Hyaluronic Acid Experts - Disamed

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Hyaluronic Acid Experts - Disamed
Hyaluronic Acid Experts
Hyaluronic Acid Experts - Disamed
S P E CIAL I S T S I N T H E DE VE LOP M E NT,
P R O D U C T I ON A N D DIST R IB U T ION OF
Hya l ur o n i c a c i d - b a se d pr o du c t s

      2007                2008                 2011                2013                   2015              2016               2017                    2018               2019                2020

      Creation of        Launch of           Launch of         Opening of new           Launch of           Opening     Launch of an innovative    Launch of a new        Opening of        Extension of
Laboratoires VIVACY   Aesthetics range,   Gynecology range,   production site in   dermocosmetics range,   of Geneva     RFID-based product       generation injection   London and     production site and
   in Paris, France     STYLAGE®             DESIRIAL®        Archamps, France     STYLAGE ® SKIN PRO      subsidiary    authenticity method,      delivery system,       Moscow        opening of subsidiary
                                                                                                                          VIVACY Security ®           Bi-SOFT®           subsidiaries        in Warsaw

PRODUCTS                                                                                                   IN TERN ATIO N AL PRESEN CE
                                                                                                           Distrib ution networks in
• STYLAGE® : medical devices used for aesthetic medicine.
• DESIRIAL® : medical devices used for functional and aesthetic gynecology.
• STYLAGE® SKIN PRO : premium range of hyaluronic acid-based dermocosmetics.

                                                                                                                                                                                          over

                                                                                                                                                                                         75
                                                                                                                                                                                        countries
Hyaluronic Acid Experts - Disamed
ON LY A U TH E N T I C PRODUCTS

                                                                                                                                       VIVACY SECURITY ® tags with integrated RFID

OU R                                                                                                                            (Radio Frequency Identification) chips are placed inside
                                                                                                                                 each box to easily verify the origin of STYLAGE ® and

E X C L U SIVE                                                                                                                              DESIRIAL ® injectables with a Smartphone
                                                                                                                                       through a dedicated mobile app, “My Vivacy”.

TE CH N OLOGIES                                                                                                                       Download for free on AppStore and GooglePlay.

        Quality and safety have always been
                                                                                                                                               N E X T-G E N E R ATI ON SYRINGES
              a part of the VIVACY DNA.

  As a manufacturer, Laboratoires VIVACY controls all                                                                                  In its continuing quest for innovative excellence,
  stages of production and no compromise is made.                                                                                   VIVACY developed Bi-SOFT ® Injection Technology
                                                                                                                                   to provide greater precision, comfort and control for
  Our global mission is to introduce innovations that                                                                                 Physicians during their day-to-day injections with
 provide new services and types of experiences to the                                                                                                       STYLAGE ® dermal fillers.
             Medical Aesthetics Industry.

                     Why is this?
Because new technologies can dramatically influence
    the way a product is chosen to safely perform                                                                                              PATE N TE D H YA L U RONIC ACID
                 aesthetic treatments.

                                                                                                                                        STYLAGE ® products are based on the unique
                                                                                                                                 patented IPN-Like Technology¹ to accurately define
                                                                                                                                each product’s viscoelastic properties. Antioxidants are
                                                                                                                                 then added to the HA gels to preserve the formulation
                                                                                                                                  from scavenging free radicals during the injection² ³.

                                                        1
                                                            IPN-Like Technology Patent delivered WO2009/071697 in 2008.
                                                        2
                                                            Smirnoff, N., Cumbes, Q. J. “Hydroxyl radical scavenging activity of compatible solutes”. Journal of Phytochemistry (1989) Vol. 28, no. 4: 1057-1060.
                                                        3
                                                            Mendoza G & Al. “Inhibitory effects of different antioxidants on hyaluronan depolymerisation” Carbohydrate Research 342 (2007); 96-102.
Hyaluronic Acid Experts - Disamed
B i-S O F T ®
INJ E C T I O N T EC H N O LOGY
                                           B i- M AT E R IA L T E CH N OL OG Y
                                           •   Made of po lycar bona t e .
                                           •   A « so ft -t o uch » s u rfa c e .
                                           •   Highly t r ansparent m a t e r i a l .
                                           •   Designed in 5 diffe re nt
                                                                                         OP T I M I S E D C E N T E R OF G R AV I T Y
                                               co lo r-co des to qu i c kl y             • Erg o n o mi c de si g n fo r i n c re a se d p hy s i c i a n ’s
                                               identify the produc t s.                   c om for t .
                                                                                         • A l a rg e r o v a l g ri p pl a t e fo r b e t t e r ha nd l in g
                                                                                          o f t h e sy ri n g e a n d a n e a si e r pro du c t
                                                                                          a dmi n i st ra t i o n .

In its continuing quest for   innovative
excellence in Medical Aesthetic market,
Laboratoires VIVACY has developed a
  unique delivery system, Bi-SOFT ®
         Injection Technology.

                  greater
     The syringe offers
precision , comfort and control .
  It is specifically designed to support
   physicians in the daily practice of
         aesthetic treatments.

                                                                                                               I N J E C TI ON V OL U M E C ONTROL
                                                                                                               • Top d ow n bl u e g ra du a t i on .
                                                                                                               • G ood re a d a b i l i t y.

                                           HA ND L ING A B IL IT Y
                                           • R educt io n o f t he inj e c t i on
                                             fo rce sensat io n.
                                           • Provides extra grip and stability 
                                             between the surface of the
                                             syringe and the gloves.
Hyaluronic Acid Experts - Disamed
IPN-LIKE TECHNOLOGY                                                                                                                                                                                                                                         PRODUCT RHEOLOGY

                     Our patented IPN-Like Technology consists of 2 interpenetrated networks of                                                                                                                           IPN-Like Technology² accurately defines each products
         monophasic cross-linked hyaluronic acid. The cross-linking action stabilizes the hyaluronic                                                                                                        viscoelastic properties. The elastic and viscous components allow the gel to obtain the
                               acid in order to increase the longevity of the product in the tissues¹.                                                                                                           desired properties³: ability to lift, mechanical support and ease of spreading.

                                                                                                     Monophasic cross-linked network A                                  Monophasic cross-linked network B

                                                          +                                                              =
     Monophasic cross-linked network A                                Monophasic cross-linked network B                                     Interpenetrated networks:
               Monophasic
Monophasic cross-linked network A                                        Monophasic
                                                                 Monophasic cross-linked network B                                         Interpenetrated networks:
                                                                                                                                          Monophasic IPN-Like Network
              cross-linked network A                                   cross-linked network B                                           Monophasic IPN-Like Network

        THE IN T E R PE N E T R AT ION
                          Interpenetrated networks:
        O F CROMonophasic
                 SInterpenetrated
                    S Monophasic
                        - L IIPN-Like
                               NK     ENetwork
                                         D Network
                                  networks:
                                     IPN-Like NE T WORK S E NAB LE S²:                                                                                                                                                                    THE I NJECTI ON PLAN

                                                                                                                                                                                                                         is determined by the aesthetic indication that needs to be treated.
            The optimization of product rheology and, in particular, the viscosity to guarantee good “injectability”.                                                                                                Once it has been determined, the physician may choose the STYLAGE®
            The conservation of the partial independence of the interpenetrated networks, whilst increasing the                                                                                                           hyaluronic acid dermal filler with the most adapted rheological
            density of chemical nodes, to limit the degradation of the gel and optimize its duration.                                                                                                                                        properties for the procedure.
            The cohesion of the hyaluronic acid gel and its monophasic properties.

                                                                                                                                                                                                                             All STYLAGE® products contain an antioxidant, Mannitol or Sorbitol*, which
                                                                                                                                                                                                                             protects the hyaluronic acid gel against Free Radicals (oxidative stress) which
 1

 2
   Tezel, A et al. “The science of hyaluronic acid dermal fillers”. Journal of Cosmetic and Laser Therapy (2008); 10: 35-42.
   IPN-Like Technology Patent WO2009/071697 in 2008.
                                                                                                                                                                                                                             are generated during injections³. It also minimizes the degradation of the gel4.
 3
   Sundaram, H. et al.. “Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications”. American Society of Plastic Surgeons (2013). DOI: 10.1097.
 4
   Mendoza G & Al. “Inhibitory effects of different antioxidants on hyaluronan depolymerisation” Carbohydrate Research 342 (2007); 96-102.
 * STYLAGE ® Hydromax only
Hyaluronic Acid Experts - Disamed
CO M P L E T E
      D E R M A L F I L L ER R A NGE

                                                                                                                                     Wrinkle filling & smoothing

                           S TYL E                                              Y O UR      AGE!                                     Lip enhancement

              A full range of monophasic injectable dermal fillers cross-linked using VIVACY’s
                                                                                                                                     Facial volume restoration
                                                       patented IPN-Like Technology*               W ith o r witho ut LIDOCA INE**

                                                                                                                                     Skin hydration & elasticity improvement

* Except STYLAGE ® Hydro which is non-cross-linked
** STYLAGE ® XXL, STYLAGE ® Hydro and STYLAGE ® Hydromax are not available with Lidocaine
Hyaluronic Acid Experts - Disamed
S TYL A G E ® D ER M A L FILLE RS
P R O DU C T R A N G E OVE RVIE W

                                                     M                      L                                    XL                     XXL              HYDRO                    HYDROMAX

                                         Cross-linked HA IPN-Like                          Cross-linked HA IPN-Like              Cross-linked      Non-cross-linked         Cross-linked HA
   Composition                        + Mannitol Option available with                  + Mannitol Option available with         HA IPN-Like             HA                     IPN-Like
                                             Lidocaine (0.3%)                                  Lidocaine (0.3%)                   + Mannitol         + Mannitol                + Sorbitol

   Concentration            16 mg/g              20 mg/g                 24 mg/g        18.5 mg/g             26 mg/g              21 mg/g             14 mg/g                12.5 mg/g

                                                                                                            2 x 1 ml +         2 x 1 ml + 27G½’’                               1 x 1ml +
                          2 x 0.8 ml +          2 x 1 ml +            2 x 1 ml +        1 x 1ml +                                                     1 x 1ml +
   Pack Contents         30G½’’ Needle        30G½’’ Needle         27G½’’ Needle     30G½’’ Needle
                                                                                                          27G½’’ & 23G¼’’     Needle & 25G40mm
                                                                                                                                                    30G ’’ Needle
                                                                                                                                                                            30G ’’ & 30G½’’
                                                                                                             Needles                Cannula                                     Needles

                                                                                                                                Facial volume
                         Fine to Medium       Medium to deep      Deep to very deep                         Facial Volume
   Indications            Wrinkles, Lips       wrinkles, Lips         wrinkles
                                                                                           Lips
                                                                                                             Restoration
                                                                                                                                restoration &                    Moisturisation
                                                                                                                                  creation

                                                                                                                                                      Superficial
                         Superficial to           Mid to               Deep to        Into or around                  Deep dermis or                   dermis/                  Mid to
                          mid dermis            deep dermis       very deep dermis    labial mucosa                   subcutaneous                 dermo-epidermal            deep dermis
                                                                                                                                                       junction

   Depth of Injection

   Duration                                   6 to 12 Months                          6 to 12 Months                  12 to 18 Months                                  --
Hyaluronic Acid Experts - Disamed
FOR HER                                                                                                    FOR HIM

                           S         Glabella

                                                                 Temples       M      XL       XXL

          M    XL        XXL         Temples

                           S         Crow’s Feet

                                                             Cheekbones       XL      XXL

               M           L         Nose
                                                                    Nose       M       L
               XL        XXL         Cheekbones
                                                                             Cheeks   M
                          M          Cheeks
                                                          Nasolabial Folds     M       L

               M           L         Nasolabial Folds
                           S         Perioral area
                                                                     Lips      S      M     SPECIAL LIPS

                S     HYDROMAX       Labial Commissures

          S     M     SPECIAL LIPS   Lips
               XL        XXL         Facial Oval                  Jawline     XL      XXL

                M          L         Marionette lines

                XL       XXL         Chin
                                                                     Chin      XL     XXL

              HYDRO   HYDROMAX       Neck

                L     HYDROMAX       Back of Hand

              HYDRO   HYDROMAX       Décolleté
Hyaluronic Acid Experts - Disamed
WRINKLE FILLING & SMOOTHING

                                             PRODUCT INDICATIONS:
                                       Fill wrinkles and visibly smooth the surface of the skin.

                              for fine (superficial        for moderate to            for deep to very
                              to moderate) lines.            deep lines.                 deep lines.

                                                      INJECTION PLAN:
                              Injection of the gel at a superficial to deep dermis level depending on
                                            product chosen and the area being treated.
Hyaluronic Acid Experts - Disamed
LIP CORRECTION

                           PRODUCT INDICATIONS:
                    Specially designed to treat all indications related to the
                                      ageing of the lips.

                                                 Lip volume augmentation.

                                                 Rehydration of the lips.

                                                 Definition of lip contour.

                                 INJECTION PLAN:
                 Injection into and around the labial mucosa using conventional
                           techniques (retrograde tracing, micro-bolus).
RESTORING VOLUME

                             PRODUCT INDICATIONS:
                    Restore the contours of the face by replenishing volumes that
                                         are lost over time.

                            for facial volume restoration or augmentation.

                                   INJECTION PLAN:
                   Injection into the deep dermis and/or subcutaneously depending
                              on the technique used and the desired effect.
MOISTURISING ACTION

                                  PRODUCT INDICATIONS:
                       Mesotherapy range dedicated to improving skin moisturisation
                                             and elasticity.

                         Non-cross-linked hyaluronic        Cross-linked hyaluronic
                               acid (14mg/g).                  acid (12.5mg/g).

                                        INJECTION PLAN:
                      Injection with multiple micro-injections into the superficial or deep
                           dermis* of the face, neck, décolleté or back of the hand.

                                                                            * Depending on the condition of the skin,
                                                                            the product and the chosen technique
A D D ITION  OF L I D O C AINE
      PATIE N T C O M F OR T
                                                                                                                                                                                                      WANT TO MASTER YOUR
                                                                                                                                                                                                        INJECTION SKILLS?
                   Laboratoires VIVACY developed a formula containing the anesthetic, Lidocaine,
         to make injections less painful and improve the patient’s comfort during the procedure.
               STYLAGE ® “with lidocaine” reduces discomfort at the moment of the injection
                           and guarantees that the product performance is the same as that of
                                                             the products without Lidocaine¹.
                                                                                                                                                                                                                                WA NT T O
                                                                                                                                                                                                                              MA STER Y O UR
                                                                                             100                                                                                                                               INJ E C T IO N
                                                                                                                                                                                                                                 SKI LLS?
                    DISTRIBUTION OF PATIENTS (%)
                   BY LEVEL OF PAIN EXPERIENCED (1)                                                                             STYLAGE ® M

                                                                                              80                                STYLAGE ® M Lidocaine

             60                                                                                                                                                                                                               JOIN FOR FREE & LEARN FROM OUR EXPERTS
                                                                                              60                                                                                                                                    VIVACY-LEARN.COM
             50

             40
                                                                                              40

             30

             20
                                                                                              20

             10

               0                                                                                0
                          Light            Moderate            Strong                                      Light          Moderate             Strong

                                During injection                                                                    During massage
                                                                                                                                                                                                JOIN FOR FREE & LEARN FROM OUR EXPERTS
                                                                                                                                                                                                              V I VA C Y- L E A R N . C OM

                                                                                                                                                                                         HIGH LEVEL    KEY OPINION   4 NEW VIDEOS   REGULAR LIVE   FACIAL & INTIMATE
1
 Môle B, Gozlan L. – “Benefits of adding lidocaïne to a hyaluronic gel – STYLAGE ® M” – J. Cosm and laser therapy – 2011 Oct – 13(5): 249-254. Post-CE Marking single-blind clinical     TRAININGS      LEADERS      EACH MONTH      WEBINARS        AESTHETICS
study performed on 84 patients comparing Stylage ® M versus Stylage ® M lidocaine. Level of pain experienced by patient during injection and massage measured on a scale from 1 to 10.
B E FO R E                                                                                                                                                 BEFO RE
   A FTE R                                                                                                                                                     AFTER

ST YL A G E ® HYDROMAX: C H E EKS                                                                            STYLAGE ® M: CHEEKS, NASOGENI AN FOLDS

                                                                 © Copyright – Dr Maria Grazia Caputo (IT)

                                                                                                                                                                        © Copyright – Dr Sylvie Poignonec (FR)
                                                                                                             STYLAGE ® L : NOSE
ST YL A G E   ®
                  S P E C I A L L I P S : L I PS                                                             STYLAGE ® X X L : JAWLI NE, CHEEKB ONES, CHI N

                                                                                                                                                                        © Copyright – Dr James Schinazi (FR)
                                                                 © Copyright – Dr Jasmin Taher (UK)

STYLA G E ® S : F O R E H E A D , G LABEL L A, EY E W RINKL ES                                               STYLAGE ® X L : CHI N
                                                                 © Copyright – Dr Natalia Romanowska (PL)

                                                                                                                                                                        © Copyright – Pr Ali Mojallal (FR)
M A D E            I N      F R A N C E

                                                               v i v a c y l a b . c o m

                                                              LABORATOIRES VIVACY
                                                       44, rue Paul Valéry - 75116 Paris, France
                                                               Tel : +33 (0)1 56 90 08 08

                                              Manufacturer LABORATOIRES VIVACY
                             252, rue Douglas Engelbart - Archamps Technopôle - 74160 ARCHAMPS, France
                                                       Tel : +33 (0)4 50 31 71 81

Medical Devices Class III, regulated health products bearing the CE marking (CE 0344) in accordance with Medical Device Regulation. MK461 vB (06.2020) - lemahieudesign
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