Graduate Program in "The Molecular Basis of Human Disease" University of Crete Medical School Study in Greece
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Graduate Program in
“The Molecular Basis of Human Disease»
University of Crete Medical School
https://www.grad-mbhd-uoc.gr
Director: D. Kardassis PhD, Professor of Biochemistry
Assoc. Director: P. Sidiropoulos MD/PhD Assoc. Professor of
Rheumatology
April, 2021
Key features of the program
• The program started its operations in 2003 (18th year)
• It offers MSc in “The Molecular Basis of Human Disease”
• Intensive curriculum based on the standards of US graduate
programs (courses- rotations-research)
• All our graduate students are full time in the program
• All lectures and exams are in English
• The graduate students hold BSc degree in Biomedical Sciences or MD
degree
• The graduate students are co-supervised by faculty from the Basic
and the Clinical Departments
Unique features The program combines clinical with basic science in order to investigate the molecular basis and the pathogenesis of human diseases. The program prepares its students to fill up positions in Greek Universities and Research Institutions and to compete for national or international funding The students of the program have the opportunity to select among top research laboratories of Greece and abroad with significant contributions in research The program allows its graduate students to do high quality original research in selected laboratories abroad The program is regularly evaluated by an External Evaluation Committee
The program in numbers Critical mass. Members from the UCrete 30 Extroversion. Members from other 30 Institutions Total number of enrolled students 184 Total number of MSc awarded 160
The program in numbers • Total number of students enrolled: 184 • Student with MD degrees: 49 (27%) • Students with BSc degrees: 135 (73%)
Selection of new graduate students Strict criteria. Applications: 30-40/year. Enrolled: 10-12/year
Program structure
Practical Original
Courses Research
Training
Graduate Lab Months
(Rotations) 13-24
Months 1-8
Months 9-12
MSc diploma
Enrollment in the PhD
program of the University
of Crete Medical School
4-5 years
PhD degree
Curriculum (2020-2021)
Module Title ECTS
1st Semester
MBNA-103 Metabolic and Cardiovascular Diseases 9
MBNA-104 Autoimmune/Autoinflamatory/Infectious Diseases 6
MBNA-108 Biostatistics, Clinical Methodology and Epidemiology 6
MBNA-105 Cancer 4
MBNA-109 Presentations of original papers and writing of a research proposal- Research
ethics and laboratory safety 2
MBNA-106 Neuropsychiatric Diseases 3
Sub-Total 30
2nd Semester
MBNA-107 Regenerative Medicine and Stem Cells 3
MBNA-101 Introduction to the Molecular and Genetic Basis of Human Diseases – Introduction
to Basic research Methodology 5
MBNA-102 Graduate Lab 2
MBNA-110 1st Laboratory Rotation 10
MNBA-111 2nd Laboratory Rotation 10
Sub-total 30
3rd Semester
MBNA -112 Original research 30
4th Semester
Data analysis and writing of the thesis 30
Total 120
Faculty (core and affiliated) Faculty from the University of Crete Medical School (Depts of Basic Sciences, Lab. Medicine, Internal Medicine, Neurology, Mother and Child Health, Morphology and Surgery) Faculty from other Departments of the UoC (Biology, Materials Science) Top scientists from other Greek Institutions Top scientists from foreign Institutions (Europe, US)
Instructors from abroad
Academic Year 2020-2021
• Dr Ed Fisher, New York University Medical School, NY, USA
• Dr Diomedes Logothetis, Northeastern University, Boston, USA
• Dr Michael Czech, University of Massachusetts, Worcester, USA
• Dr Costas Drosatos, Temple University, Philadelphia, USA
• Dr Sylvia Corvera, University of Massachusetts, Worcester, USA1st External evaluation: March 2006 “This is a unique graduate program that seeks to train physician- scientists and academic leaders for Greek medicine in the future. The External Review Committee was extremely impressed with the quality of the Program: the faculty is dedicated to its success; the students are outstanding; and the courses and training that are offered are excellent” https://www.grad-mbhd-uoc.gr/index.php/en/the-program/evaluation
2nd External evaluation: May 2011 “The External Review Committee recognizes the uniqueness of this graduate program, congratulates the Coordinating Committee on its quality, and urges the Ministry of Education of Greece to recognize this as well. If the Program continues to flourish and expand, it will be successful in serving as a source of future outstanding scientists and faculty in medicine and related basic biomedical sciences, and it will continue to further the reputation of the Medical School of the University of Crete as a unique and outstanding research-oriented medical school. The program has the potential to serve as an example for other postgraduate programs in the country, improving the quality of the educational system” https://www.grad-mbhd-uoc.gr/index.php/en/the-program/evaluation
3rd External evaluation: October 2018 “The Program has proved to be a remarkable success story, ably achieving its founding overarching major aims: to train BSc biologists and other basic scientists as well as MD physicians in the basic skills of critical thinking and methods of medical research to become future leaders in biomedical investigation and academic medicine. It is an outstanding program that emphasizes rigorous engagement in multiple disciplines of human diseases, interactions with international leaders in their fields, development of hands-on laboratory skills in contemporary scientific techniques and successful researching a biomedical project that can advance a field. ” https://www.grad-mbhd-uoc.gr/index.php/en/the-program/evaluation
1st graduate program retreat
October 20072nd graduate program retreat
October 2010Selected publications of graduate students (2015-2020) •Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019 Jul 11;178(2):316-329.e18. •LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T. Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids. Cell Metab. 2020 Feb 4;31(2):339-350.e4. •Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR et al.(2017) Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat Med. 23(11):1362-1368. •Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, et al. (2018) Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 172(1-2):147-161. • Andrianaki AM, Kyrmizi I, Thanopoulou K, Baldin C, Drakos E, Soliman SSM, Shetty AC, McCracken C, Akoumianaki T, Stylianou K, Ioannou P, et al. (2018) Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nat Commun. 9(1):3333. •Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, et al. (2017) Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest. 127(10):3624-3639. •Theofilatos D, Fotakis P, Valanti E, Sanoudou D, Zannis V, Kardassis D. (2018) HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway. Metabolism. 2018 Jun 18.[Epub ahead of print] •Tiniakou I, Drakos E, Sinatkas V, Van Eck M, Zannis VI, Boumpas D, Verginis P, Kardassis D. (2015) High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function. J Immunol. 194(10):4676-87. •Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Poliska S, Cuvellier S, Ben Larbi S, Sansbury BE, Spite M, Brown CW, Chazaud B, Nagy L. Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. (2016) Immunity. 45(5):1038-1051.
Alumni careers
Magda Nakou Pfizer Hellas
Aggelos Oikonomopoulos Bristol-Meyers Squibb, CA, USA
Panagiotis Fotakis Dren Bio Inc. San Francisco, USA
Ioanna Timiakou Post-doctoral fellow, NYU Medical School
Giorgos Bertsias Assoc. Prof. in Rheumatology,/Clinical Immunology, Un. of Crete
Medical School
Eleni Vergadi Assist. Prof. in Pediatrics, Un. Of Crete Medical School
Ioanna Mosialou Assistant Professor, Columbia Univ.
Andreas Patsalos Postdoctoral Research Fellow at The Johns Hopkins
University School of Medicine, USA
Andreas Kateifidis Sr. Business Operations Analyst, Process Management &
Business Analytics at Vertex PharmaceuticalsNewsletter: 10 issues- New issue in May 2021
New web page: www.grad-mbhd-uoc.gr (access from PC, mobiles phones, tablets)
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