UpdAte Allergy + Asthma - Transforming lives with innovative science and compassionate care - Stanford Medicine
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201 Allergy + Asthma Update Transforming lives with innovative science and compassionate care
You Give Us the Strength
to Provide the Hope
Allergies and asthma affect people everywhere, creating fear and
disrupting lives. Thanks to the support of our generous and dedicated
philanthropic community, we are making great progress in finding
the root causes of these diseases that will enable us to prevent and
treat them, bringing peace of mind to patients and their loved ones.
Table of Contents
Introduction..........................................................................................................1
1 Scientific Advances and Program Achievements..........................................2
2 Philanthropic Impact.....................................................................................18
3 Community Connections...............................................................................24
4 Clinical Impact................................................................................................26
5 Training the Next Generation........................................................................34
6 Global Vision...................................................................................................38
7 Funding Needs................................................................................................42
2 3
Bringing the Best to
Those Who Need it Most
I am so grateful to you. You, our amazing philanthropic community, have
For your foresight. Your responded with incredible kindness. Because of
generosity. Your dedication your partnership, we are not only expanding our
to ensuring every person Center’s innovative science and compassionate care,
with allergies or asthma we are also able to bring our expertise to children and
receives the best possible families in underserved communities. We have new
care and treatment. projects to help educate and empower patients and
their families and to inform public health policies that
At the Sean N. Parker Center for Allergy & Asthma will help protect them. We plan to increase our work in
Research at Stanford University, we are doing great this area, as we remain committed to curing allergies
team science, as you will read in these pages. We and asthma and improving the lives of all people
are using the latest available technologies to make everywhere who are affected by these diseases.
discoveries about molecular interactions in cells that
can lead to allergies and asthma. We are caring for Thank you again for all you do. As always, I look
many patients in our clinical research center who forward to sharing our progress with you personally
begin their trials terrified of eating or breathing in and hope to see you soon.
the wrong thing and emerge feeling confident and
All the best,
safer. We are working on ways to prevent allergies
as well as better and safer methods to diagnose
them. In fact, this year marks the 10th anniversary
of conducting these trials!
Kari C. Nadeau, MD, PhD, FAAAAI
Thanks to you, we collaborate with scientists
around the world and are involved in more than Director, Sean N. Parker Center for Allergy & Asthma Research
at Stanford University
100 research programs—searching for cures,
Naddisy Foundation Professor of Pediatric Food Allergy,
diagnostics, and better prevention—in many Immunology, and Asthma
countries, including South Africa, Australia, France,
Professor of Medicine and Pediatrics and, by courtesy,
China, Japan, Switzerland, Norway, and Russia. Otolaryngology at Stanford
This multiplies our impact across the globe as Section Chief, Asthma and Allergy
we try to answer remaining key questions about Division of Pulmonary & Critical Care
the international epidemics of allergy and asthma
Division of Allergy, Immunology, & Rheumatology
we currently face.
Member, Institute for Immunity, Transplantation and Infection
at Stanford
But all our wonderful breakthroughs and discoveries
Fellow, Stanford Center for Innovation in Global Health
won’t mean much if we can’t get them to the most
Faculty, Stanford Woods Institute for the Environment
vulnerable populations. To children in homeless
shelters and low-income neighborhoods facing
economic disparities. To families who have so many
stressors that a child with a food allergy, asthma, or
other allergy can tip them into a place where they
can’t cope. To those breathing polluted air and smoke
from wildfires that exacerbate allergies and asthma.
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1
SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Some key accomplishments Environmental Effects on Diagnostics
in 2018 included: Asthma and Allergies We have continued our efforts
Scientific Advances and Clinical Trials
Worsening air quality related to
climate change is having an impact
on asthma and allergies. Recent
to identify alternative diagnostic
methods that eliminate or
minimize the need for oral food
Program Achievements
We expanded our clinical trials,
launching 11 new studies in 2018. devastating wildfires in western challenges, currently considered
There were more than 1,000 North America have brought this the gold standard for diagnosing
clinical visits in 2018, with 189 danger closer to home. We are food allergies. We found that in
individuals newly screened, and looking at ways to offset the effects some patients, readily obtainable
86 adults and children enrolled of wildfires and airborne pollutants biomarker values (such as levels of
The Sean N. Parker Center for Allergy in new studies. Our biobank of on these diseases. IgE, an antibody involved in allergic
response, and the size of the irritated
specimens increased from 51,000
& Asthma Research harnesses scientific to nearly 72,000.
Using mass cytometry (CyTOF),
a powerful imaging and sorting
area after a skin prick) and patient
demographics can accurately predict
ingenuity and innovation to help people technology that measures dozens of the presence of a food allergy.
We conducted 14 unique molecular markers in single We also found that participants
with allergies and asthma worldwide. cells, we compared the immune with a history of asthma and high
clinical trials on peanut effects of wildfires and prescribed allergen-specific IgE have a higher
allergy, two on milk burns that are often used to control risk for severe reactions during
wildfires. In blood samples from food challenges.
allergy, and one on
By searching for causes, In 2018, our Center’s clinical and Our Center’s aims and children exposed to prescribed burns
basic science researchers continued approaches to trial design multiple food allergies. and those exposed to wildfires, Identifying those at risk of severe
preventions, and cures for to use state-of-the-art technology we found differences in immune reaction can help improve the safety
allergic disease, we assist to illuminate our understanding of
and patient care include: markers between the two groups. of food challenges. Knowing who is
the immune pathways of allergic We started trials using the novel The results were presented at the at risk allows us to give lower doses
patients—including the • Ensuring the active phase of drug drug fevipiprant (QAW039) for
responses. With critical support American Academy of Allergy, Asthma to these people. We developed a
vulnerable, the underserved, from our generous donors, we
therapy in a clinical trial is less uncontrolled asthma and & Immunology (AAAAI) meeting in food challenge severity score that
than a year for each patient,
and low-income tested the safety and efficacy of
reducing time constraints and
completed trials of risankizumab February 2019. Larger, controlled combines dose thresholds and
immunotherapy through clinical (BI 655066), a monoclonal antibody studies are needed to validate and allergic reactions to determine the
individuals—through commitments for participants. targeting the IL-23A protein, for risk of severe reaction in peanut
trials, using promising therapies fully understand these differences
insightful science and that can block molecular reactions • Helping patients improve severe, persistent asthma. We are so that the Center can assess the oral food challenges.
compassionate care. related to allergic inflammation. management of non-life- treating allergic rhinitis involving effect of prescribed burns on immune
threatening allergic reactions. dust mites using sublingual function and help develop guidelines
(under the tongue) immunotherapy for management of wildfires.
• Moving participants quickly off the and involving grass with injectable
wait list and into clinical trials. dupilumab, an antibody that blocks Our studies of teens exposed
• Hastening development of chemical messengers that mediate to high levels of air pollution in
diagnostic methods to replace inflammation. We are also using Fresno, CA, showed that increasing
food challenges, which can cause dupilumab to treat eosinophilic concentrations of fine particulates,
anxiety and be burdensome esophagitis (EoE), a chronic carbon monoxide, and nitrogen
for patients. allergic inflammatory disease of dioxide change the expression levels
the esophagus, which sometimes of immune factors involved in allergy
• Collaborating with industry occurs in patients on oral and asthma. We are expanding the
and nonprofit organizations immunotherapy (OIT). number of pollutants under study and
in exciting new studies.
are looking at their effects on fetuses
• Accelerating data-driven studies in the uterus and in children up to
using genomics, proteomics, For a list of clinical trials, age 2, as they are more sensitive to
metabolomics, and other “omics” see pages 30–33 in the Clinical pollutants because of their developing
to reveal molecular mechanisms Impact section of this update. immune systems.
that can help predict outcomes of
diagnosis and therapy.
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SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Molecular and Cellular Characterization Immunotherapy Technological Advances • AbSeq for detecting and
Immune Monitoring quantifying proteins in single
While OIT for food allergy has
been proven effective, protocols In 2018, our Center cells. AbSeq detects and
We improved our understanding of immune pathways quantifies proteins and genome
by investigating the unique immune traits of different have not been standardized. developed and used information in single cells at
Our Center has worked with the
patient populations. We found differences in the levels
European Academy of Allergy and
state-of-the-art ultrahigh throughput, allowing us
of certain immune cell types in umbilical cord blood
Clinical Immunology Task Force technologies that advance to analyze many more potential
between two ethnically different study groups of people allergens at a time than we can
in India and the United States. Using CyTOF, we also on Allergen Immunotherapy for our understanding of with other cytometry methods.
IgE-Mediated Food Allergy to develop
found immune cell differences between those with
evidence-based recommendations
allergies and asthma. We used AbSeq to look for
food allergy, asthma, food allergy and asthma, and
for immunotherapy protocols for Here are examples: molecular differences in
controls. Further investigations that build on this biomarkers of asthma in twins
immune cell knowledge will assist in understanding food allergens.
• Software automating with and without asthma.
the effect of these differences on health, which could Understanding why some people
meta-analysis of CyTOF data.
lead to the development of new treatments. Durability of Desensitization develop asthma and others do
We developed MetaCyto, a
With immunotherapy, most software that identifies commonly not can help us target specific
T Cells and B Cells in Food Allergy people need to continue to ingest labeled cell subsets across molecular mechanisms with
allergens to maintain desensitization. studies, enabling combined or drugs or other therapies.
We are working to identify different types of T cells
(white blood cells essential to the immune system) We are evaluating biomarkers to meta-analysis and increased
• Agglutination polymerase
involved in food allergy to better understand what causes help predict who can maintain statistical power. For example,
chain reaction. We have
allergic symptoms, find markers that could lead to better desensitization without continued we analyzed data from 10 different
developed this more sensitive
diagnosis, and determine how to safely block cellular ingestion. In a study of wheat OIT, cytometry studies that looked at
and specific method for measuring
pathways that induce allergic reactions. for example, we found that while the characteristics of cells. Using
IgE antibodies against specific
half the patients were desensitized nearly 2,900 samples, we detected
allergenic components in foods
There are two major types of T cells, CD4+ and CD8+, after one year on immunotherapy cellular differences between
with very small sample volumes.
which respond to peptides (short chains of amino acids) with wheat gluten, only 13 percent different demographic groups
This will help in identifying an
associated with allergens. It is well known that allergic remained desensitized eight to of patients.
allergen more accurately.
reactions involve CD4+ T cells, but we are the first to 10 weeks after discontinuing
demonstrate increases in CD8+ T cells in people with wheat gluten consumption. We • Single-nucleus RNA sequencing.
• Triggered by Offset,
peanut allergies. We also showed that these cells recognize are looking at blood samples to see We are collaborating with the team
Multiplexed, Accurate-Mass,
specific peanut-derived peptides that cause an allergic if there are molecular or genetic of Aviv Regev, PhD, chair of the
High-Resolution, and Absolute
reaction. After detecting and isolating CD8+ T cells that differences between those who faculty and core member of the
Quantification (TOMAHAQ).
arise in reaction to a particular allergen, we noted that remained desensitized and those Broad Institute of MIT and Harvard,
TOMAHAQ uses a synthetic
these T cells responded differently to allergens in people who became resensitized. to eventually use this technique
peptide trigger to quantify rare
with and without peanut allergy. This finding may enable to evaluate transcriptional
In another study, we compared critical peptides in a sample. We
better diagnoses and treatments. changes in DNA that occur in
differences in desensitization rates fine-tuned this method to identify
gastrointestinal cells in patients
in people consuming zero, 300, and biomarkers of atopic dermatitis
A study of patients with peanut allergies found that receiving OIT, potentially helping
1,000 milligrams of peanut protein a (eczema) and to determine
decreases in the IgE antibody during OIT, in conjunction to improve gastrointestinal
day after successful desensitization gastrointestinal leakage, helping
with the anti-IgE drug omalizumab, are accompanied treatment during OIT.
with OIT. Rates of desensitization to improve diagnoses.
by increases in IgG4, an antibody believed to reduce
allergic reactions. These two antibodies are produced were greater in those taking a • CRISPR-Cas9 gene editing.
by B cells. We isolated these B cells from people with maintenance dose (300- or 1,000-mg) We are collaborating with
food allergies and used single-cell RNA sequencing to than those who discontinued their Integrated DNA Technologies to
obtain insights into these cells and the antibodies they maintenance dose. Additionally, a use its CRISPR-Cas9 technology.
produce. These insights could lead to the development 300-mg dose was equally as effective By knocking out genes with
of drugs to enhance or block B-cell antibodies (IgG4 or as a 1,000-mg dose in maintaining CRISPR, we hope to determine
IgE, respectively) to reduce or halt allergic reactions. desensitization. the precise role of certain genes in
T cells from patients with asthma.
4 5
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SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
On the Path to Breakthroughs
Our Center’s laboratory team discovers and creates new ways to improve the lives of people
with allergies and asthma.
From Top Clockwise:
Researcher Wenming Zhang, PhD,
uses the confocal microscope
to create high-resolution digital
images of cells.
Diane Dunham, MS, researcher,
with the mass cytometry
(CyTOF) machine that determines
and analyzes cell properties.
Iris Chang, a data aide, inspects
vials of plasma and white blood
cells kept frozen in liquid nitrogen.
Bryan Bunning, Diane Dunham,
and Iris Chang work together to
advance research.
Some of the lab team in front
of the Biomedical Innovation
Building under construction that
will become our lab’s new home
in 2020.
Biological specimens from patients
in clinical trials are preserved and
stored for later research.
High-resolution microscope images
of cells are key to scientific insights.
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SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Disruptive Research Ruchi S. Gupta, Julie Parsonnet, Hans Oettgen, Our Center collaborates
MD, MPH, professor MD, professor of MD, PhD, associate with the Stanford Center for
Seed grants support of pediatrics at health research and chief of immunology Innovation in Global Health in
promising research that Northwestern policy at Stanford. at Boston Children’s supporting cutting-edge research
Medicine. Dr. Gupta analyzed data Dr. Parsonnet is studying how Hospital. Dr. Oettgen is looking at into global health problems
disrupts standard notions from a national survey to pinpoint microbes affect childhood growth
Justin L. Sonnenburg, PhD,
how the anti-inflammatory drug in resource-poor settings. We
associate professor of microbiology
and improves care and the prevalence, severity, and and immunity. She analyzed skin omalizumab, when used during support this seed grant:
and immunology, and Christopher
treatment for allergies distribution of food allergies. She samples from young children in Gardner, PhD, professor of medicine, oral immunotherapy (OIT), reduces
and asthma. found that 8 percent of U.S. children homes with and without detergents both at Stanford. In looking at how allergic reactions and speeds up Niaz Banaei, MD,
and 10.8 percent of U.S. adults and other cleansers containing the gut microbiome affects the desensitization to an allergen. associate professor
This research enables physicians have a food allergy, presenting a triclosan or triclocarban, two Among OIT patients allergic to of pathology and
immune system, Drs. Gardner and
and scientists to plant the seeds major public health issue. Forty-one antimicrobial agents often found peanuts, he found that those on medicine at Stanford.
Sonnenburg tested healthy adults
for medical breakthroughs. It percent of food-allergic children and in cleaning products. The immune omalizumab advanced more quickly
with two dietary interventions—one Dr. Banaei, working with Juan
expands the scientific and clinical 48 percent of food-allergic adults response in each group was on their increasing peanut doses
involving high-fiber foods and Santiago, PhD, Stanford mechanical
understanding of allergies and have multiple food allergies. She different, providing molecular and had fewer reactions than those
the other fermented foods rich in engineering professor, is developing
asthma, while exploring new identified higher food allergy rates evidence that killing off microbes in the placebo group. Patients
microbes. Those eating fermented a test using cell-free DNA (cfDNA)
technologies and methods in black children and in racial and with triclosan or triclocarban receiving the drug had significant
foods such as yogurt and cottage to detect tuberculosis (TB). CfDNA
for treating these disorders. ethnic minority adults, compared decreases in their peanut-specific
is associated with higher prevalence cheese experienced broad increases contains fragments of nucleic acids
Seed funding grows well in the with whites. of eczema and food allergies—also in microbial diversity and improved IgE antibodies, while placebo found in the non-cellular parts of
fertile soil of scientific innovation known as the “hygiene hypothesis.” immune health, with fewer signs subjects did not. The conclusion: blood and other fluids. Already used
at Stanford. Your gifts are critical 2016 of inflammation. In those eating OIT is enhanced by blocking either in prenatal testing, oncology, and
in fostering emerging studies that 2017 high-fiber foods, changes in the IgE function or the activation of transplantation, cfDNA is promising
would otherwise not happen. Jayakar V. Nayak, microbiome and immune system inflammation-producing cells— as an indicator of TB and other
MD, PhD, associate Stephen Luby, MD, were more varied. More studies called mast cells and basophils— infectious diseases. The team is
Our Center has awarded professor of professor of medicine need to be done before diet-based triggered by IgE. This study is one exploring its use as a non-invasive,
seed grants to the following otolaryngology at at Stanford. Dr. Luby of the first to show, from a molecular affordable tool for TB diagnosis
treatments can be designed.
researchers: Stanford. Dr. Nayak is studying nasal is investigating how standpoint, why blocking IgE not from readily available blood and
and sinus disorders such as chronic air pollution from kilns in Bangladesh only speeds up dose escalation for urine samples, especially from adults
2015 2018
rhinosinusitis (CRS). In one study, affects asthma and other respiratory OIT but also may enhance immune and children in developing countries.
patients with nasal polyps received and cardiovascular diseases. A field tolerance of allergens. The researchers have developed a
Gary Darmstadt, MD,
Mübeccel Akdis, glucocorticoids, a type of steroid team is monitoring particulates in the microchip to purify cfDNA from a
MS, associate dean
MD, PhD, head of hormone. This led to an increase air and interviewing individuals about drop of plasma and are assessing
dermatology at the for maternal and child
of T regulatory cells in the polyps, their health, gathering demographic the accuracy of their test.
Swiss Institute of health at Stanford.
suggesting that T cells are critical to and socioeconomic information, and
Allergy and Asthma Research. Dr. Darmstadt is studying the use
fighting inflammation and shrinking collecting health measurements.
Dr. Akdis is looking at how respiratory of skin emollients (an ingredient in
polyps. A second study found that Kilns for brick manufacturing operate
viruses can interfere with immune moisturizers) on infants in developing
some CRS patients’ nasal tissue had only in the dry winter months. Data
pathways. She analyzed T cells and countries to prevent or limit eczema,
a significantly greater population will compare health outcomes in the
B cells of asthmatic and healthy asthma, and food allergies. He uses
of B cells containing IgD antibodies, “on” and “off” seasons and across
people before and after experimental an emollient of low-cost ingredients
signaling proteins made by the households at varying distances
infection with rhinovirus, which that can be easily and reliably
immune system. This suggests IgD from brick kilns. The results will
causes the common cold. Infection can help enhance mucosal immunity provide much-needed evidence on manufactured. He is overseeing its
created anti-viral responses in T at mucus-producing sites in the the effects of air pollution on asthma, testing on newborns in Bangladesh
cells and B cells of both groups, but body or, by contrast, create an pulmonary disease, and hypertension as a skin barrier repair therapy that
responses were stronger in people inflammatory response. in Bangladesh. wards off eczema and the progression
with asthma. She showed how the to asthma, food allergies, and allergic
molecular mechanisms behind anti- rhinitis. Successful results could
viral reactions differed in people with lead to an affordable, effective way
asthma and those without the disease. to reduce the toll of allergies in
children worldwide.
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SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Our 2018 Scientific Advisors Howard Chang, MD, PhD, director, Robert Harrington, MD, Arthur L. Cathryn Nagler, PhD, Bunning
Center for Personal Dynamic Bloomfield Professor of Medicine and Food Allergy Professor, University
Our Scientific Advisory Regulomes, Stanford chair of medicine, Stanford of Chicago
Committee brings together Yueh-hsiu Chien, PhD, professor Lynn Hildemann, PhD, chair of Mark Nicolls, MD, chief of pulmonary
the best minds in allergy of microbiology and immunology, civil & environmental engineering, and critical care medicine, Stanford
and asthma science. These Stanford Stanford Engineering
Garry Nolan, PhD, Rachford
world-renowned scientists R. Sharon Chinthrajah, MD, director, Robert Jackler, MD, Edward C. and Carlota A. Harris Professor of
and doctors with different Clinical Translational Research Unit of and Amy H. Sewall Professor and chair microbiology and immunology,
specialties contribute their the Sean N. Parker Center for Allergy of otolaryngology, Stanford Stanford
& Asthma Research, Stanford
insights and expertise to Theodore Jardetzky, PhD, professor Julie Parsonnet, MD, George
create major advances in Mark Cullen, MD, director, Center for of structural biology, Stanford DeForest Barnett Professor in Medicine
treatments and therapies. Population Health Sciences, Stanford and professor of health research and
Purvesh Khatri, PhD, associate policy, Stanford
Carla Davis, MD, chief of immunology, professor, Stanford Institute for
Kari Nadeau, MD, PhD, director of allergy, and rheumatology, Texas Immunity, Transplantation, and Bali Pulendran, PhD, Violetta L.
the Sean N. Parker Center for Allergy Children’s Hospital Infection Horton Professor and professor of
& Asthma Research, Stanford microbiology and immunology,
Mark Davis, PhD, director, Chaitan Khosla, PhD, director of Stanford
Sean Parker, philanthropist,
Stanford Institute for Immunity, chemistry, engineering, and medicine
entrepreneur, founder, and president
Transplantation, and Infection for human health and Wells H. Rauser Stephen Quake, MS, PhD,
of the Parker Foundation
and Harold M. Petiprin Professor, Lee Otterson Professor, Stanford
Manisha Desai, PhD, director, Stanford Engineering Engineering, and professor of
Quantitative Sciences Unit, Stanford bioengineering, Stanford Medicine
Cezmi Akdis, MD, PhD, director,
Gideon Lack, MD, professor of
Swiss Institute of Allergy and
Noah Diffenbaugh, PhD, Kara J. pediatric allergy, King’s College Marc Rothenberg, MD, PhD, director
Asthma Research
Foundation Professor and Kimmelman London of allergy and immunology, Cincinnati
Family Senior Fellow, Woods Institute Children’s Hospital Medical Center
Mübeccel Akdis, MD, PhD, head
for the Environment, Stanford Mary Leonard, MD, MSCE, chair
of dermatology, Swiss Institute of
of pediatrics, Stanford, and Adalyn Lucy Shapiro, PhD, director,
Allergy and Asthma Research
Chris Field, PhD, Perry L. McCarty Jay Physician-in-Chief, Lucile Packard Beckman Center for Molecular &
Director, Woods Institute for the Children’s Hospital Stanford Genetic Medicine, Stanford
Michele Barry, MD, director,
Environment, Stanford
Center for Innovation in Global
Donald Leung, MD, PhD, head of Michael Snyder, PhD, director
Health, Stanford
Stephen Galli, MD, Mary Hewitt pediatric allergy and immunology, of the Center for Genomics and
Loveless, MD, Professor and professor National Jewish Health, Denver Personalized Medicine, Stanford
Scott Boyd, MD, PhD, associate
of pathology, Stanford
professor of pathology, Stanford
David Lewis, MD, chief of Justin Sonnenburg, PhD, associate
Christopher Gardner, PhD, Rehnborg pediatric allergy, immunology, and professor of microbiology and
Bruce Cain, PhD, Spence and Cleone
Farquhar Professor of medicine, rheumatology, Stanford immunology, Stanford
Eccles Family Director, Bill Lane Center
Stanford Prevention Research Center
for the American West, Stanford
Holden Maecker, PhD, director, Dale Umetsu, MD, PhD, principal
Ruchi S. Gupta, MD, MPH, Human Immune Monitoring medical director, Genentech, and
Carlos Camargo Jr., MD, DrPH,
director of Science and Outcomes Center, Stanford clinical professor of pediatrics, UCSF
Conn Chair in Emergency Medicine,
of Allergy and Asthma Research
Massachusetts General Hospital
(SOAAR), Northwestern University Lloyd Minor, MD, Carl and Elizabeth Steven Ziegler, PhD, director of
Feinberg School of Medicine and Naumann Dean, Stanford Medicine immunology research, Benaroya
Ann & Robert H. Lurie Children’s Research Institute
Hospital of Chicago
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SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Peer-Reviewed Journal Articles
Our Center’s contribution to allergy and asthma research in 2018 and early
2019 included 37 articles related to asthma, allergies, and immunology,
published in peer-reviewed journals.
2018 Publications Analysis of a large standardized food challenge IgE blockade during food allergen The use of biomarkers to predict aero-allergen
data set to determine predictors of positive ingestion enhances the induction of inhibitory and food immunotherapy responses.
High-affinity allergen-specific human antibodies outcome across multiple allergens. IgG antibodies. Sindher S, Long A, Acharya S, Sampath V, Nadeau KC.
cloned from single IgE B cell transcriptomes. Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, CLINICAL REVIEWS IN ALLERGY AND
Croote D, Darmanis S, Nadeau KC, Quake SR. Andorf S, Tupa D, Kumar D, Woch MA, O’Laughlin KL, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, IMMUNOTHERAPY.
SCIENCE. Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider L, 2018 Oct;55(2):190-204.
2018 Dec 14;362(6420):1306-1309. Wang J, Galli SJ, Nadeau KC, Chinthrajah RS. Oettgen HC.
FRONTIERS IN IMMUNOLOGY. ANNALS OF ALLERGY, ASTHMA AND IMMUNOLOGY. Eliciting dose and safety outcomes from a large
Predicting development of sustained 2018 Nov 27;9:2689. 2018 Nov 4. [Epub ahead of print]. dataset of standardized multiple food challenges.
unresponsiveness to milk oral immunotherapy Purington N, Chinthrajah RS, Long A, Sindher S,
using epitope-specific antibody binding profiles. Baseline gastrointestinal eosinophilia is common Thirdhand smoke component can exacerbate Andorf S, O’Laughlin K, Woch MA, Scheiber AJ,
Suárez-Fariñas M, Suprun M, Chang HL, Gimenez G, in oral immunotherapy subjects with IgE- a mouse asthma model via mast cells. Assa’ad A, Pongracic J, Spergel J, Tam J, Tilles S,
Grishina G, Getts R, Nadeau KC, Wood RA, Sampson HA. mediated peanut allergy. Yu M, Mukai K, Tsai M, Galli SJ. Wang J, Galli SJ, Desai M, Nadeau KC.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Wright BL, Fernandez-Becker NQ, Kambham N, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. FRONTIERS IN IMMUNOLOGY.
2018 Dec 7. [Epub ahead of print]. Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim 2018 Nov;142(5):1618-1627.e9. 2018 Sept 21;9:2057.
KP, Bunning B, Doyle AD, Jacobsen EA, Boyd SD,
Identification of almond (prunus dulcis) vicilin Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Peanut-specific T cell responses in patients Comparison of sublingual immunotherapy and
as a food allergen. Chinthrajah RS. with different clinical reactivity. oral immunotherapy in peanut allergy.
Huilian C, Zhang Y, Lyu SC, Nadeau KC, McHugh T. FRONTIERS IN IMMUNOLOGY. Birrueta G, Tripple V, Pham J, Manohar M, James EA, Zhang W, Sindher S, Sampath V, Nadeau KC.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2018 Nov 22;9:2624. Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V. ALLERGO JOURNAL INTERNATIONAL.
2018 Dec 4. [Epub ahead of print]. PLOS ONE. 2018 Sept;27(6):153-161.
AR101 Oral Immunotherapy for Peanut Allergy. 2018 Oct 10;13(10):e0204620.
The public health impact of parent-reported PALISADE Group of Clinical Investigators, Vickery BP, MetaCyto: A tool for automated meta-analysis
childhood food allergies in the United States. Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Multicenter, randomized, double-blind, of mass and flow cytometry data.
Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, placebo-controlled clinical trial of vital wheat Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee HC,
Jiang J, Davis MM, Nadeau KC. Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez gluten oral immunotherapy. Gherardini PF, Spitzer MH, Thomas CG, Campbell
PEDIATRICS. MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Nowak-Węgrzyn A, Wood RA, Nadeau KC, Pongracic J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP,
2018 Dec;142(6). Sussman G, Chinthrajah RS, et al. JA, Henning AK, Lindblad RW, Beyer K, Sampson HA. Bhattacharya S, Butte AJ.
NEW ENGLAND JOURNAL OF MEDICINE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. CELL REPORTS.
2018 Nov 22;379(21):1991-2001. 2018 Oct 4. [Epub ahead of print]. 2018 Jul 31;24(5):1377-1388.
Laundry detergents and detergent residue after
rinse directly disrupt tight junction barrier
integrity in human bronchial epithelial cells. Differences in multiple immune parameters Degradation of monocyte chemoattractant Realizing the Paris climate agreement to
Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, between Indian and U.S. infants. protein-1 by tryptase co-released in improve cardiopulmonary health: Where science
Acharya S, Altunbulakli C, Westermann P, Dreher A, Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra immunoglobulin dependent activation of meets policy.
Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani primary human cultured mast cells. Rice MB, Malea NM, Pinkerton KE, Schwartz J, Nadeau
Akdis CA. HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tam IYS, Ng CW, Lau HYA, Tam SY. KC, Browner CM, Whitehouse S, Thurston GD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT. INTERNATIONAL ARCHIVES OF ALLERGY ANNALS OF THE AMERICAN THORACIC SOCIETY.
2018 Nov 27. [Epub ahead of print]. PLOS ONE. AND IMMUNOLOGY. 2018 Jul;15(7):791-798.
2018 Nov 16;13(11):e0207297. 2018 Oct;177(3):199-206.
12 13
1
SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Peer-Reviewed Journal Articles
(continued from page 13)
Development of a tool predicting severity of Impact of allergen immunotherapy in
allergic reaction during peanut challenge. allergic asthma.
Chinthrajah RS, Purington N, Andorf S, Rosa JS, Zhang W, Lin C, Sampath V, Nadeau KC.
Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, IMMUNOTHERAPY.
Desai M, Nadeau KC. 2018 Jun;10(7):579-593.
ANNALS OF ALLERGY, ASTHMA AND IMMUNOLOGY.
2018 Jul;121(1):69-76.e2. Isotype-specific agglutination-PCR (ISAP):
a sensitive and multiplex method for
High dimensional immune biomarkers measuring allergen-specific IgE.
demonstrate differences in phenotypes and Tsai CT, Mukai K, Robinson PV, Gray MA,
endotypes in food allergy and asthma. Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS,
Chinthrajah RS, Purington N, Sampath V, Andorf S, Nadeau KC, Bertozzi CR, Galli SJ.
Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
ANNALS OF ALLERGY, ASTHMA AND IMMUNOLOGY. 2018 May;141(5):1901-1904.e15.
2018 Jul;121(1):117-119.e1.
EAACI guidelines on allergen immunotherapy:
Heterogeneity of Ara h component-specific CD4 T IgE-mediated food allergy.
cell responses in peanut-allergic subjects. Pajno GB, Fernandez-Rivas M, Arasi S,
Renand A, Farrington M, Whalen E, Wambre E, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K,
Bajzik V, Chinthrajah RS, Nadeau KC, Kwok WW. Bindslev-Jensen C, Burks W, Ebisawa M,
FRONTIERS IN IMMUNOLOGY. Eigenmann P, Knol E, Nadeau KC, et al.
2018 Jun 25;9:1408. ALLERGY.
2018 Apr;73(4):799-815.
Imaging FITC-dextran as a reporter for
regulated exocytosis. New treatment directions in food allergy.
Klein O, Roded A, Hirschberg K, Fukuda M, Galli SJ, Sampath V, Sindher S, Zhang W, Nadeau KC.
Sagi-Eisenberg R. ANNALS OF ALLERGY, ASTHMA AND IMMUNOLOGY.
JOURNAL OF VISUALIZED EXPERIMENTS:JOVE. 2018 Mar;120(3):254-262.
2018 Jun 20;(136).
Mast cells as sources of cytokines, chemokines,
Genetic and imaging approaches reveal and growth factors.
pro-inflammatory and immunoregulatory roles Mukai K, Tsai M, Saito H, Galli SJ.
of mast cells in contact hypersensitivity. IMMUNOLOGICAL REVIEWS.
Gaudenzio N, Marichal T, Galli SJ, Reber LL. 2018 Mar;282(1):121-150.
FRONTIERS IN IMMUNOLOGY.
2018 Jun 5;9:1275.
14 151
SCIENTIFIC ADVANCES AND PROGRAM ACHIEVEMENTS
Peer-Reviewed Journal Articles
(continued from previous page)
Anti-IgE treatment with oral immunotherapy in Changing patient mindsets about
multifood allergic participants: A double-blind, non-life-threatening symptoms during oral
randomised, controlled trial. immunotherapy: A randomized clinical trial.
Andorf S, Purington N, Block WM, Long AJ, Tupa D, Howe LC, Leibowitz KA, Perry MA, Block W,
Brittain E, Spergel AR, Desai M, Galli SJ, Nadeau KC, Kaptchuk TJ, Nadeau KC, Crum AJ.
Chinthrajah RS. JOURNAL OF ALLERGY AND CLINICAL
THE LANCET GASTROENTEROLOGY AND IMMUNOLOGY: IN PRACTICE.
HEPATOLOGY. 2019 Jan 22. [Epub ahead of print].
2018 Feb;3(2):85-94.
Prenatal exposure to mercury in relation
to infant infections and respiratory symptoms
Jan 2019 Publications
in the New Hampshire Birth Cohort Study.
A Phase 2 randomized controlled multisite Emeny RT, Korrick SA, Li Z, Nadeau KC, Madan J,
study using omalizumab-facilitated rapid Jackson B, Baker E, Karagas MR.
desensitization to test continued vs discontinued ENVIRONMENTAL RESEARCH.
dosing in multifood allergic individuals. 2019 Jan 11;171:523-529.
Andorf S, Purington N, Kumar D, Long A, O’Laughlin K,
Sicherer S, Sampson H, Cianferoni A, Whitehorn TB, Report from the National Institute of
Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Allergy and Infectious Diseases workshop
Desai M, Galli SJ, Rael E, Assa’ad A, Chinthrajah RS, on “Atopic dermatitis and the atopic march:
Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Mechanisms and interventions.”
Nadeau KC. Davidson WF, Leung DYM, Beck LA, Berin CM,
LANCET ECLINICAL MEDICINE. Boguniewicz M, Busse WW, Chatila TA, Geha RS,
2019 Jan; 7:27-48. Gern JE, Guttman-Yassky E, Irvine AD, Kim BS,
Kong HH, Lack G, Nadeau KC, et al.
Blockade of repulsive guidance molecule JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
b (RGMb) inhibits allergen-induced 2019 Jan 9. [Epub ahead of print].
airways disease.
Yu S, Leung KM, Kim HY, Umetsu SE, Xiao Y, Albacker Prevalence and severity of food allergies
LA, Lee HJ, Umetsu DT,Freeman GJ, DeKruyff RH. among US adults.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Gupta RS, Warren CM, Smith BM, Jiang J,
2019 Jan 28. [Epub ahead of print]. Blumenstock JA, Davis MM, Schleimer RP,
Nadeau KC.
Allergen-specific CD8+ T cells in peanut- JAMA NETWORK OPEN.
allergic individuals. 2019 Jan 4;2(1):e185630.
Yu W, Zhou X, Dunham D, Lyu S, Manohar M,
Zhang W, Zhao F, Davis MM, Nadeau KC.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
2019 Jan 22. [Epub ahead of print].
16 172
PHIL ANTHROPIC IMPACT
Philanthropic Impact Thanks to you, we can explore the tiniest changes in a cell. Use vaccines
to try to cure food allergy. Treat children and empower families. Document
The loving arms of your generosity the effects of pollution and climate change on children’s health. Discover
embrace and protect children and the best and fastest treatments for allergies and asthma. We are grateful for
families in need. your leadership into an allergy- and asthma-free future.
Many Thanks! The Bunning family has established
a new fund to address the flexible
Some of our most dedicated needs of food allergy and
partners have made incredible immunology research, and the
contributions to new and Domansky family also made an
continuing science and important gift to support food
outreach projects in 2018. allergy and asthma research at
our Center. An investment in basic
Thanks to many generous science and bioinformatics by the
supporters, we are moving into Hill family will be crucial to train
a new laboratory space in the new researchers and discover
Biomedical Innovation Building new therapies that can transform
at Stanford soon after its scheduled the lives of patients with allergies
completion in spring of 2020 and asthma. A generous gift from
(pictured top left). the Freidheim family will help
us continue treating children in
The Friend family made a key gift underserved communities.
for research into the molecular
mechanisms in wheat allergy with We express our continuing
the eventual goal of developing a gratitude to Sean N. Parker, Julia
vaccine for this disease. The and David Koch, Michele and Tim
Olsen-Small family supported a Barakett, Rebecca and Sacha
joint investigation with Boston Lainovic, The Safe + Fair Food
Children’s Hospital at Harvard Company, End Allergies Together
Medical School to improve (EAT), Food Allergy Research and
diagnosis of food allergies, and an Education (FARE), and the National
anonymous donor made possible a Institutes of Health (NIH) for
clinical trial at Mayo Clinic Arizona supporting our work in 2018.
to see if a biologic drug would help
patients using OIT who develop
severe stomach problems.
18 192
PHIL ANTHROPIC IMPACT
Helping Others Find Peace of Mind “We have a lot to look forward to because of the amazing research that’s been done so far and
because of the courage of those who come to our clinic. No one person can do this in a lifetime.
Inspiring stories, in their own words, from some of our courageous and generous donor families. We all need to work together.” — Dr. Nadeau
NEW YORK
CALIFORNIA
CALIFORNIA
ILLINOIS
Karmely Family Orsak Family Laaker Family Friend Family
Shahab, Eskander, Libby, Max Nicole Micah, Ben Matthew, Linda, Bill
When we first met Dr. Nadeau at a coffee shop, she asked Nicole was initially hesitant to start her oral My family’s lives changed dramatically when my youngest Although we noticed warning signs such as “hives”
Eskander, then in second grade, “What do you want to be immunotherapy trial. Diagnosed with multiple food son, Ben, was diagnosed with tree nut allergies when he was when he teethed on a bagel, the reality of our son’s
able to do after this study?” He looked at the display of treats. allergies as a baby, she learned to read every ingredient 2. After accidentally eating a cashew, he immediately began wheat allergy did not hit us until Matthew had his first
“I want to be able to eat one of those,” he said. “Not anything on a food label and was very careful about what she ate, struggling to breathe. At first, we thought he was choking. anaphylactic reaction at age 4. We didn’t know that being
with nuts. Just one that could have been near nuts.” especially peanuts. But just before her trial, she’d had a In fact, he was having a severe allergic reaction. allergic to wheat was serious or that wheat was in almost
serious allergic reaction after eating a piece of chocolate everything in our pantry. The emergency room doctor
For years, our son and our whole family had lived in constant with trace amounts of peanut and cashew. She did not Fortunately, his mother recognized the signs of anaphylactic directed us to avoid any potential allergens—wheat, oat,
fear. Eskander had multiple severe food allergies, including know if she could handle eating the food that made shock and called an ambulance. While waiting for the barley, rye—always carry epinephrine auto-injectors, and
nuts, dairy, and egg. Until he was 2, we wouldn’t let anyone her so sick. Dr. Nadeau gently reassured Nicole she paramedics, Ben was covered in hives, struggling to remain stay within 20 minutes of a U.S.-based health center. The
touch him. We were afraid something someone had eaten would be safe. alert as his airways constricted. It was terrifying. We do constraints suddenly became very real and very scary.
and had on their hands might be absorbed through his skin everything possible to keep a reaction from happening
and send him into anaphylactic shock. Many people told The treatment went slowly. Nicole often had severe again. School potlucks, playdates, and birthday parties We did everything we could to keep Matthew from
us Eskander was too allergic to be helped by treatment. We stomach pain. At times she almost gave up. Each time, are a minefield. Ben is always accompanied by a parent or eating anything that might cause a reaction, but still
traveled to Israel seeking different options. Nothing worked. Dr. Nadeau worked with us to address Nicole’s symptoms. another adult trained to use an epinephrine auto-injector. we lived in fear for Matthew’s life in case of accidental
When we heard Dr. Nadeau speak at an event, we were in After two years, Nicole was able to eat almost 16 peanuts Now almost 8, Ben is much more aware of and frustrated by wheat ingestion. We learned from an acquaintance—
awe. When we received a call from Stanford saying we would without having a reaction. We were all ecstatic. For the the restrictions he has compared to those of his friends. now a good friend—about a researcher in California doing
be in a trial, it was the most exciting moment of my life. first time in her life, our 13-year-old daughter walked pioneering work in food allergies. Dr. Nadeau and her
into a bakery, selected a cupcake, and ate it with a big After Ben’s allergic reaction, I shared his story with my team changed Matthew’s life forever. As a young adult,
Treatment was hard. Eskander was scared. But we are grin. The milestones continued: No more food labels. colleagues at Google and Ben’s mother learned about the his daily maintenance dose of wheat continues to protect
so grateful. Since he finished treatment, Eskander has Trips without her parents. Her first football game. Most Center’s pioneering work. I set up fundraising efforts for him. He now eats anywhere, with anyone, at any time.
completely blossomed. He’s interested in science, he’s importantly, she applied to college without having to the Center every year through our annual charitable giving
outgoing. We can see a complete change in his personality worry about needing fast access to medical care. drive. We support Dr. Nadeau because we want to give Ben We support Dr. Nadeau because she is not only a brilliant
and outlook on life. We recently took a family trip to and kids like him the best chance at happy, healthy, and researcher and fearless pioneer. She is also a mom—
Iceland that would have never been possible before the We believe in making a better world for people, especially more carefree lives. We fervently believe in a world where someone who truly understands what it means to treat
trial. Every child should live without fear of food. We children with food allergies. Food allergy is an invisible no one would have to experience a loved one struggling the whole person, work with the entire family, and
believe in the research at Stanford that Dr. Nadeau is disease with life-threatening consequences. Now that to hang on—as Ben did years ago—or worse. Ben is sharing remain tireless in search of more treatment options
leading. We want to help. Nicole is desensitized to peanuts, we want to support his story because, he says, “If it helps other kids not have and, we hope, one day, a cure.
new ways of addressing food allergies that will help to live with allergic reactions, it’s all worth it.”
other families.
20 212
PHIL ANTHROPIC IMPACT
Ripples on a Pond
Endowed gifts and continuing support help improve the lives of children with allergies
and asthma and their families for many years. Your kindness and commitment allow us to
sustain successful programs and begin new ones.
Investigating Allergies and Bringing Hope to Those in Need Supporting Leaders,
Asthma: from Basic Science Many families from across the Attracting Top Talent
to Treatments nation, like the Canfield family, are An anonymous donor and the
Thanks to gifts from families generously supporting programs for Barakett, Bravo, and Soffer families
committed to ending allergies and underserved children in California, are supporting early and senior
asthma, our Center is able to continue Chicago, and New York. Thanks to career researchers conducting
basic science research studies of their kindness, staff from our Center basic science investigations in our
the cellular changes involved in have been able to offer health and lab, including Scott Boyd, MD, PhD,
these illnesses and the best ways wellness workshops focused on who is studying the role of B cells in
to circumvent those changes. Our asthma and allergy prevention immune reactions; Dr. Prunicki, who
work to create a microchip to more to homeless children with food is documenting how smoke from
accurately and safely diagnose allergies and their families in New air pollution and wildfires affects
allergies has visionary support from York. In Chicago, we are working children at the molecular level; and
the Orsak, Kepner, and Englander with allergy experts to create an Bali Pulendran, PhD, who is making
families. Our clinical trials, bringing educational toolkit with input from discoveries in microbiology and
the best therapies to patients, are the families, who will also test it to immunology that will inform new
made possible by philanthropic gifts make sure it meets their needs. In treatments for allergies and asthma.
from many generous leaders in the California, Barakett scholar Mary The Carell and Gies families are
Stanford community and beyond. Prunicki, MD, PhD, is working with supporting R. Sharon Chinthrajah,
underserved children in Fresno who MD, our clinical director, and
are exposed to air pollution and physician-researcher Sayantani
smoke. We are also continuing our (Tina) Sindher, MD. Dr. Nadeau is
advocacy work with the Center for also grateful to those supporting
Youth Wellness in San Francisco, her professorship, including the
looking for ways to translate the Lainovic, Carell, Li, Sandberg, Orsak,
science on asthma and toxic stress Kepner, Staggs, Bates, Limaye, and
into a plan of action for caregivers Arrillaga families, and many more.
and families, a process we believe
we will be able to apply to other
areas of health care.
22 233
COMMUNITY CONNECTIONS
We continued bringing our Our Center hosted a series of guest Outreach and Support
allergy and asthma community lecturers, including biostatistician
Before, during, and after our trials,
Henry T. Bahnson, MPH, from the
together in the following ways we continue to offer our patients
Benaroya Research Institute in
in 2018: a wide range of support services.
Seattle, a leader in developing
These include: a patient registry to
Community Connections
statistical analysis plans to identify
Community Events move patients into trials as soon
biomarkers for allergies, and Antoine
as possible; the services of a child
2018 Summer Scamper: Our Center Deschildre, MD, a French allergist who
and family therapist in our clinic; a
community, including 7-year-old spoke about France’s experience with
peer support team of trial graduate
Patient Hero Aaron, participated in omalizumab in treating asthma.
families; and graduate webinars
Our Center family stays connected in many this annual 5K, 10K, and kids’ fun run
benefiting Lucile Packard Children’s At our second annual State of the with our clinical staff.
Center community forum in April,
ways, including gala events, educational Hospital Stanford and children’s
health. The event raised more than Dr. Nadeau and our Center staff gave
Expanding access to care: As we
grow, making sure all children have
talks, and perhaps the most fun run in the $3 million. in-depth presentations on allergy,
asthma, and related gastrointestinal
access to the best care and education
for allergies and asthma is becoming
Bay Area—Summer Scamper. Day on the Bay: At the 2018 Day on
the Bay in Santa Clara County, CA, our
disorders, and answered questions
from the audience of patients,
a larger part of our Center’s work.
We are excited about new programs
Center hosted a community booth families, and clinicians. Also in April,
we started in 2018 in San Francisco,
and offered epinephrine auto-injector Dr. Nadeau spoke at TEDx Palo Alto
Chicago, and New York that we plan
training, asthma peak flow testing, on food allergy prevention.
to build on in the future.
and education on asthma and food
Substantial FARE and health of people with food the first person desensitized to Our Center’s team took part in
allergies. More than 10,000 people
allergies, and provide them hope five allergens at once through a leading and speaking at the Keeping All Informed
Leaders in our Center’s philanthropic attended this community event.
through the promise of new trial at our Center. Global Climate Action Summit in Through our e-newsletter, we
community from around the country
treatment. Dr. Nadeau serves as San Francisco in September. The continued to educate those in our
came together in New York City to Talks and Presentations
celebrate and contribute at the FARE’s chief innovation officer. “The clinical trial has so summit brought together thousands community and beyond about our
We started the year by gathering our of leaders from nations, businesses, advancements in allergy and asthma
21st Annual Food Allergy Ball, much more meaning than just scientific community at the inaugural and nongovernmental organizations
The evening honored Kim Yates research and our clinical trials. To learn
sponsored by Food Allergy Research Gordon Research Conference on
(Grosso), a longtime member of my own safety,” 15-year-old to address the threat of climate about our work in 2019, sign up for the
& Education (FARE). As one of FARE’s Food Allergy in Ventura, CA. The change. (Read more about our work
our Center community, for her Tessa told FARE. “I’ve been newsletter at our Center website,
Centers of Excellence, our Center conference provided an informal at the summit in the Global Vision med.stanford.edu/allergyandasthma
seeks to collaborate closely, linking leadership and advocacy on behalf able to connect with people forum for researchers to present section of this update, page 39.) (click on News & Events). Or email
arms on everything from research to of families seeking life-changing inspiring findings and spur further
who understand me, and us at snpcenterallergy.inquiry@
education in support of our common therapies for food allergy. In 2012, innovation in predicting, preventing, stanford.edu.
goal to improve the quality of life Kim’s daughter, Tessa, became I understand them.” and curing food allergies.
24 254
CLINICAL IMPACT
Clinical Impact Sayantani (Tina)
Sindher, MD
Your generous support gives patients in Clinical Assistant Professor
R. Sharon
our clinical trials access to cutting-edge Chinthrajah, MD It’s really nice to see the patients change from the beginning to the
treatments as we work to make the best Clinical Associate Professor end of the studies. At the end, they’re so much bigger and healthier.
My favorite part of the job is the peanut parties we have at the
and safest therapies available to all. and Medical Director
of the Clinical Translational
end of some peanut trials. The patient will eat real peanuts and
the staff joins them. It’s such a celebratory moment—people take
Research Unit videos to share with their friends and families. It’s very moving to
see these families who have gone through life avoiding social
activities and being very scared of accidental ingestions to have
The best part of my job is seeing such a sense of relief.
the patients as they embark
on the journey of a clinical
trial at our Center—they are
so enthusiastic and grateful
to be embraced by our team.
They constantly comment on
how much they learn from us,
even after years of living with
their allergies. And we learn
from them—they inspire us to
find better therapies. Our trials
give them an opportunity to Andres Alvarez Pinzon,
participate in groundbreaking
treatments and to be part of the
MD, PhD, MHA
legacy of allergy research. Director of Regulatory Affairs and Translational Medicine
This is a great time to be in food
allergy research. There is still so My role is to make sure we follow all national and international
much more work to be done, and regulatory affairs guidelines and ensure that we obtain clean data
there is still a lot to learn. We’re outcomes and use best research practices in translational medicine.
just beginning to make therapies This has a direct impact on patient safety—our number one
safer and more effective. There priority. For all of us who work in clinical studies and behind the
are so many other discoveries scenes, we know that we play a key role in improving the quality
to be made. I love being part of of life for our patients. That’s the gift we get from this work. We
that future. make sure the new generations of clinicians have the opportunity to
investigate new drugs and successfully treat conditions related to
R. Sharon Chinthrajah, MD, medical director of clinical research, with a patient (above); Zachary Teixeira, asthma, allergies, and immunology.
RN, MS, and Lisa Lee, RN, MSN, clinical nurse practitioners (top right); Anny Uyehara, NP, research nurse
practitioner, with a patient (center right); and Dr. Nadeau in the clinic (bottom right).
26 27You can also read
