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ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
Vol. 20 / No. 5 / May 2021

          FIRST CLASS

  Meet the inaugural
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ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
CONTENTS

   NEWS                                         FEATURES                     PERSPECTIVES

2                                             32                           44
EDITOR’S NOTE                                 TARGETING 20,000 PROTEINS    WINNERS OF THE ‘AHA MOMENTS’
‘Share your aha moments!’                     BY 2035                      ESSAY CONTEST
                                                                           44	Finding a common ancestor
4                                             38                           45	Dreaming of Western blots
MEMBER UPDATE                                 EXPLORING UNDERAPPRECIATED   46 Beauty in brown
                                              MOLECULES AND NEW CITIES     47 Fringe inspiration
8                                                                          47 A life filled with aha moments
IN MEMORIAM                                                                48	The first to know

9                                                                          49	The right experiment
                                                                           49 Prepared mind leads to life-saving
RETROSPECTIVE                                                                 medical advice
Remembering Curtiss, former JLR
associate editor                                                           50 Superhero science
                                                                           51 Not quite out of the box
10                                                                         52
MEMBER NEWS
First class: Meet the inaugural                                            FIVE QUESTIONS
ASBMB fellows                                                              Alanna Mitsopoulos: “I could be happy doing
                                                                           other things”
20
LIPID NEWS
Ceramides’ role in liver disease

16
                                                                   10
JOURNAL NEWS
21	JLR names new junior associate editors
23	Study reveals experimental targets
    for lymphoma research

                                               32                          44
24 Researchers target cell membrane
   for cancer research
25 Parasitic secretions create
   microenvironment for survival
26 From the journals

20                                             38                                                          52
MAY 2021                                                                                                    ASBMB TODAY   1
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
EDITOR’S NOTE
                                                     Vol. 20 / No. 5 / May 2021

   THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY
     FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY

          THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY
                                                                                                     ‘Share your aha moments!’
                    OFFICERS ANDCOUNCIL
            FOR BIOCHEMISTRY           MOLECULAR MEMBERS
                                                      BIOLOGY
               Toni M. Antalis
                                     Suzanne Barbour
                                     Joan Broderick
                                                                                                     By Allison Frick
                        President
                       OFFICERS Charles COUNCIL
                                              CraikMEMBERS

                                                                                                     I
                   Gerald Hart          Squire  J. Booker
                      Gerald   Hart  Matt  Gentry
                   Past President       Victoria
                          President Susanna       J. DeRose
                                               Greer                                                     ’m not a scientist. My back-            Fast-forward to January 2021,
                      Wei Yang          Blake Hill
                 Jennifer  DuBois
                        Secretary
                                     Audrey   Lamb
                                        Audrey Lamb                                                      ground is in broadcast jour-         when ASBMB’s journals made
                           Secretary James  M.M.
                                        James   Ntambi
                                                   Ntambi                                                nalism. When I came to the           the transition to gold open access.
                Joan Conaway         Takita
                                        CeliaFelder  Sumter
                                               A. Shiffer
                  Toni Treasurer
                        M. Antalis
                                     Kelly Ten–Hagen
                                        Takita  Felder Sumter
                                                                                                     American Society for Biochemistry        Papers published in the Journal of
                          Treasurer
                                        Kelly Ten-Hagen                                              and Molecular Biology in 2015,           Biological Chemistry, the Journal
       EX-OFFICIO MEMBERS
          EX-OFFICIO MEMBERS         ASBMB
                                        JoAnnTODAY
                                                Trejo EDITORIAL                                      it was from a local TV station,          of Lipid Research, and Molecular
        Robert    S. Haltiwanger                      ADVISORY BOARD                                 where I covered high school sports       & Cellular Proteomics were going
           Robert    S. Haltiwanger
                   Carla  Koehler                       ASBMB
                                                      Rajini Rao TODAY EDITORIAL
                      Carla Koehler                                                                  online and worked with reporters         to be published immediately and be
   Co-chairs,Co-chairs,
              2020/2021    Annual                       ADVISORY BOARD
                                                      Chair
                        2020 Annual
    Meeting
       MeetingProgram
                 ProgramCommittee
                          Committee                   AnaRajini
                                                           MariaRao
                                                                  Barral                             and producers on related TV ele-         permanently available for everyone
                                                         Chair
                                                      Natasha Brooks
                  Cheryl Bailey
                     Cheryl Bailey                       Floyd  “Ski” Chilton                        ments. Biochemistry and molecular        to read, download, copy, distribute
Chair, Education and Professional                     Kelly  Chacón
              Chair, Education and
         Development Committee
          Professional Development
                                                         Henrik Dohlman
                                                      Beronda Montgomery
                                                                                                     biology were a far cry from Friday       and reuse. In preparation for the
                                                         Peter J. Kennelly
                  DanielCommittee
                           Raben                      BillBeronda
                                                           SullivanMontgomery                        night lights. I was nervous to enter     change, our marketing and com-
      Chair, Meetings Committee
                     Daniel Raben                     Melissa  VaughtRouhi
                                                         A. Maureen                                  a new realm of content, but, more        munications teams were tasked with
                    SoniaCommittee
        Chair, Meetings    Flores                     Binks  Wattenberg
                                                         Melissa  Vaught
          Chair, Minority Affairs                                                                    importantly, I was excited for a new     coming up with a plan to share the
                       Sonia Flores                      Binks W. Wattenberg
                       Committee
             Chair, Minority Affairs                  ASBMB TODAY                                    challenge.                               news.
              Nicole Woitowich
                         Committee                      ASBMB TODAY
                                                      Angela Hopp                                        The thing that I absolutely love        Last fall, Joanna Kotloski, then
    Chair, Science Outreach and                           AngelaEditor
                                                                   Hopp
                   Susannna
     Communication Committee   Greer                  Executive
                                                          Executive Editor
                                                                                                     the most about working in commu-         our digital and content marketing
             Chair, Public Outreach                   ahopp@asbmb.org
               Terri GossCommittee
                           Kinzy                          ahopp@asbmb.org                            nications is hearing people’s stories.   manager; Anand Rao, our publica-
             Chair, Public Affairs                    Comfort Dorn
                                                          Comfort Dorn                               I love learning about how they’ve        tions department’s science com-
               Matthew    S. Gentry
             Advisory Committee                       Managing Editor
                                                          Managing Editor
                                                      cdorn@asbmb.org
               Chair, Public Affairs
                   Ed Eisenstein                          cdorn@asbmb.org                            navigated life. In fact, when I was      municator; and I all hopped on
                Advisory Committee
  Chair, Membership Committee                         Laurel
                                                          JohnOldach
                                                                Arnst                                a kid, I really wanted to grow up        Zoom one afternoon and started
                     Sandra Weller                    Science  Writter
                                                          Science Writer
                  SusanPublications
                 Chair,  Baserga                      loldach@asbmb.org
                                                          jarnst@asbmb.org                           to be an actress. My logic: I’d never    brainstorming. We wanted to come
  Chair, Women in Biochemistry
                         Committee
          and Molecular Biology                       Ed Laurel
                                                           MarklinOldach                             have to choose just one job. I could     up with a fun way to encourage
                  Lila Committee
                       M. Gierasch                    WebScience
                                                            EditorWritter
                Editor-in-chief, JBC                      loldach@asbmb.org
                                                       emarklin@asbmb.org
                                                                                                     try everything if I was an actress.      scientists to share their discoveries in
                  Sandra Weller                           Ed Marklin                                 It turns out performing is not my        ASBMB journals. I love these brain-
                 A. L.Publications
              Chair,   Burlingame                     Allison   Frick
                                                          Web Editor
                       Editor, MCP
                       Committee                      Multimedia    and Social Media
                                                           emarklin@asbmb.org                        forte, but I never lost that passion     storming sessions and admire Joan-
               Nicholas
                 Lila M.O.Gierasch
                            Davidson                  Content   Manager
                                                          Allison  Frick                             for storytelling and learning about      na and Anand for their creativity. As
                Editor-in-chief, JBCJLR
                  Editor-in-chief,                    africk@asbmb.org
                                                          Media Specialist
                                                          africk@asbmb.org
                                                                                                     the human experience.                    we talked about what motivates us
                  A. L.Kerry-Anne
                        BurlingameRye                 Stephen    F. MIller
                        Editor, MCPJLR
                   Editor-in-chief,                       Barbara
                                                      Executive     Gordon
                                                                 Director                                Once I got to the ASBMB and          to connect with organizations and
                                                          Executive Director
                                                      smiller@asbmb.org
           Nicholas O. Davidson                           bgordon@asbmb.org
                                                                                                     began working as a multimedia            remember content, TikTok came
              Editor-in-chief, JLR                                                                   content specialist and sharing           to mind. Then Joanna remembered
                   Kerry-Anne Rye
                 Editor-in-chief, JLR
                                                                                                     articles from ASBMB Today on             one of her favorite commercials
                                                                                                     our social media channels, I started     from Southwest Airlines, and as the
        For
          Forinformation
               informationononadvertising,
                                advertising,contact
                                              contactPharmaceutical
                                                      Pharmaceutical                                 getting to know our members and          ideas kept coming, we landed on the
        Media Inc.
        Media  Inc. at
                    at 212-904-0374
                       212-904-0374 or  or mperlowitz@pminy.com.
                                           mperlowitz@pminy.com.
                                                                                                     the scientific community. I quickly      slogan “Share your aha moments!”
                                                                                                     learned that scientists have fascinat-   That was the beginning; we’d make
                                                                                                     ing stories. From their personal         a TikTok-inspired video with our
                                                                                                     experiences to their research, they      members passing papers to one
                        www.asbmb.org/asbmbtoday
                        www.asbmb.org/asbmbtoday                                                     are inspired to figure out how this      another and a second video with
                                  PRINT
                                   PRINTISSN
                                         ISSN2372-0409
                                              2372-0409                                              world works. I knew I was going to       words of encouragement about the
            Articles
       Articles       published
                published          in ASBMB
                            in ASBMB      TodayToday
                                                  reflectreflect
                                                           solelysolely the authors’
                                                                  the authors’   viewsviews
                                                                                       and not
                                                                                                     hear some amazing stories working        opportunities offered by publishing
       and  not thepositions
       the official  official positions  of the American
                               of the American    Society forSociety  for Biochemistry
                                                                Biochemistry             and
                                                                                and Molecular        here, and I have.                        in an ASBMB journal.
       Molecular
       Biology or Biology    or the institutions
                    the institutions  with whichwith      which the
                                                    the authors    areauthors   are Mentions
                                                                        affiliated. affiliated. of
       Mentions
       products orofservices
                      productsareornot
                                    services are not endorsements.
                                       endorsements.

  22                   ASBMB
                       ASBMB TODAY
                             TODAY                                                                                                                                            MAY 2021
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
ASBMB                                                                                                                                                                                     EDITOR’S NOTE

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                                                                                                                          Ngee Kiat “Jake” Chua encouraged his fellow
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        journals’ associate editors and JBC’s    the winning essays in this issue, start-                                 ASBMB members to share their aha moments.
        early-career reviewers. They showed      ing on page 44. We hope you enjoy
        up and went above and beyond to          them as much as we did.
        bring this to life. I have to thank         When I reflect on my own career,
        Ray Blind, Craig Cameron, George         I realize my first few months at the
        Carman, Courtney Chandler, Ngee          ASBMB were huge for me. Before                                           We’re publishing the winning
        Kiat “Jake” Chua, Michel Geovanni        starting here, I’d taken steps toward
        Santiago–Martínez and Catherine          changing fields. I wasn’t sure com-                                      essays in this issue, starting on
        Goodman for graciously appearing         munications was right for me, but my                                     page 44. We hope you enjoy them
        in these videos. Their performances      experience at the ASBMB reminded
        were outstanding! You can see for        me how much I love storytelling and                                      as much as we did.
        yourself on the ASBMB’s YouTube          multimedia. It was career-changing.
        channel.                                 Working here was my aha moment,
            From there, another element          and to this day, not a month goes by
        of the “Share your aha moments!”         when I’m not reminded I’m in the
        project came to life, and for this,      right place. This month, that’s thanks
        we have Angela Hopp to thank. She        to these essays. Thank you for sharing
        created an essay contest, asking our     your stories and aha moments with us
        members to reflect on their careers      and reminding me just how grateful I
        or those of scientists they respect      am for mine.
        and to write about the aha moment
        that sparked a shift in their work.
        It could be any kind of revelation       Allison Frick (africk@
                                                 asbmb.org) is the ASBMB’s
        that changed the trajectory of their     multimedia and social media
        research or life. We received dozens     content manager. Follow her on
        of submissions. Wow. Thank you to        Twitter @allisonfrick.

        all who contributed. It wasn’t easy to

        MAY 2021                                                                                                                                                                                                                                                               ASBMB TODAY   3
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
MEMBER UPDATE

      Hanawalt, Nagata and                        for cellular apoptosis.” Nagata and        that university’s new Fisher Center
                                                  his lab described a membrane protein       named professorship for neurode-
      Regev named AACR fellows                    called the Fas receptor as a cell death    generative disease research.
         The American Association for             receptor; after binding to its ligand,         Strickland’s lab studies the con-
      Cancer Research announced in March          which Nagata’s lab also identified,        tribution of vascular dysfunction to
                          the new class of        Fas initiates an extrinsic cell death                           the development
                          fellows in its AACR     pathway that is crucial for immune                              of Alzheimer’s dis-
                          Academy, which          control of tumors.                                              ease; they found
                          recognizes scientists      Nagata is a member of the Japan                              that beta-amyloid
                          whose contribu-         Academy and a foreign associate of                              protein can
                          tions have led to       the U.S. National Academy of Sci-                               promote clotting
                          progress against        ences.                                                          and inflammation
                          cancer. Three              Aviv Regev has been the executive                            in the brain by in-
           HANAWALT       American Society        vice president of Genentech Research            STRICKLAND      teracting with fi-
                          for Biochemistry        and Early Development since 2020.                               brinogen and acti-
      and Molecular Biology members —             The AACR honors her for “devel-            vating coagulation factor FXII. The
      Philip Hanawalt, Shigekazu Nagata           oping and applying sophisticated           work has suggested new molecular
      and Aviv Regev — are among the              computational modeling techniques          mechanisms for the widely studied
      class of 25 fellows.                        and algorithms to understand mo-           β-amyloid protein to contribute to
         Philip Hanawalt is an emeritus           lecular circuits and predict cellular      Alzheimer’s pathogenesis and has
      professor of biology at Stanford Uni-                           behavior.” While       linked the disease to other common
      versity. The AACR is honoring him                               a professor at the     maladies of aging, such as hyperten-
      for his contributions to DNA damage                             Broad Institute and    sion and cardiovascular disease.
      repair. He co-discovered the ubiqui-                            Massachusetts In-          The position, funded by the Fish-
      tous process of DNA excision repair                             stitute of Technol-    er Center for Alzheimer’s Research
      in 1964 and also discovered transcrip-                          ogy and a Howard       Foundation, will support research
      tion-coupled repair, which removes                              Hughes Medical         into neurodegenerative diseases. It
      transcription-blocking damage from                              Institute investiga-   extends the Fisher Center’s partner-
      the template strands of expressed                 REGEV         tor, Regev led a       ship with Rockefeller University;
      genes. His work has furthered our un-                           lab that developed     the university is also home to the
      derstanding of the role of unrepaired       high-throughput single-cell sequenc-       foundation’s flagship lab of 40 scien-
                          DNA damage in           ing technologies and conducted             tists focused on Alzheimer’s disease.
                          oncogenesis.            systems modeling to understand cells’      Strickland has been a member of
                              Hanawalt is a       responses to varying stimuli. She co-      the Fisher Center’s neuroscience
                          fellow of the Ameri-    leads the Human Cell Atlas project,        advisory committee since 2019.
                          can Academy of          a multinational research consortium
                          Arts and Sciences,      that aims to define each cell type in
                          a member of the         the human body.
                                                                                             Blind recognized by GSA
                          National Academy           Regev is a member of the National           Raymond D. Blind, an assistant
            NAGATA        of Sciences, and a      Academy of Sciences and the National       professor at Vanderbilt Univer-
                          past member of the      Academy of Medicine.                       sity, was named in early March a
      AACR’s board of directors. He is a                                                     member of the inaugural cohort for
      senior editor for the journal Cancer        Strickland to hold                         the Genetics Society of America’s
      Research.                                                                              Presidential Membership Initiative.
         Shigekazu Nagata is a distinguished
                                                  new professorship                          This competitive program aims
      professor of biochemistry and immu-             Sidney Strickland, a professor,        to diversify the GSA membership
      nology at the Immunology Frontier           dean of graduate and postgraduate          while providing professional-devel-
      Research Center of Osaka University         studies, and vice president for educa-     opment programming and support
      in Japan. He is honored by the AACR         tional affairs at Rockefeller Univer-      for early-career scientists.
      for “categorizing crucial steps required    sity, will be the first person to hold         Blind’s lab studies how nuclear

4   ASBMB TODAY                                                                                                              MAY 2021
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
MEMBER UPDATE

inositides and inositols regulate chro-     in biology from Williams College, a        metabolite converted into NADH
matin-bound proteins. He recently           master’s degree in biology from Case       during cellular respiration. NAD+
completed a two-year stint as a junior      Western Reserve University and a           declines with age in both mice and
associate editor for the Journal of         Ph.D. in genetics from the University      the roundworm Caenorhabditis el-
Lipid Research, an American Society         of Wisconsin.                                                  egans. When it is
for Biochemistry and Molecular Biol-           Research in the Hazelbauer lab                              missing, glycolysis
                    ogy publication.        at the MU School of Medicine and                               can slow down.
                        Blind gave a talk   the College of Agriculture, Food                               McReynolds’
                    titled “The acyl        and Natural Resources focuses on                               research explores
                    chains of phos-         elucidating molecular mechanisms of                            how the result-
                    phoinositides alter     transmembrane receptors and sensory                            ing energy deficit
                    the structure and       transduction in bacterial chemotaxis.                          might contribute
                    function of nuclear     A number of recent projects have used         MCREYNOLDS       to cellular ageing
                    receptor steroido-      the emerging technology of nanodiscs                           and whether it
      BLIND         genic factor-1” at a    to manipulate membrane proteins in         can be reversed. She also has pub-
                    special session on      a water-soluble state.                     lished extensively on mentoring and
lipid diversity and disease at the 2021        Hazelbauer is making an initial         improving the equity of scientific
ASBMB Annual Meeting.                       $20,000 donation to LTHS this year,        training.
                                            which will support creative projects of       The move is a homecoming
Hazelbauer pledges                          several of the school’s science teach-     of sorts: McReynolds earned her
                                            ers. He has pledged to give at least the   Ph.D. in biochemistry, molecular
$1 million to high school                   same amount each year while he and         biology and microbiology at Penn
    Gerald Hazelbauer, a curators’                             his wife are alive,     State in 2017. She served as the
distinguished professor emeritus of                            prior to the $1 mil-    president of the Black Graduate
biochemistry at the University of                              lion posthumous         Student Association during her
Missouri, plans to donate $1 million                           donation.               time in State College. She arrived
to foster innovative science teaching                              A member of the     at Penn State through a Bridges to
at Lyons Township High School in                               American Society        the Doctorate program with Alcorn
Illinois.                                                      for Biochemistry        State University in
    Hazelbauer, a 1962 graduate of                             and Molecular           Mississippi, where she earned her
the school, is making the bequest in           HAZELBAUER      Biology since 1984,     bachelor’s and master’s degrees. Her
honor of Ruth Wenner, his fresh-                               Hazelbauer is also      awards as a graduate student in-
man biology teacher, according to           a fellow of the American Association       cluded an award from the Alfred P.
an article in the Riverside/Brookfield      for the Advancement of Science             Sloan Foundation Minority Ph.D.
Landmark.                                   and of the American Academy of             Program; as a postdoc, she has
    Wenner, described by Hazelbauer         Microbiology.                              received a Howard Hughes Medical
as an innovative and challenging                                                       Institute Hanna Gray fellowship
teacher who treated her students            McReynolds to join faculty                 and the Burroughs Wellcome Fund
like scientists, arranged for him to                                                   Postdoctoral Enrichment Program
accompany her to some laboratory            at Penn State                              award.
sessions of a summer course for                Melanie McReynolds, a postdoc-             Department chair Wendy
teachers at the Illinois Institute of       toral fellow at Princeton University,      Hanna–Rose was McReynolds’
Technology after his freshman year.         will join the faculty at Pennsylvania      dissertation adviser. “Dr. McReyn-
The following year, she gave him the        State University’s department of           olds is a creative and collaborative
opportunity to be student leader of a       biochemistry and molecular biology,        researcher of exceptional promise,”
high school research project funded         taking a named early-career chair, in      she stated in a Penn State news
by the National Science Teachers’           January of next year.                      release. “As a graduate student, she
Association through the Future Sci-            McReynolds studies the metabolic        was well known and recognized
entists of America Foundation. He           changes that occur during aging,           across campus for her activism and
went on to earn a bachelor’s degree         focusing on NAD+, the essential            leadership.”

MAY 2021                                                                                                             ASBMB TODAY   5
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
MEMBER UPDATE

      Passano Foundation                     Goldberg’s wide-ranging work has           Each year, the Alfred P. Sloan
                                             had a major impact on many areas        Foundation provides fellowships
      honors Goldberg                        of biology, medicine and biotech-       to promising scientific researchers
         Alfred Goldberg, professor of       nology.                                 whose achievements and potential
      cell biology at Harvard Medical                                                place them among the next genera-
                          School, won the    Derbyshire named                        tion of scientific leaders in the U.S.
                          2021 Passano                                               and Canada. Winners each receive
                          Award, which       Sloan fellow                            $75,000, which may be spent over
                          is presented           Emily Derbyshire, an assistant      a two-year term on any expense
                          by the Passano     professor of chemistry at Duke          supportive of their research.
                          Foundation to a    University, is one of 128 early-
                          researcher who     career scholars who are winners         Kornfeld and Dahms
                          has made an        of the 2021 Sloan Research
           GOLDBERG       exceptional con-   fellowships.
                                                                                     named to M6P board
                          tribution to the       Derbyshire earned her Ph.D.             The Missouri-based biotechnol-
      advancement of medical science.        from the University of California,      ogy company M6P Therapeutics,
         Goldberg was recognized for in-                         Berkeley, in        which develops enzyme and gene
      troducing the proteasome inhibitor                         2008 and then       therapies for lysosomal storage
      MG132, now very widely used as                             held a National     disorders, has appointed a scien-
      a research tool, and initiating the                        Institutes of       tific advisory board of geneticists
      research that led to the develop-                          Health postdoc-     and glycobiologists including two
      ment of the inhibitor bortezomib,                          toral fellowship    American Society for Biochemistry
      which is used worldwide in the                             in biological       and Molecular Biology members,
      primary treatment of the blood                             chemistry and       Stuart Kornfeld and Nancy
      cancer multiple myeloma.                   DERBYSHIRE      molecular           Dahms.
         Goldberg’s major discoveries                            pharmacology            The company is named for
      have concerned the biochemical         at Harvard Medical School from          the sugar mannose-6-phosphate,
      mechanisms and physiological           2009 to 2014. She was a scholar in                          which acts as
      regulation of protein breakdown        residence in the chemistry depart-                          a signal flag to
      in cells and the importance of this    ment at Duke’s Trinity College of                           promote traffick-
      process in human disease.              Arts and Sciences before joining                            ing of enzymes
         His laboratory first discovered     the faculty. She is also an assistant                       destined for
      the ATP-dependent system for           professor in molecular genetics and                         the lysosome.
      protein breakdown, now termed          microbiology and an associate of                            Without the
      the ubiquitin–proteasome path-         the Duke Initiative for Science and                         sugar, enzymes
      way. They first demonstrated the       Society.                                     KORNFELD       don’t make it to
      involvement of the proteasomes             Derbyshire’s lab studies novel                          the lysosome —
      in this process and discovered the     aspects of malaria parasite biology     and absence of certain enzymes can
      ATP-dependent proteases respon-        with the aim of identifying drug-       cause lysosomal buildup of their
      sible for protein degradation in       gable targets. They develop pheno-      substrates. Lysosomal storage disor-
      bacteria and mitochondria.             typic and target-based screens to       ders are generally rare diseases but
         Also of great impact have been      discover small molecules that can       can be very serious. The company
      his findings about the mechanisms      be leveraged to elucidate biological    is developing a gene therapeutic
      for the excessive protein degrada-     pathways. Their efforts integrating     approach that expresses both a
      tion and muscle atrophy in many        biochemistry, microbiology and          missing lysosomal enzyme and a
      disease states and their elucidation   chemical biology have revealed          phosphotransferase that enables
      of the role of the proteasome and      parasite and human proteins             proper lysosomal targeting.
      cellular peptidases in antigen pre-    that are important for pathogen
      sentation to the immune system.        infection.                              CONTINUED ON PAGE 8

6   ASBMB TODAY                                                                                                     MAY 2021
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
MEMBER UPDATE

     American Academy of Microbiology inducts fellows

     T
           he American Academy of Microbiology has elected 65 new fellows into its class of 2021. The academy, an
           honorific leadership group of the American Society for Microbiology, elects microbiologists annually through peer
           review. Five of this year’s AAM fellows are American Society for Biochemistry and Molecular Biology members.

     Julie Maupin–Furlow is a                                        of Medicine. Her lab pursues broad-based research
     professor of microbiology                                       on inflammatory diseases, including studying the
     and cell science of the Uni-                                    contribution of epigenetic modifications and other
     versity of Florida’s Institute                                  regulatory genes in inflammation and seeking
     of Food and Agricultural                                        small-molecule treatments for several types of can-
     Sciences. She is known                                          cers and cancer immunotherapy. She is a fellow of
     for her lab’s biochemical                                       the American Association for the Advancement of
     and proteomic character-                                        Science and has received numerous research awards.
     ization of archaeal protein turnover through the
     proteasome–ubiquitin system. The work, which                    Mario Feldman is a profes-
     uses extremophiles from environments like the                   sor of molecular micro-
     hypersaline Dead Sea, is relevant to bioenergetic               biology at Washington
     research, aiming to generate renewable fuels, as well           University in St. Louis,
     as to astrobiological research. Maupin–Furlow is a              where he studies patho-
     member of the Archaeal Proteome Project, has or-                genic Gram-negative
     ganized Gordon Research Conferences and received                bacteria, some of which
     her university’s UF Research Foundation award in                frequently cause hospital-
     2010.                                                           acquired infections. Feldman’s lab works to develop
                                                                     new antimicrobials by better understanding bacte-
     Kenneth Marians is a profes-                                    rial secretion systems, virulence factors and outer
     sor at Memorial Sloan                                           membrane vesicles. Feldman also co-founded a
     Kettering Cancer Center in                                      biotechnology startup called VaxNewMo in 2016
     New York and a leader in                                        and serves as chief scientific officer; the company
     the field of DNA replica-                                       aims to use glycoengineering to produce vaccines
     tion. He served as chair                                        that more closely resemble true bacterial antigens.
     of the molecular biology
     program for 25 years and                                        Sarah Gaffen is the Gerald
     was the founding dean of the Louis V. Gerstner Jr.              P. Rodnan endowed
     Graduate School of Biomedical Sciences. He is now               professor of rheumatology
     back in the lab full time.                                      and clinical immunol-
                                                                     ogy at the University
     Mitzi Nagarkatti is Carolina                                    of Pittsburgh and the
     distinguished professor                                         director of the Pittsburgh
     and SmartState endowed                                          Autoimmunity Center of
     chair of the Cancer Drug                                        Excellence in Rheumatology. Her lab was among
     Discovery SmartState Cen-                                       the first to study interleukin-17 and continues to
     ter as well as chair of the                                     study the role of this cytokine, and the T cells that
     department of pathology,                                        produce it, in host defense from fungal infection
     microbiology and immu-                                          and also, when unchecked, autoimmune disorders
     nology at the University of South Carolina School               such as psoriasis.

MAY 2021                                                                                                                  ASBMB TODAY   7
ASBMB FELLOWS Meet the inaugural - FIRST CLASS - American Society for Biochemistry and ...
MEMBER UPDATE

      CONTINUED FROM PAGE 6                          served on numerous research review           in Kornfeld’s lab at WashU in
                                                     boards for awards and granting               the 1980s. As a postdoc, she
          The scientific board’s chairman                               agencies. In 2012,        characterized mannose-6-phosphate
      is also the company’s co-founder,                                 he received the           receptors that govern lysosomal
      glycobiologist Stuart Kornfeld,                                   Herbert Tabor             enzyme targeting. She has studied
      a professor at Washington                                         Research Award            glycoproteins and their receptors
      University Medical School in St                                   from the ASBMB.           ever since, becoming a leading
      Louis. Kornfeld, who has taught                                      Board member           expert in Fabry disease, a lysosomal
      at WashU since 1967, has a long                                   Nancy Dahms, a            storage disorder caused by buildup
      history of service to the field.                                  professor at the          of a glycosphingolipid when a
      He served several terms on the                      DAHMS         Medical College           certain lysosomal glycan-digesting
      editorial board of the Journal of                                 of Wisconsin,             enzyme is mutated or absent. She
      Biological Chemistry, including a              has studied lysosomal storage                is the 2021 president of the Society
      term as an associate editor, and has           diseases since she was a postdoc             for Glycobiology.

      IN MEMORIAM
          Robert Baldwin

              Robert Lesh Baldwin, a founding member of Stanford           who were moving to Stanford to
          University’s biochemistry department and a member of the         establish a biochemistry depart-
          ASBMB since 1957, died March 6 at his home in Portola            ment. Baldwin began his tenure at
          Valley, California. He was 93.                                   Stanford as an associate professor
              “Baldwin devoted his career to studying how proteins,        and was promoted to full professor
          which begin life as linear chains of chemical building           in 1964.
          blocks, quickly assume their characteristic highly complex,          In 1965, he married Anne Norris,
          functional structures,” an article posted on the Stanford        a postdoc in the lab of Paul Berg.
          Medicine news website stated. “His research sped a shift         (Another member of the Stanford biochemistry founding group,
          in many biologists’ attention from organismic biology, the       Berg went on to win the 1980 Nobel Prize in chemistry.) Norris
          study of creatures great and small, to molecular biology,        had been offered a faculty position at Harvard that year but
          which focuses on the individual biochemical reactions that       chose to stay in California.
          underpin all living processes and on the molecules — usually         Baldwin served as Stanford’s biochemistry department
          proteins — responsible for catalyzing those reactions.”          chair from 1989 through 1994. He was a member of the
              Born Sept. 30, 1927, in Madison, Wisconsin, Baldwin          National Academy of Sciences and of the American Academy
          was nicknamed “Buzz” by one of his sisters. He earned a          of Arts and Sciences and a fellow of the Biophysical Society. He
          bachelor’s degree in chemistry at the University of Wiscon-      received the Stein and Moore Award of the Protein Society in
          sin before attending the University of Oxford as a Rhodes        1992 and the Wheland Award in chemistry in 1995.
          scholar, where he received his D.Phil. in biochemistry. He did       He had been an emeritus professor since 1998 and, ac-
          a postdoc in physical chemistry at the University of Wiscon-     cording to Berg, continued to make major theoretical advances
          sin and then joined that school’s faculty.                       until the last five years of his life.
              In 1958, Arthur Kornberg invited Baldwin to join a group         In addition to his wife, Baldwin is survived by two sons,
          of researchers from Washington University in St. Louis           David and Eric, and five grandchildren.

8   ASBMB TODAY                                                                                                                      MAY 2021
RETROSPECTIVE

Remembering Curtiss, former JLR associate editor
By Angela Hopp
                                                                                   for Women in Science and, in the

L
       inda Kay Curtiss, a professor                                               1980s, served on the board of the San
       at Scripps Research in Califor-                                             Diego chapter.
       nia, died Feb. 23 of cancer. She                                               For decades, Curtiss served as an
was 77.                                                                            editorial board member and associate
    Curtiss studied plasma lipopro-                                                editor for the JLR.
teins, inflammation and innate im-                                                    Kerry-Anne Rye, who became
munity in atherosclerosis. She was a                                               JLR’s co-editor-in-chief in 2020, is
former associate editor for the Ameri-                                             a longtime friend and colleague of
can Society for Biochemistry and                                                   Curtiss. She said that Curtiss was a
Molecular Biology’s Journal of Lipid                                               role model for her and other women
Research, a champion of women in          they rolled the stairs out to meet you   in their field.
science, and an advocate for robust       — the sun hit my eyes, I smelled the        “This is a huge loss. I’m going to
federal funding for research.             ocean, and I immediately thought,        miss her a lot, but I fortunately got
    Curtiss was born in 1943 to Ruby      ‘This is where I’m going to stay.’”      to see her for the last time during my
and Glenn Curtiss in Seattle and             Indeed, she did. She won a faculty    final pre-COVID trip to the U.S. It
raised in Kirkland, Washington. She       position at Scripps’ immunology and      was just a few days before everything
attended and held leadership posi-        microbiology department and started      was locked down. Talk about impec-
tions and participated in sports at       her own lab in 1978.                     cable timing,” Rye said.
Lake Washington High School, where           Curtiss was a committed volun-           She also said that Curtiss’ early love
her mother taught biology. She gradu-     teer and leader for the American         of athletics never faded.
ated in 1962.                             Heart Association, which ultimately         “One of the first times I went to
    Curtiss earned her bachelor’s         made her an elected fellow and           visit Linda in San Diego, she was
degree in zoology at the University of    gave her three awards for her body       in a great hurry to get to a baseball
Washington in 1966 and then earned        of work and her service: the Dis-        game, so we went straight there from
a master’s degree in biology at the       tinguished Achievement Award in          the airport. I thought we would be
University of Colorado Boulder in         2006, the Mentor of Women Award          spectators. That was certainly the
1968.                                     in 2004 and the Special Recognition      case for me, but she was one of the
    She spent six months in Europe        Award in 2000.                           players!” Rye said. “Actually, her main
and another six in Africa before             With the AHA, Curtiss on mul-         sporting passion was golf, which she
returning to UW for her Ph.D. She         tiple occasions visited Capitol Hill     played with huge enthusiasm for
finished her thesis on immunochem-        and talked to lawmakers about her        many years.”
istry while doing a research fellowship   work, federal spending priorities and       Curtiss retired from Scripps in
at the Mayo Clinic in Minnesota in        science policy.                          2014 and remained in San Diego.
1974.                                        For most of the 1990s, Curtiss           She is survived by her wife of
    For postdoctoral studies, she         held leadership positions on the         four decades, Jeanne Niosi, a sister
moved to Scripps to work on               advisory board for the Deuel Confer-     and a brother, and many nieces and
plasma lipoproteins in the lab of         ence on Lipids. She also served on       nephews.
Tom Edgington.                            numerous National Institutes of
    “I left the Mayo Clinic in a bliz-    Health study sections and review         Angela Hopp (ahopp@
                                                                                   asbmb.org) is executive
zard in 1974,” she said in an interview   committees.                              editor of ASBMB Today and
with Scripps’ online weekly back in          Curtiss also was committed to         communications director for
2007. “I stepped off the plane in San     supporting other women in science.       the ASBMB. Follow her on
                                                                                   Twitter @angelahopp.
Diego — those were the days when          She was a member of the Association

MAY 2021                                                                                                         ASBMB TODAY   9
FIRST CLASS

                             Meet the inaugural
                   ASBMB FELLOWS
                   Introduction by Judith Bond & Edward Eisenstein

                   T
                          he title of fellow has a long history in academia and professional
                          societies and typically designates distinguished members or partners
                          who have contributed significantly to a field or endeavor. Over the past
                   year, the leadership of the American Society for Biochemistry and Molecular
                   Biology established a fellows program to recognize members of our society
                   who have demonstrated exceptional commitment to the ASBMB and made
                   outstanding contributions to advance the molecular life sciences.
                       The Membership Committee took on the responsibility of implementing
                   the program by defining criteria and developing a process for selection of the
                   fellows. The committee decided that fellows should demonstrate exceptional
                   service through active participation and leadership in ASBMB programs
                   and should personify the core values of the ASBMB through scientific
                   achievements, educational endeavors, mentorship, commitment to diversity,
                   and/or service to the society and the scientific community. Our objective was
                   to select fellows who represent the breadth and diversity of the society’s
                   membership and all its missions.
                       A call for nominations for fellows was announced electronically to
                   members in society publications (including ASBMB Today) and on our
                   website. Nominations were accepted from regular, industry and emeritus
                   ASBMB members in good standing. There was an immediate and robust
                   response. It became obvious that our society has a very large number of
                   accomplished members who have served the ASBMB and advanced the life
                   sciences in many ways. A subgroup of the Membership Committee screened
                   and assessed the candidates, the assessments were then discussed with
                   the whole committee, and finally a list of 30 candidates (out of about 100
                   nominees) was submitted to and approved by the ASBMB Council. The list
                   was announced during the 2021 ASBMB annual meeting in late April.
                       The 2021 fellows are indeed a distinguished group of scientists who have
                   contributed to multiple missions of our society over a sustained period of
                   time and enriched our world through their efforts and accomplishments.
                   It was an honor to be part of the process to recognize this group, and their
                   contributions make us proud to be members of the ASBMB.

10   ASBMB TODAY                                                                        MAY 2021
ASBMB FELLOWS

Natalie Ahn, University of Colorado Boulder                  Teaster Baird Jr., San Francisco State University
   Natalie Ahn is a distinguished                                Teaster Baird Jr. is a professor
professor of biochemistry at the Uni-                        and chair of the department of
versity of Colorado Boulder. Her lab                         chemistry and biochemistry at San
merges proteomics, cell biology and                          Francisco State University. A dedi-
biophysical approaches to investigate                        cated educator who has led many
signal-transduction mechanisms, par-                         initiatives within and beyond his
ticularly those implicated in cancer.                        university to improve science educa-
   Ahn served as president of the American Society           tion, Baird also maintains a research program in serine
for Biochemistry and Molecular Biology from 2016             protease enzymology, examining and engineering the
to 2018. Before that she was a member of the society’s       enzymes to modify their catalytic activity, substrate speci-
Council. She was nominated to be an ASBMB fellow by          ficity and interactions with macromolecular inhibitors.
Ruma Banerjee, who wrote: “Natalie worked tirelessly to          Baird has served the ASBMB as the Southwest regional
enhance the status of the national meeting and selected a    director of Student Chapters for at least six years and
new editor-in-chief for (the ASBMB’s) flagship journal,      remains the faculty adviser for his university’s Student
JBC, which ushered in sweeping and positive changes.         Chapter. For 10 years, he served on the steering commit-
… Natalie’s scientific record is stellar. … She is most      tee that developed concept-driven teaching strategies in
deserving of the recognition that would be conferred as      biochemistry and molecular biology.
an ASBMB fellow.”                                                He was nominated to be an ASBMB fellow by a panel
   She earned her Ph.D. from the University of Califor-      of seven colleagues from SFSU and the ASBMB Student
nia, Berkeley, and did postdoctoral work at the University   Chapters program, who wrote that “he sees potential,
of Washington.                                               provides opportunities, and gives a voice to students and
                                                             faculty who often are forgotten or overlooked … (and)
Karen Allen, Boston University                               is constantly pushing the boundaries of the way students
    Karen Allen is a professor and                           are educated.”
chair of the chemistry department                                Baird earned his Ph.D. from Duke University and was
at Boston University. Her lab uses                           a postdoctoral fellow both at Duke and at the University
structural biology techniques to                             of California, San Francisco.
study enzyme evolution and sub-
strate specificity, with a longstanding                      Ruma Banerjee, University of Michigan
focus on the haloalkanoate dehaloge-                            Ruma Banerjee is a professor of
nase superfamily. Her lab also has designed inhibitors for   biological chemistry at the Univer-
several enzymes from pathogens that cause understudied       sity of Michigan whose lab studies
diseases such as elephantiasis.                              the enzymes that metabolize and
    Allen is a former member of the ASBMB Council            transform sulfur-containing com-
and secretary of the society and a founding member of        pounds. Her work focuses especially
the Women in Biochemistry and Molecular Biology              on coenzymes, notably vitamin
Committee.                                                   B12, or cobalamin.
    She was nominated to be an ASBMB fellow by Ann              Banerjee was nominated to be an ASBMB fellow by
Stock and Tina Iverson, who wrote that Allen “is a superb    Tina Iverson, who wrote, “Ruma is a mover and shaker in
scientist who has made fundamental contributions to the      enzymology … (who) has maintained this field-leading
field of enzymology … has her pulse on the leading ques-     research program in the context of extensive service to
tions of the field and is an investigator with the highest   her home institutions and the world at large.”
integrity and values.”                                          Among her many service projects, Banerjee has served
    Allen earned her Ph.D. at Brandeis University and did    on the ASBMB Council and Minority Affairs Commit-
postdoctoral training at the Massachusetts Institute of      tee; is the founding co-PI of the society’s Maximizing
Technology.                                                  Opportunities for Scientific and Academic Independent

MAY 2021                                                                                                      ASBMB TODAY   11
ASBMB FELLOWS

       Careers, or MOSAIC, program; and is an associate editor     biology, and he also played a key role in developing the
       of the Journal of Biological Chemistry. She has been the    ASBMB accreditation program.
       recipient of numerous awards, including, in 2019, the          Bell was nominated as an ASBMB fellow by Marilee
       ASBMB–Merck Award, which recognizes outstanding             Benore, who wrote, “Ellis’ gift is his ability to step back
       contributions to research in biochemistry and molecular     and allow faculty to work within the strategic outline to
       biology.                                                    create change, develop professionally and then step into
          Banerjee earned her Ph.D. at Rensselaer Polytechnic      their own leadership roles.”
       Institute and was a postdoctoral fellow at the University      Bell earned his doctorate at Oxford University and did
       of Michigan.                                                postdoctoral research at Duke University.

       Suzanne Barbour, University of North Carolina               Squire Booker, Pennsylvania State University
       at Chapel Hill                                                  Squire Booker is a professor and
          Suzanne Barbour is the dean of                           distinguished chair at Pennsylvania
       the graduate school and a professor                         State University, where his lab studies
       at the University of North Carolina                         the catalytic mechanisms of redox
       at Chapel Hill.                                             enzymes involved in natural product
          Barbour served on the ASBMB                              biosynthesis and human health. He
       Education and Professional Devel-                           is also a Howard Hughes Medical
       opment Committee for 12 years.                              Institute investigator.
       She is now a member of the Minority Affairs Committee           Booker has chaired the ASBMB’s Minority Affairs
       and the Council. Barbour serves on the Annual Meeting       Committee and was the founding principal investiga-
       Program Planning Committee and organized scientific         tor on the ASBMB Interactive Mentoring Activities for
       sessions for the 2020 annual meeting. She has been on the   Grantsmanship Enhancement grant writing workshop.
       Journal of Lipid Research editorial board for almost 14     He also co-organized the 2016 ASBMB annual
       years.                                                      meeting. He now serves on the Finance and Nominating
          She was nominated to be an ASBMB fellow by Sterling      committees.
       Bradley, who wrote that Barbour “is a recognized national       Booker was nominated to be an ASBMB fellow by
       advocate for many aspects of career development and         Ruma Banerjee, who wrote, “Squire’s work is character-
       the challenge facing working scientists and the coming      ized by its elegance and rigor. … His research productivity
       generation of scientists.”                                  is all the more impressive given his heavy teaching load
          Barbour earned her Ph.D. at Johns Hopkins University     and service commitments both at Penn State and
       and did postdoctoral training at the University of Cali-    nationally.”
       fornia, San Diego. She has been a program director at the       Booker earned his Ph.D. at the Massachusetts Insti-
       National Science Foundation and a dean at the University    tute of Technology and did postdoctoral research at the
       of Georgia.                                                 Université René Descartes in Paris and the University of
                                                                   Wisconsin. He is an elected member of the American
       J. Ellis Bell, University of San Diego                      Academy of Arts and Sciences and the National Academy
          J. Ellis Bell is a lecturer at the                       of Sciences.
       University of San Diego. A dedi-
       cated educator, Bell has published                          George Carman, Rutgers University
       extensive pedagogical research and                             George Carman is a professor at
       also pursues structural biology stud-                       Rutgers University and director of the
       ies in a lab jointly run with his wife,                     university’s Center for Lipid Research.
       USD professor Jessica Bell.                                 He has made seminal contributions
          Ellis Bell won the 2015 ASBMB Award for Exemplary        to the understanding of the regula-
       Contributions to Education. That award recognized his       tion of phospholipid synthesis using
       service to biochemistry education as a long-serving mem-    the yeast Saccharomyces cerevisiae.
       ber of the Education and Professional Development Com-      His group identified the molecular function of the yeast
       mittee; he led the committee that developed concept-        version of mammalian lipins, phosphatidic acid phospha-
       driven teaching strategies in biochemistry and molecular    tase enzymes that are crucial regulators of fat metabolism.

12   ASBMB TODAY                                                                                                     MAY 2021
ASBMB FELLOWS

   Carman is a repeat associate editor for the society’s    Enrique M. De La Cruz, Yale University
Journal of Lipid Research and is a former associate edi-       Enrique M. De La Cruz is a
tor for its Journal of Biological Chemistry. He won the     professor at Yale University, where
society’s 2012 Avanti Award in Lipids, which recognizes     he leads the molecular biophysics
outstanding research contributions in the area of lipids.   and biochemistry department and
   He also has served on and as chair of the society’s      Branford College. His lab studies the
Meetings Committee and Annual Meeting Program               actin cytoskeleton, molecular motor
Planning Committee. He also has been a member of the        proteins and nucleotide signaling
ASBMB Council and Awards Committee and co-orga-             enzymes.
nized numerous society events.                                 De La Cruz is an associate editor for the Journal of
   Alfred H. Merrill Jr. at Georgia Tech University         Biological Chemistry and an advisory board member for
nominated Carman to be an ASBMB fellow. “George             the society’s Maximizing Opportunities for Scientific and
has made impressive contributions to science through        Academic Independent Careers, or MOSAIC, program.
both the discoveries of his laboratory and his assistance   He previously served on and chaired the society’s Publica-
to others through these activities,” he wrote.              tions Committee, served on the Meetings Committee,
   Carman earned his master’s degree from Seton Hall        co-organized a 2013 annual meeting thematic session and
University before going on to complete his Ph.D. at the     co-organized the 2014 annual meeting.
University of Massachusetts. He did postdoctoral work          Mark Hochstrasser at Yale nominated De La Cruz to
at the University of Texas Medical School in Houston.       be an ASBMB fellow. “Enrique is an active member of
                                                            the ASBMB and is an exemplary scientist in his research,
Michael Cox, University of Wisconsin–Madison                teaching and training, particularly of underrepresented
    Michael Cox is an endowed                               scientists. … He has done an enormous amount of
professor in the University of                              work in helping to build diversity both here at Yale and
Wisconsin–Madison department                                elsewhere.”
of biochemistry. His lab studies                               De La Cruz earned his Ph.D. at the Johns Hopkins
DNA replication and repair and                              University School of Medicine and completed postdoc-
is best known for contributions to                          toral training at the University of Pennsylvania.
understanding the RecA and Flp
recombinases, which have become widely used tools           Edward Dennis, University of California, San Diego
for biotechnology and developing transgenic model              Edward Dennis is a distinguished
organisms.                                                  professor at the University of
    Cox served as a member of the ASBMB Council and         California, San Diego. He has made
an associate editor of the Journal of Biological Chem-      important contributions to the study
istry; he was a member of the steering committee that       of lipid metabolism and cell signaling
developed concept-driven teaching strategies in bio-        through his research on phospholi-
chemistry and molecular biology and continues to advise     pase A2 enzymes. Importantly, he
his university’s ASBMB Student Chapter. He has served       pioneered the lipidomics movement.
for many years as a judge in the undergraduate research        Dennis has been a member of the ASBMB Council
poster competition at the ASBMB annual meeting.             and served as the first chair of the ASBMB Annual Meet-
    UW–Madison colleague Aaron Hoskins, who                 ing Program Planning Committee, program chair of the
nominated Cox as an ASBMB fellow, wrote, “Mike is a         1996 annual meeting, and on the society’s Membership
remarkable scientist. … From writing a grant to writing     Committee, Education and Professional Development
an exam, Mike has been an exceptional scientific role       Committee, and Finance Committee. He was a mem-
model in every way.”                                        ber of the Publications Committee when the society
    Cox earned his Ph.D. at Brandeis University and was     started the journal Molecular & Cellular Proteomics and
a postdoctoral researcher at Stanford University School     acquired the Journal of Lipid Research, and he went on
of Medicine.                                                to serve as editor-in-chief of the JLR for 15 years. He also
                                                            served on the editorial board of the Journal of Biological
                                                            Chemistry. He won the society’s 2000 Avanti Award in
                                                            Lipids and its 2020/2021 Bert and Natalie Vallee Award

MAY 2021                                                                                                      ASBMB TODAY   13
ASBMB FELLOWS

       in Biomedical Science.                                             Dohlman has been an ASBMB member for more than
           George Carman nominated Dennis to be an ASBMB               three decades. He served multiple terms on the editorial
       fellow. “Numerous investigators have entered the field          board of the Journal of Biological Chemistry and today is
       of phospholipases and signal transduction as well as            an associate editor.
       lipidomics because of the contributions of Dr. Dennis,”            Jeremy Thorner, who nominated Dohlman as an
       Carman wrote. “These investigators do not even include          ASBMB fellow, wrote, “Henrik has made numerous
       the many graduate students and postdoctoral fellows that        path-finding contributions about what are now known as
       Dr. Dennis has mentored at the University of California         G-protein coupled receptors. … Moreover, in the process,
       at San Diego. The fact that many of his past students are       he has trained legions of his own Ph.D. students and
       now leaders in the field in their own right is testimony of     postdoctoral trainees.”
       his outstanding ability to train and motivate people.”             He earned his Ph.D. at Duke University and complet-
           Dennis earned his master’s degree and Ph.D. from            ed postdoctoral training at the University of California,
       Harvard University and completed postdoctoral training          Berkeley.
       at Harvard Medical School.
                                                                       William Dowhan, University of Texas Health Science
       John Denu, University of Wisconsin–Madison                      Center at Houston McGovern Medical School
           John Denu is a professor at the                                William Dowhan is an endowed
       University of Wisconsin‒Madison,                                professor in biochemistry and
       where his lab studies enzymes re-                               molecular biology at the University
       sponsible for adding and removing                               of Texas Health Sciences Center
       post-translational modifications.                               McGovern Medical School, where
       Recently, his team revealed new                                 his lab studies lipid‒protein interac-
       regulatory mechanisms that link                                 tions. His lab found that lipids are
       metabolism and chromatin function, opening up new               involved in proper folding of membrane proteins and that
       insights into diet, gut microbiota and the epigenome.           changes to the lipid environment can alter membrane
           Denu has served as an editorial board member and            protein activity.
       now is an associate editor of the Journal of Biological            Dowhan won the ASBMB’s 2005 Avanti Award in Lip-
       Chemistry. He also serves on the ASBMB Nominating               ids, which recognizes outstanding research contributions.
       Committee. He has organized both scientific sessions and        He has served on the society’s Meetings Committee and
       professional-development events for the ASBMB annual            organized a scientific symposium for the annual meeting.
       meeting.                                                        He is a past editorial board member for the Journal of
           Sharon Dent, who nominated Denu as an ASBMB                 Biological Chemistry.
       fellow, wrote, “John’s research is consistently trailblazing.      “Dr. Dowhan’s success lies in successfully challenging
       … John is a highly productive scientist … (who) is also         dogma … use of evolving technology and approaches …
       highly committed to teaching and mentoring.”                    and generating new concepts,” wrote George Carman,
           Denu earned his Ph.D. at Texas A&M University               who nominated Dowhan as an ASBMB fellow.
       and completed postdoctoral training at the University of           Dowhan earned his Ph.D. at the University of Califor-
       Michigan.                                                       nia, Berkeley, and did postdoctoral research at Harvard
                                                                       Medical School.
       Henrik Dohlman, University of North Carolina
          Henrik Dohlman is a professor                                Catherine Drennan, Massachusetts Institute
       at the University of North Caro-                                of Technology
       lina, Chapel Hill, where he chairs                                 Catherine Drennan is a profes-
       the pharmacology department and                                 sor at the Massachusetts Institute of
       studies G protein–coupled recep-                                Technology and a Howard Hughes
       tor signaling and desensitization                               Medical Institute investigator. She
       in yeast. His lab was the first to                              studies the structural biology of
       demonstrate G protein regulation by GTPase-activating           metalloenzymes. Her lab’s targets
       RGS proteins, mono- and poly-ubiquitination, and pro-           have included multiple enzymes that
       ton second messengers.                                          depend on metal cofactors, such as ribonucleotide reduc-

14   ASBMB TODAY                                                                                                       MAY 2021
ASBMB FELLOWS

tase, an early enzyme in DNA biosynthesis. Drennan           service to ASBMB and the scientific community. …
was once a high school science and drama teacher, and        Overall, the products of Dr. Sumter’s mentorship skills
she has remained committed to developing teaching            have established broad contributions and her widespread
best practices and research-based modules for students       impacts will continue to influence the next generation
ever since.                                                  of science education and production of scientists.”
   As a postdoctoral fellow in 1997, Drennan started            Sumter earned her Ph.D. at the University of South
the undergraduate poster competition at the ASBMB            Carolina and completed a postdoctoral fellowship at the
annual meeting. She ran it for the next five years. She      Johns Hopkins University School of Medicine.
also served on the ASBMB Education and Professional
Development Committee during the period when                 Karen Fleming, Johns Hopkins University
the society developed its undergraduate biochemistry            Karen Fleming is a professor at
curriculum recommendations. She later served on the          Johns Hopkins University and a
Publications Committee. In 2013, she co-organized            pioneer in the study of membrane-
a themed session on catalytic mechanisms for the             protein folding. Her lab focuses on
ASBMB annual meeting, and she is organizing one on           beta-barrel proteins of the bacterial
enzymology for the 2022 meeting.                             outer membrane and investigates
   In her nomination letter, Tina Iverson at Vander-         the structural basis of chaperone
bilt University noted Drennan’s “deep commitment             interactions with unfolded membrane proteins.
to education and inclusivity” and her “long service to          Fleming is an associate editor of the Journal of Bio-
ASBMB, her contributions to training, and her stature        logical Chemistry and a past member of the Council.
as a world leader in the field.”                             She has organized multiple meetings in protein biophys-
   Drennan earned her Ph.D. from the University of           ics, including events for the ASBMB, and she has been a
Michigan and completed her postdoctoral research at          vocal advocate for equity in scientific careers.
the California Institute of Technology.                         Cynthia Wolberger, who nominated Fleming as an
                                                             ASBMB fellow, wrote, “She has worked extensively
Takita Felder Sumter, Winthrop University                    on issues facing women in STEM … and has recently
   Takita Felder Sumter is the                               expanded her efforts to confront issues that face both
dean of the College of Arts & Sci-                           women and men of color.”
ences and a professor at Winthrop                               Fleming earned her Ph.D. at Georgetown University
University.                                                  and did postdoctoral training at Yale University.
   She has been deputy chair and
later chair of the ASBMB Minor-                              Lila M. Gierasch, University of Massachusetts Amherst
ity Affairs Committee. She was                                  Lila M. Gierasch is a distin-
instrumental in creating the society’s Marion B. Sewer       guished professor and former
Distinguished Scholarship for Undergraduates and             department head at the University
co-led the Interactive Mentoring Activities for Grants-      of Massachusetts Amherst. Her lab
manship Enhancement program. She helped organize             studies protein folding, investigat-
regional workshops and other activities that ultimately      ing the mechanisms of molecular
led to the creation of two new mechanisms to evalu-          chaperones and the effects of
ate student learning: the ASBMB degree-accreditation         misfolded protein aggregates.
program and the ASBMB certification exam.                       She has been the editor-in-chief of the Journal of
   She has been a regional director for the society’s Stu-   Biological Chemistry since 2016. She was the 2014
dent Chapters program, and she has served for the past       recipient of the ASBMB’s Mildred Cohn Award, which
decade and a half as a judge for the annual undergradu-      honors scientists who have made substantial advances
ate poster competition. Sumter is now on the ASBMB           in understanding biological chemistry using innovative
Council.                                                     physical approaches.
   Heather J. Evans Anderson at Stetson University,             Daniel Hebert, who nominated Gierasch as a fellow,
who nominated Sumter to be an ASBMB fellow, wrote:           wrote that, beyond her many accolades, “What is most
“Taken together these efforts exemplify Dr. Sumter’s         special about Lila are the so many things she does that
exemplary mentorship skills and her commitment to            do not show up on a resume. Beyond serving as an

MAY 2021                                                                                                   ASBMB TODAY   15
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