Functional ingredients for dietary supplement industry - SUDATHIP SAE-TAN, Ph.D. Department of Food Science and Technology Faculty of ...
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Functional ingredients for
dietary supplement industry
SUDATHIP SAE-TAN, Ph.D.
Department of Food Science and Technology
Faculty of Agro-Industry
Kasetsart University
March, 2021
1
Health Concerns
22
Nutraceuticals
Nutrition
+
Pharmaceutical
"A nutraceutical is a food or part of a food such
as a dietary supplement that has a medical or
health benefit including the prevention and
treatment of disease".
3
2022
2015
$170 Billion
$302 Billion
Allied Market Research, 2020
100%
90%
80%
70%
60% Row
50% North & South America
40% Europe
30% Asia
20%
10%
0%
2007 2015 2020 Frost & Sullivan, 2016
4
CONSUMER TRENDS IN SUPPLEMENTS
Mental health &
Healthy aging Gut health and wellness
well-being
55
Immune health Sports & Beauty
Performance
CONSUMER TRENDS IN SUPPLEMENTS
Mental health &
Healthy aging Gut health and wellness
well-being
66
Ingredients to watch for healthy ageing
Antioxidant
Claim for a wide range of healthy
ageing benefits
1 ASTAXANTHIN
2 MAQUI BERRIES
3 GRAPE SEED EXTRACT
7
Ingredients to watch for healthy ageing
Astaxanthin
Claim: High in antioxidants
Source for industry: algae Haematococcus pluvialis (H. pluvialis)
(bacteria, microalgae, yeasts)
H. pluvialis is a green microalga that grows in fresh and brackish (slightly salty) waters.
Under certain 'stressful' conditions, such as high light intensity or nutrient shortage,
the cells of H. pluvialis accumulate astaxanthin, which turns them a dark-red colour.
Synthetic or 'manufactured' forms of astaxanthin are also available (EFSA).
8
Astaxanthin
9
Astaxanthin
Skin-protection
Anti-inflammation
Immune- enhancing effects
10
Nutrients, 2018Maqui berries
• Antioxidant
• Cardiovascular disorder
• Obesity
• Analgesic activity
11
Agronomy. 2019Maqui berries
• Anti-diabetes
• Anti-inflammation
Eye health
• Dry eye disease
Suppress light-induced
photoreceptor
cell death by inhibiting
ROS production 12
Phytochemistry Reviews. 2017Maqui berries
13Maqui berries
14Ingredients to watch for healthy aging
Grape seed extract
Bioactive compounds
Monomeric &
Oligomeric flavan-3-ols
15Grape seed extract
Antioxidant • Cardiovascular disorder
Anti-ulcer activity
Anti-cancer
16
Nutr J. 2017Grape seed extract
Chemoprevention of cellular
damage
17
Current Pharmarceutical Biotechnolgoy, 2001.Grape seed extract
18Grape seed extract
#1 Beauty and Personal Care
- Facial treatment, shampoo,
conditioner, hand cream,
sunscreen, moisturizer, serum
19Grape seed extract
Food and drink (9%)
- Meal replacement drinks, Pre-workout drinks, Drinks, Gummy
Coconut Water + Chocolate Kola Nut Flavoured
Post Workout Cardio Plant Vegan Pre-Workout Pomegranate New Zealand Super
Based Powder Powder Tea
blend of white tea, grape seed
extract and natural pomegranate
flavour 20CONSUMER TRENDS IN SUPPLEMENTS
Mental health &
Healthy aging Gut health and wellness
well-being
21
21Products that support mental health and well-being
A rise of mental health awareness and well-being
- Consumers seek for holistic solutions.
- Long-term physical, mental and emotional health
- Stress becomes a key health concern.
- Greater awareness for environmental impacts
22
22Products that support mental health and well-being
Beauty and Personal care products
Improve or Internal &
change external well-
appearance being
23
23Products that support mental health and well-being
24
24Mental health and well-being
Links between mental states and
performance
Solutions that support people with
focus, attention and even mood
elevation
1 ADAPTOGENS
2 NOOTROPICS
25
25Ingredients to watch for mental health and well-being
Adaptogens
Any ingredient that can help the body to better cope with
physical or mental stress
Originally defined as “non-specific resistance under stress”
control over their stress 26
26Adaptogens
27
27Adaptogens
Ashwagandha Holy basil Medicinal mushrooms
Cope with stress Help to relax
Nervines
28
28
Chamomile Lemon balm Valerian LavenderAdaptogens
Medicinal mushrooms
• Ganoderma lucidum (Reishi)
• Lentinus edodes (Shiitake)
• Inonotus obliquus (Chaga)
• Cordyceps sinensis (Cordyceps)
29
29Adaptogens
Ganoderma lucidum (Reishi)
1. Polysaccharides
2. Triterpenes
30
30Adaptogens
Ganoderma lucidum (Reishi):
Polysaccharides
1. Neurological effects
- Anti-depressant like effect
- Reduce anxiety-type behaviour
2. Immune-modulation
31
31
Phytochemistry. 2015Adaptogens
Ganoderma lucidum (Reishi):
Triterpenes
1. Antioxidant
- Increase antioxidant enzymes activity (SOD and catalase)
(remove ROS)
- Reduce radiation-induced oxidative DNA damage
2. Anti-cancer and cytotoxic activities
3. Anti-metastatic activities
4. Anti-HIV activity
5. Lowering urinary tract symptoms in men
6. Neuro-protective effect
32
32
Phytochemistry. 2015Adaptogens
Lentinus edodes (Shiitake)
• Amino acids
• Neutral sugar
• Total phenolics
• Organic acids
• β-glucan
• Tasty compounds
33
33
Journal of food measurement and characterization. 2012Adaptogens
Lentinus edodes (Shiitake)
1. Lower blood pressure & plasma lipids
2. Anti-gestational diabetes
3. Immune booster
J. Nutr. Sci. Vitaminol. 1987
International Journal of Medicinal Mushroom, 2017
34
34
Ann Transl Med. 2014, J Immunol Res., 2019Adaptogens
Immune Booster
Lentinus edodes Grifola frondosa
(Shiitake) (Maitake)
35
35
J Am Coll Nutr., 2015Adaptogens
Inonotus obliquus (Chaga)
Bioactive compounds:
- Hispidin analog
- Melanins
36
36
Mycosystema. 2008Adaptogens
Inonotus obliquus (Chaga)
1. Immune stimulator
2. Anti-inflammation
3. Hypoglycemic and antioxidant activity
4. Anti-tumor activity
Mycosystema. 2008
Journal of Ethnopharmacology. 2009
Journal of Food Biochemistry, 2010
37
37
International Journal of Medicinal Mushrooms, 2011Adaptogens
Cordyceps sinensis (CS)
Active ingredients
• Polysaccharides
• Nucleotides
• Sterols
• Proteins
38
38
Journal of functional foods, 2013Adaptogens
Cordyceps sinensis (CS)
1. Adaptogenic activity
2. Immunomodulatory effects
3. Antioxidant activity
4. Anti-cancer
5. Anti-diabetes activity
6. Anti-inflammatory activity
7. Kidney protection (Lower increment of blood uria nitrogen,
sodium secretion)
8. Lung and liver protection (Enhance oxygen utilization,
Enhance cellular oxygen uptake)
9. Apoptosis
10. Anti-fatigue and improve stamina
39
39
Journal of functional foods, 2013Adaptogens
Over the last five years, 35% of food, drink, or healthcare launches with
adaptogen or adaptogenic in the product description.
Rise of medicinal Nervines: Hemp extract and Tulsi Breakfast Tea
mushroom for stress lavender,chamomile, ginseng : (India) uses holy basil to
and fatigue lemon balm etc. : Hemp extracts and relieve stress
Spices and adaptogens adaptogens
40Adaptogens
“Beauty-sleep” combo Probiotic drink for stress & sleep Drinking your way to sleep &
Jelly Carrageenan and Konjac with Contains kefir culture, probiotics, relax
Chamomile, Lemon Balm, Lavender, lemon and lavender that are said contains hops and lemon balm
L-Theanine and 10% White Grape to relieve stress, improve mood, to help relieve feelings of
Juice helps relieve hunger and is promote restful sleep, reduce stress and to encourage
concentrated with chamomile, inflammation and lower skin peaceful sleep (Philippines).
lemon balm and l-theanine for irritation (Malaysia).
sleep (Thailand).
41Ingredients to watch for mental health and well-being
Nootropics ‘Brain boosters' or ‘Smart drugs’
42Nootropics
Caffeine is considered the most common nootropic.
Other emerging nootropics are B vitamins, choline,
L-theanine, MCT oils, omega-3s and ginko biloba
THAILAND
30%
of Thai consumers use functional foods and
drink to support and maintain healthy brain
function
43Nootropics
Mintel's Augmented Human Trend,
Discusses how recent innovations are enhancing the
way we live – offering opportunities to push the
body beyond its limits.
44Nootropics
Contains a unique herbal blend Contains L-theanine The caffeinated beverage is
of amla, gotu kola, ginkgo Suntheanine, NZ Neuroberry made with natural functional
biloba, siberian ginseng, green Juice and NZ Pine Bark Extract ingredients like gingko biloba,
tea and B vitamins and zinc to Enzogenol for mental focus turmeric, siberian ginseng,
boost focus (Australia). and clarity (New Zealand). green tea, caffeine, vitamin B6
and vitamin B12 for mind and
health benefits (Australia).
45Nootropics
Contains a comprehensive Contains caffeine (95mg), B Contains L-tyrosine, vitamins C,
formula blend of dark vitamins, choline, green tea E, B12 and B6 and electrolytes
chocolates and natural and ground ginger that help to such as sodium, magnesium
nootropics including lion's deliver alertness and focus and potassium for focus,
mane mushroom, green tea without the drawbacks of the hydration and recovery (US).
extract, ginkgo biloba, sugar commonly found in
natural caffeine and B energy drinks (US).
vitamins to increase mental
energy.
46CONSUMER TRENDS IN SUPPLEMENTS
Mental health &
Healthy aging Gut health and wellness
well-being
47
47Ingredients to watch for gut health and wellness
Virtual organ of the body
Human genome Microbiome
23,000 genes 3 million genes
48
BMJ, 2018Ingredients to watch for gut health and wellness
What does gut microbiome do?
Non-digestive substrate
SCFAs Gases
(acetate, propionate, butyrate)
49
BMJ, 2018Ingredients to watch for gut health and wellness
1 PREBIOTICS
2 PROBIOTICS
3 SYNBIOTICS
50Ingredients to watch for gut health and wellness
Prebiotics
Fermentable
Fiber fiber
Microbiota-accessible carbohydrates
(MACs)
51
BMJ, 2018Ingredients to watch for gut health and wellness
Prebiotics
1. Fructans
Inulin, FOS
2. Galacto-oligosaccharides
3. Starch & glucose-derived oligosaccharides
4. Other oligosaccharides
Pectin (Pectic oligosaccharide)
5. Non-carbohydrate oligosaccharides
cocoa-derived flavonols
6. Resistance starch
52
Foods, 2019Ingredients to watch for gut health and wellness
Global: top 10 fibres used in new high/added fibre food and drink
products, June 2016 and May 2020
Jun 2016 - May 2017 Jun 2017 - May 2018
Jun 2018 - May 2019 Jun 2019 - May 2020
8%
6%
% launches
4%
2%
0%
53Ingredients to watch for gut health and wellness
Prebiotics
High-fibre, FODMAP cereal Essential fibre FODMAP Guar gum promotes digestive
Food for Health breakfast clusters crispbreads balance
are FODMAP-certified and are Orgran Essential Fibre Purasana Sport Smoothie powder
generally well tolerated by IBS Crispibread. This certified provides all the nutrients needed
sufferers. Packed with the FODMAP-friendly product is a for a sporty lifestyle. It contains the
goodness of chia seeds, linseeds good source of fibre. With brown FODMAP-approved fibre Sunfiber,
and psyllium, fibres which are rice flour, sorghum flour and made from partially hydrolysed
well tolerated by people with IBS psyllium seed husk to support guar gum to promotes healthy
(Australia). healthy digestion (South Africa). digestive balance (Belgium). 54Ingredients to watch for gut health and wellness
Prebiotics
Poorly absorbed SCFAs, sugar polyols
55
The British Journal of Nutrition, 2016Ingredients to watch for gut health and wellness
Probiotics
A live microbial feed supplement, which beneficially affects the host by
improving its intestinal microbial balance
- Immune modulation
- Anti-cancer, Anti-tumor
- Reduction of cholesterol
- Alleviation of lactose intolerance
- Normalization of stool transit
- Hepatic encephalopathy
- Treatment of peptic ulcers
56
Beneficial Microbes, 2010Ingredients to watch for gut health and wellness
Prebiotics vs Probiotics
Prebiotics are gaining traction in Asia Pacific and following the footsteps of
57
probiotics in food, drink and healthcare launches globally.Ingredients to watch for gut health and wellness
Synbiotics
Synergistic mixture of probiotics and prebiotics that
benefit the host by improving the survival and
colonization of live beneficial microorganisms.
Known synbiotic formulations are Bifidobacteria with
fructooligosaccharides (FOS) and Lactobacillus
rhamnosus GG with inulin.
58
Int J Mol Sci. 2019Ingredients to watch for gut health and wellness
Synbiotics
59Ingredients to watch for gut health and wellness
Postbiotics
A new term for “metabolic by-products” or "beneficial waste
products" of probiotic bacteria
60
Current opinion in food science. 2020Ingredients to watch for gut health and wellness
Postbiotics
• Organic acids or SCFAs
• Peptidoglycans
• Polysaccharides.
• Peptides
• Teichoic acis
• Cell surface protein vitamins
• Plasmalogens
61
Current opinion in food science. 2020Ingredients to watch for gut health and wellness
Postbiotics
Postbiotics derived from Bifidobacterium breve C50
- Trigger the host immune system
- Trigger anti-inflammatory responses
62
Current opinion in food science. 2020Ingredients to watch for gut health and wellness
Psychobiotics
Psychobiotics, probiotics that affect the brain, may
have potential to help people struggling with
anxiety and depression.
63
PsychopharmacologyIngredients to watch for gut health and wellness
Psychobiotics
- Anxiety
- Depression
- Nociceptive
- Stress
- Feeding
- Taste preference
64
J Clin Invest, 2015Mungbean @ KU
Anti-inflammation
- RAW246.7 cells
- Acute liver injury mice
- 3T3-L1
Anti-diabetes
- Inhibit α-amylase
- Inhibit α-glucosidase
- Inhibit AGEs formation
- Increase insulin signaling
65Mungbean
LPS
TLR CD14
P
TAK1
COX2
IKKα iNOS
IKKβ
Cytoplasm
P
IκB Nucleus
NF-κB
NF-κB
NF-κB binding site 66Mungbean @ KU
Anti-diabetes
- Inhibit α-amylase
- Inhibit α-glucosidase
- Inhibit AGEs formation
- Increase insulin signaling
67Mungbean @ KU
2020 2021 2022
- Extraction - Drying - Subchronic toxicity
improve bioavailability
pilot scale Novel
- Efficacy in animal models Food
- Acute toxicity
2023 – Clinical studies
Health
Claim 68Interested focuses
Well-being
- Healthy aging
- Mental health
- Gut health
69
69Interested focuses
Europe:
Organic & Natural
APAC:
Natural & Blend of traditional
North America:
Natural
70
70THANK YOU
Sudathip Sae-tan, Ph.D.
Phone: +662 562 5037
Email: fagists@ku.ac.th
sudathip.sa@ku.th
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