Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul

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Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
Genome & Transcriptome

Propose the latest advances
in high throughput genomics

                          Visit our website
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
Skills and cutting-edge technologies
                       in genomics and transcriptomics

     A multisite core facility in Toulouse for academic & private teams working on animals,
     plants, microbes or Human

                                                                               A diversity of
                                                                             Genomic Expertise
               Technological
               advising
                                                                            Whole Genome Sequencing
                                                                               De Novo Sequencing
                                                                                 RNA Sequencing
                      Data Production                                         Single cell Sequencing
                      and analyses                                             Targeted Sequencing
                                                                                    Metagenome
                                                                                  Metabarcoding
                Watch and                                                            Microarray
                development                                                 Digital & Quantitative PCR
                                                                                    Data analysis

Medium to very high throughput of short or long reads sequencers ....................................................................
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
Key figures and publications

                                                                                                  Annual key figures
                                                                                                  • 300 teams
                                                                                                  • 480 projects
                                                                                                  • 50 publications

           Some of our recent contributions
                                                                            The genomic basis
                                                                              of color pattern
                                                                          polymorphism in the
                                                                           Harlequin Ladybird.
                                                                        Current Biology, 2018

                                                                        A specific ChREBP and
              Whole-genome analysis of
                                                                           PPARα cross-talk is
              introgressive hybridization and
                                                                      required for the glucose-
              characterization of the bovine
                                                                     mediated FGF21 response.
              legacy of Mongolian yaks.
                                                                           Cell Reports, 2017
              Nature Genetics, 2017

           And also...
           • Caloric restriction and diet-induced weight loss do not induce browning of human
              subcutaneous white adipose tissue in women and men with obesity. Cell Reports, 2018
           • One-step generation of multiple gene knock-outs in the diatom Phaeodactylum tricornutum
             by DNA-free genome editing. Nature communications, 2018
           • The sunflower genome provides insights into oil metabolism, flowering and Asterid
             evolution. Nature, 2017

................................................................................... Linked Reads and single cell analyses, ddPCR, microarrays
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
CONTACTS
               Scientific Director: Denis Milan
                      Site Managers:
                GeT-PlaGe: Cécile Donnadieu
               GeT-Biopuces: Marie-Ange Teste
                GeT-Santé: Jean-José Maoret
                  GeT-TRiX:Yannick Lippi
                        ,: get@genotoul.fr
                  :: https://get.genotoul.fr/en
For more information about our supports you can visit our website
                            : @get_genotoul

           EDUCATION & TRAINING
                            Education:
                       Master, PhD programs
                       Training:
      Workshops and theoretical and practical courses

         QUALITY CERTIFICATIONS

               GeT-PlaGe & GeT-Biopuces

    INFRASTRUCTURE & NETWORKS
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
Innovate through
a better understanding of
plants’ genome structure

            Visit our website
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
A Biological Resource Center
                 dedicated to plant genomes

                                                                  CNRGV’s collaborators

 A better understanding of plant            This Biological Resources Center (BRC)
 behavior will lay the foundation for new   is dedicated to all plant genomic
 agricultural systems. Structural genomic   resources of model and crop plants.
 exploration is fundamental to discover     The CNRGV provides innovative and
 how evolution impacts DNA                  efficient genomic tools to better
 organization and eventually plant          characterize plant biodiversity and
 diversity.                                 understand how plants evolve and adapt
 The French Plant Genomic Center            to their environment through the
 (CNRGV) is a national infrastructure       analysis of their genomes.
 unique in France belonging to the          The CNRGV is largely opened to the
 French National Institute for              international scientific community.
 Agricultural Research (INRA).

Large panel of services to decipher plant genome complexity
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
An expertise on a large diversity of plants

     Dedicated innovative solutions to study genome structure...

                               ...to understand biological processes

 BAC LIBRARY              CAPTURE OF                 OPTICAL
CONSTRUCTION             LARGE GENOME                MAPPING
                           FRAGMENT
The cloning of large
    genomic DNA              An innovative         Optical mapping to
fragments into BAC        strategy based on      obtain a physical map
 vectors to obtain a      the CRISPR-Cas9        of a genome through
reliable and accurate    technology, used in        the production of
sequence to identify      vitro to target and    fingerprints based on
   candidate genes        characterize large       large labelled DNA
                         genomic regions of             molecules
                                interest

                                 Based on various types of projects

                                  Genome                   Plant
         Plant                    analysis for             genomics
         genome                   enhanced                 serving
         sequencing               plant                    basic
                                  breeding                 research
                                                           projects
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
CONTACTS
               Scientific Director: Hélène Bergès
      Operational Managers: Arnaud Bellec, Sonia Vautrin
                   Communication: Elisa Prat
                  ,: infocnrgv-toulouse@inra.fr
                 :: https://cnrgv.toulouse.inra.fr
  For more information about our supports you can visit our website
                            : @CNRGV

                          SERVICES
           For companies and academic laboratories
                        One-off services
                     Training for autonomy
      Advice and expertise for a complete accompaniment
    Technical development or adaptation to meet your needs

      INFRASTRUCTURE & NETWORKS
CNRGV is a member of IBiSA, Genotoul and RARe networks: the
     guarantee to find an answer to all your problems
                                                                      Labelled plant DNA molecules
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
Bioinformatics

Meet the needs of large-scale
treatment in life sciences

                 Visit our website
Propose the latest advances in high throughput genomics - Genome & Transcriptome - Genotoul
A powerful hardware and software
                        infrastructure

                                         A computer farm: Thousands of cores
                                         (INTEL-2014, INTEL-2017), providing
                                         several Tera Bytes of memory, including
                                         large scale memory servers (1-3TB),
                                         Infiniband interconnection (FDR),
                                         parallel file system (GPFS).

                                         Several Peta Bytes of storage capacity.

                                         WEB servers and virtual machines
                                         hosting infrastructure.

                Open access and shared resources

Secure access (ssh) is provided to the
Life Science community.

Redundant equipments and daily
back-ups insure data protection and
security.

Hundreds of public databanks are
regularly updated.
Hundreds of bioinformatic software
are installed.

A Galaxy instance is co-maintained
with the Sigenae team (sigenae.org).
Development of software, expertize, training,
               and data analysis

New methods and tools are
developed to support data analysis
and contribute to innovative
research developments in
bioinformatics.
Recent developments include
D-GENIES, an interactive dot plot
viewer adapted to large genomes,
and mixKernel, a R package to
integrate heterogeneous data.
                                         Software development
The team also sets up and
maintains data analysis workflows.        and workflow design

                                        Genotoul Bioinfo provides
                                        support to biologists to analyse
                                        their data.
                                        Main skills are developed in
                                        genome assembly (from short
                                        and long reads), genome
                                        annotation (coding and non
                                        coding), (s)RNA-seq, methyl-seq
                                        data analyses, variant analysis,
                                        metagenomics (metabarcoding
       Expertize and data analysis      and whole genome) and data
                                        integration.

In collaboration with local actors in
the field of bioinformatics (Sigenae,
NED (GenPhySE), SaAB (MIAT),
TWB), GenoToul Bioinfo organizes
training sessions.
The catalog includes topics on
RNAseq de novo, RNAseq
mapping and quantification,
sRNAseq, variant analysis and
metagenomics.
Environments are Galaxy or                       Training
command line.
CONTACTS
        Direction team: anim.bioinfo@toulouse.inra.fr
                  :: http://bioinfo.genotoul.fr/
 For more information about our supports you can visit our website
                      : @BioinfoGenotoul

                     R&D SERVICES
           For companies and academic laboratories
          One-off services with or without assistance
                     Training for autonomy
             Advice and expertise for data analysis
   Software development or adaptation to meet your needs

            EDUCATION & TRAINING
                          Education:
                     Master, PhD programs
                        Training:
       Workshops and theoretical and practical courses

     INFRASTRUCTURE & NETWORKS
Bioinfo is a member of IBiSA, IFB and France Génomique networks,
         the guarantee to find an answer to your questions
Biostatistics

A crossroads of skills
in Statistics for Biology

                  Visit our website
Support analysis of data from
                        new bio-technologies

           Circosplot representation from the mixOmics R package. It displays
           relationships between variables among different blocks of omics data (here,
           mRNA, miRNA and proteomics).

The best term to describe the activities of the biostatistics platform is a crossroads of skills
in statistics for biology.

The activities of the platform are organized around: training, co-supervision of internships
and tutored projects, research and organization of scientific workshops.
Collaborate with us

Three representations of correlations between gene expression and clinical variables. Top
left : as an heatmap ; top right : as an heatmap considering only correlations above a
threshold ; bottom right as a relevance network.

■■   DOMAINS – We interact with
     all the domains of biology
     related to projects that generate
     huge amounts of data.
■■    METHODS – We are familiar
     with the statistical analysis of
     biological data and we have
     developed expertise in omics
     data integration.

NETWORK – The Genotoul Biostatistics platform relies on contacts disseminated
inside bio labs in Toulouse : Marion Aguirrebengoa at Center for Integrative Biology,
Jason Iacovoni at Institute of Cardiovascular and Metabolic Diseases, Sandrine
Laquerre at Laboratoire d’Ingénierie des Systèmes et des Bio-Procédés and David Rengel
at Laboratory of Plant-Microbe Interactions. It has also strong relationships with the
Bioinformatics platform.
CONTACTS
      Animators: Sébastien Déjean, Nathalie Vialaneix
              ,: biostat@math.univ-toulouse.fr
           :: http://math.univ-toulouse.fr/biostat/
For more information about our supports you can visit our website

   PARTNER IN RESEARCH PROJECTS
         For companies and academic laboratories
    Advice and expertise for a complete accompaniment
         from experimental design to data analysis
  Technical development or adaptation to meet your needs

           EDUCATION & TRAINING
                         Education:
                    Master, PhD programs
                       Training:
      Workshops and theoretical and practical courses

     CO-SUPERVISION OF STUDENTS
    Students in applied mathematics, statistics, computer
science or bioinformatics are highly welcomed to accomplish
 their internship in biostatistics co-supervised by a biologist
                and a member of the platform
Toulouse Proteomics Infrastructure

Proteomics & mass spectrometry:
high performance technologies to
explore the world of proteins

                            Visit our website
Proteomics at a glance

The Toulouse Proteomics Infrastructure is equipped with state-of-the-art
instrumentation in mass spectrometry and bioinformatics tools. It offers a wide range
of services for protein analysis from various types of samples: cell cultures, tissues,
biological fluids, plants…
Its expert staff will guide you in your research and development projects by
proposing solutions that fit your needs from a single analysis to more ambitious
projects. It is open to academia and private companies.

   Diversity of                     Expertise                       Versatility
   approaches                     Highly skilled staff             Researchers and
Several complementary            trained in the latest            engineers working
   instruments allow              innovations in the             together to develop
    a wide variety of                    field                   innovative strategies
     scientific offers

           More than just the analysis
           Consulting, advice, follow-up of results, data interpretation, and discussions
From Proteins to Function

                                                                                           is
                                                      n              tr y              alys               is
                                lin
                                   g
                                                 ratio
                                                                   me                An               alys
                               d                                  o                c                 n
                              n                pa              ctr              ati                lA
Expertise &               e Ha             n Se              pe              orm                ona
                         l               ei                 S               f                 ti
                       mp              ot                ss               in                nc
Consulting           Sa              Pr                Ma              Bio               Fu

●●   Identification and quantification of proteins in complex samples
●●   Analysis of post-translational modifications
●●   Identification and dynamics of interacting proteins
●●   Stoichiometry and architecture of protein assemblies
●●   Quantification of targeted proteins
●●   Bioinformatics data analysis
CONTACTS
                    Scientific Director: Odile Schiltz
                        ,: proteomique@ipbs.fr
                      :: http://proteomique.ipbs.fr/
      For more information about our supports you can visit our website

                          R&D SERVICES
                For companies and academic laboratories
          Advice and expertise for a complete accompaniment
               Technical optimization to meet your needs
       State of the art techniques and strategies for the community
              Development of methodologies in proteomics

                 EDUCATION & TRAINING
                               Education:
                          Master, PhD programs
                             Training:
            Workshops and theoretical and practical courses

          INFRASTRUCTURE & NETWORKS
                          National IBiSA label
  (coordination of technological and research platforms in life sciences)
One of the three nodes of the National Infrastructure in Proteomics, ProFI
Metabolomics & Fluxomics

  Center of expertise
  in Metabolomics and
  Fluxomics

                 Visit our website
Skills and cutting-edge technologies for your
      projects in metabolomics and fluxomics

3 NMR Spectrometers : NMR 500, 600 and 800 MHz with cryprobes

4 sample preparation robots

15 Mass Spectrometers coupled to 12 LC and 3 GC

Specific softwares

Multidisciplinary expertise :
NMR, Mass spectrometry, bioinformatics, statistics, robotic,
biochemistry and metabolism.
Exploring metabolism

              Metabolite                                             Biomarker
      fingerprint analysis                                           Identification

                                   Statistics, Methamatics,
                                    Metabolic Networks

       Isotopic profiling                                            Quantification
          and fluxomics                                              of metabolites

                                                  The Metabolomics and Fluxomics Core
                                                  Facility of Toulouse (MetaToul) brings
                                                  together expertise (researchers, engineers,
                                                  technicians) and state-of-the-art equipment
                                                  (NMR, MS, robots) for the global analysis of
                                                  metabolism.

It provides the scientific community with
       the concepts, tools and methods to
    investigate metabolism at the level of a
   biological system (cell, tissue, organism).
CONTACTS
              Scientific Director: Jean-Charles Portais
                            Co-Directors:
             Justine Bertrand-Michel, Laurent Debrauwer
               ,: https://mama-webapp.metabohub.fr/
           :: https://www6.toulouse.inra.fr/metatoul_eng/
    For more information about our supports you can visit our website
                              : @metatoul

                            SERVICES
              For companies and academic laboratories
                           One-off services
                        Training for autonomy
        Advice and expertise for a complete accompaniment
      Technical development or adaptation to meet your needs

               EDUCATION & TRAINING
                             Education:
                        Master, PhD programs
                            Training:
            Workshops, theoretical and practical courses

         INFRASTRUCTURE & NETWORKS
 MetaToul is one of the initiators of MetaboHUB : the French National
 Infrastructure for Metabolomics & Fluxomics. It has been awarded the
IBiSA & CNOC labels and it is very active in the Réseau Francophone de
   Métabolomique et Fluxomique (RFMF) and in the Lipidomysts Network
Molecular Screening

      Ligand & Protein
      Screening Facility

            Visit our website
Multidisciplinary Services

                  Crystallography:
                  ■■ Crystallization and structure determination

                  ■■ In cristallo screening

                  NMR:
                  ■■ Liquid and solid state NMR

                  ■■ Structure determination and ligand screening

                  Biophysics:
                  ■■ Macromolecule characterization in solution

                  ■■ Screening of ligands and complex characterization

                  Chemistry:
                  ■■ Liquid, supercritical and ionic chromatography

                  ■■ Small organic molecule and peptide synthesis

                  Discovery of original enzymes:
                  ■■ Functional metagenomics; protein engineering

                  ■■ Enzyme purification and characterization

           PICT will adapt to your needs
in structural biology, screening and characterization
             of target-ligand interaction
From screening to molecular design

           Protein                  Stuctural             Ligand              Chemical
         optimization                Biology              design              synthesis

             Protein                3D structure      High Throughput
           engineering               of protein          Screening
      (rationnal, semi-rationnal,    (holo & apo)
                                                                            Chemical library
         directed evolution)
                                                     Chemical synthesis
                                                                               Fragment
            Enzyme                                                              library
        characterization                            Biophysical screening
                                                        NMR, RX, DSF
                                                       ITC, SEC-MALS

           Enzymatic
       activity screening                                                       Virtual
                                                      Virtual screening
                                                                            chemical library

                      A complete package of technologies
             for the identification and design of inhibitors/effectors
                   and the discovery and design of enzymes...

PICT combines the expertise of 3 facilities, all located in Toulouse (France):
■■   Institut de Pharmacologie et de Biologie Structurale (IPBS)
     Biophysics, structural biology and bioinformatics
■■   Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique
     (LSPCMIB)
     Chemical synthesis, analysis and purification
■■   Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (LISBP)
     Enzyme discovery and optimization
CONTACTS
      Directors: Laurent Maveyraud,Virginie Nahoum
                       ,: pict@ipbs.fr
                  :: http://cribligand.ipbs.fr/
For more information about our supports you can visit our website

                    SERVICES R&D
         For companies and academic laboratories
        One-off services with or without assistance
                   Training for autonomy
    Advice and expertise for a complete accompaniment
  Technical development or adaptation to meet your needs

           EDUCATION & TRAINING
                         Education:
                    Master, PhD programs
                       Training:
      Workshops and theoretical and practical courses

    INFRASTRUCTURE & NETWORKS
   PICT has been recognized at the national level (IBiSA,
   ChemBioFrance, IBISBA) and is integrated in GenoToul
               (i.e. the Toulouse Genopole)
Toulouse Réseau Imagerie

A platform to observe
living systems

                Visit our website
3 fields of shared skills

                Molecular imaging                Cellular imaging               T

               ELECTRON MICROSCOPY – Tomography, Cryo-methodology, CEMOV

  MICROSCOPY / ANALYSIS – Molecular interactions, FLIM, AFM, Microspectrofluorimet

     SUPER-RESOLUTION – STORM, STED, PALM, SIM, TIRF          MACROSCOPY/MICR

            CYTOMETRY, CELL SORTING & CYTO-IMAGING              2D to 4D LIGHT M

                                                 IMAGING PROCESSING & MODE

                                    The platforms of the
                                    TRI Genotoul imaging
                                      network combine
                                      skills and facilities
                                     to accompany you
                                     in developing your
ELECTRON MICROSCOPY                  scientific project in
                                         life sciences.

                                                                        CYTOM
                                                                      AND CELL
From molecule to organism

Tissular imaging                  Organism imaging

VIS, Unique molecules and X-ray analysis

 try, Optical tweezers

ROSCOPY – MacroSPIM, Intravital, Fluorescence and non-invasive luminescence

MICROSCOPY – Wide-field, SPIM, Confocal, Spinning disk, Multiphoton, Laser micro-dissection

ELING

                          Using electronic, light
                          or cytometry imaging
                             techniques, our
                           services range from
                           occasional helps to
                          the most comprehen-
                              sive support.                  LIGHT MICROSCOPY

METRY
L SORTING
CONTACTS
             Scientific Director : Olivier Gadal
         Operational Manager : Jacques Rouquette
                 ,: tricontact@genotoul.fr
                  :: http://trigenotoul.com
For more information about our supports you can visit our website

                    SERVICES R&D
         For companies and academic laboratories
        One-off services with or without assistance
                   Training for autonomy
    Advice and expertise for a complete accompaniment
  Technical development or adaptation to meet your needs

           EDUCATION & TRAINING
                          Education:
                    Master, PhD programs
                           Training:
      Workshops and theoretical and practical courses

    INFRASTRUCTURE & NETWORKS
                  ECellFrance infrastructure
               ImaBio, RCCM & AFC Networks
                          RT MFM
Animal Phenotyping

Explore pathophysiology
in vivo

                Visit our website
Develop and explore integrated models
   to understand pathophysiologies

                            CREATION
  ANIMAL FACILITY
                        OF ANIMAL MODELS

   EXPERIMENTAL
                          PHENOTYPING
   MICROSURGERY

SMALL ANIMAL IMAGING     HISTOPATHOLOGY

 CRYOPRESERVATION
                       BEHAVIOR / COGNITION
 DECONTAMINATION
Reasons to choose us

Anexplo’s technical platforms provide the public and private scientific communities with
state-of-the-art equipment and the necessary expertise to accompany you in the
generation, development and functional exploration of integrated animal models to
understand living organisms in their normal or pathological functioning.
■■   VARIOUS THEMES – Our expertise is in the areas of cardiovascular biology,
     metabolism, neuroscience, immunology, vaccinology, host-pathogen interactions and
     infectious diseases.
■■   BIOLOGICAL SECURITY – Our hosting and experimentation infrastructures make
     it possible to work in security levels 1,2 and 3.
■■   MANY MODELS – Rodents (mice and rats), lagomorphs (rabbits), sheep, cattle and
     birds (hens, ducks and turkeys).
■■   MULTIPLE TECHNICAL PLATFORMS:
     • CRISPR-Cas9
     • Orthotopic organ transplantations
     • Biochemical, hematological analysis
     • In vivo calorimetric and metabolic measurements
     • Non invasive in vivo imaging of small animals (Echography, IRM, TEP Spect, CT,
       bioluminescence)
     • Behavioral screening (Locomotor activity & fatigability, Anxiety, Coordination)
     • Cognitive Functions (Spatial and contextual Memory, social behavior and learning)
■■   PERMANENT IMPROVEMENT– Backed by public research laboratories, we
     conduct a continuous R & D activity. Our equipment remains at the forefront of
     non-invasive exploration and in vivo imaging.
■■   ANIMAL WELLBEING - Understanding human diseases, developing new drugs
     requires animal models. We ensure animal welfare by optimizing the conditions of
     stabling and experimentation according to national and international ethical rules.
CONTACTS
            Scientific Directors: Sylvie Guerder,
               Olivier Neyrolles, Éric Oswald
                   ,: anexplo@genotoul.fr
                :: https://anexplo.genotoul.fr/
For more information about our supports you can visit our website

                    SERVICES R&D
         For companies and academic laboratories
        One-off services with or without assistance
                   Training for autonomy
    Advice and expertise for a complete accompaniment
  Technical development or adaptation to meet your needs

           EDUCATION & TRAINING
                         Education:
                    Master, PhD programs
                       Training:
      Workshops and theoretical and practical courses

    INFRASTRUCTURE & NETWORKS
 Anexplo is a member of Equipex Aninfimip and Celphedia
  and RefBio networks: the guarantee to find an answer
                 to all your problems
Human Biobank

Human Biological
Resource Center

         Visit our website
Develop and explore integrated models
             to understand pathophysiologies

The CRBh platform, a center for human biological resources, brings together the
3 biobanks implemented by the Toulouse University Hospital (TUH): Toulouse
Bio-Resources, CRB-Cancer, Germethèque.
■■   Missions of CRBh:
     ●● preparation, packaging, storage of human biological resources and provision

        to investigators
     ●● management of samples as part of clinical investigation projects

     ●● central laboratory for multi-center programs: preparation and shipping of

        sampling kits
     ●● interface with the analytical platforms of the TUH’s laboratory

■■   CRBh operates according to a specific quality standard (standard NF 96-900),
     ensuring strict regulatory compliance, storage safety, computerized
     management of resources and associated data.
Reasons to choose us

■■   Toulouse Bio-Resources (CRB – TBR) includes over 40 collections developed
     around 3 major fields: 1 °) Ageing process: cognitive, neurological,
     cardiovascular, bone and metabolic disturbances; 2 °) Development and
     childhood diseases; 3 °) Infectious diseases. CRB-TBR manages and provides
     a variety of samples: blood and derivatives, genomic DNA, cerebrospinal fluid,
     urine, faeces, tissue biopsies, cultured cells.

■■   CRB-Cancer is dedicated to cancer diseases. CRB-Cancer has tumor tissue
     and non-tumoral / tumor-associated samples collected in 12 major areas:
     lymphomas, melanomas, tumors from brain, breast, lung, skin, bone, and soft
     tissues, urological, colorectal, gynaecological and neuroendocrine tumors.
     An associated histopathology platform is dedicated to research and develops
     immuno-histochemistry, in situ hybridization and tissue microarrays (TMA).

■■   GERMETHÈQUE – Biological resources concern fertility, procreation and
     human development. Among the specific resources are ovocytes, spermatozoa,
     follicular fluid, seminal plasma, germinal tissues, culture media from embryos…
CONTACTS
                   Scientific Coordinator: Bertrand Perret
                        ,: perret.b@chu-toulouse.fr
                    Operational Manager: Bénédicte Razat
                        ,: razat.b@chu-toulouse.fr
:: https://www.chu-toulouse.fr/-centre-de-ressources-biologiques-toulouse-bio-
         For more information about our supports you can visit our website

                             SERVICES R&D
                  For companies and academic laboratories
           Management of biological samples for clinical investigation
                      Central lab in multi-centre projects
             Advice and expertise for a complete accompaniment
           Technical development or adaptation to meet your needs

                    EDUCATION & TRAINING
                                 Education:
                              Masters, technicians
                                      Training:
                          Workshops and seminars for
              Investigators, clinical research Assistants and Nurses

             INFRASTRUCTURE & NETWORKS
     CRBh is a member of 3c.R, a club bringing together French biobanks
                              of human resources
      CRBh is associated to GIRCI-SOOM, the interregional grouping
       on clinical investigation in Southwestern France and overseas
Toulouse Plant-Microbe Phenotyping

          A high throughput plant
          phenotyping facility

                          Visit our website
A purpose-built construction with
 glasshouses, robots & instruments for
phenotyping whole plants in interaction
with their environment (biotic/abiotic)

                     The TPMP platform is dedicated to
                     automated, high throughput
                     phenotyping of model and agronomic
                     plants and their associated
                     microorganisms, in controled conditions.
                     It allows a non-invasive monitoring of
                     plants in simulated climatic and
                     environmental conditions. With S2
                     security conditions, it can be used with
                     GMOs and quarantine organisms.
TPMP Phenotyping offer

●●   High throughput phenotyping in dedicated growth-room
●●   High throughput phenotyping in greenhouse
●●   Microbial phenotyping – Biolog System
●●   RGB, infrared and fluorescence imaging
●●   Plant-microbe interactions
●●   S2 and quarantine conditions
●●   Image analyse
CONTACTS
             Scientific Director: Nemo Peeters
                       ,: tpmp@inra.fr
                      :: http://tpmp.inra
For more information about our supports you can visit our website

                    R&D SERVICES
          For companies and academic laboratories
         One-off services with or without assistance
                    Training for autonomy
    Advice and expertise for a complete accompaniment
  Technical development or adaptation to meet your needs

           EDUCATION & TRAINING
                         Education:
                    Master, PhD programs
                       Training:
      Workshops and theoretical and practical courses

    INFRASTRUCTURE & NETWORKS
          TPMP is part of the PHENOME/Emphasis
           France national phenotyping network
Ethics and Biosciences

Specialised in ethical,
legal and social issues

               Visit our website
A support for responsible research
                  and innovation in life sciences

The Genotoul Societal Platform is a multidisciplinary team, bringing its
expertise on the ethical, legal and societal aspects associated with biosciences,
in particular with regard to genomics and biotechnologies.

                 PUBLICS
                                            ●●   Researchers and Health Professionals
                                            ●●   Public institutions
                                            ●●   Private companies
                                            ●●   Teachers, doctoral students and students
                                            ●●   Associations
                                            ●●   General public

                                                                              AREAS
●●   Research involving humans, animals, plants and in robotics
●●   Genomic research, modification, editing and genetic testing
●●   Synthetic biology research and applications
●●   Informed consent in biomedical research
●●   Collection, storage and use of biological samples
     (eg embryonic stem cells), and associated data
●●   Innovative therapies (eg cell / gene therapies)
Expertise on the ethical, legal and societal
          issues associated with life sciences

                                             SERVICES*
                                             ●●   Personalised support on the ethical and
                                                  regulatory aspects for the submission of
                                                  health research projects (ANR, H2020…)
                                             ●●   Targeted expertise on specific questions

TRAINING
Addressed to PhD students and professionals
on the ethical and societal aspects of scientific
research

                                            WORKSHOPS
                                            Scientific animation open to everyone on
                                            issues related to genomics and
                                            biotechnologies

MONITORING
Publication of news on the platform’s website
on several topics related to ethics of health
research and innovation

                                                             * Prices and quotation on request
CONTACTS
               Scientific Director: Emmanuelle Rial-Sebbag
                       Co-leader: Gauthier Chassang
                         Coordinator: Lucie Serres
                          ,: societal@genotoul.fr
                       :: https://societal.genotoul.fr/
       For more information about our supports you can visit our website

                           R&D SERVICES
            For research companies and academic laboratories
        Expertise for one-off services or complete accompaniment
       Operational adaptation and counselling to meet your needs
                        Training for enhancing skills

                  EDUCATION & TRAINING
                                Education:
                           Master, PhD programs
                              Training:
             Workshops and theoretical and practical courses

           INFRASTRUCTURE & NETWORKS
      Societal is integrated in several Networks and Infrastructures:
        French Clinical Research Infrastructure Network (F-Crin)
Federative Institute of Interdisciplinary Studies and Research on Health and
                               Society (IFERISS)
                UNESCO Chair Science Ethics and Society
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