic strategies for Marfan and other       £1,271,390
SP/17/13/33347       Prof R McManus      University of        Seventh Joint Stroke Association/BHF Grant:            £1,109,564
                                                                                                                                                    BA MB BChir           of Cambridge           genetically-triggered aortic aneurysm syndromes.
                     MSc MA (Oxon)       Oxford               Towards An Integrated Self-Monitoring SolutIoN
                                                                                                                                                    MRCP PhD                                     5 years
                     PhD MBBS FRCGP                           for Stroke/TIA: TASMIN5S (Ninth call). 5 years

                                                                                                                                  RG/17/8/32924     Prof D Giussani       University             Cardiovascular dysfunction in the hypoxic fetus:      £1,311,663
SP/17/14/33355       Dr H Gallagher      University of        Joint funding with NIHR (Health Technology             £750,000
                                                                                                                                                    MA PhD ScD            of Cambridge           intervention by mitochondria-targeted antioxidants.
                     MA MSc PhD FRCP     Southampton          Assessment (HTA) Programme): Aspirin To Target
                                                                                                                                                    FRCOG                                        (Renewal). 5 years
                                                              Arterial events in Chronic Kidney disease – the
                                                              ATTACK trial. 7 years, 6 months
                                                                                                                                  RG/17/12/33167    Prof S Ozanne         University             Insulin and hypoxia: key determinants in the          £1,103,850
                                                                                                                                                    BSc Hons PhD          of Cambridge           programming of cardiovascular disease by
                                                                                                                                                                                                 maternal obesity. 5 years

Clinical Study Grants                                                                                                             RG/17/11/33042    Prof D Beech          University             Endothelial Piezo1 channel in whole body physical     £1,383,429
Listed alphabetically by Institute                                                                                                                  BSc PhD FMedSci       of Leeds               activity and cardio-metabolic protection. 5 years

Reference Number Name                    Location             Grant title                                            Total        RG/17/9/32812     Prof G Murphy         University             Towards the prevention of post cardiac surgery        £1,399,996
                                                                                                                                                    BSc MBChB MD          of Leicester           organ failure. 5 years
CS/17/6/33361        Prof D Werring      University College   OPTIMAS: OPtimal TIMing of Anticoagulation             £2,045,998
                                                                                                                                                    FRCS
                     BSc MBBS FRCP PhD   London               after AF-associated acute ischaemic Stroke:
                                                              a randomised controlled trial. 5 years
                                                                                                                                  RG/18/2/33392     Prof M Boyett         University of          Control of ion channel expression in the cardiac      £1,316,626
                                                                                                                                                    BSc PhD FRSB FRCP     Manchester             conduction system in disease: search for potential
CS/17/4/33009        Dr R Gardner        University of        How do arrhythmias and conduction disturbances         £429,737
                                                                                                                                                                                                 new therapeutic targets. (Renewal). 5 years
                     MBChB MD            Glasgow              contribute to death or rehospitalisation in patients
                     MRCP FESC                                discharged following an admission with acute heart
                                                              failure? A prospective, observational, multi-centre                 RG/18/1/33351     Prof S Bhattacharya   University             Precision therapeutics for cardiovascular             £1,004,873
                                                              cohort study. 4 years, 6 months                                                       MBBS MD MRCP          of Oxford              inflammation. 5 years
                                                                                                                                                    MSc FESC FMedSci
CS/17/5/32826        Prof T Robinson     University of        Tenecteplase in Wake-up Ischaemic Stroke Trial         £323,014
                     MD FRCP FESO        Leicester            (TWIST). 3 years                                                    RG/17/10/32859    Prof K Channon        University             Non-canonical roles for tetrahydrobiopterin in        £1,399,658
                     AFHEA                                                                                                                          MD FRCP FMedSci       of Oxford              cardiovascular disease pathogenesis. 5 years

                                                                                                                                  RG/17/14/33085    Prof D Paterson       University             Cyclic nucleotide coupled phosphodiesterase           £617,619
Programme Grants                                                                                                                                    MA MSc DPhil DSc
                                                                                                                                                    FRSB FPhysiol Hon
                                                                                                                                                                          of Oxford              signalling in cardiac sympathetic neurons in heart
                                                                                                                                                                                                 disease: novel therapeutic targets. 3 years
Listed alphabetically by Institute                                                                                                                  FRSNZ

Reference number     Name                Institution          Grant title                                            Total        RG/18/5/33532     Prof P Riley          University             Epicardial activation and signalling during           £588,176
RG/18/3/33405        Dr J Crawley        Imperial College     Protein S-TFPI anticoagulant pathway: molecular        £1,271,273                     BSc PhD FMedSci       of Oxford              cardiovascular repair: comparing regenerative
                     BSc PhD             London               mechanisms and therapeutic potential. 5 years                                                                                      and non-regenerative models: programme
                                                                                                                                                                                                 extension. (Renewal). 3 years

RG/17/13/33173       Prof J Gorelik      Imperial College     Function follows form: improving the failing heart by £1,081,461
                     MSc PhD             London               targeting signalling nanodomains in myocytes. 5 years               RG/17/6/32944     Prof M Zaccolo        University             Topography, regulation and function of PDE-     £1,226,593
                                                                                                                                                    MD                    of Oxford              dependent cAMP nanodomains in cardiac myocytes.
                                                                                                                                                                                                 (Renewal). 5 years
RG/18/4/33541        Prof J Mitchell     Imperial College     Understanding the COX-2/prostacyclin/NO axis           £995,313
                     BSc PhD             London               in the cardiovascular system. 5 years
16          British Heart Foundation                               Research Grant Awards 2017/18                                                                                            New Horizons Grants / Translational Awards / Project Grants              17

New Horizons Grants                                                                                                                 Project Grants (continued)
                                                                                                                                    PG/17/22/32868     Prof J Crawley      Imperial College      The role of VWF-dependent platelet ‘priming’ and         £196,861
Reference number Name                   Institution          Grant title                                                Total
                                                                                                                                                       BSc PhD             London                neutrophil recruitment in DVT. 2 years
NH/18/1/33511         Dr V Muthurangu   University College   Towards comprehensive assessment of heart disease          £291,881
                      BSc MD(Res)       London               in children using real-time cardiovascular magnetic
                                                                                                                                    PG/18/17/33572     Dr J Crawley        Imperial College      The structural basis of ADAMTS13 allostery.              £294,048
                      MRCPCH                                 resonance. 2 years
                                                                                                                                                       BSc PhD             London                2 years, 6 months

                                                                                                                                    PG/18/19/33584     Dr R de Groot       Imperial College      ADAMTS7 and cardiovascular disease: identifying          £180,799
                                                                                                                                                       BSc MSc PhD         London                molecular mechanisms. 2 years
Translational Awards
Listed alphabetically by Institute                                                                                                  PG/17/81/33345     Dr J Keegan         Imperial College      Arrhythmia insensitive whole-heart late gadolinium       £239,908
                                                                                                                                                       BSc MSc PhD         London                enhancement (LGE) MRI for assessment of native,
Reference number Name                   Institution          Grant title                                                Total                                                                    surgical and post-ablation scar tissue in patients
                                                                                                                                                                                                 with heart rhythm disturbance. 3 years
TG/16/2/32657        Prof P Chowienczyk King's College       First-phase ejection fraction as a diagnostic              £146,961
                     BSc MBBS FRCP      London               marker and therapeutic target in cardiac disease.
                                                             2 years                                                                PG/17/57/33130     Dr N Latif          Imperial College      Role of the mechanosensitive ion channel Piezo1          £126,567
                                                                                                                                                       BSc PhD             London                in human valve endothelial cells. 2 years

TG/16/1/32108        Dr P Lamata        King's College       Improving the identification of faulty valves.             £245,076
                     PhD                London               2 years                                                                PG/17/42/33039     Dr I Salles-Crawley Imperial College      BAMBI and its role in the anticoagulant function of      £97,016
                                                                                                                                                       BSc MSc PhD         London                the endothelium. 1 year

TG/16/3/32687        Dr G Gray          University           11βHSD1 inhibition: a distinctive acute-MI                  £318,737
                     BSc PhD FBPhS      of Edinburgh         intervention for promotion of peri-infarct vascularisation,            PG/17/61/33187     Prof C Terracciano Imperial College       Mechanosensitive molecular mechanisms of                 £97,140
                     FRSB                                    reduction of infarct expansion                                                            MD PhD             London                 myocardial fibrosis: a multicellular approach.
                                                             and prevention of heart failure. 2 years                                                                                            1 year, 6 months

TG/16/3/32687        Dr D Adlam         University           Development of a prototype pericardial left ventricular £249,771       PG/17/60/33168     Dr S Wort           Imperial College      The role of H3K27 methylation in vascular endothelial    £193,282
                     BA BM BCh DPhil    of Leicester         assist device. 2 years                                                                    MA (Oxon) MBBS      London                cell proliferation and function: implications for
                     FRCP                                                                                                                              FRCP PhD FFICM                            pulmonary arterial hypertension.
                                                                                                                                                                                                 2 years

TG/16/3/32687        Dr L Ebah          University           Transdermal Fluid Removal (TFR): a novel community- £134,293
                     MD MRCP PhD        of Manchester        based and patient self-administered treatment for fluid                PG/18/2/33446      Prof L Zhao         Imperial College      Investigation of selective HDAC6 inhibitor, C1A, as      £164,885
                                                             overload in heart failure.                                                                MD PhD              London                a treatment for pulmonary arterial hypertension.
                                                             2 years                                                                                                                             2 years

                                                                                                                                    PG/17/38/33024     Dr S Chapple        King's College        Activation of Nrf2 antioxidant defences by               £240,505
                                                                                                                                                       BSc PhD             London                sulforaphane confers vascular protection in
                                                                                                                                                                                                 offspring exposed to a maternal obesogenic diet.
Project Grants                                                                                                                                                                                   3 years
Listed alphabetically by Institute
                                                                                                                                    PG/17/50/32903     Prof P Chowienczyk King's College         Partitioning the determinants of pulse pressure into     £275,269
Reference number Name                   Institution          Grant title                                                Total                          BSc MBBS FRCP      London                 those due to ventricular ejection and characteristics
                                                                                                                                                                                                 of the arterial tree. 3 years
PG/18/15/33566       Dr J Ahnstrom      Imperial College     Regulation of versican procoagulant role by ADAMTS-        £223,603
                     BSc MSc PhD        London               mediated proteolysis. 3 years
                                                                                                                                    PG/17/44/33064     Prof P Eaton        King's College        An investigation of the potential therapeutic effects    £290,749
                                                                                                                                                       BSc PhD             London                of Sulforadex in Noonan syndrome. 3 years
PG/17/33/32990       Dr G Birdsey       Imperial College     VEGF-dependent angiogenesis requires activation of         £130,472
                     BSc PhD            London               specific isoforms of the ETS transcription factor ERG.
                                                             1 year, 6 months                                                       PG/17/65/33215     Dr T Kampourakis    King's College        Cardiac thick filament modulators: a potential new       £145,956
                                                                                                                                                       PhD Dipl            London                class of heart failure therapeutics. 1 year, 3 months
PG/18/3/33515        Dr A Bottle        Imperial College     Using large databases to describe the current            £222,035
                     BSc (Hons) MSc     London               management of heart failure in England and model risk                  PG/17/37/33023     Dr A Kapustin       King's College        KLF4 regulates VSMC migration and proliferation          £131,410
                     PhD                                     trajectories to improve shared decision-making. 2 years,                                  BSc PhD             London                via exosomes. 1 year, 6 months
                                                             6 months
                                                                                                                                    PG/17/79/33313     Dr J Liu            King's College        Functional characterisation of the human                 £76,615
PG/17/71/33242       Dr J Boyle         Imperial College     Development of a fluorescent reporter probe for            £213,438                       AB PhD              London                congenital heart disease gene RAPGEF5. 1 year
                     BSc MBChB          London               enzyme-activity of heme oxygenase 1 (HO-1).
                     PhD FRCPath                             2 years, 3 months
18         British Heart Foundation                               Research Grant Awards 2017/18                                                                                                                                             Project Grants              19

Project Grants (continued)                                                                                                          Project Grants (continued)
PG/17/53/33079      Prof G Lombardi     King's College       Targeting recipient antigen-presenting cells with sialic    £269,742   PG/18/21/33599     Dr C Watson          Queen's University   Epigenetic changes in hypoxic cardiac fibroblasts:          £153,454
                    BSc PhD             London               acid-modified alloantigen to promote transplantation                                      BSc PhD PGDip        Belfast              implications for DNA methylation in the pathogenesis
                                                             tolerance. 3 years                                                                        UT&L                                      of ischaemic heart disease. 2 years

PG/17/48/32956      Prof M Mayr         King's College       AortOMICS: proteomics-based assessment of thoracic          £238,948   PG/18/10/33550     Dr R Bell            University College   Sodium / glucose transporters in the heart and their      £283,777
                    MD PhD              London               aneurysm formation. 3 years                                                               BSc PhD MBBS         London               role in hyperglycaemic exacerbation of ischaemia /
                                                                                                                                                       MRCP                                      reperfusion injury following acute myocardial infarction.
                                                                                                                                                                                                 3 years
PG/18/6/33530       Dr M Pfuhl          King's College       Dissecting the activation mechanism of titin kinase by      £278,787
                    PhD                 London               NMR spectroscopy. 3 years
                                                                                                                                    PG/17/88/33401     Dr K Brown           University College   Using National Congenital Heart Diseases Audit data £289,840
                                                                                                                                                       BA MB BChir          London               to explore the impact of non-medical risk factors on
PG/17/51/32950      Dr M Robson         King's College       Novel pathways involving ANCA and monocytes in              £292,415
                                                                                                                                                       MRCP MSC MD                               late post-operative outcomes for children with complex
                    MRCP PhD            London               ANCA vasculitis. 3 years
                                                                                                                                                                                                 congenital heart defects. 3 years

PG/17/52/33059      Dr W Wong           King's College       Prolonging cardiac allograft survival by targeting          £246,748
                                                                                                                                    PG/17/90/33415     Prof A Hughes        University College   Cardiovascular mechanisms linked to cerebral amyloid £273,844
                    BSc MBBS MRCP       London               the indirect antigen presentation pathway with an
                                                                                                                                                       BSc MBBS PhD         London               β deposition and cognitive decline: a sub study of
                    DPhil                                    immunotoxin. 2 years
                                                                                                                                                                                                 INSIGHT 46. 2 years, 6 months

PG/17/39/33027      Dr M Zhang          King's College       The modulation of cAMP/PKA signalling by cardiac            £232,715
                                                                                                                                    PG/17/47/32963     Dr V Muthurangu      University College   Harnessing the potential of magnetic resonance              £211,432
                    MD PhD              London               NOX2. 3 years
                                                                                                                                                       BSc MD (Res)         London               augmented cardiopulmonary exercise testing (MR-
                                                                                                                                                       MRCPCH                                    CPET) in pulmonary arterial hypertension. 3 years
PG/17/67/33218      Dr S White          Manchester           Defining the mechanisms of normal and pathological          £234,445
                    BSc DPhil           Metropolitan         force sensing by endothelial cell adhesion complexes.
                                                                                                                                    PG/17/70/33232     Prof C Ruhrberg      University College   VEGF signalling pathways in vascular permeability.          £120,360
                                        University           3 years
                                                                                                                                                       PhD                  London               1 year

PG/17/36/33021      Prof R Corder       Queen Mary,          Identification of the constitutive, secretory-pathway,      £132,151
                                                                                                                                    PG/18/22/33604     Dr K Sutcliffe       University College   Children’s and parents’ informed and willing consent        £112,707
                    BSc MSc PhD         University of        endothelin-converting enzyme. 2 years
                                                                                                                                                       BA MSc PhD           London               to heart surgery. 1 year, 6 months
                    MRPharmS            London

                                                                                                                                    PG/17/20/32864     Prof I Zachary       University College   Role of Bcar1/p130Cas in heart development.                 £245,846
PG/17/82/33368      Dr L Green          Queen Mary,          A pragmatic pilot randomised control trial of               £170,929
                                                                                                                                                       BSc PhD              London               3 years
                    MBBS MSc (HRM)      University of        prothrombin complex concentrates versus fresh frozen
                    MD (Res) FRCP       London               plasma in adult patients who are undergoing heart
                    FRCPath                                  surgery (PROPHESY). 2 years, 3 months                                  PG/17/87/33400     Prof I Zachary       University College   Investigation of the role of Bcar1/p130Cas in               £187,454
                                                                                                                                                       BSc PhD              London               atherosclerosis. 2 years
PG/17/74/33111      Prof A Hobbs        Queen Mary,          Defining a pivotal role for endothelium-derived C-type      £245,430
                    BSc PhD             University           natriuretic peptide in angiogenesis and vascular                       PG/17/64/33205     Dr D Dawson          University           A randomised, double-blind placebo controlled            £299,169
                                        of London            remodelling. 3 years                                                                      DM FRCP DPhil        of Aberdeen          trial to test if a beneficial effect of beta-blockers on
                                                                                                                                                       FESC                                      exacerbations of chronic obstructive pulmonary disease
                                                                                                                                                                                                 (COPD) is restricted to those patients with occult
PG/17/85/33395      Prof S Nourshargh   Queen Mary,          Impact of mast cells on neutrophil-pericyte interactions £238,442
                                                                                                                                                                                                 heart disease. 3 years
                    BSc PhD FMedSci     University           and neutrophil effector functions: role of IL-17A?. 3 years
                                        of London
                                                                                                                                    PG/17/30/32961     Prof Dr P Kirchhof   University           Impact of chronic intermittent hypoxia on atrial resting £203,196
                                                                                                                                                       MD FESC FRCP         of Birmingham        membrane potential and NaV1.5 channel function:
PG/17/41/33038      Dr D Przulj         Queen Mary,          Time-restricted eating as a weight loss intervention in     £61,574
                                                                                                                                                       (Edin)                                    a new mechanism for causing atrial fibrillation. 3 years
                    PhD                 University           obese adults: a pilot study. 1 year
                                        of London
                                                                                                                                    PG/17/55/33087     Dr D Pavlovic        University           Cardiotonic steroids in patients with atrial fibrillation   £172,818
                                                                                                                                                       BSc DPhil FHEA       of Birmingham        and heart failure: quantification, functional effects
PG/17/59/33139      Prof A Tinker       Queen Mary,          Ric8b: a modulator of heterotrimeric G-protein              £143,054
                                                                                                                                                                                                 and personalisation of digoxin therapy. 2 years
                    BA MB BS FRCP       University           signalling and its role in cardiovascular physiology.
                    PhD FMedSci         of London            2 years
                                                                                                                                    PG/17/34/32996     Dr M Bond            University           Nuclear action dynamics and vascular cell behaviour.        £190,161
                                                                                                                                                       BSc PhD              of Bristol           3 years
PG/17/40/33028      Prof T Warner       Queen Mary,          Re-evaluating the effects of aspirin on the                 £239,026
                    BSc PhD             University           cardiovascular system. 3 years
                                        of London                                                                                   PG/17/66/33216     Prof S George        University           Attenuation of intimal thickening via porcupine             £140,074
                                                                                                                                                       BSc PhD              of Bristol           inhibition. 3 years
PG/17/91/33428      Dr C Watson         Queen's University   Investigating the role of tetranectin in cardiac            £242,517
                    BSc PhD PGDip       Belfast              remodelling and its utility as a heart failure biomarker.
                    UT&L                                     3 years
20        British Heart Foundation                           Research Grant Awards 2017/18                                                                                                                               Project Grants               21

Project Grants (continued)                                                                                                 Project Grants (continued)
PG/17/89/33414     Prof J Hancox      University       Drug-induced hERG potassium channel inhibition:          £207,792   PG/17/63/33198     Dr M Reed          University     The IPED (Investigation of Palpitations in the             £21,347
                   BSc PhD FRSB       of Bristol       novel access and binding determinants? 3 years                                         MA MB BChir        of Edinburgh   Emergency Department) study: randomised controlled
                   FBPhS                                                                                                                      MRCS FCEM MD                      trial of the use of a smart phone based event recorder
                                                                                                                                                                                versus standard care for patients presenting to
                                                                                                                                                                                the emergency department with palpitations and
PG/17/75/33095     Prof P Madeddu     University       Investigation of a novel proangiogenic mechanism         £148,688
                                                                                                                                                                                pre-syncope. 1 year
                   MD                 of Bristol       centred on miR-532, BACH1, angiopoietin-1 and
                                                       Notch/Dll4 in human pericytes. 2 years
                                                                                                                           PG/17/83/33370     Dr A Tavares       University     Novel imaging biomarker for detection of regional          £276,970
                                                                                                                                              BSc MSc PhD        of Edinburgh   cardiovascular inflammation using positron emission
PG/17/62/33190     Prof S Mundell     University       Regulation of P2Y12 receptor expression and activity     £202,332
                                                                                                                                                                                tomography (PET). 2 years, 6 months
                   BSc PhD            of Bristol       by inhibitory pathways in human platelets: a novel
                                                       mode of action of antiplatelet drugs? 3 years
                                                                                                                           PG/17/54/32981     Dr S Vermeren      University     Dual function of the GTPase-activating protein ARAP3       £237,663
                                                                                                                                              (née Krugmann)     of Edinburgh   in the regulation of endothelial permeability. 3 years
PG/18/8/33540      Dr A Teschemacher University        Development of a strategy to limit lactate-mediated      £117,734
                                                                                                                                              MSc PhD
                   MSc PhD           of Bristol        sympathoexcitation. 1 year, 8 months
                                                                                                                           PG/17/21/32844     Prof T Frayling    University     The genetics of favourable adiposity. 3 years              £234,607
                                                                                                                                              BSc PhD            of Exeter
PG/18/14/33562     Prof M Bennett     University       Development of 3D finite element analysis and            £246,185
                   BSc MBChB PhD      of Cambridge     imaging to predict human atherosclerotic plaque
                   MA FRCP FAHA                        instability. 3 years                                                PG/17/26/32881     Prof G Baillie     University     Targeting PDE3/4 to allow regulation of cardiac            £117,375
                   FMedSci                                                                                                                    BSc PhD            of Glasgow     calcium homeostasis in disease. 2 years

PG/17/45/33071     Dr M Harper        University       The role of the mitochondrial permeability transition    £164,274   PG/17/25/32884     Prof C Berry       University     CORonary MICrovascular Angina (CorMicA): a                 £297,478
                   MA PhD             of Cambridge     pore in procoagulant platelets. 2 years                                                BSc MB ChB PhD     of Glasgow     mechanistic pilot trial and nested MRI sub-study.
                                                                                                                                              FRCP (Gla) FRCP                   3 years
                                                                                                                                              (Edin) FACC FESC
PG/17/58/33134     Dr W Li            University       Role of BMP9 in protecting pulmonary vascular            £136,266
                   BSc PhD            of Cambridge     integrity: implication in sepsis and acute respiratory
                                                       distress syndrome (ARDS). 2 years                                   PG/18/9/33548      Dr C Loughrey      University     Investigating the therapeutic potential of RUNX1           £285,403
                                                                                                                                              BVMS PhD FHEA      of Glasgow     for myocardial infarction. 3 years
                                                                                                                                              MRCVS
PG/17/69/33229     Dr X Li            University       Investigating the role of PLK1 in regulating             £182,399
                   MD PhD             of Cambridge     inflammation. 2 years
                                                                                                                           PG/17/23/32850     Prof J McMurray    University     The effects of sacubitril / valsartan compared             £292,604
                                                                                                                                              BSc MB ChB MD      of Glasgow     to valsartan on left ventricular remodelling in patients
PG/18/20/33595     Prof Z Mallat      University       Regulatory pathways that control Type-2 innate           £284,752
                                                                                                                                              FRCP FESC FACC                    with asymptomatic left ventricular systolic dysfunction
                   MD PhD             of Cambridge     lymphoid cells in atherosclerotic and ischaemic
                                                                                                                                              FAHA FRSE                         after myocardial infarction: a randomised, double-
                                                       heart disease. 3 years
                                                                                                                                                                                blinded active-comparator cardiac-MR based trial.
                                                                                                                                                                                2 years
PG/17/73/33251     Dr M Nus           University       Targeting marginal zone B cells to protect against       £292,736
                   BSc PhD            of Cambridge     atherosclerosis. 3 years
                                                                                                                           PG/18/13/33558     Prof T Quinn       University     Use and impact of the pre-hospital 12-lead                 £196,500
                                                                                                                                              MPhil RN FRCN      of Kingston    electrocardiogram in the primary PCI era: mixed
PG/17/80/33343     Dr K               University       The role of dietary potassium in regulating salt         £166,513                      FESC FAHA FACC                    method study (PHECG-2) 1 year, 6 months
                   O'Shaughnessy      of Cambridge     transport across the DCT in the kidney. 2 years
                   MA BM BCh DPhil
                                                                                                                           PG/17/84/33372     Dr S Calaghan      University     The caveolar coat complex as a mediator of                 £128,308
                   FRCP FHEA
                                                                                                                                              BSc PhD            of Leeds       mechano-sensation in the heart 2 years

PG/17/24/32886     Dr S Sinha         University       Heterogeneity of the human epicardium: molecular         £183,375
                                                                                                                           PG/17/72/33255     Dr A Maqbool       University     Attenuating cardiac inflammation and remodelling           £270,111
                   BA MB BChir        of Cambridge     determinants and functional consequences.
                                                                                                                                              BSc PhD            of Leeds       by targeting the Tenascin C - TLR4 axis. 3 years
                   MRCP PhD                            2 years

                                                                                                                           PG/17/27/32928     Dr R Pease         University     Identifying the origin of plasma FXIII-A and defining      £268,898
PG/17/46/32880     Dr S Robinson      University       Deciphering the angiogenic tug-of-war between            £182,222
                                                                                                                                              BA PhD             of Leeds       the roles of cellular FXIII-A. 3 years
                   PhD                of East Anglia   neuropilin-1 interacting integrins: phase II. 2 years

                                                                                                                           PG/17/28/32943     Prof J Schneider   University     Cardiac microstructure beyond diffusion tensor             £185,541
PG/18/26/33589     Dr V MacRae        University       How does NPP1 ablation drive arterial                    £176,162
                                                                                                                                              Dipl Phys PhD      of Leeds       imaging. 3 years
                   BSc PhD            of Edinburgh     calcification? 2 years
22        British Heart Foundation                          Research Grant Awards 2017/18                                                                                                                               Project Grants              23

Project Grants (continued)                                                                                                  Project Grants (continued)
PG/17/43/33041     Dr C Stover         University      C5L2: regulator of fatty liver disease? 2 years          £60,707     PG/18/4/33521      Dr R Burton       University     Elucidating the interactions between IP3-dependent       £202,761
                   MD PhD              of Leicester                                                                                            BSc MSc MBA       of Oxford      Ca2+ release and Ca2+ stimulated adenylyl cyclases in
                                                                                                                                               DPhil FRSA                       controlling atrial function. 3 years
PG/17/86/33399     Prof S Allan        University      The VWF/ADAMTS13 axis as a potential therapeutic         £168,819
                   BSc PhD             of Manchester   target in the treatment of thrombo-inflammation in                   PG/18/11/33552     Prof K Dora       University     The role of aquaporins in determining the water barrier £128,045
                                                       stroke. 2 years, 4 months                                                               BSc PhD MA        of Oxford      in coronary arteries. 1 years, 6 months

PG/17/29/32945     Prof M Boyett       University      Why does heart block occur at night (especially          £212,171    PG/17/68/33247     Dr J Hartmann-    University     Systematic review of weight regain after intentional   £142,943
                   BSc PhD FRSB        of Manchester   in athletes)? 3 years                                                                   Boyce             of Oxford      weight loss and its impact on cardiovascular and other
                   FRCP                                                                                                                        DPhil MA BA                      related health outcomes. 2 years

PG/18/12/33555     Prof K Brennan      University      PKCα: a potential new therapeutic target for             £175,314    PG/18/1/33430      Prof C Monaco     University     Role of IRF5 in the function of CD11c+ macrophages       £259,681
                   BA MA PhD           of Manchester   cardiovascular disease. 2 years                                                         MD PhD            of Oxford      in atherosclerosis. 2 years

PG/18/24/33608     Dr K Dibb           University      Understanding the structural and functional properties £226,543      PG/18/16/33570     Dr C Reith        University     Cholesterol Treatment Trialists' (CTT) Collaboration:    £174,204
                   BSc PhD             of Manchester   of atrial Ca2+ release sites, how they are remodelled in                                BSc MBChB         of Oxford      meta-analyses of individual participant adverse
                                                       heart failure and the consequences for atrial function                                  FRCP (Gla) FFPM                  event data from randomised controlled trials of statin
                                                       and arrhythmias. 3 years                                                                                                 therapy. 2 years

PG/17/32/32987     Dr H Dobrzynski     University      Detailed 3D modelling of human cardiac anatomy           £118,243    PG/17/49/33099     Dr M Trivella     University     Systematic reviews on the prognostic role of             £129,967
                   BSc PhD             of Manchester   with emphasis on the conduction system using micro-                                     BSc MSc DPhil     of Oxford      biomarkers in heart failure. 2 years
                                                       computer tomography and mathematical modelling
                                                       techniques: variation with ageing and heart failure.
                                                                                                                            PG/18/18/33574     Dr E Tzima        University     PECAM as a novel regulator of cardiac function.          £272,121
                                                       2 years
                                                                                                                                               PhD               of Oxford      3 years

PG/18/5/33527      Dr G Galli          University      Maladaptive cardiac remodelling in adult                 £247,233
                                                                                                                            PG/17/76/33082     Prof J Gibbins    University     Connexins as regulators of platelet function:            £245,653
                   BSc PhD             of Manchester   offspring from hypoxic pregnancies: role of
                                                                                                                                               BSc PhD           of Reading     investigation of the mechanisms of action in the
                                                       cellular calcium homeostasis. 3 years
                                                                                                                                                                                control of haemostasis and thrombosis. 3 years

PG/18/7/33535      Dr A Greenstein     University      Junctophilin 2 as a cytoskeletal anchor facilitating     £214,963
                                                                                                                            PG/17/56/33115     Prof P Evans      University     Role of endothelial STAT5A in focal vascular             £226,798
                   BSc MBChB           of Manchester   vascular smooth muscle cell ion channel cross-talk.
                                                                                                                                               BSc MSc PhD       of Sheffield   inflammation and atherosclerosis. 3 years
                   MRCP PhD                            3 years

                                                                                                                            PG/18/23/33605     Dr A Lawrie       University     Investigating the sex-dependent role of                  £158,377
PG/17/78/33304     Dr D Oceandy        University      Targeting the Hippo pathway to enhance the               £221,780
                                                                                                                                               BSc PhD           of Sheffield   macrophage subtypes in the development
                   MBChB PhD           of Manchester   regenerative capacity of iPS-derived cardiomyocyte.
                                                                                                                                                                                of pulmonary arterial hypertension. 2 years
                                                       3 years

PG/17/77/33125     Dr H Shiels         University      Cardiotoxicity of polycyclic aromatic hydrocarbons       £297,549
                   BSc MSc PhD         of Manchester   (PAHs). 3 years

PG/17/35/33001     Prof M              University      Translating signals from genome-wide association          £298,431
                   Tomaszewski         of Manchester   studies into biological mechanisms of hypertension –
                   MD FAHA FRCP                        expression quantitative trait locus analysis in the human
                                                       kidney. 2 years, 6 months

PG/17/31/32988     Dr X Wang           University      Investigating prolylcarboxypeptidase (PRCP) cascade in £266,843
                   MB ChB PhD          of Manchester   attenuating oxidative stress and mitochondrial damage:
                                                       is PRCP a suitable target for treating heart failure?
                                                       3 years

PG/18/25/33587     Prof I Spyridopoulos University     Role of CX3CR1 and T-lymphocytes in myocardial           £158,765
                   MD                   of Newcastle   ischaemia / reperfusion injury. 2 years
                                        upon Tyne
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