Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia

 
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Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
M E M O R I A L              H E R M A N N

                                                          S P R I N G      2 0 21

SURVIVORSHIP

Kristy Martin: Atypical Presentation of Acute
Myeloid Leukemia
On March 5, 2020, Kristy Martin woke
up to find her legs weren’t working cor-
rectly. The 46-year-old mother of four
was scheduled to see her primary care
physician for a follow-up appointment
for back pain that day. “Since I couldn’t
drive, I called an Uber car to take me to
my appointment,” she says. “I didn’t
think it was urgent.”
   When Martin arrived at the offices
of primary care physician Douglas Tsu-
chida, MD, on the campus of Memo-
rial Hermann Memorial City Medical
Center and explained what she was
experiencing, Dr. Tsuchida wheeled
her directly into the hospital’s Emer-
gency Center.                               Pictured, from left to right: Adan Rios, MD; Kristy Martin; Michelle Schulhauser, RN; and Jay-Jinguang Zhu, MD, PhD.
   There, an MRI revealed a large mass
in the region of her lower spine. In        of the most advanced neuroscience                               Describing Martin’s diagnosis, Dr.
the operating room, a team of neuro-        centers in Houston, where where she                          Rios says, “The presence of leukemic
surgeons, led by affiliated UTHealth        began receiving inpatient occupational                       tissue outside the bone marrow oc-
Neurosciences neurosurgeon Spiros           and physical therapy under the care of                       curs in about 3 percent to 9 percent of
Blackburn, MD, associate professor          neuro-oncologist Jay-Jinguang Zhu,                           patients with acute myeloid leukemia.
in the Vivian L. Smith Department of        MD, PhD, professor in the Vivian L.                          It can occur in the skin or in any organ.
Neurosurgery at McGovern Medical            Smith Department of Neurosurgery at                          In her case, it occurred as a very large
School at The University of Texas Health    McGovern Medical School.                                     mass that compressed her spinal cord
Science Center at Houston (UTHealth),          “That was where my story took a                           on the right side from the level of the
removed the tumor (as much as could         turn,” says Martin.                                          thoracic vertebral body eight (T8) down
safely be removed without causing              The pathology laboratory results indi-                    to the lumbar vertebral body L1 in the
further damage to the spinal cord). In      cated the tumor was a myeloid sarcoma,                       lumbo-sacral region, extending into the
addition, the team performed a laminec-     acute leukemia outside the bone marrow.                      anterior portion of her abdomen.”
tomy, a surgical procedure to ease the      Given the diagnosis was not a neurologi-                        Dr. Rios, who Martin describes as a
pressure on her spinal cord and nerve       cal tumor but rather an unusual form                                    Atypical Presentation continues on page 2
roots that was causing her pain and her     of acute leukemia, Dr. Zhu brought in
inability to walk. Tumor samples were       Adan Rios, MD, professor in the Divi-
sent to a pathology lab for analysis.       sion of Oncology at McGovern Medical
   Martin was transferred to the            School, whose special interests include
Neuroscience Center at Memorial             hematological malignancies (leukemia,
Hermann Southwest Hospital, one             lymphoma and multiple myeloma).
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
Atypical Presentation continued from page 1            see my kids and the rest of my family,”          IN THIS ISSUE
“collaborative genius,” consulted with                 she says. “But the nurses and chaplains          SURVIVORSHIP 1-6
colleagues across multiple disciplines                 really helped lift my spirits. They helped       	 Kristy Martin: Atypical Presentation of
to create a care plan for Martin. In                   me video chat with my family and even              Acute Myeloid Leukemia
tandem, plans were made to initiate                    shared their own stories with me.”                 Young Dad Beats Colon Cancer,
dose-intensive inpatient chemotherapy                     Martin was discharged from the hospital         Welcomes Second Child
at Memorial Hermann-Texas Medical                      on June 5, 92 days after arriving via Uber         Drama Therapy: Empowering Cancer
Center and to initiate a rehabilitation                car at her primary care physician’s office         Thrivers to Grow and Heal
program at TIRR Memorial Hermann in                    for her follow-up visit. Throughout her            Exercise May Increase Cancer Survival
the Texas Medical Center.                              journey, she was cared for by over a dozen       A NOTE FROM LEADERSHIP 7
   “In injuries of the spinal cord, the                UTHealth and Memorial Hermann affili-            EXCELLENCE IN CANCER CARE 8-12
immediate restoration of function and                  ated specialists—emergency physicians,             Natalie Davis: Surprise Colon Cancer
rehabilitation are essential for recovery              surgeons, neurologists, hematologists,             Diagnosis
of these patients,” says Dr. Rios. “Even               oncologists, radiologists and neuroreha-           What You Need to Know About
when she was at TIRR, she was getting                  bilitation specialists—plus a host of physical     Breast Cancer: Experts Weigh In
her chemo treatment. There aren’t                      and occupational therapists, nurses, social        Breast Cancer Prevention and
                                                                                                          Survivorship: A Family’s Story
many institutions where this type of                   workers, chaplains, home health providers
                                                                                                          Ahmed Samara: Back on the Road
dose-intensive chemotherapy and multi-                 and others, who worked in concert to
                                                                                                          After Metastatic Melanoma
disciplinary team are available.”                      ensure the best possible outcome.
                                                                                                          USPSTF Updates Lung Cancer
   Martin’s care plan would eventually                    Martin has regained some use of her             Screening Recommendations
include radiotherapy, provided by radia-               legs, although she’s mostly wheelchair
                                                                                                        ADVANCES IN CANCER TREATMENT 13-16
tion oncologist Mark Amsbaugh, MD,                     dependent. But that’s not holding her
                                                                                                          Oncologic Emergencies: Improving Patient
assistant professor of neurosurgery at                 back. She recently relearned to drive a            Care Through Enhanced Collaboration
McGovern Medical School and medical                    car using hand controls. (“It’s so cool to         Dale Thornton: Thriving After Robotic
director of radiation oncology at Memo-                be on the road again!”) A self-described           Rectal Cancer Surgery
rial Herman-TMC, and oral chemother-                   “good home chef,” she’s relearning to              Transoral Robotic Surgery Speeds
apy maintenance treatment, prescribed                  chop at a different angle.                         Throat Cancer Patient Recovery
by Dr. Rios to prevent recurrence.                        “My whole life changed. Every-                  Karen Echols: The Warning Signs Were There
   As if Martin’s medical challenges                   thing changed,” she says. “But it has            ON THE PODIUM 16-17
weren’t enough, just as she was diag-                  been such a positive journey. It made              Memorial Hermann Oncology Certified
nosed, the COVID-19 pandemic hit, and                  me realize what’s important and                    Nursing (OCN) Review a (Virtual) Success
hospital visitation restrictions were put              what’s not. Everyone worked together.              Reducing Preventable Emergency Center
in place. “It was hard because I couldn’t              It all worked out.” g                              Visits by Chemotherapy Patients
                                                                                                          Changing the Way We Work—
                                                                                                          With Surprisingly Positive Results
BEFORE                                                 AFTER
                                                                                                        RESEARCH 18-27
                                                                                                          Ongoing Clinical Trials
                                                                                                        VOLUNTEER SPOTLIGHT 28
                                                                                                          Peyton Welch Tells His Story and Helps
                                                                                                          Others Tell Theirs
                                                                                                        COMMUNITY OUTREACH 29-33
                                                                                                          Memorial Hermann Delivers ‘A Shot of Hope’
                                                                                                          Preparing for the Inevitable:
                                                                                                          Advance Care Planning
                                                                                                          Return to Wellness: Prioritizing Cancer
                                                                                                          Screening During a Pandemic
                                                                                                          Memorial Hermann Distributes Colon
                                                                                                          Cancer Screening Kits
                                                                                                          In the Pink Distributes $450,000 to Local
                                                                                                          Organizations Fighting Cancer
PET CT reveals a very large myelosarcoma mass          PET CT shows complete resolution of the mass
compressing the patient’s spinal cord on the her       following treatment.
                                                                                                        MEMORIAL HERMANN WELCOMES 34
right side, from the level of the thoracic vertebral                                                    ABOUT MEMORIAL HERMANN 35
body eight (T8) down to the lumbar vertebral body
L1 in the lumbo-sacral region, extending into the                                                       CANCER CARE
anterior portion of her abdomen.

2   MEMORIAL HERMANN CANCER JOURNAL
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
Young Dad Beats Colon Cancer, Welcomes Second Child
In 2017, Daniel Begnaud’s world as                                                               more important than ever.
he knew it came crashing down when                                                                 In July 2018, his prayers were
he was diagnosed with stage IV colon                                                             answered when scans showed the
cancer at the age of 30. A father of a                                                           chemo had worked and he was a
1-year-old son, he was initially told                                                            candidate for surgery. His 13-hour
that it was unlikely he would ever                                                               surgery included a colon resection,
have more children. On top of a                                                                  gallbladder removal, liver ablation
cancer diagnosis, it was a hard pill to                                                          and a peritoneum and lymph node
swallow. From the moment his son,                                                                removal. In October 2018, he was
Luke, was born, he knew he wanted                                                                given a clean bill of health. His scans
more children. He never dreamed it                                                               showed no evidence of disease.
might not be an option.                                                                            Despite all of the bad that comes
   “Up until I was told I had cancer, my                                                         with a cancer diagnosis, he says the sil-
wife and I were living the dream,” says                                                          ver lining is that he can be an advocate
Begnaud. “We were checking all the                                                               for his children. “It was a numbing
boxes—career success, buying our first                                                           feeling to learn that the cancerous tu-
house, celebrating five years of mar-                                                            mor had been growing in my body for
riage, and Luke turned 1. There were so        family when she told him he would be on       about 10 years, meaning it started when I
many great things happening in our lives,      chemo for the rest of his life, would never   was 20. I now know that my children will
but in hindsight, I wasn’t feeling my best.”   be able to have more children and had a       need to undergo screening around that
   While Begnaud didn’t feel sick, he felt     life expectancy of less than 2 years. “But    time because of my diagnosis. At least
sluggish, which he chalked up to being         Daniel proved me wrong. And in this case,     now I have the tools and knowledge to be
a tired parent. But after finding blood in     I wanted to be proven wrong,” she says.       proactive and potentially prevent colon
his stool, Begnaud had a colonoscopy,          “He is a true testimony to his faith and      cancer for them.”
which revealed a large tumor in his co-        believing his cancer would be cured.”            Although Begnaud was diagnosed
lon. Later, scans showed that the cancer          Dr. Rowe says it is unusual to see         at such a young age, he doesn’t have a
had spread outside of the colon to the         people in their early 30s with advanced       family history of colon cancer. “Many
liver, abdomen and lymph nodes.                colon cancer, but more and more young         people think if they don’t have a family
   Medical oncologist Julie Rowe,              patients are being diagnosed. “Cancer         history of cancer they don’t need to
MD, assistant professor at McGovern            research is focusing on trying to un-         worry about screening,” he says. “But
Medical School, who sees patients at           derstand why this is happening and on         I am living proof that’s not true. If you
Memorial Hermann Cancer Center-                finding ways to improve screening for         have any inkling that something isn’t
Texas Medical Center and Memorial              cancer,” she says. “It’s also why the rec-    right, get screened. It could add years to
Hermann Cancer Center-Northeast,               ommended screening age was recently           your life.”
says that while screening is definitely        changed from 50 to 45.”                          Thankfully, it looks like that is the
the key to catching cancer earlier, in            “I remember when I went in for             case for Begnaud. In July 2019, he rang
Begnaud’s case, he did not meet the            my colonoscopy, my biggest concern            the bell that signified the end of his
standard screening criteria because of         was where I was going to eat pancakes         treatment. In March 2020, his scan
his young age.                                 afterward,” recalls Begnaud. “I never         came back clear. He says the only thing
   “I think, in general, a person needs        considered I would be starting my first       that topped that was the birth of his
to ‘know’ his or her body well and watch       of 21 rounds of chemo.”                       daughter, Ava, one week later.
for signs that are not normal, such as            The plan was to shrink the tumor              Begnaud’s road to recovery has
unintentional weight loss or changes           enough to do surgery, but before this         included some detours. “I had a recur-
in bowels or urine,” says Dr. Rowe. “I         happened there was a hiccup in his            rence in July 2020. In August, I had a
encourage patients to keep track of the        plan when he experienced severe               small mass removed laparoscopically
things they feel are unusual and not           pain. Doctors discovered his colon            followed by 11 more rounds of mainte-
ignore them. Ignoring these symptoms           had stopped working, and they had             nance chemo,” he says.
can lead to more advanced cancer.”             to put in a stent. A youth minister              His recent scans were clear, so his
   Dr. Rowe remembers the heartbreak-          at Central Baptist Church in Buna,            next round of chemo should be his last.
ing conversation with Begnaud and his          Texas, Begnaud knew prayer was now            And he will ring the bell again. g

3   MEMORIAL HERMANN CANCER JOURNAL                                                                                       S P R I N G 2 0 21   3
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
Drama Therapy:
Empowering Cancer Thrivers to Grow and Heal
                                                                                                                   express feelings or achieve catharsis.
                                                                                                                   Through drama, the depth and breadth
                                                                                                                   of inner experience can be actively ex-
                                                                                                                   plored, and interpersonal relationship
                                                                                                                   skills can be enhanced.
                                                                                                                   Cancer Journal: From which therapeutic
                                                                                                                   approaches does drama therapy draw?
                                                                                                                   Welch: In my drama therapy work, I
                                                                                                                   often combine select elements from
                                                                                                                   existential therapy, which focuses on
                                                                                                                   self-awareness and freedom; person-
                                                                                                                   centered therapy, a non-directive,
                                                                                                                   empathic approach that empowers and
                                                                                                                   motivates the client in the therapeutic
                                                                                                                   process; and Gestalt therapy, which
                                                                                                                   focuses on the individual’s experience
                                                                                                                   in the present moment. However, each
                                                                                                                   approach is based on a client’s specific
                                                                                                                   needs and objectives.
                                                                                                                   Cancer Journal: What theater tech-
                                                                                                                   niques does drama therapy involve?
Rebecca Clarke, a metastatic cervical cancer “thriver,” shares her story via a tableau during a drama therapy      Welch: Drama therapy employs a wide
session at Canopy. "I call it 'Solace' because it depicts the only comfort I can give my elderly mother, who has
lost two sons to cancer and feels helpless in coping with my cancer," she says.                                    range of drama tools and techniques.
                                                                                                                   Common approaches include improvi-
Registered Drama Therapist Peyton                          “Drama therapy is a wonderful addition                  sation, the use of masks, performance,
Welch understands the physical, men-                       to our line-up, which includes a wide va-               storytelling, role playing, puppetry and
tal and emotional toll that debilitating                   riety of programs and services addressing               playback theater.
illness, including cancer, can take. In                    the emotional, physical and social needs
                                                                                                                   Cancer Journal: What does a typical
October 2019, the 40-year-old Arkan-                       of those touched by cancer.”
                                                                                                                   drama therapy session look like?
sas native turned Houston transplant                       Cancer Journal: What is drama therapy?
was diagnosed with stage II/III brain                                                                              Welch: Each session begins with a
                                                           Welch: Drama therapy is an expressive                   check-in in which participants share
cancer for which he underwent brain
                                                           and action-oriented therapy that fo-                    how they are currently feeling. This
surgery followed by radiation therapy.
                                                           cuses on the “here and now.” It actively                provides important information to the
   “The diagnosis hit me like a ton of
                                                           intertwines psychology with theater,                    drama therapist about how to lead the
bricks,” he recalls. “I remember think-
                                                           allowing participants to see and under-                 group that day, what issues are ready
ing, I will never be the same again.”
                                                           stand their real-life struggles in a new                to be worked on and what resistances
   Fortunately, years before his cancer
                                                           way, making discoveries through their                   will need to be worked past to get the
diagnosis, Welch, who suffers from
                                                           own experiences and experimentation.                    group to function openly and smoothly.
epilepsy, discovered—and ultimately
pursued a career in—a novel yet power-                     Cancer Journal: Who might benefit from                  Next, a warm-up gets everyone fo-
ful form of therapy: drama therapy.                        drama therapy?                                          cused on each other and on being in
Now, he shares this beneficial approach                    Welch: Just about anyone can benefit—                   the “here and now.” A warm-up also
with other cancer thrivers and their                       individuals, families and communities                   prepares muscles that may be used in
families from all over Greater Houston                     struggling with change, loss or other                   activities later in the session and pre-
at Canopy at Memorial Hermann The                          challenges. This approach can provide                   pares imaginations so everyone is ready
Woodlands Medical Center.                                  the context for participants to tell their              to work together creatively and safely.
   Amanda Poole, Canopy manager, says,                     stories, set goals and solve problems,                               Drama Therapy continued on page 5

4   MEMORIAL HERMANN CANCER JOURNAL
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
Drama Therapy continued from page 4                   Then each person will write down one         in drama therapy from Kansas State
Each session usually includes at least one            obstacle they are currently facing. We       University in 2017 and was registered
major drama therapy activity in which the             put everyone’s obstacles on the chairs       through the NADTA in 2019.
group participates, then discusses. Par-              and go through the course again. There
                                                                                                   Cancer Journal: What do you hope
ticipants who have assumed a role need to             is no right or wrong way to go about it.
                                                                                                   participants will take away from their
“de-role” afterward in order to reconnect             I tell participants, I want you to be you.
                                                                                                   drama therapy experience?
with themselves. The group ends with a                What is your ideal way to overcome
closure activity, such as a game, ritual,             these obstacles? Then we process,            Welch: My personal mission statement
review of the session or song.                        which sparks ideas. We always close on       is “Learning to accept life’s challenges
                                                      a positive note.                             and values by embracing hope, creativi-
Cancer Journal: Can you provide an                                                                 ty and personal worth!” I tell everyone,
example of a “major drama therapy                     Cancer Journal: How does one become a        your story matters. Share your story
activity”?                                            drama therapist?                             and know there is always hope.
Welch: We often use metaphors and                     Welch: To become Registered Drama
symbolism. For instance, in one activ-                Therapist (RDT), you must earn a             To learn more about Welch and his
ity, participants navigate an obstacle                master’s or doctoral degree in drama         cancer journey, see “Peyton Welch
course made up of chairs, each labeled                therapy from a program accredited by         Tells His Story and Helps Others Tell
with a word or phrase representing an                 the North American Drama Therapy             Theirs” on page 28. g
obstacle, such as “mud,” “monkey                      Association (NADTA) or a master’s or
bars” or “ice.” Each person navigates                 doctoral degree in theater or a men-         To register for a drama therapy session at
the course, acting out how he or she                  tal health profession with additional        Canopy, call 713.897.5939. To find out more
would overcome each obstacle. It’s                    in-depth training in drama therapy           about the services and programs offered at
fun to see how different people face                  through NADTA’s alternative training         Canopy, visit memorialhermann.org.
and deal with different challenges.                   program. I received my master’s degree

Exercise May Increase Cancer Survival
It’s common knowledge that exercise is
important for good health. In addition,
studies have shown that regular exer-
cise can lower cancer risk and improve
a person’s quality of life during cancer
treatment. But did you know that regular
exercise may also help decrease the risk of
cancer recurrence and improve survival?

Reducing Cancer Risk
Physical activity may lower risk of cancer
by helping control weight, regulating
hormones or insulin and strengthening
the immune system.
   A study from the researchers at the
American Cancer Society and the Na-
tional Cancer Institute, published in the
May 16, 2016, issue of JAMA Internal
Medicine, linked physical activity with a
lower risk of 13 specific types of cancer,
including colon, breast, endometrial,
esophageal, liver, stomach, kidney, head
and neck, rectum, bladder and lung
cancers, as well as myeloid leukemia and
multiple myeloma.
                      Excercise continues on page 6

5   MEMORIAL HERMANN CANCER JOURNAL                                                                                            S P R I N G 2 0 21   5
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
Excercise continued from page 5              swell Park Cancer Center and National       Not One-Size-Fits-All
Boosting Quality of Life During Cancer       Cancer Institute, concluded that exer-      Sisk says that while cancer patients and
Treatment                                    cise after a cancer diagnosis—even once     survivors can certainly benefit from
Patients undergoing cancer treat-            or twice a week, and even in patients       regular physical activity, there’s no
ment may also benefit from being as          who had not exercised prior to their        one-size-fits-all answer. “Each person’s
physically active as possible during         cancer diagnosis—improved survival.         exercise program should be based on
cancer treatment. Among the benefits,           The study found that “habitually ac-     his or her condition and abilities,”
exercise can help improve balance,           tive” patients had the biggest survival     she says. “While several studies have
strengthen muscles, improve cardiac          advantage over their sedentary coun-        shown the benefits of exercise for can-
health, reduce anxiety and depression,       terparts. Those who exercised three to      cer patients, overdoing it can put cer-
improve self-esteem and lessen nausea        four times a week before and after their    tain cancer patients, including those
and fatigue.                                 cancer diagnosis reduced their overall      who are seriously ill or have comorbidi-
   “One of the most common com-              mortality risk by 39 percent and their      ties, at additional health risk,” she says.
plaints I hear from patients undergoing      cancer-specific mortality by 36 percent.    “Patients should speak to their doctor
cancer treatment is about the fatigue,”      Patients who engaged in exercise 1 to 2     before starting any type of exercise.”
says Memorial Hermann Oncology               days a week before and after their cancer      Sisk says physical activity doesn’t have
Nurse Navigator Angela Sisk, RN. “I          diagnosis experienced a 32 percent          to be strenuous to be effective. “Emerg-
try to bring it up even before they do.      reduction in both all-cause mortality       ing research shows yoga use by cancer
I tell them, ‘I know it seems counter-       and cancer-specific mortality.              patients can improve overall wellbeing
intuitive to get up and exercise when           But the study also found that those      in addition to relieving stress, anxiety
you’re so tired, but if you can get up and   who had been sedentary in the decade        and some of the negative side effects
exercise a bit, you’ll feel better.’”        prior to their diagnosis experienced a      related to cancer treatment.”
                                             28 percent drop in all-cause and cancer-       A Certified YogaNurse®, Sisk taught
Improving Cancer Survival                    specific mortality when they exercised      yoga classes at Memorial Hermann
Now, researchers are finding that regu-      just one to two times a week during the     Greater Heights Hospital prior to the
lar physical activity may also reduce a      year following their diagnosis.             pandemic and hopes to resume teach-
cancer survivor’s risk of cancer recur-         And these survival benefits were         ing when it’s safe to do so. “I have been
rence and improve survival.                  found to occur regardless of the pa-        an oncology nurse for 25 years and
  A 2018 study of the cancer survival        tient’s sex, age, weight, smoking status    have been practicing yoga for almost
benefits of exercise, funded by the Ro-      or cancer state.                            as long,” she says. “I’ve found that re-
                                                                                         storative, therapeutic yoga offers a safe,
                                                                                         gentle practice that is especially helpful
                                                                                         for patients with cancer.”
                                                                                            Yoga classes are also offered at Can-
                                                                                         opy at Memorial Hermann The Wood-
                                                                                         lands Medical Center. “Canopy offers
                                                                                         a wide variety of free programs and
                                                                                         services to address the emotional, phys-
                                                                                         ical and social needs of those touched
                                                                                         by cancer,” says Amanda Poole, man-
                                                                                         ager of Canopy. “In addition to offering
                                                                                         yoga classes twice a week, we also offer
                                                                                         Pilates, barre and tai chi classes. Many
                                                                                         of our classes are taught both online
                                                                                         and in person. In-person class sizes are
                                                                                         limited to allow for social distancing.” g
                                                                                         For a complete list of Canopy offerings,
                                                                                         call 713.897.5939.

                                                                                                    ANGELA SISK, RN
                                                                                                    Oncology Nurse Navigator
                                                                                                    Memorial Hermann Greater Heights Hospital

6   MEMORIAL HERMANN CANCER JOURNAL
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
A NOTE FROM LEADERSHIP

                      I want to urge       mission on Cancer accredited centers      walking into our facilities to receive
                      everyone who         to safely provide for all your cancer     care.
                      is reading this      screening and cancer care needs.            At Memorial Hermann, I feel privi-
                      message today          Detecting cancer early is the           leged to work alongside some of the
                      to return to         primary goal of cancer screening          best and brightest surgical, medical
                      wellness care,       because finding cancer earlier can        and radiation oncologists our city has
                      including cancer     mean a better outcome for you. Talk       to offer. Our multidisciplinary teams
                      screening. Have      to your healthcare provider today         work together to create personalized
                      you had your         about scheduling your mammogram,          treatment plans that give every
                      mammogram in         cervical screening, prostate cancer       patient the best chance at survival.
the last 12 months? Have you spoken        screening, colon cancer screening         Even with the challenges we have
to your provider about a colon cancer      and lung cancer screening. Memorial       faced recently, we will continue
screening test? Are you ready to have      Hermann is ready to help you get your     to provide every patient with the
a low-dose CT lung cancer screening        in-person screenings done safely and      personalized care and support they
exam? Many of you have delayed can-        quickly.                                  deserve. At Memorial Hermann,
cer screenings during the coronavirus        As we continue to navigate the pan-     no one faces cancer alone.
pandemic. The American College of          demic, it is my hope that the commu-
Surgeons Commission on Cancer and          nity understands the safety processes     Sandra Miller, MHSM, RN, NE-BC
Memorial Hermann Cancer Centers            we have put into place to be able to      Vice President
urge you to you to return to regular       treat everyone safely. We are com-        Memorial Hermann Oncology
wellness care and cancer screening.        mitted to doing everything we can to      Service Line
Memorial Hermann has eight Com-            make sure people feel comfortable

                     Every year            outlined by national health leaders.      medical team takes very seriously.
                     brings change.        It’s understandable that some may         It is my hope that the public sees our
                     It’s a part of life   feel hesitant to get the vaccine. After   commitment and places trust in us
                     for all of us, but    all, this is new to all of us. However,   so we can continue to make strides in
                     no one could          the important thing to remember is        beating COVID-19. Be the change.
                     have predicted        that the vaccine’s efficacy is backed     Do it for yourself and for your loved
                     how drastically       by science and has been reviewed          ones. I already have.
                     our world has         by panels of experts in the field.
                     changed since         These mRNA vaccines, which deliver        In good health,
                     the pandemic          genetic material to create proteins,
                     started. From         have been studied for more than a         Ron J. Karni, MD
the way we view social gatherings          decade and have shown to be very          Chair, Oncology CPC Subcommittee
to wearing masks as part of our daily      effective in preventing COVID-19          Memorial Hermann Physician
routines, the pandemic has changed         infection. Doing your part in getting     Network
our mindsets and the way we practice       vaccinated is the first step in help-
medicine.                                  ing to achieve herd immunity to help
  The one thing that should never          slow the spread of the coronavirus.
change is our commitment to our               As a vaccine hub for the state of
own personal health. Part of this          Texas, Memorial Hermann has a
commitment is getting the COVID-19         responsibility to take care of the com-
vaccine when it is available to you, as    munity, a responsibility our entire

7    MEMORIAL HERMANN CANCER JOURNAL                                                                          S P R I N G 2 0 21   7
Kristy Martin: Atypical Presentation of Acute Myeloid Leukemia
EXCELLENCE IN CANCER CARE

Natalie Davis: Surprise Colon Cancer Diagnosis
“Cancer” was not what Natalie Davis             “By using the robot, we can spare the
was expecting to hear. After all, she        patient an open surgery,” says Dr. Gaj-
was 50 years old. She had no history of      jar. “A minimally invasive surgery yields
colon cancer in her family. The colo-        smaller incisions, less pain, a shorter
noscopy—her first—was routine. And           hospital stay, less risk of infection and a
she felt perfectly fine.                     faster recovery and return to work.”
   “Life has a sense of humor,” says            “Everything went really well,” says
Davis. “Up until that day, my only ex-       Davis, who describes her surgery as
posure to colorectal cancer was writing      “uneventful.” She was moving around
about it for a paper in grad school.”        that night and walking the next day.
   Yet in October 2019, Davis found             Because her cancer was caught at
herself in the office of Memorial Her-       an early stage, Davis did not require
mann Medical Group gastroenterolo-           radiation or chemotherapy. “Early
gist Shaheryar Siddiqui, MD, who had         detection through cancer screening
performed her colonoscopy at Memo-           is so important,” says Dr. Gajjar. “So
rial Hermann Southwest Hospital a            many younger people are getting
couple days earler.                          diagnosed with colon cancer these               While her diagnosis came as a
   “I explained to Natalie that dur-         days. Everyone thinks 50 is the age at        surprise, Davis says about a month
ing the colonoscopy, I found a lesion        which you should get your first colo-         before her diagnosis, she decided to
in her sigmoid colon, which was too          noscopy. But recently, the American           adopt a more plant-based diet and lost
large to be removed through a colonos-       Cancer Society began recommending             her lifelong “sweet tooth.” “I still eat
copy,” says Dr. Siddiqui. “I tattooed        that the general public should start          meat on occasion, but I have added
the area (marked the area of the lesion      getting colonoscopies at the age of           more leafy greens and legumes to my
on the outside of the colon so that a        45*, earlier if a person is experienc-        diet,” she says. “And I recently re-
surgeon could locate it, if surgery were     ing symptoms or has a family history          sumed my yoga practice. I feel better
required) and sent a sample to the pa-       of colon cancer.”                             than I did before the cancer.” g
thology laboratory to be biopsied. The          Davis wholeheartedly concurs. “I’ve
results indicated she had colon cancer.      been telling people, even if you have no      *Due to recent changes in screening
Fortunately, the cancer had not spread       symptoms, get screened. By the time           recommendations, please consult your
outside the colon, including to the          you have symptoms, your cancer may            insurance provider to confirm coverage
lymph nodes.”                                have already advanced.”                       if you are under age 50.
   Dr. Siddiqui referred Davis to colon
and rectal surgeon Aakash Gajjar, MD,
for a surgical consult. Dr. Gajjar saw her   What You Need to Know About
that same day.
   “Dr. Gajjar explained my situation to     Breast Cancer: Experts Weigh In
me, and we had a conversation about
how things could go,” recalls Davis.
“I could tell from the conversation he       One in eight women will be diagnosed          breast cancer and breast cancer preven-
knew what he was doing. I felt comfort-      with breast cancer in her lifetime, making    tion, in October 2020, three members
able I would be in good hands.”              breast cancer the second most common          of the Memorial Hermann affiliated
   In December 2019, Dr. Gajjar per-         cause of death from cancer in women in        cancer team participated in an on-
formed a robotic sigmoid colectomy, a        the U.S. after lung cancer. Early detection   line breast cancer awareness webinar
minimally invasive surgical procedure        saves lives. When breast cancer is caught     hosted by the Houston International
to remove the diseased part of Davis’        early, before it has spread outside the       Women’s Ministry and the Houston
colon. The procedure, which took a           breast, the 5-year survival rate of women     International Seventh Day Adventist
few hours, was performed at Memorial         with the disease is 98 percent.               Church.
Hermann Sugar Land Hospital.                   In an effort to educate women about                Breast Cancer Experts continued on page 9

8    MEMORIAL HERMANN CANCER JOURNAL
Breast Cancer Experts continued from page 8     for years. She even had a biopsy when      carbohydrates, sugar and red meat
Here, we share highlights from the              she was 42, but it was negative for        with a diet rich in fresh fruits and veg-
2-hour webinar.                                 cancer. She has been worried about         etables, whole grains (which are high
                                                her breast health for years, since it      in fiber) and soy-based protein, beans
Who is considered at high risk for              seemed every other year, she was           and lean animal protein, such as skin-
breast cancer?                                  called back for a 6-month follow-up        less chicken and fish. Dr. Gonzalez
According to the American Cancer                screening.                                 recommends a stepped approach,
Society, the average risk for breast               The patient started her period at       giving up one bad thing a week and
cancer is 13 percent and increases with         age 11. She is 5'2" and weighs 168         adding one healthful one.
age until age 80. The average age of            pounds. She had kids after graduate          Not only can a healthful diet help
diagnosis is 62.                                school, her first at age 32. She is        stave off cancer and other serious
A woman is considered to be at higher-          not menopausal. She has been taking        health problems, including heart
than-average risk for breast cancer if she:     the same contraception (progester-         disease and diabetes, but eating
• Has been told that her breast tissue is       one and estrogen) for years. Her aunt      healthfully can also increase cancer
  very dense                                    on her father’s side of the family had     survivability and help prevent cancer
• Began puberty before age 12                   breast cancer.                             recurrence. Lowering alcohol intake
• Began menopause after age 55                     Based on her risk profile, her          to fewer than six glasses of wine a
• Underwent hormone replacement                 lifetime risk for developing breast        week will also decrease a woman’s
  therapy after menopause                       cancer is between 22.7 percent and         risk of breast cancer.
• Has a personal history of breast biopsy       25.7 percent, significantly higher
• Has a family history of breast or             than the average of 13 percent.            What are the stages of cancer, and what
  ovarian cancer                                Therefore, she qualifies for yearly        do they mean to patients?
• Has above normal body mass index              breast mammograms, yearly breast           There is a spectrum of cancer diagnoses
  (BMI) after menopause                         MRIs and risk-reducing medications.        from stages 0 to IV:
                                                                                           • Stage 0 – Abnormal cells are present
African American women are more               What is genetic testing?                       but have not spread outside the
likely to:                                    As Drs. Jones and Gonzalez explained,          breast.
• Be diagnosed with cancer before             there is a hereditary link for breast and
   age 40                                     other forms of cancer. There are ways        • Stages I, II and III – Cancer is present.
• Be diagnosed with breast cancer at a        to test a person’s DNA, their genes, to        The higher the number, the larger
   later stage                                determine if he or she is more predis-         the cancer tumor and the more it has
• Have a more aggressive breast cancer        posed to cancer.                               spread to nearby tissues.
• Die from their breast cancer                                                             • Stage IV – The cancer has spread to
                                              What is the difference between a screening     distant parts of the body.
What is a personalized breast cancer          mammogram and a diagnostic mammogram?
                                              Drs. Gonzalez and Jones recom-               Dr. Jones said that if breast cancer has
risk assessment?                                                                           spread to lymph nodes in the armpit,
Dr. Jones explained that each woman’s         mend annual screening mammo-
                                              grams starting at age 40. If, during a       it is still a curable disease but with a
risk profile for breast cancer is unique                                                   higher risk of recurrence and needs
and is based on the risk factors outlined     screening mammogram, a potential
                                              irregularity is noted, the patient may       to be treated more aggressively. She
above. When Dr. Jones first sees a                                                         emphasized that screening mammo-
patient, she creates a personalized risk      be called back for diagnostic mammo-
                                              gram, to gain additional views of the        grams can help prevent the spread,
assessment for the patient on which she                                                    reiterating that the 5-year survival
bases a personalized treatment plan.          breast. Both physicians emphasized
                                              that getting a call-back does not nec-       rate of patients with stage I and II
In the webinar, she offered the follow-       essarily mean there is a cancer.             breast cancers is 98 percent, adding
ing example:                                                                               that if a woman doesn’t get annual
  The patient is a 45-year-old woman.                                                      mammograms, she puts herself at
                                              What can a woman do to reduce her risk of
  She has been getting annual mam-                                                         risk of getting a later-stage disease.
                                              breast cancer?
  mograms since age 40 because                                                             Dr. Gonzalez added that if breast
                                              While some risk factors, such as
  when she was in her 30s, she had                                                         cancer spreads to organs and bones—
                                              genetics, cannot be overcome, there
  lumpy breasts that her primary                                                           meaning it is stage IV—it can be
                                              are still actions a woman can take to
  care physician frequently imaged                                                         treated but not cured. But treatment
                                              reduce her risk. If she is overweight,
  with an ultrasound. The patient has                                                      can help prolong life.
                                              she should evaluate her diet, replac-
  heard her breasts are “very dense”          ing fast food, packaged foods, starches,           Breast Cancer Experts continued on page 10

9   MEMORIAL HERMANN CANCER JOURNAL                                                                                       S P R I N G 2 0 21   9
Breast Cancer Experts continued from page 9   To schedule an appointment or to refer a
                                                                                                                  JESSICA JONES, MD
                                              patient to the Memorial Hermann Breast                              Medical Oncologist
What is the role of a caregiver to a breast   Cancer Prevention Program, call the UT                              Assistant Professor, McGovern Medical School

cancer patient?                               Physicians Multispecialty–Bayshore clinic                           Leader, Memorial Hermann Breast Cancer
                                                                                                                  Prevention Program
Ruiz, whose mother was diagnosed              at 713.486.6325.
with breast cancer 3 years ago, says a                   ANELIESE GONZALEZ, MD
caregiver plays a very important role                    Medical Oncologist
                                                                                                                  SHIRLEY RUIZ, RN
                                                         Associate Professor and Director, Hematology
in the physical and emotional wellbe-                    Oncology Division, McGovern Medical School
                                                                                                                  Oncology Nurse Navigator,
                                                                                                                  Memorial Hermann-Texas Medical Center
ing of a cancer patient. Her advice? Be                  Medical Director, Memorial Hermann Cancer
                                                         Center-Texas Medical Center
a support system for them by provid-
ing transportation to appointments.
When accompanying them to their
appointments, be a second set of ears         Breast Cancer Prevention and
for them. But as important, simply
be there for them. Listen and provide         Survivorship: A Family’s Story
emotional support.
                                              Claudia Osorio, 32, and her sister, Ana                   was rough. “Mom was on ‘red devil’
What is the role of the Oncology Nurse        Osorio, 33, are hoping to keep the                        (doxorubicin), which caused her to lose
Navigator?                                    wolf at the door—breast cancer—at bay.                    all of her hair and made her nails turn
Ruiz and her fellow Memorial Her-             Their mother, Rosa Osorio, 55, was                        purple. She literally couldn’t speak for
mann Oncology Nurse Navigators                diagnosed with breast cancer in 2019.                     three days after her treatments. Dad had
help cancer patients find support,            Their sister, Elizabeth Osorio, 36, was                   to help her go to the restroom.”
such as online support groups, men-           diagnosed a year later.                                      As soon as Rosa’s insurance policy
tors and financial resources. They               Fortunately, all four women are patients               took effect January 1, 2020, the sisters
help patients find transportation to          at a new UT Physicians clinic dedicated                   sought treatment for their mom in
medical appointments. Assist pa-              to improving breast health, preventing                    Houston. “We did a ton of research to
tients with their mental wellness. And        breast cancer in high-risk patients and                   find her the best care,” says Claudia.
provide information on resources for          providing compassionate, quality cancer                   “We made an appointment with Dr.
survivors, such as Canopy at Memori-          care. Claudia and Ana are also benefitting                Jones, and it was amazing. Mom’s doing
al Hermann The Woodlands Medical              from a new Memorial Hermann Breast                        great. She’s glowing with good health.”
Center, open to cancer survivors and          Cancer Prevention Program.                                   “Rosa’s daughters went above and
their families and caregivers across             The clinic and Program are led by                      beyond to make sure that they were
the Greater Houston area.                     medical oncologist Jessica Jones, MD,                     getting the appropriate care for their
                                              assistant professor of oncology at                        mother,” says Dr. Jones.
What has been the effect of COVID-19 on       McGovern Medical School, who is                              Now that Rosa has completed her
breast cancer?                                affiliated with Memorial Hermann-                         therapy, she sees Dr. Jones every 3
Unfortunately, the COVID-19 pandemic          Texas Medical Center and is involved                      months.
has resulted in a sharp decline in breast     in breast cancer research.
                                                                                                        Elizabeth: Stage II Breast Cancer
cancer screenings. According to a study       Rosa: Stage II Breast Cancer                              Having watched her mother go through
published in the November 2020 issue          Rosa learned she had breast cancer                        cancer, Elizabeth insisted she and her
of JCO Clinical Cancer Informatics,           while accompanying her daughter                           sisters get mammograms. Elizabeth
screenings for breast cancer were down        Claudia to a doctor’s appointment                         got hers at The Rose. Abnormalities
85 percent in April 2020 from April 2019.     in Mexico. “The minute the doctor                         seen in the mammogram necessitated
The researchers concluded that “the           touched mom’s breast, his eyes opened                     a biopsy, which revealed she had cancer
pandemic has resulted in decreases and        wide, and he told her she needed to get                   in both breasts.
delays in identifying new cancers and         it biopsied right away,” recalls Claudia.                    “Fortunately, she had already met
delivery of treatment. These problems,        “She had been feeling lumps before,                       Dr. Jones,” says Claudia.
if unmitigated, will increase cancer mor-     but she just waited and waited.”                             “With Elizabeth, we hit the ground
bidity and mortality for years to come.”         In July 2019, a biopsy revealed Rosa                   running and personalized her treat-
   Drs. Jones and Gonzalez urge women         had breast cancer. In August, she un-                     ment and care,” says Dr. Jones. “To
not to delay screenings, again reiterat-      derwent surgery to have her right breast                  ensure the best surgical outcome, we
ing that early detection through screen-      removed, followed by chemotherapy,                        initiated chemotherapy up front. Since
ing saves lives. g                            both in Mexico. Claudia says the chemo                                A Family's Story continued on page 11

10   MEMORIAL HERMANN CANCER JOURNAL
A Family's Story continued from page 10       history of breast cancer and Elizabeth’s   taken if a woman is pregnant or plan-
she did not have an identifiable ge-          age for breast cancer, Ana and Clau-       ning to become pregnant) is on the
netic mutation, expert consensus with         dia both qualified for genetic testing.    same screening schedule. Both women
cancer conference discussions led to the      “Both tests came back negative,” says      see Dr. Jones every 6 months.
physician-patient joint decision for bilat-   Dr. Jones. “But I told them, ‘Just
eral mastectomy. She’s a mom. She has         because you’re negative doesn’t            A Brighter Future?
young kids. Throughout her treatment          mean that your children are out of the     Claudia says, “It’s unfortunate that my
we wanted to help her do all the things       woods.’ If you have a family history of    mom and sister had to have cancer for
that she’s doing right now, to support        cancer, like a mom or sister, you are at   us to be aware and get preventive care.
her through that. She’s in her 30s and        increased risk. So we treat you dif-       When our daughters and nieces get
doesn’t have a nest egg yet, so our cancer    ferently if you report changes in your     older, they will start even sooner.”
center found financial support. Know-         breast. Everything is triaged differ-      Of the sisters, Dr. Jones says, “They
ing there’s more to preventing breast         ently. If you tell me you have a lump,     used to be scared. Now they’re doing
cancer than mammograms, we said,              it’s more worrisome.”                      something about it. Every generation
‘Let’s talk about your diet, your weight,        Dr. Jones conducted a comprehen-        has more hope. Every generation it gets
and your other lifestyle choices.’ And        sive breast cancer risk assessment on      better for them.” g
when her teenage daughter was having a        Ana and Claudia. Then, based on their
hard time seeing her mom with cancer,         risk profiles, she created a personal-     To schedule an appointment or refer a
we helped her find a therapist.”              ized breast cancer prevention program      patient to UT Physicians Multispecialty –
   Elizabeth finished her last round          for each. Dr. Jones prescribed Ana the     Bayshore clinic, call 713.486.6325.
of chemo in January 2021. In March,           hormone therapy drug Tamoxifen, a
she underwent curative intent breast          daily oral medication that prevents                   JESSICA JONES, MD
                                                                                                    Medical Oncologist
surgery at Memorial Hermann-TMC,              cancer cells from using estrogen and                  Assistant Professor, McGovern Medical School
performed by Emily Robinson, MD,              progesterone to grow. Along with                      Leader, Memorial Hermann Breast Cancer
                                                                                                    Prevention Program
professor of surgery at McGovern              preventing cancer, it can help re-
Medical School.                               duce the density of Ana’s very dense
                                              breast tissue—another risk factor for                 EMILY ROBINSON, MD
Ana and Claudia: Personalized 		              breast cancer. Ana has tandem mam-                    Professor of Surgery, McGovern Medical School
                                                                                                    Chair, Memorial Hermann Integrated Network
Preventive Care                               mograms and breast MRIs every 6                       Cancer Committee
Because of Rosa’s personal history of         months. Claudia, who chose not to                     Chair, Texas Medical Center Cancer Committee
breast cancer, the extended family’s          take Tamoxifen (which shouldn’t be

Ahmed Samara:
Back on the Road After Metastatic Melanoma
Ahmed Samara was expecting the                care physician referred him to medical     had in fact spread to his lymph nodes,”
call. His primary care physician had          oncologist Nadya Hasham-Jiwa, DO,          says Dr. Duncan. “Since the cancer had
removed a mole on his back and had            who did a full body scan to see if the     not spread to other organs, his diagno-
sent it out to be examined. But Samara        cancer had spread to other organs. It      sis was stage III metastatic melanoma.”
wasn’t expecting the news.                    had not.                                      Following the surgery, Dr. Hasham-
   “When she called, she said, ‘Are you         She then referred Samara to surgeon      Jiwa started Samara on immuno-
sitting down? Are you driving?’ And I         Casey Duncan, MD, assistant profes-        therapy. After 2 or 3 months, Samara
said, ‘Go ahead. I’m sitting down. I’m a      sor of surgery at McGovern Medical         began to experience swelling in his
big guy. I can take it.’ That’s when she      School, who surgically removed the         underarm, indicative of additional
told me I had cancer,” says Samara.           remainder of the lesion at Memorial        cancer. Dr. Hasham-Jiwa ordered scans,
   Samara’s cancer journey began in           Hermann Southeast Hospital and             which indicated a recurrence of cancer
early 2020 when, within a month, a            simultaneously performed another           in the remaining lymph nodes in his
mole on his back, present since birth,        procedure to evaluate if the cancer had    underarm. She referred him back to Dr.
became much larger and harder. When           spread to the lymph nodes.“We excised      Duncan for a second surgery to remove
the lab results came back diagnosing          the large melanoma on Mr. Samara’s         the remaining lymph nodes.
the lesion as a melanoma, his primary         back and determined that the cancer                            Melanoma continues on page 12

11   MEMORIAL HERMANN CANCER JOURNAL                                                                                         S P R I N G 2 0 21     11
Melanoma continued from page 11                says Samara. “Now I tell people,
   After the second surgery, Samara            if you see something, go and
began radiation therapy under the care         have it checked out, because
of radiation oncologist Theodore Yang,         it’s not worth it. The earlier you
MD. “I did 30 rounds of radiation—             find out, the better. Cancer is
Monday through Friday, 15 minutes a            not a joke.”
day at Memorial Hermann Southeast,                Dr. Duncan says she’s seeing
he recalls. “There was no pain in-             a lot of people, including people
volved, but it made me really weak. If I       in their 20s, with melanoma.
went upstairs to my bedroom and came           “Skin cancer is the most com-
back downstairs, I would have to rest          mon form of cancer in the
before going back upstairs.”                   U.S.,” she says. “The highest
   Samara, 56, who drives a party bus          risk factor for skin cancer is sun
and has a used-car business, completed         exposure and tanning beds.
his radiation treatments and has begun         And the cancer can even show
to feel like his old self again. He is now     up in places that normally
on a targeted therapy and says he has          don’t get sun exposure.”
some residual numbness in his right               She recommends using a
arm, which is expected to dissipate over       sunscreen with at least 30
time. In his follow-up appointment in          SPF, doing regular self skin
March 2021, there was no evidence of           checks and seeing a dermatolo-
cancer.                                        gist once a year, more often if
   “I had no history of skin cancer in my      you’ve been diagnosed with
family. I never even thought about it,”        melanoma.

                                               USPSTF Updates Lung Cancer
                                               Screening Recommendations
                                               On March 9, 2021, the U.S. Preventive Services Task Force (USPSTF) issued an
                                               updated recommendation regarding the use of low-dose computed tomography
                                               (LDCT) to screen for lung cancer. The new recommendation lowers both the
                                               minimum age for screening—from 55 to 50 years of age—as well as the number
                                               of pack-years a person has smoked—from 30 pack-years to 20.

                The USPSTF recommends annual screening for lung cancer with LDCT in adults aged 50 to 80 years who have a
                          20-pack-year smoking history and currently smoke or have quit within the past 15 years.

Lung cancer is the second most common cancer in the U.S. In 2020, an estimated 228,820 people were diagnosed with lung
cancer, and 135,720 people died of the disease. Smoking is estimated to account for about 90 percent of all lung cancer cases,
and the median age of diagnosis of lung cancer is 70 years.
  According to a statement released by the American College of Radiology (ARC) on July 7, 2020, the new screening guidelines
could save 30,000 to 60,000 lives in the U.S. each year.
  Pulmonologist Sandeep Gupta, MD, affiliated with Memorial Hermann Southeast Hospital, who says his clinic has seen as
many as five lung cancer patients a week, applauds the efforts to expand screening. “Lung cancer is the leading cause of can-
cer death among both men and women, comprising about 25 percent of all cancer deaths. Each year, more people die of lung
cancer than of colon, breast and prostate cancers combined. But there is hope. As people continue to stop smoking—and with
advances in early detection and treatment—the death rate from lung cancer continues to drop.”

To schedule a lung cancer screening at Memorial Hermann, visit
memorialhermann.org/services/low-dose-ct-scan/lung-cancer-screening-locations

12   MEMORIAL HERMANN CANCER JOURNAL
ADVANCES IN CANCER TREATMENT

Oncologic Emergencies: Improving Patient Care
Through Enhanced Collaboration
When it comes to oncologic emergen-         rial Hermann Cancer Center clinical           nursing departments and really heard
cies, every second counts.                  pharmacists Nwabugwu “Simone”                 what they had to say. We asked, ‘What
   “Providing excellent care for inpa-      Ndujiuba, PharmD, BCOP; and Brian C.          can we do for you to make treatment for
tients being treated for acute leukemia,    Dinh, PharmD, BCOP.                           our patients better?’ We listened, and we
acute lymphoma, hemophagocytic                 “Our mission is to improve utilization     heard them. Moreover, we acted.”
lymphohistiocytosis (HLH), central          of antidotes and emergent chemotherapy           At the outset, five oncologic emergen-
nervous system tumors and sarcoma           for inpatient oncologic emergencies           cies were identified on which to focus on
requires a multidisciplinary approach,      by updating processes for communica-          initially. These were drawn from across
with everyone operating as a team,” says    tion, guidelines and education through        the four oncologic emergency types—
medical oncologist Jessica Jones, MD,       close collaboration between nursing,          metabolic, hematologic, structural and
assistant professor of oncology at Mc-      pharmacy, laboratory services and             side effects from chemotherapy agents.
Govern Medical School and leader of the     physicians,” says Dr. Rowe. “Multiple         For each emergency, the team performed
new Memorial Hermann Breast Cancer          steps have been involved in this quality      an extensive literature review to create
Prevention Program.                         project, from making project charters to      evidence-based guidelines along with a
   “In the setting of any oncologic         creating education videos for the nursing     process map and educational materials.
emergency that may happen within the        staff. Education and communication are        The education materials were then used
hospital, every department must be clear    integral to making the project a success.”    to conduct interactive in-services for phy-
of the roles and expectations of not only   Once the program received a green light,      sicians, nurses and pharmacy personnel.
their own department but of the other de-   core team members met with the differ-           Based on positive feedback and
partments involved in the patient’s care    ent departments to understand and map         results to date, the team has started
as well,” she says. “And true empower-      out current and desired future states and     to implement the new guidelines
ment requires not just an understanding     what needs to happen to get from the          across the Memorial Hermann
of what needs to happen, but why.”          former to the latter.                         Health System. “What has resulted is
   Last summer, the internal medicine          “It’s a very multidisciplinary ap-         a knowledge and understanding that
residency and oncology fellowship pro-      proach,” says Dr. Jones. “We’ve engaged       is unparalleled, and furthered excel-
grams from McGovern Medical School at       with our pharmacy, laboratory and             lent patient care,” says Dr. Jones. g
UTHealth and the Memorial Hermann
Cancer Center-Texas Medical Center
launched a quality improvement project
to further elevate inpatient oncology
                                            Dale Thornton: Thriving After
patient safety and care. The program is
being led by Dr. Jones and oncologist       Robotic Rectal Cancer Surgery
hematologist Julie Rowe, MD, associate
professor of gastrointestinal malignan-     In eager anticipation of the birth of his     me, I don’t want to know.’ And he told me,
cies at McGovern Medical School.            first grandson, Dale Thornton recently        ‘Dale, that’s the wrong way to think about it.
   The program is a team effort among       pulled his son’s massive Lego collection      It’s when you start hurting that it’s too late.’”
the oncology/hematology fellows,            out of the attic. Having survived rectal         A self-described procrastinator,
including second-years Wei Yang and         cancer, the retired agriculture teacher       Thornton finally took action two years
Frances Cervoni-Curet and first-years       from Alvin, Texas, now realizes the value     later. “I was sitting on my patio, and
Binou Yohannan and Arthi Sridhar,           of taking proactive care of this health.      a feral cat jumped onto my fence and
working alongside Adan Rios, MD, pro-          This wasn’t always the case. “The day I    bit me,” he says. “While I was on the
fessor of hematological malignances         retired, a co-worker came into my shop to     phone with a doctor about the cat bite,
at McGovern Medical School; Neha            congratulate me, and I mentioned to him       I scheduled a full physical. And I’ve
Maithel, MD, assistant professor of         that I had never had a physical,” recalls     been getting annual physicals ever
genitourinary malignancies at Mc-           Thornton. “I was 57, and I said, ‘Now that    since.”
Govern Medical School; and Memo-            I’m retired, if there’s anything wrong with                   Rectal Cancer continues on page 14

13   MEMORIAL HERMANN CANCER JOURNAL                                                                                     S P R I N G 2 0 21   13
Rectal Cancer continued from page 13        as much healthy tissue and function-          On November 17, 2020, Dr. Askenasy
   During his physical in 2018, a stool     ality as possible,” says Dr. Askenasy.     performed the 2 ½-hour procedure at
sample revealed blood in his stool. His     “Traditional surgery for rectal cancer     Memorial Hermann Southeast. Thorn-
primary care physician referred him to      requires an incision down the middle       ton recalls waking up to good news. “Dr.
colon and rectal surgeon Erik Askenasy,     of the abdomen, which can mean             Askenasy said, ‘Dale, I’ve got nothing
MD, an assistant professor in the Depart-   longer recovery times. This minimally      but good news. The cancer’s gone, you
ment of Surgery at McGovern Medical         invasive approach allows us to make        don’t need to wear an ostomy bag and
School, who is affiliated with Memorial     smaller incisions, which can decrease      you don’t need radiation. You just need
Hermann Southeast Hospital.                 pain, shorten hospital stays, speed        to get checked at least once a year.’”
   Dr. Askenasy performed a flexible        recovery and lower the occurrence of       The day after his surgery, Thornton was
sigmoidoscopy, which revealed two           post-operative complications, such as      released to go home.
lesions on Thornton’s rectum. Pathol-       infections.”                                  Asked what advice he would give to
ogy and imaging results confirmed that         Prior to the surgery, Dr. Askenasy      others who are putting off getting regu-
Thornton had stage I rectal cancer. “I      described the procedure and po-            lar cancer screenings, including their
presented Mr. Thornton’s case to our        tential outcomes to Thornton. “Dr.         colonoscopies, Thornton replies, “I
cancer conference, and the recommen-        Askenasy explained that he would be        tell people, I have no history of cancer
dation was to perform surgery up front.     removing the cancerous part of my          in my family. I am in good health. It can
It was determined that the patient          rectum then would reattach my colon        get you too. Don’t wait.” g
was a good candidate for minimally          to the remaining part of my rectum.
invasive robotic low anterior resection     He said, worst case, I would spend 3
                                                                                                 ERIK ASKENASY, MD
(RLAR),” says Dr. Askenasy.                 to 5 nights in the hospital, and there               Colon and Rectal Surgeon
   “The goal of rectal cancer surgery is    was a small chance I might need                      Assistant Professor, Department of Surgery,
to completely remove the cancer and         to wear an ostomy bag for several                    McGovern Medical School

associated lymph nodes while sparing        months,” recalls Thornton.

Transoral Robotic Surgery Speeds Throat Cancer
Patient Recovery
                                            School and is affiliated with Memorial     cancer occurs in the back of the throat
                                            Hermann-Texas Medical Center. He           and includes the base of the tongue
                                            says prior to utilizing this minimally     and tonsils. Oral and oropharyngeal
                                            invasive approach, surgeons had to         cancers are the eighth most common
                                            perform open surgery on the patient.       cancer among men. Smoking or being
                                            “We basically had to split the patient’s   infected with the human papilloma-
                                            jaw to remove cancers in the back of       virus (HPV) can increase the risk of
                                            the throat and use a tracheostomy—a        oropharyngeal cancer. HPV is believed
                                            breathing tube in the neck—and feed-       to cause 70 percent of oropharyngeal
                                            ing tube.”                                 cancers in the U.S.
                                               Now, with the robot, the surgeon           In 2009, the U.S. Food and Drug
                                            is able to place two robotically guided    Administration approved transoral
                                            instruments, acting as the surgeon’s       robotic surgery for early state oropha-
                                            arms, into the patient’s mouth to safely   ryngeal cancer. Robotic surgery for pa-
Head and neck surgeon Kunal Jain,           remove tumors. As a result, patients can   tients with early stage, oropharyngeal
MD, is helping patients with throat         leave the hospital in 2 to 3 days rather   squamous cell cancer has been associ-
cancer recover faster and avoid chemo-      than 2 weeks, and they are potentially     ated with improved health outcomes,
therapy and radiation treatments with       able to avoid radiation therapy and che-   including better long-term survival,
transoral robotic surgery (TORS) at         motherapy and their side effects.          according to a Cedars-Sinai study pub-
Memorial Hermann.                              In 2021, an estimated 54,010 adults     lished in the August 20, 2020, issue of
  Dr. Jain is assistant professor of head   (38,800 men and 15,210 women) in           JAMA Oncology.
and neck oncology and microvascular         the U.S. will be diagnosed with oral and      Dr. Jain is one of a handful of sur-
reconstruction at McGovern Medical          oropharyngeal cancer. Oropharyngeal                      Throat Cancer continues on page 15

14   MEMORIAL HERMANN CANCER JOURNAL
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