COVID-19 VACCINATION IN MANITOBA TECHNICAL BRIEFING - March 3, 2021

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COVID-19 VACCINATION IN MANITOBA TECHNICAL BRIEFING - March 3, 2021
COVID-19 VACCINATION IN MANITOBA
              TECHNICAL BRIEFING

March 3, 2021
COVID-19 VACCINATION IN MANITOBA TECHNICAL BRIEFING - March 3, 2021
OPERATIONAL UPDATES
VACCINE DELIVERY MODEL UPDATES
                                     Winnipeg                   Brandon                Thompson
SUPERSITES
In larger centres, supersites         6,945                      1,473                     350
allow for rapid and large-scale   DOSES ADMINISTERED       DOSES ADMINISTERED       DOSES ADMINISTERED
                                                                                       IN LAST WEEK
vaccination for increased            IN LAST WEEK             IN LAST WEEK
speed and efficiency.
                                      39,649                      5,279                     350
                                     TOTAL DOSES              TOTAL DOSES              TOTAL DOSES
                                     ADMINISTERED             ADMINISTERED             ADMINISTERED

                                        777                       165                       116
                                   AVG. DAILY DOSES         AVG. DAILY DOSES          AVG. DAILY DOSES

                                          55                       27                        14
   3                              EST. DAILY STAFF (FTE)   EST. DAILY STAFF (FTE)   EST. DAILY STAFF (FTE)
VACCINE DELIVERY MODEL UPDATES

FOCUSED                            • FITs will visit 120 congregate living facilities this week and administer
                                     about 4,800 residents
IMMUNIZATION                       • More than 7,800 second-doses in personal care home immunization
TEAMS (FITs)                         campaign
FITs visit facilities to deliver
vaccines where people live.        • All regional health authorities have scheduled prioritized congregate living
                                     sites this week.

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WORKFORCE RECRUITMENT

DAILY OPERATIONAL SCHEDULE                                   Overall, staffing is down due to lack of vaccine

    RBC CONVENTION CENTRE                 KEYSTONE CENTRE                         FIT TEAM - Winnipeg
               1060 Doses                           256 Doses                               535 Doses

                  71                                   31                                      12
          TOTAL STAFF (FTE)                     TOTAL STAFF (FTE)                       TOTAL STAFF (FTE)
          31 Immunizers (FTE)                   12 Immunizers (FTE)                     12 Immunizers (FTE)

CURRENT WORKFORCE
               2,224            165
                                            •
                                            •
                                                 1,647 immunizers
                                                 20 clinic managers
                 STAFF                      •    27 clinical leads
          As of March 1, 2021 this week     •    426 navigators
                                            •    104 observers
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COVID-19 DOSE DELIVERY SCHEDULE

                                                                               Doses Received & Projected
          60.0 K

          50.0 K

          40.0 K

          30.0 K

          20.0 K

          10.0 K

           0.0 K

               14-Dec-     21-Dec-   28-Dec-                                                                                                15-Mar- 22-Mar- 29-Mar-
                                             4-Jan-21 11-Jan-21 18-Jan-21 25-Jan-21 1-Feb-21 8-Feb-21 15-Feb-21 22-Feb-21 1-Mar-21 8-Mar-21                         5-Apr-21 12-Apr-21 19-Apr-21 26-Apr-21
                 20          20        20                                                                                                     21      21      21
 Moderna Doses 0.0 K        7.3 K     0.0 K    0.0 K    7.4 K     0.0 K     0.0 K     8.1 K    0.0 K    0.0 K     6.1 K     0.0 K   20.5 K   0.0 K   40.6 K  0.0 K    0.0 K    0.0 K     0.0 K     0.0 K
 Pfizer Doses      2.3 K   11.7 K     1.2 K    7.0 K    9.4 K    9.4 K     0.0 K    2.3 K    3.5 K    15.2 K   17.6 K   16.4 K    16.4 K   14.0 K   14.0 K   14.0 K    0.0 K    0.0 K     0.0 K    0.0 K
 Total             2.3 K   19.0 K     1.2 K    7.0 K    16.8 K   9.4 K     0.0 K   10.4 K    3.5 K    15.2 K   23.7 K   16.4 K    36.9 K   14.0 K   54.6 K   14.0 K    0.0 K    0.0 K     0.0 K    0.0 K

 As of March 2, 2021
SUPERSITE                                                                                                                                                      Closing Stock Balance - Supersites

INVENTORY                        12,000                                                                                                                                                                                                                                                                                                                                                                                            16,000

MANAGEMENT
                                                                                                                                                                                                                                                                                                                                                                                                                                   14,000
                                 10,000

                                                                                                                                                                                                                                                                                                                                                                                                                                   12,000

                                  8,000
                                                                                                                                                                                                                                                                                                                                                                                                                                   10,000
Projected for the next 30 days
                                  6,000                                                                                                                                                                                                                                                                                                                                                                                            8,000

                                                                                                                                                                                                                                                                                                                                                                                                                                   6,000
                                  4,000

                                                                                                                                                                                                                                                                                                                                                                                                                                   4,000

                                  2,000
                                                                                                                                                                                                                                                                                                                                                                                                                                   2,000

                                     0                                                                                                                                                                                                                                                                                                                                                                                             -

                                          2021-02-28
                                                       2021-03-01
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                                                                                                                                                                                                                                                                                                 2021-03-19
                                                                                                                                                                                                                                                                                                              2021-03-20
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                                                                                                                                                                                                                                                                                                                                                                                                                      2021-03-28
                                                                                                                        RBC Supersite                                                    Keystone Supersite                                                            Thompson Supersite                                                                  Total

                                 Projections as of March 2. Each rise in doses represents a scheduled delivery.

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DOSE ADMINISTRATION PROJECTION

• Based on current                                        Daily Doses Administered - Projection
                                                             Does not include doses allocated to First Nations

  supply projections,     4,000                                                                                                       140,000

  we estimate an
                          3,500                                                                                                       120,000

                          3,000
  average of 2,277        2,500
                                                                                                                                      100,000

  injections per day in   2,000
                                                                                                                                      80,000

  March, subject to
                                                                                                                                      60,000
                          1,500

  current vaccine
                                                                                                                                      40,000
                          1,000

  supply forecasts.        500                                                                                                        20,000

                             -                                                                                                        -

                                             Supersites      FIT (Pfizer for WRHA, Moderna for other RHAs)       Total   Cumulative

                                  Projected as of March 2
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LOW-RANGE SCENARIO

Based on Pfizer and Moderna
vaccines.

Allocation details on
AstraZeneca have not been
provided to Manitoba yet.

                              Projected as of March 2
9
HIGH-RANGE SCENARIO

Based on Pfizer, Moderna,
AstraZeneca and other vaccines
that have not yet been approved

                                  Projected as of March 2
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DELIVERING 1.5 MILLION DOSES
SECOND
                                                                                                  Daily
                                • Manitoba continues to report       Site / Approach            Maximum

QUARTER
                                                                                                Capacity
                                  Daily Maximum Capacity
                                                                        Supersites
EXPANSION                       • This shows how many doses
                                                                 (RBC, Backup Site, Keystone,
                                                                     Thompson, Vaxport)
                                                                                                 6,499

Building from Manitoba's          could be delivered on any
small, deliberate and safe        given day in Manitoba if we       Distributed Model            5,000
starting point to deliver the     had adequate supply.
largest immunization                                                  Focused
                                                                                                  500
campaign in provincial                                            Immunization Teams
                                • This will be updated as
history
                                  new facilities and staff are
                                                                      Pop-up Clinics              500
                                  added to increase capacity.
                                                                    Current Daily
                                                                  Maximum Capacity              12,499
                                                                 TARGET CAPACITY Q2             20,000

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CONTINUED   Protecting Manitobans, Building Capacity
PROGRESS
            • First general                       • Morden supersite to open mid-
              population immunizations on           March
              March 1
                                                  • PCH 2nd dose campaign complete
            • Regular expansions of eligibility
              criteria                            • Congregate living facility 1st dose
                                                    campaign underway
            • Vaxport pilot project underway

            • Selkirk supersite opens March 8,
              appointments being booked now

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VACCINE TECHNOLOGY
COVID-19
Vaccines                             Approved vaccines:                        More vaccines expected
                                                                               to be approved Q2+:
Multiple vaccines in various
stages                               • Pfizer-BioNTech
                                       approved Dec. 9, 2020                   •   Johnson & Johnson*
Each approved vaccine,               • Moderna approved Dec.                   •   Novavax
particularly those using different     23, 2020                                •   Sanofi and GSK
technologies, will have different    • AstraZeneca/Covishield                  •   Medicago
indications for use
                                       approved Feb. 26, 2021

                                     *FDA approved Johnson & Johnson one-shot vaccine, Janssen, on Feb. 27, 2021.

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Vaccine Supply   Supply to Canada is Expected to Increase

                 • Supply is expected to increase   • Over 70,000 doses of mRNA
                   exponentially in Q2 as more        vaccine (Pfizer and Moderna)
                   vaccines are approved and          administered in Manitoba to date
                   currently-approved vaccines ramp
                   up production                    • Supply of AstraZeneca expected
                                                      by mid-March

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COVID-19 Vaccine Agreements in Canada

     Supplier / Vaccine             Technology Platform         Doses                       Status
AstraZeneca                              Viral vector          20 million      Approved Feb. 2021
Moderna                                     mRNA               44 million      Approved Dec. 2020
Pifzer-BioNTech                             mRNA            Up to 76 million   Approved Dec. 2020
Johnson & Johnson                        Viral vector       Up to 38 million   Under review; submitted to
                                                                               Health Canada Nov. 11, 2020
Medicago                                 Plant-based        Up to 76 million   Phase III; anticipated to seek
                                                                               licensure Q3, 2021.
Novavax                                Subunit protein      Up to 76 million   Under review; submitted to
                                                                               Health Canada Jan. 29, 2021
Sanofi and GlaxoSmithKline             Subunit protein      Up to 72 million   Phase II; anticipated to seek
                                                                               licensure Q4, 2021.
          Does not include provincially-procured vaccines

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Vaccinology
              • The three vaccines currently       •   The COVID-19 vaccines use RNA
                authorized for use in Canada           or DNA that provide the
                (Pfizer –Biontech mRNA, Moderna        instructions for our immune
                mRNA, and Astra Zeneca DNA)            system to manufacture the protein
                protect us from COVID-19               that causes our immune system to
                infection using a different            produce protective antibodies and
                approach than other, more familiar     immune cells.
                vaccines.

              • For example: The measles
                vaccine fuses a weakened live
                virus that causes our immune
                system to produce protective
                antibodies and immune system
                cells. Flu vaccines use inactivated
                virus to do the same.
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mRNA Vaccines
Pfizer-BioNTech and Moderna   • Storage: ultra-frozen (70˚C) for
                                Pfizer and frozen (-20˚C)
                                for Moderna

                              • Authorized ages: 16+ for Pfizer
                                and 18+ for Moderna

                              • Schedule: 2 doses, 3-4 weeks
                                apart.

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mRNA Vaccine
Effectiveness                 •Both mRNA vaccines were shown to •Emerging ‘real world’ evidence from
                              be safe and effective in preventing lab the UK, Scotland and Israel suggests
Pfizer-BioNTech and Moderna   confirmed COVID-19 infection after that one dose of mRNA vaccine is 70-
                              two doses (with effectiveness around 80% effective in preventing lab
                              94-95%).                                 confirmed COVID-19 infection and
                                                                       also significantly reduced
                              •However, significant protection         hospitalization and death.
                              started about 12-14 days after the first
                              dose and may be above 90% in the •Effectiveness against variants of
                              clinical trials.                         concern is evolving.

20
Viral Vector
(DNA) Vaccines   • Storage: Routine at 2˚C to 8˚C

AstraZeneca      • Authorized age: 18+

                 • Schedule: 2 doses, 4-12 weeks
                   apart (12 weeks preferred)

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Viral Vector
(DNA) Vaccine   •Although the initial clinical trial results •Real world data from the United
                showed the AstraZeneca vaccine to Kingdom in those 70+ are showing
Effectiveness   be moderately effective (around 60%), single dose effectiveness >70% and a
                subsequent analysis of the data              significant reduction in hospitalization
AstraZeneca
                shows that longer intervals between and death.
                dose 1 and dose 2 (12 weeks)
                resulted in effectiveness >80%.              •Data on effectiveness against
                                                             variants of concern is evolving.

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Ongoing
Evaluation                     • Ongoing clinical trials          • Provincial table reviews any
                                                                    reports of AEFI and collaborates
All vaccines continue to be    • Ongoing real-world effectiveness   with national tables
monitored for safety and         studies
effectiveness after they are                                      • Vaccine safety is monitored more
authorized for use             • Federal adverse events following   closely than any other medical
                                  immunization (AEFI) system        intervention

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Which Vaccine
Should I Get?   • If you are eligible to be immunized, • Being immunized with one type of
                  the answer is simple: The first        vaccine now will not prevent you
                  vaccine available to you.              from getting another type
                                                         of COVID-19 vaccine in the future,
                • Locations where you can get            when supplies are greater
                  vaccines will expand, and there will
                  be more types of vaccines            • Get the facts on COVID-19 vaccine
                  available over time.                   from reliable sources

                • But this is key: All vaccines       • Vaccines are safe, effective and
                  approved for use are effective in     are a life-saving intervention
                  preventing you from getting
                  COVID-19, and in reducing the
                  seriousness of your symptoms

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COVID-19 VACCINATION IN MANITOBA
                                             QUESTIONS?
         Media are invited to provide feedback on future tech briefings or
               specific areas of interest to lenore.kowalchuk@gov.mb.ca
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