Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)

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Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Anxiety Disorders During The COVID-
            19 Pandemic

                                   Webmd

         Alyse Folino Ley D.O., FACN
       Child and Adolescent Psychiatry
       MSU Department of Psychiatry
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
• December 2019-cluster of cases
SARs CoV-2     Hubei China
             • January 13, 2020-first case
               outside China
             • January 14, 2020-41 confirmed
               cases (WHO)
             • February 2, 2020 NY Times-
               “Medical workers transporting a
               coronavirus patient into an
               isolation ward in Fuyang, China,
               on Saturday. Experts fear a
               coronavirus pandemic, but its
               severity is uncertain.”-Donald G.
               McNeil Jr.
                    Picture-Chinatopix, via Associated Press
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
SARs CoV-2

CNN.com      Burnett County Sentinel
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Fear and Uncertainty During
COVID-19
• 1/27/21               •   Illness
• 100million infected   •   Isolation
  worldwide             •   Death
• 2 million have died   •   Economic
  worldwide
                        •   Academic
• Jan 2021 “deadliest
  coronavirus month”    •   Domestic Violence
  79,000 (CNN.com)      •   Child Abuse
• US-                   •   Elder Abuse
   • 25,152,433 cases
   • 419,827 deaths
    (COVID.CDC.gov)
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Fear                    Anxiety                Worry
The fight or flight     A feeling of being     The cognitive
response enabling       out of control,        component of
reaction to clear and   focused on future      anxiety
present danger          potentially negative
                        events-out of
                        proportion to the
                        context of life real
                        situation that
                        impairs
                        functioning
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Normal vs. Pathologic Anxiety
                                     • Anxiety can be adaptive
                                        • Signals imminent danger
                                        • Cues into important stimuli
                                        • Modifies Behavior
                                           • Social distance, wear mask, wash
                                             hands
                                     • Abnormal anxiety
                                        • Persistent, excessive, coupled
                                          with no objective threat of harm,
                                          or occurring at inappropriate
                                          times leading to ineffective or
Tippi Hedren with daughter Melanie        self-defeating behaviors
Griffith and their pet lion -1971
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Anxiety in Vulnerable Populations
• Elderly
• Children and Adolescents
• Those with underlining psychiatric conditions
• Homeless
• Racial and Ethnic Minorities
• Health Care Workers
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Covid-19 and Underlying Mental
Illness
• COVID-19 may worsen underlying condition
   • Those with severe chronic conditions most at risk
• Disruption of mental health services
   • Psychiatric
   • Therapy
   • Case management
• Access to medicine
• Social isolation
• Costa et al (2020)
   • 60% of those who had a mental illness felt less connected
     since start of pandemic
   • Most concerned about worsening of their condition and
     running out of medication
Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
Substance Use Disorders and COVID-
19
• Chronic stress may trigger relapse
• Acute withdrawal due to disruption of markets
   • Benzos and alcohol-maybe fatal
         • Could lead to ingestion of toxic ethanol containing products
   • Opiates
• Limited access to treatment
   •   Medications
   •   Acute Medical Detox
   •   Therapy
   •   Groups-AA
   •   Rehabilitation services       (Spagnolo 2020)
Children
• Losses
   • Social contacts
   • 55 million children and teenagers cut off from school staff members
   • Extracurricular
• Academic Changes
   • Transitions
       • Virtual, hybrid, in-person
• Isolation
   • Friends
   • Missed Milestones
• CDC –April 2020-October2020
   • Mental health visits
   • Children 5-11 increased 24% (compared to 2019)
   • Children 12-17 increased 31% (compared to 2019)
                                          (Whitney, 2021)
College Students          • Risk for psychiatric disorders
                              • Onset of Depression, Anxiety and
                                 Psychosis
                          • Risk for suicide
                          • Altered school experience
                          • Academic stress
                          • 2020-Graduates
                              • unemployment
                          • United Nations Report
                              • “Unless urgent action is taken,
                                young people are likely to suffer
                                severe and long-lasting impacts
Plante. TulsaWorld 2020         of the pandemic.”
                                               (Menon, 2020)
COVID-19 and Suicide
• Pandemic may exacerbate an existing crisis
   • The rate of suicide for individuals age 10-24 increased by
     57.4% between 2007-2018

• CDC June 2020
• Survey of the impact of COVID-19 on mental health
• ¼ of those age 18-24 seriously considered suicide
  over the last 30 days
• Impulsivity risk factor in those under 24
                                     (O’Connor, 2020)
Return to School?
• Nevada Clark County
• Virtual since March
  2020
• 326,000 students
• March 2020-Jan 2021
• 19 suicides vs.9 (2019)
              CNN.com
Older Adults
• Isolation
   • Abuse
   • Self care
• Fear
   • Unable/unwilling to seek medical care
   • Food restriction
• Purpose and contribution
• Higher rates of depression in older adults who
  experience
   • Anxiety
   • Loneliness
   • Isolation
COVID-19 and the Indigenous
Community
• Navajo Nation –173, 667 members
• Strength comes from cultural connectedness
• Multigenerational family homes, remote areas Utah, Az,
  NM) often no running water
• DM, Obesity, CVD are common
• In Dine’=The big cough
• July 2020-7,320 tribal members diagnosed
• Blamed for the 1993 Hanta Virus outbreak-decreases rates
  of seeking help
• Historical trauma and discrimination increased rates of
  depression, anxiety, ptsd, ACEs, addiction and suicide
   • 70% report experiencing trauma (Levin, 2020)
COVID-19 and the Black Community
• “Racism impacts health outcomes through close
  alignment with socioeconomic status in this country. It
  is a structural entity that operates on institutions and in
  interpersonal dynamics …” Morgan Medlock MD, MPH
• Increased morbidity
• Increased mortality
• Health Disparity
   • Michigan -14% of the population is Black
   • 30% of COVID cases
   • 40% of deaths
                                       (D’Arrigo, 2020)
Med Students, Physicians and
Residents
•   Fear of illness, death
•   Worry of spreading to loved ones
•   Burden of caring for the dying
•   Uncertainty
•   Fatigue
•   Loss of income
•   Lack of support
     • Initial support of health care hero's diminished
     • Non-believers
• Health Care workers in NY (July 2020)
     • 57% reported acute distress
     • 48% reported depressive symptoms
     • 33% reported anxiety (Zilber 2020)
Neuropsychiatric Impact
• To Be Determined….
• Impaired consciousness
• Stroke
• Cognitive disturbance
• Fatigue
• Psychiatric conditions
• Survivors of 2003-2004 Hong Kong SARs Outbreak
  • 369 survivors-40% were diagnosed with a psychiatric
    condition 4 years after (Zilber, 2020)
Post COVID Infection and Psychiatric
Disorders
• Lancet November 2020-
• De-identified data from 69.8 mill patients in 54 health
  care organizations
   • 62,354 diagnosed with COVID Jan 2020-Aug 2020
• Individuals with a psychiatric disorder were 65% more
  likely to be infected with COVID-19
• 1 in 5 COVID-19 patients are diagnosed with anxiety
  or depression within 3 months of testing positive for
  the virus
   • Increased medical attention
   • Stress of pandemic
When Does Anxiety
Become a Psychiatric
    Condition?
Anxiety
• The most common psychiatric disorders in children and adults
• The most prevalent disorders
    • 25% lifetime prevalence
    • 14% point prevalence
• Onset often in childhood
• Children and Adolescents-6-18% depending on age
• Children may not recognize that their anxiety is excessive or unreasonable
    •   Decreased verbal abilities to express internal symptoms
    •   Concrete thought in children under 11
    •   Frequent physical complaints
    •   “stomach ache” “head ache”
    •   Problems with attention, focus and concentration
    •   School refusal
    •   Parental anxiety poses a specific risk for anxiety disorders children (Lawrence
        2019)
Risk Factors
• Family history/genetic predisposition
• Poor family support
• Family discord
• Dysfunctional parenting
• Parent with untreated mental illness
• Poor self-esteem/inadequate self image
• Emotional dysregulation
• Lack of social acceptance
• Substance Abuse
Dimensions of Anxiety
Subjective           Behavioral             Physiologic

Tension              Avoidance              Muscle tension
Apprehension         Impaired speech and    Increased HR
Sense of impending   motor coordination     Dry mouth
doom                 Performance deficits   nausea
Expectations of
inability to cope
Consequences of Anxiety
• Emotional
   • Fear and guilt
• Cognitive
   • Impaired concentration and problem solving
   • Impaired academic and vocational achievement
• Behavioral
   • Avoidance-school, social interaction
   • Self-medicating-substance abuse
• Physiologic
   • Poor self care
   • Lowered immune response
Symptom Variation
• Symptoms manifest
  differently at different
  ages
    • Cognitive
      development
    • Ability for abstract
      thought
    • Social functioning
    • Communication
      skills
Anxiety Disorders
• Generalized Anxiety Disorder
• Specific Phobia
• Social Anxiety Disorder
• Panic Disorder
• Agoraphobia
• Selective Mutism
• Separation Anxiety
GAD
• A. Excessive anxiety and worry
• B. Difficult to control the worry
• C. Anxiety and worry are associated
    • 1. restlessness or keyed up
    • 2. being easily fatigued
    • 3. difficulty concentrating
    • 4. irritability
    • 5. muscle tension
    • 6. sleep disturbance
Social Anxiety Disorder
•   A. Fear or anxiety about one or more social situations in
    which the individual is exposed scrutiny
       • Fear of embarrassment or humiliation
       • * in children must occur in peer settings and not just
         with adults
•   B. Fears that he/she will act in a way or show anxiety
           symptoms that will ne negatively evaluated
           (humiliating or embarrassing)
•   C. Social situation produces anxiety which may
           predispose to a panic attack
       • * in children -expressed as crying, tantrums, freezing or
         shrinking
•   D. Fear out of proportion to actual threat
•   E. Caused distress or impairment
•   F. Situations are avoided
       • * in children this feature may be absent
Specific Phobia
  A. Marked fear about a specific object or
  situation
  • * in children often expressed as crying,
     tantrums, freezing or shrinking
• B. Phobic object or situation provokes immediate
  fear or anxiety
• C. Feared object or situation is avoided or endured
  with intense fear
• D. Causes distress or impairment
Panic Disorder
• A. Recurrent unexpected panic attacks
      • Palpitations, pounding heart, increased HR, sweating,
        trembling or shaking, SOB, feeling of choking, chest pain or
        discomfort, nausea or abdominal distress, feeling dizzy or
        unsteady, derealization, fear of losing control or going crazy,
        fear of dying, paresthesias, chills or hot flashes
   • At least one of the attacks has been followed by
      • Persistent concern
      • Worry about the implications of the attack or its
        consequences
      • Significant change in behavior related to the attacks
Agoraphobia
• A. Marked fear or anxiety about 2 (or more)
   • Public transportation, open spaces, enclosed spaces,
     crowds, outside of the home alone
• B. The person fears or avoids these situations
  because of thoughts that escape might be difficult
  or help might not be available
• C. Situation produces fear or anxiety
• D. Avoidance
Separation Anxiety
• Normal from 12 months-30 months and briefly in
  kindergarten and 1st grade
• Typically begins during school age
• Fear of harm to self or parents
Selective Mutism
• A. Consistent failure to speak is specific social situations-at
  least one month
• B. The disturbance interferes with educational or
  occupational achievement or with social communication
Obsessive Compulsive Disorder
• A. obsessions or compulsions
     • Obsessions
          • Recurrent and persistent
             thoughts, impulses, or images
             that are intrusive and
             inappropriate and that cause
             marked anxiety or distress
     • Compulsions
          • Repetitive behaviors that the
             person feels driven to perform in
             response to an obsession or
             according to rules that must be
             applies rigidly
          • The behaviors or mental acts are
             aimed at preventing or reducing
             distress or preventing some
             dreaded event or situation
Posttraumatic Stress Disorder
• Traumatic event
• Intrusive Symptoms: event re-experienced
• Negative Alterations in Cognition and mood
• Avoidance of stimuli associated with the trauma and
  numbing of general responsiveness
• Increased arousal
Treatment of Anxiety Disorders in
Children and Adolescents
• Therapy is first line
• Cognitive Behavioral Therapy (CBT)
• Specific Targeted Therapies (based in CBT)
   •   PTSD-Trauma Focused CBT
   •   Specific Phobia, -Systematic Desensitization
   •   OCD-Exposure Response Prevention Therapy
   •   Panic-Exposure Therapy
CBT

            Automatic
            Thoughts

Emotional   Behavioral   Somatic
Changes      changes     changes
Core                   Automatic
Belief/Schema               thoughts

                Emotional
                 changes
Dysfunctional                                    Functional
                         Thoughts                               Thoughts
  Behavior
                         Negative       Behavior                 Positive
    Avoid
                        Self-critical   Confront                Balanced
   Give up
                          Biased        Change                 Acknowledge
Inappropriate

             Feelings                               Feelings
             Anxious                                Relaxed
            Depressed                                Calm
              Angry                                  Happy
Cognitions                    Behavior                       Emotions

Thought monitoring-           Activity monitoring-identify   Affective education-
identification of automatic   reinforcers                    distinguish between core
thoughts                                                     beliefs and physical
                                                             symptoms

Identification of cognitive   Goal planning                  Affective monitoring-rating
distortions                                                  scales, rate intensity

Thought evaluation-           Target settings-practice       Affective management-
cognitive restructuring                                      relaxation, anger
                                                             management

Development of new            Graded exposure-response
cognitive skills              prevention

                              Learn new skills-modeling,
                              rehearsal
Response to CBT
• Wolk et al-JAACAP 2015
  • 7-19year follow-up study on adults who completed CBT
    as children
  • Chronic and enduring suicidal ideation is found in people
    who suffered from childhood anxiety that was not
    properly treated.
  • CBT has both short and long term benefits
  • Highlights the importance of early identification and
    evidence based treatments
Recommendations in Children and
Teens
• CBT recommended as first line
• SSRIs in Children and Adolescents
   • Only medications supported by RCT
   • Studies: SAD, GAD, OCD, Soc Phobia
   • Equally efficacious
      • Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram
      • start low dose and titrate toward efficacy
   • No improved efficacy with SNRIs (Venlafaxine)
   • SSRIs are associated with more rapid greater
     improvement than SNRIs (Strawn et al 2018)
Child-Adolescent Anxiety Multimodal
Study (CAMS)
• Walkup et al. N Engl J Med 2008, 359: 2753-2766.
• 488 children, ages 7-17
    • Separation anxiety, GAD, Social phobia
• Study Arms
    •   14 Sessions CBT
    •   Sertraline (up to 200mg/day)
    •   Combination
    •   Placebo
• Anxiety measured at baseline 4,8 and 12 weeks
    • Anxiety Disorders Interview Schedule for DSM-IV child
          • Establish diagnosis
    • Clinical Global Impression-Improvement Scale
          • Clinically meaningful improvement in anxiety
    • Pediatric Anxiety Rating Scale
          • Level of Anxiety 0-30; >13 moderate levels=anxiety disorder
Key Outcomes at 12 Weeks

Walkup JT et al. N Engl J Med 2008;359:2753-2766
Conclusions
• Compared with placebo, the 3 active therapies- CBT,
  Sertraline and combination are effective short term
  treatment of GAD, social phobia and separation anxiety.
   •   Clinical Global Impression-12 weeks
   •   Combo 80.7% (P
Scores on the Pediatric Anxiety Rating Scale
                         during the 12-Week Study

Figure 2. Scores on the Pediatric Anxiety Rating Scale during the 12-Week Study. Scores on the Pediatric
   Anxiety Rating Scale range from 0 to 30, with scores higher than 13 consistent with moderate levels of
    anxiety and a diagnosis of an anxiety disorder. The expected mean score is the mean of the sampling
                                            distribution of the mean. The I bars represent standard errors.
The Pediatric OCD Treatment Study POTS
• A balanced, masked randomized controlled trial:
   • conducted in 3 academic centers in the United States
   • volunteer outpatient sample of 112 patients aged 7 through 17
     years with a primary Diagnostic and Statistical Manual of Mental
     Disorders, Fourth Edition diagnosis of OCD
   • Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score
     of 16 or higher.
   • Recruited between September 1997 and December 2002.
• INTERVENTIONS:
   • Random assignment to receive CBT alone, sertraline alone,
     combined CBT and sertraline, or pill placebo for 12 weeks.
• MAIN OUTCOME MEASURES:
   • Change in CY-BOCS score over 12 weeks as rated by an independent
     evaluator masked to treatment status; rate of clinical remission
     defined as a CY-BOCS score less than or equal to 10.
POTS
• RESULTS:
• Ninety-seven of 112 patients (87%) completed the full 12 weeks of
  treatment.
• Combined treatment also proved superior to CBT alone (P = .008) and to
  sertraline alone (P = .006), which did not differ from each other.
• Clinical remission:
    • combined treatment was 53.6% (95% confidence interval [CI], 36%-70%);
    • CBT alone, 39.3% (95% CI, 24%-58%);
    • sertraline alone, 21.4% (95% CI, 10%-40%);
    • placebo, 3.6% (95% CI, 0%-19%).
    • The remission rate for combined treatment did not differ from that for CBT
      alone (P = .42) but did differ from sertraline alone (P = .03) and from placebo
      (P
Approach to Multiple School
Transition
• Multiple Transitions increase anxiety
• School Refusal
   • Requires prompt attention regardless of the cause; the longer
     the child is out of school, the higher the likelihood of
     treatment resistance
• Treatment: Behavioral
    • Limit setting
    • Eliminate secondary gain
    • Relaxation training
    • Exposure
        • Increasing lengths of time at school or virtual
          learning
        • Rewarding child for graduated success
When to Start Medications
• Prolonged course
• Limited response to therapy alone
• Severely impaired functioning
• Comorbid conditions
Treat Co-morbid Conditions
•   Anxiety disorder
•   OCD
•   Major Depressive Disorder
•   Trauma/PTSD
•   ADHD
•   Substance Use Disorder-cannabis
•   Psychosis
     • Rare 1/10,000
• Bipolar Disorder
     • Rare
Cannabis
• Not helpful in psychiatric conditions
• Amotivational Syndrome
• THC (delta-9-tetrahydrocannabinol) content dramatically increasing
    • 1970s-less than 2%
    • 1990-3.74%
    • 2018-20-25%
    • Oil, wax, shatter, budder- extracts nearly pure THC
• Daily use
    • 0.7% -8th graders
    • 3.4%-10th graders
    • 5.8%-12th graders
• Risk of addiction 10%-equal to alcohol
• Use before age 18 increases the risk of Cannabis Use Disorder by 4-7 times
• Cannabis Use Disorder
    • 1.5% of Americans (NIDA 2018)
Cannabis Use in Adolescents and Risk
• Gobbi et al (2019)
   • Neuroanatomic differences in regions with type 1
     cannabinoid receptors
       • Decreased volume of hippocampus, amygdala, prefrontal cortex
• The younger users of cannabis were at significantly higher risk
  of suicidal behavior
• The younger the onset of use the higher the risk
    • Depression, anxiety, psychosis, academic and vocational
      functioning
    • Quitting cannabis by the end of adolescence did not
      protect people from most of the serious effects
Cannabis
• Induces and exacerbates psychiatric conditions
    • Anxiety
    • Depression
    • Psychosis (induction of schizophrenia, cannabis induced psychosis)
    • Amotivational syndrome
    • Decreased concentration, working memory, processing speed and IQ
    • Paranoia
    • Hallucination
    • Panic
    • Increases risk of violence and aggression
    • Reduced school performance
    • Reduced life satisfaction
    • Impaired driving-10.3% of 12th graders drove after using in the past two weeks
      (NIDA-2018)
Treatment Approach
• Therapy-CBT/IPT
   • Family involvement is essential with children/teens
   • Psychoeducation
      • Instruction on relapse prevention
          • Medication compliance
          • Recognizing symptoms of relapse
          • Avoiding precipitants
             • Sleep deprivation and substance abuse
• School Accommodations
   • Remedial education or tutoring may be necessary
• Medication determination
Starting/Monitoring SSRI
• Review risk factors
    • Family history
    • Past attempts
• Psychoeducation
    • Warning signs
    • Close monitoring
    • Worsening of symptoms
    • Activating symptoms
• Risks, benefits, side effects and alternatives
• Suicide risk assessment
• Access to weapons
SSRIs
• First line medications
• SNRIs can also be used
• Start low dose
   • Limit side effects
   • Limit anxiety
   • Increase compliance
• Titrate toward efficacy while monitoring for side
  effects
• Allow at least 6 weeks to establish efficacy
• Continue 6-12 months once in remission
Medications
• Medications:
• SSRIs are first line
   • Fluoxetine (Prozac): FDA approved for the treatment of
     depression in children (>8) and adolescents (8-18 years)
   • Escitalopram (Lexapro) FDA approved in adolescents
     (12-17 years)--April 2010
   • All SSRI medications (Fluoxetine, Paroxetine, Citalopram,
     Escitalopram, Sertaline and Fluvoxamine)-equal efficacy
   • SNRIs (venlafaxine, desvenlafaxine, duloxetine),
     Buproprion, Mirtazepine-do not improve efficacy but
     may increase SI
   • TCAs not more efficacious than placebo in children
Medications
• Fluvoxamine (Luvox)
    • OCD>8
• Sertraline (Zoloft)
    • OCD 6-17
• Fluoxetine (Prozac), Paroxetine (Paxil)
    • OCD 7-17
• Clomipramine
    • OCD >10
• Imipramine
    • Nocturnal enuresis, depression and chronic pain >6
SSRI Side-effects
•Nausea, diarrhea, constipation,
 increased anxiety with initiation,
 weight loss or gain, somnolence,
 insomnia
•Very little risk with overdose
•Serotonin syndrome
Black Box Warning
• 2004 FDA warning: adolescents-age 24 increased
  suicidal ideation
• Meta-analysis of SSRIs and depression in
  adolescents- 2400 participants
• Increase in suicidal ideation
   • Depressed adolescents
   • 3.8 %(SSRI) vs. 2.1% (controls)
   • No completed suicides in any of the
     studies
Black Box
Ripped from the Headlines
•“FDA Links Drug to Being
 Suicidal”-New York Times-
 September 14, 2004
•“How Paxil Killed Our Son” -New
 York Post-September 19, 2004
Black Box Warning
Unintended Consequences
• Decline in suicide rate from 1990-2004
• 25% decrease SSRI prescription rate in
  2004
• CDC-14% increase in suicide rates 5-19
  year olds in 2004 compared to 2003
Research on BBW
• Some conflicting evidence
   • Increased suicidal behaviors after 2004
      • Meta-analysis-JAMA 2007
      • US Food and Drug Administration-BMJ 2009
   • Decreased suicidal behaviors after 2004
      • Analysis FDA reports-Am J Psychiatry 2003,
        2007
Research On BBW
• FDA advisory associated with reduction in rates of diagnosis
  and treatment with no increase in treatment alternatives Am J
 Psych 2007
• Number of children and adolescents who were prescribed
  antidepressants significantly decreased. Shift in care from
  generalist to psychiatrists Arch Gen Psych 2007
• Children’s depression visits and visits with antidepressant
  declined after advisory Psych Serv 2011
• Suicide rate among adolescents rose in 2004, the year the
  warning went into effect, for the first time in 15 years BMJ 2014
Consensus
• Same increase in SI not found in studies on anxiety
  disorders
• Untreated depression is the most serious risk for
  suicide
• FDA warning was not intended to discourage
  legitimate treatment
• FDA warning was not intended to be a
  contraindication
Anxiety Disorders
• Helpful
  • Cognitive Behavioral Therapy
  • Collaboration with school
      • IEP, 504, behavioral plan, counseling, tutoring,
        accommodations                                 •

  • Psychoeducation for parents and caregivers
  • SSRIs/SNRIs
  • Safety plan
  • Remove all weapons from the home
  • Close monitoring
  • Involvement in positive peer- related activities
Not Recommended
• Alternative “therapy”
   • No evidence base
   • Delays proper treatment of a life-
     threatening condition
      • EEG diagnosis by non-physicians
   • Cause/exacerbation of symptoms
      • Cannabis (THC), Alcohol, illicits
   • Expensive
Outcome
• Early identification and treatment
• Severity of illness
• Co-morbid substance use disorder
• Level of hopelessness
• Family stressors
Resources for Children, Teens and
Families    • AACAP -
              https://www.aacap.org/coronavirus#families
                   • Tips for transition back to school
                   • How to Talk to Your Kids about Coronavirus - New York Times
                   • 5 things to remember when talking to kids about the Coronavirus -
                     Chicago Tribune
                   • Just for Kids: A Comic Exploring the New Coronavirus
                   • Comic: How To Turn Your Home Into A School Without Losing Your
                     Sanity
                   • The Clay Center for Young Healthy Minds - Self-Care for Resilience
                     Resources
                   • A Parent's Guide to COVID-19 - The Rush Cast Podcast
                   • Tips to Keep Children Healthy While School’s Out
                   • How to Explain the Coronavirus Pandemic to Young Children -
                     Newsweek
                   • Tips for Supporting Student Wellness During COVID-19
                   • I Have a Question About Coronavirus: Clear Answers for All Kids
Resources
for HCP
Videos, Podcasts and Webinars
CBT MGH- https://vimeo.com/398929603/0dcf0ba166

Webinar Series HMS: Regulating emotions and building resiliency in the
face of pandemic
Role of anxiety- https://vimeo.com/398662331/748f60ecce
Slowing the brain- https://vimeo.com/398675016/b40bf3a0ba
Charging up and staying connected- https://vimeo.com/400727093/254169fb7e
Exploring thoughts- https://vimeo.com/401092639/094cc41127

How family members and friends can support COVID caregivers –
HMS https://youtu.be/rcaYlDOQsHY

Caring for yourself and others during COVID-19 pandemic: managing
health care worker’s stress – Schwartz center for compassionate care
• https://youtu.be/F4LU-EoAFew
Videos, Podcasts and Webinars
Free 3-session video course on resiliency skills for healthcare
providers
MGH Resiliency and prevention program
https://www.resilienceandprevention.com/healthcare-providers

 Clinical Self Care in the time of COVID- Mc Lean Hospital
(available with Spanish & hindi subtitles)
https://www.mcleanhospital.org/video/dr-blaise-aguirre-offers-
covid-19-coping-tips-health-care-workers
BIPOC (Black, Indigenous and people of color) Self-guided resources
     The Safe Place: Free smartphone app focused on psychoeducation and
    self-care for minority mental health, geared towards the Black
    community

     Liberate: Free meditation app designed specifically for the BIPOC
     community and led by BIPOC teachers

       Racial Trauma Guide: Virtual guide on coping with racial stressors and being an
       ally, developed by the EMPOWER (Engaging Minorities in Prevention Outreach
       Wellness Education & Research) Lab
        https://www.psychology.uga.edu/racial-trauma-guide

   Black Emotional and Mental Health (BEAM) Toolkit & Resources
          https://www.beam.community/tool-kits-education
Resource: COVID Coach
From: U.S. Department of Veterans Affairs Free app to support coping and resilience during the COVID-19
pandemic. Includes tools for tracking mood, managing stress, navigating caregiving, staying healthy and
connected and connecting to further resources as needed
Resource: Mindshift CBT (app)
Free interactive cognitive-behavioral tools to manage anxiety, develop
more effective ways of thinking and take positive action

Resource: Stop, Breathe & Think (app)
Free app to help notice feelings and reactions, practice mindful breathing,
and broaden perspectives via guided meditations
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COVID.CDC.gov
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