Update on COVID-19 Pandemic in China and its Impact on Pharmaceutical Market - IQVIA Management Consulting March 20, 2020 - IQVIA.com

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Update on COVID-19 Pandemic in China and its Impact on Pharmaceutical Market - IQVIA Management Consulting March 20, 2020 - IQVIA.com
Update on COVID-19 Pandemic in China
and its Impact on Pharmaceutical
Market

IQVIA Management Consulting
March 20, 2020

                                       0
Update on COVID-19 Pandemic in China and its Impact on Pharmaceutical Market - IQVIA Management Consulting March 20, 2020 - IQVIA.com
In China, the battle ground for COVID-19 pandemic is shifted to screening
  and isolating imported cases from overseas
     Trend of new COVID-19 cases in China                                                 Number of new cases from overseas reached its peak,
                                                                                              while new domestic case approaching zero
             # of daily new cases in China                                                 140                       # of new cases from overseas
                                                                                           120                       # of new domestic cases
15,000                                                                                     100
14,000                                                                                      80
                                                                                            60
 5,000                                                                                      40
 4,000                                                                                      20
 3,000                                                                                       0
 2,000                                                                                          1-Mar            8-Mar            15-Mar            22-Mar

 1,000
       0
       19-Jan                  26-Jan                  2-Feb   9-Feb          16-Feb   23-Feb           1-Mar             8-Mar        15-Mar             22-Mar

                          Jan 23rd                                     Feb 12th                                                                Mar 17th
                                                                                                                Mar 6th
                  Lockdown of Wuhan                             New cases (13,332)                                                         New domestic cases
                                                                                                        New domestic cases
In the last 24 hours, the whole China, including Hubei has zero new domestic
cases, but 34 imported cases
         Hubei province (Wuhan being the state capital) has been
            under lockdown for 57 days since Jan 23rd, 2020
                                                                             Hubei province, excluding Wuhan, is
   As of Mar 19th, 2020                                                                being unlocked

                                                                            • 3,675 medical professionals from 41
                                                                             nationally recruited medical teams has left
                                                                             Wuhan

                                                                            • 46 COVID-19 designated hospitals in
                                                                             Wuhan planned to resume regular
                                                                             services in April

Number of existing patients                                                 • Wuhan aside, Hubei is gradually removing
        0
                                                                              traffic blockade
        1-9
        10-99                                                               • 49.3% manufacturers, mostly large
        100-499                                                              SOEs has reopened, with the rest reopen
        500-999
                                                                             after March 20
        1000-9999           China                         Hubei     Wuhan
          Existing
          Patients             7456                          6992    6744

Source: National Health Commission; IQVIA analysis; Public News                                                            2
Life outside Hubei is expected to return to normal in April, while recovery in
Hubei is expected in June

                                        • >90% manufacturing reopened outside Hubei, 49.3% in Hubei
                                        •     Pharmaceutical, chemical and electronics industries have recovered to   ~70% of original capacity
Manufacturing                           •     Government has taken actions to stimulate the economy, including low interest loan, tax subsidy and deferral

                                        •     Service sector has recovered to 67% of level seen in 2019 Q4 nationwide, ~30% in Wuhan

                                        • 90% of supermarkets, retail stores, restaurants and hotels have re-opened nationwide
   Commerce

                                        •     Nearly 100% of cross-state highways reopened and 80% local traffic resumed nationwide
                                        •     Other than Wuhan, Hubei unblocked all communities on Mar18th
Transportation

                                        • Schools are already open in 3 provinces (Qinghai, Guizhou, Xinjiang)
                                        •     All schools outside Hubei will gradually open throughout April
    Education                           •     Hubei schools are expected to reopen in June

Source: National Health Commission IQVIA analysis; Public News                                                                                               3
Hospitals/Sites increasingly re-opened from Feb, and 100% of the sites
outside Hubei will resume patient access by the end of May
       Outside Hubei, access to patients will return                                                                                In Hubei, access to patients started to recover in
               to normal by the end of May                                                                                               March and will recover to 70% in June
            % of hospitals                                                                                                                 % of hospitals
            back to BAU                                                                          100%                                      back to BAU                                      70%
100%                                                                        90%                                                70%
                                                                                                                               60%
   80%                                                                                                                                                                               50%
                                                                                                                               50%
                                                      60%
   60%                                                                                                                         40%
                                                                                                                                                                               30%
   40%                                                                                                                         30%
                                30%
                                                                                                                               20%
   20%                                                                                                                                                                10%
                10%                                                                                                            10%
                                                                                                                                            0                0
        0                                                                                                                            0
            Feb                Early                  End                    Apr                  May                                    Feb             Early         End     Apr   May    Jun
                                Mar                  of Mar                                                                                               Mar         of Mar

  •      By end of May, ~100% of the hospitals (outside Hubei)                                                                  •     By June, ~70% of hospitals in Hubei (excluding Wuhan), will
         will resume services with patient access                                                                                     resume services with patient access. Recovery in Wuhan may
                                                                                                                                      need additional 1-2 months

Note: Hospitals/Sites in Wuhan (90% of those in Hubei province), recovery progress is generally one month later compared to the rest of hospitals in Hubei province
Source: IQVIA analysis                                                                                                                                                                              4
Pharma market is affected in Q1 and Q2, but will gradually recover in Q3
                                                                                                 COVID-19 Impact in 2020
    China Pharmaceutical Market Prognosis, Bn RMB
             (Sales value, by quarter, 2020)                                1                    Regions: Hubei vs. Non-Hubei
                                                                            Hubei is seriously impacted by COVID-19 and it may take more time to
                         Forecast Adjusted / Forecast Baseline              recover
                                                                            • The outbreak ends in April and June outside and inside Hubei, respectively
                         Sales by Q, Forecast Baseline
                          Sales by Q, Forecast Adjusted                     • Hospitals repurposed for COVID-19 will resume normal function. The process
                                                                              takes longer time for Hubei than rest of China
     100%                                                  98%     99%
                                                                            2                      Channel: Hospital vs. Retail
                                        96%
                                                                            Hospitals, especially large hospitals have greater impact due to COVID-19,
       95%                                                                  while retail channel has limited impact
                      93%                                                   •    Nationwide quarantine reduces hospital visits
                                                                            •    More drug purchase and dispense shifted to retail pharmacy, including
                                                                                 online pharmacy
       90%                                              273 270             •    Reimbursement for online drug purchase likely to be piloted in Wuhan and
                   255                262 250                     258 255
                          237                                                    Shanghai
                                                                            3                       Therapeutic areas: by ATC
       85%                                                                  The impact varies by therapeutic areas
                                                                            •    Drugs for anti-viral, respiratory, and life-threatening diseases are least
                                                                                 impacted
                                                                            •    Drugs for chronic diseases and general surgery are moderately impacted
       80%                                                                  •    Drugs for adjuvant therapy and supportive care are most impacted
                   2020 Q1            2020 Q2           2020 Q3   2020 Q4

 Note: All projections are based on the constant inflation rate                                                                                               5
 Source: IQVIA analysis
Based on our best understanding, we project that growth rate will drop to -
2% and 0% in Q1 and Q2, respectively, then recover to 5-7% in Q3 and Q4
                                               China Pharmaceutical Market YoY Growth Trend (Sales value, 2016Q1-2020Q4)

                                                      2016                               2017                            2018                           2019                          2020

                               15                                                                                                                   13%
                                         11%                         11%
   YOY Growth %

                                                                                                                                                             10%
                                                                                                                                             9%                                                   9%
                     10%                          8%                                                                                                                8%                   6%
                                                           6%                                 6%                                      6%
                                                                                      5%                      5%                                                                   5%
                                5                                             3%                                                                                           5%
                                                                                                                              2%                                                                  7%
                                                                                                                      1%                                                                    5%
                                                                                                                                                                                   0%
                                                  YOY, Forecast adjusted by COVID-19                 -1%
                          0%                                                                                                                                               -2%
                                                  YOY, Forecast baseline

                               -5
                                          Q1      Q2       Q3        Q4       Q1      Q2      Q3      Q4      Q1      Q2      Q3      Q4     Q1      Q2      Q3     Q4     Q1      Q2       Q3    Q4

                                                 2016                                 2017                             2018                           2019                           2020

                                                                          ✓ Comprehensive reform on        ✓ Continue to implement a                                      ✓ Local lockdown and stay-
                                    ✓ Ensure drug quality and                                                                              ✓ VBP in 4+7 cities has been
                  Key Impact

                                                                            public hospitals, including      strict drug control policy.                                    home quarantine
                                      effectiveness.                                                                                         execution in March 2019.
                                                                            medical expenses control,      ✓ Implementation of Generic                                    ✓ Stringent cost
                                    ✓ Tendering & central                                                                                  ✓ Announced piloting DRGs
                                                                            the percentage                   Quality Consistency                                            containment of medical
                                      purchase, and reform pilot                                                                             payment system in 30
                                                                            of drug expenditure control      Evaluation.                                                    insurance
                                      of reimbursement price.                                                                                cities.
                                                                          ✓ Separation between             ✓ 17 oncology products were
                                      Integration of distributors.                                                                         ✓ 2019 NRDL update.            ✓ Decrease in out-of-
                                                                            medical and pharmaceutical       included in NRDL list .
                                    ✓ Clinical medicine use                                                                                ✓ Announced the result of        pocket expenditure
                                                                            services.                      ✓ Announced the result of
                                      standardization and drug                                                                               volume-based procurement
                                                                          ✓ Promotion of hierarchical        volume-based procurement                                     ✓ Disruption in commercial
                                      fee control                                                                                            in alliance regions.
                                                                            medical system.                  in 4+7 cities .                                                activities

 Note: All projections are based on the constant inflation rate                                                                                                                                        6
 Source: IQVIA analysis
We anticipate market rebound will continue throughout 2021 and recover
growth momentum by 2022
                                                             China Pharmaceutical Market Prognosis, 2018-2023
                      Forecast baseline
                      Forecast adjusted by COVID-19                                                                                             1,226
                                                                                                                           1,166
                                                                                                      1,108
                                                                                 1,048
                  Bn RMB                                            988                                                                         1,180
                                                                                                                           1,118
               (Sales Value)                    916                                                   1,059
                                                                                    1,012
                                               2018                 2019          2020                2021                 2022                  2023
                                                                    7.9%

                    Growth Rate                                                     6.1%              5.7%                 5.6%                  5.6%
                                               4.6%
                                                                                                                            5.2%
                                                                                  2.4%                                                           5.2%
                                                                                                      4.7%
                                               2018                 2019          2020                2021                 2022                  2023

                                       Short-term (2020-2021)                                                 Mid-term (2021-2022)
                      ✓ The outbreak of novel coronavirus affects the entire      ✓ Pharmaceutical market will regain the growth momentum and return to the
       Key Impact

                        pharmaceutical industry chain in 2020, including:           baseline growth rate from 2022, because
                           • Pipeline clinical research                                • Hospital service: impact from delayed and cancelled services will be fully
                           • Drug manufacturing and import                                minimized in 2021; more regular and strict control in the next flu seasons
                           • Drug distribution                                         • Tightened budget: limited healthcare funding on drugs with cost
                           • New product launch                                           containment; consumer confidence and willingness-to-pay will recover
                           • Sales and marketing activity                              • Delayed access timeline: negotiation and regular NRDL update will be
                           • Procurement and reimbursement                                delayed in 2020 and consequently impact on the local implementation
 Note: All projections are based on the constant inflation rate                                                                                                        7
 Source: IQVIA analysis
Thank You

            8
Appendix: Pharma market in Hubei took the biggest hit, hence takes longer
time to recover
                                  China Pharmaceutical Market Prognosis, by region, 2018-2023
                                                    (Sales value, Bn RMB)                                                                           Key Assumptions
                            Non-Hubei Forecast Baseline                                                  Hubei Forecast Baseline              •   Hubei is more influenced
                            Non-Hubei Forecast Adjusted                                                  Hubei Forecast Adjusted                  by COVID-19 than other
 1,500                                                                               60                                     52                    regions in China, the
                                                                    1,175                                     47     49
                                            1,061       1,117                                  42      44                                         forecast of pharmaceutical
                    947        1,004                                                 50 39                                     47
            877                                                                                                                                   market in Hubei and non-
 1,000                                                                               40                                 40
                                                        1,078       1,134                                        35                               Hubei would decease by
                                980         1,024                                    30                   32
                                                                                                                                                  28.3% vs. 2.4% compared to
  500                                                                                20                                                           original forecast
           Decrease by           -2.4%                                                   Decrease by -28.3%
                                                                                     10                                                       •   It would take longer for
     0                                                                                0                                                           Hubei market to recover
      2018         2019         2020        2021          2022      2023               2018   2019    2020   2021   2022   2023

                                                                                                                                              •   For non-Hubei provinces,
                                      China Pharmaceutical Market Prognosis, by region, 2020                                                      the outbreak would affect
                                                (Sales value, by quarter, Bn RMB)                                                                 2020 Q1 and Q2, while for
  Non-Hubei                                                                                                                                       Hubei province, the impact
                                                                                                                                                  would last for a whole year
                  Hubei              -3%                           -1%                  -1%                                                   “…Hubei pharma market would be
       -6%                                                                                                     Non-Hubei, Forecast Baseline
                                                                                                                                              very difficult this year due to traffic
                  -45%            251 243        -36%             262 261   -20%      247 245   -13%           Non-Hubei, Forecast Adjusted   control, infection risks, etc. and
    244 231
                                                                                                               Hubei, Forecast Baseline       major work of most institutes is
                                                                                                                                              epidemic control…”
                  11    6                      11     7                     12   9              11   9         Hubei, Forecast Adjusted        —Director of Class 3 hospital in SH
          2020 Q1                       2020 Q2                      2020 Q3              2020 Q4

 Note: All projections are based on the constant inflation rate                                                                                                                         9
 Source: IQVIA analysis
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