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Basic Science Abstracts
MDS Virtual
Congress 2020
SEPTEMBER 12 – SEPTEMBER 16
www.mdscongress.org
MDS-0820-029MDS Virtual Congress 2020 Basic Science Abstracts
_________________________________________________________
22 87
Modeling Cerebellar Limb Dysmetria and Compared the effects of probiotics and Anti-PD
Impaired Spatial Memory in Rats Using particles on the behavior of Parkinson's
Lamivudine: A preliminary study disease mice model
E. Akang, O. Dosumu, S. Afolayan, R. Agumah, A. X.H. Zhao, Y.B. Wang, J. Yang, L.Y. Zhang, H.Q.
Oremosu, A. Akanmu (Anatomy, College of Liu, H.J. Sui (The People’s Hospital of Pudong)
Medicine, University of Lagos.)
105
23
Abrogation of neuroinflammation and
Novel Dentato-Olivo-Luysian Atrophy in a
behavioural deficit by Chlorogenic acid and
Greek Family
Tinosporia cordiofolia in MPTP-Induced
S. Alshimemeri, K. Yoshida, N. Visanji, E.
Parkinsonian mice model via suppressing NF-
Rogaeva, R. Munhoz, E. Slow, A. Lang, G. Kovacs
κB pathway
(The Edmond J Safra Program in Parkinson's
D. Singh, M. Singh (SHUATS)
Disease, Toronto Western Hospital, University
Health Network)
127
Mutation screening and clinical features
46
analysis in patients with early-onset primary
Genetic, biochemical and clinical findingss in
dystonia
Friedreich’s ataxia patients – relationship with
X.J. Gu, J. Yang, L.Y. Zhang, Q.Q. Wei, H.F.
the disease severity
Shang (West China Hospital, Sichuan University)
R. Moganty, D. Pathak, A. srivastava, s. Gulati (All
India Institute Of Medical Sciences)
128
Concordance of different evaluation
58
approaches of non-motor symptoms in patients
Clinical and genetic abnormalities in patients
with cervical dystonia
with Friedreich's ataxia: A genotype-phenotype
V. Han, K. Kulcsarova, J. Ventosa, Z. Gdovinova,
correlation
M. Skorvanek (Safarik University)
I. Singh, I. Ahmed, S. Shaykya, A. Srivastava (All
India Institute of Medical Sciences)
130
Frequency and phenotypic spectrum of ANO3
60
dystonia: A single-center cohort study
Clinical correlation with the Genotype of
L.T. Jiang, L.X. Li, Y. Liu, X.L. Zhang, Y.G. Pan,
Friedreich’s Ataxia (FRDA) patients in Indian
L.J. Jin (Shanghai Tongji Hospital, Tongji
population
University School of Medicine)
A.K. Srivastava, I. Ahmad, P. Sharma, M. Seth, U.
Shamim, I. Singh, R. Rajan, MV.P. Srivastava, F.
142
Mohammad (All India Institute of Medical Sciences)
The Dystonia Coalition Natural History Project:
An Available Research Resource
68
S. Norris, H. Jinnah, L. Wright, G. Kilic-Berkmen, J.
Nivolumab-induced choreoathetosis in a
Hieshetter, D. Peterson, S. Pirio-Richardson, J.
woman with lung cancer – A case report with
Perlmutter (Washington University School of
review of the literature
Medicine)
J. Johansson Lindgren, M. Esbjörnsson, E. Tüzün,
H. Griph, D. Van Westen, G. Sahin (Hässleholm
146
Hospital)
Development of novel treatment strategies for
SGCE dystonia using patient-derived induced
74
pluripotent stem cells (iPSCs)
Case Report: Pseudoatetosis as Manifestation
S. Staege, A. Kutschenko, P. Seibler, K. Grütz, A.
of the Vitamin B12 Deficit
Hermann, F. Wegner (Hannover Medical School)
J. Vargas (MÉDERI/HIJS)155 228
Neural bases of dystonia penetrance and The role of polymorphic allelic variants of the
manifestation VEGFα and TGFβ gene in the development of
S. Khosravani, G. Chen, K. Simonyan (Mass. Eye cerebrovascular disorders in patients with
and Ear Infirmary) metabolic syndrome
S.h. Shokhimardonov, S.h. Xudjanov, F.
161 Shermuhammedova, S.h. Kuzieva (Tashkent
Regional, Not Global, Functional Connectivity Medical Academy)
Contributes to Isolated Focal Dystonia
S. Norris, A. Morris, M. Campbell, M. Karimi, A. 231
Babatunde, R. Paniello, A. Snyder, J. Mink, J. First Scientific Description of the Hepato-
Perlmutter (Washington University School of Lenticular Degeneration
Medicine) D. Labunskiy, S. Kiryukhina, N. Kolmykova
(Ogarev Mordovia State University)
165
Difference in pallidal single unit activity in 249
cervical dystonia with jerky and sinusoidal Cardiovascular risk factors in a pre-manifest
head tremor and manifest population of Huntington's
A. Sedov, S. Usova, U. Semenova, A. Gamaleya, disease
A. Tomskiy, H. Jinnah, A. Shaikh (Semenov E. Gatto, N. Gonzalez Rojas, M. Cesarini, J.
Institute of Chemical Physics, Russian Academy of Etcheverry, G. Da Prat (Instituto Neurociencias
Sciences) Buenos Aires (INEBA))
168 253
Distinct maladaptive and compensatory wiring Cytokines and Brain Specific Antibodies in
patterns in penetrant and non-penetrant Experimental Cellular and Molecular Treatment
dystonia mutation carriers of Huntington's Diseases
A. Vo, K. Schindlbeck, N. Nguyen, A. Rommal, M. D. Labunskiy, S. Kiryukhina, V. Podsevatkin
Niethammer, D. Eidelberg (The Feinstein Institute (Ogarev Mordovia State University)
for Medical Research)
266
184 The roles of Huntingtin Associated Protein 40
Age at onset and Parkinson’s disease in Huntingtin functions and Huntington’s
progression disease pathogenesis
G. D'Urso, K. Taylor, T. Kustermann, N. Pavese, S. Xu, G. Li, X. Ye, L. Ye, Z. Xu, E. Furr Stimming,
G. Pagano (Roche Pharma Research and Early S. Zhang (The Brown Foundation Institute of
Development, Neuroscience and Rare Diseases Molecular Medicine, McGovern Medical School at
Discovery and Translational Area) the University of Texas Health Science Center at
Houston)
188
Incidence and survival of psychosis in patients 293
with Parkinson’s Disease (1991-2010) 4-Chlorokynurenine inhibits L-Dopa-induced
M. Hajeb, C. Stang, E. Camerucci, T. Turcano, A. dyskinesias in non-human parkinsonian
Mullan, P. Martin, V. Abler, M. Splett, N. Rashid, J. primates
Bower, M. Mielke, R. Savica (Myo Clinic) T. Di Paolo, M. Bourque, R. Snodgrass (CHU de
Quebec-Université Laval)
210
Quantitative method for designing appropriate 294
longitudinal follow-up frequency with Copper induced neurobehavioral features of
application to Parkinson’s disease cognition Parkinson’s disease and oxidative stress and
research their abatement by Eugenol
L. Suttner, S. Xie (Department of Biostatistics, A. Kumar, B. Sharma (University of Allahabad)
Epidemiology and Informatics; University of
Pennsylvania)295 320
hUC-MSCs ameliorated CUMS-induced Hospitalization causes and condition at
depression by modulating complement C3 discharge of Parkinson's disease patients in
signaling-mediated microglial polarization Mexican public institutions between 2011 and
during astrocyte-microglia crosstalk 2017
J. Li, H.L. Wang, M.W. Wang (Department of R. Janssen-Aguilar, V. Villasuso-Alcocer, C. Rivas-
Neurology, the First Hospital of Hebei Medical Berny, N. Méndez-Domínguez, R. Leal-Ortega
University) (Universidad Marista de Mérida)
296 324
Perillyl alcohol restores mitochondrial Visuomotor reaction time can predict IQ in
dysfunction and abridge NLRP3 children
inflammasomes activation in in-vitro and in- S. Kiselev (Ural Federal University)
vivo model of Parkinson's disease
P. Panda, S. Ahmed, V. Naidu (NIPER-Guwahati) 326
A novel phasic and restricted basal ganglia
297 thalamocortical subcircuitry model
Neuroprotective effects of allicin D. Kumbhare, G. Weistroffer, M. Baron (Virginia
microemulsion against intrastriatal rotenone Commonwealth University)
and manganese induced Parkinsonism in rats
S. Singh (ISF College of Pharmacy) 335
Endovascular therapy in acute ischemic
298 stroke(AIS)
Preclinical pharmacology and early clinical M. Munteanu (Regina Maria Private Medical Care)
development of dopamine D1 positive allosteric
modulators (D1PAMs) with therapeutic 346
potential for neuropsychiatric disorders Effect of herbal medicine against Parkinson’s
K. Svensson, H. Meltzer, K. Biglan (Eli Lilly and Diseases- An in silico studies
Company) S. Subramani, Y. Gupta, R. Sharma, P. Prasad
(Jiwaji University)
299
Oral treatment of the SOD1G93A transgenic 35
mouse model of amyotrophic lateral sclerosis Identification and characterization of anti-
(ALS) with the neuro-inflammation inhibiting prionic compounds that disassemble Tau
compound PRI-003 prions as a novel therapeutic approach for
D. Willbold, J. Post-Schulz, A. Schaffrath, A. tauopathies
Willuweit, J. Kutzsche (Forschungszentrum Jülich) D. Willbold, T. Altendorf, W. Hoyer, J. Mohrlüder
(Forschungszentrum Jülich)
305
Hyperpolarization of the subthalamic nucleus 371
alleviates hyperkinetic movement disorders Unraveling the role of amylin oligomers in
C.-H. Tai, S.-H. Tseng, T.-R. Wang, M.-T. Hsu, C.- synucleinopathies
C. Kuo (National Taiwan University Hospital) I. Martinez Valbuena, R. Valenti Azcarate, C.
Caballero, I. Marcilla Garcia, I. Amat-Villegas, J.
311 Sanchez, G. Marti-Andres, L. Armengou, M.R.
MR Conditional Labeling for DBS – Basic Luquin Piudo (Center for Applied Medical
Physics for the Non-Specialist Research and Clinica Universidad de Navarra -
M. Conroy, S. Falowski, D. Sayed, L. Poree, K. University of Navarra)
Chakravarthy, R. Banerjee, J. Kramer (Medtronic)
374
313 Development and Characterization of an
Paroxysmal Kinesigenic Dyskinesia: Case Ultrasensitive Assay Platform for Detection of
series from Çukurova University, Turkey PD Associated alpha-Synuclein Oligomers in
M. Demirkiran, M. Balal, A. Bisgin, S. Bozdogan Human Blood
(Cukurova University School of Medicine) D. Robakis, A. Chiu, B. Chang, R. Rubenstein
(SUNY Downstate Health Sciences University)376 451
Discrimination of alpha-synuclein strains and Neuroprotective propensity of marmelosin
sub-strains in Synucleinopathies against 6-OHDA-induced cognitive impairment
M. Shahnawaz, A. Mukherjee, S. Pritzkow, N. and apoptosis via upregulation of PI3K/Akt
Dinamarca, F. Wang, P. Rabadia, C. Soto (Mitchell pathway
Center for Alzheimer’s disease and Related Brain E. Yadav (Sam Higginbottom University of
Disorders, University of Texas Medical School at Agriculture Technology & Sciences)
Houston)
452
394 Identification and clinical characteristics of
The role of attention networks in walking in Mild Cognitive Impairment in Parkinson’s
Parkinson’s disease disease
R. Drake, G. Eskes (Dalhousie University) J. Yang, E. Forbes, D. Pourzinal, K. McMahon, D.
Copland, G. Byrne, J. O'Sullivan, L. Mitchell, N.
399 Dissanayaka (University of Centre for Clinical
Regional cortical thickness alterations in PD Research)
patients with cognitive impairment
V. Goyal, S. Chaudhary, A. Ankeeta, S. Kumaran, 453
P. Bhat (Medanta, The Medicity) Cerebral microvascular injury provoked by
alpha-synuclein preformed fibrils exacerbates
422 cognitive dysfunction in Parkinson's disease
How Parkinson’s Disease Affects Working Q.X. Zhang, Y.Y. Gao, L.J. Wang (Guangdong
Memory Provincial People’s Hospital)
L. Montaser Kouhsari, A. Bakkour, D. Shohamy
(Columbia University) 456
Cognitive profiling of patients with
427 neurodegenerative disorders
Decreased Regional Cholinergic Signaling in I. Zhukova, E. Kolupaeva, N. Zhukova, O.
Parkinson's Disease Izhboldina, M. Nikitina, A. Latipova, S. Shtaymets,
J. O'Donnell, Y. Zhou, M. Campbell, S. Mansor, B. I. Mironova, Z.h. Kislukhina, L. Tkachenko, A.
Maiti, Z. Tu, J. Perlmutter (Washington University Agasheva, D. Novotnyy (Siberian State Medical
School of Medicine) University)
432 457
Comparison of gait pattern characteristics Parkinson’s disease polygenic risk score and
during Parkinson's disease progression - brain structure in neurologically healthy
Analysis of gait during the dual-task walking individuals
S. Radovanovic, V. Markovic, I. Stankovic, S. N. Abbasi, L. Krohn, U. Vainik, Z. Gan-Or, A.
Gluscevic, I. Petrovic, V. Kostic (Institute for Dagher (McConnell Brain Imaging Centre,
Medical Research, University of Belgrade) Montreal Neurological Institute, McGill University)
444 458
Clock Drawing Test does not Differentiate The study of the role of genetic risk factors in
Alzheimer’s Disease from Parkinson’s Disease levodopa-induced dyskinesia development in
Dementia Russian patients with Parkinson's disease: a
S. Tezcan Aydemir, M. Kuzu Kumcu, C. pilot study
Akbostancı (Sincan Dr. Nafiz Körez Government G. Akhmadeeva, I. Khidiyatova, I. Gilyazova, A.
Hospital) Baitimerov, G. Tayupova, R. Magzhanov (Institute
of Biochemistry and Genetics Ufa Research Study
450 Center)
Candidate plasma miRNAs and EV protein as
novel biomarkers in Parkinson's disease
patients with cognitive impairment and
dementia
R.-M. Wu, Y.Z. Tsai, M.-C. Kuo, Y.u. Yoshioka,
Ko.j. Ueda, Ta.k. Ochiya, S.-P. Lin (Neurology,
National Taiwan University Hospital, College of
Medicine, National Taiwan University)459 ………………………………………………………….
Longitudinal Measurements of 474
Glucocerebrosidase activity in Parkinson’s Virtual Assessment of LRRK2 Carriers to
patients and controls: the PPMI study Optimize Research in Parkinson Disease
R. Alcalay, P. Wolf, MS.R. Chiang, K. Helesicova, (VALOR-PD): A Comparison to Traditional
X.K. Zhang, K. Merchant, S. Hutten, C. Scherzer, Cohorts
C. Caspell-Garcia, C. Blauwendraat, K. Nudelman, S. Jensen-Roberts, T. Myers, K. Amodeo, S.
T. Foroud, Z. Gan-Or, T. Simuni, L. Chahine, O. Sharma, R. Alcalay, E. Dorsey, R. Holloway, R.
Levy, D. Zheng, G. Li, P. Sardi (Columbia Schneider (University of Rochester)
University)
475
463 A Fluctuating Qualitative Dermatoglyphic Trait,
An introduction to the Global Parkinson's Dankmeijer’s and Furuhata’s Index as a Risk
Genetics Program (GP2) Marker in Diabetic Parkinson’s Patients of
C. Blauwendraat, E. Riley, A. Singleton (National Guyana: A Case-Control Study
Institutes on Aging) A. Jha, S. D'costa, W. White, M. Chapp, D. Kanhai
(University of Nicaragua)
469
Northwestern University Feinberg School of 483
Medicine Parkinson’s disease and Movement Sex-specific neuroprotection by inhibition of
Disorders Center Biorepository: bringing the the Y-chromosome gene, SRY, in experimental
clinic and lab together Parkinson's disease
A. Hernandez, S. Lubbe, T. Simuni, D. Bega, D. J. Lee, P. Pinares-Garcia, H. Loke, S. Ham, E.
Krainc, N. Mencacci, R. Modiest, P. Opal, C. Vilain, V. Harley (Hudson Institute of Medical
Taylor, N. Shetty, R. Malkani, J. Blackburn Research)
(Northwestern University)
489
471 Parkinson’s disease polygenic risk prediction
Moderately frequent and private variants in and haplotype analysis in a South American
PRKN are associated with late-onset cohort
Parkinson’s disease D. Loesch, A. Horimoto, E. Sarihan, M. Cornejo-
F. Hopfner, S.M. Müller, S.S. Szymczak, O. Junge, Olivas, L. Torres, M. Inca-Martinez, P. Mazzetti, C.
L. Tittmann, S. May, K. Lohmann, G. Grallert, B. Cosentino, E. Dieguez, V. Raggio, A. Lescano, V.
Schormair, J. Winkelmann, B. Mollenhauer, C. Tumas, V. Borges, H. Ferraz, C. Rieder, A.
Trenkwalder, W. Maetzler, D. Berg, M. Kasten, C. Schumacher-Schuh, B. Lopes Santos-Lobato, C.
Klein, G. Hoeglinger, T. Gasser, G. Deuschl, A. Velez-Pardo, M. Jimenez-Del-Rio, F. Lopera, P.
Franke, M. Krawczak, A. Dempfle, G. Chana-Cuevas, W. Fernandez, G. Arboleda, H.
Kuhlenbäumer (Hannover Medical School) Arboleda, C. Arboleda-Bustos, D. Yearout, C.
Zabetian, T. Thornton, T. O'Connor, I. Mata
473 (University of Maryland School of Medicine)
Beta-Glucocerebrosidase Activity in GBA-
linked Parkinson's Disease: The Type of 499
Mutation Matters Interest of multiplex ligation-dependent probe
Y.E. Huh, M.S. Chiang, J. Locascio, Z. Liao, G. Liu, amplification assay to identify pathogenic
K. Choudhury, Y. Kuras, I. Tuncali, A. Videnovic, A. mutations in Parkinson’s disease patients
Hunt, M. Schwarzschild, A. Hung, T. Herrington, M. E. Mutez, M. Swiderski, L. Defebvre, M.C. Chartier-
Hayes, B. Hyman, A.-M. Wills, S. Gomperts, J. Harlin, V. Huin (Univ. Lille, Inserm, CHU Lille,
Growdon, S. Sardi, C. Scherzer (APDA Center for U1172 - LilNCog - Lille Neuroscience & Cognition)
Advanced Parkinson Research, Harvard Medical
School, Brigham & Women's Hospital) 502
Sensitive biomarker of Parkinson’s disease
………………………………………………………… linked to mutations in the glucocerebrosidase
………………………………………………………… gene
………………………………………………………… S. Pchelina, M. Nikolaev, A. Kopytova, G.
………………………………………………………… Baydakova, K. Senkevich, I. Miliukhina, T. Usenko,
A. Emelyanov, E. Zakharova (Petersburg Nuclear
Physics Institute, NRC “Kurchatov Institute”)505 515
LRRK2 p.G2019S and p.N2081D variants as TET2-mediated Cdkn2A DNA
modifiers of glucocerebrosidase activity hydroxymethylation in dopaminergic neuronal
K. Senkevich, E. Yu, L. Krohn, U. Rudakou, J. injury of Parkinson's disease
Ruskey, F. Asayesh, K. Mufti, S. Laurent, D. Y.C. Wu, T.T. Wu, X. Li, T. Liu (Department of
Spiegelman, S. Fahn, C. Waters, P. Sardi, G. Neurology, Shanghai General Hospital, Shanghai
Rouleau, R. Alcalay, Z. Gan-Or (Montreal Jiao Tong University School of Medicine)
Neurological Institute, McGill University)
516
508 Effect of P2X4 Signal Axis on Iron Metabolism
Burden of variants in Parkinson’s disease- in Parkinson’s Disease Animal Model
associated genes in GBA mutation carriers A. Xie, J. Gao, J. Ma (Affiliated Hospital of Medical
Y.L. Sosero, E. Yu, P. Saini, L. Krohn, U. Rudakou, College Qingdao University)
J. Ruskey, F. Asayesh, M. Estiar, S. Fahn, C.
Waters, O. Monchi, Y. Dauvilliers, A. Espay, N. 517
Dupré, L. Greenbaum, G. Rouleau, S. Hassin- H1/H2 MAPT Haplotype and Parkinson's
Baer, E. Fon, R. Alcalay, Z. Gan-Or (McGill Disease in an Ashkenazi Jewish Cohort
University) G. Yahalom, L. Greenbaum, S. Israeli-Korn, T.
Fay-Karmon, V. Livneh, S. Hassin-Baer, Z. Gan-
509 Or, J. Ruskey, E. Leveille, U. Rudakou, L. Krohn,
DJ1 and α-Synuclein as CSF biomarkers and G. Rouleau (Saare Zedek Medical Center)
gene polymorphisms: association with clinical
parameters in Parkinson’s disease 521
T. Syed, T. SD, R. Kandadai, V. Kutala, R. GCH1 variants contribute to risk and earlier age
Borgohain (Nizam's Institute of Medical sciences) at onset in Parkinson's disease
Y. Zhao, H. Pan, Q. Sun, Q. Xu, X. Yan, J. Li, B.
Tang, J. Guo (Xiangya Hospital, Central South
511
University)
Is early-onset of levodopa-induced dyskinesia a
predictor of GBA mutation? A next-generation
sequencing study of young-onset Parkinson’s 523
disease patients in Thailand Type-3 Metabotropic Glutamate Receptors and
S. Thanprasertsuk, P. Phowthongkum, T. Parkinson’s Disease: Preclinical Studies and
Hopetrungraung, C. Poorirerngpoom, T. Human Genetics
Satirapatya, P. Wichit, O. Phokaewvarangkul, K. M. Alborghetti, L. Di Menna, A. Traficante, V.
Vongpaisarnsin, S. Bongsebandhu-phubhakdi, R. Bruno, J. Monn, F. Nicoletti, F.E. Pontieri, E.
Bhidayasiri (Faculty of Medicine, Chulalongkorn Bianchini, G. Spalletta, M. Borro, M. Simmaco, G.
University) Battaglia (Neuroscience, Mental Health and
Sensory Organs (NESMOS))
512
mRNA level and variants of the SCARB2 gene 526
in the pathogenesis of Parkinson’s disease Male-specific exacerbation of susceptibility to
T. Usenko, A. Bezrukova, D. Bogdanova, A. α-synuclein pre-formed fibrils by
Kopytova, A. Emelyanov, I. Miliukhina, A. developmental dieldrin exposure in mice
Timofeeva, S. Pchelina (Petersburg Nuclear A. Bernstein, A. Gezer, J. Kochmanski, S.
Physics Institute named by B.P.Konstantinov of VanOeveren, A. Cole-Strauss, C. Kemp, J.
NRC «Kurchatov Institute») Patterson, K. Miller, N. Kuhn, D. Herman, A.
McIntire, J. Lipton, K. Luk, S. Fleming, C. Sortwell
(College of Human Medicine, Michigan State
513
University)
LIPAD (LRRK2/Luebeck) International
Parkinson’s Disease Study: Detecting genetic
and environmental modifiers of penetrance and 527
disease expression Characterization of Lewy bodies-induced
T. Usnich, N. Schell, E.-J. Vollstedt, V. Skrahina, X. neurodegeneration and synucleopathy in wild-
Bogdanovic, N. Koleva-Alazeh, I. Csoti, T. Förster, type mice
A. Heuer, N. Brüggemann, P. Bauer, M. Kasten, A. E. Bezard, L. Zhang, X. Yu, X. Sun, Y. Zhang, G.
Rolfs, C. Klein (Institute of Neurogenetics) Ran, S. Dovero, M. Persillet, P. Fernagut, B.
Dehay, C. Qin (Institute of Neurodegenerative
Diseases)528 536
Glucocerebrosidase Deficiency Mediates The role of peripheral T- and B-lymphocytes in
Propagation of Protein Aggregation via LRRK2-mediated Parkinson’s disease
Extracellular Vesicle Dysregulation E. Kozina, M. Byrne, L. Oakley, R. Smeyne
K. Jewett, R. Thomas, C. Phan, G. Milstein, S. Yu, (Jefferson Hospital for Neuroscience, Thomas
L. Pallanck, M. Davis (University of Washington) Jefferson University)
529 537
Emergence of stealth polymorphs that escape miRNA sequencing from routine colonic
α-synuclein amyloid monitoring, take over and biopsies reveals an enrichment of submucosal
acutely spread in neurons hsa-miRNA-486-5p in Parkinson's disease
F. De Giorgi, F. Laferriere, F. Zinghirino, E. A. Kurz, R. Kumar, C. Wenk, B. Nordhoff, J.
Faggiani, A. Lends, M. Bertoni, X. Yu, A. Gérard, Schirra, S. Donakonda, G. Höglinger, K. Bötzel, L.
E. Morvan, B. Habenstein, N. Dutheil, E. Holdt, T. Koeglsperger (German Center for
Doundnikoff, J. Daniel, S. Claverol, C. Qin, A. Neurodegenerative Diseases (DZNE))
Loquet, E. Bezard, F. Ichas (Institute of
Neurodegenerative Diseases) 538
Alpha-synuclein DNA methylation in CD45+
530 blood cells in Parkinson’s disease
Auxilin knockout mice: a model for A. Lavrinova, N. Melnikova, A. Dmitriev, I.
Parkinsonism with dopamine dysregulation and Miliukhina, E. Litusova, P. Gagarina, O. Berkovich,
synucleinopathy S. Pchelina, A. Emelyanov (Petersburg Nuclear
V. DJ, S. Chandra (Yale University School of Physics Institute named by B.P. Konstantinov of
Medicine) National Research Centre «Kurchatov Institute»)
532 539
Intrastriatal injection of alpha-synuclein Effects of exosomes devised from
preformed fibrils results in cognitive dopaminergic neurons overexpressing α-
dysfunction and L-DOPA reversible synuclein on autophagy and inflammation in
sensorimotor impairments in rats microglia
S. Fleming, J. Patterson, L. Yan, C. Kemp, K. Y. Liang, L. Bu, E. Tao (Sun Yat-sen Memorial
Miller, A. Stoll, M. Duffy, D. Herman, J. Lipton, K. Hospital of Sun Yat-sen University)
Luk, J. Goudreau, C. Sortwell (Northeast Ohio
Medical University) 540
Gut Microbiota in Parkinson’s disease:
534 influences of device-assisted therapies
Screening of mutations in PARK2 gene and M. Lubomski, X. Xu, A. Holmes, J. Yang, R. Davis,
Dopamine levels in Parkinson's disease (PD) C. Sue (Royal North Shore Hospital)
patients in Coimbatore population, India
I. Iyer, V. Venkatesan, V. Vellingiri (Avinashilingam 541
Institute for Home Science and Higher Education L-DOPA treatment in N2a cells stimulates
for Women) neuromelanin biosynthesis: Using a novel in
vitro model to examine the effect of iron and
535 light on neuromelanin production
The Fragile X Mental Retardation Protein is lost S. Martin, V. Jones, J. Taylor, S. Lane, J. Ehlting,
prior to the appearance of Lewy pathology in A. Helton, P. Walter (University of Victoria)
Parkinson’s disease
T. Koeglsperger, Y. Tan, C. Sgobio, T. Arzberger, 543
F. Machleid, Q. Tang, E. Findeiss, J. Tost, T. Loss of CHCHD2 and CHCHD10 disrupts
Chakroun, P. Gao, M. Höllerhage, K. Bötzel, J. mitochondrial cristae phenocopying patient
Herms, G. Höglinger (German Center for mutations
Neurodegenerative Diseases (DZNE)) D. Narendra, Y. Liu, X. Huang, D. Nguyen, M.
Shammas, B. Wu, E. Dombi, D. Springer, J.
Poulton, S. Sekine (National Institute of Neurologic
Disorders and Stroke)544 558
A novel peptide reduces α-synuclein levels and Cancerous inhibitor of protein phosphatase 2A
neurodegeneration in cell, invertebrate, and in Parkinson’s disease
mammalian models of Parkinson’s disease S.J. Yin, C. Han, T. Wang (Union Hospital, Tongji
D. O'Hara, S. Nim, K. Hall, M. Kapadia, M. De Medical College, Huazhong University of Science
Snoo, H. Chau, S. Ngana, C. Corbi-Verge, A. and Technology)
Perez-Riba, S. Kalia, L. Kalia, P. Kim (Krembil
Research Institute) 562
Spatiotemporal Changes in Substantia Nigra
549 Neuromelanin Content from Prodromal to
Compartment-specific blockade of dopamine Clinical Parkinson’s Disease
uptake in nigrostriatal pathway reveals role for E. Biondetti, R. Gaurav, L. Yahia-Cherif, G.
nigral dopamine function in movement Mangone, N. Pyatigorskaya, R. Valabrègue, C.
frequency in open-field Ewenczyk, M. Hutchison, C. François, J.-C. Corvol,
M. Salvatore, E. Kasanga, K. Lanza, S. Meadows, M. Vidailhet, S. Lehéricy (Institut du Cerveau et de
A. Centner, C. Bishop (University of North Texas la Moelle épinière – ICM, INSERM U 1127, CNRS
Health Science Center Fort Worth) UMR 7225, Sorbonne Université)
550 578
α-Synuclein propagation via olfactory pathway Investigating Substantia Nigra Damage using
induces olfactory bulb atrophy and widespread Fully Automated Segmentation of
glucose hypometabolism in a non-human Neuromelanin MRI in Early Parkinson’s Disease
primate model R. Gaurav, R. Valabregue, L. Yahia-Cherif, N.
M. Sawamura, H. Onoe, H. Tsukada, K. Isa, N. Pyatigorskaya, G. Mangone, E. Biondetti, C.
Uemura, T. Isa, R. Takahashi (Graduate school of Ewenczyk, M. Hutchison, J.C. Corvol, M. Vidailhet,
Medicine, Kyoto University) S. Lehéricy (Brain and Spine Institute – ICM)
551 591
Profile of miRNA expression in CSF of Hyposmia as a biomarker in patients with
Parkinson’s disease identifies miR-409-3p Parkinson’s disease and atypical Parkinsonism
regulating the apoptosis of dopamine neurons S. Kumaran, A. Ankeeta, S. Chaudhary, P. Bhat, V.
X.L. Tan, J.Q. Tan, F.Y. Ming, L.L. Lv, H.N. Zhang, Goyal (All India Institute of Medical Sciences)
B.S. Tang, W.Q. Yan, R.R. Bai, X.K. Peng, Q.L.
Xiao, C.Y. Wang (The Second Xiangya Hospital, 600
Central South University) Graph theory analysis of dopamine D2 receptor
network in Parkinson's disease patients
553 A. Mihaescu, J. Kim, S. Cho, M. Diez-Cirarda, M.
Protective role of astrocytes on α-synuclein Valli, Y. Koshimori, A. Strafella (Centre for
accumulation and propagation Addiction and Mental Health)
T. Tsunemi, Y. Ishiguro, A. Yoroisaka, K. Krainc, N.
Hattori (Juntendo University School of Medicine) 605
Parkinson's Disease Exhibits Longitudinal
554 Increases in beta-Amyloid in the Striatum and
Increased expression of conexin 36 in rodent Cingulate Gyrus
model of Parkinson disease J. O'Donnell, Y. Zhou, M. Campbell, B. Maiti, J.
M. Viegas, L. Santos, F. Scorza, C. Scorza, A. Perlmutter (Washington University School of
Rodrigues, A. Almeida (Universidade Federal de Medicine)
São João del rei)
614
555 Intrinsic Remodeling of the Fovea is Correlated
The Influence of 3-Phenoxybenzoic Acid in with Contrast Sensitivity Loss in Parkinson’s
Dopaminergic Degeneration Disease
F. Wan (Union Hospital, Tongji Medical College, E. Pinkhardt, A. Ding, S. Slotnick, J. Kassubek, A.
Huazhong University of Science and Technology) Ludolph, S. Glazman, I. Selesnick, I. Bodis-Wollner
(Ulm University)615 651
Retinal Pathology in Parkinson’s Disease: A In vivo markers of anxiety in drug-naïve
Longitudinal Study with Optical Coherence Parkinson’s disease
Tomography H. Wilson, E. de Natale, M. Politis (University of
E. Pinkhardt, F. Euler, D. Batra, J. Kassubek (Ulm Exeter)
University)
652
621 Microstructural changes in GBA mutation
Resting State Functional and Structural carriers with depression
Connectivity Changes of Cerebellum Basal H. Wilson, E. de Natale, M. Politis (University of
Ganglia Interconnecting Network in Exeter)
Parkinson’s Disease
V. Radhakrishnan, S. Krishnan, B. Thomas, C. 654
Gallea, C. Kesavadas, A. Kishore (Sree Chitra Neural Correlates of Semantic Fluency Deficits
Tirunal Institute for Medical Sciences and in Parkinson’s Disease with Mild Cognitive
Technology) Impairment
J. Yang, G. Byrne, J. O'Sullivan, K. McMahon, D.
633 Copland, N. Dissanayaka (University of
Identifying neural signatures of Parkinson’s Queensland Centre for Clinical Research)
disease that predict decline in gait and postural
control 657
H. Sigurdsson, A. Yarnall, B. Galna, S. Lord, L. Effect of globus pallidus interna deep brain
Alcock, R. Morris, R. Lawson, S. Colloby, M. stimulation on functional connectivity in
Firbank, N. Pavese, D. Brooks, J. O'brien, D. Burn, patients with Parkinson’s disease
L. Rochester (Newcastle University) C.C. Zhang, N.Y. He, J. Li, Y.J. Lai, L.B. Wang,
B.M. Sun, V. Voon, F.H. Yan, D.Y. Li (Ruijin
635 Hospital, Shanghai Jiao Tong University School of
Alpha-synuclein preformed fibril (PFF)- Medicine)
triggered synucleinopathy recapitulates
neurochemical features of human PD: A PET 662
study in rats Unraveling neural oscillatory changes due to
C. Sortwell, J. Patterson, C. Kemp, K. Miller, A. STN Coordinated Reset Deep Brain Stimulation
Stoll, M. Duffy, K. Luk, V. Sossi (Michigan State in the MPTP Non-Human Primate Model of
University) Parkinsonism
J. Bore, B. Campbell, H. Cho, M. Newcomb, R.
645 Faulhammer, A. Machado, K. Baker (Lerner
Brain atrophy progression in de novo Research Institute, Cleveland Clinic)
Parkinson’s disease
C. Tremblay, S. Rahayel, A. Vo, A. Dagher 664
(Montreal Neurological Institute and Hospital) Asymmetrical cochlear dysfunction as a
lateralized non-motor feature in Parkinson’s
646 disease
Neuroimaging Extra-Striatal D2 Receptors in R. Cerroni, A. Viziano, R. Sisto, A. Moleti, N.B.
Parkinson’s Disease with Rapid Eye Movement Mercuri, A. Stefani, M. Pierantozzi (Parkinson
Sleep Behaviour Disorder Centre, Department of System Medicine, University
M. Valli, S.S. Cho, M. Masellis, R. Chen, Y. of Rome Tor Vergata)
Koshimori, M. Diez-Cirarda, A. Mihaescu, A.
Strafella (Centre for Addiction and Mental Health 671
(CAMH)) Rhythmic activity of subthalamic neurons
during externally and internally generated
648 movements in Parkinson's disease
Progression of cortical thinning in Parkinson’s V. Filyushkina, E. Belova, S. Usova, V. Popov, A.
disease Tomskiy, A. Sedov (N.N. Semenov Federal
A. Vo, C. Tremblay, S. Rahayel, Y. Yau, A. Dagher Research Center for Chemical Physics, Russian
(Montreal Neurological Institute) Academy of Science)673
Visual Motion Perception and Metacognition in
Parkinson's disease 710
O. Halperin, R. Karni, S. Israeli-Korn, S. Hassin- Effects of Long-Term Treatment with
Baer, A. Zaidel (Bar Ilan University) Fluvoxamine on Non-Motor Symptoms and
Neurogenesis in an Early Post-Natal Stress Rat
678 Model of Parkinson’s Disease
Lack of depotentiation may not be a hallmark of E. Dalle, W. Daniels, M. Mabandla (Universoty of
Levodopa-induced dyskinesias KwaZulu-Natal)
A. Kishore, P. James, S. Krishnan, K. Divya, S.
Meunier (Sree Chitra Tirunal Institute of Medical 729
Sciences and Technology) A study of gut microbiota dynamics in
Parkinsonian mice
681 E. Klann, M. Tagliamonte, M. Ukhanova, V. Mai, V.
Application of Deep Neuronal Networks for the Vedam-Mai (University of Florida)
extraction of spectral characteristics in patients
with Parkinson's disease 737
A. Maitin, A. Garcia-Tejedor, M. Castillo, I. Activated microglia contribute to MPTP-
Serrano, E. Rocon, A. Arroyo, J. Andreo, J. induced impairment of cardiovascular function
Romero (CEIEC - Universidad Francisco de X. Liu, B. Wei, Q. Sun, Q. Bi, X. Shen, P. Shi
Vitoria) (Zhejiang Hospital)
686 740
The Many Faces of Bradykinesia in Parkinson’s Depression in Parkinson’s Disease:
Disease : The Quantitative Analysis from A perspectives from an Australian cohort
Keyboard Typing Test M. Lubomski, R. Davis, C. Sue (Royal North Shore
P. Panyakaew, K. Duangjino, T. Ploensin, K. Hospital)
Piromsopa, R. Bhidayasiri (1Chulalongkorn Centre
of Excellence for Parkinson’s Disease and Related 766
Disorders, Department of Medicine, Faculty of Temporal characterization of motor,
Medicine, Chulalongkorn University and King gastrointestinal, and behavioral symptoms in a
Chulalongkorn Memorial Hospital) SNCA A53T transgenic mouse model of
Parkinson’s disease
687 N. Radisavljevic, M. Cirstea, K. Bauer, B. Finlay
Genetic Profiling of Early Synucleinopathy in (Michael Smith Laboratories, University of British
Rat Nigrostriatal Dopamine Neurons Columbia)
J. Patterson, C. Kemp, M. Duffy, J. Howe, C.
Russell, A. Stoll, K. Miller, J. Beck, S. Counts, K. 782
Steece-Collier, K. Luk, C. Sortwell (Michigan State Risk of Hospital Admission in Patients with
University) Parkinson's disease Associated Psychosis
(1991-2010)
694 C. Stang, M. Hajeb, E. Camerucci, P. Turcano, A.
Pain syndrome in Parkinson's disease: Mullan, P. Martin, V. Abler, M. Splett, N. Rashid, J.
neurophysiological and MRI morphometric Bower, M. Mielke, R. Savica (Mayo Clinic)
features
O. Alenikova, I. Goursky, N. Alenikov (Republican 800
Scientific and Clinical Center of Neurology and The role of the disorders in interaction between
Neurosurgery) visual and oculomotor systems and their MRI
correlation in patients with camtocormia in
700 Parkinson's disease
The role of dopamine mis-metabolism in O. Alenikova, S. Likhachev (Republican Scientific
preclinical Parkinson’s disease olfactory and Clinical Center of Neurology and
deficits Neurosurgery)
L. Beauchamp, L. Vella, A. Bush, K. Barnham (The
University of Melbourne)803
Disease progression characterized by motor
performance, dopaminergic neurodegeneration 821
and T cell infiltration in the transgenic hm2-α- A longitudinal study on alpha-synuclein in
SYN-39 mouse model of Parkinson´s disease plasma neuronal exosomes as a biomarker for
J. Behnke, L. Rauschenberger, S. Knorr, J. Parkinson's disease development and
Volkmann, C.W. Ip (University Hospital Wuerzburg) progression
M. Niu, Y. Li, G. Li, L. Zhou, N. Luo, M. Yao, W.
806 Kang, J. Liu (Ruijin Hospital Affiliated to Shanghai
The interaction of Parkin and TAF15 for the Jiaotong University School of Medicine)
Drosophila in which neuronal defect was
induced 825
E.J. Choi, D.G. Lee, C.C. Cui, K.Y. Kim An agent-based model replicates the
(Department of Neurology, Ulsan University pathogenic spread of alpha-synuclein in mice
Hospital, Ulsan University College of Medicine) S. Rahayel, B. Mišić, Y.Q. Zheng, Z.Q. Liu, A.
Caputo, K. Luk, A. Dagher (Montreal Neurological
807 Institute and Hospital, McGill University)
Characterization of striatal dopaminergic
neurotransmission in the rat pre-formed fibril 826
models of Parkinson’s disease Effectiveness of lead position with
I. Del Priore, N. Chambers, M. Coyle, R. Fassler, J. microelectrode recording based support vector
Patterson, C. Kemp, A. Stoll, K. Miller, K. Luk, C. machine for characterizing the sub-cortical-
Sortwell, C. Bishop (Binghamton University) structures via deep brain stimulus in
Parkinson`s disease
809 V. Rama Raju (CMRCET, Jawaharlal Nehru
Movement Disorders After Bariatric Surgeries – Technological University)
Case Series
G. Fabiani, C.H. Camargo, H. Teive (Hospital de 828
Clínicas, Federal University of Parana) Difference in distribution between alpha-
synuclein oligomers and Lewy bodies in
813 Parkinson’s disease brain
Selective α-synuclein overexpression-induced H. Sekiya, H. Kowa, Y. Hashimoto, M. Takata, R.
pathology in noradrenergic neurons: a new Matsumoto, T. Toda (Kobe University Graduate
mouse model for prodromal Parkinson’s School of Medicine)
disease?
B. Lee, Y. Chen, G. Ganjam, N. Decher, A. 829
Gundlfinger, WD.J. Berg, M. Britschgi, O. Oertel Spreading ɑ-synuclein pathology initiated from
(Philipps University Marburg) the sublaterodorsal tegmental nucleus models
RBD followed by Parkinsonian phenotypes in
814 mice
Biomarkers for Parkinson´s Disease with Reflex Y. Shen, W.B. Yu, B. Shen, H. Dong, J. Zhao, Y.
Tears Correlate with Disease Duration Fan, Y.F. Yang, Y.M. Sun, Y.L. Tang, F.T. Liu, J.J.
M. Lew, S. Janga, D. Feigenbaum, D. Freire, M. Wu, B.G. Xiao, H. Yu, J. Koprich, Z.L. Huang, J.
Edman, W. Mack, C. Okamoto, S. Hamm-Alvarez Wang (Huashan Hospital, Fudan University)
(USC/Keck School of Medicine)
833
815 Increased epinephrine in the saliva of
An objective comparison of forward and Parkinson’s disease patients: A preliminary
backward postural instability in early observation
Parkinson's disease P. Wichit, S. Thanprasertsuk, T. Hopetrungraung,
C. Lu, S. Amundsen Huffmaster, K. Louie, R. O. Phokaewvarangkul, S. Bongsebandhu-
McGovern, C. MacKinnon, S. Cooper, R. Lowe, J. phubhakdi, R. Bhidayasiri (Faculty of Medicine,
Vitek, R. Abulu (University of Minnesota) Chulalongkorn University)835 983
Alpha synuclein BAC transgenic mice as a Poly-ADP-ribose polymerase 1 modulates
preclinical model for disease-modifying mitochondrial fission via LRRK2 in a rotenone-
therapies in Parkinson's disease induced Parkinson's disease model
H. Yamakado, S. Okuda, T. Taguchi, M. Ikuno, M. L. Bu, Y. Lu, Y. Liang, Y. Chen, S. Peng (Sun Yat-
Uemura, N. Uemura, M. Hondo, M. Yanagisawa, Sen Memorial Hospital, Sun Yat-Sen University)
R. Takahashi (Kyoto University Graduate School of
medicine) 987
The add-on effect of Lactobacillus plantarum
864 PS128 in patients with Parkinson’s disease: A
Neural activity in the subthalamic nucleus in pilot study
association with reward/loss processing in H.C. Chang, Y.C. Tsai, C.S. Lu (Professor Lu
patients with Parkinson's disease Neurological Clinic)
C.C. Zhang, J. Li, L. Manssuer, Q. Ding, L.B.
Wang, B.M. Sun, D.Y. Li, V. Voon (Ruijin Hospital, 1014
Shanghai Jiao Tong University School of Medicine) Calcitriol Treatment Attenuates Dopaminergic
Neurodegeneration in Mice Model of
915 Parkinson’s Disease
Morphological changes of retina in patients J.J. Hu, T. Wang (Affiliated Union hospital of
with Parkinson's disease and the role of α- Huazhong University of Science & Technology,
synuclein in retinal damage Wuhan, China)
L. Man, Z. Wei (The First Affiliated Hospital of
Chengdu Medical College) 1017
Comparing the effects of rosemary and
927 selegiline on behavioral symptoms of
Serum microRNA expression levels in Turkish Parkinson’s animal model in mice
patients with Parkinson’s disease M. Modaresi (Isfahan (Khorasgan) Branch, Islamic
B. Ozdilek, B. Demircan (Department of Neurology, Azad University)
Istanbul Medeniyet University Faculty of Medicine)
1021
945 Blood hexokinase reduction in de novo
Phase I Study Design of a Leucine-Rich Repeat Parkinson’s disease and remodeling of
Kinase 2 (LRRK2) Antisense Oligonucleotide, glycolytic energy homeostasis with L-
for Parkinson's Disease DOPA/Istradefylline combination therapy
J. Shirvan (Biogen) N. Kanzato, K. Nakachi, S. Mochizuki, (Okinawa
Prefectural Southern Medical Center & Children’s
948 Medical Center)
NILO-PD: A Phase 2A Study of Nilotinib in
Patients with Moderately Advanced Parkinson’s 1022
Disease: Exploratory Efficacy Outcomes Ceftriaxone improves motor function in a rat
T. Simuni, C. Coffey, E. Klingner, C. Caspell- hemi-parkinsonian model: Potential to delay
Garcia, D.E. Lafontant, K. Merchant, B. Fiske, H. bilateral progression of motor deficits in
Matthews, R. Wyse, P. Brundin, D. Simon, M. Parkinson’s disease
Schwarzschild, D. Weiner, J. Adams, L. Trusso, L. E. Kasanga, C. McElroy, M. Salvatore (University
Baker, M. Kostrzebski, C. Venuto, G. Rafaloff, T. of North Texas Health Science Center)
Ward (Northwestern University Feinberg School of
Medicine) 1024
Anti-parkinson effect of natural L-DOPA
971 containing drug Mucuna pruriens against the
Andrograholide protect microglial activation via rotenone induced rat model of Parkinson's
inhibiting mitochondrial ROS generation and disease
NLRP3 inflammasome activation in in-vitro and V. Kumar, F. Anwar (Sam Higginbottom University
in-vivo model of Parkinson's disease of Agriculture, Technology & Sciences)
S. Ahmed, V. Naidu (Laboratory of Neuroscience,
National Institute of Pharmaceutical Education and
Research- Guwahati)1032 1076
Quantitative study of T-type Ca2+ channels in Identification and characterization of anti-
the subthalamic nucleus neurons towards prionic compounds that disassemble αSyn
Parkinson’s disease prions as a novel therapeutic approach for
C. Mahapatra (Indian Institute of Technology synucleinopathies
Bombay) D. Willbold, M. Sevenich, W. Hoyer, J. Mohrlüder,
A. Willuweit (Forschungszentrum Jülich)
1038
Comparison of the effect of hydroalcoholic 1080
extract of olive leaf and levodopa on reducing Automated classification of neurodegenerative
parkinson's symptoms in animal model parkinsonian syndromes using multimodal
M. Modaresi (Isfahan (Khorasgan) Branch, Islamic magnetic resonance imaging in a clinical
Azad University) setting
L. Chougar, J. Faouzi, N. Pyatigorskaya, O. Colliot,
1041 S. Lehéricy (Institut du cerveau et de la moelle,
New compound increasing glucocerebrosidase Sorbonne Université, Paris, France)
activity on primary cell cultures obtained from
patients with GBA-associated Parkinson’s 1084
disease Age and gender differences in cardiovascular
M. Nikolaev, A. Kopytova, K. Senkevich, G. autonomic failure in transgenic PLP-syn mouse
Baydakova, I. Miliukhina, E. Zakharova, G. model of multiple system atrophy
Rychkov, A. Cheblokov, F. Ibatullin, S. Pchelina, A. M. Kermorgant, D. Arvanitis, P.O. Fernagut, W.
Emelyanov (Petersburg Nuclear Physics Institute Meissner, J.M. Senard, C. Galès, A. Pavy-Le
named by B.P. Konstantinov of National Research Traon (Institut des Maladies Métaboliques et
Center «Kurchatov Institute») Cardiovasculaires)
1062 1086
Targeting the Receptor of Glial Cell Line- Sleep-related Symptoms in Multiple System
Derived Neurotrophic factor to treat Atrophy: Determinants and Impact on disease
Parkinson’s Disease severity
Y. Sidorova, A. Mahato, M. Saarma (University of J.Y. Lin, L.Y. Zhang, B. Cao, Q.Q. Wei, H.F. Shang
Helsinki) (West China Hospital, Sichuan University)
1063 1087
Characterization of novel alpha-synuclein CHCHD2 mRNA levels in erythrocyte are
aggregation model of Parkinson's disease reduced in patients with multiple system
A. Singh, S. Reunanen, A. Panhelainen, M. atrophy
Voutilainen (University of Helsinki) G.l. Liu, X.d. Liu, T. Feng (Beijing Tiantan Hospital,
Capital Medical University)
1064
Neuroprotective and neuromodulatory 1098
properties of Olea purpurea leaf extract in GCI-induced neurodegeneration and
MPTP intoxicated Parkinsonian rat model synucleinopathy in non-human primates
A. Singh, T. Yadav, A. Pandey (Department of M. Teil, S. Dovero, M.L. Artocarena, M. Bourdenx,
Biochemistry, University of Allahabad) G. Porras, B. Mollenhauer, M.T. Herrero, M. Vila, J.
Obeso, B. Dehay, E. Bezard (Institute of
1072 Neurodegenerative Diseases)
Effects of a next-generation neurotrophic
compound in a toxin model of Parkinson’s 1124
disease Temporhythmal Correction: The New Way of
T. Viljakainen, M. Saarma, M. Voutilainen (Institute Therapy and Diagnostic Secondary Vascular
of Biotechnology, University of Helsinki) Parkinsonism
D.T. Akramova (Tashkent Medical Academy)
1074
Distribution of intranasal hNSCs in a mouse
model of MPTP-induced Parkinson's disease
F. Wang, Y.T. Zhang, S.Z. Wei, C. Ren, C.F. Liu
(Institute of Neuroscience, Soochow University)1155
1130 Visuospatial training improved the visuospatial
The effect of comorbid NPH on the clinical abilities in child with cerebral palsy: case
feature and progression of Parkinson's disease report
A. Hattori, T. Tsunemi, Y. Ishiguro, N. Hattori S. Kiselev (Ural Federal University)
(Juntendo University School of Medicine)
1160
Inter-relation between hand functioning,
1132
cognition and quality of life of CP children: 2-
Development and validation of a profile of
year prospective randomized study
peripheral immune biomarkers for Parkinson’s
T. Voloshyn, V. Kozyavkin, L. Shestopalova
disease: A multicenter, retrospective study
(Kozyavkin Medical Rehabilitation Clinic)
Y. Li, J. Liu (Department of Neurology & Institute of
Neurology, Ruijin Hospital affiliated to Shanghai
Jiaotong University School of Medicine) 1176
Cortical Activation during Dynamic Sway of
young Fragile X Premutation Carriers
1134
C. O'Keeffe, M. Carro Domínguez, E. O'Rourke, T.
Microbiome from Parkinson’s patients shows
Lynch, T. Reilly (Trinity Centre for Bioengineering,
an increase in polyamines metabolism and
Trinity College Dublin)
differentially expresses microbial bacterial taxa
compared to aged-matched normal controls
1185
S. Melgar, N. Danso, C. Pena, J. Ahmed, S.
The Feasibility of Using of the Non-Medication
Kumar, R. Kumar, C. Carlin, D. Linseman, D.
in the Treatment of Post-Stroke Vascular
Paredes (Knoebel Institute for Healthy Aging,
Parkinsonism
University of Denver)
O. Tondiy, O. Zavalna (Kharkiv Medical Academy
of Postgraduate Education, Ukraine)
1136
Staircase sign for Atypical and Secondary
1187
parkinsonism
Challenge Point Guide: Characterizing
Y.S. Oh, J.S. Kim, D.Y. Kwon, M.H. Park, B.R.
exercises performed in multilevel Parkinson-
Bloem (College of Medicine, The Catholic
specific community exercise classes
University of Korea)
E. Borchers, J. Goodwin, J. Bazan-Wigle, T.
McIsaac, B. Farley (Parkinson Wellness Recovery)
1141
Intracranial Tuberculous Abcess with Acute
1221
Parkinsonism: Unusual Finding
Brain activity underpinning visual cues for gait
K.K. Shahedah, A. Nurul Asyikin (Faculty of
impairment in Parkinson’s disease
Medicine, International Islamic University
S. Stuart, J. Wagner, S. Makeig, M. Mancini
Malaysia(IIUM))
(Oregon Health and Science University)
1149
1242
Circadian rhythm alterations in an in vitro
Comparative analysis of the quality of life
cellular model of Spinocerebellar ataxia type 17
between healthy elderly people and those with
F. Motolese, A. Casamassa, A. Vescovi, V. Di
Parkinson’s disease
Lazzaro, J. Rosati, M. Marano (Università Campus
L. Santos, A. Alonso, N. Luna, J. Greve
Bio-Medico di Roma)
(Universidade Anhembi Morumbi)
1150
1257
Changes in the AKT/GSK3 pathway in the
A translational approach to determine target
cerebellum increase susceptibility to
concentrations of MIN-102 (leriglitazone) to
movement disorders in a rat model of post-
support a Phase II study in Friedreich’s ataxia
traumatic stress disorder
S. Poli, L. Rodríguez-Pascau, J. Ros, P. González-
G. Ngoupaye, M. Mabandla (College of health
Cabo, E. Britti, D. Lynch, G. Pina, S. Pascual, M.
Science, University of Kwazulu-Natal)
Cerrada-Gimenez, D. Eckland, E. Traver, J.
Wetering-de-Rooij, M. Martinell, U. Meya, P.
Pizcueta (MInoryx Therapeutics BE)1283 1365
Bruxism Associated with Restless Limbs Intraoperative test objectively for discovering
Syndrome (RLS): A Dopamine Responsive optimal electrode site for effective imaging (by
Movement Disorder eye) and bilateral STN-DBS stereotactic
D. Dickoff, S. Dontje, R. Sirkin, N. Ditkoff functional neurosurgery
(Metropolitan Neurological Consultants, PC) V. Rama Raju, L. Neerati, A. Dabbeta, H. Yeruva,
S. Konda, N. Guguloth (CMR College of
1294 Engineering & Technology (JNTUH) & NIMS
Neuronal Inclusion Formation and Axonal Hospital)
Degeneration in Mutant TFG Transgenic Mice
T. Kawarai, A. Orlacchio, R. Kaji (Institute of 1366
Biomedical Sciences, Tokushima University Objective study of intra operative test for
Graduate School) discovering optimal electrode site for effective
imaging and bilateral STN-DBS stereotactic
1295 functional neurosurgery
Heterozygous mutation in CCDC88C gene as a V. Ramaraju (CMR College of Engineering &
cause of early onset pure hereditary spastic Technology, and Nizam`s Institute of Medical
paraplegia Sciences (NIMS) Hospital)
A. Mohamed, S. Emad, R. Adil, L. Elsayed, A.
Ahmed, G. Stevanin (Faculty of Medicine, 1377
University of Khartoum) Neuropathological Changes Following PPN
Region DBS
1296 V. Vedam-Mai, A. Elkouzi, S. Prokop, A. Yachnis,
Transcutaneous spinal cord current stimulation K. Foote, L. Almeida, A. Ramirez-Zamora, M. Okun
modulate Reactive Oxygen Species (ROS) in (University of Florida)
multiple sclerosis patients
S. Mrakic-Sposta, R. Ferrucci, S. Floro, F. 1385
Ruggiero, M. Vergari, S. Versace, S. Santoni, A. Single-energy Metal Artefact Reduction: a
Vezzoli, M. Massei, M. Deriz, S. Marceglia, S. Precise Method for Localization of Deep Brain
Barbieri, A. Priori (National Research Council Unit - Stimulation Electrodes in Parkinson’s Patients
Institute of Clinical Physiology Milan- (CNR-IFC)) W. Xian, L. Chen, J. Liu, C. Yang (The First
Affiliated Hospital, Sun Yat-Sen University)
1299
New tool to localize seizure onset zone from 1386
sEEG signal-connectivity epileptogenicity Voltage Adjustment Effects More on Limb
index Symptoms than Axial Symptoms in Parkinson’s
A. Balatskaya (National Medical Surgery Center Disease Patients Treated with Subthalamic
named after Pirogov) Nucleus Stimulation
W. Xian, L. Chen, J. Liu, C. Yang (The First
1331 Affiliated Hospital, Sun Yat-Sen University)
Long-term effect of deep brain stimulation in a
monkey model of Parkinson’s disease with L- 1398
Dopa–induced dyskinesias Automated Capture of Deep Brain Stimulation
M. Bourque, S. Carrondo-Cottin, M. Parent, L. Settings & Clinical Outcomes
Cantin, B. Gosselin, M.E. Tremblay, T. Di Paolo K. Castell, C. Butson (University of Utah)
(CHU de Quebec-Université Laval)
1400
1346 Bioengineered nigrostriatal constructs model
Plasticity of frequency dependent tremor Lewy pathology
control in Parkinson disease (PD) subthalamic E. Clark, L. Struzyna, W. Gordián-Vélez, I. Chen,
nucleus (STN) deep brain stimulation (DBS) K. Cullen, J. Duda (Michael J. Crescenz VA
implanted individuals Medical Center)
E. Hargreaves, D. Schneider, R. DiPaola, J. Chen,
S. Danish, D. Caputo (Rutgers University -- Robert
Wood Johnson Medical School)1413 1458
Efficacy of a Vibrational Armband in Cerebellar structural covariance networks in
Maintenance of Forced Arm Swing in young people with Tourette syndrome
Parkinsonism H. Sigurdsson, S. Jackson, L. Jolley, E. Mitchell, G.
A. Harbour, J. VanWart, Z. Mercer, K. Pique, R. Jackson (University of Nottingham)
Golan, J. Clark, C. Maitland (FSU College of
Medicine) 1469
Can bedside neurophysiological testing aid the
1443 differential diagnosis of bilateral upper limb
The Unique Voiceprint Changed In Parkinson’s action tremors in young-onset patients?
Disease T. Dang, P. Panyakaew, R. Bhidayasiri
F. XU (Chengdu medical college)
1474
1444 Efficacy and safety of CX-8998 in T-CALM, a
The diagnostic value of smartphone-based randomized, double-blind, placebo-controlled,
instrumented Timed Up & Go test in different phase 2a trial in participants with essential
movement disorders tremor: subgroup analysis by baseline tremor
G. Yahalom, S. Israeli-Korn, T. Fay-Karmon, V. severity
Livneh, K. Tchelet, Z. Yekutieli, A. Stark-Inbar, S. H. Jinnah, S. Papapetropoulos, M. Lee, S.
Hassin-Baer, H. Yahalom, M. Linder (Shaare Versavel, E. Newbold, R. Pahwa, K. Lyons, R.
Zedek Medical Center) Elble, W. Ondo, T. Zesiewicz, P. Hedera, A.
Handforth, J. Elder, M. Versavel (Emory University
1448 School of Medicine)
A novel easily performed objective test of fine
motor skill in handwriting and drawing to 1482
support diagnosing Parkinson’s disease No frank biochemical evidence of
R. Zietsma, S. Bojic, A. Karki, R. Bauer, M. van proteinopathy in the cerebellar cortex of
Gils, L. Cluitmans, A. Tolonen, R. Walker, K. Gray patients with essential tremor
(Manus Neurodynamica Ltd) K. Melançon, A. Rajput, A. Rajput, C. Tremblay, F.
Calon, E. Aubry-Lafontaine, E. Brochu, S. Paris-
1449 Robidas (Centre de recherche du CHU de Québec
A C12orf65 mutation-related autosomal – Université Laval)
recessive hereditary spastic paraplegia is
associated with autophagy induction 1483
L. Wu, Y. Xu, Q. Wang, X. Lai, I. Vinnikov, W. Post mortem fatty acid abnormalities in the
Chen (Department of Neurology, Shanghai Ninth cerebellar cortex of patients with essential
People’s Hospital, Shanghai Jiao Tong University tremor
School of Medicine) K. Melançon, L. Berthiaume, C. Tremblay, P.
Juline, A. Rajput, A. Rajput, F. Calon (Université
1451 Laval)
Children with Tourette syndrome show greater
variability in an arm-position-matching 1487
proprioceptive task The pathophysiology of dystonic tremors and
N. Cothros, A. Medina, D. Martino, S. Dukelow, R. comparison with essential tremor
Hawe, A. Kirton, E. Nosratmirshekarlou, T. P. Panyakaew, H.J. Cho, S.W. Lee, M. Hallett
Pringsheim (University of Calgary) (Chulalongkorn Center of Excellence for
Parkinson’s Disease & Related Disorders,
1456 Department of Medicine, Faculty of Medicine,
Endocrine Predicts of the Formation of Chulalongkorn University and King Chulalongkorn
Complex Motor Tics in Tourette’s Disease Memorial Hospital, Thai Red Cross Society)
D. Labunskiy, E. Yurasova, N. Kurgaev, S.
Kiryukhina, V. Podsevatkin, D. Baranov (Neurology
and Psychiatry, N.P. Ogarev Mordovia State
University, Saransk, Russia)You can also read
