Research news 2020 2021 - Department of Computer Science

 
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Research news 2020 2021 - Department of Computer Science
Research news
2020 - 2021

Department of
Computer Science
Research news 2020 2021 - Department of Computer Science
Contents
                                      Research News                          16
                                                                             Video games evoke emotions that
                                      4                                      even music and cinema fail to reach
                                      What prevents us from making
                                      the most of the IoT? Aalto             17
                                      researchers developed ways             Artificial intelligence for
                                      to make IoT truly ubiquitous           dementia prevention

                                      5                                      18
                                      Finns’ use of data is growing          How did Runeberg’s career progress?
                                      rapidly and increasing electricity     AcademySampo helps find the
                                      consumption in the entire ICT sector   answer from a huge amount of data

                                      6                                      19
                                      Artificial intelligence produces       Alumna Juulia Suvilehto is studying
                                      data synthetically to help treat       how coronavirus is affecting
                                      diseases like COVID-19                 social behaviour and touching

                                      7                                      20
                                      Sleep apnea is a threat for            Artificial intelligence model developed
                                      public health - students               by Finnish researchers predicts
                                      developed an application that          which key of the immune system
                                      recognizes its signs at home           opens the locks of coronavirus

                                      8                                      21
                                      How vaping companies                   Will AI make us better humans?
                                      exploit Instagram for youth-           Why we must be cautious
                                      oriented marketing?
                                                                             22
                                      9                                      What archaeological objects have
                                      Practices identified at Terveyskylä    been found in different parts of
                                      for facilitating the adoption of       Finland? Researchers have developed
                                      online health care services            FindSampo to bring together the
                                                                             discoveries made by citizens
                                      10
                                      University collaboration brings        23
                                      a scope of new possibilities           AI predicts if storms will cause
                                      for Planmeca’s business                blackouts many days in advance

                                      11                                     23
                                      Scientists develop a sound device      Following e-cigarette conversations
                                      to allow monkeys living in a Finnish   on Twitter using artificial intelligence
                                      zoo to play sounds and music
Research news of 2020-2021 from
the Department of Computer Science                                           24
at Aalto University                   12                                     How is Instagram used by the leading
                                      New epidemic modelling facilitates     health agencies to engage with the
                                      assessment of corona strategies        public during the COVID-19 crisis?

Copyright © 2021 Aalto University     13
                                      Towards trustworthy AI and
                                      an autonomous Europe
Design and cover illustration:                                               Humans of Computer Science
Matti Ahlgren
                                      14                                     27
Published by Department of Computer   Pekka Marttinen: It is very
Science, Aalto University                                                    From her own little world to
                                      important to take good care of
                                                                             the other side of the globe
cs.aalto.fi                           health and social services data

                                      15                                     29
                                                                             Anna Cichonska uses data science
                                      AI predicts which drug
                                                                             to develop better healthcare
                                      combinations kill cancer cells
1
Research news 2020 2021 - Department of Computer Science
31                                     Computer Science News                   59
By studying software and                                                       ‘I’m happy I didn’t go anywhere
service engineering, you will          50                                      else’ – HAIC scholars very satisfied
learn truly useful skills              Ten new Academy projects awarded        with their studies at Aalto
                                       to the School of Science
33                                                                             61
Maarit Käpylä turned her               51                                      Forbes AI Award to research on
childhood hobbies into a living        Aalto students help develop digital     image-creating GAN models
                                       services for women’s charities
35                                     and family support groups               62
Besides coders, computer                                                       School of Science announced
science needs professionals            52                                      2021 equality implementation
interested in humans                   Flexibility and enthusiastic            plan, and funds new diversity
                                       teaching make the SECCLO                and inclusivity projects
37                                     programme a great option
Everyday choices: Nitin Sawhney, how                                           62
do we cooperate in times of crisis?    53                                    From Mars to machine learning
                                       The coronavirus pandemic encouraged
39                                     hundreds of experienced professionals 63
Meet the data agent: Richard Darst     to study change leadership            ‘For many people, it’s always
                                                                             been a crisis’ – a new Aalto
40                                     54                                    collective engages intersecting
Meet the data agent: Enrico Glerean    Nitin Sawhney receives an Academy     dimensions of crises
                                       of Finland grant for analyzing and
41                                     reconstructing crisis narratives      64
Tuomas Sandholm applies game                                                 Alumnus Kyunghyun Cho wants
theory in his companies and            54                                    to support women who study data
encourages everyone to study AI        Digital humanities information        science and artificial intelligence
                                       infrastructures receive the Academy
43                                     of Finland’s roadmap status           65
Former Nokia executive Tero Ojanperä                                         Career course gathered a diverse
believes intelligent platforms could   55                                    range of views, alumni and students
be next success story for Finland      ELLIS inaugurates 30 research units   around user experience
                                       at leading institutions across Europe
44                                                                             67
‘The atmosphere at Aalto is            55                                      CS S4 Student Symposium served
comfortable and you can do             European Commission grants              remote pizza, socializing and
things at your own pace’               €4M funding for SECCLO –                interesting discussions on AI
                                       Master’s Programme in Security
45                                     and Cloud Computing                     67
If you study computer science,                                                 Samuel Kaski receives major
you may end up developing better       56                                      international funding for the
cancer treatments by applying AI       CodeRefinery went online and            development of AI methods
                                       attracted over a hundred participants
47                                     from all over the Nordics               68
Teaching creativity to computers                                               Assistant Professor in Machine
- Christian Guckelsberger wants        57                                      Learning Arno Solin nominated
to equip AI with the motivation        Mario Di Francesco elected Computer     for Young Academy Finland
to discover the unexpected             Science teacher of the year 2020
                                                                               69
48                                     57                                      Follow Computer Science
Alexandru Paler: Creating software     SCI Awards 2020 celebrate our           research in Aalto University
for quantum computers                  successes in a challenging year
                                                                               70
                                       58                                      Kahvit näppikselle
                                       Doctoral thesis: Technology that’s
                                       better at detecting hate speech
                                       may also increase security risks

                                                                                                                      2
Research news 2020 2021 - Department of Computer Science
Research
   News

3
Research news 2020 2021 - Department of Computer Science
Research News

What prevents us from making the most of the IoT? Aalto
researchers developed ways to make IoT truly ubiquitous
For his doctoral dissertation, Óscar Novo Díaz researched the technical challenges
that prevent us from using the full potential of the Internet of Things
Research & Studies, published: 27.5.2020

  In recent years, the Internet of          ty, management, and data processing.       implementing a system designed to
Things (IoT) has become a reality in        Many of those challenges are scattered     enable interoperability across hetero-
our society. It has helped automatize       across the various layers of the Inter-    geneous semantic IoT domains.
our homes, healthcare, and industrial       net protocol stack, making it difficult      Due to the COVID-19 pandemic, Ós-
manufacturing, to mention just a few        to identify the crucial mechanisms         car Novo’s public defence took place
application areas. In the home envi-        contributing to the cause.                 online. He was physically together in
ronment, this can mean that your en-          As an important part of his doctor-      the same lecture hall with the kustos,
ergy supplier reads your energy meter       al research work, Óscar Novo and his       Professor Antti Ylä-Jääski, and the
automatically, or that you have a se-       colleagues developed several solutions     opponent, Professor Sasu Tarkoma,
curity system in your home, which al-       that address these problems. Particu-      but everyone else followed the con-
lows you to monitor and manage your         larly, the researchers implemented an      ference over Zoom. Novo thinks that
property, simply by using a mobile app.     IP-agnostic mechanism that enables         everything went well and having the
  Óscar Novo Díaz, Doctor of Science                                                   conference online had its benefits.
(in Technology) who recently graduat-                                                  ‘Normally, public defences are quite
ed from Aalto University, says that IoT                                                heavy and some people may be more
can be seen as an extension of the In-                                                 interested in the presentation, while
ternet, and one of its most essential as-                                              others want to hear the discussion
pects resides in its ubiquitous nature.                                                with the opponent. Now, people could
IoT devices are broadly available and             “Right now, we have pro-             just join and leave the conference
fully connected to each other and the              tocols for the Internet of          whenever they wanted.’
Internet.                                        Things, but we have to en-              Professor Ylä-Jääski kept track of
  However, one of IoT’s main challeng-             sure that all those proto-          the number of participants during the
es, too, lies in its ubiquitous nature;          cols – in terms of security,          event and he told Novo that, at some
currently some technical challenges                  accessibility, and so on          point, around 20–30 people were fol-
prevent us from making the most of                – are totally invisible and          lowing it online. ‘That felt really nice.’
IoT’s potential. Óscar Novo recently                   work very smoothly“               Óscar Novo has been working on the
defended his doctoral dissertation on                                                  IoT field for years, for which reason it
this topic, and he focused on four spe-                                                felt natural to select it as his disserta-
cific categories; ubiquitous commu-                                                    tion topic, too. Currently, he is working
nication, access control, concurrency                                                  as a researcher at a private company. ‘I
control, and ubiquitous semantics.                                                     would like to move towards another
  ‘Right now, we have protocols for                                                    research topic but still stay connect-
the Internet of Things, but we have                                                    ed to IoT and use my IoT knowledge.
to ensure that all those protocols – in     the connectivity and communication         For example, artificial intelligence is a
terms of security, accessibility, and so    of IoT devices behind Network Ad-          very promising and interesting area of
on – are totally invisible and work very    dress Translations. Moreover, they         research.’
smoothly, without spending too many         designed and implemented a resource          Óscar Novo Díaz defended his disser-
resources of the constrained IoT de-        concurrency framework to manage the        tation on 24 April 2020. The title of his
vices,’ he explains. By the term con-       concurrent access of shared resources      dissertation is ‘Improving the Ubiq-
strained, he means that inexpensive         in IoT environments.                       uitous Capabilities of the Internet of
devices, such as small sensors, run           To improve the current access con-       Things’.
on batteries and have a relatively low      trol situation, they also designed a
computation power.                          decentralized access control manage-
  The decentralization of IoT, its het-     ment system that relies on blockchain
erogeneity in terms of protocols, tech-     technology to control the authoriza-
nologies and standards, has created         tion policy of the IoT devices. Finally,
several interoperability questions          they addressed the problem of seman-
from the perspective of connectivi-         tic interoperability, proposing and        By Anu Haapala

                                                                                                                               4
Research news 2020 2021 - Department of Computer Science
Research News

Finns’ use of data is growing rapidly and increasing
electricity consumption in the entire ICT sector
The use of mobile data is growing fast in Finland, compared to other countries, re-
veals a recent report.
Research, published: 8.6.2020

  IP traffic and data use by the indus-     try. Consumers’ use of data services,      creasingly significant part of Finland’s
try and consumers have increased sig-       streaming services in particular, is       electricity consumption. While elec-
nificantly in the last fifteen years. In    a factor that has increased IP traffic     tricity in Finland is a relatively pure
Finland, the use of fixed data grew sev-    most significantly.                        form of energy, other energy sources
en-fold and the use of mobile data 25-        As states, companies and different       in the ICT industry should also be set
fold during 2011–2017. In the last few      types of organisations seek a shift to-    on a sustainable basis. During a power
years, the growth has slowed down,          wards a low-carbon economy, the role       cut, for example, reserve power comes
but researchers believe that the use        of the ICT sector is divided. On the one   from heat and fuels based on fossil fu-
of fixed and mobile data will keep on       hand, it has been proposed that the ICT    els that strain the environment,’ notes
growing in the coming years.                sector would seek more efficient ener-     Timo Seppälä, Chief Research Scien-
  The information is revealed by a re-      gy consumption and form a basis for a      tist at Etla and Professor of Practice at
cent report by Aalto University and         greener economy. On the other hand,        Aalto University.
ETLA Economic Research (Etla),              the growth in the ICT sector’s energy        ‘Research shows that despite the
which was released on Monday, 8             use and massive use of rare metals in      strong growth of IP traffic and the
June. In their report, researchers at       usable devices has been perceived as a     amount of data the electricity con-
Aalto and Etla address how the energy       threat to sustainable development.         sumption has not increased at an
and electricity consumption in the ICT                                                 equivalent rate. Instead the relative
sector increased during 2011–2017.                                                     share of the ICT sector’s electricity
  In the last decade, the information                                                  consumption of the total electricity
sector and software-based applica-                                                     consumption in European countries
tions acquired an increasing role in the             “In Finland, electricity          seems to be strongly linked to the num-
everyday lives of humans and organi-               consumption represents              ber of data centers. In other words, in
sations. Digital services, mobile appli-            as much as 68.7 per cent           the light of the information that was
cations and software are increasingly               of the energy consump-             gathered, the growth in electricity con-
utilised in everyday communication as                  tion in the entire ICT          sumption in the ICT sector is strongly
well as companies’ operations.                                        sector”          focused on data centers, not so much
  In Finland, the use of mobile data                                                   on telecommunications networks,’
alone increased on average 72 per cent                                                 says Kari Hiekkanen, Research Fel-
each year in 2011-2017. The share of                                                   low at Aalto University.
total data use in Finland is currently at                                                The researchers were able to form a
approximately 29 per cent. Its share in       In Finland, electricity consumption      good overview of the energy and elec-
relation to fixed network data is grow-     represents as much as 68.7 per cent of     tricity consumption in the ICT sector
ing more rapidly than in the countries      the energy consumption in the entire       using open data from Statistics Fin-
under comparison. The phenomenon            ICT sector. In 2011-2017, electrici-       land and Eurostat. Since open statis-
is explained by two factors: the avail-     ty consumption of the ICT sector in-       tical data was available in great extent
ability of fixed-price subscriptions        creased a total of 2.2 per cent annual-    in Finland as well as elsewhere in Eu-
with limitless data as well as Finland’s    ly. Within the ICT sector, the growth      rope, they were also able to compare
strong role as a developer of mobile        has been particularly strong in data       European countries.
technologies.                               processing where the electricity con-        The report has been written as part
  The increasing use of mobile data         sumption increased by 130.9 per cent.      of the Finnish Innovation Fund Si-
among consumers has not, however,           Data processing services include for       tra’s theme of carbon-neutral circular
resulted in growing household elec-         example data centres, the number of        economy and the Digital Disruption
tricity consumption but as increased        which keeps on increasing in Finland.      of Industry research project, which is
energy consumption in the entire ICT        In 2017, the share of the ICT sector in    funded by the Academy of Finland.
sector. Watching videos on the phone,       Finland’s entire electricity consump-
in other words, does not increase the       tion totalled one per cent.
electricity consumption of just a sin-        ‘The energy and electricity consump-
gle consumer but the entire ICT indus-      tion in the ICT sector will form an in-    By Anu Haapala

5
Research news 2020 2021 - Department of Computer Science
Research News

Artificial intelligence produces data synthetically to help
treat diseases like COVID-19
The ability to produce data synthetically makes studying of the COVID-19 disease
significantly easier.
Research, published: 25.6.2020

  Data driven technologies and ‘big         veal trade secrets and inventions to      er functionality. ‘There are still many
data’ are revolutionizing many indus-       their competitors. This is especially     things we don’t know about the new
tries. However, in many areas of re-        true in drug development, which re-       coronavirus: for example, we do not
search – including health and drug          quires lots of financial risk. If phar-   know well enough what the virus caus-
development – there is too little data      maceutical companies could share          es in the body and what the actual risk
available due to its sensitive nature       their data with other companies and       factors are. When researchers have
and the strict protection of individ-       researchers without disclosing their      synthetic data, we start understanding
uals. When data are scarce, the con-        own inventions, everyone would ben-       these things better,’ says Kaski.
clusions and predictions made by re-        efit.                                       FCAI researchers are now working
searchers remain uncertain, and the           The ability to produce data synthet-    on a project in which they use syn-
coronavirus outbreak is one of these                                                  thetic data to construct a model that,
situations.                                                                           based on certain biomarkers, predicts
  ‘When a person gets sick, of course,                                                whether a test subject’s coronavirus
they want to get the best possible care.                                              test is positive or negative. Biomark-
Then it would be important to have the                   “I myself would not          ers can be for example certain types of
best possible methods of personalized                  like to give insurance         molecules, cells, or hormones that in-
healthcare available,’ says Samuel                        companies my own            dicate a disease.
Kaski, Academy Professor and the Di-                  genomic information”              ‘The original data set with which we
rector of the Finnish Center for Artifi-                                              do this has been publicly available.
cial Intelligence FCAI.
  However, developing such methods
of personalized healthcare requires a
lot of data, which is difficult to obtain
because of ethical and privacy issues       ically solves these problems. In their
surrounding the large-scale gathering       previous study, which is currently be-            “To solve this issue, re-
of personal data. ‘For example, I my-       ing peer-reviewed, FCAI researchers               searchers at FCAI have
self would not like to give insurance       found that synthetic data can be used          developed a new machine
companies my own genomic informa-           to draw as reliable statistical conclu-           learning-based method
tion, unless I can decide very precisely    sions as the original data. It allows          that can produce research
what the insurance company will do          researchers to conduct an indefinite                  data synthetically”
with the information,’ says Professor       number of analyses while keeping the
Kaski.                                      privacy of the individuals involved in
  To solve this issue, researchers at       the original experiment secure.
FCAI have developed a new machine             The application that was published
learning-based method that can pro-         at the end of June works like this: The
duce research data synthetically. The       researcher enters the original data set
method can be useful in helping de-         into the application, from which the      Now we are trying to reproduce the re-
velop better treatments and to under-       application builds the synthetic data-    sults of the original research with the
stand the COVID-19 disease, as well as      set. They can then share their data to    help of synthetic data and build a pre-
in other applications. The researchers      other researchers and companies in a      dictive model from the synthetic data
recently released an application based      secure way.                               that was achieved in the original re-
on the method that allows academics           The application was released on the     search,’ explains Joonas Jälkö, doctor-
and companies to share data with each       fastest possible schedule so that re-     al researcher at Aalto University.
other without compromising the pri-         searchers investigating the Coronavi-      The research conducted at FCAI is
vacy of the individuals involved in the     rus pandemic would have access to it      funded by the Academy of Finland.
study.                                      as early as possible. Researchers are
  Many industries want to protect           further improving the application,
their own data so that they do not re-      to make it easier to use and add oth-     By Anu Haapala

                                                                                                                           6
Research news 2020 2021 - Department of Computer Science
Research News

Sleep apnea is a threat for public health - students
developed an application that recognizes its signs at home
The app is currently being tested, and its usability and
reliability will be improved based on test users’ feedback.
Research, published: 2.7.2020

  Sleep apnea is a very common sleep       er’s snoring through a microphone and     forming a home recording, it is not
disorder characterised by breathing        the sleeping position using the sen-      possible to control that the user per-
pauses and periodic snoring. Accord-       sors of a smartphone or smartwatch.       forms the measurement under optimal
ing to some studies, as much as ten        The most common clinical form of          conditions. The accuracy of the apnea
percent of the population suffer from      mild and moderate sleep apnea is po-      alerts has not been yet studied. Fortu-
it, but up to nine out of ten cases re-    sition-dependent; the apneas occur        nately, the application makes it easy to
main undiagnosed because symptoms          mainly when sleeping on the back. If      make repeated measurements, which
are sometimes mild and there are a                                                   compensates for the situation and in-
lack of resources in diagnostics. As un-                                             creases the reliability of the results,’
treated apnea can cause severe health                                                says Joni Gardemeister, one of the de-
issues, having simple and inexpensive               “Nine out of ten cases           velopers.
ways to monitor and screen the dis-                  remain undiagnosed                In the morning, the app forms an
ease would be important.                           because symptoms are              overall result of the night’s events, giv-
  To solve this issue, Finnish computer         sometimes mild and there             ing an idea of the amount of snoring
science students designed an Android             are a lack of resources in          and the number of breathing pauses
application, which helps to identify                           diagnostics”          in different positions. The results are
the signs of sleep apnea at home. Joni                                               saved in the application, making it easy
Gardemeister, Jonatan von Martens                                                    to track them over a longer period.
and Sowrov Doha, who study artificial                                                  SnoreTracker is based entirely on
intelligence, machine learning and                                                   the features of an Android smart de-
data science at Aalto University, devel-                                             vice; hence, the user does not need any
oped the app in collaboration with Dr.     breathing pauses occur while the user     additional devices. The app is suitable
Tapani Salmi, a medical doctor, PhD,       is sleeping on their back, the applica-   for anyone who suspects they may be
and specialist in Clinical Neurophysi-     tion detects the situation and alerts     suffering from the symptoms of sleep
ology and Sleep Medicine.                  the sleeper to change position.           apnea, or who simply wants to follow
  The SnoreTracker application, de-          ‘Sensors on smart devices are sensi-    their sleep. ‘It allows you to examine
veloped by the team, monitors the us-      tive and reliable. However, when per-     your own snoring, pauses in breathing

7
Research news 2020 2021 - Department of Computer Science
Research News

and sleeping at home on a low thresh-
old – even if you have no opportunity       How vaping companies exploit
for actual medical sleep study,’ Garde-
meister adds.
                                            Instagram for youth-oriented
  Diagnosing sleep apnea requires a         marketing?
polysomnography, usually performed          Researchers use artificial intelligence to analyse hun-
only during one night, either at home       dreds of thousands of Instagram posts about vaping
or in a hospital sleep laboratory. Mea-
suring is laborious and expensive, and      Research, published: 13.7.2020
in some countries, there are hardly
any resources for making such mea-
surements. For these reasons, the app         E-cigarettes are highly addictive nicotine products with unclear health impacts,
can be of significant help, as it makes     particularly on youth. Instagram is a visual social media platform which is wildly
it possible to monitor the sleep easily     popular among adolescents. Researchers interested in public health at Aalto Uni-
at home.                                    versity in Finland studied how vaping is represented on the platform. By using ar-
  If someone suspects they have sleep       tificial intelligence, they were able to analyse hundreds of thousands of posts from
apnea, they should however always           a 6-month period last year, and found that a large portion of posts are promoting
contact health care as well. Untreated      controversial flavoured e-liquids to young audiences.
sleep apnea can cause daytime somno-          The research analyzed Instagram posts shared between June to November 2019
lence, make the person more suscepti-       with a caption “#vaping”. ‘We knew this would be predominantly promotional
ble to accidents but also cause serious     material,’ said Dr. Aqdas Malik from the Department of Computer Science who
health risks. It increases the risk of      studies social media and user behaviors with a specific interest in online discourse
health problems such as hypertension,       about public health ‘but we were interested in what types of images these would
cardiac and neurological diseases.          be, and who was posting them.’ In the end, the research team generated a database
  Sleep apnea is most common in peo-        of over half a million pictures, which were sorted using a neural network, and sub-
ple middle aged and over, and obesity       sequently grouped the images into categories representing similar features.
is the major risk factor. As popula-          What the neural network
tions age and levels of obesity increase    showed was that over 40%
in countries with poor resources for        of the images – the larg-                   “By using artificial intelligence,
sleep medicine, there is a risk of a        est proportion out of the 6                    they were able to analyse hun-
sleep apnea epidemic, says Dr. Tapani       categories – were of e-liq-                dreds of thousands of posts from
Salmi.                                      uids or e-juices. These were                  a 6-month period last year, and
  The application is based on years         predominantly posted by                   found that a large portion of posts
of research work aimed at identify-         Instagram profiles listed                   are promoting controversial fla-
ing breathing disorders and develop-        as business accounts. The                    voured e-liquids to young audi-
ing algorithms and led by Dr. Salmi.        prominence of posts about                                                   ences.”
The accuracy of the methods has been        e-liquids is interesting from
studied at Helsinki University Cen-         a public health perspective
tral Hospital and the results have been     because, although many
published in the United States in the       e-cigarette brands market themselves as “smoking cessation” devices, it has been
Journal of Clinical Sleep Medicine,         shown by other studies that flavoured liquids are strongly linked to adolescent
Salmi says. ‘I suppose SnoreTracker         users taking up vaping in the first place. The USA banned the sale of flavoured
is the first project that helps monitor     liquids at the beginning of this year specifically to help tackle the huge growth of
and treat a disease this common with        teenage vaping, and other countries are looking to do the same.
the use of a mobile device,’ he notes.        ‘While print and broadcast media has clear rules and regulations about what can
  The developers emphasize that             and cannot be advertised, and what constitutes advertising, we don’t see this on
SnoreTracker is not a medical de-           social media,’ said Dr. Malik. ‘I believe we need stricter laws to regulate the visi-
vice but an application that promotes       bility of various substances - including vaping products on these networks. Any
health, sleep and well-being. Howev-        12-year-old with a phone can easily create a social media account and bypass the
er, with the help of feedback collected     age-rules for seeing what’s posted there, and the potential health implications are
from users, its usability and reliability   significant.’ 60% of all the posts using the hashtag #vaping were from business ac-
can be improved and developed. Peo-         counts. Over 70% of Instagram users are under 35, and over 35% of its users are
ple interested in the app can present-      under 24 years old. ‘It’s a huge grey area in terms of advertising regulations, espe-
ly download the beta version for free       cially regarding promotion towards younger audiences’ Dr. Malik said.
from Google Play app store.                   The research has been published in the International Journal of Medical Infor-
                                            matics, and is available to read online.

By Anu Haapala,
Illustration Matti Ahlgren                  By Anu Haapala

                                                                                                                               8
Research news 2020 2021 - Department of Computer Science
Research News

Practices identified at Terveyskylä for facilitating
the adoption of online health care services
It is important to involve professionals in the fields
of information technology and health care as well as
patients in the development of services

Research, published: 19.8.2020

  The adoption of online health care        on usability in the design process. In-     sponsibility of just one person within
services has been found very difficult      volving patients, which is often con-       an organisation.
globally: an estimated 45 per cent of       sidered a difficult feat, is also import-     ‘Professionals are motivated by ser-
services fail on account of resistance      ant.                                        vices that make it easier to work – for
from health care professionals. In a          ‘If we can involve even the small-        example, having to enter data only
study by Aalto University and Ter-          est group for testing, for example, the     once – as well as help patients. Accord-
veyskylä that has just been published,      feedback will help us to improve the        ing to the interviewees, interest has
numerous factors for facilitating the       usability of services. It would also        been shown towards a digital care path
adoption of the services have been dis-     useful to include professionals of us-      that helps to identify a serious skin
covered. The information will help in       er-centered design or service design.       symptom from home with the help of
launching new online health care ser-       They can identify hidden needs that         the patient sending a photograph,’ Ku-
vices in the future.                        the users are unable to report as well      jala says.
  The study focused on the Terveys-         as combine the needs of the different         Researchers have known for a long
kylä.fi online service used within spe-                                                 time that motivating health care pro-
cialised Finnish private health care to                                                 fessionals as well as patients to use
offers health care related information                                                  new online health care services is dif-
and support for citizens, along with                  “It is necessary to rec-          ficult. ‘The introduction of new digital
tools for health care professionals. In                 ognise that adopting            services causes stress in a hectic care
addition to virtual houses focusing on               services takes time and            work environment, and professionals
different health issues, accessible to                            resources”            have not always received enough sup-
everyone, Terveyskylä includes digital                                                  port in the change.’
care paths for certain patient groups.                                                    Yet digital services do, when func-
‘Since there are new digital care paths                                                 tioning properly, help to offer better
on the way, we wanted to gather les-                                                    services and support for profession-
sons from the first care paths to bene-     parties into solutions. Patients can be     als in their work. Services also cost
fit the later ones,’ says Research Fellow   included as part of the treatment on        Finland a great deal. Therefore, it is
and the first writer of the article Sari    a continuous basis on a small scale,        important to get professionals as well
Kujala.                                     but also in collaboration with patient      as patients to use them. Doctors and
  The researchers interviewed em-           organisations, thesis workers and re-       nurses do not always remember to
ployees of the university hospitals of      searchers,’ Kujala says.                    communicate about the services to
Helsinki, Turku, Oulu, Tampere and            The study also states that services       their patients. According to Kujala,
Kuopio, inquiring after their experi-       and changes related to them must be         this would be important: according to
ences regarding the adoption of ser-        communicated continuously. Ade-             research, having a professional recom-
vices. The interviewees were mainly         quate training must be provided to          mend services to their patients has a
nurses responsible for the adoption of      professionals, along with guidance on       huge impact on the use of the services.
the digital care paths in their place of    how to use the services, and any con-         The study is a part of the DigiIN proj-
work. They were selected among dif-         cerns they raise must be taken seri-        ect, which seeks to get all people in-
ferent care paths and different hospi-      ously. User feedback should also be         volved in a digital society by renewing
tals for the purpose of gathering les-      collected and the services tested at all    the service culture. The study is fund-
sons from a range of environments.          stages in order to enable continuous        ed by the Strategic Research Coun-
  Based on the results they gathered,       improvement of the services and to en-      cil (SRC). The research article was
the researchers conclude that when          sure that everyone can understand the       recently published in the Journal of
new digital services are introduced in      services. It is necessary to recognise      Medical Internet Research.
health care, it is essential to include     that adopting services takes time and
professionals of health care and infor-     resources. This is why the adoption
mation technology as well as experts        should be planned well and not the re-      By Anu Haapala

9
Research News

University collaboration brings a scope of
new possibilities for Planmeca’s business
Comparison of the model segmentation and the ground truth, from
the secondary test data annotations, for a CBCT scan. For further
explanation, see the research article in Nature Scientific Reports.

Research, published: 2.11.2020

  Collaboration between the Finn-           and make their work faster and more       meca.
ish Center for Artificial Intelligence      efficient, allowing them to focus on        The new deep learning method is
FCAI, dental equipment manufactur-          more challenging cases,’ says Profes-     based on the training of deep neural
er Planmeca and Tampere University          sor Kimmo Kaski from Aalto Univer-        networks with a dataset consisting of
Hospital (TAYS) will soon make the          sity.                                     3D cone beam CT (CBCT) scans. The
work of radiologists, mouth and jaw           Planmeca is one of the world’s lead-    research results were published in the
surgeons and dentists easier, in addi-      ing companies when it comes to man-       prestigious Nature Scientific Reports
tion to making the treatment of mouth       ufacturing dental equipment. For          publication in spring 2020.
illnesses even safer.                       Planmeca, the collaboration means           Based on the results, the model can
  Together with experts from Plan-          new and significant business opportu-     effectively identify designated struc-
meca and TAYS, researchers at FCAI          nities. The company plans to include a    tures in images. The method located
have developed a method to help lo-         new feature in its existing software to   mandibular canals on a detailed level
cate the nerve canal of the lower jaw,      ensure that the method will be used by    and was able to beat statistical shape
i.e. mandibular canal. This facilitates     healthcare professionals.                 models, which have previously been
the placement of teeth implants, for          Vesa Mattila, Senior Advisor of         determined as the best automated
example. A dentist placing a tooth im-                                                method of locating mandibular canals.
plant must know the exact location of                                                   It was important for Planmeca that
the mandibular canal in order to plan                “The new method will             the collaboration involved FCAI, Aal-
the size and position of the implant                be a tool for healthcare          to University and Tampere Univer-
and the entire procedure.                           professionals, not their          sity Hospital. Scientific publications
  Specialised dentist Jorma Järnst-                            replacement”           are almost indispensable to verify the
edt from Tampere University Hospi-                                                    functionality of the method and gain
tal specialises in radiology and den-                                                 research status. This and the collabo-
tal, oral and maxillofacial diseases. He    Medical Imaging at Planmeca Group,        ration with Tampere University Hos-
reveals that for a hospital radiologist,    has also followed the project with in-    pital helped to gain patient data for re-
locating the nerve canal is a routine       terest. He highlights that the entire     search purposes, which is essential in
procedure that must be done for each        collaboration began with the needs of     this type of study.
patient.                                    professionals of clinical work. ‘At the     Vesa Mattila points out that because
  Normally the task is very time-con-       time, the project had a great chance of   the field of dental care has moved
suming, and automating it reliably          succeeding, not just technically and      into 3D imaging, the amount of data
with the help of artificial intelligence    operationally, but also commercially.’    has jumped significantly. At the same
makes the work of healthcare profes-                                                  time, there is a need for more radiol-
sionals faster and easier, in addition      “The industry needs tools                 ogists. ‘Thus the industry needs tools
to making the treatment safer. ‘An al-      such as this one”                         such as this one.’
gorithm that is medically proven to                                                     All parties are grateful for their col-
be reliable makes the patient’s treat-        Artificial intelligence methods have    laboration partners. Although collab-
ment safe while reducing unpleasant,        taken significant leaps in the last       oration with instances from different
although very rare, surgical injuries,’     years. As for Planmeca, the company       fields is always challenging at first,
Järnstedt says.                             has for long been developing technol-     initial problems were quickly over-
  The benefit of artificial intelligence    ogy that is important for the company,    come. ‘In the initial stage, it felt like we
is that it does the work accurately ev-     3D X-ray imaging. ‘3D imaging is the      weren’t speaking the same language,
ery time. The new method will be a          pillar of our business, and we want to    but we are now. This is very important
tool for healthcare professionals, not      utilise it and commercialise the prod-    for the project,’ Mattila says.
their replacement. ‘The goal of the re-     ucts that have been created using it,’
search work is not to replace radiolo-      says Vesa Varjonen, Vice President
gists but to create a tool to assist them   of Research and Technology at Plan-       By Anu Haapala

                                                                                                                              10
Research News

Scientists develop a sound device to allow monkeys living in
a Finnish zoo to play sounds and music
The use of sounds is a promising way to improve
the life and wellbeing of animals living in captivity
Research, published: 7.10.2020

  Sound is a promising way to stim-        the sound system regularly throughout        toral researcher at Aalto University,
ulate zoo animals and increase their       the study and, after the first few days,     says that the result was both unex-
welfare, as shown by a study from          also began to sleep, groom, and so-          pected and expected. ‘I’ve been work-
Aalto University collaborating with        cialize with other monkeys inside the        ing with animals for a long time and
Helsinki’s Korkeasaari Zoo. Research-      sound device.                                learned to keep an open mind. Howev-
ers built a device that plays different      Kirsi Pynnönen-Oudman, re-                 er, given that the sound of traffic is so
sounds for a group of white-faced saki     search coordinator at Korkeasaari            unfamiliar to the sakis and not related
monkeys to listen to in their enclosure.   Zoo, says that food is often used to         to their normal daily life -- unlike, for
They were interested in the saki mon-      enrich the lives of animals in zoos.         example, the sound of rain -- it came as
key’s behaviour: did they want to use      However, non-food stimuli must also          a surprise that they were interested in
the device, when would they use it, and    be provided, especially for small an-        those sounds.’
what would they choose to listen to?       imals that are prone to gain weight.           According to Dr. Hirskyj-Douglas,
  Little is known so far about the sound   ‘Sounds are really important to many         the result suggests that scientists need
preferences of primates, so the re-                                                     to think carefully about what tech-
searchers wanted to choose as var-                                                      nologies work for animals, keeping an
ied a soundtrack as possible. The re-                                                   open mind and leaving the human per-
searchers chose to play four different                                                  ception at the door.
soundtracks, avoiding sounds of ani-                                                      In addition to influencing what
mals that prey on sakis, or sudden and               “Sounds are really im-             sounds they want to listen to, the
loud noises.                                      portant to many animals               white-faced sakis were able to influ-
  The Animal-Computer Interaction                  in their communication               ence the final form of the device. The
research team at Aalto University’s                    with each other. The             researchers initially tested two proto-
Department of Computer Science                       rainforest is full of dif-         types and built the final sound device
designed and built a tunnel-shaped                  ferent sounds and little            from the option that the monkeys used
sound device of wood and plastic for              monkeys are supposed to               significantly more.
small monkeys, which was placed in                 be sensitive to different              The tunnel-like box with a plywood
their own residential area in the Am-                                sounds”            floor and a transparent acrylic roof
azon House of Korkeasaari Zoo. The                                                      was the sakis’ favourite. Both mate-
monkeys were able to turn the device                                                    rials were already familiar to white-
on themselves and therefore decide to                                                   faced sakis, and thanks to the shape
listen to sounds or remain in silence.                                                  and materials of the box, the tunnel
  ‘We didn’t measure welfare fac-                                                       acoustics were good without having to
tors, but from a welfare perspective,                                                   completely close the space. The shape
it was essential to give animals de-       animals in their communication with          and material were suitable for their
cision-making power and indepen-           each other. The rainforest is full of dif-   habitat and to support the species-spe-
dence. These issues have been linked       ferent sounds and little monkeys are         cific behaviour of the animals.
to well-being in other studies. Instead    supposed to be sensitive to different          Dr. Pynnönen-Oudman from Kork-
of just playing music and other sounds     sounds.’                                     easaari Zoo says that sound stimuli
in their living environment and see-         The fact that animals are so inter-        have been used in zoos to some extent,
ing how it works, we gave them a sys-      ested in sounds is also reflected in the     but so far quite little has been tailored
tem that they could approach and use       results of the study. The sakis were al-     to particular species. ‘This could very
themselves,’ says Roosa Piitulainen,       lowed to choose how much either calm         well be the way of the future to stimu-
the first author of the research paper     music, fast-paced electronic music,          late the life of zoo animals.’
and doctoral candidate at Aalto Uni-       sounds of rain, silence, or traffic nois-
versity.                                   es they prefer to listen. The sakis pre-
  The researchers followed how the         ferred the sounds of traffic over all oth-
monkeys used the tunnel for several        er sounds.
months. They found that the sakis used       Ilyena Hirskyj-Douglas, postdoc-           By Anu Haapala

11
Research News

New epidemic modelling facilitates
assessment of corona strategies
Carried out as a joint project involving Finnish, Swedish and Norwegian researchers,
the model also takes into account network structures and human mobility.
Research, published: 13.11.2020

  The NordicMathCovid project aims           Traditional epidemic modelling does        skelä explains.
to model corona and future epidemics       not take into account the network              In addition to examining the spread
more extensively than has been previ-      structure, geographical location or hu-      of communicable diseases, the data
ously attempted. It also builds towards    man mobility. Modern network theory          and models may also be used to com-
long-term cooperation in mathemati-        provides computational methods for           pare diverse vaccination strategies.
cal modelling and extensive collection     modelling population contact struc-            ‘Mathematical modelling allows
of health data.                            tures, which is needed in order to as-       to explore and try to understand the
  ’One of the purposes of the project is   sess, for example, the contribution of       spread of the epidemic and also the
                                           school closures towards slowing down         question of who should be vaccinat-
                                           the epidemic.                                ed first,’ says Professor Tapio Ala-
                                             ‘We are studying large populations.        Nissilä.
                                           We do not assume that individuals              The research can also be used to ex-
                                           are associated to each other on an en-       amine the structure of the infectious
                                           tirely random basis; instead, we apply       disease situation.
                                           knowledge about how social networks            ‘Our research can tell us, for exam-
                                           are usually shaped: some people, such        ple, how working remotely affects the
                                           as superspreaders, have more con-            spread of the disease,’ Kivelä explains.
                                           tacts than others. In addition, social         The project is led by Professor Tom
                                           networks are clustered, which means          Britton from the University of Stock-
                                           that the connections are interlaced,’        holm and includes researchers from
         “Mathematical model-              explains Professor Mikko Kivelä.             Aalto University and the University of
           ling allows to explore            The large variations in contacts, mo-      Oslo as well as the countries’ national
          and try to understand            bility and social activity in different      health institutes: the Finnish Insti-
            the spread of the ep-          population groups have a significant         tute for Health and Welfare (THL),
             idemic and also the           impact on the spread of the epidemic         the Public Health Agency of Sweden
         question of who should            and the formation of immunity. In or-        and the Norwegian Institute of Public
             be vaccinated first”          der to understand these phenomena,           Health (NIPH). In addition to the sto-
                                           the project will develop new stochas-        chastics research group led by Lasse
                                           tic models.                                  Leskelä, the project also includes Mik-
                                                                                        ko Kivelä’s network science research
                                           Data from different sources                  group and Tapio Ala-Nissilä’s compu-
                                                                                        tational physics research group.
                                             The researchers are utilising an as          The budget for the two-year project
                                           diverse as possible range of realistic       comes in at just under EUR 1 million.
                                           and real-time medical, physical and          The project is funded by NordForsk.
                                           social data. At the general level, Statis-     The name of the project is ‘Data
                                           tics Finland is providing data related       streams and mathematical modelling
                                           to people’s mobility, with telecommu-        pipelines to support preparedness and
                                           nications operators providing more           decision making for COVID-19 and fu-
                                           detailed data. Vehicle data can be ob-       ture pandemics’. An objective for the
to compare different corona models         tained from road traffic. Local author-      future is to extend the cooperation in
and scenarios in different countries.      ities can provide structural data on         mathematical modelling to also in-
For example, we can apply Swedish          schools, which provides information          clude Denmark, Iceland and the Baltic
figures to conditions in Finland and       on which areas the pupils of different       countries.
Norway or see what would have hap-         schools are drawn from.
pened if Sweden had acted differently,’      ‘The data is always stored on the se-
says Professor Lasse Leskelä from Aal-     cure servers that belong to its owner or
to University.                             to the CSC IT Center for Science’, Le-       By Tiina Aulanko-Jokirinne

                                                                                                                             12
Research News

Towards trustworthy AI and an autonomous Europe
Professor Michela Milano is the Deputy President of
EurAI and one the keynote speakers at AI Day 2020
Research, published: 15.10.2020

  Europe needs to be autonomous in          start-ups in Europe after they become      straightforward, showing causal re-
terms of artificial intelligence (AI) and   successful, I believe Europe will have     lations – that outcome Y happens be-
create its own AI technology that re-       a very important and competitive ad-       cause of the factor X and these events
spects citizens’ privacy, says Michela      vantage with respect to other big play-    do not simply co-occur – is much more
Milano, Professor at the University of      ers.’                                      demanding.
Bologna and one of the leading AI re-        Taking privacy issues seriously is          ‘There are many, many aspects that
searchers in Europe.                        crucial. “For example in China, priva-     are considered important from the
  The European Commission wants             cy is not considered important at all      European point of view. Europe wants
European experts to build AI that peo-      and personal data are shared and used      to shape a strategy that differentiates
ple can trust, and according to EU’s        without any consideration. Europe          from other economies, like the US and
ethical guidelines, trustful AI is law-     should keep on taking these values and     China that have made huge invest-
ful, ethical, and robust. As the Depu-      aspects very carefully into account to     ments on AI. Europe is lagging behind
ty President of European Association        make something really different.”          a bit, but I think that the strategy that
for Artificial Intelligence (EurAI),         Building trustworthy AI is more com-      is going to build trustworthy AI in re-
Professor Milano has a central role in                                                 sponse to ethical principles is a good
this work and she supports the com-                                                    path.’
mission in shaping its AI strategies.                                                    Professor Milano has been an AI re-
She leads also the interdepartmental                                                   searcher for much longer than AI has
research institute for human-centred                                                   been the hot topic it is these days. She
artificial intelligence, Alma AI, in Bo-            “Europe wants to shape             remembers the time when people com-
logna, and in November, she will speak              a strategy that differen-          monly thought that AI methods were
about the European AI strategies at AI               tiates from other econ-           useless and researchers even avoided
Day 2020.                                             omies, like the US and           using the term to avoid scaring funders
  Europe needs to be able to compete                   China that have made            away. ‘But now of course everyone un-
against large economies, such as the               huge investments on AI”             derstands that it’s useful and can bring
US and China, in terms of AI. Accord-                                                  really important results and impacts
ing to Milano, its advantages include                                                  in all aspects of our life.’
the strong university system, the long                                                   Milano researches decision-support
history in conducting research of top                                                  systems and especially systems that
quality, and an industrial ecosystem                                                   support – rather than replace – hu-
that includes start-ups, big corpora-                                                  man experts. What Milano thinks is
tions, and everything in between.           plex than what it may sound. Milano        particularly fascinating in AI is that
  ‘We have all the components that are      points out that many AI systems “sim-      researchers can embed human knowl-
needed to create a significant strate-      ply work”, while we do not complete        edge in AI models. ‘You can really use
gy and to really create an autonomous       understand why they work. To create        these systems to put together knowl-
Europe. But there are problems, too:        trustworthy AI systems, researchers        edge from different experts, different
investments and the fact that start-        need to develop AI that is understand-     domains, and glue it all together with
ups can start here but as soon as they      able and explainable to humans.            data-driven models.’
become successful, they are bought            ‘We also need to have more collabora-      One aspect that fascinates her is the
by Google, Facebook, or another big         tion between AI systems and experts,       interdisciplinary nature of AI and, for
American player,’ Milano notes.             which is very difficult. That requires     example, ethical aspects that call for
  Another significant problem for Eu-       encapsulating the collaboration and        multidisciplinary approach. ‘When
rope is brain drain. ‘Talents are leaving   interaction with an expert. The system     you are in a driverless car, you need to
Europe because they can find better         needs to learn from humans how they        consider aspects that are not just al-
salaries and better conditions outside      solve problems, and that knowledge         gorithmic or technological. You really
of Europe. We really need to retain tal-    needs to be injected in the AI systems.’   have to understand that there are diffi-
ent. If we have a strategy with an eco-       When we are developing such sys-         cult decisions to make.’
system that is favourable for them, and     tems, we also face the issue of causal-      When e.g., lives are in question, mod-
for creating start-ups and keeping the      ity; while calculating correlations is     elling a system is particularly difficult

13
Research News

                                               Pekka Marttinen: It is very
                                               important to take good care of
                                               health and social services data
                                               The DataLit project develops understandable
                                               and reliable practices for using health and
                                               social services data
and ethical and moral principles should
come into place – and at the same time,        Research, published: 16.11.2020
there are many situations in which peo-
ple from different parts of the world do         Assistant Professor Pekka Marttinen is part of the new DataLit research con-
not follow any global moral guidelines.        sortium headed by Professor Petri Ylikoski of the University of Helsinki. The
While East Asians may think that it is         project aims to develop comprehensible and reliable practices for using Finnish
most important to protect the elderly,         data on health and social services.
Europeans put children’s safety first.           ‘My task is to develop machine learning methods and models for health and so-
  How to code these types of decisions         cial services data. With the help of these methods and models it is possible to
will be one of the key challenges in AI        examine societal questions related to health care’, Pekka Marttinen says.
research in the near future. On a posi-          The DataLit project brings together skilled people from many different fields.
tive note, a machine can be more ratio-        ‘In addition to the methods, it is important to examine what the models are used
nal than human decision makers can,            for and who use them, talk about them, and make decisions on how they are used.
as it can process information so quickly       As it is often said, the decisions must not be left to the engineers alone’, Martti-
that it can genuinely base its decisions       nen says.
on reasoning, while humans use their             The project analyses key ethical concepts – such as privacy – in a range of tech-
instinct.                                      nical, societal, and legal contexts, while examining how officials can use the data
  In the last few years, artificial intelli-   in a socially sustainable manner. DataLit also produces tools for the responsible
gence systems have developed at an ex-         and reliable use of register data, for example forecast models to support deci-
tremely fast pace. Professor Milano is         sion-making, and methods for anonymising data.
eager to see what types of results will be       ‘It is especially important to take good care of data. This means data security,
achieved in the next ten years; she hopes      consideration of ethical questions, the implementation of data analysis in a pro-
to witness a European AI field that is         tected environment – in general, the secure use of data. The use must be trans-
truly strong and competitive.                  parent and acceptable’, Marttinen says.
  Another thing she wishes to see is             The first phase of the project will take three years and its total budget is € 3.9
that researchers start using AI systems        million. In addition to the University of Helsinki and Aalto University, the Uni-
more to solve problems that help make          versity of Eastern Finland and several other cooperative partners are involved in
the Earth a better place for everyone;         the project: The Finnish Institute for Health and Welfare (THL), The Social In-
technology can help us reduce pollution        surance Institution (Kela), the Joint municipal authority for North Karelia so-
and emissions and hit the zero emission        cial and health services (Siun sote), the Cancer Society of Finland, the Ministry
and carbon neutrality targets.                 of Finance, Statistics Finland, the Digital and Population Data services Agen-
  ‘It is time for us to use technology for     cy, and the Helsinki Institute for Social Sciences and Humanities (HSSH). The
the good and help the environment and          project is implemented in close cooperation with the Finnish Center for Artifi-
improve our citizens’ quality of life.         cial Intelligence (FCAI).
Technological solutions really help us           ect they have tested the new solution with several collaborators. One of those
to go towards a better planet for us, our      collaborators is Elisa, a Finnish company offering telecommunications services,
children, and the next generations to          which announced a demo application developed during the collaboration.
come.’                                           One aim of the Aalto computer scientists is to try to find the customers who
  AI Day 2020 took place online on 26          will gain most benefit from the solution. ‘Our goal is to start a company that
November 2020.                                 brings the solution to the market.’ says Olavi Mertanen.
                                                 The CloudXR project in question is a TUTLI (From Research to Business)
                                               project funded by Business Finland and Aalto University that ended at the end
                                               of March 2020. The team has focused on exploring potential commercialization
                                               paths for XR applications’ remote rendering and developing the technology fur-
                                               ther.

By Anu Haapala                                 By Anu Haapala

                                                                                                                                14
Research News

AI predicts which drug combinations
kill cancer cells
A machine learning model can help us
treat cancer more effectively
Research, published: 1.12.2020

  When healthcare professionals treat        curately predicts how combinations         drug combination selectively inhibits
patients suffering from advanced can-        of different cancer drugs kill various     particular cancer cells when the effect
cers, they usually need to use a combi-      types of cancer cells. The new AI mod-     of the drug combination on that type of
nation of different therapies. In addi-      el was trained with a large set of data    cancer has not been previously tested.
tion to cancer surgery, the patients are     obtained from previous studies, which      ‘This will help cancer researchers to
often treated with radiation therapy,        had investigated the association be-       prioritize which drug combinations
medication, or both.                         tween drugs and cancer cells. ‘The         to choose from thousands of options
  Medication can be combined, with           model learned by the machine is ac-        for further research,’ says research-
different drugs acting on different          tually a polynomial function familiar      er Tero Aittokallio from the Insti-
cancer cells. Combinatorial drug ther-       from school mathematics, but a very        tute for Molecular Medicine Finland
apies often improve the effective-           complex one,’ says Professor Juho          (FIMM) at the University of Helsinki.
ness of the treatment and can reduce         Rousu from Aalto University.                 The same machine learning ap-
the harmful side-effects if the dosage         The research results were published      proach could be used for non-cancer-
of individual drugs can be reduced.          in the prestigious journal Nature          ous diseases. In this case, the model
However, experimental screening of           Communications, demonstrating that         would have to be re-taught with data
drug combinations is very slow and           the model found associations between       related to that disease. For example,
expensive, and therefore, often fails        drugs and cancer cells that were not       the model could be used to study how
to discover the full benefits of combi-      observed previously. ‘The model gives      different combinations of antibiot-
nation therapy. With the help of a new       very accurate results. For example,        ics affect bacterial infections or how
machine learning method, one could           the values of the so-called correlation    effectively different combinations of
identify best combinations to selec-         coefficient were more than 0.9 in our      drugs kill cells that have been infected
tively kill cancer cells with specific ge-   experiments, which points to excel-        by the SARS-Cov-2 coronavirus.
netic or functional makeup.                  lent reliability,’ says Professor Rousu.
  Researchers at Aalto University,           In experimental measurements, a cor-
University of Helsinki and the Uni-          relation coefficient of 0.8-0.9 is con-
versity of Turku in Finland developed        sidered reliable.                          By Anu Haapala,
a machine learning model that ac-              The model accurately predicts how a      Illustration Matti Ahlgren

15
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