Canada's Strategy for Patient-Oriented Research (SPOR) Overview and Update - Presentation for the Workshop on Patient-Oriented Research ...
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Canada’s Strategy for Patient-
Oriented Research (SPOR)
Overview and Update
Presentation for the Workshop on Patient-Oriented Research
University of Saskatchewan
November 13, 2014
Nancy Mason MacLellan
Manager, Major Initiatives, CIHR
CANADIAN STRENGTHS
Canada Excels In All Health Research Sectors
Clinical Medicine
More Impact
Biology Public Health and
Average Relative Citations (ARC)
Health Services
World Average
Biomedical Research Psychology and
Cognitive Sciences
Less Impact
Less Specialized World Average More Specialized
Specialization Index (SI) 2
Source: The State of Science and Technology in Canada, 2012
CANADIAN STRENGTHS
Strong Intl. Research Collaboration
3
Source: The State of Science and Technology in Canada 2012
CANADIAN CHALLENGES
4SPOR – A SOLUTION
The Strategy for Patient-Oriented Research - a coalition of
federal, provincial and territorial partners, including
patients, researchers, health practitioners,
provincial/territorial health authorities, policy makers,
academic health centres, charities, and the
pharmaceutical sector, working together to generate
and translate high quality, relevant research into practice.
Patient-oriented research aims to ensure that
the right patient receives the right intervention
at the right time
5PRINCIPLES
• Patients need to be involved in all aspects of the research to ensure
questions and results are relevant and integrated into practice
• Decision-makers and clinicians need to be involved throughout the
entire research process to ensure integration into policy and
practice
• Funding under SPOR is based on a 1:1 matching formula with non-
federal government partners to ensure relevance and applicability
• Effective patient-oriented research requires a multi-disciplinary
approach
• SPOR is focused on first-in-human (and beyond) research designed
to be transformative in nature and improve patient outcomes and/or
the effectiveness and efficiency of the health care system
• SPOR is outcome driven and incorporates performance
measurement and evaluation as integral components of the initiative
6CORE ELEMENTS
Support for People and Patient-Oriented
Research and Trials (SUPPORT) Units
SPOR Networks
Capacity development
Improving the clinical trials environment
Patient engagement
7SUPPORT UNITS
SPOR SUPPORT Units: provincial/territorial/regional centres providing support
and expertise to those engaged in patient-oriented research including a focus
on data access, methodological and research services, knowledge translation,
clinical trials and capacity development
STATUS UPDATE
• Alberta, Manitoba, Ontario, Quebec, Data Platforms &
Maritimes (PEI, NB, NS), and Services
Newfoundland & Labrador are at
varying stages of implementation
Consultation &
• British Columbia to submit in fall 2014 Methods Support
Research
& Development
and Saskatchewan to submit in winter Services
2015 Collective
• NWT received seed funding toward Priorities
the development of a business plan Health Systems,
Career
• Dialogue continues with Nunavut and Development in KT &
Yukon to develop an appropriate way Methods & HSR Implementation
for them to intersect with SPOR
• The SPOR SUPPORT Unit Council Real World Clinical
has been established to link Trials
representatives from across the
SUPPORT Units
8NETWORKS
National research collaborations of patients, health professionals,
decision makers, health researchers and other stakeholders to generate
evidence and innovations designed to improve patient health and health
care systems
9NETWORKS
Transformational Research in Adolescent Mental Health: is co-funded by the Graham
Boeckh Foundation (GBF). The Network will use TRAM funds, participant resources and
leveraged investments in ways most likely to improve the mental health outcomes of 11-25 year
olds over the next five years.
UPDATE: On June 13, 2014, CIHR and GBF formally announced the launch of
ACCESS Canada, the successful TRAM Network in Youth and Adolescent Mental
Health, led by Dr. Ashok Malla. Key members span six provinces and one territory.
Primary and Integrated Health Care Innovations: includes targeting individuals with complex
needs across their life course; showing capacity to evolve the network’s scope over time to
include age groups from children to older adults; and proposes multi-sector integration of
upstream prevention strategies and care delivery models.
UPDATE: Network is being implemented using a phased approach. The 11
member networks are currently working on their applications to become official
members of the pan-Canadian Network. Spans all provinces and one territory.
Networks in Chronic Disease: CIHR led a consultation to inform decisions of the National
Steering Committee regarding the next network opportunities to be launched; the
development of an opportunity for networks in chronic disease, through an open competition
process was recommended by the National Steering Committee.
UPDATE: A multi-phase funding opportunity for SPOR Networks in Chronic
Disease was launched in October 2014.
10DEVELOPING CAPACITY
To grow, support and sustain a collaborative, interdisciplinary and
innovative patient-oriented research environment capable of addressing
evolving health care questions, contributing to enhancing patients’
health care experience and improving health outcomes.
11CLINICAL TRIALS ENVIRONMENT
Through a partnership between CIHR, Canada’s Research-Based Pharmaceutical
Companies (Rx&D), and HealthCareCAN , the Canadian Clinical Trials
Coordinating Centre (CCTCC) was created to:
• Measure, monitor and market clinical trial performance improvements
• Leverage existing work on accreditation, harmonization and streamlining ethics
reviews and common contracts
• Develop a database of patient registries and consider national recruitment
strategies
• Attract international investment in clinical trials
STATUS UPDATE
• A 12-member National Advisory Committee has
been formed to provide advice to the Executive
Committee.
• The Canadian Clinical Trial Asset Map
(CCTAM) has been developed and will officially
be launched in early 2015
• A Model Clinical Trials Agreement has been
developed
• Work on an accreditation system for Canadian
Research Ethics Boards continues
• A Working Group on Patient Registries has
been formed 12PATIENT ENGAGEMENT
Occurs when patients meaningfully and actively collaborate in the governance, priority
setting, and conduct of research, as well as in summarizing, distributing, sharing, and
applying its resulting knowledge
STATUS UPDATE
In response to the SPOR Patient Engagement Framework published in June 2014, the
CIHR Citizen and Patient Engagement Implementation Strategy is introducing a number
of cross-cutting mechanisms across three core areas:
Governance and Capacity Building Tools and Resources
Decision-Making
Ensuring that citizen and patient Ensuring that resources are available Ensure tools and resources are
engagement is embedded in to facilitate the participation of citizens available to citizens and patients to
CIHR programs/processes and patients in CIHR help prepare them to effectively
programs/processes and POR contribute to/participate in CIHR
programs/processes and POR
Ex. Patient and Citizen Ex. Funding opportunities for the
Participant Pool; mechanism to research community and knowledge Ex. Orientation tool for boards and
capture patients and citizens in users to form active collaborations committees; development and roll-
the College of Reviewers; an whereby citizens and patients are out of a curriculum to prepare
incentives/compensation policy engaged early and often in POR; patients for engagement in
to compensate citizens and development of a Citizen and Patient research; development of a ‘jargon
patients participating in research Engagement Community of Practice buster’ to explain research termsKEY BENEFITS
• Improved health for Canadians by ensuring that the best research evidence
moves into practice, enhancing the health care experience for patients and
improving health outcomes for Canadians
• Economic benefits by optimizing spending on health care systems,
reinvesting resources where the evidence shows that these can have
greatest impact, and attracting private investments in evaluative research
• Driving innovation in patient-centred care in areas like e-health,
implementation science and clinical practice
• Linking provinces and territories by providing jurisdictions with
opportunities to learn from each other, translating best practices in patient-
centred care across Canada, and benefitting all Canadians
• Reversing the decline in private sector clinical research by creating an
environment that makes it easier to pursue clinical research in Canada
14DISCUSSION and QUESTIONS?
- Appendix - Networks in Chronic Disease
SPOR Networks in Chronic Disease Definition of Chronic Disease: non-communicable, long-term disease that is not passed from one person to another; it evolves over time, often progressing in severity. Although a non-communicable chronic disease may be prevented and can often be controlled, it is rarely cured. Focus of the Networks: Anchored on the challenges in Valley 1 research as it bridges to Valley 2. First-in-human and beyond research in chronic diseases that have resulted in areas of high disease burden. Networks are strongly encouraged to explore the opportunities for impact across multiple chronic diseases. No more than one network will be funded in any particular focus area. Successful networks are expected to include relevant international collaborations. 17
SPOR Networks in Chronic Disease
Phase Major Step Key Points Timeline
Important
Phase dates:
I Registration • Administrative only and will December 2014
be used to facilitate reviewer
recruitment
Letter of Intent • Reviewed by an international January –
panel of experts
March 2015
• Top 20 in the fundable range
will be provided with a $50K
development grant and will be
invited to a strengthening
workshop
Phase II Strengthening • Mandatory for all successful Spring 2015
LOIs
Workshop(s)
• Workshop to help strengthen
applications and encourage
dialogue between applicants
Phase III Full Application • Full applications submitted October 2015 –
and reviewed
January 2016
• Four distinct chronic disease
networks are funded
18SPOR Networks in Chronic Disease
Funds Available:
Each successful network will receive up to $12,500,000 over five
years from CIHR.
Up to 20 Development Grants will be funded through the Letter of
Intent stage.
• Each Development Grant will have a maximum value of
$50,000.
• Partner funds are NOT required at this stage.
Up to 4 Networks will be funded through the Full Application
stage.
• CIHR will provide up to $12.45M over five years per Network.
• Funds must be matched 1:1 with non-federal sources of
funding.
19SPOR Networks in Chronic Disease
Network Composition:
The network must demonstrate that it will be pan-Canadian in scope,
i.e., that it includes Principal Applicants (key members), from a
minimum of one province or territory in three of the following four
regions:
East – includes Newfoundland and Labrador, Nova
Scotia, Prince Edward Island and New Brunswick
Central – includes Quebec, Ontario and Manitoba
West – includes Saskatchewan, Alberta and British
Columbia
North – includes Nunavut, Northwest Territories and
Yukon
20SPOR Networks in Chronic Disease
Evaluation Criteria Categories for the LOI:
1. Vision, rationale, priorities and added-value
2. Potential for transformative impact
3. Patient-oriented research program
Quality of the proposed research program, including the evidence
that sex and gender considerations have and will be taken into
consideration.
4. Strength of the team
Appropriateness of the role described for the sex/gender champion.
5. Patient-oriented research training and mentoring strategy
6. Knowledge translation plan
7. Partnership plan
8. Governance
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