ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation

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ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
ARE
VACCINES
SAFE?
V3.0 July 2021
Latest version always available at stephenhawkingfoundation.org/vaccines
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
If you were offered a
COVID vaccine today,
would you take it?
Hands right up for YES

Hands down for NO

Hands in the middle for
‘I’M NOT SURE’
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
How worried are you
about the COVID
vaccine?

Why?
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
Here are some
common concerns
   I’m worried it was rushed

   I’ve heard scary stories about vaccines and
    I don’t know what to believe

   I don’t know what’s in it

   I’m worried about side effects

   I’m worried about the long term effects –
    will it make us ill in the future?
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
Some people think there’s no need
                                                                            It’s a
                                                                         disease for
                          It’s no                                        old people
                        worse than                  The vaccine
    I’m not                  flu
 likely to get                                     won’t stop me
    COVID                                          passing it on
                                                      anyway

                             I’ve had it so                                   The vaccine
                              I’m already                                     won’t work
                                immune                     Hardly             against new
       I’m young and                                     anyone has             strains
       healthy and so                                       died
       won’t get sick

                                              Let’s find out if any of this is true….
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
WHAT ARE
VACCINES
AND HOW DO
THEY WORK?
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
Some vaccines work like this…
                             Scientists kill the virus
                             or bacteria and break
                             it apart into harmless
                                     pieces
        HARMFUL
        VIRUS OR
        BACTERIA

                                                         They use harmless
          The vaccine teaches                             parts of the virus
          your body what the                                or bacteria to
        virus or bacteria looks                          create an injection
        like so that your body
          recognises the real
           virus in the future
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
Others work like this …
                                     Scientists weaken
                                        it to make it
                                      harmless before
                                          injecting
             HARMFUL
             VIRUS OR
             BACTERIA

      The main ingredient of a
     vaccine is a tiny weakened
     part of the virus or bacteria
     (antigen) so your immune
     system learns to recognise
      the real one quicker and
         better in the future
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
Or like this …
                              Scientists extract
                                RNA or DNA
                                instructions
             HARMFUL
             VIRUS OR
             BACTERIA

         DNA or RNA
    instructions which tell
      your cells to make
      parts of the virus or
         bacteria so it
      recognises the real
       one in the future.
ARE VACCINES SAFE? V3.0 July 2021 Latest version always available at stephenhawkingfoundation.org/vaccines - The Stephen Hawking Foundation
WHY ARE
VACCINES
USEFUL?
Tetanus

Why are vaccines                                    This is a child
                                                    suffering from the
                                                    painful muscle
useful?                                             contractions of
                                                    tetanus.

   Vaccines mean that diseases which used to
    kill us have largely disappeared.
                                                    Smallpox
   Smallpox, polio and tetanus that used to kill   An example of a
    or disable millions of people are either gone   disease
                                                    eradicated by
    or seen very rarely.9                           vaccination.11

   If people stop having vaccines, it allows
    infectious diseases to spread quickly again.

                                                    Polio
                                                    The last case of
What would our lives be like if we all stopped      polio in the UK
having vaccines?                                    was in the mid
                                                    1980s! 12
WHEN WILL I
GET THE
VACCINE?
What about me?

   The first priority was to protect people at high risk – this
    means older people and people with underlying health
    conditions. Older people are more likely to suffer serious
    illness and death from Covid than under 25s, also people
    with conditions such as diabetes or obesity.

   This means most vaccine programmes started with the
    oldest people and worked towards the younger ones.

   Some countries decided to vaccinate key workers such as
    teachers and health care workers early on.

   Israel also decided to vaccinate 16-18 year olds as they are
    the most likely to spread disease. This also allowed them to
    take their exams.
When will I get
a vaccine?

   Vaccine trials need volunteers to go through
    the three-stage process. Until recently, all
    trials for covid vaccines used adult volunteers
    due to the urgency of the pandemic and
    ethical concerns about trialling medicines on
    children and adolescents.

   Trials have now started on children and
    adolescents for Covid vaccines. A Covid
    vaccine for children should be ready by the
    autumn.
What happens when I
get vaccinated?
Doctors want to convince your body that it’s been infected,
so that it knows what the real virus looks like.

You might experience: 1

   The area where the needle went in looking red, swollen
    and a bit sore for 2 to 3 days.

   Feeling a bit unwell or developing a high temperature for
    1 or 2 days.

This is normal and is part of a healthy immune response to
the vaccine. It helps your body remember.

Similar to when you try any new food or take a new
medication, an allergic reaction can happen. But for
vaccines this is extremely rare.
ARE
VACCINES
SAFE?
What is the
evidence?
   Overwhelming medical evidence shows that
    serious negative side effects are extremely
    rare.2

   Improved safety means that researchers are
    often searching for vanishingly small risks.3

   Vaccines must undergo stringent safety tests
    before distribution. There is also constant
    monitoring and investigation of significant
    reported side effects. 3

   Nothing in medicine is 100 percent safe. But
    the benefits of taking the vaccine to prevent
    a potentially deadly and debilitating disease
    far outweigh the risks. 4
DO VACCINES
CAUSE
AUTISM?
There is no link between
vaccines and autism
 In the 1990s, a doctor reported a study on 12 children which he claimed
  showed that vaccines caused autism.

 Autism is a form of neurodiversity; this means it is a genetically-
  determined difference in the brain which results in different ways of moving,
  speaking, seeing the world, and socialising.

 Studies worldwide on hundreds of thousands of children have shown that
  vaccines do not cause autism.

 The claims caused mass panic about vaccinations and have resulted in many
  children missing out on vaccines which could have protected them from
  serious illnesses and in some cases, life long impacts of disease.

 But no link has ever been found between vaccines and autism.

What do you think about ‘evidence’ produced from 12 children compared
to evidence from hundreds of thousands of children worldwide?
WHY DO WE
NEED A
COVID
VACCINE?
We need a COVID
vaccine because:
   Nearly five million people have died from COVID

   Society, including education, employment, sport and
    medical care, has shut down during the COVID pandemic –
    a vaccine may be the best way we have to open the world
    up again.

   Long COVID – 1 in 10 people aged between 18-49 who get
    COVID go on to suffer long COVID which can be very severe
    and cause life-long health problems such as headaches,
    brain fog or even damage to your internal organs.

   Worryingly, new data shows that long COVID is affecting
    both children and adolescents.

Would you get a COVID vaccine to protect your family
and friends?
WHAT DOES
THE COVID
VACCINE DO?
What does the COVID
vaccine do?
   The COVID vaccine gives you up to 95% protection against
    getting COVID, being hospitalized, and getting the severe
    version of the disease.

   The vaccines significantly reduce transmission. Many
    people have ‘asymptomatic’ COVID which means they have
    it without even knowing. But they can pass it on to
    members of their family such as grandparents.

   Even if you’ve had COVID, scientists still think you should
    have the vaccine as this will boost your ability to fight the
    virus if you come into contact with it again.

How much has the vaccine already reduced transmission
in the UK?
What does the COVID
vaccine do?
   Better protection if you’ve had the vaccine against a wider
    number of variants.

   It will help to create community (or “herd”) immunity – so
    that virus levels drop enough for us to get back to our lives.

   Some people can’t take the vaccine for medical reasons –
    they need to be protected by everyone else having it.

   If people don’t take the vaccine, the virus will carry on
    infecting people and the longer it does, the harder it will be
    to stop because it will mutate.

Should we act as a community for the good of all?
IS THE COVID
VACCINE
SAFE?
How was the vaccine
developed so fast?

    Lots of money!   Lots of resources   International
                                         effort

    Scientists       Very few            Stages carried
    working around   “wasted” days       out in parallel
    the clock

    Nothing          All safety          Approved by
    missed           checks in place     independent
                                         regulatory body
How are vaccines
monitored?
   Health agencies continue to monitor
    vaccines after they have been approved and
    are being used.

   Millions of people have been given a COVID
    vaccine and reports of (more than mild) side
    effects, such as allergic reactions or blood
    clots, have been rare. 14

How many millions of people have had the
COVID vaccine so far?
What the vaccine doesn’t do

                        It doesn’t
                       change your          It doesn’t
   It doesn’t give         DNA             contain any
     you COVID                              animal or
                                         human material

                     It doesn’t change
                      your personality
                          or sexual
        It doesn’t       orientation
         contain                          It doesn’t
        microchips                       affect your
                                           fertility
Are you scared about
side effects of the
COVID vaccine?
   Serious side effects linked to any of the
    COVID vaccines are rare.

   These side effects have only come to light
    when millions of people were vaccinated.

   Many every day activities carry a greater risk
    to your health than taking a COVID vaccine.

You are much more likely to become seriously
ill from COVID than from the vaccine
What we know –
and what we don’t
   An unusual blood clot is now known to be extremely rarely
    associated with a certain type of COVID vaccine which
    includes the Astra Zeneca vaccine, the Johnson&Johnson
    vaccine and the Russian Sputnik V vaccine. These are called
    the adenovirus vector vaccines.

   The RNA vaccines – Pfizer and Moderna – are rarely
    associated with another type of blood clot. This is being
    investigated in the USA.

   The AZ-associated blood clot is thought to be caused by an
    unusual antibody which makes blood clots form in rare
    places in the body.

   This is an immune response which happens 7-21 days after
    vaccination. It is not yet known why this happens or to
    whom although scientists are working on different theories
    and preventions.
How big is the risk?
                                       Risk of blood clot
   This is an extremely rare          3.0
                                      15.0
    side effect. Covid is still far   10.0
                                       2.5
    more dangerous.
                                      2.0
   You are far more likely to         1.5
    suffer a blood clot from
                                       1.0
    Covid than from the
    vaccine.                          0.5

                                      0.0
                                               AZ vaccine Birth control                     Smoking Severe COVID
                                          (for younger women) in women
                                         ~1 in 200,000/250,000 ~1 in 1,000                ~1 in 500/1,000         ~1 in 6/7
                                            (0.0004-0.0005%)      (0.1%)                     (0.1-0.2%)            (15%)
    Covid vaccines are still
    safe and effective.                      These figures will vary around this estimate according to factors such as age,
                                             gender, wealth, ethnicity, access to health care, education, etc.
WHAT
HAPPENS IF
YOU GET
COVID?
What does
COVID do to you?
   COVID-19 can give you a life-threatening
    pneumonia
   It’s worse than flu (and flu can kill up to
    30,000 in a bad flu year)
   It’s not just old people, or ill people
   If you get sick, you may need a hospital bed
    and oxygen, but others may need them too.
    If the NHS gets overwhelmed, there may not
    be enough to go round
   Long COVID could leave you with life long
    health problems
   New data shows long covid can affect
    children and adolescents

COVID causes death
HOW DO I
KNOW WHO
TO TRUST?
Where do you get your news?
We get information or news from many places TV, TikTok,
Instagram, Twitter, The Government, school, our friends and
families, news alerts, rumours.

   News and how it is reported is out of our control, so we
    need to decide for ourselves what to believe.

   If you just have one source of information, you might not be
    hearing the whole story.

   Fact-checking and myth-busting are two ways society
    checks whether news is real.

   You can do it yourself with simple research; listen to
    different news sources, analyse the results and form your
    own opinion.

Do you 'think before you forward’?
You can stop fake news spreading by not passing it on.
What is a conspiracy theory?
   It is an alternative explanation for an event or a
    situation that relies on sinister actors and
    motivations rather than hard evidence.

   Often, conspiracy theories are associated with new
    technologies or scientific achievement.

   Psychologists believe that the availability of the
    internet and social media is one reason why
    conspiracy theories to become more common, as
    we can now easily access a large amount of
    unverified information.

Have you heard any conspiracy theories?
Is the Earth really flat?
   A group called the Flat Earthers has tried to
    persuade us that the Earth is flat. This goes
    against all the evidence including the images
    from space!

   Psychology studies show that people who
    believe in conspiracy theories tend to be more
    anxious, paranoid, or suspicious compared to
    people who don’t believe in conspiracy
    theories.

   People believe more strongly in conspiracy
    theories at times of social and political unrest –
    such as during a pandemic!

How can you tell fact from fiction?
Does the vaccine go against my
religious beliefs or my diet?
   The Pfizer BioNtech vaccine contains no animal products.
    Previous vaccines, including the Pfizer BioNtech vaccine have
    been declared halal by Islamic scholars worldwide.

   The British Islamic Medical Association has recommended the
    Astra Zeneca vaccine for members of the Muslim community.
    There are no animal products in the AZ vaccine.

   The Hindu Council of the UK made this statement in January
    2021: “We urge all members to dispel rumours that vaccination
    does contain any animal fat. We have been categorically
    assured by scientist as well as the government ministers that
    both vaccines do not contain animal products.”

   Ethical vegans are advised that while the vaccines were tested
    on animals, they contain no animal products and they should
    still get the vaccine for their own protection and that of others.
Weighing up the odds
                                                  Much less likely
                                                    to get sick
                A bit of
                                                   or get long
           inconvenience, a
                                                      COVID
             day of feeling
                 tired

                                                                 Protect those
 Tiny risk of side                                               around you –
     effects                                                       especially
                                                                vulnerable and
                                                                 older people

                              Play your part in
                              helping to beat
                              the pandemic…
HOW
INFORMED
DO YOU FEEL?
Now, would you take
the COVID vaccine?

Hands right up for YES

Hands down for NO

Hands in the middle for
‘I’M NOT SURE’
What were all those little numbers?

        1                                   9

                                                                    7
                  2
                                       11

            5                                            14

We use references to cite our sources of information so that other people can go
and check them.
References
1.   Why vaccination is safe and important. NHS Website. (2020).               8.    Hviid, A., Hansen, J., Frisch, M. and Melbye, M. (2019). Measles,
     [Accessed 29/12/2020 at:                                                        Mumps, Rubella Vaccination and Autism: A Nationwide Cohort
     https://www.nhs.uk/conditions/vaccinations/why-vaccination-is-                  Study. Annals of Internal Medicine, American College of
     safe-and-important/]                                                            Physicians. [Accessed 29/12/2020 at:
                                                                                     https://www.acpjournals.org/doi/10.7326/M18-2101]
2.   Maron, D. (2015). Fact or Fiction?: Vaccines are Dangerous.
     Scientific American. [Accessed 29/12/2020 at:                             9.    Why vaccination is safe and important. NHS Website. (2020).
     https://www.scientificamerican.com/article/fact-or-fiction-                     [Accessed 29/12/2020 at:
     vaccines-are-dangerous/ ]                                                       https://www.nhs.uk/conditions/vaccinations/why-vaccination-is-
                                                                                     safe-and-important/]
3.   Kwok, R. (2011). Vaccines: The real issues in vaccine safety. Nature,
     473, pp 436-438. [Accessed 29/12/2020 at:                                 10. Daley, M. and Glanz, J. (2011) Straight Talk about Vaccination.
     https://www.nature.com/news/2011/110525/full/473436a.html]                    Scientific American. [Accessed 29/12/2020 at:
                                                                                   https://www.scientificamerican.com/article/straight-talk-about-
4.   Godlee, F. (2011). The fraud behind the MMR scare. The BMJ,
                                                                                   vaccination/]
     342:d22. [Accessed 29/12/2020 at:
     https://www.bmj.com/content/342/bmj.d22]                                  11.   Parrino, J. and Graham, B. (2006). Smallpox vaccines: Past, present
                                                                                     and future. Basic and Clinical Immunology, The Journal of Clinical
5.   Carr, J., Clements, C., Martin, R. and Ritchie, P. (2000). Behavioural
                                                                                     Immunology, 118(6), pp1320-1326. [Accessed 29/12/2020 at:
     factors in immunisation. World Health Organisation. [Accessed
                                                                                     https://www.jacionline.org/article/S0091-6749(06)02013-6/fulltext]
     29/12/2020 at:
     https://www.who.int/mental_health/media/en/28.pdf?ua=1]                   12. Polio. NHS Website. (2020). [Accessed 29/12/2020 at:
                                                                                   https://www.nhs.uk/conditions/polio/]
6.   ‘No link between MMR and autism,’ major study finds. NHS
     Website. (2020). [Accessed 29/12/2020 at:                                 13. Kostoff, R., Briggs, M., Porter, A., Spandidos, D. and Tsatsakis, A.
     https://www.nhs.uk/news/medication/no-link-between-mmr-and-                   (2020). COVID-19 safety. Int J Mol Med, 46(5), pp1599-1602.
     autism-major-study-finds/]                                                    [Accessed 29/12/2020 at:
                                                                                   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521561/]
7.   Plotkin, S. Gerber, J. Offit, P. (2009). Vaccines and Autism: A Tale pf
     Shifting Hypotheses. Clinical Infectious Diseases, 48(4), pp456–461.      14. Coronavirus vaccine. NHS Website, (2020). [Accessed 29/12/2020
     [Accessed 29/12/2020 at: https://doi.org/10.1086/596476]                      at: https://www.nhs.uk/conditions/coronavirus-COVID-
                                                                                   19/coronavirus-vaccination/coronavirus-vaccine/]
Finally, the BIG question

What do YOU think?

We are constantly revising this presentation based on the latest scientific
information and feedback from students, teachers and scientists.

Let us have your feedback at
stephenhawkingfoundation.org/vaccinesfeedback

V2.0 23 April 2021
Latest version always available at stephenhawkingfoundation.org/vaccines
Produced by

                                  Researched and produced by Edmund Stubbs,
                                  Science Teacher, Morpeth School, London in
                                  collaboration with Dr Emily Grossman.

                                  Reviewed by Professor Daniel Pennington,
                                  Centre Lead for Immunobiology, Queen Mary
                                  University, London.

In collaboration with:

Presentation and materials designed by Glazier Design — www.GlazierDesign.com
Thank you
The Chair and Trustees of the Stephen Hawking Foundation are especially grateful to the teacher,
Edmund Stubbs, who provided the impetus for this project, and they would also like to thank all those
who helped contribute to the research and development of this presentation:

Heidi Larson, Founding Director of the Vaccine Confidence Project    June Kelly MBE, Abraham Moss Warriors
at the London School of Hygiene & Tropical Medicine                  Kimwei McCarthy, Head Mentor with AMSonline
Nura Aabe, Health Inclusivity Researcher, Autism Independence        Prof Daniel Pennington, Professor of Molecular Immunology, Queen
Dr Tina Chowdhury, Associate Professor in Regenerative Medicine,     Mary University London
Queen Mary University London                                         Dr Mala Mawkin, Host of Royal Society of Medicine's Digital Health
Michael Cockerham                                                    Podcast, innovation researcher, writer and award winning speaker
Phineas Cockerham, Photographer & son                                Heather MacRae, Founder of Venture Thinking
James Follows, Politics student, Nottingham University               Prof Daniel Pennington, Professor of Molecular Immunology, Queen
                                                                     Mary University London
Kristen De Graaf, Research Fellow for the Vaccine Confidence
Project™                                                             Simeon Quarrie Founder of Vivida, storyteller who specialises in
                                                                     immersive and virtual reality training
Dr Vincent Giampietro Neuroscientist Kings College London
                                                                     Ted Smith, Trustee, Ideas Foundation
Leon Gidigbi, Amos Bursary Trust Scholar and YE2030 Advocate
                                                                     Edmund Stubbs, Teacher, Morpeth School
Ben Glazier, Managing Director, Glazier Design
                                                                     Annie Taylor, Student Herts and Essex High School
Dr Emily Grossman, science communicator, writer and expert in
molecular biology and genetics                                       Ellie Taylor, Student Herts and Essex High School
Michael Healy, Chief Executive of Octagon Studio                     Claire Taylor. Pharmaceutical Director
Dr Sophie Hodgetts, Lecturer in Psychology, Sunderland University    Peter Thomas, National Association of Teaching of English
Gemma Hodgson, Qi Statistics                                         Robin Wight CBE, President of The Engine Group, co-founder of
                                                                     advertising agency WCRS and founder of the Ideas Foundation
Kulvinder Johal, Association of Science Education, Science Teacher
of the Year Award in 2012
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