SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors

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SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
SenesTech, Inc.
     NASDAQ: SNES

      February 2020
 INVESTOR PRESENTATION
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
SenesTech Disclaimer
                                                                   SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS

The following information and the statements made during this presentation contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as
amended, and Section 21E of the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private
Securities Litigation Reform Act of 1995. Forward-looking statements describe future expectations, plans, results, or strategies and are generally preceded by words such as "may,"
"future," "plan" or "planned," "will" or "should," "expected," "anticipates," "draft," "eventually" or "projected." You are cautioned that such statements are subject to a multitude of risks and
uncertainties that could cause future circumstances, events, or results to differ materially from those in the forward-looking statements, including the risks that actual results may differ
materially from those projected in the forward-looking statements as a result of various factors and other risks identified in our filings with the Securities and Exchange Commission.

Forward-looking statements include, but are not limited to, our expectation regarding sales commitments, our expectation regarding the conversion of sales commitments and programs
to revenue, our belief that our product is more humane, less harmful to the environment and more effective than traditional methods, and our belief that ContraPest will establish a new
paradigm in rodent control without environmental effects of rodenticides.

All forward-looking statements contained in this presentation speak only as of the date on which they were made and are based on management's assumptions and estimates as of such
date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or
otherwise.

                                      ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                        Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                  2
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Recent Events
•   Q419 Preliminary Results: Q419 revenue of approximately $70,000 is nearly double Q319 revenue of $36,000.

•   Washington D.C.: Deployment continues to meet our expectations, as supported by camera studies.

•   Feather Facilities: Our projects in poultry farms expected to demonstrate both the economic value and efficacy of ContraPest as these
    projects reach six to nine months of deployment.

•   National Retail: Our project in national retail continues to expand to additional locations.

•   California AB1788: We continue to believe that AB1788 will resume its legislative progress in the current legislative session.

•   California Deployments: Our deployments in San Francisco and Los Angeles continue, with good consumption and possible expansion.

•   Sales & Marketing: We have identified and recruited a new head of sales and marketing with extensive experience in commercializing
    environmentally responsible pest control products.

•   Cost Control: Our goal has been to remove $1 million from the annual burn rate, and we are tracking well on that goal.

•   Registered Direct Stock Offering: On January 28, 2020, we announced the closing of a registered direct stock offering. Cash at the end of
    2019, pro forma for the inclusion of that offering, was $3.1 million.

                            ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                              Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                        3
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
The Addressable Challenges
                                                                         Challenge #1 Food Security
                                                                         Rodents destroy food through consumption and
                                                                         contamination. In 2014, 20% of stored food worldwide was                                                                         The total
                                                                         lost due to rodent activity. 2                                                                                           addressable rodenticide
                                                                                                                                                                                                  market is about $1 Billion
                                                                         Challenge #2 Infrastructure Damage                                                                                              annually. 1
                                                                         Rats damage public infrastructure, estimated by the
                                                                         National Wildlife Research Center (NWRC) at over $27
                                                                         billion annually in the U.S. 3
                                                                                                                                                                                                   How much more is it
                                                                         Challenge #3 Disease and Poison
                                                                                                                                                                                                  worth to effectively and
                                                                                                                                                                                                   safely address these
                                                                         Rodents transmit disease (>200 million deaths historically 4),
                                                                         deadly pathogens and poisons to animals and humans.                                                                           challenges?

1 Derived from Markets and Markets press release titled “Rodenticides Market worth 1.23 Billion USD by 2022”: https://www.marketsandmarkets.com/PressReleases/rodenticides.asp
2 QA Magazine, Commensal Rodents Eat at Our Tables, http://www.qualityassurancemag.com/article/qa1014-rodents-control-management/
3 ENVIRONMENTAL AND ECONOMIC COSTS OF VERTEBRATE SPECIES INVASIONS INTO THE UNITED STATES, DAVID PIMENTEL, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA.

https://www.aphis.usda.gov/wildlife_damage/nwrc/symposia/invasive_symposium/content/Pimentel2_8_MVIS.pdf
4 BBC News, Decoding the Black Death, http://news.bbc.co.uk/2/hi/health/1576875.stm

                                                                 ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                                                   Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                                             4
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Reproduction is the Source of Infestations

Chicagomag.com 2015; National Geographic How two rats become 15,000 in one year. [Video file]. (2013). Retrieved February 15, 2018, from https://www.youtube.com/watch?v=RJA4IW_pkeo

                                                  ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                                    Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                              5
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Lethal Campaigns Can Leave Opportunity for Rebound
                            120

                            100
 Population Abundance (%)

                                                                                                 Rebound

                             80
                                                                                                                                                                                                                                            Rat population
                                                                                                                                                                                                                                              response to
                             60                                                                                                                                                                                                              ContraPest®
                                                                                                                                                                                                                                            following lethal
                                                                                                                                                                                                                                               campaign.
                             40

                             20
                                                                                             Lethal campaign not 100% effective due to
                                                                                                     resistance, avoidance, etc.
                              0
                                  0          1           2            3          4       5        6        7       8        9      10       11       12      13       14      15       16       17      18       19      20       21      22       23
                                                                                                                                       Month
                                  Innes et al. 1995; SenesTech Internal Data                                                                                   Populations can rebound to initial size in 3-6 months, driving incremental costs,
                                                                                                                                                                          increased damage, and unforeseen resource allocation.

                                                                               ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                                                                 Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                                                               6
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Our Solution
ContraPest is a highly attractive, liquid bait containing the active ingredients
(“AI”) 4-vinylcyclohexene diepoxide, or VCD, and triptolide, a plant-derived                                                                             VCD
chemical, with a high fat content and sweet taste.

• Rats repeatedly feed, and their fertility is reduced as they consume the bait. The
  active ingredients target both male and female rodents resulting in sustained
  contraception with continued consumption
                                                                                                                                                        Triptolide
• Sustained impact and avoids population “rebound”
       • When lethal means are used, the death rate is always less than birth rate
         for rats
• Designed To Minimize Risk to Handlers, Non-targets And Other Animals

                         ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                           Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                     7
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Delivering an Effective Product: Lab Studies
• Multiple, free-choice laboratory studies have repeatedly demonstrated efficacy.
• No observable adverse effects.

   “If a rat consumes                                                                                                                                                                                     This has been confirmed in
 ContraPest, they do not                                                                                                                                                                                   laboratory and third party
       reproduce.”                                                                                                                                                                                                studies. (1)

             (1) Witmer, G., S. Raymond-Whish, R. Moulton, B. Pyzyna, E. Calloway, C. A. Dyer, L. P. Mayer, and P. Hoyer. 2017. Compromised fertility in free feeding of wild-caught Norway rats (Rattus norvegicus)
             with a liquid bait containing 4-vinylcyclohexene diepoxide and triptolide. Journal of Zoo and Wildlife Medicine 48:80-90.

                                ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                  Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                                        8
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Delivering an Effective Product: Field Studies
                                                               URBAN STUDIES
                                                               Results
                                                               •      Rats repeatedly consumed ContraPest® in the
                                                                      presence of rodenticides, trash, other food sources,
                                                                      exclusion strategies, and abundant water options.

                                                               • Reductions of up to 40-60% in 12 weeks.

                                                               • Non-standard spacing did not impact efficacy.

     ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
       Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                 9
SenesTech, Inc. NASDAQ: SNES INVESTOR PRESENTATION - February 2020 - Investors
Delivering an Effective Product: Field Studies
AGRICULTURAL STUDY

Results
• Rats consumed ContraPest® in the presence of
  rodenticides, animal feed, and abundant water options.

• Sites with ContraPest® displayed 46% lower signs of
  activity than just rodenticides alone.

• 100% of mature female rats on sites with rodenticide
  alone were found to be pregnant or lactating, versus 33%
  on sites with ContraPest.

                       ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                         Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                   10
Case Studies and Success Stories
                                                          • Hospitals
                                                          • Apartment buildings
                                                          • Zoos
                                                          • Animal sanctuaries
                                                          • Animal research and care facilities
                                                          • City parks
                                                          • Islands
                                                          • Food production facilities

 ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
   Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                             11
EPA Approved

ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
  Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                            12
Commercialization Strategy
ContraPest: The Anchor to IPM
               Prevention

Chemical                                       Biological
                                                                                                                                 ContraPest®

                                                                                                      ContraPest can be used as a standalone
                                                                                                       solution or within an Integrated Pest
                                                                                                      Management (IPM) plan to help reduce
Physical                                      Sanitation                                             reproduction and magnify the success of
               Mechanical
                                                                                                        infestation control methodologies.

           ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
             Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                       14
Market Approach
                                                                 ContraPest®

                                               Distributors

                                             Pest Management Professionals (PMPs)

                      Integrated Pest Management: ContraPest is one tool in the PMP toolbox.
Pull

                   Commercial /                                                                                     Corporate Social
                    Residential                      Government                         Agriculture                Responsibility (CSR)

              • Integrated Pest                   • Transit systems                 • Protein production            •   Eco-sensitive
                Management through                • Public Housing                  • Grain or food                 •   NGO partners
                Pest Management                   • Recycling/waste                   storage                       •   Sustainability
                Professionals (PMP)                 facilities                      • Organic                       •   Natural preserves and
              • Commercial                                                                                              zoos
              • HOAs, theme parks,
                animal care

       ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
         Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                   15
Evolved Market Approach
                        SenesTech Technical Account Sales, Pest Management Organizations

                                              Pull Customer Demand and Impact
       Structural/                      Animals           Food Production/          National Retailers                Hospitality
      Municipalities                Zoo, Sanctuaries        Food Storage

•   Commercial Structures       •   Zoos                 • Protein production       •   Distribution Centers   •   Eco-sensitive
•   HOAs                        •   Animal Parks         • Grain or food            •   Pet/Feed stores        •   Island Locations
•   Industrial                  •   Animal Sanctuaries     storage                  •   Fast Food Operations   •   Theme Parks
•   Cities, Transits            •   Animal Research      • Organic, Free Range      •   Mixed Commercial       •   Convention Centers
                                    Facilities           • Packing, Shipping,                                  •   Hotels
                                                           Storage

                                                           ContraPest®

                            Ship Direct                                                       Distributors

                  Internal Staff (Non- RUP)                                  Pest Management Professionals (PMPs)
Focus
“Focus” is the key to evolving from “emerging” to
“commercial”

• Three very specific target verticals, with specific
  messaging and marketing
• California is a great geography for focus.
    • AB1788 may accelerate penetration of that
         geography, but we are not waiting for legislation
• Control costs in order to spend wisely and strategically
• Avoid “shiny objects” - all else is on hold until we
  demonstrate success
Product Enhancements and Extensions

• Bait Stations                                         • Non-Liquid Formulations                                                          • Mice

                  ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                    Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                              18
Pipeline
                          PRODUCT                                                                                                              PRIMARY TARGET(S)                                                                    MARKET OPPORTUNITY

                           Additional Rodents                                                                                                                Mice, voles                                                        >60% of overall rodent market1

                           Boar taint                                                                                                                              Boars                                                                            $1.2 billion 2

                           Feral animal fertility control                                                                                    Feral Dogs, Cats and Hogs                                                                              $1.5 billion 3

                           Large Animal                                                                                                                   Whitetail Deer                                                                                        ?

                           Companion Animals                                                                                                           Dogs and/or Cats                                                                                         ?

1 2017 State of the Rodent Market, PCT Magazine
2 Internal estimate
3 ENVIRONMENTAL AND ECONOMIC COSTS OF VERTEBRATE SPECIES INVASIONS INTO THE UNITED STATES, DAVID PIMENTEL, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA. https://www.aphis.usda.gov/wildlife_damage/nwrc/symposia/invasive_symposium/content/Pimentel2_8_MVIS.pdf

                                                              ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                                                                Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                                                                                                                           19
Balance Sheet
                                   ($ in Millions)                                                                                                                     September 30, 2019

 On January 28, 2020,              Cash, cash equivalents and highly liquid investments                                                                                                            $3.9
   we announced the
 closing of a registered
  direct stock offering.           Total Assets                                                                                                                                                    $6.6
Cash at the end of 2019,
    pro forma for the
                                   Debt                                                                                                                                                            $0.4
    inclusion of that
   offering, was $3.1
         million.                  Common Equity                                                                                                                                                   $5.1

                                   Shares Outstanding                                                                                                                                              28.3

                                   Warrants Outstanding                                                                                                                                                9.6
                                    Pro forma including July public offering

                           ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                             Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                             20
Income Statement
                          ($ in Millions, except per share data)                                                                                Q3 2019                           Q2 2019

                          Revenue                                                                                                                 $0.04                             $0.02
    Preliminary
unaudited revenues        Operating Expenses                                                                                                        2.6                               2.3
  for the fourth
   quarter were
  approximately           Net loss                                                                                                                 (2.6)                             (2.3)
      $70,000
                          Net loss per share                                                                                                     $(0.09)                           $(0.09)

                          Adjusted EBITDA Loss (Non-GAAP)                                                                                         $(2.3)                            $(2.0)

                     ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                       Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                 21
SenesTech Investment Highlights
• A billion-dollar market with a multi-billion dollar impact

• A proprietary technology that has no direct competition

• Meets customer need for efficacy as well as service
  provider need for efficiency and profitability

• A management team that blends sound science, disruptive
  product commercialization and pest control industry
  experience

                      ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                        Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                  22
Thank You
                                                                              SenesTech
                                                                              23460 N 19th Ave., Suite 110
                                                                              Phoenix, AZ 85027

                                                                               Facebook.com/senestech
                                                                               Twitter.com/senestech
                                                                               LinkedIn.com/company/senestech-inc-/

                                                                               info@senestech.com
                                                                               928-779-4143
                                                                               www.senestech.com

ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
  Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                            23
Appendix
Management

Kenneth Siegel
                                                                                                          Kim Wolin                                             Charmonte Watkins
Chief Executive Officer,
                                                    Tom Chesterman                                        Executive Vice                                        Director of Regulatory
Director
                                                    Chief Financial Officer                               President Operations                                  Affairs

Bill Baker                                          Paul M. Palz                                          Brandy Pyzyna                                         Nick Murphy
Vice President Finance                              Vice President, Corporate                             Vice President, Scientific                            Vice President,
                                                    Controller                                            Operations                                            Manufacturing

                       ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                         Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                   25
Board of Directors

Jamie Bechtel, JD, PhD                                                   Delphine Francois Chiavarini                                                   Matthew Szot
Chair and Director                                                       Director                                                                       Director, Chair of the Audit Committee

Kenneth Siegel                                                           Marc Dumont                                                                    Julia Williams, M.D.
CEO and Director                                                         Director                                                                       Director

              ContraPest® is registered federally as a General Use Product when used as directed. However, in some states, due to applicator expertise, it is a Restricted Use Product.
                Please check with your local state regulatory agency to determine restriction status. Read and follow all label instructions for target species Norway and roof rats.
                                                                                                                                                                                                 26
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