MICROGRAVITY LAUNCH YOUR LIFE SCIENCE RESEARCH TO THE NEXT LEVEL: yuri GmbH
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LAUNCH YOUR LIFE SCIENCE
RESEARCH TO THE NEXT LEVEL:
MICROGRAVITY
yuri GmbH | 2021
Image Credit: NASA
WHO WE ARE
YURI is a space company from
Germany. We enable life science
research in microgravity.
We are space nerds with 30+ years of
experience and have launched 11 ISS
payloads to date. Our customers are
space agencies like NASA, research
institutes like UCLA, UTS and UZH and
pharma giants like GlaxoSmithKline.
yuri GmbH | 2021
BENEFITS FOR THE
LIFE SCIENCES
The absence of gravity has great effects on biological
systems that can improve the outcome of your research
Protein Crystals grow larger Cells grow in all dimensions Stem cells show greater proliferation and Cells show
and with fewer defects and similarly to human tissue stemness while differentiating slower accelerated aging
Drug Discovery Drug Efficacy Testing Regenerative Cancer, Osteoporosis
Drug Delivery Tissue Engineering Medicine Therapies
Details Details Details Details
on page 8 on page 9 on page 9 on page 9
yuri GmbH | 2021
YURI | YOUR LAB IN MICROGRAVITY
Whatever your requirements are, we help you to perform research in
microgravity quickly and affordably. No space experience needed.
How it works
Define Select Test & Train Execute Analyze
Experiment Hardware On Ground Mission Samples
With our online Choose from a variety of You receive extensive We organize all launch After your experiment
configuration tool you can flight-proven experiment training on the hardware logistics, such as export returns from space, we will
define parameters such as hardware for cells, crystals, and can perform enough control, safety, and launch ship it back to you for your
microgravity duration, plants, fruit flies or fish. dry runs in your lab before bookings for you. For ISS analysis. You can also
temperature, live data or Customized hardware is your experiment goes into missions, we will watch the receive certain live data
fluid exchange. also possible. space. launch together in Florida. while in space.
yuri GmbH | 2021
Image Credit: SpaceX
FLIGHT-PROVEN, REUSABLE
SPACE BIOREACTORS
Choose from our growing portfolio of off-the-shelf experiment hardware for a variety of research areas.
fishes plants crystals
cells flies
custom
yuri GmbH | 2021
NOT READY FOR SPACE YET?
START WITH A CLINOSTAT
A Clinostat rotates samples constantly
perpendicularly to the gravitational field to hinder the 1g Reference Rack
biological system from adapting to gravitation.
Our self-developed Clinostat provides space for up
to 45 sample vessels (e.g. Falcon, Eppis) and can Expansion Module
easily be controlled with a modern touch screen.
ü Microgravity, Moon, and Mars gravity possible
ü Wide range of compatible sample sizes (1-15 ml)
Base Module
ü Can be used inside incubators
ü Control unit outside incubator for permanent
surveillance and control
ü Automated calculation of optimal rotational
velocity Control Unit with
Touch Interface
yuri GmbH | 2021
Image Credit:
ISS National Lab
Research
Protein Crystal Growth
Areas Cell Cultures/Tissues
yuri GmbH | 2021
Image Credit:
PROTEIN CRYSTAL GROWTH
ISS National Lab
Examples: Merck
>15 Experiments were conducted by Merck on the
Space Shuttle and through ISS missions to date.
With Gravity Without Gravity
50% larger crystals were grown in microgravity
compared to ground controls.
Crystal growth in microgravity The experiments also yielded a more uniform
crystalline suspension (20-micron crystals) with
ü reduced sedimentation better dissolution properties. A one-liter bottle
ü minimized convection currents of a drug from one experiment generated
ü reduced molecular diffusion rates enough crystals to use in primate studies for
ü crystals are larger, higher order, purer two years, greatly driving the research forward.
ü more uniform crystalline suspensions
is a large molecule biologic which is painful to
deliver and needs a hospital setting. Merck
Areas of interest for Pharma/Biotech crystallized KEYTRUDA® in space and found a
KEYTRUDA® new shape (polymorph) that could allow for
KEYTRUDA® to be given either by a shot or
Drug Discovery Drug Delivery something like an insulin pump – thus deliver it
structure-based enabling subcutaneous
less painfully into the body.
drug design and pulmonary delivery
Other companies:
Product Development Manufacturing Eli Lilly, GlaxoSmithKline, Bristol Myers Squibb,
controlled release, high- efficient purification, stable Michael J. Fox Foundation
concentration formulations concentrations for storage
yuri GmbH | 2021
Source: Merck, ISS National Lab
Image Credit:
CELL CULTURES/TISSUES
University of Magdeburg
Examples: Sanofi Pasteur, University of Magdeburg
Sanofi Pasteur grew MDCK cell cultures infected
With Gravity Without Gravity with influenza virus in microgravity to explore
mechanisms in viral replication. Cell-based
methods allow better response to pandemic
Cell cultures in microgravity outbreaks, greater process control, and a more
ü cells form 3D structures without VIRUSES reliable product than egg-production methods.
However, cell-culture based methods are costly.
scaffolding, mimic in vivo conditions The hypothesis: microgravity enhances influenza
ü cell-cell interactions are more like in the replication, leading to insights on how to improve
human body viral yield in cell cultures - the biggest cost driver in
ü stem cells show greater proliferation and vaccine manufacturing.
stemness and differentiate slower
The University of Magdeburg studied the influence
ü changes in gene expression of microgravity on human thyroid cancer cells.
ü cells do not sediment Without gravity they grew into large spherical
ü transfer of nutrients/waste is driven by TUMOR clusters of thousands of tumor cells – 3D tumor
diffusion spheroids - which resemble the original tumor. This
SPHEROIDS knowledge could be used to cultivate tumor
spheroids. If these could be produced artificially on
Areas of interest for Pharma/Biotech Earth, pharma companies could test anti-tumor
drugs against many cancer types without animal
Drug Development Tissue Engineering experiments - a revolution in cancer research.
disease modeling, organoid growth, bioprinting
toxicity testing without scaffolds
yuri GmbH | 2021
Source: ISS National Lab, DLR
3 WAYS TO GET STARTED
Sounds interesting, but I My budget is limited, I have an idea and like to start
don’t have a concrete idea I want to do lab research first with a low-cost ISS experiment
BOOK A WORKSHOP RENT A CLINOSTAT LAUNCH A SCIENCEBOX
Find the right experiment Start with simulations in your The real thing: send 3 experiment
idea with our efficient lab before going into space. units (e.g. 3 x 1 cell cultures) in a
design thinking process. Rent or buy our Clinostat. box to the ISS for 30 days.
2,990 € 930 €/month 95,000 €
1 day ideation workshop basic package for 15 sample vessels 10cm cube to ISS incl. return
yuri GmbH | 2021democratizing microgravity Web www.yurigravity.com Email mark.kugel@yurigravity.com Phone +49 7542 508 4954 Office yuri GmbH | Wiesentalstr. 40 | Meckenbeuren | Germany
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