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   City Health Information                                                         Volume 41 (2022) | No 2; 9-16

           New York City Department of Health and Mental Hygiene

     PREVENTING, DIAGNOSING, AND MANAGING TICKBORNE DISEASES
  • Hundreds of New Yorkers are diagnosed with a tickborne disease (TBD) each year. Reports of TBDs have
    been increasing in New York City (NYC) as the geographic range and seasonality of several tick species
    expands.
  • Most New Yorkers diagnosed with a TBD reported travel to an endemic area, including upstate New York,
    Long Island, and surrounding states.
  • Tick surveillance continues to identify blacklegged ticks in Staten Island and the Bronx, along with the
    emergence of Gulf Coast ticks in Staten Island, that have tested positive for several TBD pathogens.
  • Locally acquired cases of Lyme disease and babesiosis continue to be reported in Staten Island and the
    Bronx.
  • Be aware of endemic and emerging ticks and TBDs in and around NYC, how to test for TBDs or request
    assistance for specialized testing, and where to find guidance on treatment.

   Nearly 500,000 people are diagnosed and                  spotted fever (RMSF), or Powassan virus disease
treated for tickborne diseases (TBDs) each year             are reported in NYC.2
in the United States (US). In New York City (NYC),             Most cases of TBDs are associated with travel
reports of TBDs have been increasing as the                 outside of NYC, commonly to upstate New York,
geographic range of several tick species has ex-            Long Island, Connecticut, Massachusetts, New
panded.1-3 The TBD that is most reported in NYC             Jersey, and Pennsylvania.2 Not all areas of NYC
is Lyme disease, followed by anaplasmosis and               are suitable for all ticks because of their complex
babesiosis.2 Very few cases of ehrlichiosis, spot-          life cycle that requires an appropriate habitat
ted fever rickettsioses, including Rocky Mountain           and host animals. However, tick surveillance
                                                            shows the blacklegged tick and lone star tick are
INSIDE THIS ISSUE (click to access)                         established in Staten Island and the northern
 INTRODUCTION                                               Bronx, where cases of Lyme disease and babesi-
   Tickborne diseases in New York City (box)                osis without associated travel have been report-
 TICKS OF CONCERN
                                                            ed for several years (Box 12,4). Tick surveillance
                                                            has also detected 2 new tick species in NYC. Gulf
 EDUCATE PATIENTS ABOUT TICKBORNE DISEASES
                                                            Coast ticks were first identified in Staten Island in
   What to tell patients about tick bite prevention (box)
   Insect repellent (box)
   How to remove a tick (box)
 TICKBORNE DISEASE VACCINES
 DIAGNOSING TICKBORNE DISEASES
   Testing for tickborne diseases (box)
 LYME DISEASE PROPHYLAXIS
                                                             BLACKLEGGED TICK     LONE STAR TICK   AMERICAN DOG TICK
 TREATING TICKBORNE DISEASES
 REPORTING
 SUMMARY
 RESOURCES FOR PROVIDERS
 RESOURCES FOR PATIENTS
 REFERENCES
 CONTINUING MEDICAL EDUCATION ACTIVITY (1 CREDIT)                     GULF COAST TICK         ASIAN
                                                                                         LONGHORNED TICK
PREVENTING, DIAGNOSING, AND MANAGING TICKBORNE DISEASES - City Health Information
City Health Information                                                                                                                  Volume 41 (2022)

2018,4 and Asian longhorned ticks have become                                        Powassan virus disease, and Borrelia miyamotoi,
well established in Staten Island and are displac-                                   the bacteria that causes Borrelia miyamotoi
ing populations of blacklegged ticks.2                                               disease (sometimes called hard tick relapsing
  The geographic expansion of several tick                                           fever).5
species and the increase in TBDs over the past                                          In NYC, the blacklegged tick is established in
several decades are associated with increases in                                     Staten Island and areas of the Bronx, including
suburban development and deforestation in the                                        Pelham Bay Park and Hunter Island.2 Testing of
northeastern US.1 The changing landscape puts                                        these ticks has consistently detected B burgdorferi
people in close contact with host species, such as                                   in up to 50% of those sampled (unpublished
small rodents and deer, that enable the spread                                       data, NYC Vector Surveillance). The pathogens
and growth of tick populations.1 Furthermore,                                        A phagocytophilum, B microti, and B miyamotoi
changing climate patterns can alter the natural                                      have each been detected in less than 7% of ticks
environment and long-standing ecological re-                                         sampled in recent years (unpublished data,
lationships, causing changes in seasonality and                                      NYC Vector Surveillance). Since 2017, only 8
location of TBDs.1                                                                   ticks, and of those, only one tick in 2021, have
                                                                                     been collected from the Bronx and have tested
TICKS OF CONCERN                                                                     positive for Powassan virus (unpublished data,
  The main ticks of concern in the northeastern                                      NYC Vector Surveillance).2 The blacklegged tick
US are the blacklegged tick (Ixodes scapularis),                                     is found in most New York counties outside of
lone star tick (Amblyomma americanum), and                                           NYC.6,7
American dog tick (Dermacentor variabilis).5
                                                                                        Cases of anaplasmosis have been increasing,
Other ticks of concern have expanded their
                                                                                     most notably among Manhattan and Brooklyn
range to the northeast, such as the Gulf Coast tick
                                                                                     residents.2 Cases of Lyme disease and babesiosis
(Amblyomma maculatum), which has migrated
                                                                                     have plateaued recently, but local transmission
northward from the south and mid-Atlantic US
                                                                                     is ongoing in Staten Island and in focal areas of
and is now established in Staten Island.2,5
                                                                                     the Bronx.2 Powassan virus disease is rare, and
  The blacklegged tick is a vector for several                                       no locally acquired cases have been reported in
TBD pathogens, including the bacteria that can                                       NYC.2 B miyamotoi, a spiral-shaped bacterium
cause Lyme disease (Borrelia burgdorferi) and                                        distantly related to B burgdorferi, has also been
anaplasmosis (Anaplasma phagocytophilum), the                                        found in blacklegged ticks in the northeastern
intraerythrocytic parasite that causes babesiosis                                    US.8 At this time, infection with B miyamotoi is
(Babesia microti), the Powassan virus that causes                                    thought to be an uncommon cause of illness,

 BOX 1. TICKBORNE DISEASES IN NEW YORK CITYa-c,2,4
  • Lyme disease continues to be the most reported tickborne disease (TBD), though cases leveled off from 2018 to 2020, with
    an average of 764 cases per year and a slight increase to 820 cases in 2021. Similarly, cases of babesiosis also leveled off
    from 2018 to 2020, with an average of 84 cases per year, and a slight increase to 102 cases in 2021
  • Cases of anaplasmosis increased from 65 in 2018 to 125 in 2021, a 92% increase
  • TBDs reported with less frequency include ehrlichiosis (average, 13 cases/y, 2018-2021), spotted fever group rickettsioses,
    including Rocky Mountain spotted fever (average, 2 cases/y, 2018-2021), and, rarely, tularemia and Powassan virus disease
  • Blacklegged and lone star ticks are established in Staten Island and the Bronx, and Gulf Coast ticks are established only in
    Staten Island. Testing of these ticks has detected several TBD pathogens
  • Most cases of TBDs are among residents of Manhattan and Brooklyn who were infected while traveling to endemic areas
    surrounding New York City
  • Local transmission of TBDs occurs primarily in Staten Island, where
        ○ 50% of people with Lyme disease did not travel in 2021, similar to previous years
        ○ Locally acquired babesiosis cases continue to occur in similar numbers with fluctuations year to year; 5 cases were
          reported in 2021

 a
     TBDs include anaplasmosis, babesiosis, ehrlichiosis, Lyme disease, and Rocky Mountain spotted fever
 b
  For residents of outer boroughs diagnosed with erythema migrans (EM) from April 1 to October 31, travel history during the 3- to 30-day incubation period was
 obtained from either provider or patient. Manhattan residents were excluded as there is no evidence of local transmission of Lyme disease in the borough; a
 previous study showed 97% of people with EM reported travel, and Manhattan has fewer potential blacklegged tick habitats
 c
     Unpublished data, 2021, New York City Tickborne Disease Surveillance

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though it is not a reportable condition, so            and on the correct removal of an embedded tick
national case counts are unknown.8                     (Box 412). Ticks are most active in NYC during
   The lone star tick transmits the bacteria that      the spring, summer, and fall.12 Advise patients
can cause ehrlichiosis (Ehrlichia chaffeensis, E       to take precautions against ticks during these
ewingii), Heartland virus (a virus that can cause      months and be aware of signs and symptoms of
Heartland virus disease), and Bourbon virus (a         TBDs. Most infections result from an undetected
virus that can cause Bourbon virus disease).5 In       tick bite; early detection and prompt removal
NYC, this tick is prevalent in Staten Island and the
northern Bronx.2 Ehrlichiosis cases in NYC are          BOX 2. WHAT TO TELL PATIENTS ABOUT TICK
predominantly travel-associated (unpublished                   BITE PREVENTION9,12,13
data, NYC TBD Surveillance). Heartland and               • Avoid wooded areas and overgrown grasses
Bourbon viruses have been detected in ticks              • Use insect repellent as directed (Box 3)
in New York State but not among ticks in or              • Wear light-colored clothing and long-sleeved shirts
residents of NYC.2 The bite of a lone star tick is         tucked into pants and long pants tucked into socks
associated in some people with the development           • Check yourself, children, and pets for ticks when
                                                           returning indoors from tick-endemic areas
of alpha-gal syndrome, an allergy to mammalian
meat and meat products.9 The lone star tick              • Remove any ticks immediately (Box 4)
bite has also been associated with southern tick         • Shower within 2 hours of returning indoors
associated rash illness (STARI).10 Although STARI       See Resources for Patients for more information
is not a reportable disease in NYC, case counts are
believed to be low.
                                                        BOX 3. INSECT REPELLENT9,14-16
  The American dog tick is found in all NYC
                                                        Generally, the higher the percentage of the active
boroughs, though numbers have been decreasing
                                                        ingredient, the longer the duration of protection.
over time.2 It transmits the bacterium Rickettsia       Use a repellent that has one of the following active
rickettsii, which causes RMSF, and the bacterium        ingredients:
Francisella tularensis, which causes tularemia.5         • DEETa
  The Gulf Coast tick (A maculatum) has been             • Picaridin
identified in some parks in Staten Island as             • IR3535
of 2018.4 Tick testing detected the presence of         Use a repellent that is registered with the
Rickettsia parkeri, which causes a spotted fever        Environmental Protection Agencyb
syndrome similar to that caused by R rickettsii          • Carefully read labels to find a product that repels ticks,
and Rickettsia akari, and often results in an              not just mosquitoes
eschar at the bite site.2,4,5                            • Follow directions on the repellent’s label
                                                         • Do not spray products directly onto the face and avoid
   The Asian longhorned tick (Haemaphysalis                the eyes and mouth
longicornis) was reported in the US for the first
                                                         • Determine from the label how long protection should
time in 2017.9 Populations of this tick have been          last; reapply when spending a longer time outdoors in
expanding in parks in Staten Island and in the             tick habitats
Bronx, and have begun to displace established            • Apply permethrin to clothing, shoes, and gear, but not
populations of blacklegged ticks in Staten                 to skin
Island.2 This tick is thought to feed mostly on         Use a repellent that is safe for children
livestock and animals.9 It does not prefer to bite       • Apply the product to your hands and then put it on
humans and has not been shown to transmit                  the child, avoiding the eyes, mouth, and hands; apply
human pathogens in the US.9 In parts of Asia,              sparingly on the ears
however, it is a vector for severe fever with            • DEET-based repellents are approved for use on children
thrombocytopenia syndrome virus.11                             ○ For children aged older than 2 months, use a
                                                                 repellent with up to 30% DEET
EDUCATE PATIENTS ABOUT TICKBORNE                               ○ Do not apply more than once a day
DISEASES                                                       ○ Wash or bathe skin and clothing with soap and
                                                                 water when returning indoors
   Inform patients that living in or traveling to
tick endemic areas puts them at risk for acquiring      a
                                                            Repellents with more than 50% DEET do not offer longer protection
TBDs. Educate patients who visit, live, work,           b
                                                            Products with active ingredients not registered by the Environmental
or travel in endemic areas on the prevention                Protection Agency have not been evaluated for effectiveness
of tick bites and TBDs (Boxes 29,12,13 and 39,14-16)
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reduce the chance of disease.13 Erythema migrans      thrombocytopenia, anemia, and elevated liver
(EM)—a red ring-like or expanding rash—is             function tests.5 A rash is sometimes seen with
diagnostic for Lyme disease, but care should be       ehrlichiosis, particularly among children, but is
taken to distinguish EM from other causes of skin     rare with anaplasmosis (5 cm is sufficient for          ○ Use petroleum jelly (Vaseline®), nail polish
a diagnosis of Lyme disease without other signs              remover, or heat to remove the tick. These
or symptoms, though care should be taken to                  methods can increase the risk of infection
distinguish EM from other causes of skin rash.13        • Dispose of a crawling tick or an embedded tick that
Acute Lyme disease can also manifest as cranial           has been removed by wrapping it tightly in tape and
                                                          throwing it out or flushing it down the toilet. To save a
neuritis (most often facial palsy), oligoarthritis,
                                                          tick for identification, put it in a container with alcohol
and/or carditis (most often atrioventricular              or in a sealed bag/container
block).5                                                • Advise patients to contact a health care provider
Rickettsial diseases                                      immediately if they develop fever, aches and pains, or
                                                          a rash
  Laboratory findings for anaplasmosis,
ehrlichiosis, and spotted fever group rickettsioses    See Resources for Patients for more information on
                                                       tick identification and removal, including a video
(SFGRs), including RMSF, may include                   demonstrating correct removal

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PREVENTING, DIAGNOSING, AND MANAGING TICKBORNE DISEASES - City Health Information
City Health Information                                                                                            Volume 41 (2022)

diagnosed with these diseases recall being bitten                    LYME DISEASE PROPHYLAXIS
by a tick.2 Recent travel during warmer months
                                                                       Antibiotic prophylaxis may be used for Lyme
to upstate New York, Long Island, and other
                                                                     disease but not for other TBDs.22 New guidelines
parts of the Northeast, mid-Atlantic, and upper
                                                                     from the Infectious Diseases Society of America
Midwest should prompt consideration of TBDs.2,5,9
                                                                     (IDSA) indicate that doxycycline is acceptable
   While relatively rare, coinfection with more                      for prophylaxis in adults and children.22 A single
than one TBD pathogen can occur from a single                        dose of doxycycline (200 mg for adults or 4.4 mg/
tick bite if the species, such as the blacklegged                    kg for children of any age weighing less than
tick, is capable of harboring more than one                          45 kg) may be offered to patients to reduce the
TBD pathogen.5 Testing for multiple TBDs when                        risk of Lyme disease when all of the following
clinically appropriate can aid in the diagnosis of                   circumstances exist13,22:
TBD coinfections.
                                                                        • the patient has spent time in a Lyme-endemic
  Testing for most TBDs is available at most                              region,
commercial labs (Box 55,9,19-21). However, testing                      • the tick has been attached for ≥36 hours,
for rare or emerging TBDs may only be available                           based on engorgement or history,
through the NYC Department of Health and                                • prophylaxis can be started within 72 hours of
Mental Hygiene. Contact the Provider Access Line                          tick removal,
at 866-692-3641 for assistance.                                         • the tick can be reliably identified as an
  For more detailed guidance on diagnostic                                Ixodes spp tick, and
testing, see Tickborne Diseases of the United                           • the patient does not have any
States.                                                                   contraindications to treatment with
                                                                          doxycycline.

 BOX 5. TESTING FOR TICKBORNE DISEASES5,9,19-21
 Optimal diagnostic tests depend on timing relative to symptom onset and disease
 Rickettsial diseases
  • Polymerase chain reaction (PCR) tests for anaplasmosis and ehrlichiosis are most sensitive during the first week of illness.
    For Rocky Mountain spotted fever (RMSF), PCR can be done on whole blood but is less sensitive, and a negative result
    cannot rule out infection
  • Serologic assays may lead to false-negative results when performed in the 1 to 2 weeks following illness onset.
    Additionally, antibodies may persist for several years and, if detected, may not be indicative of current illness. Repeat
    serologic testing on a convalescent specimen after 2 to 4 weeks with a fourfold or greater rise in antibody titers confirms a
    diagnosis
  • False-positive serologic results may occur with RMSF. Antibodies to spotted fever group rickettsioses (SFGRs) other than
    RMSF may reflect past exposures to a wide variety of SFGR species, including Rickettsia akari, and not reflect incident cases
    of RMSF. R akari is the causative agent of rickettsialpox. For rickettsialpox testing, contact the NYC Provider Access Line at
    866-692-3641 to arrange for testing at the Centers for Disease Control and Prevention (CDC)
 Lyme disease
  • The CDC recommends a 2-step test for Lyme disease. If the first antibody test is negative, no further testing is
    recommended. If positive or equivocal, perform a Western blot test or a second enzyme immunoassay (modified 2-tier
    test). The overall result is positive only when the first test is positive or equivocal and the Western blot is positive, or when
    a modified 2-tier test is positive or equivocal
 Babesiosis
  • PCR and identification of intraerythrocytic Babesia parasite by blood smear should be used to confirm a diagnosis
  • Serology: Indirect immunofluorescence antibody testing for immunoglobulin G offers evidence of infection but cannot
    distinguish between active and prior infection
 Tick testing
 Testing ticks for diseases is generally not recommended because
  • Results may be unreliable; laboratories that test ticks are not required to meet the same quality standards as clinical
    laboratories
  • A positive test does not mean that the tick was attached long enough to transmit the pathogen
  • A negative test might provide a false sense of security as a patient might have unknowingly been bitten by a different tick

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City Health Information                                                                                    Volume 41 (2022)

  Parents of children under age 12 years should                  (including 2 final weeks during which parasites
be advised to continue monitoring for signs and                  are no longer detected on peripheral blood
symptoms of Lyme disease, as the efficacy of                     smear).21.23
single-dose doxycycline prophylaxis in children is
not well studied.22
                                                                 REPORTING
                                                                   Lyme disease, babesiosis, anaplasmosis,
TREATING TICKBORNE DISEASES                                      ehrlichiosis, SFGRs, tularemia, and Powassan
   Most TBDs are treatable with antimicrobial                    virus disease are reportable in NYC. Report
agents. Confirm the diagnosis with laboratory                    confirmed TBDs within 24 hours via NYCMED.
testing, but do not delay treatment waiting for                    For more information, see Provider Reporting:
laboratory confirmation. Clinical suspicion of                   How to Report Diseases, Events, and Conditions to
anaplasmosis, ehrlichiosis, and SFGRs is sufficient              the NYC Health Department.
to begin treatment, as delays may result in severe
illness and even death. For further guidance                     SUMMARY
on testing for and treating TBDs, see Tickborne                     As tick populations in and around NYC
Diseases of the United States.                                   continue to evolve, remain vigilant for the risk
Updated guidelines for babesiosis                                TBDs pose to patients who live in or visit tick
                                                                 endemic areas. New tick species in NYC, such
  IDSA recommendations for testing and treating
                                                                 as Asian longhorned ticks and Gulf Coast ticks,
babesiosis have recently been updated.21 A
                                                                 are part of the changing landscape of ticks
single positive antibody test is not sufficient for
                                                                 and TBD prevalence. Stay up to date on local
a diagnosis of acute babesiosis and may reflect
                                                                 epidemiology and clinical practice guidelines
a Babesia infection that occurred years before
                                                                 to inform testing and treatment considerations.
or a false-positive test result.21 Confirm an acute
                                                                 Prompt treatment based on clinical presentation
babesiosis diagnosis with a peripheral blood
                                                                 is critical to preventing severe disease; do not
smear examination or PCR test.21
                                                                 delay treatment while awaiting confirmatory test
  The antibiotic combination of atovaquone                       results. Encourage patients to seek care if they
and azithromycin is the preferred treatment for                  experience symptoms compatible with TBDs after
patients experiencing babesiosis; clindamycin                    exposure to a tick habitat or following a recent
and quinine is an alternative combination.21,23                  tick bite. Educate patients on how to prevent
The duration of antimicrobial therapy for                        tick bites by avoiding grassy, wooded areas,
babesiosis is 7 to 10 days in immunocompetent                    using repellent, wearing protective clothing, and
patients. For immunocompromised patients,                        checking themselves for ticks.
therapy should be at least 6 consecutive weeks

RESOURCES FOR PROVIDERS
 General information                                             Training
 • US Department of Health and Human Services and                • Northeast Regional Center for Excellence in Vector-Borne
   Centers for Disease Control and Prevention (CDC).               Diseases: https://www.neregionalvectorcenter.com
   Tickborne Diseases of the United States: https://www.cdc.     Reporting
   gov/ticks/tickbornediseases/index.html
                                                                 • New York City Department of Health and Mental Hygiene
 • CDC. Instructions for submitting diagnostic specimens for       (NYC DOHMH). Provider Reporting: How to Report Diseases,
   testing by the rickettsial reference diagnostic laboratory:     Events, and Conditions to the NYC Health Department:
   https://www.cdc.gov/ncezid/dvbd/specimensub/rickettsial-        https://www1.nyc.gov/assets/doh/downloads/pdf/hcp/
   shipping.html                                                   reporting-guide.pdf
 Erythema migrans poster                                         • NYC DOHMH. NYCMED: https://a816-healthpsi.nyc.gov/
 • CDC. The Many Forms of Lyme Disease Rashes (Erythema            NYCMED/Account/Login
   Migrans): https://www.cdc.gov/lyme/resources/NCEZID_
   rash_poster3r1-508.pdf

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City Health Information                                                                                                                     Volume 41 (2022)

 RESOURCES FOR PATIENTS
 General information                                                               • NYC DOHMH. Insect repellent safety: https://www1.nyc.
                                                                                     gov/site/doh/health/health-topics/insect-repellent-safety.
     • New York City Department of Health and Mental Hygiene
                                                                                     page
       (NYC DOHMH). Ticks: www.nyc.gov/health/ticks
     • Centers for Disease Control and Prevention (CDC). Ticks:                    Educational materials
       https://www.cdc.gov/ticks                                                   • NYC DOHMH. Ticks Taking Over? Take Back Your Yard:
     • University of Rhode Island. TickEncounter Resource                             English: https://www1.nyc.gov/assets/doh/downloads/
       Center: https://tickencounter.org                                              pdf/zoo/tick-yard-control.pdf
 Tick identification and removal                                                      Spanish: https://www1.nyc.gov/assets/doh/downloads/
                                                                                      pdf/zoo/tick-yard-control-sp.pdf
     • NYC DOHMH. NYC Tick ID and Removal: https://www1.
       nyc.gov/assets/doh/downloads/pdf/zoo/nyc-tick-id-and-                          Call 311 to order free copies
       removal-card.pdf                                                            • NYC DOHMH. All About Ticks: A Workbook for Kids and Their
       Wallet card available in many languages; call 311 to order                    Parents:
       free copies                                                                    English: https://www1.nyc.gov/assets/doh/downloads/
     • New York State Department of Health. Tick prevention:                          pdf/zoo/tick-workbook.pdf
       removal (video): https://youtu.be/oGrK4ZKUfhQ                                  Spanish: https://www1.nyc.gov/assets/doh/downloads/
 Insect repellent                                                                     pdf/zoo/tick-workbook-sp.pdf
     • US Environmental Protection Agency. Find the repellent                         Call 311 to order free copies
       that is right for you: https://www.epa.gov/insect-                          • CDC. Tick Bite: What To Do: https://www.cdc.gov/ticks/
       repellents/find-repellent-right-you                                           pdfs/FS_TickBite.pdf

REFERENCES
1.    Centers for Disease Control and Prevention (CDC) Division of Vector-Borne    12. NYC DOHMH. Ticks. Accessed June 3, 2022. http://www.nyc.gov/health/ticks
      Diseases. Understanding Lyme and Other Tickborne Diseases. Reviewed
                                                                                   13. Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment,
      May 11, 2022. Accessed June 3, 2022. https://www.cdc.gov/ncezid/dvbd/
                                                                                       treatment, and prevention of Lyme disease, human granulocytic
      media/lyme-tickborne-diseases-increasing.html
                                                                                       anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious
2.    New York City Department of Health and Mental Hygiene (NYC DOHMH).               Diseases Society of America [correction in Clin Infect Dis. 2007;45(7):941].
      2022 Health Advisory #10: Tick-borne Disease Advisory. June 1, 2022.             Clin Infect Dis. 2006;43(9):1089-1134. doi:10.1086/508667
                                                                                                                              doi:10.1086/508667
      Accessed June 3, 2022. https://www1.nyc.gov/assets/doh/downloads/pdf/
                                                                                   14. NYC DOHMH. Insect Repellent Safety. Accessed June 3, 2022. https://www1.
      han/advisory/2022/tick-borne-diseases.pdf
                                                                                       nyc.gov/site/doh/health/health-topics/insect-repellent-safety.page
3.    Rosenberg R, Lindsey NP, Fischer M, et al. Vital signs:
                                                       signs: trends in reported
                                                                                   15. United States Environmental Protection Agency. Regulation of Skin-applied
      vectorborne disease cases—United States and territories, 2004-2016.
                                                                                       Repellents. Updated June 8, 2021. Accessed June 3, 2022. https://www.epa.
      MMWR Morb Mortal Wkly Rep.
                             Rep. 2018;67(17):496-501. Accessed June 3, 2022.
                                                                                       gov/insect-repellents/regulation-skin-applied-repellents
      https://www.cdc.gov/mmwr/volumes/67/wr/mm6717e1.htm
                                                                                   16. Balk SJ; American Academy of Pediatrics. Choosing an insect repellent for
4.    Bajwa WI, Tsynman L, Egizi AM, Tokarz R, Maestas LP, Fonseca DM. The
                                                                                       your child. July 9, 2021. Accessed June 3, 2022. https://www.healthychildren.
      Gulf Coast tick, Amblyomma maculatum (Ixodida: Ixodidae) and spotted
                                                                                       org/English/safety-prevention/at-play/Pages/Insect-Repellents.aspx
      fever group Rickettsia in the highly urbanized northeastern US. Pre-print
      December 10, 2021. Accessed June 3, 2022. https://www.biorxiv.org/           17. CDC. Tick-borne Encephalitis Vaccine. Reviewed March 28, 2022. Accessed
      content/10.1101/2021.12.08.471803v1.full                                         June 3, 2022. https://www.cdc.gov/tick-borne-encephalitis/healthcare-
                                                                                       providers/hcp-vaccine.html
5.    CDC. Tickborne Diseases of the United States.
                                            States. Reviewed January 10, 2019.
      Accessed June 3, 2022. https://www.cdc.gov/ticks/tickbornediseases/index.    18. CDC. Lyme Disease Vaccine. Reviewed December 22, 2021. Accessed June 3,
      html                                                                             2022. https://www.cdc.gov/lyme/prev/vaccine.html
6.    New York State Department of Health (NYS DOH). Deer Tick Surveillance:       19. CDC. Other Spotted Fever Group Rickettsioses: Information for Health Care
      Adults (Oct to Dec) Excluding Powassan virus: Beginning 2008. Updated            Providers. Reviewed March 29, 2021. Accessed June 3, 2022. https://www.
      March 23, 2022. Accessed June 3, 2022. https://health.data.ny.gov/Health/        cdc.gov/otherspottedfever/healthcare-providers/index.html
      Deer-Tick-Surveillance-Adults-Oct-to-Dec-excluding/vzbp-i2d4                 20. Mead P, Petersen J, Hinckley A. Updated CDC recommendation for serologic
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      Powassan Virus: Beginning 2008. Updated March 23, 2022. Accessed June            doi:10.15585/mmwr.mm6832a4
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      3, 2022. https://health.data.ny.gov/Health/Deer-Tick-Surveillance-Nymphs-    21. Krause PJ, Auwaerter PG, Bannuru RR, et al. Clinical practice
      May-to-Sept-excludin/kibp-u2ip                                                   guidelines by the Infectious Diseases Society of America (IDSA): 2020
8.    CDC. Tick-borne Relapsing Fever: B miyamotoi.
                                          miyamotoi. Reviewed September                guideline on diagnosis and management of babesiosis. Clin Infect Dis.
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      10, 2019. Accessed June 3, 2022. https://www.cdc.gov/relapsing-fever/            2021;72(2):e49-e64. doi:10.1093/cid/ciaa1216
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      miyamotoi                                                                    22. Lantos PM, Rumbaugh J, Bockenstedt LK, et al. Clinical practice guidelines
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      www.cdc.gov/ticks/index.html                                                     of Neurology (AAN), and American College of Rheumatology (ACR): 2020
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                                                 doi:10.3201/eid2405.151435

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City Health Information
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Eric Adams
Mayor

Ashwin Vasan, MD, PhD
Commissioner of Health and Mental Hygiene

Division of Disease Control
Celia Quinn, MD, MPH, Deputy Commissioner

Bureau of Communicable Disease

                                                                                                                         ASK CHI
Vasudha Reddy, Acting Assistant Commissioner
Scott Harper, MD, MPH, Medical Director, Zoonotic, Influenza, and Vector-borne Disease Unit
Sally Slavinski, DVM, MPH, Dipl ACVPM, Assistant Director, Zoonotic, Influenza, and Vector-borne Disease Unit
Asha Abdool, MPH, City Research Scientist                                                                       Have questions or comments
Jennifer Reich, MPH, CHES, City Research Scientist
                                                                                                                       about ticks?
Division of Epidemiology
R. Charon Gwynn, PhD, Deputy Commissioner                                                                                 Email
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Liz Selkowe, Medical Editor

Copyright ©2022 The New York City Department of Health and Mental Hygiene
E-mail City Health Information at askCHI@health.nyc.gov
New York City Department of Health and Mental Hygiene. Preventing, diagnosing, and managing tickborne diseases.
City Health Information. 2022;41(2):9-16.

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