A European Champions League for Research

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European Research Council

A European
Champions
League
for Research

ERC Starting Grants:                                                  ing or moving to work in Europe – the sole criterion for selection
First Swiss Success Stories			                                        is scientific excellence.

The European Research Council (ERC) is the first pan-European         In the first ERC Starting Grant call in 2007 around 300 grants
funding agency for frontier research. It is implemented through       were awarded to promising top scientists in Europe, out of 9,000
the European Union’s Seventh Framework Programme for Re-              proposals. 15 of these grantees are performing their research in
search and Technological Development (FP7), in which Switzer-         Switzerland, including one researcher at CERN, Geneva. Switzer-
land is fully involved as an associated country. It supports indi-    land was thus one of the most successful host countries for top
vidual investigators in all disciplines and fosters excellent basic   researchers : it ranked 2nd in terms of number of grantees per
research at the frontiers of knowledge.                               inhabitants, and 3rd in terms of number of grantees relative to
                                                                      the researcher population.
The ERC Starting Independent Researcher Grant supports start-
ing researchers embarking on an independent career and estab-         The Swiss National Science Foundation, the largest research
lishing or consolidating their own research team. A call for Start-   funding organisation in Switzerland, and Euresearch, the Swiss
ing Independent Researcher Grants is issued every summer.             information network for European Research, would like to con-
The ERC Advanced Investigator Grant supports established top          gratulate the grantees on this great success.
researchers at all career stages. A call for Advanced Investigator
Grants is issued every autumn. Both types of grants are awarded       Who are the grantees working in Switzerland ? What is their re-
through open competition to projects headed by starting or es-        search about ? Let them introduce themselves and guide you to
tablished researchers, irrespective of their origins, who are work-   the frontiers of knowledge !
>
Growth
Control
by the TOR
Signalling
Network
                                                         >             Coherence
                                                                       of Spins in
                                                                       Semiconductor
                                                                       Nanostructures

                                                                       Dominik Zumbühl :
                                                                       “Quantum mechanics is the
                                                                       overarching theory of our world.
Robbie Loewith :                                                       A century after its discovery,
“Our ultimate goal is to under-                                        the time is ripe to try to harness
stand how cell, organ and                                              quantum physics for performing
organism growth is regulated.”                                         computations.”

Why do cancer cells grow uncontrollably while normal,                  How can we use individual electron spins in nanostruc-
untransformed cells remain quiescent ?                                 tures for quantum computation ?

Short Project Summary                                                  Short Project Summary

We now know that the Target Of Rapamycin (TOR) kinases lie             Macroscopic control of quantum states is a major theme in much
at the heart of these fascinating questions. TORs reside in two        of modern physics because quantum coherence enables study of
distinct multi-protein complexes : TOR Complex 1 (TORC1), and          fundamental physics and has promising applications for quantum
TORC2. These two complexes are conserved among eukaryotes              information processing. The potential significance of quantum
and function in signalling pathways that regulate different as-        computing is now recognized well beyond the physics community.
pects of cell growth. By exploiting the facile genetics of the model   For electron spins in GaAs quantum dots, it has become clear
eukaryote Saccharomyces cerevisiae, my lab aims to flesh out           that decoherence caused by interactions with the host nuclear
details of the TOR signalling network with the ultimate goal of        spins is a major challenge. We will investigate and aim to reduce
understanding how cell, organ and organism growth is regulated.        nuclear spin induced decoherence. Further, the exciting combina-
Additionally, given the conservation of the TOR complexes and          tion of interacting electron and nuclear spin physics gives ample
their clinical importance, especially in oncology, we will also em-    incentive to strive for sub-Millikelvin temperatures in nanostruc-
ploy an innovative high throughput screen to identify novel drug-      tures. We propose to build a novel refrigerator aiming to reach
like compounds that inhibit yeast and mammalian TORC1 and              unprecedented low temperatures in semiconductor nanostruc-
TORC2.                                                                 tures. This interdisciplinary project combines Microkelvin with
                                                                       nanophysics and could be the beginning of a new era of coherent
                                                                       spin physics with unprecedented quantum control.

Information on the                 Information                         Information on the                   Information
Principal Investigator (PI)        on the ERC Project                  Principal Investigator (PI)          on the ERC Project

Name                               Title of Project                    Name                                 Title of Project

Prof. Dr. Robbie Loewith           Growth control by                   Prof. Dr. Dominik Zumbühl            Coherence of Spins
                                   the TOR signalling                                                       in Semiconductor
Date of Birth                      network                             Date of Birth                        Nanostructures
20 July 1972                                                           15 January 1974
                                   Acronym                                                                  Acronym
Nationality                        TOR signalling                      Nationality                          COSPSENA
Canadian                                                               Swiss
                                   Budget                                                                   Budget
Host Institution                   965,500 €                           Host Institution                     1,377,000 €
University of Geneva,                                                  University of Basel,
Department                         Duration of Project                 Department of Physics,               Duration of Project

of Molecular Biology,              5 years                             http ://physik.unibas.ch             5 years
www.molbio.unige.ch

2 | Success Stories of ERC Grantees | June 2008
>
Plasticity
of the
Empathic
Brain
                                                          >             The Genetic
                                                                        Basis
                                                                        of Animal
                                                                        Diversity

Tania Singer :
“In today’s world,                                                      Walter Salzburger :
acquiring the capacity                                                  “150 years after Charles
to effectively enhance                                                  Darwin it is high time that we
empathy and prosocial                                                   understood the processes
behaviour is of the                                                     that lead to the emergence
utmost importance.”                                                     of new species.”

What impact does empathy training have on the behav-                    What are the external factors that promote the evolu-
iour and the cortex of individuals ?                                    tion of new species ?

Short Project Summary                                                   Short Project Summary

Despite neuroscientists’ advances in plasticity and empathy re-         The identification of the processes that lead to the emergence of
search, little is known about cortical and behavioural plasticity in    new species remains a fundamental question to biology. Despite
emotional understanding and empathy. In this project we will in-        recent advances in evolutionary and developmental biology, the
vestigate the malleability of empathy via training. Studies 1-3 will    molecular mechanisms underlying diversification, adaptation and
look at differences in the brains of individuals scoring high versus    evolutionary innovation remain largely unknown. The exception-
low on empathy (psychopaths, alexithymics, therapists). In study        ally diverse species of cichlid fishes in the East African Great
4, participants will learn to self-regulate brain activity through      Lakes are excellent model systems for studying the genetic basis
immediate feedback from emotion-related brain areas while prac-         of biodiversity. East Africa’s endemic cichlid species differ greatly
tising certain mental techniques. In Study 5, healthy individuals       in ecologically relevant, hence naturally selected, characteristics
will receive extensive training in empathy-enhancing techniques.        such as mouth morphology, but also in sexually selected traits
We will measure training-related changes in brain structure and         such as coloration. In the framework of my ERC Starting Grant
functioning, in hormone levels, and in prosocial and economic           I will study the genetic basis of certain characteristics that ap-
behaviour. This project should have implications for the devel-         pear to be responsible for the evolutionary success of the cichlid
opment of effective training programmes for schools, economic           fishes, with particular emphasis on features that evolved in paral-
and political organizations and for the treatment of patients with      lel in independent cichlid radiations.
marked social deficits.

Information on the                 Information                          Information on the                 Information
Principal Investigator (PI)        on the ERC Project                   Principal Investigator (PI)        on the ERC Project

Name                               Title of Project                     Name                               Title of Project

Prof. Dr. Tania Singer             Plasticity of the empathic brain :   Prof. Dr. Walter Salzburger        The interaction and the genetic
                                   Structural and functional MRI                                           basis of naturally versus sexually
Date of Birth                      studies on the effect of empathy     Date of Birth                      selected traits in the adaptive
8 December 1969                    training on the human brain and      1 January 1975                     radiations of cichlid fishes
                                   prosocial behaviour
Nationality                                                             Nationality                        Acronym
                                   Acronym                                                                 INTERGENADAPT
German and French                                                       Austrian
                                   EMPATHICBRAIN
Host Institution                                                        Host Institution                   Budget
                                   Budget                                                                  750,000 €
University of Zurich,                                                   University of Basel,
Centre for the Study               1,500,000 €                          Zoological Institute,
of Social and Neural Systems,                                           www.evolution.unibas.ch            Duration of Project

www.socialbehavior.uzh.ch          Duration of Project                                                     5 years
                                   5 years

3 | Success Stories of ERC Grantees | June 2008
>
The Role
of Lymphatic
Vessels in
Dendritic Cell
Homing and
                                                           >          Adipocyte
                                                                      Differentiation
                                                                      and Metabolic
                                                                      Functions in
                                                                      Obesity and
Maturation                                                            Type 2 Diabetes

                                                                      Christian Wolfrum :
Melody Swartz:                                                        “Obesity and metabolic disorders
“Elucidating the initial steps                                        are real scourges of the
in adaptive immunity is ultimately                                    21st century and are increasingly
important for developing                                              becoming the focus of public
immunotherapeutic strategies.”                                        attention.”

How do lymphatic vessels actively regulate the adap-                  What are the molecular mechanisms of adipogen-
tive immune response ?                                                esis linked to the development of the metabolic syn-
                                                                      drome ?
Short Project Summary

Dendritic cell (DC) homing from the periphery to lymph nodes is a     Short Project Summary
critical first event in the immune response, yet the mechanisms       Obesity-associated disorders such as type 2 diabetes and cardio-
of DC migration towards, and entry into, lymphatics are still poor-   vascular disorders, referred to as the “metabolic syndrome”, are
ly understood ; this severely limits new therapeutic strategies for   prevalent traits of industrialized societies. The project aims to
immunomodulation. We propose a battery of physiological, cell-        facilitate understanding of the molecular mechanisms underlying
biological, molecular, and computational studies to determine         altered adipocyte differentiation and maturation in these meta-
both the mechanisms of DC homing to lymphatic vessels and             bolic diseases. To achieve this goal, we will establish novel meth-
how DCs modulate lymphatic function. We approach this from the        ods to isolate pure primary preadipocytes. This will include a new
perspectives of both the DC and the lymphatic vessel. Regarding       animal model that will enable us to monitor preadipocytes in vivo
the DC, we will examine how draining flows toward the lymphatic       and track their cellular fate in the context of a complete organ-
alter their migration tactics. Regarding the lymphatic vessel, we     ism. These systems will allow us to study preadipocyte biology
will elucidate how biochemical and biophysical inflammatory sig-      in an in vivo setting. Furthermore, they will help us answer key
nals regulate their function to facilitate DC homing and entry.       questions regarding the development of preadipocytes and ex-
This deeper knowledge of mechanisms of DC-lymphatic cross-            amine signals that induce or inhibit their differentiation. Detailed
talk in a relevant biophysical context will enable our long-term      knowledge of these mechanisms will facilitate the development
goal of rational design for therapeutic immunomodulation.             of novel therapeutic approaches for the treatment of obesity and
                                                                      associated metabolic disorders.

Information on the                   Information                      Information on the                  Information
Principal Investigator (PI)          on the ERC Project               Principal Investigator (PI)         on the ERC Project

Name                                 Title of Project                 Name                                Title of Project

Prof. Dr. Melody Swartz              The role of lymphatic            Prof. Dr. Christian Wolfrum         Adipocyte differentiation and
                                     vessels in dendritic cell                                            metabolic functions in obesity
Date of Birth                        homing and maturation            Date of Birth                       and type 2 diabetes
26 April 1969                                                         17 July 1972
                                     Acronym                                                              Acronym
Nationality                          DC-LYMPH                         Nationality                         AdipoDif
American                                                              German
                                     Budget                                                               Budget
Host Institution                     1,731,200 €                      Host Institution                    1,700,000 €
Ecole Polytechnique                                                   ETH Zurich,
Fédérale de Lausanne (EPFL),         Duration of Project              Institute of Bioengineering,        Duration of Project

Institute of Bioengineering,         5 years                          www.imsb.ethz.ch                    5 years
http ://ibi.epfl.ch

4 | Success Stories of ERC Grantees | June 2008
>
Epigenetic
Determinants
of the Genome
that Govern
Cellular
                                                          >            Quality Control
                                                                       of Gene Expression :
                                                                       Mechanisms for
                                                                       Recognition
                                                                       and Elimination of
Plasticity                                                             Nonsense mRNA

Dirk Schübeler :                                                       Oliver Mühlemann :
“Stem cells have the fascinat-                                         “A key to understanding life is to
ing ability to differentiate into                                      comprehend how cells transform
any cell type. We will use func-                                       their genetic information into function
tional genomics approaches to                                          or structure, and how mistakes in
understand how this process                                            this process are recognized and
is controlled.”                                                        prevented.”

What is the contribution of epigenetic gene regulation                 How can cells recognize faulty mRNAs and prevent
to cellular identity ?                                                 their translation into dangerous, truncated proteins ?

Short Project Summary                                                  Short Project Summary

How does the cell organize the genome to activate the right gene       Analogous to quality control checks along the assembly line in in-
when needed and to keep it silent at other times ? In the ERC          dustrial manufacturing processes, cells possess multiple quality
project we investigate how the epigenome changes when pluri-           control systems that ensure accurate expression of the genetic
potent stem cells differentiate into cells with defined functions,     information. One of these surveillance mechanisms, called “non-
for example neurons. We will focus on DNA methylation and its          sense-mediated mRNA decay” (NMD), recognizes and degrades
interplay with several histone modifications as a way to achieve       mRNAs in which the information for the encoded protein is trun-
stable gene silencing. By applying new high-throughout methods         cated. By eliminating these defective mRNAs, NMD substantially
we will create global profiles to gain insights into targeting prin-   reduces the synthesis of potentially deleterious proteins in cells.
ciples and generate statistical, predictive models of regulation.      Given that 30% of all known disease-causing mutations in hu-
Mechanistic models will then be derived and tested by geneti-          mans lead to such defective mRNAs, NMD serves as an impor-
cally interfering with regulatory pathways and by dissecting DNA       tant modulator of the clinical manifestations of genetic diseases.
sequence components involved in specifying targets. These ex-          However, the mechanism of NMD is still unknown. One main goal
periments aim to unravel the crosstalk between epigenetic regu-        of our research is to understand at the molecular level how pre-
lation and cell plasticity and to incorporate epigenetic regulation    mature termination codons are recognized and distinguished
into current transcriptional regulatory models.                        from correct termination codons, and how this recognition of
                                                                       nonsense mRNAs subsequently triggers their rapid degradation.

Information on the                  Information                        Information on the                        Information
Principal Investigator (PI)         on the ERC Project                 Principal Investigator (PI)               on the ERC Project

Name                                Title of Project                   Name                                      Title of Project

Dr. Dirk Schübeler                  Epigenetic determinants            Dr. Oliver Mühlemann                      Quality control of gene
                                    of the genome that govern                                                    expression : mechanisms
Date of Birth                       cellular plasticity                Date of Birth                             for recognition and elimination
8 May 1969                                                             18 June 1967                              of nonsense mRNA
                                    Acronym
Nationality                         EpiGePlas                          Nationality                               Acronym

German                                                                 Swiss                                     mRNA quality
                                    Budget
Host Institution                    1,085,000 €                        Host Institution                          Budget

Friedrich Miescher Institute                                           University of Berne,                      1,300,000 €
for Biomedical Research,            Duration of Project                Institute of Cell Biology,
Basel,                              5 years                            www.izb.unibe.ch                          Duration of Project

www.fmi.ch                                                                                                       5 years

5 | Success Stories of ERC Grantees | June 2008
>
Probing the
Relevance
of Carbene
Binding Motifs
in Enzyme
                                                            >         Plant Endo-
                                                                      membrane
                                                                      Trafficking in
                                                                      Physiology
                                                                      and Develop-
Reactivity                                                            ment

                                                                      Niko Geldner :
                                                                      “Plants cover the
                                                                      surface of this planet
                                                                      and provide for our
Martin Albrecht :                                                     everyday needs. We
“Is there anything more fascinating                                   need to understand how
than improving our understanding                                      they manage to adapt
of the pivotal processes of the                                       and strive in diverse
machinery of life ?”                                                  environments.”

Did we overlook relevant binding modes and reactivity                 How are the ordered, subcellular structures of the root
patterns in metalloenzyme chemistry ?                                 barrier put into place in plants ?

Short Project Summary                                                 Short Project Summary

In metalloenyzmes, amino acids are generally considered to bind       In the ERC project I will analyse the Arabidopsis root endodermis
to the metal centre via their heteroatoms, mostly nitrogen or sul-    as an example of a plant polar epithelium. Epithelia are a fun-
fur. Under certain conditions however, a carbon-type bonding may      damental feature of multi-cellular organisms, representing the
be favoured. This possibility has been completely overlooked up       highly selective barriers and interfaces between the organism
to now. This is remarkable, since such a bonding mode affects         and its outside environment. The root endodermis is a tissue
the activity of the metal centre dramatically and may provide a ra-   common to all higher plants and is of central importance for plant
tionale for the mode of action of metalloenzymes that are still not   nutrition. Its function has been known for almost a century, yet
fully understood. Obviously, any evidence for carbon coordination     we do not understand how its molecular structures are set up
in metalloenzymes will therefore induce a paradigm shift in clas-     and maintained. While the endodermis has not previously been
sical peptide chemistry. Moreover, this unprecedented bonding         viewed as an epithelium, it does display all its defining features
mode will provide access to unique and hitherto unknown reactiv-      and therefore provides us with a unique opportunity to study a
ity patterns for artificial enzyme mimics. A multifaceted approach    parallel and independent path of nature towards multi-cellularity.
will be pursued for identifying such bonding in enzymes, includ-      Moreover, understanding the structure and function of the endo-
ing site-directed mutagenesis, screening of classes of native en-     dermis will contribute to our knowledge of how plant roots inter-
zymes and chemical synthesis of active site models.                   act with their soil environment and how they are able to adapt to
                                                                      various biotic and abiotic stresses.

Information on the                    Information                     Information on the                Information
Principal Investigator (PI)           on the ERC Project              Principal Investigator (PI)       on the ERC Project

Name                                  Title of Project                Name                              Title of Project

Prof. Dr. Martin Albrecht             Probing the relevance           Prof. Dr. Niko Geldner            Plant endomembrane
                                      of carbene binding motifs                                         trafficking in physiology
Date of Birth                         in enzyme reactivity            Date of Birth                     and development
12 December 1971                                                      29 May 1972
                                      Acronym                                                           Acronym
Nationality                           CARBENZYMES                     Nationality                       Plant-Memb-Traf
Swiss                                                                 German
                                      Budget                                                            Budget
Host Institution                      1,250,000 €                     Host Institution                  1,200,000 €
University of Fribourg,                                               University of Lausanne,
Department of Chemistry,              Duration of Project             Department of Plant Molecular     Duration of Project

www.chem.unifr.ch                     5 years                         Biology,                          5 years
                                                                      www.unil.ch/dbmv

6 | Success Stories of ERC Grantees | June 2008
>
4D Spatio-
Temporal
Modelling of
Real-World
Events from
                                                         >           Olfactory
                                                                     Perception in
                                                                     Drosophila

Video Streams

Marc Pollefeys :
“To understand complex
visual events, it is impor-                                          Richard Benton :
tant to be able to combine                                           “From mosquitoes to man,
multiple videos into a                                               smell is a highly evocative but
single representation.”                                              deeply mysterious sense.”

How can we recreate virtual representations of events                How do genes and circuits encode smell in the brain ?
from videos ?
                                                                     Short Project Summary
Short Project Summary                                                The overall goal of our research is to understand how sensory
Today video cameras can be found everywhere, from mobile             information in the environment is detected and processed in the
phones to surveillance systems. Often the same event is record-      brain to evoke an appropriate behavioural response. Our proj-
ed from many different viewpoints. The goal of my ERC project        ect focuses on the olfactory system of the fruit fly, Drosophila
is to develop new methods to integrate all these separate views      melanogaster, a model genetic organism that displays a sophis-
into an integrated spatio-temporal model. This model will include    ticated repertoire of odour-driven behaviours under the control of
the shape and motion of all objects in the scene as well as their    neural circuits with similar anatomical and functional properties
appearance. It can be used to relive the event from an arbitrary     to those of mammals but with significantly reduced complexity.
viewpoint or to analyse the event. The video data could origi-       We will take a multidisciplinary approach to this problem, com-
nate from cellphones or camcorders which happened to record          bining bioinformatics, genetics, molecular cell biology, neuronal
an extemporaneous event or be captured by a smart camera             physiology and behavioural analysis. We aim to gain insights into
network set up to track specific events. It is expected that this    a fundamental problem of neuroscience – how genes and circuits
work will have applications in many different areas, ranging from    control behaviour – and the evolutionary mechanisms operating
surveillance, computer games and entertainment to human mo-          in animal nervous systems. Our work also has potential direct
tion analysis and medicine.                                          application in the development of novel strategies to control the
                                                                     chemosensory-driven behaviours of pest insects.

Information on the                 Information                       Information on the                Information
Principal Investigator (PI)        on the ERC Project                Principal Investigator (PI)       on the ERC Project

Name                               Title of Project                  Name                              Title of Project

Prof. Dr. Marc Pollefeys           4D spatio-temporal modelling      Prof. Dr. Richard Benton          Olfactory perception
                                   of real-world events from video                                     in Drosophila
Date of Birth                      streams                           Date of Birth

1 May 1971                                                           27 September 1977                 Acronym
                                   Acronym                                                             OlfactoryiGluRs
Nationality                        4DVideo                           Nationality

Belgian                                                              British                           Budget
                                   Budget                                                              1,500,000 €
Host Institution                   1,750,000 €                       Host Institution

ETH Zurich,                                                          University of Lausanne,           Duration of Project

Institute of Computational         Duration of Project               Center for Integrative            5 years
Science,                           5 years                           Genomics,
www.icos.ethz.ch                                                     www.unil.ch/cig

7 | Success Stories of ERC Grantees | June 2008
>
Cosmology
at the CERN
Large Hadron
Collider
                                                                          >                 Towards Protein
                                                                                            Folding in the
                                                                                            Cell with Single
                                                                                            Molecule
                                                                                            Spectroscopy

                                                                                             Ben Schuler :
                                                                                             “Protein misfolding
Géraldine Servant :                                                                          diseases such
“The LHC will take                                                                           as Morbus Alzheimer
us to a new energy                                                                           pose an escalating
frontier that will allow                                                                     problem for our aging
us to learn about new                                                                        societies. We need
fundamental laws of                                                                          to understand how
physics and change                                                                           the cellular machinery
our views about the                                                                          controls the responsible
early universe.”                                                                             processes.”

What are the deep connections between the funda-                                             What are the dynamic properties of protein molecules,
mental laws of elementary particle physics and the                                           and how do they find their folded structure in a cell ?
properties of our universe today ?
                                                                                             Short Project Summary
Short Project Summary                                                                        Proteins are the most versatile group of biological macromole-
The Large Hadron Collider (LHC), a 7 + 7 TeV proton-proton col-                              cules and form the basis of essentially all functional processes
lider nearing completion at the European Laboratory for Particle                             in living organisms. Following their synthesis as linear chains of
Physics (CERN) in Geneva, will take experiments into a new ener-                             amino acids, they undergo one of the most remarkable self-orga-
gy domain beyond the standard model of strong and electroweak                                nization processes of life, spontaneously rearranging to produce
interactions. As the LHC will unveil the mysteries of electroweak                            the well-defined three-dimensional structure necessary to carry
symmetry breaking, this will also have far-reaching implications                             out their function. Whereas this folding process is autonomous
for cosmology. The aim of this project is to establish what we can                           at low protein concentrations, cells had to evolve a sophisticated
learn from discoveries at the LHC about the early universe. This                             molecular machinery to avoid misfolding and aggregation of fold-
concerns in particular the fundamental question of the nature of                             ing proteins in the crowded environment of the cell. The goal of
the dark matter. Another key topic is the mechanism responsible                              this project is to understand how the mechanisms of protein fold-
for the matter-antimatter asymmetry of the universe, which could                             ing are changed by the central components of this machinery, the
have major implications for gravity wave physics. One goal of this                           so-called molecular chaperones. In a multi-disciplinary project we
project will be to explore thoroughly how the planned gravity wave                           use single molecule fluorescence spectroscopy to address this
detector and space interferometer LISA could complement the                                  question.
information provided by the LHC.

Information on the                           Information                                     Information on the                 Information
Principal Investigator (PI)                  on the ERC Project                              Principal Investigator (PI)        on the ERC Project

Name                                         Title of Project                                Name                               Title of Project

Dr. Géraldine Servant                        Cosmology at the CERN                           Prof. Dr. Ben Schuler              Towards protein folding
                                             Large Hadron Collider                                                              in the cell with single molecule
Date of Birth                                                                                Date of Birth                      spectroscopy
14 May 1974                                  Acronym                                         13 April 1971
                                             Cosmo@LHC                                                                          Acronym
Nationality                                                                                  Nationality                        SingleMolFolding
French                                       Budget                                          Austrian
                                             800,000 €                                                                          Budget
Host Institution                                                                             Host Institution                   1,350,000 €
CERN, European Organization                  Duration of Project                             University of Zurich,
for Nuclear Research,                        5 years                                         Department of Biochemistry,        Duration of Project

Department of Physics,                                                                       www.bioc.uzh.ch                    5 years
http ://cern.ch/ph-dep-th

Missing from this brochure : Prof. Dr. Karl Gademann, EPFL
Editorial staff : Dr. Katja Wirth Bürgel . Euresearch, Danièle Rod Wiesner . SNSF   Design : Agence Symbol, Granges-Paccot   Information : katja.wirth@euresearch.ch
Implementation : Bonhage Gagnebin & Partner, Berne                                  Print : Gerber Druck AG, Steffisburg     www.euresearch.ch/erc, http://erc.europa.eu
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