Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands

Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
Driving Life Sciences Business
In the UK Midlands Region
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
2                     Driving Life Sciences Business                                                                                         Driving Life Sciences Business                      3

                                                              Sir John Peace
    Contents                                                  Introduction

    Welcome to Midlands Engine for Growth                03   With an economy worth more
    Why Locate Here?                                     05   than £200 billion a year ...
    Strengths of the Midlands Engine                     07   the Midlands has become a real
    Core Life Sciences Business Resources                11   focus for UK Life Science research           Life Sciences has become a multi-billion dollar, global business. It tackles issues
    Regional Centres of Clinical Research Excellence 14       and business growth.                         which know no borders - health and disease, well-being and the ageing of
                                                                                                           populations – by fostering an environment of international co-operation.
    Trauma & Defence Medicine                                 Sir John Peace - Chairman, Midlands Engine
                                                                                                           With an economy worth more than £200 billion a year, the Midlands, with
     • Major Trauma Centres                              15                                                its excellent national and international transport connections, particularly in
                                                                                                           Birmingham and Nottingham, has become a real focus for UK Life Science
     • Orthopaedic Centres                               16
                                                                                                           research and business growth.
    Clinical Trials, Testing & Research                  20
                                                                                                           The Midlands is also driving the sector internationally, not least because our
    • Medical Supply Chain                               22                                                world-class universities, 7 of which have medical schools, promote strong
                                                                                                           collaboration between academia, industry and health.
    Trading Stories                                      24
                                                                                                           Due to a unique cluster of specialist provision, the Midlands is the UK’s centre
    The Future and in Progress                           27                                                for Trauma & Defence Medicine. The new Defence and National Rehabilitation
      • Life Sciences Space Opportunities                                                                  Centre is under construction at Stanford Hall in Nottinghamshire.

      • Science & Business Space Opportunities           29                                                The Midlands has stable yet diverse urban and rural population demographics
                                                                                                           and our Clinical Trial capability is extensive, with over 3,500 studies carried out
    Travel & Location                                    31                                                by regional health organisations in 2016.
    Support for Investors                                32                                                We have strong life science supply chains, including manufacturing companies
                                                                                                           and contract research organisations resulting in a diverse, adaptive and strong
                                                                                                           offer to inward investors.

                                                                                                           From Med-Tech to Bio, the Midlands offers a strong support network to
                                                                                                           businesses moving into the region. With specialist sector knowledge and
                                                                                                           local networks across the region, we offer support from the Academic Health
                                                                                                           Science Networks and Medilinks, through to our Growth Hubs.

                                                                                                           Our Centre for Healthcare Equipment and Technology Adoption at Nottingham
                                                                                                           University Hospital, was set-up as a direct response to the challenge from the
                                                                                                           NHS to adopt new devices and put new technologies into practice.

                                                                                                           The already strong economy of the Midlands will be further enhanced by the
                                                                                                           major investments the UK government is making, namely HS2 high speed rail,
                                                                                                           which will have a profoundly transformative effect on the region.

                                                                                                           As a Midlander I know what a great place the Midlands is to live and work in. As
                                                                                                           you read on, I hope you will realise this too.

                                                                                                           I hope you decide to join us.

                                                                                                           Sir John Peace
                                                                                                           Chairman, Midlands Engine
    Designed and produced by Medilink Midlands 2020 on
    behalf of Department of International Trade (DIT)
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
3                   Driving Life Sciences Business                                                                                  Driving Life Sciences Business                                                         4

                                                              Within top 3                                            14% of all UK Life Sciences employment is in
                                                                                                                      the Midlands (33,964 Jobs), identified as

                                                                                                                      within the top three by the Office of Life
                                                              for UK Life Sciences                                    Sciences (OLS).

    The Midlands Engine                                       The Midlands particularly excels in MedTech
                                                              specialist service and supply businesses, ranking          Ranked 2nd
    for Growth                                                first ahead of the South East and East of England,
                                                              with over 12,000 jobs and 14% of the national
    Located in the centre of the United                       employment total (12% in BioPharma and nearly               for specialist service and
                                                              20% in MedTech)
    Kingdom, the Midlands Engine is the                                                                                   supply companies
    heartbeat of the nation’s economy.
    The Midlands Engine is the place to do business, with a
    world- class research and innovation infrastructure                                                                The Midlands Engine has strength in core
                                                                                                                       MedTech industry, with 7% of employment
    including science and technology parks and business
    incubation facilities, alongside the delivery of          Second largest                                           (18,417 jobs) in Medical Technology, making the
                                                                                                                       Midlands the second largest UK employer in
    knowledge exchange programmes.
                                                                                                                       MedTech - This is further strengthened by the
    Home to the largest number of medical technology          UK employer in MedTech                                   Defence Medicine Rehabilitation Centre's
    service and supply companies in the country, with a                                                                location in the region.
    strong life sciences pedigree that stretches from
    Nottingham, with BioCity as its centrepiece, to
    Birmingham and the Institute for Translational
    Medicine. The region is also underpinned by a strong      In 2018/19, the Midlands Engine region
    private sector base containing globally significant       attracted 224 Foreign Direct Investment
    companies such as 3M, Abbott Healthcare, Orion
    Pharma., Parexel, Walgreens Boots Alliance, Reckitt
                                                              projects in total across the region, creating
                                                              over 6,000 new jobs and safeguarding a
    Benckiser, Catalent Pharma Solutions and Quotient         further 1,056. The region accounted for 16%
    Sciences, as well as key manufacturers Jaguar Land        of the UK’s overall exports in 2013, selling to
    Rover, Rolls Royce (Aerospace) and JCB, to name but a     over 178 coun-tries worldwide. Exports
                                                                                                                          of the UK’s overall exports
    few.                                                      increased by 38% between 2010 and 2013
    The Midlands Engine has over 1,200 life sciences

                                                                                                                                                                         Broad Street, Birmingham, courtesy of the © West Midlands Growth Company
    businesses supporting over 33,000 high skilled jobs. Of
    the 5.2 million people working in the Midlands Engine,
    41.6% are in knowledge intensive sectors.                 Stable population                                        It is recognised that the Midlands Engine is
                                                                                                                      home to a large, ethnically diverse and stable
    The Midlands Engine links the UK to the rest of the                                                               population with the largest non-white British
    world through its network of freight and passenger                                                                population outside of London. This large and
    airports, and connects the country through its road       Large, ethnically diverse and                           stable, diverse ethnic population and
    network and rail links. 90% of all UK businesses are                                                              demographic mix provides a perfect platform
    within 4 hours’ drive from the Midlands.                  stable population                                       for medical research and clinical trials
    The Midlands has a rich set of research and innovation
    assets. Home to 20 Universities, with 2 of these in the
    Top 15 UK Universities, supported by a network of 40
    Further Education Colleges, the 2014 Research
    Excellence Framework found world leading research in      The Midlands Engine has 6 medical schools; each             14%
    281 University departments. One of our Midlands           benefiting from proximity to, and close working with,
    Engine Universities ranks in the UK top 10 for            NHS Trusts. 1 in 7 (14%) of the UK's Medical Schools
    research power.                                           are based in the Midlands.                                  14% of all UK Medical
    The Midlands Engine contributes over £200 billion a
                                                                                                                          Schools are based in the
    year to the UK economy, with a fifth of all UK                                                                        Midlands
    manufacturing jobs being based in the Midlands.
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
Driving Life Sciences Business                                                                                                                                                Driving Life Sciences Business                             6

Why locate here
                  s                 s                              Skills Base

The Midlands Engine is home to extensive research and
                                                                   • A knowledgeable and collaborative life sciences skills
                                                                   • 20-29 year olds are the largest demographic group
                                                                                                                                     52       NHS Trusts     21   Innovation Centres            2       Airports
                                                                                                                                                                                                        including one 24 Hr Air
                                                                                                                                                                                                        Freight Airport
development facilities, as well as one of Europe’s largest and     • Around 5.2million people (15.9 ) In the Midlands are in
                                                                                                                                     • 42 Clinical                                                      Terminal

most diverse populations.                                            employment, with 41.6 judged to be in knowledge
                                                                     intensive sectors.                                                Commissioning
The availability of land and development opportunities within      • 33,964 highly skilled jobs in life sciences                       Groups                       Universities

the region for companies looking to expand or invest in the life   • 46,111 A level students in the Midlands Engine                                                 with 18 out of 20
sciences sector and take advantage of accelerated clinical         • Percentage of students achieving grades AAB or better           • 10 Sustainability            Universities
programmes, along with an established and well-connected life        at A level: 15.1
                                                                                                                                                                                                         Rail freight terminals
sciences community, provides exciting opportunities to new
                                                                                                                                       and                          offering courses
and existing businesses. This, combined with state of the art      Clinical trials                                                     Transformation               connected to
clinical and global healthcare facilities, drives strong
                                                                                                                                       Partnerships                 health
collaboration between academia, industry and health to give
the region’s
                                                                    • 86 Clinical Trial facilities - one in five uk Clinical Trial
                                                                      Facilities are in the Midlands and the Midlands has              (22.7 of UK                                                  1    UK’s largest cargo
life sciences industry a competitive advantage. For companies
operating on a global level, the Midlands Engine is a catalyst
for extending supply chains and a key to long term growth.
                                                                    • Unique population a large and stable, diverse ethnic
                                                                      population and demographic mix provides a perfect
                                                                      platform for medical research and clinical trials (largest
                                                                                                                                     • Serving a footprint
                                                                                                                                                             7     Enterprise ones
                                                                                                                                                                   within easy reach
                                                                                                                                                                   of the motorway
                                                                                                                                                                                                         tonnage port

                                                                      non-white British population outside of London)                  of over 10 million          network and
Connectivity & Accessibility                                                                                                           people                       Airports
                                                                    • The Midlands has more clinical trial facilities than any
                                                                      other English region
At the heart of road and rail infrastructure, the Midlands
strategic road and rail networks such as the M6, the M1, the
West Coast Mainline, the East Coast Mainline, and the                                                                                                                          Liveability & Affordability
Midlands Mainline are all of national importance. The East
                                                                                                                                                                               • Wide range of residential properties available in a mix
Midlands Gateway project provides a Strategic Rail Freight                                                                                                                       of urban and rural locations
Interchange with up to 6 million sq ft of new distribution and                                                                                                                 • Average house price 213,481 (London 625,817 /
storage buildings, built next to the UK’s only 24 hour Air                                                                                                                       South East (Oxford) 412,125 / East of England
Freight Terminal airport with links to the motorway network                                                                                                                      (Cambridge)
allowing goods to be shipped easily anywhere across the UK,                                                                                                                    • 315,176). (Source: Rightmove, 28/02/2020)
an import and export advantage.
                                                                                                                                                                               • Region boasts Areas of Outstanding Natural Beauty such
                                                                                                                                                                                 as the Peak District and the Cotswolds
Manufacturing & Supply Chain                                                                                                                                                     Cost of living on average 22 lower than London, 22
                                                                                                                                                                                 lower than the South East (Oxford), 10 lower than the
 • The Midlands has a strong advanced manufacturing and                                                                                                                          East of England (Cambridge) and 10 lower than the
   engineering base which employs 614,000 people and                                                                                                                             national average
   accounts for one fifth of the UK’s manufacturing
   employment.                                                                                                                                                                 Infrastructure & Capacity
 • 664 core medical technologies businesses and a further
   313 associated service and supply businesses 23 of
                                                                                                                                                                               • Wide range of accommodation available from new build
   the UK total.
                                                                                                                                                                                 to established research & development facilities
                                                                                                                                                                               • 1209 life sciences & healthcare businesses
                                                                                                                                                                               • 9 Growth Hubs


                                                                                                                                                                                                                                            Science Park Nottingham
                                                                                                                                                                               • 18 out of 20 Universities offer courses connected to
                                                        s                  s                                                                                                   • 6 Schools of Medicine
                          s                     ss          s                                                                                                                  • Midlands Engine Institutions secured over 20   of all UK
                                                                                                                                                                                 Research Council Funding in 2019, over 246m.
                                                                                                                                                                               • World-leading research in 281 University departments
                                                                                                                                                                               • 666 Secondary Schools - 15.1 achieve AAB or better
                                                                                                                                                                                 at A Level
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
7                     Driving Life Sciences Business                                                                                                                                                                   Driving Life Sciences Business             8

    Strengths of
    the Midlands
    The Midlands Engine offers an unparalleled blend                                                                               Clinical Collaborations
                                                                                                                                                                                                           Business Support
    of businesses, Universities and research translation                                                                           The region’s two Academic Health Science Networks (AHSNs)
                                                                                                                                                                                                           Medilink Midlands
    centres, coupled with strong collaboration, research                                                                           lead, catalyse and drive co-operation and productivity between
                                                                                                                                   Academia, Industry, Health and care providers and commissioners         The Life Sciences Industry Association, with

    and clustering activities which combine to make an                                                                             and citizens, helping to accelerate the adoption of innovation to
                                                                                                                                   generate continuous improvement in the Midlands Engine health and
                                                                                                                                                                                                           offices in both East and West Midlands,
                                                                                                                                                                                                           supporting the regions Life Sciences Sector for
                                                                                                                                   wealth. They both have specific Themes and Priorities in which
    established and well-connected eco-system.
                                                                                                                                                                                                           over a decade
                                                                                                                                   Clinical, Academia and Industry collaborate in order to provide
                                                                                                                                   solutions to health and social care challenges. Three solutions that
                                                                                                                                   have evolved to address these challenges with clinical and industry
    The Midlands Region is home to notable high growth                                                                                                                                                                    Life sciences & healthcare
    compan-ies indigenous to the Midlands, including the
                                                                    Academic Collaborations                                        collaborations are:
                                                                                                                                                                                                                          businesses within the Midlands
    Binding Site, Salts Healthcare, Quotient Sciences,                                                                             SCRIPT Medicines Management - To address the training need                             Engine Region
    Sygnature Discovery, Charnwood Molecular, Kimal Plc,            Midlands Innovation (www.midlandsinnovation.org.uk)            relating to medicines management and medicines optimisation, an
    Pennine Healthcare, Alliance Medical, Biocomposites,                                                                           eLearning programme for nurses was developed, based on the
    Thea Pharmaceuticals, and XenoGesis.                            A collaboration of eight research-orientated Universities
                                                                    (Aston, Birmingham, Cranfield, Keele, Leicester,               established successful SCRIPT programme for Foundation trainee
    Alongside these local companies, there are established
    multinationals including Parexel, McKesson UK, Clinigen
                                                                    Loughborough, Nottingham, and Warwick) combining their
                                                                    collective excellence to unite the power of University
                                                                                                                                   doctors. Partner Organisations: University of Birmingham; Coventry
                                                                                                                                   and Warwickshire Partnership NHS Trust; Health Education England.       £246 m
    Group, Worldwide Clinical Trials, 3M, Fresenius Medical         research with the unique strengths of Midlands industry to                                                                             With 20 Universities, Midlands Engine
    Care, Catalent Pharma Solutions and Walgreens Boots             drive cutting-edge research, innovation and skills             Atrial Fibrillation - AF Advance Programme - Atrial Fibrillation (AF)
                                                                                                                                   is one of the most common forms of abnormal heart rhythm and a          Institutions secured over 20% of all UK
    Alliance. This sub-sector is further strengthened by the        development.
                                                                                                                                   major cause of stroke. Working with CCGs, the EMAHSN has                Research Council Funding in 2019, over £246m.
    expansion of Almac with the move from their Northern
    Ireland Headquarters on to the Charnwood Campus in                                                                             engaged with healthcare professionals to put in practices new
                                                                       3 Midlands Innovation Universities are in the Top
                                                                                                                                   approaches to improve diagnosis and treatment. Since the launch of
                                                                                                                                                                                                           £4 bn
    Leicestershire, as well as by the move of Abbott                   100 QS World University rankings.
    Healthcare from Stratford to Solihull.                                                                                         the project 896 devices have been deployed to participating
                                                                                                                                   practices and support services in the East Midlands to increase
                                                                       4 noted in the top 20 for the                               detection and protection rates. The AF Advance Programme has
    The further success of local companies can also be                 2020 The Complete University Guide.                                                                                                 Midlands Enterprise Universities
    evidenced through the healthy level of company                                                                                 seen an increase in detection with an additional 6,247 people           collectively contribute more than £4
    acquisitions.                                                                                                                  diagnosed with AF in 2018/19 and an additional 5,510 East Midlands
                                                                       The 8 Midlands Innovation Universities generated                                                                                    billion to the region’s economy
                                                                                                                                   patients being treated for AF (2018/19). On average this has
                                                                       £550m in consolidated research grants and                   contributed to 220 people avoiding a stroke and a reduction of 73
    Of the 38 UK local Enterprises Partnerships (LEPs), 9 are          contracts in one year.
    located in the Midlands Engine. LEPs provide a range of
    activities and
                                                                       10% of all UK postgraduate students are at
    services with the aim of adding significant value to local
                                                                       Midlands Innovation Universities                            The Transfer of Medicines Programme aims to implement a process
                                                                                                                                   that can facilitate the safe transfer of medicines at both the          The Midlands Engine's 6 Medical Schools
    delivery and maximising the collective impact of the Midlands
                                                                    Midlands Enterprise Universities                               interface and handover of care. The process will support the            account for 14% of the UK total.
    Engine. To facilitate enterprise development they operate:
                                                                    (www.midlandsenterpriseuniversities.co.uk)                     medicines reconciliation process to reduce medication-prescribing
     • Growth Hubs                                                                                                                 errors. Partner organisations: University Hospitals Birmingham NHS      10 Universities train Midwives; 11 Universities
                                                                    A partnership of seven entrepreneurial Universities            Foundation Trust; Heart of England NHS Foundation Trust; Pfizer         train Nurses; 15 regional Universities offer
     • Enterprise Zones
                                                                    (Birmingham City, Coventry, Nottingham Trent, Derby,           Ltd. Additionally 3,063 patients in the East Midlands have received     clinical related & professions allied to
     • European Structural and Investment Funds Programmes          Lincoln, Wolverhampton and De Montfort) working together       extra support with their medicines on discharge.                        medicine courses
                                                                    to drive productivity and economic growth across the
    There are 21 Midlands innovation centres dedicated to
                                                                    Midlands through skills, innovation and enterprise have come   The regional AHSNs are engaging with industry to facilitate Digital
    speeding up the growth and success of start-up and early-
                                                                                                                                                                                                           £3.9 bn
                                                                    together to:                                                   Health and healthcare innovations by providing advice and support
    stage companies. In 2017/18, Innovate UK awarded Grant
    Funding totalling £300m to the Midlands, representing           • Enable innovation and to stimulate an innovation             around Clinical Trials, Evaluation, IP Protection, Market
    over 25% of the UK Total.                                       • ecosystem Deliver focused support to Midlands Engine         Entry,Adoption, Inward Investment and Wealth Creation.
                                                                       Small and Medium sized businesses (SMEs)                                                                                            Industrial R&D is core to the Midlands Engine.
                                                                     • Provide multi-billion-pound investment into new                                77 private hospitals                                 Businesses invested over £3.9 billion in R&D in 2017
                                                                       facilities for students and businesses                                                                                              with 47,000 employees engaged in R&D activity
                                                                                                                                                      159 NHS Hospitals
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
9              Driving Life Sciences Business                                                                                                                                Driving Life Sciences Business                                                                                     10

    Strengths                                                                                                                                                A critical emerging sector for the Midlands is Data-
                                                                                                                                                             driven Healthcare and Digital Healthcare, with the

    of the Midlands
                                                                                                                                                             region hosting a rapidly-growing cluster of digital health
                                                                                                                                                             companies and more digital start-ups than any UK area
                                                                                                                                                             outside of London. The Midlands also attracts global
                                                                                                                                                             companies to relocate here through our distinctive
                                                                                                                                                             NHS-partnering ecosystem, cutting-edge facilities and
                                                                                                                                                             world-leading expertise, as well as critical focal sites
                                                                                                                                                             including two UK Life Science Opportunity ones
                s Region                  s                               s       ss s          s      s                                                     (Charnwood Campus and Birmingham Life Science
                                                                                                                                                             Park). The Midlands is a health data and AI powerhouse,
       s             s                          s            s                                  s                                                            as recognised by the UK Sector Deal. Within this area,
        s                        s                                    s       s                                                                              there are two concentrations of activity:
                    s s                                                                                                                                           elerating isease o use in ustrial resear
                                                                                                                                                             Utilising close relationships between academic/clinical
                                                                                                                                    s                        excellence and ethnically diverse population, and world-
                                                                                                                                                             leading data scienceexpertise, the Midlands environment
                                                                                                               The Catapult Centres are a network of world   delivers the unparalleled opportunity to reduce
                                                                                                               leading centres designed to transform the     development time and costs of clinical trials to innovate
                                                                                                               UK’s capability for innovation in specific    faster. This is demonstrated through our regional

                                                                                                                                                                                                                 Value Manufacturing Catapult Centre, cou tesy of © Homes and Communit Agency
                                                                                                               areas and help drive future economic          infrastructure including: the UK’s only Centre for
                                                                                                               growth.                                       Patient Reported Outcomes, the Midlands HDRUK
                                                                                                                                                             Substantive Site, the Centre for BME Health, the
                                                                                                                              Medicines Discovery            Midlands-Wales Advanced Therapy Treatment Centre,
                                                                                                                              Catapult laboratory - A new    two UK Digital Innovation Hubs
                                                                                                                              innovative Medicines           (participating in a third), a fully integrated NIHR
                                                                                                                              Discovery Catapult facility    infrastructure
                                                                                                                                                                          coordinated by the three Midlands
                                                                                                                              targeted at developing new     Biomedical Research Centres, and some of the UK’s
                                                                                                                              complex biological assays      foremost diagnostic and experimental medicine
                                                                                                                              and advanced biochemical       capabilities (e.g. the UK’s largest NHS genetics service,
                                                                                                                              analysis.                      Genomic Medicine Centre and NIHR award for the joint
                                                                                                                                                             adult-paediatric facilities). All working collaboratively
                                                                                                                              High alue Manufacturing        with companies to develop technologies that support
                                                                                                                              Catapult                       prevention, early diagnosis and treatment of chronic
                                      s                The region is home to the largest number of                            H M is the application of
                                                       MedTech service and supply companies and also                          leading edge technical
                                                       home to over 20 of the UK’s manufacturing                              knowledge and expertise to       eli ering unri alle igital in rastru ture To support
                          s                            employment which provides 614,000 UK                                   the creation of products,      collaboration, mobilise NHS data and give patients
                                                       manufacturing jobs. This market is fed by a highly-                    production processes, and      across the UK faster access to pioneering new
                                                       skilled talent pool and links to vibrant, world-class                  associated services.           treatments, the region has developed a locally
                                  s                    research bases such as the four ‘Catapult’ centres                                                    developed and internationally leading digital health
                                                       that bring together clinicians, scientists, engineers                                                 infrastructure. This features two Alan Turing Institute
     The Midlands Engine is the epicentre of           and business to evolve medicines, manufacturing,                                                      sites, four NHS England Global Digital Exemplars, the

                                                                                                                                                                                                                 Ansty Park, Coventry - H
     advanced manufacturing and engineering in         transport and energy systems. The Manufacturing                                                       High Performance Computing Midlands Plus centre, the
     the UK, including innovative leaders in digital   Technology Centre (MTC) in Coventry is part of the                                                    PathLake Centre of Excellence, one of the world’s
                                                                                                                              Energy Systems Catapult
     and collaborative production processes. Its       High alue Manufacturing Catapult group and                                                            largest Arm-based supercomputer deployments and the
                                                                                                                              Transformation of our whole
     extensive supply chain is reshaping chemicals,    develops innovative manufacturing processes and                                                       UK’s largest IBM Power9 AI cluster. The Midlands offers
                                                                                                                              energy system and capture
     base and fabricated metals, electrical items,     technologies to support a range of manufacturing                                                      an unrivalled ability to link and analyse patient data,
                                                                                                                              the new commercial
     prefabrication and subcontracting including       sectors across the region and further afield.                                                         leverage our translational research infrastructure to
                                                                                                                              opportunities created
     machinery for Life Sciences as well as other                                                                                                            trial and validate new health interventions, and bring
                                                                                                                              (covering electricity, heat
     sectors.                                                                                                                                                those impacts back to the patient (as well as our
                                                                                                                              and combustible gases).
                                                                                                                                                             industry collaborators) at sufficient scale and pace to
                                                                                                                                                             meet the Grand Challenges set by the UK Industrial
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
11                     Driving Life Sciences Business                                                                                                                                                                     Driving Life Sciences Business                 1

     Core Life Sciences
            s         ss           s                    s

      The Midlands region has six Medical Schools each                  Clinical Business Support Centres
     benefiting from proximity to, and close working with
     Hospital Trusts. The number of Medical Schools in the              The Midlands Engine skills base makes it the go to
     Midlands represents 14 of all Medical Schools in                   location for organisations who want to develop diverse

                                                                                                                                                                                                                                                                         Science Park Nottingham
     England. This is also reflected in the scale of our                and dynamic partnerships between businesses,
     regional training capacity in science and engineering.             academia, suppliers and customers. The region is further
     Our Medical Schools are now working together with                  poised to capitalise on its ecosystem of assets to create
     other key stakeholders as the ‘Midlands Health                     a globally significant resource for the life sciences
     Innovation’ group.                                                 industry, bringing together industry with clinical,
                                                                        scientific and academic excellence across an integrated
                                                                        medical and life sciences community. The Midlands
     Significant strength cross-region                                  Engine has several well-established life sciences
     The region has significant strength in clinical trials in          locations. These clusters offer instant networks, access
     terms of both infrastructure and expertise - the                   to professional services, academia, industry support and

     Institute of Translational Medicine (ITM) and the                  funding.
     Birmingham Centre for Clinical Trials, with specific
     expertise in the design and running of medical device              Below we highlight a few of the non-commercial
     trials (D3B team) and high accrual rates. One of                   facilities. ngham’s Patient Reported Outcomes Centre).                                                                                                      s                s
     Europe’s largest academic trials infrastructures,
     together with the Leicester, Nottingham, Warwick
     and Derby Clinical Trials Units, amounts to a                                                                                                                                                                          The NCSEM-EM aims to apply world-
                                                                                                                                                                                                                            class expertise to policies and practice
     significant proportion of the UK’s clinical trials
                                                                                                                                                                                                                            that will benefit the health and
     capability.                                                                                                                                                                                                            wellbeing of the nation from everyday
                                                                                                                                                                                                                            people at risk of ill health through to

                                                                                                                                                                                                                            elite athletes.

     1                                                                                       3
                                                                                                                                                                                                                            Evidence shows that sport, exercise

           s                                                                                          s
                                                                                                                 s               s
                                                                                                                                          4          s
                                                                                                                                                                                                                            and physical activity are effective in the
                                                                                                                                                                                                                            prevention, treatment and
                                                                                                                                                                                                                            management of disease and can
           s                                                                                         s                                                                                                                      enhance mental health and wellbeing,
                                                                                                                                                                                     CHEATA was set up within the

                                                                                                                                          Birmingham Health Partners (BHP)                                                  reducing the risk of mental illnesses
                                                                                             The East & West Midlands CRN’s (Clinical     transcends organisational                  Department of Clinical                 such as depression, dementia and
     The Birmingham Institute of                            s       s              s         Research Networks) are two of the 15         boundaries to rapidly translate            Engineering at NUH NHS Trust in        Al heimer’s. The NCSEM-EM will build
     Translational Medicine aims to                         s                                                                             healthcare research findings into          response to the challenge laid out     on this evidence in four key research
                                                                                             regional networks within England which
     promote specific interactions                                                                                                        new diagnostics, drugs and devices         in Innovation Health and Wealth        areas which will be translated into
     across disciplines and with industry                                                    form part of the National Institute for
                                                 Two key organisations working                                                            for patients. It is a strategic alliance   - Accelerating Adoption and            teaching and training through our
     to accelerate development of                                                            Health Research (NIHR). The CRNs are
                                                 across all areas of the Midlands                                                         between the University of                  Diffusion in the NHS to help the       educational programmes and the
     innovations into concepts and                                                           funded by the Department of Health,
                                                 Engine that strive to bring Academia,                                                    Birmingham and two NHS                     NHS become the best health             clinical services we offer.
     assets that directly benefit                Business and Clinicians together are        and are the clinical research delivery arm                                                                                     The NCSEM-EM is one of three hubs
                                                                                                                                          Foundation Trusts Birmingham               system in the world by rapidly
     healthcare. It brings together              the East & West Midlands AHSNs,             of the NHS. As part of the wider NIHR,       Women’s & Children’s, and                                                         forming the National Centre for Sport
     people with relevant skills from            who are there to generate, interface        the Network provides infrastructure to                                                  adopting new devices and               and Exercise Medicine, along with
                                                                                                                                          University Hospitals Birmingham
     different disciplines, such as              and support interactions for Clinical       support clinical research in the NHS,                                                   technologies into practice.            London and Sheffield. The East
                                                                                                                                          where members collaborate to
     cancer, inflammation, rare diseases         excellence and economic growth              giving patients access to new treatments.    bring healthcare innovations               CHEATA is hosted by Clinical           Midlands hub is a partnership between
     and bioengineering, and provides            through their research support,             Their priority is to proactively support     through to clinical application. Its       Engineering service at                 the University of Leicester,
     infrastructure, such as informatics,        adoption of technology and                  the Life Sciences industry to deliver high   unique ecosystem enables the full          Nottingham University Hospitals        Loughborough University, The
     biorepositories and a stratified            signposting services to specific                                                         spectrum of translational medicine:        NHS Trust.                             University of Nottingham, University
                                                                                             quality clinical research in the NHS, and
     medicine laboratory, to speed up            regional clinical and business                                                           encompassing health data an                                                       Hospitals of Leicester NHS Trust and
     the translation of new discoveries
                                                                                             to enable this they have developed a
                                                 expertise and assistance.                   range of free services and support tools.    established local health system                                                   Nottingham University Hospitals NHS
     into health applications.                                                                                                            academic excellence and an                                                        Trust.
                                                                                                                                          extensive clinical trials capability.
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
13         Driving Life Sciences Business                                                                                                                                   Driving Life Sciences Business                 14

     Core Life Sciences                                                           Regional Centres of Clinical Research Excellence

     Business Resources                                                             • Advanced Therapies Facility (University of Birmingham)
                                                                                    • Anthony Nolan Cell Therapy Centre (Nottingham Trent
                                                                                                                                                         • Medical Technologies Innovation Facility (MTIF) (Nottingham
                                                                                                                                                           Trent University)
                                                                                        University)                                                      • MindTech Healthcare Technology Co-operative
                                                                                    • Arden Tissue Bank (University Hospital Coventry)                     (Nottinghamshire Healthcare NHS Foundation Trust)
                                                                                    • Birmingham University Imaging Centre (University of                • MindTech national centre for mental healthcare and dementia.
                                                                                        Birmingham)                                                      • Motion and Performance Centre (MPC) (University of
                                                                                    • Cancer Research UK Birmingham Centre (University                     Worcester)
                                                                                        Hospitals Birmingham)                                            • MRC Arthritis Research UK Centre for Musculoskeletal
                                                                                    • Cancer Research UK Clinical Trials Unit (University of               Ageing Research (University of Birmingham)
                                                                                        Birmingham)                                                      • National Pollen Research and Aerobiology Centre – Darwin
                                                                                    • Cancer Research UK Experimental Cancer Care Medicine                 Centre (University of Worcester)
                                                                                                                                                         • NHS Blood and Transplant Service (NHSBT) (University
                                                                                        Centre (University of Birmingham)
                                                                                                                                                           Hospitals Birmingham)
                                                                                    •   Centre for Analytical Science (Loughborough University)
                                                                                                                                                         • NHS Global Digital Exemplar (University Hospitals
                                                                                    •   Centre for Biological Engineering (Loughborough University)
                                                                                    •   Centre for Biomolecular Sciences (University of Nottingham)
                                                                                                                                                         • NIHR Applied Research Collaboration East Midlands
                                                                                    •   Centre for Clinical Haematology (University Hospitals
                                                                                                                                                         • NIHR Applied Research Collaboration West Midlands
                                                                                        Birmingham)                                                      • NIHR Biomedical Research Centre in Inflammation
                                                                                    •   Centre for Computational Biology (University of Birmingham)      • NIHR Birmingham Clinical Research Facility
                                                                                    •   Centre for Healthcare Technologies (University of                • NIHR Coventry and Warwickshire Clinical Research Facility
                                                                                        Nottingham)                                                      • NIHR Global Health Research Group on Global COPD in
                                                                                    •   Centre for Healthcare Technology Assessment (CHEATA),              Primary Care (University of Birmingham)
                                                                                    •   Centre for Patient Reported Outcome Research (CPROR)             • NIHR Global Health Research Unit on Global Surgery
                                                                                    •   Centre for Prognosis Research (Keele University)                   (University of Birmingham)
                                                                                    •   Centre for Rare Diseases (University Hospitals Birmingham)       • NIHR Leicester Biomedical Research Centre - Respiratory,
                                            The Midlands Engine region              •   Centre for Translational Inflammation Research (University of      Lifestyle, Precision Medicine & Cardiovascular (University
                                                                                        Birmingham)                                                        Hospitals of Leicester NHS Trust, University of Leicester and
                                            is a distinctive UK centre for          •   Centre for Vision & Hearing Research (Aston University)            Loughborough University)
                                                                                    •   Centre of Precision Rehabilitation for Spinal Pain (University   • NIHR Leicester Clinical Research Facility
                                            clinical trials, and research and           of Birmingham)                                                   • NIHR Nottingham Biomedical Research Centre - Respiratory,
                                                                                    •   Clinical Immunology Service (University of Birmingham)             Mental Health & Technology, Musculoskeletal, Hearing,
                                            development, having a wealth            •   East Midlands Congenital Heart Centre (University Hospitals        Gastrointestinal & Liver and MRI Imaging (Nottingham
                                                                                                                                                           University Hospitals NHS Trust and the University of
                                            of experience across a wide             •
                                                                                        of Leicester NHS Trust)
                                                                                        Elite Centre for Manufacturing Skills (The Black Country LEP,      Nottingham)
                                                                                                                                                         • NIHR Nottingham Clinical Research Facility
                                            range of diseases, conditions           •
                                                                                        West Midlands)
                                                                                        EPRSC Centre for Innovative Manufacturing in Regenerative        • NIHR Surgical Reconstruction and Microbiology Research
                                            and clinical settings, all of which         Medicine (Loughborough University)
                                                                                                                                                         • NIHR Trauma Management MedTech Co-operative
                                                                                    •   EPSRC and MRC Centre for Doctoral Training in
                                                                                                                                                         • NIHR Wellcome Trust Clinical Research Facility (University
                                            need specific trial designs to test         Regenerative Medicine (Keele University)
                                                                                                                                                           Hospitals Birmingham)
                                                                                    •   EPSRC and MRC Centre for Doctoral Training in
                                            and evaluate them accurately                Regenerative Medicine (University of Nottingham)
                                                                                                                                                         • Phenome Centre Birmingham (University of Birmingham)
                                                                                                                                                         • Precision Medicine Institute (University of Leicester)
                                                                                    •   European Association for Cancer Research (University of
                                            and sufficiently. To facilitate the         Nottingham)
                                                                                                                                                         • Royal Centre for Defence Medicine (University Hospitals
                                                                                    •   European Centre of Excellence in Tissue Engineering (Keele
                                            needs of Industry and to satisfy            University)
                                                                                                                                                         • Science, Technology and Prototyping Centre (Black Country
                                                                                    •   Health Services Management Centre (University of
                                            their regulatory requirements               Birmingham)
                                                                                                                                                         • Tommy’s National Centre for Miscarriage Research
                                                                                                                                                           (University of Birmingham and Birmingham Women &
                                            in order to bring ideas and             •
                                                                                        Henry Wellcome Building for Nuclear Magnetic Resonance
                                                                                        Human Biomaterials Resource Centre (University of
                                                                                                                                                           Children’s Hospital)
                                                                                                                                                         • Transplant Unit Cardio-Thoratic, Liver, Kidney (renal), and
                                            concepts to market, the region          •
                                                                                        Insitute for Mental Health (University of Birmingham)
                                                                                                                                                           Intestinal (University Hospitals Birmingham)
                                                                                                                                                         • Transplant Unit Kidney (renal) (City Hospital, Nottingham)
                                            has evolved a wide range of             •   Insitute for Mental Health (University of Nottingham)            • Transplant Unit Liver (Birmingham Children’s Hospital)
                                                                                    •   Institute of Digital Healthcare (University of Warwick)          • UK’s National Sperm Bank (Birmingham Women’s Hospital)
                                            industry medical support                •   John Van Geest Cancer Research Centre (Nottingham Trent          • West Midlands Genomics Medicine Centre (University
                                                                                        University)                                                        Hospitals Birmingham)
                                            organisations, both public sector       •   Keele Anatomy and Surgical Training Centre (Keele                • West Midlands Regional Genetics Laboratory (Birmingham
                                                                                        University)                                                        Women and Children’s Hospital)
                                            NHS and Academic as well as             •   Leicester Bone Bank (University Hospitals of Leicester)
                                                                                    •   Leicester Precision Medicine Institute (University of
                                            commercial.                                 Leicester)
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
1                                                         Driving Life Sciences Business                                                                                                  Driving Life Sciences Business                  16

                                                                                 Trauma & Defence Medicine                      Major Trauma - Civilian
                                                                                                                                East Midlands Major Trauma Centre (EMMTC) –                     University Hospitals Birmingham (UHB) -
                                                                                                                    s   s   s   Nottingham University Hospitals NHS Trust                       Major Trauma & Critical Care
                                                                                                                                                      Since the East Midlands Major Trauma
                                                                                                                                                      Centre (MTC) opened in April 2012,                                           The Queen Eli abeth Hospital
                                                                                                                                                      645 lives have been saved that
                                                                                                                                                                                                Birmingham (QEHB) has the largest single Critical Care Unit in
                                                                                                                                without the advanced skills and interventions received would    Europe, with 100 bed spaces. To date 75 of these are open.
                                                                                                                                otherwise not be expected to survive their injuries. The East   Critical Care provides 24/7 treatment to adults, in a separate
                                                                                                                                Midlands MTC is the busiest in the country and has the          and self-contained area of the hospital. It is dedicated to the
                                                                                                                                strongest clinical outcomes nationally.                         management and monitoring of patients with life threatening
                                                                                                                                                                                                conditions. It provides specialist skills which include medical,
                                                                                                                                                                                                nursing and other personnel experienced in the management of
                                                                                                                                                                                                these patients. UHB are specialist providers of a wide range of
                                                                                                                                                                                                disciplines which include neurosurgery, burns, liver surgery,
                                                                                                                                                                                                oncology, cardiac surgery, transplants and organ donation,
                                                                                                                                                                                                plastic surgery, dermatology, maxillofacial, renal surgery,
                                                                                                                                                                                                stroke, vascular surgery and urology.

                                                                                                                                                                                                The Robert ones and Agnes Hunt
                                                                                                                                                                                                Orthopaedic Hospital NHS Foundation Trust
                                                                                                                                                                                                (R AH)
                                                                                                                                                                                                                                     The Robert ones and
                                                                                                                                University Hospitals                                                                                 Agnes Hunt Orthopaedic
                                                                                                                                Coventry & Warwickshire – MTC                                                                        Hospital NHS Foundation
                                                                                                                                                                                                Trust (R AH) is a leading orthopaedic centre of excellence. A
                                                                                                                                                          UHCW is proud to have been            specialist hospital with a reputation for innovation, the Trust
                                                                                                                                                          successfully re-certified as a        provides a comprehensive range of musculoskeletal (bone,
                                                                                                                                                           Centre of Excellence (CoE) for       joint and tissue) surgical, medical and rehabilitation services
                                                                                                                                                          Gastro-entero-pancreatic (GEP)        locally, regionally and nationally. R AH is a founder member
                                                                                                                                Neuroendocrine Services by the European                         of the Specialist Orthopaedic Alliance (SOA)
                                                                                                                                Neuroendocrine Tumour Society (ENETS). The Trust is
                                                                                                                                also delighted to have been newly certified as a CoE for        The Royal Orthopaedic Hospital NHS
                                                                                                                                Lung Neuroendocrine Tumours. Both of these                      Foundation Trust
                                                                                                                                accreditations highlight prestigious services and
Picture courtesy of the © West Midlands Ambulance Service NHS Foundation Trust

                                                                                                                                establish UHCW as a leading Trust in treatment for                           The Royal Orthopaedic Hospital NHS Trust in
                                                                                                                                patients in these areas.                                                     Birmingham is one of the largest orthopaedic
                                                                                                                                University Hospitals of North Midlands –                                     centres in Europe. The Trust offers planned
                                                                                                                                                                                                             specialist care for all of the orthopaedic
                                                                                                                                                      UHNM was the first acute NHS              subspecialties, from elective arthroplasty for local patients,
                                                                                                                                                      Trust to provide job planned pre-         through to regional and supra-regional services (for example
                                                                                                                                                      hospital time for trauma                  in spinal surgery and oncology).
                                                                                                                                                      anaesthetists and enter into a
                                                                                                                                                      formalised partnership
                                                                                                                                with pre-hospital providers to supply pre-hospital
                                                                                                                                emergency medicine consultants on a regular                       The Midlands Engine is the UK’s centre for
                                                                                                                                basis.UHNM receives patients from all across the North            Trauma & Defence Medicine, with the tri-
                                                                                                                                Midlands Staffordshire, Shropshire, Cheshire as well              service Royal Centre for Defence Medicine
                                                                                                                                as further afield from North Wales                                (RCDM) located at University Hospitals
                                                                                                                                Birmingham Children’s Hospital - Paediatric                       Birmingham NHS Foundation Trust in
                                                                                                                                                                                                  Birmingham, and the Headquarters of the
                                                                                                                                MTC                                                               Surgeon General together with the oint
                                                                                                                                                      Birmingham Children’s Hospital is
                                                                                                                                                      the UK’s leading specialist
                                                                                                                                                                                                  Medical Command at Lichfield. Completing
                                                                                                                                                      paediatric centre, caring for sick          the region’s unparalleled expertise, The
                                                                                                                                                      children and young people up to             new Defence Medical Rehabilitation
                                                                                                                                                      the age of 16.                              Centre known as ‘DMRC Stanford Hall’
                                                                                                                                Rated as ‘Outstanding’ by the CQC in February 2017, it is
                                                                                                                                                                                                  near Loughborough, started treating
                                                                                                                                a world leader in some of the most advanced treatments,           patients in October 2018.
                                                                                                                                complex surgical procedures and cutting-edge research
                                                                                                                                and development.
Driving Life Sciences Business In the UK Midlands Region - Medilink Midlands
17                                Driving Life Sciences Business                                                                                                            Driving Life Sciences Business                   18

                            Trauma & Defence Medicine

                                                                                          Royal Centre for Defence Medicine                                     Defence College of Healthcare Education
                                                                                          (RCDM)                                                                and Training (DCHET)
                                                                                                      Established in 2001, the RCDM’s primary role is           The Defence College of Healthcare Education and Training is
                                                                                                      the focal point for the reception of military             based at the Defence Medical Services (DMS) Whittington near
                                                                                                      casualties from overseas, providing a ‘front              Lichfield. It delivers individual medical training and education
                                                                                                      door’ from the battlefield into the NHS.                  to agreed standards and in accordance with current Defence
                                                                                                                                                                (including Reserves & Civil Service Clinical staff) policies, on
                                                                                          Nested within the Queen Elizabeth Hospital Birmingham                 behalf of the Royal Navy, Army and Royal Air Force.
                                                                                          (QEHB) , the RCDM supports the QEHB in its role as the
                                                                                          principal acute receiving hospital in the UK. It does this            It facilitates, through extensive relationships with Midlands-
                             The Midlands –                                               through the provision of military manpower and specialist             based and other academic institutions, all external DMS Medical
                             The Home of Military Medicine                                military expertise in order to facilitate the military patient care   Officer, General Practitioner, undergraduate Nurse and Allied
                                                                                          pathway.                                                              Healthcare Professionals specific training and education. In
                                                                                                                                                                addition, DCHET’s courses are distributed under licence and
                             The centre of gravity of Defence Medicine is now firmly      This means that while the NHS leads in the delivery of the            franchise on a global scale. This is achieved while maintaining a
                             established in the Midlands, with the Royal Centre for       clinical capability, it benefits from the co-location of the RCDM     strong military ethos, alongside military and physical
                             Defence Medicine located at University Hospitals             and its ability to enhance NHS services with, for example,            development, to deliver appropriately trained and prepared
                             Birmingham NHS Foundation Trust, and the Defence             military focused rehabilitation and occupational health for           military healthcare professionals.
                             Rehabilitation Centre, based at Stanford Hall Estate         military patients. In addition, the RCDM is able to reassign
                                                                                          military clinical staff to assist the NHS in the treatment of         The education delivered by DCHET supports military operations
                             near Loughborough since 2018. The Headquarters of
                                                                                          military patients when required.                                      worldwide, and the effects of its training have seen a positive
                             the Surgeon General and the Defence College for
                                                                                                                                                                impact on operational effectiveness.
                             Healthcare Education and Training are located at             Ideally, care should extend beyond the patient’s immediate
                             Defence Medical Services (Whittington), the site of the      clinical needs. As such, the RCDM is uniquely enhanced to             Providing 127 different courses to 8,600 students each year,
                             former Staffordshire Regiment Headquarters south of          provide medical administration and welfare support to military        DCHET is as unique is it is diverse. DCHET delivers over 40,000
                             Lichfield. Although the Defence Medical Services,            patients (and their families) admitted to the QEHB. This              high quality training days annually, facilitating training in a
                             comprising personnel from the Royal Navy, Army,              ‘military bubble’ concept is necessary for the well-being of the      professional, safe and compliant environment, which instils in its
                             Royal Air Force, and Civil Service, are spread widely        military casualty and forms a key component of our duty of            students a confidence in both their training and themselves and,
                             throughout the UK and overseas, the geographical             care to our wounded, ill and sick. It is also something that the      most importantly, an ability to deliver high levels of care
                                                                                          RCDM can provide to other NHS specialist hospitals if                 wherever and whenever they are required to do so.
                             focus of the components above consolidates the
                             region’s position as an international centre of
                             excellence for Defence Medicine.                             Finally, the RCDM also functions as a conventional Defence            Defence and National Rehabilitation Centre
                                                                                          Medical Group regional hub: military clinical staff maintain
                                                                                          their skill-sets in NHS Trusts across the UK including
                             Medical Directorate                                          Birmingham, Oxford, Stoke, Nottingham, Peterborough,
                                                                                                                                                                The DNRC programme is the late Duke of Westminster’s
                                                                                                                                                                vehicle to deliver his vision of a pan-Government
                                                                                          Cardiff and East Grinstead.
                             The Medical Directorate is located within the University                                                                           rehabilitation capability for Defence and the Nation, through
                             of Birmingham Research Park and is the home for                                                                                    the Black Stork Charity, on the Stanford Hall Estate near
                             military medicine Academic Departments and clinical                                                                                Loughborough. The establishment of the Defence component
                                                                                                                                                                of the DNRC provides a state-of the-art facility that will
                             expertise for UK Defence. The Directorate’s mission is
                                                                                                                                                                ensure the continued provision of world-leading rehabilitation
                             to improve patient care within Defence through                                                                                     for our sick and injured Service personnel. The Defence
                             Innovation, Research & Development, and Healthcare                                                                                 facility opened in 2018 and replaced the former Defence
                             Engagement, regionally, nationally and internationally.                                                                            Medical Rehabilitation Centre at Headley Court, Surrey.
                             The nine academic departments are Mental Health;
                             Nursing; General Practice and Primary Care;
                             Anaesthesia and Critical Care; Surgery; Medicine;
                             Trauma & Orthopaedics; Emergency Medicine; and
                             Military Rehabilitation. The Directorate has built a world
                             renowned reputation for trauma innovation following
                             recent campaigns in Afghanistan and Iraq. Current
© Crown copyright [2018].

                             health and health science research is focused on
                             rehabilitation of musculo-skeletal injury, prolonged care
                             (both pre-hospital and deployed hospital care) and
                             military mental health.
19                     Driving Life Sciences Business                                                                                                                                                                         Driving Life Sciences Business                   20

     Clinical Trials, Testing
                                                                                                                                    Clinical Trials
                                                                                                                                    The Midlands Engine is driving up business innovation and improving productivity and competitiveness. Our Universities
                                                                                                                                    and businesses work together to bring forward innovations that support our key sectors and their supply chains.

     and Research                                                                                                                   Regional NHS Trusts are conducting research for Blue Chip Multi-nationals together with leading national and
                                                                                                                                    international companies, such as:

                                                                                                                                        • AB Sciences                   • Bayer                            • Hoffman-La Roche                  • Parexel
                                                                                                                                        • Abbott                        • Boehringer Ingelheim             • INC Research                      • Pfizer
                                                                                                                                        • Abbvie                        • Boston Scientific                • Intel                             • PRA Health Sciences
     Clinical Services, Activity and                                  Midlands Engine NHS Centres                                       • Alexion                       • Bristol Myers Squibb             • Janssen-Cilag                     • Roche Products
     Facilities                                                       The 80+ Midlands Engine NHS centres that provide
                                                                                                                                          Pharmaceuticals               • Celgene Corporation              • Medimmune                         • Sandoz
                                                                      commercial research services also have a plethora                 • Allergan                      • Diiachi Sankyo                   • Medtronic                         • Sanofi-Aventis
     Midlands Engine NHS Trusts conduct a wide range of
                                                                      of facilities in which to support and facilitate their            • Amgen                         • Eli Lilly                        • MSD                               • Servier
     research work on behalf of and in association with               investigations and trials from; Imaging (MRI Scanning             • Arthrysys                     • Genentech                        • Novartis                          • Shire
     industry.                                                        to Dexa Scanning), Laboratory Work (Histology,
                                                                                                                                        • Astellas Pharma               • Gilead                           • Novo Nordisk                      • Sorin
                                                                      Pathology etc.) to Data Analysis and Health
     Last year regional health organisations conducted over                                                                             • AstraZeneca UK                • GSK                              • Onyx Therapeutics
                                                                      Economics. There are also 42 regional CCG (Clinical
     4,100 portfolio studies with over 136,000 patients and this      Commissioning Groups) that are conducting                         • Baxter Healthcare
     does not include the direct commercial work that was             community and delivery based studies - the majority
     performed for companies.                                         of which are portfolio work but some of these are
                                                                      engaged in commercial studies.
     Research undertaken for industry takes various forms
     related to patient care, outcomes and service delivery.
     These studies and trials can be: Clinical Trials of an
                                                                      Leicester Bone Bank                                           CRO’s & Product Testing Facilities
     Investigational Medicinal Product (CTIMPs) from phase I to
     IV, Human Factors Studies, Human Tissue Studies: tissue          Leicester Bone Bank is a bone and tissue bank which           There is a significant array of Clinical Research Organisations (CRO’s), product testing facilities and regulatory affairs organisations
     sample studies including the 100K Genome Project,                stores and supplies bones and other tissues to transplant
                                                                                                                                    within the Midlands Engine region to meet any life sciences organisations’ manufacturing or regulatory requirements; from
     Questionnaires and other Qualitative Studies, through to         surgeons all over the United Kingdom as well as for
                                                                      research. It is now the largest NHS hospital based tissue     materials and product testing to drug discovery and testing; and from laboratory to 1st in man clinical trials to provision of
     Research Database Studies such as de-nominalised NHS                                                                           completed regulatory certification.
                                                                      bank in the country. They collect bones from many
     patient data via specialist NHS centres such as the Clinical     hospitals across the country and supply surgeons
     Research Informatics Unit; Data to Knowledge Unit                throughout the UK and are regulated by the Department         Many of the Midlands Engine companies that support, facilitate and service the Life Sciences sector with testing and clinical trials
     (including the advanced IT link between the University of        of Health’s Human Tissue Authority.                           for validation and certification are listed below. These services can work with local regulatory experts and notifiable bodies to
     Leicester and UHL facilitating the utilisation of patient                                                                      provide the legal requirements to market products within the UK, Europe, USA and elsewhere within the world. These complement
     information for research).                                       100K Genome Project                                           the equally large number of University, NHS and hospital based trials and testing facilities, with additional healthcare and clinical
                                                                                                                                    industry related services.
                                                                      Midlands Engine Trusts have intensely embraced this UK
     Whilst the majority of the trials conducted within Midlands      project which has successfully sequenced 100,000              • Adkins Medical Market             • Crown Bioscience UK              • Paracelsis                       • Wolfson Labs
     Engine Trusts are for Pharmaceutical Studies there is a          genomes from around 70,000 people. To date, actionable            Research                        • Drugs with a Difference          • Parexel Informatics              • Worldwide Clinical Trials
     growing activity in Clinical Evaluation and Human Factors        findings have been found for 1 in 4/1 in 5 rare disease       • Alta Bioscience                                                                                         • WRK Design Services
                                                                      patients, and around 50% of cancer cases contain the                                              • Eady Project Services            • Peakdale Molecular Ltd
     work for medical devices, technology and systems by the                                                                        • Archimedes Development                                                                                    Ltd
                                                                      potential for a therapy or a clinical trial.                                                      • Fleming Polymer                  • Pepceuticals Ltd                 • XenoGesis Ltd
     Centre for Healthcare Technology Assessment (CHEATA),                                                                              Ltd                               Testing & Consultancy            • PharMomentum Ltd
     Nottingham and the recent Medical Device Technology                                                                            • Astrimmune                        • Food & Drug Analytical           • Pure Drug Safety Ltd             Regulatory Organisations
     Evaluation Centre (MD-TEC), Birmingham who lead much             Transplant Units                                              • Aurelia Bioscience                  Services Ltd
     of this work and activity together with many of the larger                                                                                                                                            • Pyrus Pharma Ltd                 • Advena Ltd
                                                                      There are 5 specialist Transplant Units within the region -   • BCM Specials (a member of         • Gammadot Rheology
     regional NHS Trusts.                                                                                                                                                                                  • Quotient Sciences Ltd
                                                                      these are: Queen Elizabeth Hospital, Birmingham -                                                 • Haemostatix Ltd                                                     • Birmingham Quality UK
                                                                                                                                        Alliance Boots)                                                                                         NEQAS
                                                                      Cardiothoracic, Liver, Kidney (renal) and Intestinal;                                                                                • RAPRA
     The region houses four Tissue Bank centres; Arden Tissue                                                                                                           • Histologix Ltd
                                                                      Coventry University Hospital – Kidney (Renal); Leicester      • Biopharma Stability                                                  • Reach Separations Ltd            • Formpipe Life Science
     Bank, based at University Hospitals Coventry &                                                                                     Testing Laboratory              • Ian Wilding Associates
                                                                      General Hospital – Kidney (Renal); Birmingham Children’s                                                                                                                • Lloyds Register Quality
     Warwickshire, which provides researchers with access to a                                                                                                                                             • Renasci Consultancy Ltd
                                                                      Hospital - Liver and City Hospital,Nottingham - Kidney        • Birmingham Health                 • Inocardia Ltd                                                         Assurance Ltd
     diverse range of high quality human tissue; the Human            (renal). These centres engage in various aspects of               Partners (BHP)                                                     • Retrogenix
                                                                                                                                                                        • Intelligent OMICS Ltd                                               • Medical Device
     Biomaterials Resource Centre (HBRC) Birmingham is a              research in relation to the safe removal (harvesting),        • Catalent Pharma Solutions                                            • Sequani Ltd
                                                                      transportation and transplantation of these organs and                                            • Lucideon                                                              Consultancy
     (HTA) licensed human sample biorepository with facilities                                                                          Ltd                                                                • Source Bioscience
     for: bespoke tissue collection, high quality storage space       tissue.                                                                                           • MD-TEC                                                              • Maetrics
                                                                                                                                    • CellAura Technologies Ltd                                            • Sygnature Discovery
     for large collections and access to archived diagnostic                                                                                                            • Medsyndesign Ltd
                                                                                                                                    • Cellomatics Biosciences                                              • TumorTrace
     fixed tissue blocks and associated data; Nottingham              The Anthony Nolan Cell Therapy Centre                             Ltd                             • Mercian Science Ltd
     Health Science Biobank (NHSB) provides a centralised,                                                                                                                                                 • Synexus Ltd
                                                                                                                                    •   Charnwood Molecular Ltd         • Morningside
     quality assured, biofluid and tissue resource to underpin                                                                                                            Pharmaceuticals                  • TRW Conekt
                                                                      The Anthony Nolan Cell Therapy Centre is based at the         •   CHEATA
     translational studies and adding value to clinical trials with   Clifton Campus of Nottingham Trent University. The                                                • National Pollen and              • TUV SUD Product
     a specialist area concerning Breast Cancer samples;              Centre processes and stores cord blood for national and       •   Chembiotech Laboratories                                             Service
                                                                                                                                                                          Aerobiology Research
     Leicester Biobank is equipped with robotic equipment             international clinical transplantation centres.               •   Clinigen                          Unit (NPARU)                     • Tyg Oncology
     capable of processing and storing biological samples from                                                                      •   Co-Formulate Ltd                • Neurosolutions Ltd               • Upperton Ltd
                                                                      The centre also carries out world-class research using
     up to 100,000 individuals.                                       blood of non-clinical standard, and supplies cord blood to    •   Critical Pharmaceuticals Ltd                                       • Winnats Scientific
                                                                      other approved research programmes throughout                                                                                          Services
2                       Driving Life Sciences usiness                                                                                                                                                                                                                                                                                     Driving Life Sciences usiness                      22

                                                                                                                                                                                                                                                                                                                                            22 & Growing
    Clinical Trials, Testing and Research                                                                                                                                                        Medical Supply Chain                                                                                                                       With changes to the Medical Devices
                                                                                                                                                                                                                                                                                                                                            Regulation and CE Marking there is growing
                                                                                                                                                                                                                                                                                                                                            demand and requirement for Regulatory
                                                                                                                                                                                                                                                                                                                                            matters and approvals. All the professions
    100 & Rising                                                                                                                         Leeds                                                                                       Leeds                                                                                                  that assist companies to bring their products
                                                                                                                                                                                                                                                                                                                                            to market and maintain market share are
    There are over 100 NHS based
                                                    NHS - Trials, Testing & Research                                                                                       Grimsby                                                                                    Grimsby
                                                                                                                                                                                                                                                                                             Professional Services                          here from Reg Affairs, IP Lawyers &
    organisations engaged in clinical research,                                                                        Manchester                                                                                 Manchester
                                                                                                         Liverpool                                                                                   Liverpool                                                                                Accountants & Tax Advisors                   Insurance Firms to Translation, Market
    with at least 1 commercial trial or                Acute Health Hospital                                                             Sheffield                                                                                  Sheffield
                                                                                                                                                                                                                                                                                              Advertising & Marketing                      Analysis, PR and Sales, everything needed
                                                       Ambulance Service
    evaluation being conducted by each                 Children’s Health Hospital                                                                                 Lincoln                                                                                    Lincoln                          Consultancies                                to ensure success.
    establishment. These organisations range           Community Health Hospital                                                                                                                                                                                                             Business Development / Support
                                                       Community Health Specialist Centre                                                                                                                                                                                                     Consultancies
    from Acute to Community Care through to
                                                                                                                                                                                                                                                                                                                                            20,000 Staff
                                                                                                                           Stoke on Trent                                        Boston                               Stoke on Trent                                        Boston
                                                        / Clinic                                                                               Nottingham                                                                                 Nottingham                                          Funding - VC’s, Angel, Finance
                                                                                                                                         Derby                                                                                      Derby
    the specialist Hospitals such as Children’s,       Dental Hospital                              Oswestry                                                                                    Oswestry                                                                                      & Investment Companies
                                                                                                                                                 Loughborough                                                                            Loughborough
    Women’s, Dental, Orthopaedics and                  Mental Health Hospital                                                                                                                                                                                                                Insurance Brokers - Medical                  12,000 people employed in the Midlands
                                                                                                         Shrewsbury                                                                                  Shrewsbury
                                                       Mental Health Specialist Centre/Clinic
    Trauma.                                            Ophthalmic Hospital                                     Wolverhampton
                                                                                                                                                                       Peterborough                         Wolverhampton
                                                                                                                                                                                                                                                                                               Technology/ Life Sciences                    are engaged in Life Sciences, ust over
                                                                                                                                                                                                                                                                                              IP & Legal Services                          10 making us the 2nd largest employer
                                                       Orthopaedic Specialist Hospital                                       Birmingham                                                                                 Birmingham
                                                                                                                                                                                                                                                                                              Market & Data Analysis Service /
                                                       Other Specialist Treatment -                                                   Coventry                Kettering                                                          Coventry                Kettering                                                                         of MedTech staff in the UK. The breadth
    0.25m Students                                  
                                                        Specialist Centre/Hospital
                                                        Trust Research Centre - Other                                 Worcester Stratford-upon-Avon
                                                                                                                                                                                     Cambridge                   Worcester Stratford-upon-Avon
                                                                                                                                                                                                                                                                                              Marketing & Sales Consultancy
                                                                                                                                                                                                                                                                                                                                            of employment and range and number
                                                       Women’s Health Hospital                                                                                                                                                                                                               Public Relations and Communication           of regional University graduates indicates
    Over 0.25 million students are taught by the                                                           Hereford                                                                                    Hereford
                                                                                                                                                           Milton Keynes                                                                              Milton Keynes
                                                                                                                                                                                                                                                                                               Consultants                                  the exceptional opportunities available to
    20 Universities within the Midlands Engine.                                                                                                                                                                                                                                               Regulatory Affairs Consultancies,            support the entire supply chain. For R&D
                                                                                                                                                                      Luton                                                                                      Luton
    18 Universities provide Medical and Life                                                                                                                                                                                                                                                   Notifiable Bodies & Quality Assurance 24     and manufacturing as well as businesses
    Sciences Courses, with 15 courses training      Commercial -                                       NHS - Trials, Testing & Research           Oxford
                                                                                                                                                                                                   Professional Services                     Oxford
                                                                                                                                                                                                                                                                                              Translation & Interpretation                 requiring professional consultancy
                                                    Trials, Testing & Research                                                                                                                                                                                                                Writer - Technical / Regulatory Info /
    health professionals (Doctors, Nurses,                                                                                                                                     London                                                                                     London
                                                        Clinical Test/Diagnostic Laboratory                                                                                                                                                                                                    Communication
    Midwives, Professions Allied to Health). 6
    Schools of Medicine possibly the greatest
    density of Medical Schools in the UK. A Rich
                                                        CRO Consultancy / Service
                                                        Industrial Test & Evaluation                                                                                                                                                                                                                                                        6m sq ft
                                                        Industrial Test & Evaluation -
    source of talent.                                   Quality Standards
                                                                                                                                         Leeds                                                                                      Leeds
                                                        Laboratory Services
                                                        Laboratory Technology                                                                                                                                                                                                                                                               Logistics and shipping into and across the
    159 / 52                                            R&D - Drugs / Vaccines / Diagnostics
                                                        / Biomarkers                                                   Manchester
                                                                                                                                                                                                                                                                      Grimsby               Manufacturing Services                          UK is being super enhanced. East Midlands
                                                                                                                                                                                                                                                                                                                                            Gateway provides a Strategic Rail Freight
                                                        R&D - Other                                      Liverpool                                                                                   Liverpool                                                                               Contract Manufacturer /
    There are 159 NHS Hospitals and 52 NHS              Research Engineering Design
                                                                                                                                          Sheffield                                                                                  Sheffield
                                                                                                                                                                                                                                                                                              Sub Assembly                                  Interchange which accommodates up to 6
    Trusts within the Midlands Engine region.           Consultancies                                                                                              Lincoln                                                                                    Lincoln                        End Product Distributor /                     million sq ft of distribution and storage
    With a number of Specialist Trusts such as                                                                                                                                                                                                                                                Supplier                                      buildings. uilt next to the UK’s only
                                                                                                                                                                                                                                                                                             Environmental Consultants /
    the Women’s (1 of only 4 in England) who                                                                               Stoke on Trent
                                                                                                                                               Nottingham                        Boston                               Stoke on Trent
                                                                                                                                                                                                                                          Nottingham                        Boston                                                          24 hour Air Freight Terminal Airport with
                                                                                                                                         Derby                                                                                      Derby                                                     Contractors
    also host the UK’s National Sperm ank, a                                                         Oswestry                                                                                    Oswestry                                                                                                                                   links to the motorway network with the
                                                                                                                                                 Loughborough                                                                            Loughborough                                        Industrial Design Consultancies
    modern, NHS based, fully-integrated donor                                                            Shrewsbury                                                                                  Shrewsbury                                                                              Lean Management /
                                                                                                                                                                                                                                                                                                                                            ability to ship goods anywhere in the UK.
                                                                                                                                                   Leicester                                                                                  Leicester
    recruitment, screening and banking centre                                                                   Wolverhampton                                          Peterborough                         Wolverhampton                                         Peterborough
                                                                                                                                                                                                                                                                                              Six Sigma Consultancies

    to meet all donor sperm requirements.                                                                                     Birmingham
                                                                                                                                       Coventry                Kettering
                                                                                                                                                                                                                                  Coventry                Kettering
                                                                                                                                                                                                                                                                                             Manufacturers - Drugs / Vaccines /
                                                                                                                                                                                                                                                                                              Cements / Contrast Agents –                   Supply Chain Strength
                                                                                                                                                                                                                                                                                              Pharma - Biotech                              Through the diversity of Life Sciences
                                                    Academic Centres                                                                                   Northampton                                                                                Northampton

    Clinical Trials Strength                           Medical Schools                                    Hereford
                                                                                                                      Worcester Stratford-upon-Avon

                                                                                                                                                           Milton Keynes

                                                                                                                                                                                                                 Worcester Stratford-upon-Avon

                                                                                                                                                                                                                                                      Milton Keynes
                                                                                                                                                                                                                                                                                Cambridge    Material & Component Distributors             businesses from MedTech, Diagnostics,
                                                                                                                                                                                                                                                                                                                                              iotech and Pharmaceutical there has
                                                       University
    The Midlands strength lies in the spectrum         University Clinical Trials Centre                                                                             Luton                                                                                      Luton
                                                                                                                                                                                                                                                                                                                                            developed an equally diverse and
    of research undertaken in the region and           University Life Sciences                                                                                                                                                                                                                                                            adaptable supply chain, this is further
    the opportunities that exist for
                                                        Research Centre                                Academic Centres                           Oxford
                                                                                                                                                                                                   Manufacturing Services                    Oxford
                                                                                                                                                                                                                                                                                                                                            enhanced by the academic research bases
                                                                                                                                                                                                                                                                                                                                            not only within the Life Sciences sector
    collaborations. The region’s unique                                                                                                                                        London                                                                                     London
                                                                                                                                                                                                                                                                                                                                            per se but within the Engineering,
    infrastructure offers an integrated                                                                                                                                                                                                                                                                                                     Sciences, Computing and usiness
    research and innovation platform that                                                                                                                                                                                                                                                                                                   Schools. The broad diversity of companies
    spans discovery, development, validation,                                                                                            Leeds                                                                                      Leeds
                                                                                                                                                                                                                                                                                                                                            in the region are also a magnet to attract
    clinical implementation and ultimately                                                                                                                                                                                                                                                                                                  and retain high paid, qualified staff
                                                    NHS Trust & Hospital Locations                                                                                                                                                                                                          Transport, Packaging & Logistics                through broader career opportunities with
    evaluation, making the Midlands the go-to                                                                                                                              Grimsby                                                                                    Grimsby
                                                     Acute Hospital
                                                                                                                      Manchester                                                                                  Manchester                                                                 Automation Packaging /                        concomitant benefit to the regional
    location for accelerated execution and                                                               Liverpool                                                                                   Liverpool
                                                                                                                                                                                                                                                                                                                                            economy. This diversity of companies also
                                                     Acute Hospital & Trust Main HQ                                                      Sheffield                                                                                  Sheffield                                                Dispensing and Assembly Equipment -
    adoption of clinical trials. The Midlands has    Acute Hospital /                                                                                                                                                                                                                        Design & Build - Sales                        provides sustainability in the sector as it is
                                                                                                                                                                   Lincoln                                                                                    Lincoln
                                                      Specialist Treatment Centre
    one of the largest and most stable and           Ambulance Service & Trust Main HQ
                                                                                                                                                                                                                                                                                             Logistics & Warehousing Services              not dependent on one principal company
    diverse populations in the UK with a             Children’s Hospital
                                                                                                                                                                                                                                                                                             Medical / Clinical Packaging Services         and prevents susceptibility to any impacts
                                                                                                                           Stoke on Trent                                        Boston                               Stoke on Trent                                        Boston
                                                     Children’s Hospital & Trust Main HQ                                                      Nottingham                                                                                 Nottingham                                          & Supplies                                    on the regional economy by a loss of any
    demographic mix that gives the region an                                                         Oswestry
                                                                                                                                         Derby                                                                                      Derby
                                                                                                                                                                                                                                                                                             Rail Freight
                                                     Community Health Trust Main HQ
                                                                                                                                                                                                                                                                                                                                            ma or player. The region is particularly
    unrivalled patient catchment area making         Community Hospital /
                                                                                                         Shrewsbury                                                                                  Shrewsbury
                                                                                                                                                                                                                                                                                             Main Airports
                                                                                                                                                                                                                                                                                                                                            well placed to take advantage of the trend
                                                      Specialist Treatment Centre                                                                                                                                                                                                            Smaller Airports
    it an unparalleled clinical research base for    Community Hospital / Specialist                           Wolverhampton
                                                                                                                                                                       Peterborough                         Wolverhampton
                                                                                                                                                                                                                                                                  Peterborough                                                              towards outsourcing which is reflected in
    Life Sciences businesses. Thus the large          Treatment Centre & Trust Main HQ                                        Birmingham                                                                                 Birmingham                                                                                                         the Midlands Engine’s strengths in its
                                                     Dental Hospital                                                                  Coventry                Kettering                                                          Coventry                Kettering
    stable population (multiple generations          Mental Health - Hospital /
                                                                                                                                                                                                                                                                                                                                            service and supply chain across the
    of key ethnic groups) provides an ideal           Treatment Centre                                               Worcester Stratford-upon-Avon
                                                                                                                                                                                     Cambridge                   Worcester Stratford-upon-Avon
                                                                                                                                                                                                                                                                                                                                            pharmaceutical, biotech and medical
                                                     Mental Health & Trust HQ                                                                                                                                                                                                                                                              technology sectors. The long medical
     living laboratory’ for supporting               Ophthalmic Hospital                                  Hereford                                        Milton Keynes                               Hereford                                       Milton Keynes
                                                                                                                                                                                                                                                                                                                                            technology heritage of the region also
                                                     Orthopaedic Specialist Hospital
    translational medicine and, more widely,                                                                                                                          Luton                                                                                      Luton                                                                      makes us well prepared
                                                     Orthopaedic Hospital & Trust Main HQ       3
    the balance of market push and pull that         Trust Research Centre                                                                                                                                                                                                                                                                 for the challenges of escalating regulatory
                                                     Women’s Hospital & Trust Main HQ                NHS Trust & Hospital Locations              Oxford
                                                                                                                                                                                                   Transport, Packaging & Logistics          Oxford

                                                                                                                                                                                                                                                                                                                                            requirements within the medical sector.
    keeps life sciences innovation relevant
    and applicable.                                                                                                                                                                                                                                                       London
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